Hub : Traits

Cocaine induced anxiety

Post-drug hide time minus pre-drug hide time

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

3 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 46789397 48185455 1 1 1.6e-09 0.670 1.0e+00 100 Trim16
2 15 24291347 25661910 1 1 1.9e-08 0.031 4.9e-07 -443 Rab2b

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 1.4 1 0 0 0 1 Rab2b
Heart weight 7.8 1 0 0 0 1 Trim16
Liver weight, left 7.8 1 0 0 0 1 Trim16
Parametrial fat weight 3.0 1 0 0 0 1 Rab2b
Intraocular pressure 38.8 1 1 50 0 1 Trim16
Extensor digitorum longus weight 2.3 1 0 0 0 1 Rab2b
Tibialis anterior weight 1.9 1 0 0 0 1 Rab2b
Number of licking bursts 19.2 1 0 0 0 1 Trim16
Food consumed during 24 hour testing period 10.1 2 0 0 0 1 Trim16 Rab2b
Times rat made contact with spout 16.5 1 0 0 0 1 Trim16
Mean time between licks in bursts 5.1 1 0 0 0 1 Rab2b
Mean num. licks in bursts 46.0 1 1 50 0 1 Trim16
Std. dev. time between licks in bursts 5.4 1 0 0 0 1 Trim16
Water consumed over 24 hours 23.8 1 1 50 0 1 Trim16
Indifference point 0 sec 7.9 1 0 0 0 1 Trim16
Delay discounting total patch changes 0 sec 8.5 1 0 0 0 1 Trim16
Delay discounting total patch changes 18 sec 45.7 1 1 50 0 1 Trim16
Delay discounting total patch changes 24 sec 5.6 1 0 0 0 1 Rab2b
Delay discounting total patch changes 6 sec 5.0 1 0 0 0 1 Trim16
Delay discounting water rate 0 sec 15.1 1 0 0 0 1 Trim16
Delay discounting water rate 6 sec 7.2 1 0 0 0 1 Trim16
Locomotor activity 4.9 1 0 0 0 1 Trim16
Light reinforcement 1 3.9 1 0 0 0 1 Rab2b
Reaction time number correct 7.5 1 0 0 0 1 Trim16
Reaction time trials correct on left 7.5 1 0 0 0 1 Trim16
Reaction time trials on left 6.9 1 0 0 0 1 Trim16
Reaction time premature initiation rate 5.8 1 0 0 0 1 Trim16
Reaction time trials completed 6.9 1 0 0 0 1 Trim16
Reaction time trials AUC 6.0 1 0 0 0 1 Trim16
Social time 25.9 1 1 50 0 1 Trim16
Cocaine response after cond. corrected 14.6 1 0 0 0 1 Trim16
Cocaine response after cond. not corrected 16.0 1 0 0 0 1 Trim16
Condit. Reinf. lever presses 7.4 1 0 0 0 1 Trim16
Pavlov. Cond. intertrial magazine entries 4.8 1 0 0 0 1 Rab2b
Intermitt. access day 1 inactive lever presses 36.6 1 1 50 0 1 Trim16
Intermitt. access escalation Index 27.6 1 0 0 0 1 Trim16
Intermittent access day 15 total infusions 7.8 1 0 0 0 1 Rab2b
Intermittent access total infusions 8.8 1 0 0 0 1 Rab2b
Intermittent access day 1 locomotion 12.8 1 0 0 0 1 Trim16
Intermittent access total locomotion 7.7 2 0 0 0 1 Trim16 Rab2b
Intermittent access standard deviation 13.3 1 0 0 0 1 Rab2b
Post-drug Anxiety 16.0 2 0 0 0 1 Trim16 Rab2b
Baseline Anxiety 15.0 2 1 50 0 1 Trim16 Rab2b
Lifetime Intake 14.3 1 0 0 0 1 Rab2b
Progressive ratio test 1 inactive lever presses 18.5 2 1 50 0 1 Trim16 Rab2b
Progressive ratio test 2 active lever presses 6.2 1 0 0 0 1 Rab2b
Progressive ratio test 2 breakpoint 5.8 1 0 0 0 1 Rab2b
Progressive ratio test 2 inactive lever presses 6.0 1 0 0 0 1 Rab2b
Total sessions with >9 infusions 13.7 1 0 0 0 1 Trim16
Short access day 1 total inactive lever presses 13.8 1 0 0 0 1 Trim16
Short access day 10 total inactive lever presses 12.4 1 0 0 0 1 Rab2b
Short access day 1 total infusions 28.9 2 1 50 0 1 Trim16 Rab2b
Short access total infusions 10.2 1 0 0 0 1 Rab2b
Short access day 1 locomotion 33.1 1 1 50 0 1 Trim16
Short access day 10 total locomotion 14.3 1 0 0 0 1 Trim16
Short access total locomotion 7.8 2 0 0 0 1 Trim16 Rab2b
Compulsive drug intake 11.9 1 0 0 0 1 Trim16
One hour access (0.3 mA shock) 7.8 1 0 0 0 1 Rab2b
One hour access (shock baseline) 16.4 1 0 0 0 1 Rab2b
Number of responses in last shaping day 16.3 2 1 50 0 1 Trim16 Rab2b
Context. condit. distance diff. score 5.0 1 0 0 0 1 Trim16
Locomotion distance, session 1 31.9 1 1 50 0 1 Trim16
Locomotion distance, session 2 15.7 1 0 0 0 1 Trim16
Stereotopy head waving bouts, day 7 25.4 1 1 50 0 1 Trim16
Stereotopy head waving duration, day 7 6.5 1 0 0 0 1 Trim16
Degree of sensitization stereotypy 7.4 1 0 0 0 1 Trim16
Incentive salience index mean 5.9 1 0 0 0 1 Trim16
Time in familiar zone, hab. session 1 6.6 1 0 0 0 1 Trim16
Total zone transitions, hab. session 1 37.4 1 1 50 0 1 Trim16
Total locomotion distance, hab. session 1 38.5 1 1 50 0 1 Trim16
Locomotion velocity, hab. session 1 30.2 1 1 50 0 1 Trim16
Time in familiar zone, hab. session 2 8.6 1 0 0 0 1 Trim16
Total locomotion distance, hab. session 2 11.5 1 0 0 0 1 Trim16
Locomotion velocity, hab. session 2 10.0 1 0 0 0 1 Trim16
Total locomotion distance, NPP test 4.5 1 0 0 0 1 Trim16
Pavlov. Cond. magazine entry latency 30.9 1 1 50 0 1 Trim16
Pavlov. Cond. index score 10.8 1 0 0 0 1 Trim16
Pavlov. Cond. latency score 5.9 1 0 0 0 1 Trim16
Pavlov. Cond. magazine entry number 28.0 1 1 50 0 1 Trim16
Pavlov. Cond. intertrial magazine entries 14.4 1 0 0 0 1 Trim16
Pavlov. Cond. lever-magazine prob. diff. 10.2 1 0 0 0 1 Trim16
Pavlov. Cond. response bias 8.3 1 0 0 0 1 Trim16
Bone: cortical apparent density 18.1 1 0 0 0 1 Trim16
Bone: cortical porosity 21.5 1 0 0 0 1 Trim16
Bone: cortical porosity 27.4 1 1 50 0 1 Trim16
Bone: cortical tissue density 19.6 1 0 0 0 1 Trim16
Bone: elastic work 5.8 1 0 0 0 1 Trim16
Bone: post-yield work 16.2 1 0 0 0 1 Trim16
Bone: tissue strength 7.4 1 0 0 0 1 Trim16
Distance traveled before self-admin 11.2 1 0 0 0 1 Rab2b
Distance traveled after self-admin 6.9 1 0 0 0 1 Rab2b
Time in closed arm after self-admin 8.7 1 0 0 0 1 Rab2b
Time to tail flick, test, after self-admin 9.3 1 0 0 0 1 Rab2b
Ambulatory time before self-admin 14.1 1 0 0 0 1 Rab2b
Ambulatory time after self-admin 5.9 1 0 0 0 1 Rab2b
Delay disc. indifference point, 16s delay 6.6 1 0 0 0 1 Trim16
Delay disc. indifference point, 24s delay 11.5 1 0 0 0 1 Rab2b
Time >=10cm from walls, locomotor time 1 13.7 1 0 0 0 1 Rab2b
Bouts of movement, locomotor time 1 5.5 1 0 0 0 1 Rab2b
Bouts of movement, locomotor time 2 6.8 1 0 0 0 1 Rab2b
Total resting periods, locomotor time 2 5.9 1 0 0 0 1 Rab2b
Distance moved, locomotor task time 2 6.6 1 0 0 0 1 Trim16
Run reversals in cocaine runway, females 11.6 1 0 0 0 1 Trim16
Run reversals in cocaine runway, males 6.2 1 0 0 0 1 Trim16
Latency to leave start box in cocaine runway 10.8 2 0 0 0 1 Trim16 Rab2b
Latency to leave start box in cocaine runway, F 7.3 1 0 0 0 1 Trim16
Latency to leave start box in cocaine runway, M 6.4 1 0 0 0 1 Rab2b
Cu content in liver 6.2 1 0 0 0 1 Trim16
K content in liver 8.3 1 0 0 0 1 Trim16
Mg content in liver 28.9 1 1 50 0 1 Trim16
Rb content in liver 24.8 1 1 50 0 1 Trim16
Se content in liver 19.8 1 0 0 0 1 Trim16

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 2 0.094 1.3
Adipose alternative TSS 0 0.000 1.1
Adipose gene expression 0 0.000 1.1
Adipose isoform ratio 0 0.000 1.2
Adipose intron excision ratio 0 0.000 1.2
Adipose mRNA stability 0 0.000 1.1
BLA alternative polyA 0 0.000 1.1
BLA alternative TSS 0 0.000 1.2
BLA gene expression 0 0.000 1.1
BLA isoform ratio 0 0.000 1.2
BLA intron excision ratio 0 0.000 1.2
BLA mRNA stability 0 0.000 1.2
Brain alternative polyA 0 0.000 1.2
Brain alternative TSS 0 0.000 1.2
Brain gene expression 0 0.000 1.1
Brain isoform ratio 0 0.000 1.2
Brain intron excision ratio 0 0.000 1.2
Brain mRNA stability 0 0.000 1.1
Eye alternative polyA 0 0.000 1.3
Eye alternative TSS 0 0.000 1.2
Eye gene expression 0 0.000 1.1
Eye isoform ratio 0 0.000 1.3
Eye intron excision ratio 0 0.000 1.2
Eye mRNA stability 0 0.000 1.3
IL alternative polyA 0 0.000 1.1
IL alternative TSS 0 0.000 1.3
IL gene expression 0 0.000 1.1
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 0 0.000 1.1
IL mRNA stability 0 0.000 1.1
LHb alternative polyA 0 0.000 1.1
LHb alternative TSS 0 0.000 1.1
LHb gene expression 0 0.000 1.2
LHb isoform ratio 0 0.000 1.1
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.2
Liver alternative polyA 0 0.000 1.2
Liver alternative TSS 0 0.000 1.2
Liver gene expression 0 0.000 1.1
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.2
Liver mRNA stability 0 0.000 1.2
NAcc alternative polyA 0 0.000 1.1
NAcc alternative TSS 0 0.000 1.2
NAcc gene expression 0 0.000 1.1
NAcc isoform ratio 0 0.000 1.2
NAcc intron excision ratio 0 0.000 1.2
NAcc mRNA stability 0 0.000 1.2
OFC alternative polyA 0 0.000 1.0
OFC alternative TSS 0 0.000 1.2
OFC gene expression 0 0.000 1.1
OFC isoform ratio 0 0.000 1.1
OFC intron excision ratio 0 0.000 1.2
OFC mRNA stability 0 0.000 1.2
PL alternative polyA 0 0.000 1.1
PL alternative TSS 0 0.000 1.3
PL gene expression 1 0.014 1.1
PL isoform ratio 0 0.000 1.2
PL intron excision ratio 0 0.000 1.2
PL mRNA stability 0 0.000 1.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.