Hub : Traits

Baseline Anxiety

Pre-drug hide time

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 1.4e-07 0.041 2.6e-15 -1393 Syt5
2 10 46789397 48185455 1 1 1.9e-08 0.114 1.0e+00 100 Trim16

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 2.6 1 0 0 0 1 Syt5
Epididymis fat weight 2.2 1 0 0 0 1 Syt5
Glucose 12.1 1 0 0 0 1 Syt5
Heart weight 7.8 1 0 0 0 1 Trim16
Right kidney weight 2.6 1 0 0 0 1 Syt5
Length without tail 3.2 1 0 0 0 1 Syt5
Liver weight, left 9.0 2 0 0 0 1 Trim16 Syt5
Liver weight, right 11.2 1 0 0 0 1 Syt5
Intraocular pressure 38.8 1 1 50 0 1 Trim16
Tibialis anterior weight 2.4 1 0 0 0 1 Syt5
Tibia length 7.5 1 0 0 0 1 Syt5
Number of licking bursts 19.2 1 0 0 0 1 Trim16
Food consumed during 24 hour testing period 18.6 1 0 0 0 1 Trim16
Times rat made contact with spout 16.5 1 0 0 0 1 Trim16
Mean num. licks in bursts 46.0 1 1 50 0 1 Trim16
Std. dev. time between licks in bursts 14.1 2 1 50 0 1 Trim16 Syt5
Water consumed over 24 hours 23.8 1 1 50 0 1 Trim16
Indifference point 0 sec 7.1 2 0 0 0 1 Trim16 Syt5
Indifference point function ln k 8.8 1 0 0 0 1 Syt5
Indifference point function log k 8.8 1 0 0 0 1 Syt5
Delay discounting total patch changes 0 sec 7.1 2 0 0 0 1 Trim16 Syt5
Delay discounting total patch changes 18 sec 45.7 1 1 50 0 1 Trim16
Delay discounting total patch changes 24 sec 10.3 1 0 0 0 1 Syt5
Delay discounting total patch changes 6 sec 5.0 1 0 0 0 1 Trim16
Delay discounting time to switch 0 sec 55.9 1 1 50 0 1 Syt5
Delay discounting water rate 0 sec 12.7 2 0 0 0 1 Trim16 Syt5
Delay discounting water rate 12 sec 22.1 1 1 50 0 1 Syt5
Delay discounting water rate 18 sec 19.1 1 0 0 0 1 Syt5
Delay discounting water rate 24 sec 8.0 1 0 0 0 1 Syt5
Delay discounting water rate 6 sec 7.2 1 0 0 0 1 Trim16
Locomotor activity 4.9 1 0 0 0 1 Trim16
Light reinforcement 1 21.6 1 1 50 0 1 Syt5
Light reinforcement 2 21.6 1 1 50 0 1 Syt5
Reaction time number correct 7.5 1 0 0 0 1 Trim16
Reaction time num false alarms AUC 10.6 1 0 0 0 1 Syt5
Reaction time trials correct on left 7.5 1 0 0 0 1 Trim16
Reaction time trials on left 6.9 1 0 0 0 1 Trim16
Reaction time mean 5.1 1 0 0 0 1 Syt5
Reaction time mean AUC 6.2 1 0 0 0 1 Syt5
Median of all reaction times 7.0 1 0 0 0 1 Syt5
Reaction time omissions 5.3 1 0 0 0 1 Syt5
Reaction time false alarm rate 4.7 1 0 0 0 1 Syt5
Reaction time premature initiation rate 5.8 1 0 0 0 1 Trim16
Reaction time trials completed 6.9 1 0 0 0 1 Trim16
Reaction time trials AUC 6.0 1 0 0 0 1 Trim16
Social response proportion 8.0 1 0 0 0 1 Syt5
Social responses 4.0 1 0 0 0 1 Trim16
Social time 22.0 2 1 50 0 1 Trim16 Syt5
Conditioned locomotion 5.9 1 0 0 0 1 Syt5
Cocaine response after cond. corrected 16.4 2 0 0 0 1 Trim16 Syt5
Cocaine response after cond. not corrected 16.2 2 0 0 0 1 Trim16 Syt5
Saline control response 13.2 1 0 0 0 1 Syt5
Condit. Reinf. lever presses 8.7 2 0 0 0 1 Trim16 Syt5
Pavlov. Cond. change in total contacts 5.8 1 0 0 0 1 Syt5
Conditioned reinforcement - actives 22.3 1 0 0 0 1 Syt5
Conditioned locomotion 15.1 1 0 0 0 1 Syt5
Intermittent access intake day 1-15 change 7.2 1 0 0 0 1 Syt5
Intermittent access intake escalation 2 5.3 1 0 0 0 1 Syt5
Intermitt. access day 1 inactive lever presses 27.9 2 1 50 0 1 Trim16 Syt5
Intermitt. access day 15 inactive lever presses 38.5 1 1 50 0 1 Syt5
Intermitt. access escalation Index 22.4 2 0 0 0 1 Trim16 Syt5
Intermittent access day 1 locomotion 12.8 1 0 0 0 1 Trim16
Intermittent access total locomotion 9.9 1 0 0 0 1 Trim16
Intermittent access standard deviation 9.3 1 0 0 0 1 Syt5
Cocaine induced anxiety 31.7 1 1 50 0 1 Trim16
Post-drug Anxiety 10.4 2 0 0 0 1 Trim16 Syt5
Incentive Sensitization - Responses 6.8 1 0 0 0 1 Syt5
Incentive Sensitization - Breakpoint 8.6 1 0 0 0 1 Syt5
Progressive ratio test 1 inactive lever presses 10.6 1 0 0 0 1 Trim16
Total sessions with >9 infusions 13.7 1 0 0 0 1 Trim16
Short access day 1 total inactive lever presses 19.1 2 1 50 0 1 Trim16 Syt5
Short access day 10 total inactive lever presses 4.8 1 0 0 0 1 Syt5
Short access day 1 total infusions 62.7 1 1 50 0 1 Trim16
Short access total infusions 5.0 1 0 0 0 1 Trim16
Short access day 1 locomotion 33.1 1 1 50 0 1 Trim16
Short access day 10 total locomotion 12.7 2 0 0 0 1 Trim16 Syt5
Short access total locomotion 11.6 2 0 0 0 1 Trim16 Syt5
Compulsive drug intake 11.9 1 0 0 0 1 Trim16
One hour access (shock baseline) 24.4 1 1 50 0 1 Syt5
Number of responses in last shaping day 17.7 2 1 50 0 1 Trim16 Syt5
Context. condit. distance diff. score 4.7 2 0 0 0 1 Trim16 Syt5
Locomotion velocity, session 1 61.5 1 1 50 0 1 Syt5
Locomotion distance, session 1 27.2 2 2 100 0 1 Trim16 Syt5
Locomotion velocity, session 2 20.6 1 0 0 0 1 Syt5
Locomotion distance, session 2 10.6 2 0 0 0 1 Trim16 Syt5
Locomotion distance, session 3 8.7 1 0 0 0 1 Syt5
Locomotion velocity, session 7 5.5 2 0 0 0 1 Trim16 Syt5
Locomotion distance, session 7 10.2 1 0 0 0 1 Syt5
Stereotopy head waving bouts, day 7 25.4 1 1 50 0 1 Trim16
Stereotopy head waving duration, day 7 6.5 1 0 0 0 1 Trim16
Locomotion velocity, session 8 15.7 1 0 0 0 1 Syt5
Locomotion distance, session 8 9.2 1 0 0 0 1 Syt5
Degree of sensitization stereotypy 7.4 1 0 0 0 1 Trim16
Condit. Reinf. active minus inactive responses 5.1 1 0 0 0 1 Trim16
Condit. Reinf. active-inactive response ratio 5.1 1 0 0 0 1 Trim16
Incentive salience index mean 5.9 1 0 0 0 1 Trim16
Time in familiar zone, hab. session 1 9.7 2 0 0 0 1 Trim16 Syt5
Time in novel zone, hab. session 1 5.6 1 0 0 0 1 Trim16
Total zone transitions, hab. session 1 31.5 2 2 100 0 1 Trim16 Syt5
Total locomotion distance, hab. session 1 28.9 2 2 100 0 1 Trim16 Syt5
Locomotion velocity, hab. session 1 21.2 2 1 50 0 1 Trim16 Syt5
Time in familiar zone, hab. session 2 11.3 2 0 0 0 1 Trim16 Syt5
Total zone transitions, hab. session 2 7.9 1 0 0 0 1 Syt5
Total locomotion distance, hab. session 2 11.1 2 0 0 0 1 Trim16 Syt5
Locomotion velocity, hab. session 2 11.8 2 0 0 0 1 Trim16 Syt5
Time in novel zone, NPP test 5.2 1 0 0 0 1 Trim16
Total zone transitions, NPP test 3.9 2 0 0 0 1 Trim16 Syt5
Total locomotion distance, NPP test 4.5 1 0 0 0 1 Trim16
Locomotion velocity, NPP test 4.0 1 0 0 0 1 Trim16
Pavlov. Cond. magazine entry latency 20.7 2 1 50 0 1 Trim16 Syt5
Pavlov. Cond. index score 10.8 1 0 0 0 1 Trim16
Pavlov. Cond. latency score 5.9 1 0 0 0 1 Trim16
Pavlov. Cond. lever contacts 4.8 1 0 0 0 1 Syt5
Pavlov. Cond. magazine entry number 28.0 1 1 50 0 1 Trim16
Pavlov. Cond. intertrial magazine entries 16.9 2 0 0 0 1 Trim16 Syt5
Pavlov. Cond. lever-magazine prob. diff. 10.2 1 0 0 0 1 Trim16
Pavlov. Cond. response bias 10.8 2 0 0 0 1 Trim16 Syt5
Bone: cortical apparent density 18.1 1 0 0 0 1 Trim16
Bone: cortical porosity 21.5 1 0 0 0 1 Trim16
Bone: cortical porosity 17.6 2 1 50 0 1 Trim16 Syt5
Bone: cortical thickness 3.2 1 0 0 0 1 Syt5
Bone: cortical tissue density 19.6 1 0 0 0 1 Trim16
Bone: elastic displacement 7.7 1 0 0 0 1 Syt5
Bone: elastic work 5.8 2 0 0 0 1 Trim16 Syt5
Bone: post-yield work 13.9 2 0 0 0 1 Trim16 Syt5
Bone: stiffness 4.5 1 0 0 0 1 Syt5
Bone: tissue strength 10.3 2 0 0 0 1 Trim16 Syt5
Bone: trabecular tissue density 8.2 1 0 0 0 1 Syt5
Distance traveled before self-admin 57.6 1 1 50 0 1 Syt5
Distance traveled after self-admin 56.6 1 1 50 0 1 Syt5
Delta time in open arm before/after self-admin 18.0 1 0 0 0 1 Syt5
Diff in mean of infusions in LGA sessions 20.4 1 0 0 0 1 Syt5
Extinction: sum of active levers before priming 36.5 1 1 50 0 1 Syt5
Active lever presses in extinction session 6 17.9 1 0 0 0 1 Syt5
Time in closed arm after self-admin 22.3 1 0 0 0 1 Syt5
Time in open arm after self-admin 17.1 1 0 0 0 1 Syt5
Sum of active levers in priming session hrs 5-6 17.2 1 0 0 0 1 Syt5
Time to tail flick, test, before self-admin 57.2 1 1 50 0 1 Syt5
Time to tail flick, test, after self-admin 5.7 1 0 0 0 1 Syt5
Delta time to tail flick, vehicle, before/after SA 8.6 1 0 0 0 1 Syt5
Delta time to tail flick, test, before/after SA 42.4 1 1 50 0 1 Syt5
Ambulatory time before self-admin 36.6 1 1 50 0 1 Syt5
Ambulatory time after self-admin 61.3 1 1 50 0 1 Syt5
Total heroin consumption 5.8 1 0 0 0 1 Syt5
Delay disc. indifference point, 0s delay 28.0 1 1 50 0 1 Syt5
Delay disc. indifference point, 16s delay 15.4 2 0 0 0 1 Trim16 Syt5
Delay disc. indifference point, 24s delay 9.6 1 0 0 0 1 Syt5
Change in fecal boli incidents, locomotor task 6.2 1 0 0 0 1 Syt5
Bouts of movement, locomotor time 1 56.9 1 1 50 0 1 Syt5
Total resting periods, locomotor time 1 37.3 1 1 50 0 1 Syt5
Vertical activity count, locomotor time 1 24.2 1 0 0 0 1 Syt5
Rest time, locomotor task time 2 9.1 1 0 0 0 1 Syt5
Distance moved, locomotor task time 2 6.6 1 0 0 0 1 Trim16
Vertical activity count, locomotor time 2 5.6 1 0 0 0 1 Syt5
Weight adjusted by age 8.3 1 0 0 0 1 Syt5
Seeking ratio, delayed vs. immediate footshock 29.7 1 1 50 0 1 Syt5
Locomotion in novel chamber 12.7 1 0 0 0 1 Syt5
Progressive ratio 7.6 1 0 0 0 1 Syt5
Food seeking constrained by brief footshock 68.8 2 1 50 0 1 Trim16 Syt5
Seeking ratio, punishment vs. effort 16.5 1 0 0 0 1 Syt5
Run reversals in cocaine runway, females 10.0 2 0 0 0 1 Trim16 Syt5
Run reversals in cocaine runway, males 6.2 1 0 0 0 1 Trim16
Latency to leave start box in cocaine runway 10.7 1 0 0 0 1 Trim16
Latency to leave start box in cocaine runway, F 7.3 1 0 0 0 1 Trim16
Cd content in liver 7.7 1 0 0 0 1 Syt5
Co content in liver 19.4 1 0 0 0 1 Syt5
Cu content in liver 6.2 1 0 0 0 1 Trim16
K content in liver 8.3 1 0 0 0 1 Trim16
Mg content in liver 28.9 1 1 50 0 1 Trim16
Mn content in liver 4.4 1 0 0 0 1 Trim16
Rb content in liver 15.6 2 1 50 0 1 Trim16 Syt5
Se content in liver 19.8 1 0 0 0 1 Trim16
Sr content in liver 66.7 1 1 50 0 1 Syt5
Zn content in liver 12.4 1 0 0 0 1 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.13
Adipose alternative TSS 0 0.000 0.92
Adipose gene expression 0 0.000 1.04
Adipose isoform ratio 0 0.000 1.03
Adipose intron excision ratio 0 0.000 1.03
Adipose mRNA stability 0 0.000 1.05
BLA alternative polyA 0 0.000 0.98
BLA alternative TSS 0 0.000 1.06
BLA gene expression 0 0.000 1.04
BLA isoform ratio 0 0.000 1.01
BLA intron excision ratio 0 0.000 1.07
BLA mRNA stability 1 0.050 1.07
Brain alternative polyA 0 0.000 1.10
Brain alternative TSS 0 0.000 1.05
Brain gene expression 0 0.000 1.04
Brain isoform ratio 0 0.000 1.05
Brain intron excision ratio 0 0.000 1.06
Brain mRNA stability 0 0.000 1.08
Eye alternative polyA 0 0.000 1.10
Eye alternative TSS 0 0.000 1.00
Eye gene expression 0 0.000 1.05
Eye isoform ratio 0 0.000 1.15
Eye intron excision ratio 0 0.000 0.99
Eye mRNA stability 0 0.000 1.04
IL alternative polyA 0 0.000 1.08
IL alternative TSS 0 0.000 1.16
IL gene expression 0 0.000 1.06
IL isoform ratio 0 0.000 1.05
IL intron excision ratio 0 0.000 1.08
IL mRNA stability 0 0.000 1.04
LHb alternative polyA 0 0.000 0.90
LHb alternative TSS 0 0.000 1.06
LHb gene expression 0 0.000 1.08
LHb isoform ratio 0 0.000 1.03
LHb intron excision ratio 0 0.000 1.10
LHb mRNA stability 0 0.000 1.13
Liver alternative polyA 0 0.000 1.14
Liver alternative TSS 0 0.000 1.05
Liver gene expression 0 0.000 1.09
Liver isoform ratio 0 0.000 1.06
Liver intron excision ratio 0 0.000 1.05
Liver mRNA stability 0 0.000 1.08
NAcc alternative polyA 0 0.000 1.09
NAcc alternative TSS 0 0.000 1.08
NAcc gene expression 0 0.000 1.06
NAcc isoform ratio 0 0.000 1.04
NAcc intron excision ratio 0 0.000 1.08
NAcc mRNA stability 0 0.000 1.13
OFC alternative polyA 0 0.000 0.98
OFC alternative TSS 0 0.000 1.07
OFC gene expression 0 0.000 1.05
OFC isoform ratio 0 0.000 0.96
OFC intron excision ratio 0 0.000 1.12
OFC mRNA stability 0 0.000 1.14
PL alternative polyA 0 0.000 1.06
PL alternative TSS 0 0.000 1.13
PL gene expression 1 0.014 1.06
PL isoform ratio 0 0.000 1.04
PL intron excision ratio 0 0.000 1.06
PL mRNA stability 0 0.000 1.12

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.