Hub : Traits

Cocaine induced anxiety

Post-drug hide time minus pre-drug hide time

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr9	75969545	77365260	1	1	2.67e-33	1.22e-01	1e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	100	0	1e+00	Zfand2b
BMI without tail	53.65	1	1	100	0	1e+00	Zfand2b
Epididymis fat weight	111.28	1	1	100	0	1e+00	Zfand2b
Heart weight	71.7	1	1	100	0	1e+00	Zfand2b
Left kidney weight	27.22	1	1	100	0	1e+00	Zfand2b
Right kidney weight	54.05	1	1	100	0	1e+00	Zfand2b
Tail length	125.62	1	1	100	0	1e+00	Zfand2b
Length with tail	4.78	1	0	0	0	1e+00	Zfand2b
Length without tail	77.43	1	1	100	0	1e+00	Zfand2b
Liver weight, left	2.4	1	0	0	0	1e+00	Zfand2b
Liver weight, right	17.57	1	1	100	0	1e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1e+00	Zfand2b
Retroperitoneal fat weight	7.53	1	0	0	0	1e+00	Zfand2b
Intraocular pressure	51.69	1	1	100	0	1e+00	Zfand2b
Tibialis anterior weight	1.65	1	0	0	0	1e+00	Zfand2b
Number of licking bursts	32.5	1	1	100	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	100	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	11.8	1	0	0	0	1e+00	Zfand2b
Patch foraging indifference point AUC	24.2	1	1	100	0	1e+00	Zfand2b
Indifference point function ln k	54.42	1	1	100	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	100	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	23.48	1	1	100	0	1e+00	Zfand2b
Patch foraging total patch changes 12 sec	4.29	1	0	0	0	1e+00	Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	100	0	1e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	100	0	1e+00	Zfand2b
Patch foraging total patch changes 6 sec	24.67	1	1	100	0	1e+00	Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	100	0	1e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	100	0	1e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	100	0	1e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	100	0	1e+00	Zfand2b
Locomotor activity	12.38	1	0	0	0	1e+00	Zfand2b
Locomotor testing distance	47.2	1	1	100	0	1e+00	Zfand2b
Locomotor testing rearing	99.51	1	1	100	0	1e+00	Zfand2b
Light reinforcement 1	19.25	1	1	100	0	1e+00	Zfand2b
Light reinforcement 2	6.57	1	0	0	0	1e+00	Zfand2b
Reaction time number correct	114.79	1	1	100	0	1e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	100	0	1e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	100	0	1e+00	Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	100	0	1e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	100	0	1e+00	Zfand2b
Reaction time trials on left	106.69	1	1	100	0	1e+00	Zfand2b
Reaction time mean	36.11	1	1	100	0	1e+00	Zfand2b
Reaction time mean AUC	33.75	1	1	100	0	1e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1e+00	Zfand2b
Reaction time omissions	46.56	1	1	100	0	1e+00	Zfand2b
Reaction time false alarm rate	3.92	1	0	0	0	1e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	100	0	1e+00	Zfand2b
Std. dev. reaction times	72.92	1	1	100	0	1e+00	Zfand2b
Reaction time trials completed	106.69	1	1	100	0	1e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	100	0	1e+00	Zfand2b
Social response proportion	6.01	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. corrected	12.71	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. active minus inactive responses	3.61	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. active-inactive response ratio	4.76	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. active responses	2.9	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever reinforcers received	2.89	1	0	0	0	1e+00	Zfand2b
Pavlov. Cond. intertrial magazine entries	3.16	1	0	0	0	1e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	100	0	1e+00	Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	100	0	1e+00	Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1e+00	Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	100	0	1e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	100	0	1e+00	Zfand2b
Intermitt. access day 1 inactive lever presses	169.63	1	1	100	0	1e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	294.26	1	1	100	0	1e+00	Zfand2b
Intermitt. access escalation Index	5.01	1	0	0	0	1e+00	Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	100	0	1e+00	Zfand2b
Intermittent access day 15 total infusions	35.39	1	1	100	0	1e+00	Zfand2b
Intermittent access terminal intake (last 3 days)	25.82	1	1	100	0	1e+00	Zfand2b
Intermittent access day 1 locomotion	26.47	1	1	100	0	1e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	100	0	1e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1e+00	Zfand2b
Intermittent access standard deviation	442.51	1	1	100	0	1e+00	Zfand2b
Baseline Anxiety	393.92	1	1	100	0	1e+00	Zfand2b
Incentive Sensitization - Responses	309.83	1	1	100	0	1e+00	Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	100	0	1e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	100	0	1e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1e+00	Zfand2b
Progressive ratio test 2 active lever presses	109.22	1	1	100	0	1e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	100	0	1e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	100	0	1e+00	Zfand2b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	100	0	1e+00	Zfand2b
Short access day 1 total infusions	3.85	1	0	0	0	1e+00	Zfand2b
Short access day 10 total infusions	4.07	1	0	0	0	1e+00	Zfand2b
Short access day 1 locomotion	129.19	1	1	100	0	1e+00	Zfand2b
Short access day 10 total locomotion	432.47	1	1	100	0	1e+00	Zfand2b
Short access total locomotion	209.96	1	1	100	0	1e+00	Zfand2b
Compulsive drug intake	68.39	1	1	100	0	1e+00	Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1e+00	Zfand2b
Number of responses in last shaping day	67.75	1	1	100	0	1e+00	Zfand2b
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Time in familiar zone, hab. session 1	4.15	1	0	0	0	1e+00	Zfand2b
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Bone: maximum moment	2.64	1	0	0	0	1e+00	Zfand2b
Breakpoint value in progressive ratio session	4.44	1	0	0	0	1e+00	Zfand2b
Distance traveled before self-admin	5.58	1	0	0	0	1e+00	Zfand2b
Distance traveled after self-admin	8.9	1	0	0	0	1e+00	Zfand2b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1e+00	Zfand2b
Delta ambulatory time before/after self-admin	6.19	1	0	0	0	1e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	100	0	1e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.97	1	0	0	0	1e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	75.62	1	1	100	0	1e+00	Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1e+00	Zfand2b
Time to tail flick, test, after self-admin	5.63	1	0	0	0	1e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	100	0	1e+00	Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1e+00	Zfand2b
Ambulatory time after self-admin	4.73	1	0	0	0	1e+00	Zfand2b
Area under the delay curve	31.15	1	1	100	0	1e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	100	0	1e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	100	0	1e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	100	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	100	0	1e+00	Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1e+00	Zfand2b
Rest time, locomotor task time 1	11.47	1	0	0	0	1e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	100	0	1e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	100	0	1e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	100	0	1e+00	Zfand2b
Distance moved, locomotor task time 2	83.87	1	1	100	0	1e+00	Zfand2b
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1e+00	Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.74	1	0	0	0	1e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1e+00	Zfand2b
Seeking ratio, punishment vs. effort	4.29	1	0	0	0	1e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	100	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	100	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	100	0	1e+00	Zfand2b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.22
Adipose	alternative TSS	0	0	1.14
Adipose	gene expression	0	0	1.12
Adipose	isoform ratio	0	0	1.16
Adipose	intron excision ratio	0	0	1.13
Adipose	mRNA stability	0	0	1.12
BLA	alternative polyA	0	0	1.1
BLA	alternative TSS	0	0	1.19
BLA	gene expression	0	0	1.14
BLA	isoform ratio	0	0	1.14
BLA	intron excision ratio	0	0	1.19
BLA	mRNA stability	0	0	1.13
Brain	alternative polyA	0	0	1.1
Brain	alternative TSS	0	0	1.2
Brain	gene expression	0	0	1.12
Brain	isoform ratio	0	0	1.15
Brain	intron excision ratio	0	0	1.15
Brain	mRNA stability	0	0	1.13
Eye	alternative polyA	0	0	1.27
Eye	alternative TSS	0	0	1.07
Eye	gene expression	0	0	1.12
Eye	isoform ratio	0	0	1.12
Eye	intron excision ratio	0	0	1.27
Eye	mRNA stability	0	0	1.19
IL	alternative polyA	0	0	1.2
IL	alternative TSS	0	0	1.03
IL	gene expression	0	0	1.16
IL	isoform ratio	0	0	1.13
IL	intron excision ratio	0	0	1.08
IL	mRNA stability	0	0	1.14
LHb	alternative polyA	0	0	1.28
LHb	alternative TSS	0	0	1.33
LHb	gene expression	0	0	1.18
LHb	isoform ratio	0	0	1.19
LHb	intron excision ratio	0	0	1.34
LHb	mRNA stability	0	0	1.19
Liver	alternative polyA	0	0	1.23
Liver	alternative TSS	0	0	1.07
Liver	gene expression	0	0	1.13
Liver	isoform ratio	0	0	1.13
Liver	intron excision ratio	0	0	1.2
Liver	mRNA stability	0	0	1.11
NAcc	alternative polyA	0	0	1.14
NAcc	alternative TSS	0	0	1.2
NAcc	gene expression	0	0	1.13
NAcc	isoform ratio	0	0	1.16
NAcc	intron excision ratio	0	0	1.2
NAcc	mRNA stability	0	0	1.14
OFC	alternative polyA	0	0	1.2
OFC	alternative TSS	0	0	1.03
OFC	gene expression	0	0	1.15
OFC	isoform ratio	0	0	1.2
OFC	intron excision ratio	0	0	1.28
OFC	mRNA stability	0	0	1.18
PL	alternative polyA	0	0	1.14
PL	alternative TSS	0	0	1.25
PL	gene expression	0	0	1.14
PL	isoform ratio	0	0	1.2
PL	intron excision ratio	1	0	1.21
PL	mRNA stability	0	0	1.12
pVTA	alternative polyA	0	0	1.17
pVTA	alternative TSS	0	0	1.21
pVTA	gene expression	0	0	1.18
pVTA	isoform ratio	0	0	1.21
pVTA	intron excision ratio	0	0	1.23
pVTA	mRNA stability	0	0	1.17
RMTg	alternative polyA	0	0	1.11
RMTg	alternative TSS	0	0	1.33
RMTg	gene expression	0	0	1.16
RMTg	isoform ratio	0	0	1.14
RMTg	intron excision ratio	0	0	1.31
RMTg	mRNA stability	0	0	1.09