Progressive ratio test 1 inactive lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr7 14449451 15768722 1 1 9.9e-09 3.85e-01 1e+00 LOC102551633

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
Patch foraging indifference point 0 sec 7.74 1 0 0 0 1e+00 LOC102551633
Patch foraging total patch changes 0 sec 7.23 1 0 0 0 1e+00 LOC102551633
Patch foraging total patch changes 12 sec 3.45 1 0 0 0 1e+00 LOC102551633
Patch foraging total patch changes 6 sec 5.65 1 0 0 0 1e+00 LOC102551633
Locomotor activity 4.19 1 0 0 0 1e+00 LOC102551633
Locomotor testing distance 3.92 1 0 0 0 1e+00 LOC102551633
Locomotor testing rearing 2.61 1 0 0 0 1e+00 LOC102551633
Conditioned reinforcement - actives 6.27 1 0 0 0 1e+00 LOC102551633
Conditioned reinforcement - inactives 5.74 1 0 0 0 1e+00 LOC102551633
Conditioned locomotion 53.64 1 1 100 0 1e+00 LOC102551633
Intermittent access intake day 1-15 change 4.5 1 0 0 0 1e+00 LOC102551633
Intermittent access intake escalation 3.96 1 0 0 0 1e+00 LOC102551633
Intermittent access intake escalation 2 13.41 1 0 0 0 1e+00 LOC102551633
Intermitt. access day 1 inactive lever presses 4.45 1 0 0 0 1e+00 LOC102551633
Intermitt. access escalation Index 57.91 1 1 100 0 1e+00 LOC102551633
Intermittent access day 1 total infusions 19.51 1 0 0 0 1e+00 LOC102551633
Intermittent access day 15 total infusions 6.27 1 0 0 0 1e+00 LOC102551633
Intermittent access terminal intake (last 3 days) 58.42 1 1 100 0 1e+00 LOC102551633
Intermittent access total infusions 12.85 1 0 0 0 1e+00 LOC102551633
Intermittent access day 15 total locomotion 32.88 1 1 100 0 1e+00 LOC102551633
Intermittent access total locomotion 12.95 1 0 0 0 1e+00 LOC102551633
Lifetime Intake 15.71 1 0 0 0 1e+00 LOC102551633
Incentive Sensitization - Responses 8.44 1 0 0 0 1e+00 LOC102551633
Incentive Sensitization - Breakpoint 6.89 1 0 0 0 1e+00 LOC102551633
Progressive ratio test 1 active lever presses 16.85 1 0 0 0 1e+00 LOC102551633
Progressive ratio test 1 breakpoint 36.73 1 1 100 0 1e+00 LOC102551633
Progressive ratio test 2 inactive lever presses 22.31 1 0 0 0 1e+00 LOC102551633
Total sessions with >9 infusions 3.8 1 0 0 0 1e+00 LOC102551633
Short access day 1 total inactive lever presses 7.07 1 0 0 0 1e+00 LOC102551633
Short access day 10 total inactive lever presses 17.14 1 0 0 0 1e+00 LOC102551633
Short access day 1 total infusions 71.59 1 1 100 0 1e+00 LOC102551633
Short access day 10 total infusions 30.94 1 1 100 0 1e+00 LOC102551633
Short access total infusions 43.84 1 1 100 0 1e+00 LOC102551633
Short access day 1 locomotion 22.2 1 0 0 0 1e+00 LOC102551633
Short access day 10 total locomotion 4.41 1 0 0 0 1e+00 LOC102551633
Compulsive drug intake 4.56 1 0 0 0 1e+00 LOC102551633
One hour access (shock baseline) 6.09 1 0 0 0 1e+00 LOC102551633
Number of responses in last shaping day 16.84 1 0 0 0 1e+00 LOC102551633
Locomotion distance, session 3 4.8 1 0 0 0 1e+00 LOC102551633
Degree of sensitization distance 11.08 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. lever latency 5.45 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. index score 3.29 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. latency score 4.54 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. lever contacts 5.74 1 0 0 0 1e+00 LOC102551633
Bone: final force 3.95 1 0 0 0 1e+00 LOC102551633
Bone: final moment 3.68 1 0 0 0 1e+00 LOC102551633
Bone: maximum force 3.84 1 0 0 0 1e+00 LOC102551633
Bone: maximum moment 3.51 1 0 0 0 1e+00 LOC102551633
Bone: minimum diameter 2.49 1 0 0 0 1e+00 LOC102551633
Bone: stiffness 4.72 1 0 0 0 1e+00 LOC102551633
Distance traveled before self-admin 53.87 1 1 100 0 1e+00 LOC102551633
Distance traveled after self-admin 46.63 1 1 100 0 1e+00 LOC102551633
Extinction: sum of active levers before priming 26.18 1 0 0 0 1e+00 LOC102551633
Delta ambulatory time before/after self-admin 13.21 1 0 0 0 1e+00 LOC102551633
Time in closed arm after self-admin 7.65 1 0 0 0 1e+00 LOC102551633
Time in open arm before self-admin 28.75 1 1 100 0 1e+00 LOC102551633
Time in open arm after self-admin 5.82 1 0 0 0 1e+00 LOC102551633
Sum of active levers in priming session hrs 5-6 18.99 1 0 0 0 1e+00 LOC102551633
Time to tail flick, vehicle, before self-admin 53.6 1 1 100 0 1e+00 LOC102551633
Time to tail flick, vehicle, after self-admin 51.7 1 1 100 0 1e+00 LOC102551633
Time to tail flick, test, before self-admin 4.05 1 0 0 0 1e+00 LOC102551633
Delta time to tail flick, vehicle, before/after SA 122.63 1 1 100 0 1e+00 LOC102551633
Ambulatory time before self-admin 11.05 1 0 0 0 1e+00 LOC102551633
Ambulatory time after self-admin 16.68 1 0 0 0 1e+00 LOC102551633
Total heroin consumption 30.8 1 1 100 0 1e+00 LOC102551633
Rest time, locomotor task time 1 4 1 0 0 0 1e+00 LOC102551633
Bouts of movement, locomotor time 2 3.92 1 0 0 0 1e+00 LOC102551633
Seeking ratio, delayed vs. immediate footshock 9.35 1 0 0 0 1e+00 LOC102551633
Co content in liver 12.69 1 0 0 0 1e+00 LOC102551633
Fe content in liver 7.51 1 0 0 0 1e+00 LOC102551633
K content in liver 11.66 1 0 0 0 1e+00 LOC102551633
Na content in liver 44.6 1 1 100 0 1e+00 LOC102551633
Rb content in liver 16.75 1 0 0 0 1e+00 LOC102551633
Se content in liver 12.37 1 0 0 0 1e+00 LOC102551633
Sr content in liver 5.32 1 0 0 0 1e+00 LOC102551633

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.06
Adipose alternative TSS 0 0 1.08
Adipose gene expression 0 0 1.1
Adipose isoform ratio 0 0 1.08
Adipose intron excision ratio 0 0 1.1
Adipose mRNA stability 0 0 1.06
BLA alternative polyA 0 0 1.17
BLA alternative TSS 0 0 1.05
BLA gene expression 0 0 1.06
BLA isoform ratio 0 0 1.14
BLA intron excision ratio 0 0 1.02
BLA mRNA stability 0 0 1.09
Brain alternative polyA 0 0 1.08
Brain alternative TSS 0 0 1.11
Brain gene expression 0 0 1.08
Brain isoform ratio 0 0 1.12
Brain intron excision ratio 0 0 1.06
Brain mRNA stability 0 0 1.1
Eye alternative polyA 0 0 1.29
Eye alternative TSS 0 0 1.03
Eye gene expression 0 0 1.15
Eye isoform ratio 0 0 1.12
Eye intron excision ratio 0 0 1.01
Eye mRNA stability 0 0 1.08
IL alternative polyA 0 0 1.04
IL alternative TSS 0 0 1.03
IL gene expression 0 0 1.08
IL isoform ratio 0 0 1.16
IL intron excision ratio 0 0 1.1
IL mRNA stability 0 0 1.17
LHb alternative polyA 0 0 1.14
LHb alternative TSS 0 0 1.24
LHb gene expression 0 0 1.07
LHb isoform ratio 0 0 1.22
LHb intron excision ratio 0 0 1.07
LHb mRNA stability 0 0 1.17
Liver alternative polyA 0 0 1.13
Liver alternative TSS 0 0 1.12
Liver gene expression 0 0 1.08
Liver isoform ratio 0 0 1.12
Liver intron excision ratio 0 0 1.08
Liver mRNA stability 0 0 1.05
NAcc alternative polyA 0 0 1.11
NAcc alternative TSS 0 0 1.1
NAcc gene expression 0 0 1.09
NAcc isoform ratio 0 0 1.12
NAcc intron excision ratio 0 0 1.08
NAcc mRNA stability 0 0 1.13
OFC alternative polyA 0 0 1.17
OFC alternative TSS 0 0 1.12
OFC gene expression 0 0 1.04
OFC isoform ratio 0 0 1.13
OFC intron excision ratio 0 0 1
OFC mRNA stability 0 0 1.13
PL alternative polyA 0 0 1.13
PL alternative TSS 0 0 1.11
PL gene expression 0 0 1.1
PL isoform ratio 0 0 1.16
PL intron excision ratio 0 0 1.12
PL mRNA stability 0 0 1.14
pVTA alternative polyA 0 0 1.21
pVTA alternative TSS 0 0 1.08
pVTA gene expression 0 0 1.1
pVTA isoform ratio 0 0 1.18
pVTA intron excision ratio 0 0 1.06
pVTA mRNA stability 0 0 1.18
RMTg alternative polyA 1 0.2 1.03
RMTg alternative TSS 0 0 1.19
RMTg gene expression 0 0 1.07
RMTg isoform ratio 0 0 1.13
RMTg intron excision ratio 0 0 1.01
RMTg mRNA stability 0 0 1.14