Hub : Traits

Progressive ratio test 1 inactive lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	15	24291347	25661910	1	1	2.78e-07	8.66e-02	5.76e-01	Rab2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1.69	1	0	0	0	1e+00	Rab2b
BMI without tail	2.21	1	0	0	0	1e+00	Rab2b
Body weight	1.44	1	0	0	0	1e+00	Rab2b
Parametrial fat weight	2.62	1	0	0	0	1e+00	Rab2b
Extensor digitorum longus weight	2.25	1	0	0	0	1e+00	Rab2b
Tibialis anterior weight	1.91	1	0	0	0	1e+00	Rab2b
Food consumed during 24 hour testing period	6.03	1	0	0	0	1e+00	Rab2b
Mean time between licks in bursts	5.05	1	0	0	0	1e+00	Rab2b
Mean num. licks in bursts	3.74	1	0	0	0	1e+00	Rab2b
Std. dev. time between licks in bursts	3.45	1	0	0	0	1e+00	Rab2b
Water consumed over 24 hours	3.31	1	0	0	0	1e+00	Rab2b
Delay discounting total patch changes 0 sec	2.48	1	0	0	0	1e+00	Rab2b
Delay discounting total patch changes 18 sec	3.36	1	0	0	0	1e+00	Rab2b
Delay discounting total patch changes 24 sec	5.58	1	0	0	0	1e+00	Rab2b
Delay discounting total patch changes 6 sec	3.33	1	0	0	0	1e+00	Rab2b
Locomotor testing rearing	2.49	1	0	0	0	1e+00	Rab2b
Light reinforcement 1	3.71	1	0	0	0	1e+00	Rab2b
Reaction time false alarm rate	2.84	1	0	0	0	1e+00	Rab2b
Pavlov. Cond. intertrial magazine entries	4.73	1	0	0	0	1e+00	Rab2b
Intermittent access intake escalation	5.62	1	0	0	0	1e+00	Rab2b
Intermittent access intake escalation 2	4.07	1	0	0	0	1e+00	Rab2b
Intermitt. access day 15 inactive lever presses	4.92	1	0	0	0	1e+00	Rab2b
Intermittent access day 15 total infusions	8.55	1	0	0	0	1e+00	Rab2b
Intermittent access total infusions	9.59	1	0	0	0	1e+00	Rab2b
Intermittent access day 15 total locomotion	4.78	1	0	0	0	1e+00	Rab2b
Intermittent access total locomotion	5.53	1	0	0	0	1e+00	Rab2b
Intermittent access standard deviation	14.39	1	0	0	0	1e+00	Rab2b
Cocaine induced anxiety	27.51	1	1	100	0	1e+00	Rab2b
Post-drug Anxiety	20.3	1	0	0	0	1e+00	Rab2b
Baseline Anxiety	7.69	1	0	0	0	1e+00	Rab2b
Lifetime Intake	15.56	1	0	0	0	1e+00	Rab2b
Progressive ratio test 1 active lever presses	3.74	1	0	0	0	1e+00	Rab2b
Progressive ratio test 2 active lever presses	6.76	1	0	0	0	1e+00	Rab2b
Progressive ratio test 2 breakpoint	6.31	1	0	0	0	1e+00	Rab2b
Progressive ratio test 2 inactive lever presses	6.63	1	0	0	0	1e+00	Rab2b
Short access day 10 total inactive lever presses	12.81	1	0	0	0	1e+00	Rab2b
Short access day 1 total infusions	12.77	1	0	0	0	1e+00	Rab2b
Short access total infusions	10.9	1	0	0	0	1e+00	Rab2b
Short access day 1 locomotion	5.28	1	0	0	0	1e+00	Rab2b
Short access day 10 total locomotion	4.12	1	0	0	0	1e+00	Rab2b
Short access total locomotion	7.42	1	0	0	0	1e+00	Rab2b
One hour access (0.3 mA shock)	8.71	1	0	0	0	1e+00	Rab2b
One hour access (shock baseline)	17.75	1	0	0	0	1e+00	Rab2b
Number of responses in last shaping day	12.59	1	0	0	0	1e+00	Rab2b
Degree of sensitization distance	4.39	1	0	0	0	1e+00	Rab2b
Distance traveled before self-admin	11.31	1	0	0	0	1e+00	Rab2b
Distance traveled after self-admin	6.65	1	0	0	0	1e+00	Rab2b
Delta time in closed arm before/after self-admin	4.91	1	0	0	0	1e+00	Rab2b
Time in closed arm after self-admin	8.7	1	0	0	0	1e+00	Rab2b
Time to tail flick, test, after self-admin	9.75	1	0	0	0	1e+00	Rab2b
Ambulatory time before self-admin	14.19	1	0	0	0	1e+00	Rab2b
Ambulatory time after self-admin	5.37	1	0	0	0	1e+00	Rab2b
Delay disc. indifference point, 24s delay	11.91	1	0	0	0	1e+00	Rab2b
Time >=10cm from walls, locomotor time 1	14.73	1	0	0	0	1e+00	Rab2b
Bouts of movement, locomotor time 1	5.61	1	0	0	0	1e+00	Rab2b
Total resting periods, locomotor time 1	4.95	1	0	0	0	1e+00	Rab2b
Time >=10cm from walls, locomotor time 2	4.51	1	0	0	0	1e+00	Rab2b
Bouts of movement, locomotor time 2	7.37	1	0	0	0	1e+00	Rab2b
Total resting periods, locomotor time 2	6.36	1	0	0	0	1e+00	Rab2b
Latency to leave start box in cocaine runway	11.21	1	0	0	0	1e+00	Rab2b
Latency to leave start box in cocaine runway, M	6.37	1	0	0	0	1e+00	Rab2b
Cu content in liver	3.35	1	0	0	0	1e+00	Rab2b
K content in liver	5.36	1	0	0	0	1e+00	Rab2b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	1	0	0.96
Adipose	alternative TSS	0	0	1.11
Adipose	gene expression	0	0	1.11
Adipose	isoform ratio	0	0	1.04
Adipose	intron excision ratio	0	0	1.06
Adipose	mRNA stability	0	0	1.09
BLA	alternative polyA	0	0	0.9
BLA	alternative TSS	0	0	1.03
BLA	gene expression	0	0	1.07
BLA	isoform ratio	0	0	1.07
BLA	intron excision ratio	0	0	1.04
BLA	mRNA stability	0	0	1.15
Brain	alternative polyA	0	0	0.97
Brain	alternative TSS	0	0	1.14
Brain	gene expression	0	0	1.08
Brain	isoform ratio	0	0	1.11
Brain	intron excision ratio	0	0	1.07
Brain	mRNA stability	0	0	1.14
Eye	alternative polyA	0	0	1.14
Eye	alternative TSS	0	0	1.04
Eye	gene expression	0	0	1.08
Eye	isoform ratio	0	0	1.19
Eye	intron excision ratio	0	0	1.03
Eye	mRNA stability	0	0	1.09
IL	alternative polyA	0	0	0.9
IL	alternative TSS	0	0	0.94
IL	gene expression	0	0	1.08
IL	isoform ratio	0	0	1.08
IL	intron excision ratio	0	0	1.1
IL	mRNA stability	0	0	1.2
LHb	alternative polyA	0	0	0.89
LHb	alternative TSS	0	0	0.97
LHb	gene expression	0	0	1.06
LHb	isoform ratio	0	0	0.97
LHb	intron excision ratio	0	0	1.03
LHb	mRNA stability	0	0	1.17
Liver	alternative polyA	0	0	0.94
Liver	alternative TSS	0	0	1.06
Liver	gene expression	0	0	1.07
Liver	isoform ratio	0	0	1.14
Liver	intron excision ratio	0	0	1.07
Liver	mRNA stability	0	0	1.09
NAcc	alternative polyA	0	0	0.94
NAcc	alternative TSS	0	0	1.04
NAcc	gene expression	0	0	1.09
NAcc	isoform ratio	0	0	1.06
NAcc	intron excision ratio	0	0	1.09
NAcc	mRNA stability	0	0	1.12
OFC	alternative polyA	0	0	0.89
OFC	alternative TSS	0	0	0.97
OFC	gene expression	0	0	1.08
OFC	isoform ratio	0	0	1.12
OFC	intron excision ratio	0	0	1.04
OFC	mRNA stability	0	0	1.12
PL	alternative polyA	0	0	0.97
PL	alternative TSS	0	0	1.13
PL	gene expression	0	0	1.08
PL	isoform ratio	0	0	1.1
PL	intron excision ratio	0	0	1.08
PL	mRNA stability	0	0	1.13