Hub : Traits

Short access day 10 total inactive lever presses

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

3 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 8 65409201 66802272 1 1 3.5e-07 0.0134 0.0295 23 Plekho2
2 8 108584253 109479622 1 1 2.7e-11 0.0016 0.0047 19 Apeh
3 9 24497174 25018277 1 1 1.2e-08 0.0057 1.0000 100 Rims1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Liver weight, left 4.0 1 0 0 0 1 Apeh
Extensor digitorum longus weight 1.5 1 0 0 0 1 Plekho2
Std. dev. time between licks in bursts 6.9 1 0 0 0 1 Apeh
Indifference point 0 sec 3.8 1 0 0 0 1 Apeh
Delay discounting total patch changes 18 sec 5.9 1 0 0 0 1 Apeh
Delay discounting total patch changes 6 sec 4.9 1 0 0 0 1 Apeh
Light reinforcement 2 7.7 1 0 0 0 1 Rims1
Saline control response 4.4 1 0 0 0 1 Apeh
Conditioned reinforcement - inactives 18.9 2 1 33 0 1 Rims1 Apeh
Conditioned locomotion 5.3 1 0 0 0 1 Apeh
Intermittent access intake day 1-15 change 26.8 1 1 33 0 1 Apeh
Intermittent access intake escalation 21.2 1 0 0 0 1 Apeh
Intermittent access intake escalation 2 29.8 1 1 33 0 1 Apeh
Intermitt. access day 1 inactive lever presses 15.1 1 0 0 0 1 Rims1
Intermitt. access day 15 inactive lever presses 17.5 2 1 33 0 1 Rims1 Apeh
Intermittent access standard deviation 34.3 1 1 33 0 1 Apeh
Cocaine induced anxiety 6.4 1 0 0 0 1 Apeh
Incentive Sensitization - Responses 8.6 2 0 0 0 1 Rims1 Apeh
Incentive Sensitization - Breakpoint 7.5 2 0 0 0 1 Rims1 Apeh
Progressive ratio test 1 active lever presses 10.8 2 0 0 0 1 Rims1 Apeh
Progressive ratio test 1 breakpoint 12.2 2 0 0 0 1 Rims1 Apeh
Progressive ratio test 1 inactive lever presses 8.5 1 0 0 0 1 Apeh
Progressive ratio test 2 active lever presses 14.2 1 0 0 0 1 Rims1
Progressive ratio test 2 breakpoint 16.4 1 0 0 0 1 Rims1
Progressive ratio test 2 inactive lever presses 41.5 1 1 33 0 1 Apeh
Total sessions with >9 infusions 12.6 1 0 0 0 1 Apeh
Short access day 1 total inactive lever presses 7.7 1 0 0 0 1 Apeh
Short access total infusions 5.5 1 0 0 0 1 Rims1
Short access day 10 total locomotion 6.4 1 0 0 0 1 Apeh
Short access total locomotion 10.7 1 0 0 0 1 Apeh
Compulsive drug intake 7.7 1 0 0 0 1 Apeh
Number of responses in last shaping day 12.0 1 0 0 0 1 Apeh
Locomotion distance, session 1 4.5 1 0 0 0 1 Plekho2
Locomotion velocity, session 3 6.6 1 0 0 0 1 Rims1
Novel to familiar place preference ratio 6.2 1 0 0 0 1 Apeh
Novelty place preference 7.0 1 0 0 0 1 Apeh
Time in novel zone, NPP test 6.8 1 0 0 0 1 Apeh
Pavlov. Cond. magazine entry latency 5.4 1 0 0 0 1 Apeh
Pavlov. Cond. lever-magazine prob. diff. 4.9 1 0 0 0 1 Apeh
Pavlov. Cond. response bias 5.3 1 0 0 0 1 Apeh
Distance traveled before self-admin 5.8 1 0 0 0 1 Rims1
Extinction: sum of active levers before priming 27.4 1 1 33 0 1 Rims1
Delta distance traveled before/after self-admin 12.2 1 0 0 0 1 Rims1
Delta ambulatory time before/after self-admin 5.3 1 0 0 0 1 Rims1
Time in closed arm after self-admin 7.5 1 0 0 0 1 Rims1
Time to tail flick, vehicle, before self-admin 9.4 1 0 0 0 1 Rims1
Ambulatory time before self-admin 10.3 1 0 0 0 1 Apeh
Time >=10cm from walls, locomotor time 1 29.0 1 1 33 0 1 Rims1
Bouts of movement, locomotor time 1 6.0 1 0 0 0 1 Rims1
Total resting periods, locomotor time 1 7.0 1 0 0 0 1 Rims1
Vertical activity count, locomotor time 1 6.1 1 0 0 0 1 Rims1
Bouts of movement, locomotor time 2 26.4 1 1 33 0 1 Rims1
Total resting periods, locomotor time 2 30.9 1 1 33 0 1 Rims1
Locomotion in novel chamber post-restriction 5.2 1 0 0 0 1 Rims1
Cu content in liver 4.8 1 0 0 0 1 Apeh

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.1
Adipose alternative TSS 0 0.000 1.1
Adipose gene expression 0 0.000 1.1
Adipose isoform ratio 0 0.000 1.1
Adipose intron excision ratio 0 0.000 1.1
Adipose mRNA stability 0 0.000 1.1
BLA alternative polyA 0 0.000 1.1
BLA alternative TSS 0 0.000 1.1
BLA gene expression 0 0.000 1.1
BLA isoform ratio 0 0.000 1.1
BLA intron excision ratio 0 0.000 1.1
BLA mRNA stability 0 0.000 1.2
Brain alternative polyA 0 0.000 1.1
Brain alternative TSS 0 0.000 1.2
Brain gene expression 0 0.000 1.1
Brain isoform ratio 0 0.000 1.1
Brain intron excision ratio 0 0.000 1.1
Brain mRNA stability 1 0.023 1.1
Eye alternative polyA 0 0.000 1.2
Eye alternative TSS 0 0.000 1.2
Eye gene expression 0 0.000 1.1
Eye isoform ratio 0 0.000 1.1
Eye intron excision ratio 0 0.000 1.0
Eye mRNA stability 0 0.000 1.0
IL alternative polyA 0 0.000 1.1
IL alternative TSS 0 0.000 1.0
IL gene expression 0 0.000 1.1
IL isoform ratio 0 0.000 1.2
IL intron excision ratio 0 0.000 1.1
IL mRNA stability 0 0.000 1.2
LHb alternative polyA 0 0.000 1.2
LHb alternative TSS 0 0.000 1.1
LHb gene expression 0 0.000 1.1
LHb isoform ratio 0 0.000 1.2
LHb intron excision ratio 0 0.000 1.2
LHb mRNA stability 0 0.000 1.1
Liver alternative polyA 0 0.000 1.1
Liver alternative TSS 0 0.000 1.0
Liver gene expression 0 0.000 1.1
Liver isoform ratio 0 0.000 1.0
Liver intron excision ratio 0 0.000 1.1
Liver mRNA stability 0 0.000 1.1
NAcc alternative polyA 0 0.000 1.1
NAcc alternative TSS 0 0.000 1.1
NAcc gene expression 1 0.016 1.1
NAcc isoform ratio 0 0.000 1.1
NAcc intron excision ratio 0 0.000 1.1
NAcc mRNA stability 0 0.000 1.2
OFC alternative polyA 0 0.000 1.2
OFC alternative TSS 0 0.000 1.0
OFC gene expression 0 0.000 1.1
OFC isoform ratio 0 0.000 1.1
OFC intron excision ratio 0 0.000 1.1
OFC mRNA stability 0 0.000 1.1
PL alternative polyA 0 0.000 1.2
PL alternative TSS 0 0.000 1.1
PL gene expression 0 0.000 1.1
PL isoform ratio 0 0.000 1.2
PL intron excision ratio 0 0.000 1.1
PL mRNA stability 1 0.034 1.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.