Hub : Traits

Progressive ratio test 1 inactive lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 24291347 25661910 1 1 2.8e-07 0.087 0.58 89 Rab2b

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 1.7 1 0 0 0 1 Rab2b
BMI without tail 2.2 1 0 0 0 1 Rab2b
Body weight 1.4 1 0 0 0 1 Rab2b
Parametrial fat weight 2.6 1 0 0 0 1 Rab2b
Extensor digitorum longus weight 2.2 1 0 0 0 1 Rab2b
Tibialis anterior weight 1.9 1 0 0 0 1 Rab2b
Food consumed during 24 hour testing period 6.0 1 0 0 0 1 Rab2b
Mean time between licks in bursts 5.0 1 0 0 0 1 Rab2b
Mean num. licks in bursts 3.7 1 0 0 0 1 Rab2b
Std. dev. time between licks in bursts 3.5 1 0 0 0 1 Rab2b
Water consumed over 24 hours 3.3 1 0 0 0 1 Rab2b
Delay discounting total patch changes 0 sec 2.5 1 0 0 0 1 Rab2b
Delay discounting total patch changes 18 sec 3.4 1 0 0 0 1 Rab2b
Delay discounting total patch changes 24 sec 5.6 1 0 0 0 1 Rab2b
Delay discounting total patch changes 6 sec 3.3 1 0 0 0 1 Rab2b
Locomotor testing rearing 2.5 1 0 0 0 1 Rab2b
Light reinforcement 1 3.7 1 0 0 0 1 Rab2b
Reaction time false alarm rate 2.8 1 0 0 0 1 Rab2b
Pavlov. Cond. intertrial magazine entries 4.7 1 0 0 0 1 Rab2b
Intermittent access intake escalation 5.6 1 0 0 0 1 Rab2b
Intermittent access intake escalation 2 4.1 1 0 0 0 1 Rab2b
Intermitt. access day 15 inactive lever presses 4.9 1 0 0 0 1 Rab2b
Intermittent access day 15 total infusions 8.6 1 0 0 0 1 Rab2b
Intermittent access total infusions 9.6 1 0 0 0 1 Rab2b
Intermittent access day 15 total locomotion 4.8 1 0 0 0 1 Rab2b
Intermittent access total locomotion 5.5 1 0 0 0 1 Rab2b
Intermittent access standard deviation 14.4 1 0 0 0 1 Rab2b
Cocaine induced anxiety 27.5 1 1 100 0 1 Rab2b
Post-drug Anxiety 20.3 1 0 0 0 1 Rab2b
Baseline Anxiety 7.7 1 0 0 0 1 Rab2b
Lifetime Intake 15.6 1 0 0 0 1 Rab2b
Progressive ratio test 1 active lever presses 3.7 1 0 0 0 1 Rab2b
Progressive ratio test 2 active lever presses 6.8 1 0 0 0 1 Rab2b
Progressive ratio test 2 breakpoint 6.3 1 0 0 0 1 Rab2b
Progressive ratio test 2 inactive lever presses 6.6 1 0 0 0 1 Rab2b
Short access day 10 total inactive lever presses 12.8 1 0 0 0 1 Rab2b
Short access day 1 total infusions 12.8 1 0 0 0 1 Rab2b
Short access total infusions 10.9 1 0 0 0 1 Rab2b
Short access day 1 locomotion 5.3 1 0 0 0 1 Rab2b
Short access day 10 total locomotion 4.1 1 0 0 0 1 Rab2b
Short access total locomotion 7.4 1 0 0 0 1 Rab2b
One hour access (0.3 mA shock) 8.7 1 0 0 0 1 Rab2b
One hour access (shock baseline) 17.8 1 0 0 0 1 Rab2b
Number of responses in last shaping day 12.6 1 0 0 0 1 Rab2b
Degree of sensitization distance 4.4 1 0 0 0 1 Rab2b
Distance traveled before self-admin 11.3 1 0 0 0 1 Rab2b
Distance traveled after self-admin 6.7 1 0 0 0 1 Rab2b
Delta time in closed arm before/after self-admin 4.9 1 0 0 0 1 Rab2b
Time in closed arm after self-admin 8.7 1 0 0 0 1 Rab2b
Time to tail flick, test, after self-admin 9.8 1 0 0 0 1 Rab2b
Ambulatory time before self-admin 14.2 1 0 0 0 1 Rab2b
Ambulatory time after self-admin 5.4 1 0 0 0 1 Rab2b
Delay disc. indifference point, 24s delay 11.9 1 0 0 0 1 Rab2b
Time >=10cm from walls, locomotor time 1 14.7 1 0 0 0 1 Rab2b
Bouts of movement, locomotor time 1 5.6 1 0 0 0 1 Rab2b
Total resting periods, locomotor time 1 5.0 1 0 0 0 1 Rab2b
Time >=10cm from walls, locomotor time 2 4.5 1 0 0 0 1 Rab2b
Bouts of movement, locomotor time 2 7.4 1 0 0 0 1 Rab2b
Total resting periods, locomotor time 2 6.4 1 0 0 0 1 Rab2b
Latency to leave start box in cocaine runway 11.2 1 0 0 0 1 Rab2b
Latency to leave start box in cocaine runway, M 6.4 1 0 0 0 1 Rab2b
Cu content in liver 3.4 1 0 0 0 1 Rab2b
K content in liver 5.4 1 0 0 0 1 Rab2b

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 1 0.047 0.96
Adipose alternative TSS 0 0.000 1.11
Adipose gene expression 0 0.000 1.11
Adipose isoform ratio 0 0.000 1.04
Adipose intron excision ratio 0 0.000 1.06
Adipose mRNA stability 0 0.000 1.09
BLA alternative polyA 0 0.000 0.90
BLA alternative TSS 0 0.000 1.03
BLA gene expression 0 0.000 1.07
BLA isoform ratio 0 0.000 1.07
BLA intron excision ratio 0 0.000 1.04
BLA mRNA stability 0 0.000 1.15
Brain alternative polyA 0 0.000 0.97
Brain alternative TSS 0 0.000 1.14
Brain gene expression 0 0.000 1.08
Brain isoform ratio 0 0.000 1.11
Brain intron excision ratio 0 0.000 1.07
Brain mRNA stability 0 0.000 1.14
Eye alternative polyA 0 0.000 1.14
Eye alternative TSS 0 0.000 1.04
Eye gene expression 0 0.000 1.08
Eye isoform ratio 0 0.000 1.19
Eye intron excision ratio 0 0.000 1.03
Eye mRNA stability 0 0.000 1.09
IL alternative polyA 0 0.000 0.90
IL alternative TSS 0 0.000 0.94
IL gene expression 0 0.000 1.08
IL isoform ratio 0 0.000 1.08
IL intron excision ratio 0 0.000 1.10
IL mRNA stability 0 0.000 1.20
LHb alternative polyA 0 0.000 0.89
LHb alternative TSS 0 0.000 0.97
LHb gene expression 0 0.000 1.06
LHb isoform ratio 0 0.000 0.97
LHb intron excision ratio 0 0.000 1.03
LHb mRNA stability 0 0.000 1.17
Liver alternative polyA 0 0.000 0.94
Liver alternative TSS 0 0.000 1.06
Liver gene expression 0 0.000 1.07
Liver isoform ratio 0 0.000 1.14
Liver intron excision ratio 0 0.000 1.07
Liver mRNA stability 0 0.000 1.09
NAcc alternative polyA 0 0.000 0.94
NAcc alternative TSS 0 0.000 1.04
NAcc gene expression 0 0.000 1.09
NAcc isoform ratio 0 0.000 1.06
NAcc intron excision ratio 0 0.000 1.09
NAcc mRNA stability 0 0.000 1.12
OFC alternative polyA 0 0.000 0.89
OFC alternative TSS 0 0.000 0.97
OFC gene expression 0 0.000 1.08
OFC isoform ratio 0 0.000 1.12
OFC intron excision ratio 0 0.000 1.04
OFC mRNA stability 0 0.000 1.12
PL alternative polyA 0 0.000 0.97
PL alternative TSS 0 0.000 1.13
PL gene expression 0 0.000 1.08
PL isoform ratio 0 0.000 1.10
PL intron excision ratio 0 0.000 1.08
PL mRNA stability 0 0.000 1.13

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.