Arhgef17

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr1_155252141_155286568	0.13	0.08	1.4e-04	0.04	0.07	0.05	0.05	2.1e-03	1.3e-04	1.1e-03	1.1e-03
2	BLA	intron excision ratio	chr1_155252141_155256252	0.12	0.07	1.2e-04	0.07	0.05	0.04	0.05	1.8e-04	1.0e-03	2.4e-03	1.0e-03
3	PL	mRNA stability	Arhgef17	0.03	0.03	1.9e-03	0.02	0.03	0.01	0.02	1.1e-03	8.1e-04	1.3e-02	1.7e-03
4	Adipose	mRNA stability	Arhgef17	0.09	0.05	6.0e-08	0.03	0.05	0.04	0.04	2.7e-04	5.2e-06	9.0e-06	1.3e-05
5	Brain	gene expression	Arhgef17	0.2	0.09	0.0e+00	0.16	0.2	0.19	0.19	1.2e-14	2.0e-18	2.1e-17	4.0e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.6	-0.6	-0.5	-0.1	0.7	-0.8
Area under the delay curve	0.1	0.1	0.2	-0.3	-0.2	0.5	0.0	0.3
BMI with tail	0.0	0.1	0.1	-0.4	-0.1	0.3	0.1	0.3
BMI without tail	1.2	2.4	5.0	1.1	1.2	0.6	-2.1	2.2
Body weight	0.9	3.8	9.0	1.3	1.0	1.1	-2.5	3.0
Weight adjusted by age	0.8	0.9	1.5	0.9	0.9	-0.0	-1.2	1.1
Bone surface	0.6	1.0	1.5	1.2	1.2	-1.1	-0.9	-0.1
Bone volume	0.3	0.6	0.9	0.9	0.9	-0.8	-0.6	-0.1
Breakpoint value in progressive ratio session	0.5	0.5	0.8	-0.7	-0.8	0.1	0.9	-0.8
Number of licking bursts	3.6	4.3	7.9	-2.3	-2.4	2.8	1.2	1.0
Context. condit. distance diff. score	1.8	2.2	4.2	1.6	1.7	-2.0	-0.6	-1.0
Locomotion velocity, session 1	0.7	0.8	1.5	-0.9	-0.6	-0.2	1.2	-1.2
Locomotion distance, session 1	0.6	0.8	1.9	0.6	0.7	-1.4	-0.1	-1.0
Locomotion velocity, session 2	0.0	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.0
Locomotion distance, session 2	0.2	0.3	0.7	0.6	0.5	-0.8	-0.3	-0.4
Locomotion velocity, session 3	0.5	0.6	1.2	0.5	0.6	-1.1	0.1	-1.0
Locomotion distance, session 3	1.1	1.2	2.6	0.6	0.9	-1.6	0.2	-1.4
Stereotopy head waving bouts, day 3	0.4	0.5	1.1	-0.1	-0.3	1.0	-0.4	1.0
Stereotopy head waving duration, day 3	0.1	0.1	0.1	0.2	0.1	-0.4	0.1	-0.4
Locomotion velocity, session 7	0.3	0.3	0.5	-0.7	-0.4	0.2	0.7	-0.5
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	-0.2	0.5	0.2	0.3
Stereotopy head waving bouts, day 7	1.7	1.9	4.0	1.4	1.5	-2.0	-0.7	-1.0
Stereotopy head waving duration, day 7	2.1	2.5	4.6	1.7	1.8	-2.1	-1.1	-0.7
Locomotion velocity, session 8	0.6	0.7	1.1	1.0	1.0	-1.0	-0.6	-0.4
Locomotion distance, session 8	1.7	2.5	4.1	1.9	1.8	-2.0	-1.0	-0.6
Degree of sensitization distance	1.8	1.8	4.9	0.2	-0.2	1.6	-1.1	2.2
Degree of sensitization stereotypy	3.8	4.2	8.2	2.2	2.3	-2.9	-1.2	-1.2
Conditioned locomotion	0.1	0.1	0.2	0.0	-0.4	0.2	0.4	-0.1
Cocaine response after cond. corrected	1.3	1.5	3.2	-1.2	-1.3	1.8	0.3	1.0
Cocaine response after cond. not corrected	0.4	0.4	0.8	-0.9	-0.7	0.8	0.4	0.2
Cocaine response before conditioning	1.5	1.9	4.5	0.7	1.2	-2.1	0.1	-1.7
Saline control response	2.3	3.0	4.8	2.2	2.0	-1.1	-2.0	0.9
Bone: connectivity density	0.5	0.7	1.9	-0.6	-0.2	-0.8	0.9	-1.4
Bone: cortical apparent density	1.4	1.9	4.4	-1.1	-1.4	2.1	0.3	1.3
Bone: cortical area	0.6	0.9	1.4	1.2	0.9	-0.2	-1.2	0.9
Bone: cortical porosity	0.8	0.9	2.1	0.6	0.8	-1.4	0.2	-1.2
Bone: cortical porosity	0.7	0.7	1.7	0.5	0.6	-1.3	0.2	-1.1
Bone: cortical thickness	0.1	0.1	0.3	-0.4	-0.5	0.4	0.3	-0.0
Bone: cortical thickness	0.1	0.1	0.2	0.4	0.2	-0.4	0.0	-0.3
Bone: cortical tissue density	1.4	1.8	4.3	-1.1	-1.4	2.1	0.3	1.3
Condit. Reinf. active minus inactive responses	0.6	0.6	1.1	0.8	0.7	0.1	-1.0	1.0
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.8	1.1	1.1	-0.2	-1.4	1.1
Condit. Reinf. active responses	0.2	0.3	0.6	0.5	0.3	0.3	-0.6	0.8
Condit. Reinf. inactive responses	0.0	0.1	0.1	-0.2	-0.3	0.2	0.3	-0.1
Incentive salience index mean	0.5	0.6	1.0	0.8	0.7	-0.0	-1.0	0.8
Condit. Reinf. lever presses	0.1	0.1	0.2	0.3	0.3	-0.2	-0.4	0.2
Condit. Reinf. active minus inactive responses	6.9	8.6	13.1	3.6	3.5	-2.3	-3.3	1.1
Condit. Reinf. active-inactive response ratio	1.5	1.5	2.4	1.5	1.5	-1.3	-1.2	0.1
Condit. Reinf. active responses	9.3	13.0	20.0	4.5	4.3	-2.5	-4.1	1.7
Condit. Reinf. inactive responses	5.9	7.2	11.2	3.3	3.1	-1.6	-3.2	1.6
Condit. Reinf. lever presses	15.1	20.4	31.6	5.5	5.6	-4.4	-4.5	0.7
Condit. Reinf. lever reinforcers received	10.1	14.2	21.8	4.7	4.5	-2.9	-4.2	1.5
Conditioned reinforcement - actives	1.9	1.9	4.4	1.2	1.5	-2.1	-0.3	-1.1
Conditioned reinforcement - inactives	0.1	0.1	0.4	0.0	-0.1	0.5	-0.2	0.6
Conditioned locomotion	1.9	2.3	5.5	1.2	1.5	-2.3	-0.1	-1.6
Patch foraging indifference point 0 sec	2.6	4.2	6.4	2.4	2.4	-2.5	-1.5	-0.4
Patch foraging indifference point AUC	0.6	0.7	1.7	0.5	0.3	0.6	-1.0	1.3
Delay disc. indifference point, 0s delay	0.7	0.7	1.2	1.1	1.0	-0.6	-0.9	0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.3	-0.3	0.2	0.5	-0.1
Delay disc. indifference point, 2s delay	0.8	0.9	1.6	1.0	0.9	-0.2	-1.3	0.9
Delay disc. indifference point, 24s delay	0.9	0.9	1.4	-1.0	-1.2	1.1	0.9	0.1
Delay disc. indifference point, 4s delay	1.2	1.3	2.4	1.2	1.0	0.0	-1.5	1.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.1	0.0	0.1	0.0
Indifference point function ln k	1.1	1.6	3.4	0.5	0.7	-1.9	0.6	-1.8
Indifference point function log k	1.1	1.6	3.4	0.5	0.7	-1.9	0.6	-1.8
Patch foraging total patch changes 0 sec	2.0	3.3	4.9	2.2	2.2	-2.2	-1.4	-0.2
Patch foraging total patch changes 12 sec	1.5	2.0	3.2	1.7	1.3	-0.4	-1.8	1.4
Patch foraging total patch changes 18 sec	1.5	1.9	2.9	1.7	1.7	-1.4	-1.4	0.3
Patch foraging total patch changes 24 sec	1.5	1.8	3.0	1.6	1.4	-0.5	-1.7	1.3
Patch foraging total patch changes 6 sec	0.3	0.5	0.8	0.9	0.8	-0.9	-0.5	-0.1
Patch foraging time to switch 0 sec	2.9	4.4	6.7	-2.6	-2.6	2.1	2.1	-0.3
Patch foraging water rate 0 sec	2.2	3.5	5.1	2.2	2.2	-2.3	-1.4	-0.3
Patch foraging water rate 12 sec	1.6	2.4	4.8	1.6	1.8	-2.2	-0.7	-0.8
Patch foraging water rate 18 sec	1.6	2.1	3.4	1.7	1.9	-1.2	-1.6	0.4
Patch foraging water rate 24 sec	0.9	1.2	3.0	0.7	0.8	-1.7	0.3	-1.4
Patch foraging water rate 6 sec	0.9	1.3	2.8	1.1	1.2	-1.7	-0.4	-0.8
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	2.5	-1.6	-1.4	0.5	1.5	-0.9
Distance traveled before self-admin	1.2	1.2	2.1	-1.3	-1.3	1.4	0.8	0.4
Distance traveled after self-admin	0.7	0.8	1.4	-0.6	-0.9	-0.1	1.1	-1.2
Extensor digitorum longus weight	0.2	0.8	2.3	-0.1	-0.0	1.1	-0.8	1.5
Bone: elastic displacement	2.4	2.7	4.2	-2.1	-2.0	1.1	1.9	-0.9
Bone: elastic work	2.7	3.4	5.5	-2.3	-2.0	0.8	2.2	-1.5
Bone: endosteal estimation	1.5	3.3	5.4	2.1	2.0	-0.7	-2.3	1.5
Bone: endosteal perimeter	1.9	3.9	5.9	2.3	2.3	-1.1	-2.4	1.3
Epididymis fat weight	0.7	1.6	3.7	-0.5	-0.5	1.8	-0.6	1.9
Delta time in closed arm before/after self-admin	2.3	2.2	5.3	-0.5	-0.6	2.2	-0.7	2.3
Delta time in open arm before/after self-admin	3.1	3.0	4.5	2.1	2.1	-2.0	-1.5	-0.1
Diff in mean of infusions in LGA sessions	2.1	2.3	4.7	-1.6	-1.8	2.2	0.7	0.8
Delay discount exponential model param	0.1	0.1	0.3	0.3	0.2	-0.5	-0.1	-0.3
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.3	-0.2	0.3	0.1	0.1
Active lever presses in extinction session 6	2.1	2.0	4.6	0.7	0.7	-2.1	0.6	-2.1
Bone: final force	0.1	0.1	0.2	0.3	-0.1	0.4	-0.1	0.5
Bone: final moment	0.1	0.1	0.3	0.5	0.2	0.1	-0.4	0.5
Food consumed during 24 hour testing period	2.7	3.2	6.5	1.8	2.0	-2.5	-0.9	-1.1
Glucose	0.1	0.1	0.4	-0.2	-0.0	-0.4	0.3	-0.6
Heart weight	0.9	1.2	2.0	1.2	1.4	-1.4	-0.7	-0.4
Delay discount hyperbolic model param	0.1	0.1	0.3	0.1	-0.0	-0.4	0.2	-0.5
Intermittent access intake day 1-15 change	0.4	0.4	0.9	0.6	0.7	-0.9	-0.4	-0.4
Intermittent access intake escalation	0.5	0.5	1.1	0.6	0.8	-1.0	-0.4	-0.5
Intermittent access intake escalation 2	0.2	0.2	0.4	0.4	0.5	-0.1	-0.6	0.5
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.5	-0.2	-0.3	0.7	-0.1	0.7
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	0.3	0.2	-0.6	0.2	-0.7
Intermitt. access escalation Index	0.2	0.2	0.4	0.6	0.6	-0.5	-0.3	0.0
Intermittent access day 1 total infusions	1.2	1.4	2.2	1.5	1.5	-1.2	-1.0	0.0
Intermittent access day 15 total infusions	1.4	1.6	2.6	1.5	1.5	-1.6	-0.9	-0.4
Intermittent access terminal intake (last 3 days)	1.3	1.4	2.2	1.5	1.4	-1.3	-1.0	-0.1
Intermittent access total infusions	1.2	1.3	2.0	1.4	1.4	-1.2	-1.0	-0.0
Intermittent access day 1 locomotion	0.1	0.2	0.3	0.3	0.2	-0.6	0.1	-0.6
Intermittent access day 15 total locomotion	0.9	1.0	2.2	0.9	1.1	-1.5	-0.3	-0.8
Intermittent access total locomotion	0.5	0.6	1.0	0.9	0.9	-1.0	-0.5	-0.3
Intermittent access standard deviation	0.0	0.0	0.1	0.2	0.1	-0.0	-0.3	0.3
Left kidney weight	1.2	3.4	5.9	1.8	1.8	-0.1	-2.4	2.1
Right kidney weight	0.8	2.2	3.6	1.4	1.4	0.1	-1.9	1.8
Cocaine induced anxiety	2.0	2.3	3.8	-1.7	-1.9	1.7	1.4	0.1
Post-drug Anxiety	0.7	0.8	2.0	-0.6	-0.9	1.4	0.1	0.9
Baseline Anxiety	1.6	1.7	2.6	1.6	1.6	-0.9	-1.5	0.6
Tail length	4.2	12.8	23.7	3.6	3.0	0.4	-4.9	4.3
Length with tail	2.4	9.0	16.3	2.8	2.0	1.0	-4.0	4.0
Length without tail	0.1	0.2	0.4	-0.3	-0.7	0.7	0.3	0.2
Times rat made contact with spout	0.4	0.5	1.2	-0.2	-0.3	1.0	-0.5	1.1
Lifetime Intake	1.5	1.7	2.7	1.6	1.7	-1.5	-1.1	-0.1
Liver weight, left	0.9	1.5	3.9	-0.2	-0.4	1.6	-0.7	2.0
Liver weight, right	2.1	3.5	9.1	-0.2	-0.6	2.6	-1.2	3.0
Locomotor activity	0.2	0.4	0.8	0.9	0.6	-0.8	-0.4	-0.2
Locomotor testing distance	1.4	2.3	4.1	2.0	1.7	-1.4	-1.6	0.4
Locomotor testing rearing	1.0	1.6	2.8	1.4	1.1	-0.0	-1.7	1.4
Locomotion in novel chamber	0.8	0.9	2.2	-0.1	0.2	-1.3	0.9	-1.5
Locomotion in novel chamber post-restriction	1.5	1.9	4.6	1.1	1.3	-2.2	-0.3	-1.3
Fecal boli incidents, locomotor time 1	0.8	0.9	2.2	0.2	0.8	-1.5	0.5	-1.2
Change in fecal boli incidents, locomotor task	0.6	0.6	1.3	-0.7	-1.0	1.1	0.3	0.5
Time >=10cm from walls, locomotor time 1	1.2	1.2	2.7	1.2	1.2	-1.6	-0.3	-0.8
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.5	0.2	-0.5	-0.1	-0.2
Total resting periods, locomotor time 1	0.2	0.2	0.6	0.1	-0.1	-0.6	0.4	-0.7
Rest time, locomotor task time 1	0.2	0.2	0.6	-0.2	-0.2	-0.3	0.6	-0.8
Distance moved, locomotor task time 1	0.5	0.6	1.3	0.4	0.4	0.4	-1.0	1.2
Vertical activity count, locomotor time 1	0.5	0.6	1.0	0.8	0.7	0.0	-1.0	0.9
Time >=10cm from walls, locomotor time 2	1.6	1.7	3.3	1.8	1.5	-1.0	-1.3	0.4
Bouts of movement, locomotor time 2	1.1	1.2	2.5	1.0	0.7	0.5	-1.3	1.6
Total resting periods, locomotor time 2	0.7	0.8	2.1	0.6	0.3	0.7	-0.9	1.4
Rest time, locomotor task time 2	2.4	2.7	4.1	-2.0	-2.0	1.7	1.6	-0.2
Distance moved, locomotor task time 2	2.9	3.3	5.3	2.3	2.1	-1.5	-2.0	0.6
Vertical activity count, locomotor time 2	1.5	1.7	2.5	1.6	1.5	-0.6	-1.5	1.0
Light reinforcement 1	2.2	3.9	6.1	-2.5	-2.4	2.1	1.7	0.0
Light reinforcement 2	0.7	1.0	1.5	-1.2	-0.9	0.1	1.2	-1.1
Bone: marrow area	1.3	2.9	4.8	1.9	1.8	-0.6	-2.2	1.5
Bone: maximum diameter	1.8	3.4	5.3	2.3	2.1	-1.1	-2.2	1.0
Bone: maximum force	0.0	0.1	0.2	0.4	0.2	0.0	-0.3	0.3
Bone: maximum moment	0.1	0.2	0.4	0.6	0.4	-0.2	-0.5	0.3
Mean time between licks in bursts	6.3	8.9	13.3	3.6	3.2	-1.1	-3.7	2.5
Mean num. licks in bursts	3.0	3.6	6.0	2.2	2.3	-2.5	-1.3	-0.7
Cd content in liver	0.4	0.5	1.1	-0.6	-0.5	1.0	-0.1	0.8
Co content in liver	2.0	2.3	3.5	1.9	1.6	-0.7	-1.9	1.1
Cu content in liver	1.2	1.5	2.6	1.4	1.2	-0.3	-1.6	1.2
Fe content in liver	0.0	0.0	0.1	0.0	-0.1	0.3	-0.2	0.3
K content in liver	0.3	0.3	0.6	-0.1	-0.4	0.7	-0.3	0.8
Mg content in liver	0.1	0.1	0.2	0.5	0.3	-0.3	-0.5	0.2
Mn content in liver	2.0	2.2	3.6	-1.7	-1.7	0.6	1.9	-1.2
Na content in liver	0.2	0.2	0.5	0.4	0.4	-0.7	-0.2	-0.5
Rb content in liver	0.7	0.9	1.3	1.1	1.2	-0.8	-1.0	0.2
Se content in liver	3.0	3.7	6.2	-2.4	-2.5	1.7	1.9	-0.4
Sr content in liver	0.4	0.3	0.9	-0.4	-0.2	-0.5	0.6	-0.9
Zn content in liver	3.5	3.9	5.9	2.2	2.4	-2.3	-1.7	-0.2
Bone: minimum diameter	1.5	2.8	5.2	1.6	1.2	0.5	-2.2	2.3
Time in familiar zone, hab. session 1	0.2	0.1	0.3	0.2	0.3	0.3	-0.5	0.5
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.5	-0.6	0.5	0.4	0.1
Total zone transitions, hab. session 1	0.3	0.4	1.2	-0.3	-0.4	-0.5	0.6	-1.1
Total locomotion distance, hab. session 1	1.1	1.5	3.8	-0.1	-0.6	1.7	-0.8	1.9
Locomotion velocity, hab. session 1	0.7	1.0	2.6	0.1	-0.5	1.3	-0.7	1.6
Time in familiar zone, hab. session 2	1.6	1.6	2.6	1.6	1.6	-1.0	-1.3	0.5
Time in novel zone, hab. session 2	0.6	0.6	1.0	-1.0	-0.9	0.3	0.9	-0.6
Total zone transitions, hab. session 2	0.9	1.2	2.6	1.1	1.0	-1.6	-0.3	-1.1
Total locomotion distance, hab. session 2	1.2	1.6	3.8	1.0	0.4	0.9	-1.4	2.0
Locomotion velocity, hab. session 2	1.4	1.9	4.7	0.9	0.3	1.2	-1.5	2.2
Novel to familiar place preference ratio	0.1	0.1	0.4	0.6	0.1	-0.0	-0.3	0.3
Novelty place preference	0.1	0.1	0.4	0.7	0.1	-0.0	-0.3	0.3
Time in novel zone, NPP test	0.2	0.2	0.7	0.9	0.3	-0.2	-0.4	0.2
Total zone transitions, NPP test	0.3	0.4	0.9	0.1	0.1	-0.9	0.3	-1.0
Total locomotion distance, NPP test	0.7	1.0	2.6	0.0	-0.3	1.3	-0.7	1.6
Locomotion velocity, NPP test	0.8	1.1	2.5	-0.4	-0.7	1.6	-0.4	1.6
Intraocular pressure	0.6	0.9	2.3	-0.5	0.1	-1.1	0.8	-1.5
Delta distance traveled before/after self-admin	1.3	1.4	2.6	1.5	1.1	-1.6	-0.5	-0.8
Delta ambulatory time before/after self-admin	1.3	1.5	3.3	1.2	1.0	-1.8	-0.1	-1.3
Parametrial fat weight	0.6	1.2	2.6	-1.1	-0.7	1.6	-0.1	1.2
Pavlov. Cond. lever latency	1.0	1.2	1.9	-1.4	-1.3	1.1	1.1	-0.2
Pavlov. Cond. magazine entry latency	2.6	3.4	5.2	2.3	2.2	-1.7	-1.9	0.4
Pavlov. Cond. change in total contacts	1.3	1.4	2.2	1.5	1.4	-1.1	-1.3	0.3
Pavlov. Cond. index score	2.5	3.2	4.8	2.2	2.2	-1.7	-1.9	0.4
Pavlov. Cond. latency score	2.4	3.1	4.7	2.2	2.1	-1.7	-1.8	0.4
Pavlov. Cond. lever contacts	1.1	1.3	1.9	1.4	1.4	-1.0	-1.3	0.4
Pavlov. Cond. magazine entry number	2.8	3.5	5.4	-2.3	-2.3	2.0	1.8	-0.1
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.4	-1.1	-1.2	1.0	0.9	-0.2
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	3.7	1.9	1.9	-1.5	-1.7	0.3
Pavlov. Cond. response bias	1.1	1.4	2.0	1.4	1.4	-1.0	-1.3	0.4
Pavlov. Cond. lever latency	14.8	19.9	31.0	-5.5	-5.6	4.6	4.2	-0.3
Pavlov. Cond. magazine entry latency	3.1	3.6	6.0	2.1	2.3	-2.4	-1.3	-0.7
Pavlov. Cond. change in total contacts	11.1	15.3	23.2	4.8	4.8	-4.2	-3.5	-0.1
Pavlov. Cond. index score	11.3	14.6	22.8	4.6	4.8	-4.1	-3.5	0.0
Pavlov. Cond. latency score	10.0	12.5	19.6	4.2	4.4	-3.9	-3.1	-0.1
Pavlov. Cond. lever contacts	15.4	21.0	32.7	5.6	5.7	-4.7	-4.3	0.3
Pavlov. Cond. magazine entry number	5.5	6.7	10.7	-2.9	-3.2	3.3	1.8	0.8
Pavlov. Cond. intertrial magazine entries	0.8	1.1	2.6	0.6	0.5	0.7	-1.3	1.6
Pavlov. Cond. lever-magazine prob. diff.	10.8	13.8	21.6	4.5	4.6	-3.9	-3.4	0.2
Pavlov. Cond. response bias	15.3	20.8	32.3	5.5	5.7	-4.8	-4.2	0.1
Time in closed arm before self-admin	2.0	2.3	5.1	1.0	0.7	-2.3	0.5	-2.1
Time in closed arm after self-admin	1.0	1.0	1.7	-1.0	-1.1	0.4	1.3	-0.8
Time in open arm before self-admin	3.7	4.0	6.7	-2.4	-2.3	2.6	1.3	0.8
Time in open arm after self-admin	0.6	0.7	1.3	0.5	0.7	0.2	-1.1	1.2
Bone: periosteal estimation	1.4	2.8	4.5	2.0	1.8	-0.7	-2.1	1.4
Bone: periosteal perimeter	1.5	2.5	3.7	1.9	1.8	-0.9	-1.9	1.0
Bone: post-yield work	0.1	0.1	0.3	0.5	0.4	-0.4	-0.3	-0.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	-0.2	0.1	0.1	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.0	-0.1	0.2	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.7	0.8	0.9	-0.8	-0.5	-0.0
Progressive ratio test 2 active lever presses	0.8	0.9	1.3	1.1	1.2	-0.7	-1.0	0.3
Progressive ratio test 2 breakpoint	0.9	1.0	1.5	1.2	1.2	-0.7	-1.1	0.4
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.6	1.0	1.0	-1.3	-0.3	-0.6
Incentive Sensitization - Responses	2.0	2.1	3.2	1.7	1.8	-1.0	-1.6	0.7
Incentive Sensitization - Breakpoint	1.7	1.7	2.8	1.6	1.7	-1.0	-1.4	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.4	-0.7	0.3	0.5	-0.4
Progressive ratio	0.2	0.2	0.6	-0.3	-0.2	-0.4	0.5	-0.8
Food seeking constrained by brief footshock	1.2	1.5	2.6	1.4	1.2	-0.2	-1.6	1.2
Seeking ratio, punishment vs. effort	1.6	2.0	3.3	1.4	1.3	0.1	-1.8	1.7
Retroperitoneal fat weight	3.1	10.3	22.6	-1.2	-1.7	4.7	-1.6	4.8
Reaction time number correct	0.5	0.7	2.0	-0.2	-0.3	-0.7	1.0	-1.4
Reaction time mean minus median	0.7	0.9	1.4	1.2	1.0	-0.6	-1.1	0.6
Reaction time mean minus median AUC	0.7	1.0	1.6	1.3	1.1	-1.1	-0.8	-0.0
Reaction time num false alarms	1.5	2.1	4.5	-1.4	-1.6	2.1	0.6	1.1
Reaction time num false alarms AUC	0.8	1.2	2.1	-1.1	-1.2	1.5	0.7	0.6
Reaction time trials correct on left	0.5	0.7	2.0	-0.2	-0.3	-0.7	1.0	-1.4
Reaction time trials on left	0.5	0.7	2.0	-0.2	-0.3	-0.7	1.0	-1.4
Reaction time mean	0.6	0.9	2.1	-0.6	-0.9	1.5	0.1	1.1
Reaction time mean AUC	0.7	1.0	2.2	-0.8	-1.1	1.5	0.4	0.8
Median of all reaction times	1.0	1.4	3.0	-1.1	-1.4	1.7	0.6	0.9
Reaction time omissions	0.3	0.4	0.9	-0.5	-0.7	0.9	0.1	0.6
Reaction time false alarm rate	1.0	1.5	3.3	-1.1	-1.1	1.8	0.3	1.2
Reaction time premature initiation rate	2.5	3.3	5.8	1.8	1.8	-0.2	-2.4	2.0
Reaction time premature initiations	1.2	1.7	2.5	1.6	1.5	-0.8	-1.6	0.9
Std. dev. reaction times	0.9	1.2	2.7	0.9	0.7	0.5	-1.3	1.6
Reaction time trials completed	0.5	0.7	2.0	-0.2	-0.3	-0.7	1.0	-1.4
Reaction time trials AUC	0.3	0.5	1.3	-0.1	-0.2	-0.6	0.8	-1.1
Run reversals in cocaine runway, females	2.9	2.8	7.4	0.4	0.5	1.6	-1.8	2.7
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.5	-0.3	-0.0	0.5	-0.4
Latency to leave start box in cocaine runway	1.6	1.8	3.8	-1.4	-1.4	1.9	0.3	1.0
Latency to leave start box in cocaine runway, F	1.6	1.7	4.0	-0.9	-1.0	2.0	-0.3	1.6
Latency to leave start box in cocaine runway, M	0.6	0.6	0.9	-0.9	-0.7	0.1	1.0	-0.8
Std. dev. time between licks in bursts	2.8	3.3	5.5	1.9	1.6	0.1	-2.3	2.2
Total sessions with >9 infusions	2.5	2.8	5.3	1.7	2.0	-2.3	-0.9	-0.9
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.3	-0.5	-0.4	0.2	0.5	-0.2
Short access day 1 total infusions	2.5	2.6	4.4	2.0	2.1	-1.7	-1.5	0.1
Short access day 10 total infusions	1.6	1.8	3.0	1.6	1.7	-1.1	-1.5	0.4
Short access total infusions	1.4	1.6	2.6	1.5	1.6	-1.2	-1.2	0.2
Short access day 1 locomotion	1.7	1.8	4.5	0.8	1.2	-2.1	0.1	-1.6
Short access day 10 total locomotion	0.2	0.2	0.4	0.6	0.5	-0.2	-0.6	0.4
Short access total locomotion	0.1	0.1	0.2	0.3	0.3	-0.5	-0.1	-0.3
One hour access (0.3 mA shock)	1.8	2.1	3.5	1.7	1.9	-1.6	-1.3	0.1
Compulsive drug intake	0.7	0.7	1.3	-0.8	-0.5	-0.4	1.1	-1.1
One hour access (shock baseline)	1.8	2.1	3.5	1.9	1.8	-1.1	-1.6	0.6
Social response proportion	0.4	0.4	1.2	-0.0	-0.2	0.8	-0.4	1.1
Social responses	1.0	1.3	3.8	0.4	0.0	1.3	-1.0	1.9
Social time	2.1	2.8	4.8	-1.9	-2.2	1.6	1.7	-0.4
Soleus weight	0.9	2.5	7.2	0.5	0.3	1.5	-1.7	2.7
Bone: stiffness	0.4	0.7	1.8	0.2	-0.2	1.1	-0.5	1.3
Tibialis anterior weight	0.2	0.8	1.5	0.8	0.6	0.3	-1.1	1.2
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.0	-0.3	0.1	0.1	-0.2
Time to tail flick, vehicle, after self-admin	2.1	2.2	4.9	1.5	1.6	-2.2	-0.6	-1.1
Time to tail flick, test, before self-admin	0.6	0.6	1.2	0.9	0.8	-0.2	-1.1	0.6
Time to tail flick, test, after self-admin	1.6	1.7	3.0	1.3	1.0	0.3	-1.7	1.6
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	3.6	1.0	1.5	-1.9	-0.4	-0.9
Delta time to tail flick, test, before/after SA	0.2	0.1	0.3	-0.3	-0.3	0.6	0.0	0.4
Tibia length	1.2	3.3	7.2	1.8	1.9	-2.7	-0.4	-1.5
Ambulatory time before self-admin	1.2	1.3	2.0	-1.4	-1.3	1.2	1.1	0.0
Ambulatory time after self-admin	0.9	1.0	2.6	-0.4	-0.7	-0.5	1.3	-1.6
Bone: tissue strength	1.5	1.5	3.1	-1.0	-0.8	-0.5	1.5	-1.7
Total heroin consumption	0.2	0.2	0.5	0.7	0.3	-0.7	-0.1	-0.5
Bone: trabecular number	1.1	1.6	2.4	-1.6	-1.4	0.5	1.5	-1.1
Bone: trabecular spacing	0.6	0.8	1.4	0.9	1.1	-1.2	-0.6	-0.4
Bone: trabecular thickness	0.2	0.3	0.7	-0.1	-0.5	0.9	-0.1	0.7
Bone: trabecular tissue density	1.8	2.6	6.1	-0.2	-0.8	2.3	-0.8	2.5
Water consumed over 24 hours	0.6	0.7	1.1	-1.0	-1.0	0.6	0.9	-0.4
Number of responses in last shaping day	0.3	0.4	0.5	0.6	0.7	-0.1	-0.7	0.6