Hub : Genes

Rnf169

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Rnf169	0.03	0.03	2.5e-03	0.02	0.01	0.01	0.01	1.9e-03	1.5e-02	1.9e-02	6.9e-03
2	NAcc	gene expression	Rnf169	0.03	0.02	6.3e-03	0.01	0.01	0.01	0.01	1.3e-02	6.4e-02	1.7e-02	2.7e-02
3	PL	gene expression	Rnf169	0.03	0.03	2.5e-03	0.02	0.02	0.02	0.02	1.0e-03	2.2e-03	2.1e-03	2.1e-03
4	pVTA	gene expression	Rnf169	0.08	0.06	5.8e-03	0.02	0.04	0.03	0.03	4.6e-02	5.5e-03	1.5e-02	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.3	0.6	0.4	0.4	0.4	-0.8
Area under the delay curve	0.0	0.0	0.1	0.0	0.0	0.0	0.3
BMI with tail	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.5
BMI without tail	1.4	2.9	5.7	-1.4	-1.4	-1.4	2.4
Body weight	0.7	3.0	7.0	-1.3	-1.3	-1.3	2.6
Weight adjusted by age	1.1	1.3	1.9	-1.0	-1.0	-1.0	1.4
Bone surface	0.8	1.4	1.6	-1.3	-1.3	-1.3	0.9
Bone volume	0.4	0.7	0.9	-0.9	-0.9	-0.9	0.6
Breakpoint value in progressive ratio session	0.4	0.4	0.6	0.6	0.6	0.6	-0.8
Number of licking bursts	3.8	4.5	5.5	2.3	2.3	2.3	-1.2
Context. condit. distance diff. score	1.5	1.9	2.4	-1.5	-1.5	-1.5	0.5
Locomotion velocity, session 1	0.6	0.6	1.1	0.7	0.7	0.7	-1.1
Locomotion distance, session 1	0.3	0.4	0.6	-0.8	-0.8	-0.8	0.0
Locomotion velocity, session 2	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3
Locomotion distance, session 2	0.3	0.4	0.5	-0.7	-0.7	-0.7	0.2
Locomotion velocity, session 3	0.2	0.2	0.3	-0.6	-0.6	-0.6	-0.2
Locomotion distance, session 3	0.5	0.5	0.7	-0.8	-0.8	-0.8	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	0.4	0.4	0.4	0.3
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1
Locomotion velocity, session 7	0.4	0.4	0.5	0.6	0.6	0.6	-0.7
Locomotion distance, session 7	0.1	0.1	0.1	0.4	0.4	0.4	-0.2
Stereotopy head waving bouts, day 7	1.8	2.0	2.6	-1.6	-1.6	-1.6	0.7
Stereotopy head waving duration, day 7	2.7	3.2	3.9	-2.0	-2.0	-2.0	1.1
Locomotion velocity, session 8	0.5	0.7	0.8	-0.9	-0.9	-0.9	0.4
Locomotion distance, session 8	1.7	2.6	3.2	-1.8	-1.8	-1.8	0.8
Degree of sensitization distance	0.3	0.3	1.0	0.2	0.2	0.2	1.0
Degree of sensitization stereotypy	4.2	4.6	5.8	-2.4	-2.4	-2.4	1.1
Conditioned locomotion	0.2	0.2	0.4	0.4	0.4	0.4	-0.6
Cocaine response after cond. corrected	1.1	1.2	1.6	1.3	1.3	1.3	-0.3
Cocaine response after cond. not corrected	0.3	0.4	0.5	0.7	0.7	0.7	-0.2
Cocaine response before conditioning	0.8	1.0	1.3	-1.2	-1.2	-1.2	0.1
Saline control response	2.8	3.6	3.8	-1.9	-1.9	-1.9	1.8
Bone: connectivity density	0.1	0.2	0.5	0.2	0.2	0.2	-0.7
Bone: cortical apparent density	1.1	1.5	1.9	1.4	1.4	1.4	-0.5
Bone: cortical area	0.6	0.9	1.0	-0.9	-0.9	-0.9	1.0
Bone: cortical porosity	0.4	0.4	0.5	-0.7	-0.7	-0.7	-0.1
Bone: cortical porosity	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.2
Bone: cortical thickness	0.2	0.3	0.3	0.5	0.5	0.5	-0.5
Bone: cortical thickness	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.1
Bone: cortical tissue density	1.2	1.6	2.0	1.4	1.4	1.4	-0.5
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	-0.6	-0.6	-0.6	0.9
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.7	-1.0	-1.0	-1.0	1.3
Condit. Reinf. active responses	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.4
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	0.3	0.3	-0.4
Incentive salience index mean	0.5	0.6	0.8	-0.7	-0.7	-0.7	0.9
Condit. Reinf. lever presses	0.2	0.2	0.2	-0.5	-0.5	-0.5	0.5
Condit. Reinf. active minus inactive responses	9.8	12.2	13.0	-3.6	-3.6	-3.6	3.1
Condit. Reinf. active-inactive response ratio	2.1	2.2	2.5	-1.6	-1.6	-1.6	1.2
Condit. Reinf. active responses	13.1	18.1	18.9	-4.3	-4.3	-4.3	4.0
Condit. Reinf. inactive responses	7.8	9.7	9.8	-3.1	-3.1	-3.1	3.0
Condit. Reinf. lever presses	21.0	28.5	31.8	-5.6	-5.6	-5.6	4.3
Condit. Reinf. lever reinforcers received	14.2	19.9	21.1	-4.6	-4.6	-4.6	4.0
Conditioned reinforcement - actives	2.1	2.1	2.8	-1.7	-1.7	-1.7	0.4
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.2	0.2	0.2	0.0
Conditioned locomotion	1.4	1.7	2.2	-1.5	-1.5	-1.5	-0.1
Patch foraging indifference point 0 sec	4.2	6.8	7.7	-2.8	-2.8	-2.8	2.1
Patch foraging indifference point AUC	0.4	0.4	0.9	-0.5	-0.5	-0.5	1.0
Delay disc. indifference point, 0s delay	1.1	1.2	1.2	-1.1	-1.1	-1.1	0.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.3	0.3	-0.3
Delay disc. indifference point, 2s delay	1.4	1.5	2.1	-1.2	-1.2	-1.2	1.4
Delay disc. indifference point, 24s delay	1.0	0.9	1.0	1.0	1.0	1.0	-0.8
Delay disc. indifference point, 4s delay	1.6	1.7	2.3	-1.2	-1.2	-1.2	1.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.3
Indifference point function ln k	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.4
Indifference point function log k	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.4
Patch foraging total patch changes 0 sec	3.5	5.7	6.3	-2.5	-2.5	-2.5	1.9
Patch foraging total patch changes 12 sec	2.5	3.2	3.6	-1.8	-1.8	-1.8	1.9
Patch foraging total patch changes 18 sec	3.1	4.0	4.2	-2.1	-2.1	-2.1	1.8
Patch foraging total patch changes 24 sec	1.8	2.2	2.4	-1.5	-1.5	-1.5	1.6
Patch foraging total patch changes 6 sec	0.7	1.0	1.2	-1.1	-1.1	-1.1	0.6
Patch foraging time to switch 0 sec	4.1	6.3	6.7	2.6	2.6	2.6	-2.2
Patch foraging water rate 0 sec	3.1	5.0	5.7	-2.4	-2.4	-2.4	1.6
Patch foraging water rate 12 sec	1.2	1.9	2.3	-1.5	-1.5	-1.5	0.7
Patch foraging water rate 18 sec	1.3	1.7	1.9	-1.4	-1.4	-1.4	1.1
Patch foraging water rate 24 sec	0.3	0.4	0.6	-0.8	-0.8	-0.8	-0.3
Patch foraging water rate 6 sec	0.5	0.8	1.0	-1.0	-1.0	-1.0	0.2
Seeking ratio, delayed vs. immediate footshock	2.3	2.7	2.8	1.7	1.7	1.7	-1.6
Distance traveled before self-admin	0.7	0.8	0.9	0.9	0.9	0.9	-0.6
Distance traveled after self-admin	1.3	1.5	2.9	1.0	1.0	1.0	-1.7
Extensor digitorum longus weight	0.1	0.3	1.0	-0.1	-0.1	-0.1	1.0
Bone: elastic displacement	3.2	3.6	3.7	1.9	1.9	1.9	-1.8
Bone: elastic work	3.1	4.0	4.2	2.0	2.0	2.0	-2.0
Bone: endosteal estimation	2.1	4.6	5.7	-2.1	-2.1	-2.1	2.4
Bone: endosteal perimeter	2.6	5.4	6.1	-2.3	-2.3	-2.3	2.5
Epididymis fat weight	0.2	0.4	1.6	0.2	0.2	0.2	1.3
Delta time in closed arm before/after self-admin	0.4	0.3	0.8	0.4	0.4	0.4	0.9
Delta time in open arm before/after self-admin	3.4	3.2	3.6	-1.9	-1.9	-1.9	1.5
Diff in mean of infusions in LGA sessions	2.7	3.0	3.5	1.9	1.9	1.9	-1.2
Delay discount exponential model param	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.3
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.2	0.2	0.2	0.0
Active lever presses in extinction session 6	0.8	0.7	0.9	-1.0	-1.0	-1.0	-0.3
Bone: final force	0.0	0.0	0.0	0.1	0.1	0.1	-0.0
Bone: final moment	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.2
Food consumed during 24 hour testing period	2.7	3.3	4.1	-2.0	-2.0	-2.0	1.0
Glucose	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.2
Heart weight	1.1	1.5	1.8	-1.3	-1.3	-1.3	0.8
Delay discount hyperbolic model param	0.1	0.1	0.3	0.2	0.2	0.2	-0.6
Intermittent access intake day 1-15 change	0.5	0.5	0.7	-0.8	-0.8	-0.8	0.3
Intermittent access intake escalation	0.6	0.6	0.8	-0.9	-0.9	-0.9	0.3
Intermittent access intake escalation 2	0.5	0.5	0.5	-0.7	-0.7	-0.7	0.5
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.2	0.5	0.5	0.5	-0.1
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.3
Intermitt. access escalation Index	0.3	0.3	0.3	-0.6	-0.6	-0.6	0.3
Intermittent access day 1 total infusions	1.3	1.5	1.7	-1.3	-1.3	-1.3	1.0
Intermittent access day 15 total infusions	1.4	1.5	1.9	-1.4	-1.4	-1.4	0.6
Intermittent access terminal intake (last 3 days)	1.6	1.8	2.2	-1.5	-1.5	-1.5	0.8
Intermittent access total infusions	1.2	1.3	1.5	-1.2	-1.2	-1.2	0.7
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2
Intermittent access day 15 total locomotion	1.0	1.1	1.4	-1.2	-1.2	-1.2	0.3
Intermittent access total locomotion	0.6	0.7	0.8	-0.9	-0.9	-0.9	0.4
Intermittent access standard deviation	0.3	0.3	0.3	-0.5	-0.5	-0.5	0.5
Left kidney weight	1.8	5.1	7.6	-2.1	-2.1	-2.1	2.8
Right kidney weight	1.1	3.2	4.6	-1.6	-1.6	-1.6	2.2
Cocaine induced anxiety	2.0	2.4	2.7	1.6	1.6	1.6	-1.1
Post-drug Anxiety	0.6	0.6	0.8	0.9	0.9	0.9	-0.4
Baseline Anxiety	1.2	1.3	1.3	-1.2	-1.2	-1.2	1.1
Tail length	4.1	12.5	20.7	-3.1	-3.1	-3.1	4.5
Length with tail	1.6	5.8	12.0	-2.0	-2.0	-2.0	3.5
Length without tail	0.3	0.6	0.7	0.8	0.8	0.8	-0.6
Times rat made contact with spout	0.1	0.1	0.3	0.2	0.2	0.2	0.5
Lifetime Intake	1.3	1.5	1.8	-1.3	-1.3	-1.3	0.8
Liver weight, left	0.2	0.3	0.7	0.4	0.4	0.4	0.8
Liver weight, right	0.3	0.6	1.1	0.6	0.6	0.6	1.1
Locomotor activity	0.5	0.8	1.0	-1.0	-1.0	-1.0	0.5
Locomotor testing distance	2.3	3.8	4.1	-2.0	-2.0	-2.0	1.7
Locomotor testing rearing	1.3	1.9	3.1	-1.2	-1.2	-1.2	1.8
Locomotion in novel chamber	0.3	0.4	0.4	-0.7	-0.7	-0.7	-0.5
Locomotion in novel chamber post-restriction	1.1	1.4	1.8	-1.3	-1.3	-1.3	0.3
Fecal boli incidents, locomotor time 1	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.1
Change in fecal boli incidents, locomotor task	0.9	0.9	1.0	1.0	1.0	1.0	-0.7
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.3	-1.1	-1.1	-1.1	0.4
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.1	-0.1	-0.1	-0.5
Rest time, locomotor task time 1	0.2	0.3	0.6	0.4	0.4	0.4	-0.8
Distance moved, locomotor task time 1	0.6	0.7	1.4	-0.7	-0.7	-0.7	1.2
Vertical activity count, locomotor time 1	0.6	0.6	1.2	-0.7	-0.7	-0.7	1.1
Time >=10cm from walls, locomotor time 2	1.6	1.7	1.9	-1.4	-1.4	-1.4	1.0
Bouts of movement, locomotor time 2	1.0	1.1	1.3	-1.0	-1.0	-1.0	1.1
Total resting periods, locomotor time 2	0.4	0.5	0.7	-0.6	-0.6	-0.6	0.9
Rest time, locomotor task time 2	4.0	4.5	5.1	2.3	2.3	2.3	-1.7
Distance moved, locomotor task time 2	4.6	5.3	5.7	-2.4	-2.4	-2.4	2.1
Vertical activity count, locomotor time 2	2.3	2.5	2.9	-1.5	-1.5	-1.5	1.7
Light reinforcement 1	2.5	4.5	5.6	2.4	2.4	2.4	-1.2
Light reinforcement 2	0.6	0.8	0.8	0.9	0.9	0.9	-0.9
Bone: marrow area	1.8	3.9	5.1	-1.9	-1.9	-1.9	2.3
Bone: maximum diameter	2.5	4.6	4.6	-2.2	-2.2	-2.2	2.1
Bone: maximum force	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.2
Bone: maximum moment	0.1	0.2	0.2	-0.5	-0.5	-0.5	0.4
Mean time between licks in bursts	8.0	11.3	13.4	-3.2	-3.2	-3.2	3.7
Mean num. licks in bursts	3.4	4.1	4.9	-2.2	-2.2	-2.2	1.3
Cd content in liver	0.2	0.2	0.2	0.5	0.5	0.5	0.2
Co content in liver	2.3	2.7	3.1	-1.6	-1.6	-1.6	1.8
Cu content in liver	1.6	2.0	2.7	-1.3	-1.3	-1.3	1.6
Fe content in liver	0.0	0.0	0.0	0.1	0.1	0.1	0.1
K content in liver	0.1	0.1	0.1	0.3	0.3	0.3	0.3
Mg content in liver	0.2	0.2	0.3	-0.4	-0.4	-0.4	0.5
Mn content in liver	2.5	2.8	3.5	1.6	1.6	1.6	-1.9
Na content in liver	0.2	0.2	0.2	-0.5	-0.5	-0.5	0.2
Rb content in liver	0.9	1.1	1.2	-1.1	-1.1	-1.1	1.0
Se content in liver	4.2	5.1	5.6	2.4	2.4	2.4	-1.9
Sr content in liver	0.2	0.2	0.3	0.3	0.3	0.3	-0.6
Zn content in liver	5.4	5.9	6.7	-2.6	-2.6	-2.6	1.9
Bone: minimum diameter	1.1	2.1	4.2	-1.2	-1.2	-1.2	2.0
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.1	-0.1	-0.1	0.4
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.5	0.5	0.5	-0.3
Total zone transitions, hab. session 1	0.1	0.2	0.6	0.2	0.2	0.2	-0.8
Total locomotion distance, hab. session 1	0.2	0.2	0.4	0.5	0.5	0.5	0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.3	0.3	0.3	0.5
Time in familiar zone, hab. session 2	1.9	2.0	2.2	-1.5	-1.5	-1.5	1.2
Time in novel zone, hab. session 2	0.6	0.6	0.6	0.8	0.8	0.8	-0.8
Total zone transitions, hab. session 2	0.7	0.9	1.2	-1.1	-1.1	-1.1	0.2
Total locomotion distance, hab. session 2	0.4	0.6	1.6	-0.5	-0.5	-0.5	1.3
Locomotion velocity, hab. session 2	0.4	0.5	1.7	-0.4	-0.4	-0.4	1.3
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1
Novelty place preference	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1
Time in novel zone, NPP test	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.2
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3
Total locomotion distance, NPP test	0.1	0.1	0.4	0.2	0.2	0.2	0.7
Locomotion velocity, NPP test	0.2	0.3	0.3	0.5	0.5	0.5	0.4
Intraocular pressure	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.5
Delta distance traveled before/after self-admin	0.4	0.4	0.5	-0.7	-0.7	-0.7	-0.3
Delta ambulatory time before/after self-admin	0.3	0.3	0.3	-0.6	-0.6	-0.6	-0.5
Parametrial fat weight	0.4	0.8	1.0	1.0	1.0	1.0	0.5
Pavlov. Cond. lever latency	1.6	2.0	2.2	1.5	1.5	1.5	-1.2
Pavlov. Cond. magazine entry latency	3.7	4.8	5.1	-2.3	-2.3	-2.3	1.9
Pavlov. Cond. change in total contacts	1.9	2.0	2.1	-1.5	-1.5	-1.5	1.2
Pavlov. Cond. index score	3.9	4.9	5.3	-2.3	-2.3	-2.3	2.0
Pavlov. Cond. latency score	3.7	4.7	5.1	-2.3	-2.3	-2.3	1.9
Pavlov. Cond. lever contacts	1.9	2.3	2.3	-1.5	-1.5	-1.5	1.4
Pavlov. Cond. magazine entry number	4.0	5.0	5.5	2.3	2.3	2.3	-1.8
Pavlov. Cond. intertrial magazine entries	1.4	1.6	1.7	1.3	1.3	1.3	-1.2
Pavlov. Cond. lever-magazine prob. diff.	3.1	3.9	4.2	-2.0	-2.0	-2.0	1.7
Pavlov. Cond. response bias	1.7	2.1	2.2	-1.5	-1.5	-1.5	1.4
Pavlov. Cond. lever latency	20.5	27.7	31.3	5.6	5.6	5.6	-4.1
Pavlov. Cond. magazine entry latency	3.6	4.2	5.1	-2.3	-2.3	-2.3	1.3
Pavlov. Cond. change in total contacts	14.8	20.4	23.5	-4.8	-4.8	-4.8	3.3
Pavlov. Cond. index score	15.3	19.7	22.5	-4.7	-4.7	-4.7	3.4
Pavlov. Cond. latency score	13.5	16.8	19.3	-4.4	-4.4	-4.4	3.1
Pavlov. Cond. lever contacts	21.3	29.1	32.9	-5.7	-5.7	-5.7	4.2
Pavlov. Cond. magazine entry number	6.7	8.2	9.8	3.1	3.1	3.1	-1.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.5	-0.4	-0.4	-0.4	1.2
Pavlov. Cond. lever-magazine prob. diff.	14.7	18.8	21.2	-4.6	-4.6	-4.6	3.4
Pavlov. Cond. response bias	20.8	28.3	32.4	-5.7	-5.7	-5.7	4.0
Time in closed arm before self-admin	0.5	0.6	0.7	-0.8	-0.8	-0.8	-0.8
Time in closed arm after self-admin	1.3	1.4	2.3	1.0	1.0	1.0	-1.5
Time in open arm before self-admin	2.8	3.1	3.9	2.0	2.0	2.0	-0.8
Time in open arm after self-admin	0.9	1.0	2.3	-0.7	-0.7	-0.7	1.5
Bone: periosteal estimation	1.8	3.8	4.5	-1.9	-1.9	-1.9	2.1
Bone: periosteal perimeter	2.0	3.3	3.6	-1.8	-1.8	-1.8	1.9
Bone: post-yield work	0.1	0.2	0.2	-0.5	-0.5	-0.5	0.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.4	0.4	0.4	-0.4
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	0.2	0.2	0.2	-0.2
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.4	-0.5	-0.5	-0.5	0.6
Progressive ratio test 2 active lever presses	1.3	1.4	1.5	-1.2	-1.2	-1.2	1.1
Progressive ratio test 2 breakpoint	1.4	1.6	1.7	-1.3	-1.3	-1.3	1.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.8	-0.9	-0.9	-0.9	0.4
Incentive Sensitization - Responses	3.3	3.4	3.7	-1.9	-1.9	-1.9	1.6
Incentive Sensitization - Breakpoint	2.9	2.9	3.3	-1.8	-1.8	-1.8	1.4
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	0.4	0.4	0.4	-0.4
Progressive ratio	0.0	0.0	0.1	0.1	0.1	0.1	-0.3
Food seeking constrained by brief footshock	1.9	2.3	2.8	-1.5	-1.5	-1.5	1.7
Seeking ratio, punishment vs. effort	1.7	2.1	3.1	-1.3	-1.3	-1.3	1.8
Retroperitoneal fat weight	0.8	2.7	2.8	1.7	1.7	1.7	1.5
Reaction time number correct	0.3	0.4	1.3	0.4	0.4	0.4	-1.1
Reaction time mean minus median	0.9	1.1	1.4	-1.0	-1.0	-1.0	1.2
Reaction time mean minus median AUC	0.8	1.1	1.2	-1.1	-1.1	-1.1	0.9
Reaction time num false alarms	1.4	1.8	2.4	1.5	1.5	1.5	-0.5
Reaction time num false alarms AUC	0.8	1.1	1.4	1.2	1.2	1.2	-0.5
Reaction time trials correct on left	0.3	0.4	1.3	0.4	0.4	0.4	-1.1
Reaction time trials on left	0.3	0.4	1.3	0.4	0.4	0.4	-1.1
Reaction time mean	0.4	0.6	0.8	0.9	0.9	0.9	-0.1
Reaction time mean AUC	0.9	1.2	1.6	1.2	1.2	1.2	-0.4
Median of all reaction times	1.1	1.5	1.9	1.4	1.4	1.4	-0.6
Reaction time omissions	0.1	0.2	0.3	0.5	0.5	0.5	0.1
Reaction time false alarm rate	0.6	0.9	1.1	1.1	1.1	1.1	-0.1
Reaction time premature initiation rate	2.9	3.8	6.2	-1.7	-1.7	-1.7	2.5
Reaction time premature initiations	1.6	2.2	2.5	-1.4	-1.4	-1.4	1.6
Std. dev. reaction times	0.6	0.8	1.8	-0.7	-0.7	-0.7	1.3
Reaction time trials completed	0.3	0.4	1.3	0.4	0.4	0.4	-1.1
Reaction time trials AUC	0.2	0.3	0.9	0.3	0.3	0.3	-0.9
Run reversals in cocaine runway, females	0.8	0.8	3.1	-0.1	-0.1	-0.1	1.8
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.3	0.3	0.3	-0.3
Latency to leave start box in cocaine runway	1.8	2.0	2.6	1.6	1.6	1.6	-0.4
Latency to leave start box in cocaine runway, F	0.9	1.0	1.3	1.2	1.2	1.2	0.3
Latency to leave start box in cocaine runway, M	0.9	0.9	1.0	0.9	0.9	0.9	-1.0
Std. dev. time between licks in bursts	2.9	3.5	5.7	-1.7	-1.7	-1.7	2.4
Total sessions with >9 infusions	1.8	2.0	2.5	-1.6	-1.6	-1.6	0.7
Short access day 1 total inactive lever presses	0.3	0.3	0.4	0.6	0.6	0.6	-0.5
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.3	0.3	0.3	-0.5
Short access day 1 total infusions	2.9	3.1	3.5	-1.9	-1.9	-1.9	1.4
Short access day 10 total infusions	2.2	2.5	2.7	-1.7	-1.7	-1.7	1.3
Short access total infusions	1.2	1.3	1.4	-1.2	-1.2	-1.2	1.0
Short access day 1 locomotion	0.6	0.7	0.9	-1.0	-1.0	-1.0	0.0
Short access day 10 total locomotion	0.7	0.8	0.9	-0.9	-0.9	-0.9	0.6
Short access total locomotion	0.2	0.2	0.2	-0.5	-0.5	-0.5	0.2
One hour access (0.3 mA shock)	2.5	2.9	3.4	-1.9	-1.9	-1.9	1.1
Compulsive drug intake	0.2	0.2	0.4	0.4	0.4	0.4	-0.6
One hour access (shock baseline)	2.2	2.6	3.0	-1.7	-1.7	-1.7	1.1
Social response proportion	0.1	0.1	0.2	0.4	0.4	0.4	0.1
Social responses	0.1	0.2	0.5	0.2	0.2	0.2	0.7
Social time	3.8	5.0	5.5	2.3	2.3	2.3	-1.9
Soleus weight	0.3	0.9	3.2	-0.4	-0.4	-0.4	1.8
Bone: stiffness	0.0	0.1	0.1	0.2	0.2	0.2	0.3
Tibialis anterior weight	0.2	0.7	1.3	-0.7	-0.7	-0.7	1.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.2	0.2	0.2	-0.4
Time to tail flick, vehicle, after self-admin	1.2	1.3	1.6	-1.3	-1.3	-1.3	0.6
Time to tail flick, test, before self-admin	0.7	0.7	0.9	-0.8	-0.8	-0.8	0.9
Time to tail flick, test, after self-admin	1.1	1.2	1.9	-1.0	-1.0	-1.0	1.4
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	0.9	-1.0	-1.0	-1.0	0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	0.5	0.5	0.5	-0.2
Tibia length	0.9	2.6	3.4	-1.9	-1.9	-1.9	0.3
Ambulatory time before self-admin	1.1	1.1	1.1	1.1	1.1	1.1	-1.0
Ambulatory time after self-admin	1.3	1.4	3.7	0.8	0.8	0.8	-1.9
Bone: tissue strength	1.0	1.0	2.1	0.8	0.8	0.8	-1.4
Total heroin consumption	0.1	0.1	0.1	-0.4	-0.4	-0.4	0.0
Bone: trabecular number	1.4	2.2	2.7	1.4	1.4	1.4	-1.6
Bone: trabecular spacing	0.7	1.0	1.1	-1.1	-1.1	-1.1	0.7
Bone: trabecular thickness	0.1	0.2	0.2	0.5	0.5	0.5	-0.1
Bone: trabecular tissue density	0.4	0.5	0.6	0.7	0.7	0.7	0.6
Water consumed over 24 hours	0.8	1.0	1.0	1.0	1.0	1.0	-1.0
Number of responses in last shaping day	0.6	0.6	0.9	-0.7	-0.7	-0.7	1.0