All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.
| # | Tissue | Modality | RNA phenotype | h2 | h2 SE | h2 P | xQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | xQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NAcc | alternative polyA | XM_006245244.5 | 0.09 | 0.1 | 3.3e-03 | 0.02 | 0.01 | 0.02 | 0.02 | 1.6e-03 | 4.7e-03 | 3.7e-04 | 1.3e-03 |
| 2 | NAcc | alternative polyA | NM_001100760.1 | 0.13 | 0.12 | 2.0e-03 | 0.02 | 0.01 | 0.02 | 0.02 | 1.1e-03 | 3.0e-03 | 2.5e-04 | 8.1e-04 |
| 3 | NAcc | alternative polyA | NM_001100760.1 | 0.12 | 0.12 | 5.6e-03 | 0.01 | 0.01 | 0.01 | 0.01 | 2.8e-03 | 1.4e-02 | 2.3e-03 | 3.2e-03 |
| 4 | pVTA | gene expression | Retreg2 | 0.04 | 0.03 | 1.5e-03 | 0.03 | 0.03 | 0.02 | 0.03 | 2.5e-03 | 2.3e-03 | 7.4e-03 | 3.9e-03 |
| 5 | pVTA | intron excision ratio | chr9_84093659_84093730 | 0.04 | 0.03 | 1.9e-03 | 0.03 | 0.02 | 0.02 | 0.02 | 3.1e-03 | 8.8e-03 | 1.1e-02 | 1.1e-02 |
| 6 | pVTA | intron excision ratio | chr9_84093659_84093771 | 0.04 | 0.03 | 2.1e-03 | 0.03 | 0.02 | 0.02 | 0.02 | 3.7e-03 | 1.0e-02 | 1.2e-02 | 1.2e-02 |
| 7 | Adipose | gene expression | Retreg2 | 0.05 | 0.05 | 5.0e-05 | 0.03 | 0.03 | 0.03 | 0.03 | 1.0e-04 | 1.3e-04 | 2.6e-04 | 1.2e-04 |
| 8 | IL | alternative TSS | NM_001100760.1 | 0.18 | 0.16 | 4.1e-03 | 0.08 | 0.06 | 0.07 | 0.07 | 5.9e-03 | 1.3e-02 | 8.3e-03 | 8.5e-03 |
| 9 | Liver | alternative TSS | XM_017596525.2 | 0.02 | 0.03 | 4.3e-03 | 0.02 | 0.01 | 0.01 | 0.01 | 4.1e-03 | 7.0e-03 | 3.1e-02 | 6.8e-03 |
| 10 | Liver | gene expression | Retreg2 | 0.08 | 0.07 | 1.4e-07 | 0.05 | 0.06 | 0.06 | 0.06 | 3.5e-06 | 9.2e-07 | 5.0e-07 | 6.3e-07 |
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bone: apparent density | 546.2 | 940.5 | 9404.0 | 97.0 | -0.9 | -0.2 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.2 |
| Area under the delay curve | 2482.3 | 2890.7 | 28870.2 | -169.9 | 3.5 | 2.4 | 1.7 | 1.7 | -1.7 | 1.6 | 1.6 | -1.6 | 1.5 |
| BMI with tail | 86.8 | 299.4 | 2991.5 | -54.7 | 1.2 | 0.7 | 0.3 | 0.5 | -0.5 | 0.3 | 0.3 | -0.3 | 0.4 |
| BMI without tail | 5728.0 | 17474.3 | 174633.2 | 417.9 | -8.2 | -4.3 | -1.8 | -1.9 | 1.9 | -1.9 | -1.9 | 1.9 | -1.8 |
| Body weight | 1.3 | 5.9 | 16.0 | 4.0 | -2.3 | -2.2 | -2.2 | -2.0 | 2.0 | -2.2 | -2.2 | 2.2 | -2.2 |
| Weight adjusted by age | 7079.5 | 10734.9 | 107330.0 | 327.6 | -3.2 | -0.5 | 1.1 | 1.3 | -1.3 | 0.9 | 0.9 | -0.9 | 1.2 |
| Bone surface | 619.9 | 1128.8 | 11285.3 | 106.2 | -0.6 | 0.1 | 0.4 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.7 |
| Bone volume | 862.6 | 1546.2 | 15459.8 | 124.3 | -1.3 | -0.5 | -0.0 | 0.0 | -0.0 | 0.0 | 0.0 | -0.0 | 0.1 |
| Breakpoint value in progressive ratio session | 3761.5 | 4515.1 | 45139.9 | 212.5 | -2.8 | -0.7 | 0.7 | 0.6 | -0.6 | 0.7 | 0.7 | -0.7 | 0.7 |
| Number of licking bursts | 6744.1 | 10972.4 | 109696.9 | 331.2 | -4.7 | -2.0 | -0.4 | -0.3 | 0.3 | -0.5 | -0.5 | 0.5 | -0.3 |
| Context. condit. distance diff. score | 21.7 | 26.2 | 256.8 | -16.0 | -0.6 | -0.7 | -0.8 | -0.8 | 0.8 | -0.8 | -0.8 | 0.8 | -0.8 |
| Locomotion velocity, session 1 | 352.5 | 379.9 | 3796.8 | 61.6 | -1.0 | -0.6 | -0.3 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.2 |
| Locomotion distance, session 1 | 102.5 | 129.4 | 1293.5 | 36.0 | -0.3 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 |
| Locomotion velocity, session 2 | 216.7 | 252.1 | 2511.2 | 50.1 | 0.6 | 0.9 | 1.1 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.2 |
| Locomotion distance, session 2 | 53.9 | 75.1 | 708.1 | 26.6 | 1.9 | 2.1 | 2.2 | 2.2 | -2.2 | 2.2 | 2.2 | -2.2 | 2.2 |
| Locomotion velocity, session 3 | 52.2 | 59.6 | 578.7 | 24.1 | 1.1 | 1.3 | 1.4 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | 1.4 |
| Locomotion distance, session 3 | 401.0 | 436.3 | 4361.9 | -66.0 | 0.7 | 0.3 | 0.0 | 0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.0 |
| Stereotopy head waving bouts, day 3 | 136.2 | 159.6 | 1595.7 | -39.9 | 0.2 | -0.1 | -0.2 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.3 |
| Stereotopy head waving duration, day 3 | 287.3 | 342.7 | 3426.5 | -58.5 | 0.4 | -0.0 | -0.3 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 |
| Locomotion velocity, session 7 | 29.5 | 32.3 | 320.5 | 17.9 | 0.3 | 0.4 | 0.5 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.5 |
| Locomotion distance, session 7 | 85.8 | 108.4 | 1083.1 | 32.9 | 0.1 | 0.3 | 0.4 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Stereotopy head waving bouts, day 7 | 251.4 | 283.4 | 2828.2 | -53.2 | 1.2 | 0.9 | 0.7 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.6 |
| Stereotopy head waving duration, day 7 | 212.1 | 255.1 | 2545.1 | -50.4 | 1.3 | 0.9 | 0.7 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.7 |
| Locomotion velocity, session 8 | 42.3 | 50.8 | 491.3 | 22.2 | 1.2 | 1.3 | 1.4 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | 1.4 |
| Locomotion distance, session 8 | 15.0 | 21.8 | 214.6 | 14.6 | 0.5 | 0.6 | 0.6 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.7 |
| Degree of sensitization distance | 367.1 | 377.5 | 3774.8 | 61.4 | -0.6 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.2 |
| Degree of sensitization stereotypy | 205.2 | 222.8 | 2218.0 | -47.1 | 1.5 | 1.2 | 1.0 | 1.0 | -1.0 | 1.0 | 1.0 | -1.0 | 0.9 |
| Conditioned locomotion | 140.3 | 161.7 | 1613.9 | -40.2 | 0.1 | -0.4 | -0.6 | -0.7 | 0.7 | -0.6 | -0.6 | 0.6 | -0.6 |
| Cocaine response after cond. corrected | 1921.1 | 2314.7 | 23047.3 | 151.8 | -4.7 | -3.7 | -3.0 | -3.0 | 3.0 | -3.1 | -3.1 | 3.1 | -2.9 |
| Cocaine response after cond. not corrected | 1865.3 | 2192.8 | 21831.7 | 147.8 | -4.6 | -3.6 | -3.0 | -3.0 | 3.0 | -3.0 | -3.0 | 3.0 | -2.9 |
| Cocaine response before conditioning | 65.7 | 78.5 | 782.6 | -28.0 | 0.8 | 0.6 | 0.4 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Saline control response | 318.2 | 423.4 | 4205.4 | -64.8 | 2.5 | 2.0 | 1.6 | 1.6 | -1.6 | 1.6 | 1.6 | -1.6 | 1.6 |
| Bone: connectivity density | 166.8 | 260.4 | 2603.5 | 51.0 | -0.6 | -0.3 | -0.2 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.0 |
| Bone: cortical apparent density | 1202.4 | 1643.8 | 16433.0 | -128.2 | 1.7 | 0.9 | 0.4 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.2 |
| Bone: cortical area | 458.3 | 703.7 | 7035.9 | 83.9 | -0.6 | -0.0 | 0.3 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.4 |
| Bone: cortical porosity | 43.5 | 47.0 | 468.2 | -21.6 | 0.7 | 0.5 | 0.5 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Bone: cortical porosity | 111.3 | 120.8 | 1207.6 | 34.7 | -0.2 | 0.0 | 0.2 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 |
| Bone: cortical thickness | 37.5 | 62.1 | 621.2 | -24.9 | 0.3 | 0.1 | 0.0 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.1 |
| Bone: cortical thickness | 292.0 | 343.9 | 3437.1 | -58.6 | 0.9 | 0.5 | 0.2 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.3 |
| Bone: cortical tissue density | 1300.6 | 1770.6 | 17701.3 | -133.0 | 1.7 | 0.8 | 0.3 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.2 |
| Condit. Reinf. active minus inactive responses | 95.8 | 107.1 | 1071.2 | 32.7 | -0.4 | -0.1 | -0.0 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | 0.0 |
| Condit. Reinf. active-inactive response ratio | 24.6 | 26.2 | 258.5 | -16.1 | -0.5 | -0.6 | -0.6 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 |
| Condit. Reinf. active responses | 276.6 | 342.8 | 3428.1 | 58.5 | -0.5 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.2 |
| Condit. Reinf. inactive responses | 468.3 | 572.5 | 5722.5 | 75.6 | -0.3 | 0.2 | 0.5 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.6 |
| Incentive salience index mean | 354.1 | 435.2 | 4351.5 | 66.0 | -0.6 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.2 |
| Condit. Reinf. lever presses | 528.6 | 741.7 | 7411.8 | 86.1 | -1.5 | -0.9 | -0.6 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.5 |
| Condit. Reinf. active minus inactive responses | 1452.4 | 1881.0 | 18806.6 | -137.1 | 1.3 | 0.2 | -0.4 | -0.5 | 0.5 | -0.4 | -0.4 | 0.4 | -0.5 |
| Condit. Reinf. active-inactive response ratio | 2872.0 | 3326.0 | 33252.7 | -182.4 | 1.5 | 0.0 | -0.8 | -0.9 | 0.9 | -0.8 | -0.8 | 0.8 | -1.0 |
| Condit. Reinf. active responses | 230.3 | 320.8 | 3206.5 | -56.6 | 1.0 | 0.5 | 0.2 | 0.1 | -0.1 | 0.2 | 0.2 | -0.2 | 0.1 |
| Condit. Reinf. inactive responses | 1090.5 | 1412.9 | 14109.8 | 118.8 | 0.3 | 1.1 | 1.6 | 1.6 | -1.6 | 1.6 | 1.6 | -1.6 | 1.7 |
| Condit. Reinf. lever presses | 386.8 | 534.8 | 5342.7 | -73.1 | 1.6 | 0.9 | 0.6 | 0.5 | -0.5 | 0.6 | 0.6 | -0.6 | 0.5 |
| Condit. Reinf. lever reinforcers received | 47.1 | 65.6 | 654.3 | -25.6 | 0.8 | 0.5 | 0.4 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.3 |
| Conditioned reinforcement - actives | 10081.4 | 17220.4 | 172172.1 | 414.9 | -5.0 | -1.4 | 0.9 | 0.7 | -0.7 | 0.8 | 0.8 | -0.8 | 0.9 |
| Conditioned reinforcement - inactives | 6488.5 | 9536.5 | 95337.8 | 308.8 | -4.7 | -1.9 | -0.1 | -0.4 | 0.4 | -0.3 | -0.3 | 0.3 | -0.4 |
| Conditioned locomotion | 1035.1 | 1345.5 | 13431.8 | 115.9 | -0.1 | 1.1 | 1.8 | 1.8 | -1.8 | 1.7 | 1.7 | -1.7 | 1.7 |
| Patch foraging indifference point 0 sec | 3921.5 | 7248.5 | 72405.0 | 269.1 | -0.7 | 1.8 | 3.6 | 3.5 | -3.5 | 3.1 | 3.1 | -3.1 | 3.2 |
| Patch foraging indifference point AUC | 5014.2 | 7225.5 | 72235.1 | -268.8 | 4.2 | 1.6 | -0.0 | 0.0 | -0.0 | 0.3 | 0.3 | -0.3 | 0.2 |
| Delay disc. indifference point, 0s delay | 216.5 | 237.3 | 2366.3 | 48.6 | 0.4 | 0.7 | 0.9 | 0.9 | -0.9 | 1.0 | 1.0 | -1.0 | 1.0 |
| Delay disc. indifference point, 16s delay | 2197.0 | 2418.1 | 24169.7 | -155.5 | 2.4 | 1.4 | 0.7 | 0.8 | -0.8 | 0.7 | 0.7 | -0.7 | 0.5 |
| Delay disc. indifference point, 2s delay | 19.3 | 21.5 | 172.8 | 13.1 | 2.0 | 2.1 | 2.2 | 2.2 | -2.2 | 2.2 | 2.2 | -2.2 | 2.2 |
| Delay disc. indifference point, 24s delay | 3244.1 | 3638.1 | 36375.9 | -190.7 | 2.0 | 0.8 | -0.0 | 0.0 | -0.0 | -0.0 | -0.0 | 0.0 | -0.2 |
| Delay disc. indifference point, 4s delay | 63.2 | 66.4 | 647.3 | -25.4 | 1.6 | 1.4 | 1.3 | 1.3 | -1.3 | 1.3 | 1.3 | -1.3 | 1.3 |
| Delay disc. indifference point, 8s delay | 3340.1 | 3914.9 | 39103.4 | -197.7 | 3.9 | 2.7 | 1.8 | 1.9 | -1.9 | 1.8 | 1.8 | -1.8 | 1.6 |
| Indifference point function ln k | 5565.7 | 9729.0 | 97272.3 | 311.9 | -3.8 | -1.0 | 0.7 | 0.6 | -0.6 | 0.5 | 0.5 | -0.5 | 0.7 |
| Indifference point function log k | 5565.7 | 9729.0 | 97272.3 | 311.9 | -3.8 | -1.0 | 0.7 | 0.6 | -0.6 | 0.5 | 0.5 | -0.5 | 0.7 |
| Patch foraging total patch changes 0 sec | 4198.5 | 7897.8 | 78906.6 | 280.9 | -1.1 | 1.5 | 3.4 | 3.3 | -3.3 | 2.9 | 2.9 | -2.9 | 3.0 |
| Patch foraging total patch changes 12 sec | 233.6 | 302.6 | 2983.0 | 54.6 | 1.5 | 2.0 | 2.3 | 2.2 | -2.2 | 2.3 | 2.3 | -2.3 | 2.3 |
| Patch foraging total patch changes 18 sec | 4047.2 | 6176.2 | 61735.4 | 248.5 | -1.9 | 0.4 | 2.1 | 1.9 | -1.9 | 1.6 | 1.6 | -1.6 | 1.7 |
| Patch foraging total patch changes 24 sec | 7482.0 | 12839.1 | 128358.8 | 358.3 | -3.4 | -0.1 | 2.0 | 1.8 | -1.8 | 1.5 | 1.5 | -1.5 | 1.6 |
| Patch foraging total patch changes 6 sec | 780.5 | 1189.0 | 11862.7 | 108.9 | 0.1 | 1.2 | 2.1 | 1.9 | -1.9 | 2.0 | 2.0 | -2.0 | 1.8 |
| Patch foraging time to switch 0 sec | 6651.2 | 13607.6 | 136029.8 | 368.8 | -5.7 | -2.6 | -0.7 | -0.9 | 0.9 | -1.2 | -1.2 | 1.2 | -0.9 |
| Patch foraging water rate 0 sec | 6043.9 | 12709.1 | 127063.4 | -356.5 | 4.8 | 1.9 | 0.1 | 0.4 | -0.4 | 0.3 | 0.3 | -0.3 | 0.2 |
| Patch foraging water rate 12 sec | 7066.5 | 14785.7 | 147804.2 | -384.5 | 6.1 | 2.8 | 1.0 | 1.1 | -1.1 | 1.0 | 1.0 | -1.0 | 0.9 |
| Patch foraging water rate 18 sec | 3373.4 | 5218.3 | 52174.7 | -228.4 | 2.7 | 0.9 | -0.1 | 0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.2 |
| Patch foraging water rate 24 sec | 103.9 | 145.9 | 1450.7 | 38.1 | -0.1 | 0.6 | 1.2 | 1.2 | -1.2 | 1.0 | 1.0 | -1.0 | 0.9 |
| Patch foraging water rate 6 sec | 84.5 | 123.1 | 1221.1 | -34.9 | 1.7 | 1.2 | 0.9 | 0.9 | -0.9 | 0.9 | 0.9 | -0.9 | 1.0 |
| Seeking ratio, delayed vs. immediate footshock | 1344.6 | 1642.7 | 16425.5 | 128.2 | -1.1 | -0.4 | -0.1 | -0.1 | 0.1 | -0.0 | -0.0 | 0.0 | 0.2 |
| Distance traveled before self-admin | 5054.6 | 6629.0 | 66274.4 | 257.4 | -3.6 | -1.5 | -0.2 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.1 |
| Distance traveled after self-admin | 3248.1 | 3993.4 | 39913.6 | 199.8 | -0.9 | 0.7 | 1.7 | 1.6 | -1.6 | 1.6 | 1.6 | -1.6 | 1.7 |
| Extensor digitorum longus weight | 107.9 | 424.3 | 4238.5 | 65.1 | 0.1 | 0.5 | 0.6 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.8 |
| Bone: elastic displacement | 763.9 | 883.3 | 8793.6 | -93.8 | 2.9 | 2.3 | 1.9 | 1.9 | -1.9 | 1.9 | 1.9 | -1.9 | 1.8 |
| Bone: elastic work | 37.0 | 48.2 | 472.0 | -21.7 | 1.2 | 1.1 | 1.0 | 1.0 | -1.0 | 1.0 | 1.0 | -1.0 | 1.0 |
| Bone: endosteal estimation | 892.3 | 1955.2 | 19530.1 | 139.7 | 0.2 | 1.2 | 1.6 | 1.7 | -1.7 | 1.7 | 1.7 | -1.7 | 1.9 |
| Bone: endosteal perimeter | 1186.9 | 2526.1 | 25250.7 | 158.9 | -2.4 | -1.3 | -0.7 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.5 |
| Epididymis fat weight | 3629.5 | 12423.9 | 124176.0 | 352.4 | -6.4 | -3.2 | -1.0 | -1.3 | 1.3 | -1.5 | -1.5 | 1.5 | -1.3 |
| Delta time in closed arm before/after self-admin | 25.5 | 23.7 | 228.1 | 15.1 | 0.5 | 1.0 | 1.2 | 1.2 | -1.2 | 1.0 | 1.0 | -1.0 | 0.9 |
| Delta time in open arm before/after self-admin | 1517.7 | 1500.6 | 14959.9 | 122.3 | -3.5 | -2.6 | -1.9 | -2.1 | 2.1 | -1.9 | -1.9 | 1.9 | -1.9 |
| Diff in mean of infusions in LGA sessions | 3667.2 | 4464.8 | 44621.7 | -211.2 | 3.6 | 2.0 | 1.1 | 1.1 | -1.1 | 1.3 | 1.3 | -1.3 | 1.1 |
| Delay discount exponential model param | 1694.9 | 1887.5 | 18844.6 | 137.3 | -3.0 | -2.1 | -1.5 | -1.6 | 1.6 | -1.5 | -1.5 | 1.5 | -1.4 |
| Extinction: sum of active levers before priming | 2837.9 | 3128.4 | 31278.1 | 176.9 | -2.2 | -0.7 | 0.4 | 0.2 | -0.2 | 0.4 | 0.4 | -0.4 | 0.4 |
| Active lever presses in extinction session 6 | 74.9 | 74.5 | 735.5 | -27.1 | 1.3 | 1.0 | 0.9 | 0.9 | -0.9 | 1.1 | 1.1 | -1.1 | 1.1 |
| Bone: final force | 161.0 | 257.3 | 2557.4 | 50.6 | 0.8 | 1.2 | 1.4 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | 1.5 |
| Bone: final moment | 23.4 | 37.6 | 352.2 | 18.8 | 1.4 | 1.6 | 1.7 | 1.7 | -1.7 | 1.7 | 1.7 | -1.7 | 1.7 |
| Food consumed during 24 hour testing period | 3551.8 | 4891.9 | 48908.2 | -221.2 | 3.0 | 1.3 | 0.1 | 0.2 | -0.2 | 0.3 | 0.3 | -0.3 | 0.1 |
| Glucose | 54.2 | 85.2 | 852.1 | -29.2 | 0.4 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 |
| Heart weight | 307.6 | 475.8 | 4741.9 | -68.9 | 2.0 | 1.5 | 1.2 | 1.4 | -1.4 | 1.1 | 1.1 | -1.1 | 1.2 |
| Delay discount hyperbolic model param | 1231.0 | 1370.7 | 13670.7 | 116.9 | -3.0 | -2.3 | -1.8 | -1.8 | 1.8 | -1.8 | -1.8 | 1.8 | -1.7 |
| Intermittent access intake day 1-15 change | 12789.8 | 26222.8 | 262183.3 | 512.0 | -5.7 | -1.5 | 1.5 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.3 |
| Intermittent access intake escalation | 12609.0 | 25894.2 | 258898.7 | 508.8 | -5.6 | -1.4 | 1.5 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.3 |
| Intermittent access intake escalation 2 | 3618.7 | 4129.4 | 41280.9 | 203.2 | -1.3 | 0.2 | 1.4 | 1.2 | -1.2 | 1.3 | 1.3 | -1.3 | 1.4 |
| Intermitt. access day 1 inactive lever presses | 18065.0 | 68280.2 | 682662.5 | 826.2 | -10.9 | -4.3 | -0.4 | -0.9 | 0.9 | -0.7 | -0.7 | 0.7 | -0.2 |
| Intermitt. access day 15 inactive lever presses | 12365.0 | 25302.2 | 252935.7 | 502.9 | -8.0 | -3.6 | -0.7 | -1.3 | 1.3 | -1.2 | -1.2 | 1.2 | -1.1 |
| Intermitt. access escalation Index | 9331.2 | 13178.6 | 131765.3 | -363.0 | 4.1 | 1.1 | -0.9 | -0.7 | 0.7 | -0.6 | -0.6 | 0.6 | -0.7 |
| Intermittent access day 1 total infusions | 6613.3 | 10659.2 | 106564.8 | -326.4 | 4.8 | 2.0 | -0.2 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.1 |
| Intermittent access day 15 total infusions | 4873.9 | 7268.3 | 72671.5 | 269.6 | -2.9 | -0.6 | 0.8 | 0.6 | -0.6 | 0.5 | 0.5 | -0.5 | 0.6 |
| Intermittent access terminal intake (last 3 days) | 2480.5 | 3264.5 | 32639.1 | 180.7 | -1.6 | -0.1 | 0.8 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.7 |
| Intermittent access total infusions | 18.1 | 21.4 | 214.1 | -14.6 | 0.5 | 0.3 | 0.1 | 0.0 | -0.0 | 0.0 | 0.0 | -0.0 | 0.0 |
| Intermittent access day 1 locomotion | 3497.5 | 4449.9 | 44484.6 | -210.9 | 3.3 | 1.6 | 0.1 | 0.2 | -0.2 | 0.3 | 0.3 | -0.3 | 0.2 |
| Intermittent access day 15 total locomotion | 8556.5 | 15543.0 | 155401.1 | 394.2 | -4.2 | -0.8 | 1.6 | 1.3 | -1.3 | 1.1 | 1.1 | -1.1 | 1.2 |
| Intermittent access total locomotion | 12.4 | 14.9 | 139.4 | 11.8 | 1.1 | 1.2 | 1.1 | 1.0 | -1.0 | 1.0 | 1.0 | -1.0 | 1.0 |
| Intermittent access standard deviation | 11398.4 | 23736.9 | 237324.4 | 487.2 | -6.0 | -1.7 | 1.3 | 0.7 | -0.7 | 0.8 | 0.8 | -0.8 | 0.8 |
| Left kidney weight | 5505.9 | 25616.3 | 256104.2 | -506.1 | 7.2 | 2.5 | -0.5 | -0.2 | 0.2 | -0.0 | -0.0 | 0.0 | -0.2 |
| Right kidney weight | 4040.7 | 18404.0 | 184004.2 | -429.0 | 5.2 | 1.2 | -1.3 | -1.0 | 1.0 | -0.9 | -0.9 | 0.9 | -1.0 |
| Cocaine induced anxiety | 6912.2 | 9859.7 | 98562.3 | -313.9 | 5.2 | 2.3 | 0.4 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 |
| Post-drug Anxiety | 476.2 | 509.3 | 5084.1 | -71.3 | 2.2 | 1.2 | 0.4 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.7 |
| Baseline Anxiety | 3351.4 | 3882.0 | 38810.9 | 197.0 | -2.3 | -0.4 | 0.7 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 |
| Tail length | 2896.0 | 11308.8 | 112929.6 | 336.1 | -8.1 | -5.1 | -3.0 | -3.1 | 3.1 | -3.1 | -3.1 | 3.1 | -3.1 |
| Length with tail | 150.5 | 654.6 | 6454.9 | 80.3 | -4.1 | -3.4 | -2.9 | -2.9 | 2.9 | -3.0 | -3.0 | 3.0 | -3.0 |
| Length without tail | 4724.4 | 15219.4 | 152162.5 | -390.1 | 4.9 | 1.2 | -1.0 | -0.8 | 0.8 | -1.0 | -1.0 | 1.0 | -1.0 |
| Times rat made contact with spout | 7.2 | 8.2 | 82.3 | -9.1 | -0.2 | -0.0 | 0.2 | 0.2 | -0.2 | 0.1 | 0.1 | -0.1 | 0.0 |
| Lifetime Intake | 165.6 | 201.6 | 2014.5 | -44.9 | 0.9 | 0.5 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 |
| Liver weight, left | 348.8 | 576.8 | 5766.7 | -75.9 | 1.2 | 0.5 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.0 |
| Liver weight, right | 5.5 | 9.6 | 83.3 | -9.1 | -1.1 | -1.2 | -1.2 | -1.2 | 1.2 | -1.2 | -1.2 | 1.2 | -1.2 |
| Locomotor activity | 1.5 | 2.3 | 5.7 | 2.4 | 1.8 | 1.5 | 1.3 | 1.3 | -1.3 | 1.2 | 1.2 | -1.2 | 1.4 |
| Locomotor testing distance | 2770.3 | 4993.1 | 49856.9 | -223.3 | 5.5 | 3.4 | 2.1 | 2.2 | -2.2 | 2.1 | 2.1 | -2.1 | 2.2 |
| Locomotor testing rearing | 6347.1 | 12775.1 | 127603.6 | -357.2 | 7.9 | 4.9 | 3.0 | 3.1 | -3.1 | 2.9 | 2.9 | -2.9 | 2.9 |
| Locomotion in novel chamber | 390.7 | 499.1 | 4986.4 | -70.6 | 1.6 | 0.9 | 0.3 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.5 |
| Locomotion in novel chamber post-restriction | 6543.3 | 10681.4 | 106797.6 | -326.8 | 3.6 | 1.0 | -0.6 | -0.6 | 0.6 | -0.5 | -0.5 | 0.5 | -0.7 |
| Fecal boli incidents, locomotor time 1 | 6121.3 | 8878.2 | 88766.7 | -297.9 | 3.6 | 1.1 | -0.4 | -0.3 | 0.3 | -0.4 | -0.4 | 0.4 | -0.5 |
| Change in fecal boli incidents, locomotor task | 567.2 | 559.7 | 5595.0 | 74.8 | -0.5 | 0.1 | 0.5 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.5 |
| Time >=10cm from walls, locomotor time 1 | 1302.7 | 1380.7 | 13788.3 | -117.4 | 2.8 | 1.7 | 1.0 | 1.1 | -1.1 | 1.0 | 1.0 | -1.0 | 1.0 |
| Bouts of movement, locomotor time 1 | 1078.8 | 1225.5 | 12251.6 | 110.7 | -1.6 | -0.7 | -0.2 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.1 |
| Total resting periods, locomotor time 1 | 279.4 | 310.8 | 3107.8 | 55.7 | -0.4 | -0.0 | 0.2 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.3 |
| Rest time, locomotor task time 1 | 2235.3 | 2786.3 | 27858.4 | 166.9 | -2.0 | -0.5 | 0.2 | 0.2 | -0.2 | 0.1 | 0.1 | -0.1 | 0.3 |
| Distance moved, locomotor task time 1 | 6883.7 | 10283.2 | 102809.5 | -320.6 | 4.4 | 1.7 | 0.2 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.1 |
| Vertical activity count, locomotor time 1 | 14238.4 | 34161.7 | 341544.4 | -584.4 | 8.0 | 2.9 | 0.1 | 0.1 | -0.1 | 0.2 | 0.2 | -0.2 | -0.1 |
| Time >=10cm from walls, locomotor time 2 | 7116.9 | 10510.7 | 105092.8 | 324.2 | -3.2 | -0.7 | 0.6 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.9 |
| Bouts of movement, locomotor time 2 | 8204.4 | 13097.0 | 130945.4 | 361.9 | -4.7 | -1.5 | 0.2 | 0.2 | -0.2 | 0.1 | 0.1 | -0.1 | 0.3 |
| Total resting periods, locomotor time 2 | 9906.2 | 17344.0 | 173406.9 | 416.4 | -5.5 | -1.8 | 0.3 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.4 |
| Rest time, locomotor task time 2 | 2551.8 | 3237.7 | 32358.1 | -179.9 | 2.9 | 1.8 | 1.1 | 1.1 | -1.1 | 1.0 | 1.0 | -1.0 | 0.8 |
| Distance moved, locomotor task time 2 | 848.0 | 1011.2 | 10109.4 | 100.5 | -1.5 | -0.6 | -0.0 | -0.1 | 0.1 | 0.0 | 0.0 | -0.0 | 0.0 |
| Vertical activity count, locomotor time 2 | 5356.4 | 7372.0 | 73708.2 | -271.5 | 2.5 | 0.3 | -0.9 | -0.9 | 0.9 | -0.7 | -0.7 | 0.7 | -1.0 |
| Light reinforcement 1 | 6635.4 | 16275.3 | 162648.8 | -403.3 | 7.1 | 4.2 | 2.3 | 2.3 | -2.3 | 2.4 | 2.4 | -2.4 | 2.0 |
| Light reinforcement 2 | 3676.3 | 5657.1 | 56532.9 | -237.8 | 4.2 | 2.5 | 1.4 | 1.3 | -1.3 | 1.5 | 1.5 | -1.5 | 1.3 |
| Bone: marrow area | 944.0 | 2060.0 | 20577.8 | 143.4 | 0.2 | 1.1 | 1.6 | 1.7 | -1.7 | 1.7 | 1.7 | -1.7 | 1.9 |
| Bone: maximum diameter | 607.3 | 1133.6 | 11328.7 | 106.4 | -1.8 | -1.1 | -0.7 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.6 |
| Bone: maximum force | 871.2 | 1545.3 | 15427.3 | 124.2 | 0.5 | 1.4 | 1.8 | 1.8 | -1.8 | 1.8 | 1.8 | -1.8 | 2.0 |
| Bone: maximum moment | 600.9 | 1053.3 | 10497.9 | 102.5 | 1.0 | 1.7 | 2.1 | 2.1 | -2.1 | 2.1 | 2.1 | -2.1 | 2.2 |
| Mean time between licks in bursts | 11164.9 | 27339.7 | 273351.5 | 522.8 | -4.2 | -0.3 | 2.1 | 2.0 | -2.0 | 1.9 | 1.9 | -1.9 | 2.3 |
| Mean num. licks in bursts | 5677.2 | 8849.2 | 88457.5 | -297.4 | 4.6 | 2.4 | 1.1 | 1.0 | -1.0 | 1.1 | 1.1 | -1.1 | 0.8 |
| Cd content in liver | 0.0 | 0.0 | 0.0 | -0.2 | 0.2 | 0.2 | 0.2 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 |
| Co content in liver | 114.4 | 132.7 | 1314.8 | -36.3 | 1.5 | 1.3 | 1.1 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.1 |
| Cu content in liver | 4.1 | 4.9 | 47.4 | 6.9 | -0.5 | -0.5 | -0.4 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Fe content in liver | 134.9 | 163.9 | 1633.4 | -40.4 | 1.2 | 0.9 | 0.7 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.7 |
| K content in liver | 152.2 | 145.8 | 1455.9 | -38.2 | -0.1 | -0.4 | -0.6 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 |
| Mg content in liver | 602.8 | 615.2 | 6150.8 | -78.4 | 0.5 | -0.0 | -0.3 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.4 |
| Mn content in liver | 101.0 | 111.8 | 1117.5 | 33.4 | -0.1 | 0.1 | 0.2 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.3 |
| Na content in liver | 401.9 | 430.8 | 4306.9 | -65.6 | 0.7 | 0.3 | 0.0 | 0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.0 |
| Rb content in liver | 9.8 | 11.3 | 102.1 | -10.1 | -1.0 | -1.1 | -1.1 | -1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.1 |
| Se content in liver | 2.1 | 2.5 | 2.5 | 1.6 | -1.6 | -1.6 | -1.6 | -1.6 | 1.6 | -1.6 | -1.6 | 1.6 | -1.6 |
| Sr content in liver | 0.2 | 0.1 | 0.1 | -0.4 | 0.4 | 0.4 | 0.4 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Zn content in liver | 374.9 | 416.3 | 4158.9 | -64.5 | -0.1 | -0.5 | -0.7 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.8 |
| Bone: minimum diameter | 410.6 | 749.0 | 7480.3 | 86.5 | 0.2 | 0.8 | 1.1 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.2 |
| Time in familiar zone, hab. session 1 | 1121.1 | 1082.1 | 10779.9 | 103.8 | -3.0 | -2.3 | -2.0 | -2.0 | 2.0 | -2.0 | -2.0 | 2.0 | -1.8 |
| Time in novel zone, hab. session 1 | 925.3 | 925.4 | 9234.1 | -96.1 | 2.3 | 1.7 | 1.3 | 1.3 | -1.3 | 1.3 | 1.3 | -1.3 | 1.2 |
| Total zone transitions, hab. session 1 | 43.2 | 60.3 | 599.4 | -24.5 | 0.8 | 0.7 | 0.6 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.5 |
| Total locomotion distance, hab. session 1 | 39.5 | 55.9 | 557.8 | -23.6 | 0.5 | 0.4 | 0.3 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.3 |
| Locomotion velocity, hab. session 1 | 26.9 | 38.0 | 377.5 | -19.4 | 0.7 | 0.5 | 0.5 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.5 |
| Time in familiar zone, hab. session 2 | 590.5 | 623.6 | 6209.4 | 78.8 | -2.4 | -1.9 | -1.6 | -1.6 | 1.6 | -1.6 | -1.6 | 1.6 | -1.5 |
| Time in novel zone, hab. session 2 | 634.5 | 643.3 | 6398.9 | -80.0 | 2.6 | 2.1 | 1.8 | 1.8 | -1.8 | 1.8 | 1.8 | -1.8 | 1.7 |
| Total zone transitions, hab. session 2 | 6.4 | 8.2 | 81.8 | -9.0 | 0.0 | -0.0 | -0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 |
| Total locomotion distance, hab. session 2 | 2.2 | 2.9 | 29.0 | -5.4 | 0.1 | 0.0 | -0.0 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.0 |
| Locomotion velocity, hab. session 2 | 3.2 | 4.3 | 41.8 | -6.5 | -0.3 | -0.4 | -0.4 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Novel to familiar place preference ratio | 1535.1 | 1675.4 | 16742.4 | 129.4 | -2.2 | -1.4 | -0.9 | -0.9 | 0.9 | -0.9 | -0.9 | 0.9 | -0.7 |
| Novelty place preference | 1493.3 | 1606.1 | 16054.9 | 126.7 | -1.8 | -1.0 | -0.5 | -0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.4 |
| Time in novel zone, NPP test | 1068.8 | 1143.6 | 11433.1 | 106.9 | -1.4 | -0.7 | -0.3 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.2 |
| Total zone transitions, NPP test | 193.6 | 279.5 | 2794.4 | -52.9 | 0.6 | 0.2 | -0.0 | 0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.1 |
| Total locomotion distance, NPP test | 169.0 | 230.9 | 2305.1 | -48.0 | 1.1 | 0.7 | 0.5 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.5 |
| Locomotion velocity, NPP test | 95.5 | 134.6 | 1342.8 | -36.6 | 0.9 | 0.7 | 0.5 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.5 |
| Intraocular pressure | 1040.6 | 1496.8 | 14940.9 | -122.2 | 3.2 | 2.1 | 1.3 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | 1.3 |
| Delta distance traveled before/after self-admin | 297.6 | 315.0 | 3112.7 | -55.8 | 2.8 | 2.2 | 1.9 | 1.9 | -1.9 | 1.8 | 1.8 | -1.8 | 1.8 |
| Delta ambulatory time before/after self-admin | 3090.9 | 3809.3 | 38019.5 | -195.0 | 4.9 | 3.2 | 2.4 | 2.3 | -2.3 | 2.4 | 2.4 | -2.4 | 2.3 |
| Parametrial fat weight | 19.9 | 46.8 | 426.9 | 20.7 | -2.5 | -2.2 | -2.1 | -2.0 | 2.0 | -2.2 | -2.2 | 2.2 | -2.1 |
| Pavlov. Cond. lever latency | 49.5 | 62.3 | 619.2 | 24.9 | 0.4 | 0.6 | 0.7 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.7 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.1 | 0.1 | -0.3 | -0.2 | -0.2 | -0.2 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.2 |
| Pavlov. Cond. change in total contacts | 104.0 | 110.4 | 1101.8 | -33.2 | -0.2 | -0.4 | -0.6 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 |
| Pavlov. Cond. index score | 39.5 | 49.8 | 484.6 | -22.0 | -1.0 | -1.2 | -1.3 | -1.3 | 1.3 | -1.3 | -1.3 | 1.3 | -1.3 |
| Pavlov. Cond. latency score | 41.2 | 52.1 | 511.8 | -22.6 | -0.8 | -1.0 | -1.1 | -1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.1 |
| Pavlov. Cond. lever contacts | 68.3 | 81.6 | 808.4 | -28.4 | -0.6 | -0.8 | -1.0 | -1.0 | 1.0 | -1.0 | -1.0 | 1.0 | -1.0 |
| Pavlov. Cond. magazine entry number | 49.2 | 62.1 | 620.0 | 24.9 | 0.1 | 0.3 | 0.4 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Pavlov. Cond. intertrial magazine entries | 12.4 | 14.9 | 148.1 | 12.2 | -0.4 | -0.4 | -0.3 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 43.4 | 53.6 | 517.7 | -22.8 | -1.2 | -1.4 | -1.5 | -1.5 | 1.5 | -1.5 | -1.5 | 1.5 | -1.5 |
| Pavlov. Cond. response bias | 58.8 | 72.8 | 722.2 | -26.9 | -0.5 | -0.7 | -0.8 | -0.8 | 0.8 | -0.8 | -0.8 | 0.8 | -0.8 |
| Pavlov. Cond. lever latency | 253.7 | 344.9 | 3441.3 | -58.7 | -0.3 | -0.7 | -1.1 | -1.0 | 1.0 | -1.0 | -1.0 | 1.0 | -1.0 |
| Pavlov. Cond. magazine entry latency | 1328.5 | 1604.5 | 16041.6 | 126.7 | -1.6 | -0.7 | -0.1 | -0.1 | 0.1 | -0.2 | -0.2 | 0.2 | -0.1 |
| Pavlov. Cond. change in total contacts | 3981.7 | 6393.3 | 63924.0 | 252.8 | -2.7 | -0.9 | 0.4 | 0.3 | -0.3 | 0.2 | 0.2 | -0.2 | 0.4 |
| Pavlov. Cond. index score | 1274.8 | 1715.2 | 17147.8 | 130.9 | -0.7 | 0.2 | 0.9 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.8 |
| Pavlov. Cond. latency score | 1615.3 | 2141.6 | 21412.7 | 146.3 | -1.1 | -0.1 | 0.7 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.6 |
| Pavlov. Cond. lever contacts | 533.8 | 736.5 | 7356.2 | 85.8 | 0.1 | 0.7 | 1.3 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.1 |
| Pavlov. Cond. magazine entry number | 401.4 | 495.4 | 4952.7 | -70.4 | 0.5 | -0.1 | -0.5 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Pavlov. Cond. intertrial magazine entries | 3499.9 | 5268.2 | 52668.4 | -229.5 | 3.1 | 1.4 | 0.5 | 0.4 | -0.4 | 0.5 | 0.5 | -0.5 | 0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 1180.3 | 1572.7 | 15724.4 | 125.4 | -0.9 | 0.0 | 0.7 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.6 |
| Pavlov. Cond. response bias | 117.1 | 159.3 | 1584.5 | 39.8 | 0.5 | 0.8 | 1.2 | 1.0 | -1.0 | 1.0 | 1.0 | -1.0 | 1.0 |
| Time in closed arm before self-admin | 2687.6 | 3438.9 | 34376.0 | -185.4 | 1.5 | -0.4 | -1.4 | -1.4 | 1.4 | -1.1 | -1.1 | 1.1 | -1.1 |
| Time in closed arm after self-admin | 459.7 | 490.5 | 4898.7 | 70.0 | -0.2 | 0.6 | 1.0 | 1.0 | -1.0 | 0.9 | 0.9 | -0.9 | 0.9 |
| Time in open arm before self-admin | 876.6 | 957.2 | 9550.8 | -97.7 | 2.8 | 1.9 | 1.1 | 1.3 | -1.3 | 1.1 | 1.1 | -1.1 | 1.2 |
| Time in open arm after self-admin | 48.6 | 53.3 | 524.3 | 22.9 | -1.0 | -1.0 | -1.0 | -1.0 | 1.0 | -1.0 | -1.0 | 1.0 | -1.0 |
| Bone: periosteal estimation | 979.6 | 2066.0 | 20650.4 | 143.7 | -0.4 | 0.6 | 1.1 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.3 |
| Bone: periosteal perimeter | 1140.4 | 1961.7 | 19609.6 | 140.0 | -2.0 | -1.1 | -0.5 | -0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.4 |
| Bone: post-yield work | 1367.5 | 2003.9 | 20035.7 | 141.5 | -0.9 | 0.1 | 0.6 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.8 |
| Progressive ratio test 1 active lever presses | 3199.1 | 3955.5 | 39540.5 | 198.8 | -3.2 | -1.4 | -0.5 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.5 |
| Progressive ratio test 1 breakpoint | 3030.1 | 3706.0 | 37049.4 | 192.5 | -2.9 | -1.2 | -0.3 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 |
| Progressive ratio test 1 inactive lever presses | 6222.9 | 8966.3 | 89629.6 | 299.4 | -4.5 | -2.2 | -1.0 | -1.3 | 1.3 | -1.1 | -1.1 | 1.1 | -0.9 |
| Progressive ratio test 2 active lever presses | 1527.3 | 1787.7 | 17866.5 | -133.7 | 2.7 | 1.3 | 0.4 | 0.5 | -0.5 | 0.4 | 0.4 | -0.4 | 0.5 |
| Progressive ratio test 2 breakpoint | 854.8 | 977.0 | 9763.3 | -98.8 | 2.1 | 1.0 | 0.3 | 0.4 | -0.4 | 0.3 | 0.3 | -0.3 | 0.4 |
| Progressive ratio test 2 inactive lever presses | 7251.9 | 11766.8 | 117644.1 | 343.0 | -4.6 | -1.6 | 0.2 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.2 |
| Incentive Sensitization - Responses | 7137.6 | 10060.2 | 100562.7 | -317.1 | 5.6 | 2.4 | 0.4 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.7 |
| Incentive Sensitization - Breakpoint | 5529.6 | 7188.1 | 71852.6 | -268.1 | 4.8 | 2.0 | 0.3 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.5 |
| Sum of active levers in priming session hrs 5-6 | 98.1 | 91.2 | 909.5 | 30.2 | -0.4 | -0.6 | -0.6 | -0.6 | 0.6 | -0.5 | -0.5 | 0.5 | -0.3 |
| Progressive ratio | 6789.7 | 10639.1 | 106379.2 | -326.2 | 3.1 | 0.9 | -0.4 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.8 |
| Food seeking constrained by brief footshock | 189.0 | 231.4 | 2296.8 | -47.9 | 1.3 | 1.3 | 1.5 | 1.5 | -1.5 | 1.4 | 1.4 | -1.4 | 1.2 |
| Seeking ratio, punishment vs. effort | 4129.4 | 5957.2 | 59556.5 | 244.0 | -1.7 | 0.2 | 1.3 | 1.4 | -1.4 | 1.3 | 1.3 | -1.3 | 1.5 |
| Retroperitoneal fat weight | 396.3 | 1691.0 | 16805.0 | 129.6 | -5.0 | -3.8 | -3.0 | -3.0 | 3.0 | -3.1 | -3.1 | 3.1 | -3.0 |
| Reaction time number correct | 6348.8 | 12202.4 | 121994.0 | -349.3 | 5.0 | 2.0 | 0.2 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.2 |
| Reaction time mean minus median | 11998.0 | 29797.4 | 297900.1 | 545.8 | -7.9 | -3.1 | -0.2 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.4 |
| Reaction time mean minus median AUC | 12402.2 | 31450.5 | 314420.9 | 560.7 | -8.3 | -3.4 | -0.3 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.6 |
| Reaction time num false alarms | 1535.9 | 2165.3 | 21650.4 | -147.1 | 1.4 | 0.2 | -0.5 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.4 |
| Reaction time num false alarms AUC | 3502.3 | 5470.2 | 54693.1 | -233.9 | 2.8 | 0.8 | -0.4 | -0.2 | 0.2 | -0.1 | -0.1 | 0.1 | -0.3 |
| Reaction time trials correct on left | 6348.8 | 12202.4 | 121994.0 | -349.3 | 5.0 | 2.0 | 0.2 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.2 |
| Reaction time trials on left | 6089.9 | 11448.0 | 114451.3 | -338.3 | 4.9 | 2.0 | 0.2 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.2 |
| Reaction time mean | 2975.8 | 4732.1 | 47266.8 | 217.4 | -4.8 | -2.8 | -1.6 | -1.9 | 1.9 | -1.9 | -1.9 | 1.9 | -1.9 |
| Reaction time mean AUC | 3880.0 | 6199.1 | 61940.8 | 248.9 | -4.9 | -2.7 | -1.4 | -1.7 | 1.7 | -1.7 | -1.7 | 1.7 | -1.7 |
| Median of all reaction times | 792.6 | 1124.9 | 11202.6 | 105.8 | -3.5 | -2.5 | -1.8 | -2.0 | 2.0 | -2.0 | -2.0 | 2.0 | -2.1 |
| Reaction time omissions | 836.8 | 1220.9 | 12204.1 | 110.5 | -2.0 | -0.7 | 0.0 | -0.2 | 0.2 | -0.1 | -0.1 | 0.1 | -0.1 |
| Reaction time false alarm rate | 21.2 | 29.2 | 290.5 | 17.0 | -0.7 | -0.6 | -0.4 | -0.4 | 0.4 | -0.3 | -0.3 | 0.3 | -0.3 |
| Reaction time premature initiation rate | 973.6 | 1347.7 | 13473.8 | -116.1 | 1.5 | 0.4 | -0.3 | -0.4 | 0.4 | -0.1 | -0.1 | 0.1 | -0.1 |
| Reaction time premature initiations | 5375.5 | 9590.7 | 95886.6 | -309.7 | 4.2 | 1.5 | -0.3 | -0.2 | 0.2 | -0.0 | -0.0 | 0.0 | -0.1 |
| Std. dev. reaction times | 6089.5 | 11241.1 | 112354.5 | 335.2 | -5.8 | -3.0 | -1.1 | -1.5 | 1.5 | -1.4 | -1.4 | 1.4 | -1.4 |
| Reaction time trials completed | 6089.9 | 11448.0 | 114451.3 | -338.3 | 4.9 | 2.0 | 0.2 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.2 |
| Reaction time trials AUC | 6214.5 | 11858.3 | 118556.5 | -344.3 | 4.8 | 1.9 | 0.1 | 0.3 | -0.3 | 0.2 | 0.2 | -0.2 | 0.1 |
| Run reversals in cocaine runway, females | 940.8 | 939.1 | 9389.0 | -96.9 | 1.3 | 0.4 | -0.2 | 0.0 | -0.0 | 0.1 | 0.1 | -0.1 | 0.1 |
| Run reversals in cocaine runway, males | 769.5 | 773.8 | 7707.1 | 87.8 | -2.6 | -2.0 | -1.7 | -1.7 | 1.7 | -1.7 | -1.7 | 1.7 | -1.6 |
| Latency to leave start box in cocaine runway | 1629.6 | 1851.8 | 18511.7 | -136.1 | 1.8 | 1.0 | 0.5 | 0.6 | -0.6 | 0.5 | 0.5 | -0.5 | 0.4 |
| Latency to leave start box in cocaine runway, F | 716.7 | 819.5 | 8194.2 | -90.5 | 0.4 | 0.1 | -0.2 | 0.1 | -0.1 | -0.2 | -0.2 | 0.2 | -0.2 |
| Latency to leave start box in cocaine runway, M | 172.6 | 161.0 | 1600.9 | -40.0 | 1.4 | 1.1 | 0.9 | 0.9 | -0.9 | 0.9 | 0.9 | -0.9 | 0.9 |
| Std. dev. time between licks in bursts | 2975.8 | 4036.1 | 40351.2 | 200.9 | -1.7 | -0.1 | 1.0 | 1.1 | -1.1 | 0.9 | 0.9 | -0.9 | 1.1 |
| Total sessions with >9 infusions | 196.1 | 238.1 | 2379.3 | -48.8 | 0.8 | 0.7 | 0.3 | 0.4 | -0.4 | 0.3 | 0.3 | -0.3 | 0.2 |
| Short access day 1 total inactive lever presses | 3941.5 | 5181.3 | 51803.2 | -227.6 | 2.9 | 1.0 | -0.3 | -0.3 | 0.3 | -0.1 | -0.1 | 0.1 | -0.2 |
| Short access day 10 total inactive lever presses | 13887.8 | 33751.9 | 337432.6 | 580.9 | -8.4 | -3.5 | -0.5 | -1.0 | 1.0 | -0.7 | -0.7 | 0.7 | -0.5 |
| Short access day 1 total infusions | 3839.4 | 5084.4 | 50832.0 | -225.5 | 2.9 | 1.5 | 0.4 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.3 |
| Short access day 10 total infusions | 2270.0 | 2900.7 | 29002.7 | -170.3 | 1.9 | 0.6 | -0.4 | -0.2 | 0.2 | -0.3 | -0.3 | 0.3 | -0.4 |
| Short access total infusions | 878.1 | 1118.7 | 11183.5 | -105.8 | 1.5 | 0.8 | 0.1 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.1 |
| Short access day 1 locomotion | 2481.8 | 3075.9 | 30741.1 | 175.3 | -2.0 | 0.2 | 1.6 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | 1.3 |
| Short access day 10 total locomotion | 8819.8 | 16317.5 | 163136.6 | 403.9 | -5.7 | -1.6 | 1.0 | 0.6 | -0.6 | 0.7 | 0.7 | -0.7 | 0.5 |
| Short access total locomotion | 1868.4 | 2246.0 | 22452.3 | 149.8 | -2.0 | -0.1 | 0.9 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.6 |
| One hour access (0.3 mA shock) | 233.0 | 268.3 | 2682.5 | 51.8 | -0.5 | -0.2 | 0.3 | 0.2 | -0.2 | 0.1 | 0.1 | -0.1 | 0.2 |
| Compulsive drug intake | 1869.3 | 2222.6 | 22211.1 | -149.0 | 2.6 | 1.5 | 0.9 | 0.9 | -0.9 | 1.0 | 1.0 | -1.0 | 0.9 |
| One hour access (shock baseline) | 5500.2 | 8416.9 | 84148.8 | 290.1 | -4.0 | -1.7 | -0.3 | -0.4 | 0.4 | -0.6 | -0.6 | 0.6 | -0.3 |
| Social response proportion | 878.7 | 996.1 | 9950.1 | -99.8 | 0.4 | -0.7 | -1.4 | -1.3 | 1.3 | -1.1 | -1.1 | 1.1 | -1.1 |
| Social responses | 126.6 | 163.3 | 1633.0 | -40.4 | 0.3 | 0.0 | -0.2 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 |
| Social time | 1165.2 | 1589.6 | 15893.6 | 126.1 | -1.5 | -0.4 | 0.2 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 |
| Soleus weight | 3.2 | 9.5 | 61.0 | 7.8 | 1.8 | 1.9 | 1.9 | 2.0 | -2.0 | 2.0 | 2.0 | -2.0 | 2.0 |
| Bone: stiffness | 903.8 | 1471.0 | 14701.0 | 121.2 | -0.2 | 0.6 | 1.1 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.2 |
| Tibialis anterior weight | 116.3 | 394.3 | 3927.8 | -62.7 | 1.9 | 1.4 | 1.1 | 1.1 | -1.1 | 1.2 | 1.2 | -1.2 | 1.1 |
| Time to tail flick, vehicle, before self-admin | 1337.0 | 1389.4 | 13889.3 | 117.9 | -1.8 | -0.4 | 0.5 | 0.4 | -0.4 | 0.6 | 0.6 | -0.6 | 0.5 |
| Time to tail flick, vehicle, after self-admin | 4223.4 | 5589.4 | 55772.9 | 236.2 | -5.8 | -4.1 | -3.1 | -3.2 | 3.2 | -3.2 | -3.2 | 3.2 | -3.0 |
| Time to tail flick, test, before self-admin | 814.5 | 843.0 | 8424.8 | -91.8 | 0.5 | -0.5 | -0.9 | -0.9 | 0.9 | -0.7 | -0.7 | 0.7 | -0.8 |
| Time to tail flick, test, after self-admin | 140.6 | 146.0 | 1452.7 | 38.1 | -1.1 | -0.9 | -0.8 | -0.8 | 0.8 | -0.9 | -0.9 | 0.9 | -0.8 |
| Delta time to tail flick, vehicle, before/after SA | 989.1 | 942.6 | 9344.7 | 96.7 | -3.6 | -3.1 | -2.8 | -2.8 | 2.8 | -3.0 | -3.0 | 3.0 | -2.8 |
| Delta time to tail flick, test, before/after SA | 1568.7 | 1612.9 | 16127.0 | 127.0 | -1.4 | -0.4 | -0.0 | 0.1 | -0.1 | -0.1 | -0.1 | 0.1 | 0.1 |
| Tibia length | 76.9 | 211.9 | 2114.8 | 46.0 | -0.9 | -0.7 | -0.7 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.6 |
| Ambulatory time before self-admin | 7889.4 | 11799.2 | 117962.9 | 343.5 | -5.0 | -2.0 | -0.2 | -0.4 | 0.4 | -0.3 | -0.3 | 0.3 | -0.1 |
| Ambulatory time after self-admin | 2663.8 | 3132.6 | 31298.3 | 176.9 | -0.7 | 0.8 | 2.0 | 1.8 | -1.8 | 2.0 | 2.0 | -2.0 | 2.0 |
| Bone: tissue strength | 301.6 | 304.5 | 3025.1 | -55.0 | 2.0 | 1.6 | 1.5 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | 1.3 |
| Total heroin consumption | 24.7 | 28.9 | 282.0 | 16.8 | -0.8 | -1.0 | -0.9 | -1.0 | 1.0 | -0.8 | -0.8 | 0.8 | -0.8 |
| Bone: trabecular number | 1074.1 | 1775.0 | 17747.6 | 133.2 | -1.3 | -0.4 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.2 |
| Bone: trabecular spacing | 795.6 | 1055.6 | 10550.9 | -102.7 | 1.6 | 0.9 | 0.5 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.4 |
| Bone: trabecular thickness | 847.8 | 1059.0 | 10588.9 | 102.9 | -1.2 | -0.5 | 0.0 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | 0.0 |
| Bone: trabecular tissue density | 1455.7 | 2144.5 | 21441.4 | 146.4 | -0.9 | 0.1 | 0.7 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.8 |
| Water consumed over 24 hours | 3417.9 | 4590.3 | 45889.8 | -214.2 | 3.2 | 1.5 | 0.2 | 0.3 | -0.3 | 0.4 | 0.4 | -0.4 | 0.4 |
| Number of responses in last shaping day | 1363.8 | 1494.5 | 14923.9 | 122.2 | -2.7 | -1.6 | -1.3 | -1.3 | 1.3 | -1.2 | -1.2 | 1.2 | -1.2 |