Hub : Traits

Baseline Anxiety

Pre-drug hide time

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	93051299	94447794	1	1	1.82e-08	2.57e-03	8.13e-01	Zfp715
2	chr9	75969545	77365260	1	1	3.61e-93	1.46e-01	1.00e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	50	0	1e+00	Zfand2b
BMI without tail	53.65	1	1	50	0	1e+00	Zfand2b
Epididymis fat weight	111.28	1	1	50	0	1e+00	Zfand2b
Heart weight	71.7	1	1	50	0	1e+00	Zfand2b
Left kidney weight	15.14	2	1	50	0	1e+00	Zfand2b Zfp715
Right kidney weight	54.05	1	1	50	0	1e+00	Zfand2b
Tail length	125.62	1	1	50	0	1e+00	Zfand2b
Length with tail	3.12	2	0	0	0	1e+00	Zfand2b Zfp715
Length without tail	40.54	2	1	50	0	1e+00	Zfand2b Zfp715
Liver weight, right	17.57	1	1	50	0	1e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1e+00	Zfand2b
Retroperitoneal fat weight	4.62	2	0	0	0	1e+00	Zfand2b Zfp715
Intraocular pressure	51.69	1	1	50	0	1e+00	Zfand2b
Tibialis anterior weight	1.65	1	0	0	0	1e+00	Zfand2b
Number of licking bursts	32.5	1	1	50	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	11.05	2	0	0	0	1e+00	Zfand2b Zfp715
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	50	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	11.8	1	0	0	0	1e+00	Zfand2b
Patch foraging indifference point AUC	24.2	1	1	50	0	1e+00	Zfand2b
Indifference point function ln k	54.42	1	1	50	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	23.48	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 12 sec	4.29	1	0	0	0	1e+00	Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 6 sec	24.67	1	1	50	0	1e+00	Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	50	0	1e+00	Zfand2b
Locomotor activity	12.38	1	0	0	0	1e+00	Zfand2b
Locomotor testing distance	47.2	1	1	50	0	1e+00	Zfand2b
Locomotor testing rearing	99.51	1	1	50	0	1e+00	Zfand2b
Light reinforcement 1	19.25	1	1	50	0	1e+00	Zfand2b
Light reinforcement 2	6.57	1	0	0	0	1e+00	Zfand2b
Reaction time number correct	114.79	1	1	50	0	1e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	50	0	1e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	50	0	1e+00	Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	50	0	1e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	50	0	1e+00	Zfand2b
Reaction time trials on left	106.69	1	1	50	0	1e+00	Zfand2b
Reaction time mean	36.11	1	1	50	0	1e+00	Zfand2b
Reaction time mean AUC	33.75	1	1	50	0	1e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1e+00	Zfand2b
Reaction time omissions	46.56	1	1	50	0	1e+00	Zfand2b
Reaction time false alarm rate	3.92	1	0	0	0	1e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	50	0	1e+00	Zfand2b
Std. dev. reaction times	72.92	1	1	50	0	1e+00	Zfand2b
Reaction time trials completed	106.69	1	1	50	0	1e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	50	0	1e+00	Zfand2b
Social response proportion	8.13	2	0	0	0	1e+00	Zfand2b Zfp715
Cocaine response after cond. corrected	12.71	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	50	0	1e+00	Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	50	0	1e+00	Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1e+00	Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	50	0	1e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	50	0	1e+00	Zfand2b
Intermitt. access day 1 inactive lever presses	169.63	1	1	50	0	1e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	294.26	1	1	50	0	1e+00	Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	50	0	1e+00	Zfand2b
Intermittent access day 15 total infusions	19.99	2	1	50	0	1e+00	Zfand2b Zfp715
Intermittent access terminal intake (last 3 days)	25.82	1	1	50	0	1e+00	Zfand2b
Intermittent access day 1 locomotion	26.47	1	1	50	0	1e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	50	0	1e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1e+00	Zfand2b
Intermittent access standard deviation	226.83	2	1	50	0	1e+00	Zfand2b Zfp715
Cocaine induced anxiety	70.55	2	1	50	0	1e+00	Zfand2b Zfp715
Incentive Sensitization - Responses	309.83	1	1	50	0	1e+00	Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	50	0	1e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	50	0	1e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1e+00	Zfand2b
Progressive ratio test 2 active lever presses	109.22	1	1	50	0	1e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	50	0	1e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	50	0	1e+00	Zfand2b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	50	0	1e+00	Zfand2b
Short access day 1 locomotion	129.19	1	1	50	0	1e+00	Zfand2b
Short access day 10 total locomotion	222.66	2	1	50	0	1e+00	Zfand2b Zfp715
Short access total locomotion	209.96	1	1	50	0	1e+00	Zfand2b
Compulsive drug intake	38.45	2	1	50	0	1e+00	Zfand2b Zfp715
One hour access (0.3 mA shock)	14.02	2	0	0	0	1e+00	Zfand2b Zfp715
One hour access (shock baseline)	7.33	1	0	0	0	1e+00	Zfp715
Number of responses in last shaping day	43.49	2	1	50	0	1e+00	Zfand2b Zfp715
Context. condit. distance diff. score	4.96	1	0	0	0	1e+00	Zfp715
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Locomotion velocity, session 8	4.59	1	0	0	0	1e+00	Zfp715
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Bone: trabecular tissue density	6.64	1	0	0	0	1e+00	Zfp715
Distance traveled before self-admin	5.58	1	0	0	0	1e+00	Zfand2b
Distance traveled after self-admin	8.08	2	0	0	0	1e+00	Zfand2b Zfp715
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1e+00	Zfand2b
Delta ambulatory time before/after self-admin	6.19	1	0	0	0	1e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	50	0	1e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.97	1	0	0	0	1e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	75.62	1	1	50	0	1e+00	Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1e+00	Zfand2b
Time to tail flick, test, after self-admin	5.63	1	0	0	0	1e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	50	0	1e+00	Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1e+00	Zfand2b
Ambulatory time after self-admin	4.73	1	0	0	0	1e+00	Zfand2b
Area under the delay curve	31.15	1	1	50	0	1e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	50	0	1e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	50	0	1e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	50	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	50	0	1e+00	Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1e+00	Zfand2b
Rest time, locomotor task time 1	11.47	1	0	0	0	1e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	50	0	1e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	50	0	1e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	50	0	1e+00	Zfand2b
Distance moved, locomotor task time 2	44.17	2	1	50	0	1e+00	Zfand2b Zfp715
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1e+00	Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.74	1	0	0	0	1e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1e+00	Zfand2b
Seeking ratio, punishment vs. effort	4.29	1	0	0	0	1e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	50	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	50	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	50	0	1e+00	Zfand2b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.07
Adipose	alternative TSS	0	0	1.05
Adipose	gene expression	1	0	1.05
Adipose	isoform ratio	0	0	1.03
Adipose	intron excision ratio	0	0	1.02
Adipose	mRNA stability	0	0	1.04
BLA	alternative polyA	0	0	1.04
BLA	alternative TSS	0	0	1.09
BLA	gene expression	0	0	1.04
BLA	isoform ratio	0	0	1.05
BLA	intron excision ratio	0	0	1.03
BLA	mRNA stability	0	0	1.08
Brain	alternative polyA	0	0	1.05
Brain	alternative TSS	0	0	1.08
Brain	gene expression	0	0	1.05
Brain	isoform ratio	0	0	1.08
Brain	intron excision ratio	0	0	1.08
Brain	mRNA stability	0	0	1.08
Eye	alternative polyA	0	0	1.43
Eye	alternative TSS	0	0	0.99
Eye	gene expression	0	0	1.04
Eye	isoform ratio	0	0	1.11
Eye	intron excision ratio	0	0	1.06
Eye	mRNA stability	0	0	1.08
IL	alternative polyA	0	0	1.04
IL	alternative TSS	0	0	0.9
IL	gene expression	0	0	1.06
IL	isoform ratio	0	0	1.08
IL	intron excision ratio	0	0	1.02
IL	mRNA stability	0	0	1.07
LHb	alternative polyA	0	0	1.19
LHb	alternative TSS	0	0	1.05
LHb	gene expression	0	0	1.05
LHb	isoform ratio	0	0	1.12
LHb	intron excision ratio	0	0	1.08
LHb	mRNA stability	0	0	1.11
Liver	alternative polyA	0	0	1.14
Liver	alternative TSS	0	0	1.02
Liver	gene expression	0	0	1.07
Liver	isoform ratio	0	0	1.09
Liver	intron excision ratio	0	0	1.03
Liver	mRNA stability	0	0	1.03
NAcc	alternative polyA	0	0	1.05
NAcc	alternative TSS	0	0	1.08
NAcc	gene expression	0	0	1.07
NAcc	isoform ratio	0	0	1.09
NAcc	intron excision ratio	0	0	1.05
NAcc	mRNA stability	0	0	1.07
OFC	alternative polyA	0	0	1.03
OFC	alternative TSS	0	0	0.92
OFC	gene expression	0	0	1.04
OFC	isoform ratio	0	0	1.1
OFC	intron excision ratio	0	0	1.06
OFC	mRNA stability	0	0	1.12
PL	alternative polyA	0	0	1.11
PL	alternative TSS	0	0	1.11
PL	gene expression	0	0	1.06
PL	isoform ratio	0	0	1.09
PL	intron excision ratio	1	0	1.14
PL	mRNA stability	0	0	1.08
pVTA	alternative polyA	0	0	1.12
pVTA	alternative TSS	0	0	1.16
pVTA	gene expression	0	0	1.11
pVTA	isoform ratio	0	0	1.15
pVTA	intron excision ratio	0	0	1.1
pVTA	mRNA stability	0	0	1.12
RMTg	alternative polyA	0	0	0.9
RMTg	alternative TSS	0	0	0.92
RMTg	gene expression	0	0	1.07
RMTg	isoform ratio	0	0	1
RMTg	intron excision ratio	0	0	1.1
RMTg	mRNA stability	0	0	1.06