Hub : Traits

Baseline Anxiety

Pre-drug hide time

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	1.36e-07	4.07e-02	2.61e-15	Syt5
2	10	46789397	48185455	1	1	1.87e-08	1.14e-01	1.00e+00	Trim16

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	2.58	1	0	0	0	1e+00	Syt5
Epididymis fat weight	2.21	1	0	0	0	1e+00	Syt5
Glucose	12.08	1	0	0	0	1e+00	Syt5
Heart weight	7.82	1	0	0	0	1e+00	Trim16
Right kidney weight	2.57	1	0	0	0	1e+00	Syt5
Length without tail	3.25	1	0	0	0	1e+00	Syt5
Liver weight, left	9	2	0	0	0	1e+00	Trim16 Syt5
Liver weight, right	11.2	1	0	0	0	1e+00	Syt5
Intraocular pressure	38.81	1	1	50	0	1e+00	Trim16
Tibialis anterior weight	2.35	1	0	0	0	1e+00	Syt5
Tibia length	7.53	1	0	0	0	1e+00	Syt5
Number of licking bursts	19.25	1	0	0	0	1e+00	Trim16
Food consumed during 24 hour testing period	18.56	1	0	0	0	1e+00	Trim16
Times rat made contact with spout	16.5	1	0	0	0	1e+00	Trim16
Mean num. licks in bursts	46	1	1	50	0	1e+00	Trim16
Std. dev. time between licks in bursts	14.05	2	1	50	0	1e+00	Trim16 Syt5
Water consumed over 24 hours	23.78	1	1	50	0	1e+00	Trim16
Indifference point 0 sec	7.13	2	0	0	0	1e+00	Trim16 Syt5
Indifference point function ln k	8.79	1	0	0	0	1e+00	Syt5
Indifference point function log k	8.79	1	0	0	0	1e+00	Syt5
Delay discounting total patch changes 0 sec	7.1	2	0	0	0	1e+00	Trim16 Syt5
Delay discounting total patch changes 18 sec	45.74	1	1	50	0	1e+00	Trim16
Delay discounting total patch changes 24 sec	10.35	1	0	0	0	1e+00	Syt5
Delay discounting total patch changes 6 sec	5.01	1	0	0	0	1e+00	Trim16
Delay discounting time to switch 0 sec	55.89	1	1	50	0	1e+00	Syt5
Delay discounting water rate 0 sec	12.7	2	0	0	0	1e+00	Trim16 Syt5
Delay discounting water rate 12 sec	22.12	1	1	50	0	1e+00	Syt5
Delay discounting water rate 18 sec	19.1	1	0	0	0	1e+00	Syt5
Delay discounting water rate 24 sec	7.99	1	0	0	0	1e+00	Syt5
Delay discounting water rate 6 sec	7.21	1	0	0	0	1e+00	Trim16
Locomotor activity	4.93	1	0	0	0	1e+00	Trim16
Light reinforcement 1	21.59	1	1	50	0	1e+00	Syt5
Light reinforcement 2	21.57	1	1	50	0	1e+00	Syt5
Reaction time number correct	7.52	1	0	0	0	1e+00	Trim16
Reaction time num false alarms AUC	10.57	1	0	0	0	1e+00	Syt5
Reaction time trials correct on left	7.52	1	0	0	0	1e+00	Trim16
Reaction time trials on left	6.91	1	0	0	0	1e+00	Trim16
Reaction time mean	5.11	1	0	0	0	1e+00	Syt5
Reaction time mean AUC	6.17	1	0	0	0	1e+00	Syt5
Median of all reaction times	6.98	1	0	0	0	1e+00	Syt5
Reaction time omissions	5.26	1	0	0	0	1e+00	Syt5
Reaction time false alarm rate	4.67	1	0	0	0	1e+00	Syt5
Reaction time premature initiation rate	5.84	1	0	0	0	1e+00	Trim16
Reaction time trials completed	6.91	1	0	0	0	1e+00	Trim16
Reaction time trials AUC	5.96	1	0	0	0	1e+00	Trim16
Social response proportion	7.98	1	0	0	0	1e+00	Syt5
Social responses	3.96	1	0	0	0	1e+00	Trim16
Social time	22.02	2	1	50	0	1e+00	Trim16 Syt5
Conditioned locomotion	5.89	1	0	0	0	1e+00	Syt5
Cocaine response after cond. corrected	16.39	2	0	0	0	1e+00	Trim16 Syt5
Cocaine response after cond. not corrected	16.21	2	0	0	0	1e+00	Trim16 Syt5
Saline control response	13.17	1	0	0	0	1e+00	Syt5
Condit. Reinf. lever presses	8.66	2	0	0	0	1e+00	Trim16 Syt5
Pavlov. Cond. change in total contacts	5.83	1	0	0	0	1e+00	Syt5
Conditioned reinforcement - actives	22.28	1	0	0	0	1e+00	Syt5
Conditioned locomotion	15.14	1	0	0	0	1e+00	Syt5
Intermittent access intake day 1-15 change	7.2	1	0	0	0	1e+00	Syt5
Intermittent access intake escalation 2	5.26	1	0	0	0	1e+00	Syt5
Intermitt. access day 1 inactive lever presses	27.85	2	1	50	0	1e+00	Trim16 Syt5
Intermitt. access day 15 inactive lever presses	38.52	1	1	50	0	1e+00	Syt5
Intermitt. access escalation Index	22.41	2	0	0	0	1e+00	Trim16 Syt5
Intermittent access day 1 locomotion	12.82	1	0	0	0	1e+00	Trim16
Intermittent access total locomotion	9.87	1	0	0	0	1e+00	Trim16
Intermittent access standard deviation	9.35	1	0	0	0	1e+00	Syt5
Cocaine induced anxiety	31.69	1	1	50	0	1e+00	Trim16
Post-drug Anxiety	10.38	2	0	0	0	1e+00	Trim16 Syt5
Incentive Sensitization - Responses	6.78	1	0	0	0	1e+00	Syt5
Incentive Sensitization - Breakpoint	8.61	1	0	0	0	1e+00	Syt5
Progressive ratio test 1 inactive lever presses	10.6	1	0	0	0	1e+00	Trim16
Total sessions with >9 infusions	13.7	1	0	0	0	1e+00	Trim16
Short access day 1 total inactive lever presses	19.11	2	1	50	0	1e+00	Trim16 Syt5
Short access day 10 total inactive lever presses	4.84	1	0	0	0	1e+00	Syt5
Short access day 1 total infusions	62.7	1	1	50	0	1e+00	Trim16
Short access total infusions	5.05	1	0	0	0	1e+00	Trim16
Short access day 1 locomotion	33.14	1	1	50	0	1e+00	Trim16
Short access day 10 total locomotion	12.73	2	0	0	0	1e+00	Trim16 Syt5
Short access total locomotion	11.58	2	0	0	0	1e+00	Trim16 Syt5
Compulsive drug intake	11.93	1	0	0	0	1e+00	Trim16
One hour access (shock baseline)	24.39	1	1	50	0	1e+00	Syt5
Number of responses in last shaping day	17.69	2	1	50	0	1e+00	Trim16 Syt5
Context. condit. distance diff. score	4.65	2	0	0	0	1e+00	Trim16 Syt5
Locomotion velocity, session 1	61.51	1	1	50	0	1e+00	Syt5
Locomotion distance, session 1	27.16	2	2	100	0	1e+00	Trim16 Syt5
Locomotion velocity, session 2	20.55	1	0	0	0	1e+00	Syt5
Locomotion distance, session 2	10.55	2	0	0	0	1e+00	Trim16 Syt5
Locomotion distance, session 3	8.71	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 7	5.48	2	0	0	0	1e+00	Trim16 Syt5
Locomotion distance, session 7	10.24	1	0	0	0	1e+00	Syt5
Stereotopy head waving bouts, day 7	25.38	1	1	50	0	1e+00	Trim16
Stereotopy head waving duration, day 7	6.53	1	0	0	0	1e+00	Trim16
Locomotion velocity, session 8	15.73	1	0	0	0	1e+00	Syt5
Locomotion distance, session 8	9.21	1	0	0	0	1e+00	Syt5
Degree of sensitization stereotypy	7.41	1	0	0	0	1e+00	Trim16
Condit. Reinf. active minus inactive responses	5.06	1	0	0	0	1e+00	Trim16
Condit. Reinf. active-inactive response ratio	5.08	1	0	0	0	1e+00	Trim16
Incentive salience index mean	5.91	1	0	0	0	1e+00	Trim16
Time in familiar zone, hab. session 1	9.71	2	0	0	0	1e+00	Trim16 Syt5
Time in novel zone, hab. session 1	5.6	1	0	0	0	1e+00	Trim16
Total zone transitions, hab. session 1	31.46	2	2	100	0	1e+00	Trim16 Syt5
Total locomotion distance, hab. session 1	28.86	2	2	100	0	1e+00	Trim16 Syt5
Locomotion velocity, hab. session 1	21.25	2	1	50	0	1e+00	Trim16 Syt5
Time in familiar zone, hab. session 2	11.34	2	0	0	0	1e+00	Trim16 Syt5
Total zone transitions, hab. session 2	7.86	1	0	0	0	1e+00	Syt5
Total locomotion distance, hab. session 2	11.11	2	0	0	0	1e+00	Trim16 Syt5
Locomotion velocity, hab. session 2	11.81	2	0	0	0	1e+00	Trim16 Syt5
Time in novel zone, NPP test	5.25	1	0	0	0	1e+00	Trim16
Total zone transitions, NPP test	3.88	2	0	0	0	1e+00	Trim16 Syt5
Total locomotion distance, NPP test	4.55	1	0	0	0	1e+00	Trim16
Locomotion velocity, NPP test	3.97	1	0	0	0	1e+00	Trim16
Pavlov. Cond. magazine entry latency	20.7	2	1	50	0	1e+00	Trim16 Syt5
Pavlov. Cond. index score	10.8	1	0	0	0	1e+00	Trim16
Pavlov. Cond. latency score	5.87	1	0	0	0	1e+00	Trim16
Pavlov. Cond. lever contacts	4.84	1	0	0	0	1e+00	Syt5
Pavlov. Cond. magazine entry number	28.02	1	1	50	0	1e+00	Trim16
Pavlov. Cond. intertrial magazine entries	16.95	2	0	0	0	1e+00	Trim16 Syt5
Pavlov. Cond. lever-magazine prob. diff.	10.24	1	0	0	0	1e+00	Trim16
Pavlov. Cond. response bias	10.82	2	0	0	0	1e+00	Trim16 Syt5
Bone: cortical apparent density	18.12	1	0	0	0	1e+00	Trim16
Bone: cortical porosity	21.5	1	0	0	0	1e+00	Trim16
Bone: cortical porosity	17.55	2	1	50	0	1e+00	Trim16 Syt5
Bone: cortical thickness	3.19	1	0	0	0	1e+00	Syt5
Bone: cortical tissue density	19.62	1	0	0	0	1e+00	Trim16
Bone: elastic displacement	7.66	1	0	0	0	1e+00	Syt5
Bone: elastic work	5.84	2	0	0	0	1e+00	Trim16 Syt5
Bone: post-yield work	13.91	2	0	0	0	1e+00	Trim16 Syt5
Bone: stiffness	4.47	1	0	0	0	1e+00	Syt5
Bone: tissue strength	10.29	2	0	0	0	1e+00	Trim16 Syt5
Bone: trabecular tissue density	8.22	1	0	0	0	1e+00	Syt5
Distance traveled before self-admin	57.56	1	1	50	0	1e+00	Syt5
Distance traveled after self-admin	56.65	1	1	50	0	1e+00	Syt5
Delta time in open arm before/after self-admin	18.04	1	0	0	0	1e+00	Syt5
Diff in mean of infusions in LGA sessions	20.43	1	0	0	0	1e+00	Syt5
Extinction: sum of active levers before priming	36.46	1	1	50	0	1e+00	Syt5
Active lever presses in extinction session 6	17.94	1	0	0	0	1e+00	Syt5
Time in closed arm after self-admin	22.26	1	0	0	0	1e+00	Syt5
Time in open arm after self-admin	17.09	1	0	0	0	1e+00	Syt5
Sum of active levers in priming session hrs 5-6	17.22	1	0	0	0	1e+00	Syt5
Time to tail flick, test, before self-admin	57.17	1	1	50	0	1e+00	Syt5
Time to tail flick, test, after self-admin	5.74	1	0	0	0	1e+00	Syt5
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	0	1e+00	Syt5
Delta time to tail flick, test, before/after SA	42.42	1	1	50	0	1e+00	Syt5
Ambulatory time before self-admin	36.65	1	1	50	0	1e+00	Syt5
Ambulatory time after self-admin	61.31	1	1	50	0	1e+00	Syt5
Total heroin consumption	5.77	1	0	0	0	1e+00	Syt5
Delay disc. indifference point, 0s delay	27.96	1	1	50	0	1e+00	Syt5
Delay disc. indifference point, 16s delay	15.37	2	0	0	0	1e+00	Trim16 Syt5
Delay disc. indifference point, 24s delay	9.61	1	0	0	0	1e+00	Syt5
Change in fecal boli incidents, locomotor task	6.15	1	0	0	0	1e+00	Syt5
Bouts of movement, locomotor time 1	56.89	1	1	50	0	1e+00	Syt5
Total resting periods, locomotor time 1	37.3	1	1	50	0	1e+00	Syt5
Vertical activity count, locomotor time 1	24.22	1	0	0	0	1e+00	Syt5
Rest time, locomotor task time 2	9.12	1	0	0	0	1e+00	Syt5
Distance moved, locomotor task time 2	6.59	1	0	0	0	1e+00	Trim16
Vertical activity count, locomotor time 2	5.62	1	0	0	0	1e+00	Syt5
Weight adjusted by age	8.26	1	0	0	0	1e+00	Syt5
Seeking ratio, delayed vs. immediate footshock	29.67	1	1	50	0	1e+00	Syt5
Locomotion in novel chamber	12.66	1	0	0	0	1e+00	Syt5
Progressive ratio	7.56	1	0	0	0	1e+00	Syt5
Food seeking constrained by brief footshock	68.79	2	1	50	0	1e+00	Trim16 Syt5
Seeking ratio, punishment vs. effort	16.51	1	0	0	0	1e+00	Syt5
Run reversals in cocaine runway, females	9.97	2	0	0	0	1e+00	Trim16 Syt5
Run reversals in cocaine runway, males	6.16	1	0	0	0	1e+00	Trim16
Latency to leave start box in cocaine runway	10.73	1	0	0	0	1e+00	Trim16
Latency to leave start box in cocaine runway, F	7.35	1	0	0	0	1e+00	Trim16
Cd content in liver	7.7	1	0	0	0	1e+00	Syt5
Co content in liver	19.37	1	0	0	0	1e+00	Syt5
Cu content in liver	6.23	1	0	0	0	1e+00	Trim16
K content in liver	8.32	1	0	0	0	1e+00	Trim16
Mg content in liver	28.9	1	1	50	0	1e+00	Trim16
Mn content in liver	4.42	1	0	0	0	1e+00	Trim16
Rb content in liver	15.63	2	1	50	0	1e+00	Trim16 Syt5
Se content in liver	19.76	1	0	0	0	1e+00	Trim16
Sr content in liver	66.74	1	1	50	0	1e+00	Syt5
Zn content in liver	12.43	1	0	0	0	1e+00	Syt5

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.13
Adipose	alternative TSS	0	0	0.92
Adipose	gene expression	0	0	1.04
Adipose	isoform ratio	0	0	1.03
Adipose	intron excision ratio	0	0	1.03
Adipose	mRNA stability	0	0	1.05
BLA	alternative polyA	0	0	0.98
BLA	alternative TSS	0	0	1.06
BLA	gene expression	0	0	1.04
BLA	isoform ratio	0	0	1.01
BLA	intron excision ratio	0	0	1.07
BLA	mRNA stability	1	0	1.07
Brain	alternative polyA	0	0	1.1
Brain	alternative TSS	0	0	1.05
Brain	gene expression	0	0	1.04
Brain	isoform ratio	0	0	1.05
Brain	intron excision ratio	0	0	1.06
Brain	mRNA stability	0	0	1.08
Eye	alternative polyA	0	0	1.1
Eye	alternative TSS	0	0	1
Eye	gene expression	0	0	1.05
Eye	isoform ratio	0	0	1.15
Eye	intron excision ratio	0	0	0.99
Eye	mRNA stability	0	0	1.04
IL	alternative polyA	0	0	1.08
IL	alternative TSS	0	0	1.16
IL	gene expression	0	0	1.06
IL	isoform ratio	0	0	1.05
IL	intron excision ratio	0	0	1.08
IL	mRNA stability	0	0	1.04
LHb	alternative polyA	0	0	0.9
LHb	alternative TSS	0	0	1.06
LHb	gene expression	0	0	1.08
LHb	isoform ratio	0	0	1.03
LHb	intron excision ratio	0	0	1.1
LHb	mRNA stability	0	0	1.13
Liver	alternative polyA	0	0	1.14
Liver	alternative TSS	0	0	1.05
Liver	gene expression	0	0	1.09
Liver	isoform ratio	0	0	1.06
Liver	intron excision ratio	0	0	1.05
Liver	mRNA stability	0	0	1.08
NAcc	alternative polyA	0	0	1.09
NAcc	alternative TSS	0	0	1.08
NAcc	gene expression	0	0	1.06
NAcc	isoform ratio	0	0	1.04
NAcc	intron excision ratio	0	0	1.08
NAcc	mRNA stability	0	0	1.13
OFC	alternative polyA	0	0	0.98
OFC	alternative TSS	0	0	1.07
OFC	gene expression	0	0	1.05
OFC	isoform ratio	0	0	0.96
OFC	intron excision ratio	0	0	1.12
OFC	mRNA stability	0	0	1.14
PL	alternative polyA	0	0	1.06
PL	alternative TSS	0	0	1.13
PL	gene expression	1	0	1.06
PL	isoform ratio	0	0	1.04
PL	intron excision ratio	0	0	1.06
PL	mRNA stability	0	0	1.12