All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.
| # | Tissue | Modality | RNA phenotype | h2 | h2 SE | h2 P | xQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | xQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NAcc | alternative polyA | XM_006245244.5 | 0.09 | 0.1 | 3.3e-03 | 0.02 | 0.01 | 0.02 | 0.02 | 1.6e-03 | 4.7e-03 | 3.9e-04 | 1.3e-03 |
| 2 | NAcc | alternative polyA | NM_001100760.1 | 0.13 | 0.12 | 2.0e-03 | 0.02 | 0.01 | 0.02 | 0.02 | 1.1e-03 | 3.0e-03 | 2.3e-04 | 7.9e-04 |
| 3 | NAcc | alternative polyA | NM_001100760.1 | 0.12 | 0.12 | 5.6e-03 | 0.01 | 0.01 | 0.01 | 0.01 | 2.8e-03 | 1.4e-02 | 2.4e-03 | 3.1e-03 |
| 4 | pVTA | gene expression | Retreg2 | 0.04 | 0.03 | 1.5e-03 | 0.03 | 0.03 | 0.02 | 0.03 | 2.5e-03 | 2.3e-03 | 7.4e-03 | 4.0e-03 |
| 5 | pVTA | intron excision ratio | chr9_84093659_84093730 | 0.04 | 0.03 | 1.9e-03 | 0.03 | 0.02 | 0.02 | 0.02 | 3.1e-03 | 8.8e-03 | 1.1e-02 | 1.1e-02 |
| 6 | pVTA | intron excision ratio | chr9_84093659_84093771 | 0.04 | 0.03 | 2.1e-03 | 0.03 | 0.02 | 0.02 | 0.02 | 3.7e-03 | 1.0e-02 | 1.2e-02 | 1.2e-02 |
| 7 | NAcc | alternative polyA | XM_006245244.5 | 0.08 | 0.1 | 9.5e-03 | 0.01 | 0.01 | 0.01 | 0.01 | 2.9e-03 | 6.1e-03 | 4.0e-03 | 3.2e-03 |
| 8 | Adipose | gene expression | Retreg2 | 0.05 | 0.05 | 5.0e-05 | 0.03 | 0.03 | 0.03 | 0.03 | 1.0e-04 | 1.3e-04 | 2.6e-04 | 1.2e-04 |
| 9 | IL | alternative TSS | NM_001100760.1 | 0.18 | 0.16 | 4.1e-03 | 0.08 | 0.06 | 0.07 | 0.07 | 5.9e-03 | 1.3e-02 | 8.3e-03 | 8.3e-03 |
| 10 | Liver | alternative TSS | XM_017596525.2 | 0.02 | 0.03 | 4.3e-03 | 0.02 | 0.01 | 0.01 | 0.02 | 4.1e-03 | 7.0e-03 | 3.1e-02 | 6.5e-03 |
| 11 | Liver | gene expression | Retreg2 | 0.08 | 0.07 | 1.4e-07 | 0.05 | 0.06 | 0.06 | 0.06 | 3.5e-06 | 9.2e-07 | 5.0e-07 | 6.0e-07 |
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bone: apparent density | 2024.5 | 3732.0 | 41050.4 | -202.6 | 1.3 | 0.2 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 |
| Area under the delay curve | 7421.3 | 11402.6 | 125384.0 | 354.1 | -4.2 | -2.4 | 1.7 | -1.7 | 1.7 | 1.7 | -1.6 | -1.6 | 1.6 | -1.5 |
| BMI with tail | 349.1 | 1218.5 | 13399.8 | 115.8 | -1.5 | -0.7 | 0.3 | -0.5 | 0.5 | 0.3 | -0.3 | -0.3 | 0.3 | -0.4 |
| BMI without tail | 13094.6 | 69841.2 | 768087.3 | -876.4 | 10.9 | 4.3 | -1.8 | 1.9 | -1.9 | -2.1 | 1.9 | 1.9 | -1.9 | 1.8 |
| Body weight | 1.4 | 5.9 | 17.1 | -4.1 | 2.3 | 2.2 | -2.2 | 2.0 | -2.0 | -2.2 | 2.2 | 2.2 | -2.2 | 2.2 |
| Weight adjusted by age | 14725.9 | 43107.1 | 474144.1 | -688.6 | 5.0 | 0.5 | 1.1 | -1.3 | 1.3 | 1.0 | -0.9 | -0.9 | 0.9 | -1.2 |
| Bone surface | 2284.3 | 4495.9 | 49451.2 | -222.4 | 1.1 | -0.1 | 0.4 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.7 |
| Bone volume | 3075.8 | 6127.7 | 67400.5 | -259.6 | 1.9 | 0.5 | -0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.1 |
| Breakpoint value in progressive ratio session | 10221.9 | 18488.2 | 203347.5 | -450.9 | 4.3 | 0.7 | 0.7 | -0.6 | 0.6 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 |
| Number of licking bursts | 14285.0 | 43436.4 | 477753.7 | -691.2 | 6.4 | 2.0 | -0.4 | 0.3 | -0.3 | -0.5 | 0.5 | 0.5 | -0.5 | 0.3 |
| Context. condit. distance diff. score | 88.6 | 107.4 | 1176.1 | 34.3 | 0.5 | 0.7 | -0.8 | 0.8 | -0.8 | -0.8 | 0.8 | 0.8 | -0.8 | 0.8 |
| Locomotion velocity, session 1 | 1328.9 | 1496.9 | 16463.8 | -128.3 | 1.2 | 0.6 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.2 |
| Locomotion distance, session 1 | 401.5 | 513.7 | 5650.1 | -75.2 | 0.5 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 |
| Locomotion velocity, session 2 | 851.6 | 1019.5 | 11203.7 | -105.8 | -0.4 | -0.9 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.2 |
| Locomotion distance, session 2 | 220.7 | 309.8 | 3360.9 | -58.0 | -1.8 | -2.1 | 2.2 | -2.2 | 2.2 | 2.2 | -2.2 | -2.2 | 2.2 | -2.2 |
| Locomotion velocity, session 3 | 213.5 | 245.2 | 2678.6 | -51.8 | -1.0 | -1.3 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | -1.4 | 1.4 | -1.4 |
| Locomotion distance, session 3 | 1510.6 | 1728.0 | 19007.3 | 137.9 | -1.0 | -0.3 | 0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.0 | 0.0 |
| Stereotopy head waving bouts, day 3 | 533.3 | 636.0 | 6995.2 | 83.6 | -0.4 | 0.1 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.3 |
| Stereotopy head waving duration, day 3 | 1103.0 | 1364.4 | 15007.4 | 122.5 | -0.6 | 0.0 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.3 |
| Locomotion velocity, session 7 | 119.3 | 131.1 | 1439.6 | -37.9 | -0.2 | -0.4 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.5 |
| Locomotion distance, session 7 | 340.5 | 435.0 | 4783.6 | -69.2 | 0.1 | -0.3 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Stereotopy head waving bouts, day 7 | 952.0 | 1106.8 | 12168.0 | 110.3 | -1.5 | -0.9 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.6 |
| Stereotopy head waving duration, day 7 | 804.9 | 993.8 | 10924.8 | 104.5 | -1.5 | -0.9 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 |
| Locomotion velocity, session 8 | 173.5 | 209.5 | 2285.9 | -47.8 | -1.1 | -1.3 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | -1.4 | 1.4 | -1.4 |
| Locomotion distance, session 8 | 61.4 | 89.3 | 978.4 | -31.3 | -0.4 | -0.6 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.7 |
| Degree of sensitization distance | 1391.8 | 1498.5 | 16483.2 | -128.4 | 0.8 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 |
| Degree of sensitization stereotypy | 773.4 | 861.0 | 9458.7 | 97.3 | -1.7 | -1.2 | 1.0 | -1.0 | 1.0 | 1.0 | -1.0 | -1.0 | 1.0 | -0.9 |
| Conditioned locomotion | 552.5 | 648.4 | 7128.5 | 84.4 | -0.4 | 0.4 | -0.6 | 0.7 | -0.7 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 |
| Cocaine response after cond. corrected | 5990.0 | 8952.1 | 98356.6 | -313.6 | 5.4 | 3.7 | -3.0 | 3.0 | -3.0 | -3.0 | 3.1 | 3.1 | -3.1 | 2.9 |
| Cocaine response after cond. not corrected | 5847.7 | 8476.1 | 93124.6 | -305.2 | 5.3 | 3.6 | -3.0 | 3.0 | -3.0 | -3.0 | 3.0 | 3.0 | -3.0 | 2.9 |
| Cocaine response before conditioning | 254.8 | 306.8 | 3372.3 | 58.1 | -1.0 | -0.6 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Saline control response | 1180.6 | 1632.9 | 17928.2 | 133.9 | -2.9 | -2.0 | 1.6 | -1.6 | 1.6 | 1.6 | -1.6 | -1.6 | 1.6 | -1.6 |
| Bone: connectivity density | 645.4 | 1029.8 | 11326.8 | -106.4 | 0.9 | 0.3 | -0.2 | 0.1 | -0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.0 |
| Bone: cortical apparent density | 4115.5 | 6494.4 | 71431.2 | 267.3 | -2.3 | -0.9 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.2 |
| Bone: cortical area | 1721.1 | 2798.8 | 30784.6 | -175.5 | 1.0 | 0.0 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.4 |
| Bone: cortical porosity | 167.2 | 181.9 | 1998.0 | 44.7 | -0.8 | -0.5 | 0.5 | -0.4 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Bone: cortical porosity | 437.1 | 481.0 | 5290.8 | -72.7 | 0.4 | -0.0 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.2 |
| Bone: cortical thickness | 147.9 | 246.5 | 2711.2 | 52.1 | -0.4 | -0.1 | 0.0 | 0.0 | -0.0 | -0.0 | 0.0 | 0.0 | -0.0 | 0.1 |
| Bone: cortical thickness | 1108.4 | 1354.6 | 14897.6 | 122.1 | -1.2 | -0.5 | 0.2 | -0.3 | 0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 |
| Bone: cortical tissue density | 4405.2 | 6998.8 | 76980.4 | 277.5 | -2.3 | -0.8 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.2 |
| Condit. Reinf. active minus inactive responses | 374.6 | 424.4 | 4667.7 | -68.3 | 0.5 | 0.1 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.0 |
| Condit. Reinf. active-inactive response ratio | 100.1 | 107.3 | 1176.1 | 34.3 | 0.4 | 0.6 | -0.6 | 0.7 | -0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.7 |
| Condit. Reinf. active responses | 1060.5 | 1362.3 | 14984.6 | -122.4 | 0.7 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 |
| Condit. Reinf. inactive responses | 1761.6 | 2284.3 | 25124.1 | -158.5 | 0.6 | -0.2 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.6 |
| Incentive salience index mean | 1343.9 | 1727.5 | 19001.3 | -137.8 | 0.9 | 0.2 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 |
| Condit. Reinf. lever presses | 1948.9 | 2917.7 | 32087.7 | -179.1 | 1.9 | 0.9 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.5 |
| Condit. Reinf. active minus inactive responses | 4855.9 | 7472.1 | 82187.0 | 286.7 | -2.1 | -0.2 | -0.4 | 0.5 | -0.5 | -0.4 | 0.4 | 0.4 | -0.4 | 0.5 |
| Condit. Reinf. active-inactive response ratio | 8326.3 | 13237.0 | 145595.6 | 381.6 | -2.5 | -0.0 | -0.8 | 0.9 | -0.9 | -0.8 | 0.8 | 0.8 | -0.8 | 1.0 |
| Condit. Reinf. active responses | 881.2 | 1264.2 | 13904.4 | 117.9 | -1.3 | -0.5 | 0.2 | -0.1 | 0.1 | 0.2 | -0.2 | -0.2 | 0.2 | -0.1 |
| Condit. Reinf. inactive responses | 3829.2 | 5674.9 | 62401.8 | -249.8 | 0.3 | -1.1 | 1.6 | -1.6 | 1.6 | 1.6 | -1.6 | -1.6 | 1.6 | -1.7 |
| Condit. Reinf. lever presses | 1443.5 | 2094.8 | 23035.2 | 151.8 | -2.0 | -1.0 | 0.6 | -0.5 | 0.5 | 0.6 | -0.6 | -0.6 | 0.6 | -0.5 |
| Condit. Reinf. lever reinforcers received | 182.0 | 255.3 | 2805.9 | 53.0 | -1.0 | -0.5 | 0.4 | -0.3 | 0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 |
| Conditioned reinforcement - actives | 17409.8 | 69054.1 | 759532.2 | -871.5 | 7.5 | 1.5 | 0.9 | -0.7 | 0.7 | 0.7 | -0.8 | -0.8 | 0.8 | -0.9 |
| Conditioned reinforcement - inactives | 14095.5 | 38495.4 | 423401.1 | -650.7 | 6.6 | 1.9 | -0.1 | 0.4 | -0.4 | -0.3 | 0.3 | 0.3 | -0.3 | 0.4 |
| Conditioned locomotion | 3760.4 | 5583.5 | 61391.8 | -247.8 | 0.9 | -1.0 | 1.8 | -1.8 | 1.8 | 1.7 | -1.7 | -1.7 | 1.7 | -1.7 |
| Patch foraging indifference point 0 sec | 10458.0 | 29434.9 | 323688.8 | -568.9 | 2.4 | -1.8 | 3.6 | -3.5 | 3.5 | 3.2 | -3.1 | -3.1 | 3.1 | -3.2 |
| Patch foraging indifference point AUC | 12102.8 | 28828.4 | 317075.0 | 563.1 | -5.9 | -1.6 | -0.0 | -0.0 | 0.0 | 0.2 | -0.3 | -0.3 | 0.3 | -0.2 |
| Delay disc. indifference point, 0s delay | 862.2 | 972.1 | 10686.0 | -103.4 | -0.2 | -0.7 | 0.9 | -0.9 | 0.9 | 0.9 | -1.0 | -1.0 | 1.0 | -1.0 |
| Delay disc. indifference point, 16s delay | 6801.3 | 9626.6 | 105877.0 | 325.4 | -3.0 | -1.4 | 0.7 | -0.8 | 0.8 | 0.8 | -0.7 | -0.7 | 0.7 | -0.5 |
| Delay disc. indifference point, 2s delay | 78.9 | 88.1 | 922.0 | -30.4 | -2.0 | -2.1 | 2.2 | -2.2 | 2.2 | 2.2 | -2.2 | -2.2 | 2.2 | -2.2 |
| Delay disc. indifference point, 24s delay | 9089.9 | 14499.9 | 159489.9 | 399.4 | -2.8 | -0.8 | -0.0 | -0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | 0.2 |
| Delay disc. indifference point, 4s delay | 231.3 | 244.9 | 2675.2 | 51.7 | -1.7 | -1.4 | 1.3 | -1.3 | 1.3 | 1.3 | -1.3 | -1.3 | 1.3 | -1.3 |
| Delay disc. indifference point, 8s delay | 9223.4 | 15468.0 | 170092.1 | 412.4 | -4.8 | -2.7 | 1.8 | -1.9 | 1.9 | 1.9 | -1.8 | -1.8 | 1.8 | -1.6 |
| Indifference point function ln k | 12910.8 | 39059.9 | 429623.3 | -655.5 | 5.7 | 1.1 | 0.7 | -0.6 | 0.6 | 0.6 | -0.5 | -0.5 | 0.5 | -0.7 |
| Indifference point function log k | 12910.8 | 39059.9 | 429623.3 | -655.5 | 5.7 | 1.1 | 0.7 | -0.6 | 0.6 | 0.6 | -0.5 | -0.5 | 0.5 | -0.7 |
| Patch foraging total patch changes 0 sec | 10935.8 | 32098.8 | 352999.3 | -594.1 | 2.9 | -1.5 | 3.4 | -3.3 | 3.3 | 3.0 | -2.9 | -2.9 | 2.9 | -3.0 |
| Patch foraging total patch changes 12 sec | 989.5 | 1325.9 | 14537.3 | -120.6 | -1.2 | -2.0 | 2.3 | -2.2 | 2.2 | 2.3 | -2.3 | -2.3 | 2.3 | -2.3 |
| Patch foraging total patch changes 18 sec | 10707.7 | 25218.9 | 277369.9 | -526.7 | 3.5 | -0.4 | 2.1 | -1.9 | 1.9 | 1.8 | -1.6 | -1.6 | 1.6 | -1.7 |
| Patch foraging total patch changes 24 sec | 15191.5 | 51949.4 | 571388.4 | -755.9 | 5.6 | 0.1 | 2.0 | -1.8 | 1.8 | 1.6 | -1.5 | -1.5 | 1.5 | -1.6 |
| Patch foraging total patch changes 6 sec | 2968.9 | 5017.9 | 55165.5 | -234.9 | 0.7 | -1.1 | 2.1 | -1.9 | 1.9 | 1.9 | -2.0 | -2.0 | 2.0 | -1.8 |
| Patch foraging time to switch 0 sec | 14239.8 | 54488.5 | 599299.2 | -774.1 | 7.7 | 2.6 | -0.7 | 0.9 | -0.9 | -1.0 | 1.2 | 1.2 | -1.2 | 0.9 |
| Patch foraging water rate 0 sec | 13529.2 | 51054.3 | 561547.7 | 749.4 | -6.7 | -1.9 | 0.1 | -0.4 | 0.4 | 0.3 | -0.3 | -0.3 | 0.3 | -0.2 |
| Patch foraging water rate 12 sec | 14716.3 | 59406.0 | 653382.2 | 808.3 | -8.2 | -2.9 | 1.0 | -1.1 | 1.1 | 1.1 | -1.0 | -1.0 | 1.0 | -0.9 |
| Patch foraging water rate 18 sec | 9389.7 | 20960.6 | 230551.1 | 480.2 | -3.8 | -0.9 | -0.1 | -0.0 | 0.0 | -0.0 | -0.0 | -0.0 | 0.0 | 0.2 |
| Patch foraging water rate 24 sec | 427.2 | 608.1 | 6679.1 | -81.7 | 0.6 | -0.6 | 1.2 | -1.2 | 1.2 | 1.1 | -1.0 | -1.0 | 1.0 | -0.9 |
| Patch foraging water rate 6 sec | 360.3 | 531.6 | 5834.9 | 76.4 | -2.1 | -1.2 | 0.9 | -0.9 | 0.9 | 0.9 | -0.9 | -0.9 | 0.9 | -1.0 |
| Seeking ratio, delayed vs. immediate footshock | 4490.7 | 6422.0 | 70640.1 | -265.8 | 1.5 | 0.4 | -0.1 | 0.1 | -0.1 | -0.0 | 0.0 | 0.0 | -0.0 | -0.2 |
| Distance traveled before self-admin | 12184.2 | 26574.0 | 292286.6 | -540.6 | 5.0 | 1.5 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.1 |
| Distance traveled after self-admin | 9166.9 | 16114.8 | 177236.1 | -421.0 | 2.1 | -0.7 | 1.7 | -1.6 | 1.6 | 1.6 | -1.6 | -1.6 | 1.6 | -1.7 |
| Extensor digitorum longus weight | 425.8 | 1699.8 | 18693.2 | -136.7 | 0.1 | -0.5 | 0.6 | -0.7 | 0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.8 |
| Bone: elastic displacement | 2696.6 | 3414.4 | 37512.5 | 193.7 | -3.3 | -2.3 | 1.9 | -1.9 | 1.9 | 1.9 | -1.9 | -1.9 | 1.9 | -1.8 |
| Bone: elastic work | 136.7 | 179.0 | 1958.0 | 44.2 | -1.3 | -1.1 | 1.0 | -1.0 | 1.0 | 1.0 | -1.0 | -1.0 | 1.0 | -1.0 |
| Bone: endosteal estimation | 3206.2 | 7840.9 | 86225.7 | -293.6 | 0.4 | -1.2 | 1.6 | -1.7 | 1.7 | 1.7 | -1.7 | -1.7 | 1.7 | -1.9 |
| Bone: endosteal perimeter | 4064.0 | 9963.4 | 109582.8 | -331.0 | 3.1 | 1.3 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.5 |
| Epididymis fat weight | 9860.3 | 49811.0 | 547823.5 | -740.2 | 8.5 | 3.2 | -1.0 | 1.3 | -1.3 | -1.4 | 1.5 | 1.5 | -1.5 | 1.3 |
| Delta time in closed arm before/after self-admin | 116.6 | 109.4 | 1193.7 | -34.5 | -0.2 | -1.0 | 1.2 | -1.2 | 1.2 | 1.1 | -1.0 | -1.0 | 1.0 | -0.9 |
| Delta time in open arm before/after self-admin | 4987.1 | 5888.5 | 64719.1 | -254.4 | 4.1 | 2.6 | -1.9 | 2.1 | -2.1 | -2.0 | 1.9 | 1.9 | -1.9 | 1.9 |
| Diff in mean of infusions in LGA sessions | 9864.6 | 17695.3 | 194611.8 | 441.1 | -4.6 | -2.0 | 1.1 | -1.1 | 1.1 | 1.1 | -1.3 | -1.3 | 1.3 | -1.1 |
| Delay discount exponential model param | 5476.5 | 7426.2 | 81651.5 | -285.7 | 3.6 | 2.1 | -1.5 | 1.6 | -1.6 | -1.6 | 1.5 | 1.5 | -1.5 | 1.4 |
| Extinction: sum of active levers before priming | 8325.6 | 12636.7 | 138992.0 | -372.8 | 3.2 | 0.7 | 0.4 | -0.2 | 0.2 | 0.3 | -0.4 | -0.4 | 0.4 | -0.4 |
| Active lever presses in extinction session 6 | 284.4 | 285.9 | 3133.2 | 56.0 | -1.5 | -1.0 | 0.9 | -0.9 | 0.9 | 0.9 | -1.1 | -1.1 | 1.1 | -1.1 |
| Bone: final force | 640.2 | 1044.5 | 11472.2 | -107.1 | -0.6 | -1.2 | 1.4 | -1.4 | 1.4 | 1.4 | -1.4 | -1.4 | 1.4 | -1.5 |
| Bone: final moment | 96.3 | 155.2 | 1680.3 | -41.0 | -1.4 | -1.6 | 1.7 | -1.7 | 1.7 | 1.7 | -1.7 | -1.7 | 1.7 | -1.7 |
| Food consumed during 24 hour testing period | 9655.1 | 19402.8 | 213411.5 | 462.0 | -4.2 | -1.3 | 0.1 | -0.2 | 0.2 | 0.3 | -0.3 | -0.3 | 0.3 | -0.1 |
| Glucose | 215.1 | 340.6 | 3746.7 | 61.2 | -0.6 | -0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 |
| Heart weight | 1229.1 | 1980.4 | 21765.7 | 147.5 | -2.2 | -1.5 | 1.2 | -1.4 | 1.4 | 1.2 | -1.1 | -1.1 | 1.1 | -1.2 |
| Delay discount hyperbolic model param | 4159.0 | 5357.5 | 58889.4 | -242.7 | 3.5 | 2.3 | -1.8 | 1.8 | -1.8 | -1.8 | 1.8 | 1.8 | -1.8 | 1.7 |
| Intermittent access intake day 1-15 change | 19147.4 | 104806.4 | 1152783.5 | -1073.7 | 8.6 | 1.5 | 1.5 | -1.1 | 1.1 | 1.0 | -1.1 | -1.1 | 1.1 | -1.3 |
| Intermittent access intake escalation | 19050.8 | 103630.7 | 1139853.9 | -1067.6 | 8.4 | 1.5 | 1.5 | -1.1 | 1.1 | 1.0 | -1.1 | -1.1 | 1.1 | -1.3 |
| Intermittent access intake escalation 2 | 9818.8 | 16503.3 | 181517.4 | -426.0 | 2.4 | -0.2 | 1.4 | -1.2 | 1.2 | 1.2 | -1.3 | -1.3 | 1.3 | -1.4 |
| Intermitt. access day 1 inactive lever presses | 21505.7 | 273889.9 | 3012537.1 | -1735.7 | 15.2 | 4.3 | -0.4 | 0.9 | -0.9 | -0.7 | 0.7 | 0.7 | -0.7 | 0.2 |
| Intermitt. access day 15 inactive lever presses | 18933.5 | 102032.8 | 1122216.4 | -1059.3 | 11.0 | 3.6 | -0.7 | 1.3 | -1.3 | -1.1 | 1.2 | 1.2 | -1.2 | 1.1 |
| Intermitt. access escalation Index | 16819.1 | 52733.4 | 580025.5 | 761.6 | -6.1 | -1.1 | -0.9 | 0.7 | -0.7 | -0.6 | 0.6 | 0.6 | -0.6 | 0.7 |
| Intermittent access day 1 total infusions | 14140.3 | 42249.7 | 464695.2 | 681.7 | -6.9 | -2.0 | -0.2 | 0.0 | -0.0 | 0.1 | 0.0 | 0.0 | -0.0 | 0.1 |
| Intermittent access day 15 total infusions | 11954.0 | 29287.9 | 322144.3 | -567.6 | 4.4 | 0.7 | 0.8 | -0.6 | 0.6 | 0.6 | -0.5 | -0.5 | 0.5 | -0.6 |
| Intermittent access terminal intake (last 3 days) | 7564.7 | 13240.8 | 145637.3 | -381.6 | 2.6 | 0.1 | 0.8 | -0.7 | 0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 |
| Intermittent access total infusions | 61.5 | 72.8 | 800.6 | 28.3 | -0.7 | -0.3 | 0.1 | -0.0 | 0.0 | 0.1 | -0.0 | -0.0 | 0.0 | -0.0 |
| Intermittent access day 1 locomotion | 9497.5 | 17466.3 | 192104.0 | 438.3 | -4.7 | -1.6 | 0.1 | -0.2 | 0.2 | 0.3 | -0.3 | -0.3 | 0.3 | -0.2 |
| Intermittent access day 15 total locomotion | 16168.3 | 62327.2 | 685545.3 | -828.0 | 6.4 | 0.8 | 1.6 | -1.3 | 1.3 | 1.1 | -1.1 | -1.1 | 1.1 | -1.2 |
| Intermittent access total locomotion | 65.5 | 78.6 | 853.8 | -29.2 | -1.1 | -1.2 | 1.1 | -1.0 | 1.0 | 1.0 | -1.0 | -1.0 | 1.0 | -1.0 |
| Intermittent access standard deviation | 18356.7 | 96048.1 | 1056440.1 | -1027.8 | 9.0 | 1.7 | 1.3 | -0.7 | 0.7 | 0.8 | -0.8 | -0.8 | 0.8 | -0.8 |
| Left kidney weight | 12843.1 | 103160.1 | 1134646.8 | 1065.2 | -10.4 | -2.5 | -0.5 | 0.2 | -0.2 | -0.1 | 0.0 | 0.0 | -0.0 | 0.2 |
| Right kidney weight | 10623.4 | 74244.3 | 816615.4 | 903.7 | -7.9 | -1.2 | -1.3 | 1.0 | -1.0 | -1.0 | 0.9 | 0.9 | -0.9 | 1.0 |
| Cocaine induced anxiety | 14572.9 | 39787.9 | 437607.3 | 661.5 | -7.2 | -2.3 | 0.4 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 |
| Post-drug Anxiety | 1861.1 | 2120.6 | 23314.3 | 152.7 | -2.9 | -1.2 | 0.4 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.7 |
| Baseline Anxiety | 9407.4 | 15778.9 | 173551.4 | -416.6 | 3.6 | 0.5 | 0.7 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 |
| Tail length | 8377.8 | 45021.9 | 495033.1 | -703.6 | 10.2 | 5.1 | -3.0 | 3.1 | -3.1 | -3.3 | 3.1 | 3.1 | -3.1 | 3.1 |
| Length with tail | 560.2 | 2482.2 | 27199.7 | -164.9 | 4.6 | 3.4 | -2.9 | 2.9 | -2.9 | -3.0 | 3.0 | 3.0 | -3.0 | 3.0 |
| Length without tail | 11756.8 | 61686.6 | 678489.6 | 823.7 | -7.4 | -1.3 | -1.0 | 0.8 | -0.8 | -0.9 | 1.0 | 1.0 | -1.0 | 1.0 |
| Times rat made contact with spout | 27.8 | 31.9 | 350.7 | 18.7 | 0.3 | 0.0 | 0.2 | -0.2 | 0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.0 |
| Lifetime Intake | 621.1 | 771.0 | 8479.5 | 92.1 | -1.2 | -0.6 | 0.1 | -0.1 | 0.1 | 0.2 | -0.1 | -0.1 | 0.1 | -0.1 |
| Liver weight, left | 1319.6 | 2280.1 | 25077.5 | 158.4 | -1.7 | -0.5 | -0.1 | 0.1 | -0.1 | -0.0 | -0.1 | -0.1 | 0.1 | 0.0 |
| Liver weight, right | 23.7 | 41.3 | 440.9 | 21.0 | 1.0 | 1.2 | -1.2 | 1.2 | -1.2 | -1.2 | 1.2 | 1.2 | -1.2 | 1.2 |
| Locomotor activity | 2.3 | 3.5 | 19.3 | -4.4 | -2.0 | -1.5 | 1.3 | -1.3 | 1.3 | 1.3 | -1.2 | -1.2 | 1.2 | -1.4 |
| Locomotor testing distance | 8135.3 | 19987.8 | 219768.8 | 468.8 | -6.9 | -3.4 | 2.1 | -2.2 | 2.2 | 2.2 | -2.1 | -2.1 | 2.1 | -2.2 |
| Locomotor testing rearing | 13860.7 | 50943.3 | 560182.3 | 748.5 | -9.9 | -4.9 | 3.0 | -3.1 | 3.1 | 3.1 | -2.9 | -2.9 | 2.9 | -2.9 |
| Locomotion in novel chamber | 1482.4 | 1992.3 | 21908.2 | 148.0 | -2.1 | -0.9 | 0.3 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.5 |
| Locomotion in novel chamber post-restriction | 14059.3 | 42332.5 | 465625.6 | 682.4 | -5.3 | -1.0 | -0.6 | 0.6 | -0.6 | -0.5 | 0.5 | 0.5 | -0.5 | 0.7 |
| Fecal boli incidents, locomotor time 1 | 13652.1 | 35807.8 | 393855.5 | 627.6 | -5.3 | -1.2 | -0.4 | 0.3 | -0.3 | -0.3 | 0.4 | 0.4 | -0.4 | 0.5 |
| Change in fecal boli incidents, locomotor task | 2134.9 | 2263.7 | 24898.4 | -157.8 | 0.9 | -0.1 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.5 |
| Time >=10cm from walls, locomotor time 1 | 4479.6 | 5566.7 | 61209.5 | 247.4 | -3.6 | -1.7 | 1.0 | -1.1 | 1.1 | 1.1 | -1.0 | -1.0 | 1.0 | -1.0 |
| Bouts of movement, locomotor time 1 | 3781.4 | 4902.5 | 53922.2 | -232.2 | 2.1 | 0.7 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.1 |
| Total resting periods, locomotor time 1 | 1073.0 | 1237.1 | 13607.2 | -116.6 | 0.6 | 0.0 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.3 |
| Rest time, locomotor task time 1 | 6905.2 | 11110.7 | 122208.1 | -349.6 | 2.9 | 0.5 | 0.2 | -0.2 | 0.2 | 0.2 | -0.1 | -0.1 | 0.1 | -0.3 |
| Distance moved, locomotor task time 1 | 14481.7 | 41029.9 | 451287.3 | 671.8 | -6.2 | -1.7 | 0.2 | -0.3 | 0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.1 |
| Vertical activity count, locomotor time 1 | 19916.6 | 137036.9 | 1507266.8 | 1227.7 | -11.4 | -3.0 | 0.1 | -0.1 | 0.1 | 0.1 | -0.2 | -0.2 | 0.2 | 0.1 |
| Time >=10cm from walls, locomotor time 2 | 14727.0 | 41884.2 | 460698.8 | -678.7 | 4.8 | 0.7 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.9 |
| Bouts of movement, locomotor time 2 | 15846.6 | 52542.0 | 577914.0 | -760.2 | 6.8 | 1.6 | 0.2 | -0.2 | 0.2 | 0.2 | -0.1 | -0.1 | 0.1 | -0.3 |
| Total resting periods, locomotor time 2 | 17281.5 | 69653.7 | 766124.5 | -875.3 | 7.9 | 1.8 | 0.3 | -0.2 | 0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.4 |
| Rest time, locomotor task time 2 | 7617.5 | 12851.7 | 141343.8 | 376.0 | -3.7 | -1.8 | 1.1 | -1.1 | 1.1 | 1.1 | -1.0 | -1.0 | 1.0 | -0.8 |
| Distance moved, locomotor task time 2 | 3115.7 | 4138.6 | 45519.3 | -213.4 | 2.1 | 0.7 | -0.0 | 0.1 | -0.1 | -0.1 | -0.0 | -0.0 | 0.0 | -0.0 |
| Vertical activity count, locomotor time 2 | 12583.9 | 29389.1 | 323259.1 | 568.6 | -4.0 | -0.3 | -0.9 | 0.9 | -0.9 | -0.9 | 0.7 | 0.7 | -0.7 | 1.0 |
| Light reinforcement 1 | 14115.8 | 64026.1 | 704145.3 | 839.1 | -9.0 | -4.2 | 2.3 | -2.3 | 2.3 | 2.4 | -2.4 | -2.4 | 2.4 | -2.0 |
| Light reinforcement 2 | 9811.1 | 22163.3 | 243745.1 | 493.7 | -5.4 | -2.5 | 1.4 | -1.3 | 1.3 | 1.5 | -1.5 | -1.5 | 1.5 | -1.3 |
| Bone: marrow area | 3370.7 | 8259.2 | 90826.5 | -301.4 | 0.5 | -1.1 | 1.6 | -1.7 | 1.7 | 1.7 | -1.7 | -1.7 | 1.7 | -1.9 |
| Bone: maximum diameter | 2218.8 | 4461.5 | 49066.8 | -221.5 | 2.3 | 1.1 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.6 |
| Bone: maximum force | 3142.6 | 6211.2 | 68293.5 | -261.3 | 0.1 | -1.4 | 1.8 | -1.8 | 1.8 | 1.8 | -1.8 | -1.8 | 1.8 | -2.0 |
| Bone: maximum moment | 2248.7 | 4253.3 | 46747.9 | -216.2 | -0.5 | -1.7 | 2.1 | -2.1 | 2.1 | 2.1 | -2.1 | -2.1 | 2.1 | -2.2 |
| Mean time between licks in bursts | 18138.2 | 108769.5 | 1196387.9 | -1093.8 | 6.8 | 0.4 | 2.1 | -2.0 | 2.0 | 1.9 | -1.9 | -1.9 | 1.9 | -2.3 |
| Mean num. licks in bursts | 12965.4 | 34942.6 | 384316.3 | 619.9 | -6.2 | -2.4 | 1.1 | -1.0 | 1.0 | 1.1 | -1.1 | -1.1 | 1.1 | -0.8 |
| Cd content in liver | 0.0 | 0.0 | 0.0 | 0.2 | -0.2 | -0.2 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.2 |
| Co content in liver | 430.4 | 505.8 | 5549.0 | 74.5 | -1.6 | -1.3 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.1 |
| Cu content in liver | 14.9 | 17.7 | 193.0 | -13.9 | 0.5 | 0.5 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Fe content in liver | 514.7 | 635.6 | 6984.7 | 83.6 | -1.3 | -0.9 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 |
| K content in liver | 599.7 | 586.1 | 6443.9 | 80.3 | -0.0 | 0.4 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 |
| Mg content in liver | 2226.9 | 2449.0 | 26936.8 | 164.1 | -0.8 | 0.0 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.4 |
| Mn content in liver | 397.7 | 446.1 | 4906.6 | -70.0 | 0.3 | -0.1 | 0.2 | -0.2 | 0.2 | 0.2 | -0.2 | -0.2 | 0.2 | -0.3 |
| Na content in liver | 1513.0 | 1705.8 | 18762.1 | 137.0 | -1.0 | -0.3 | 0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.0 | 0.0 |
| Rb content in liver | 39.9 | 46.5 | 499.0 | 22.3 | 1.0 | 1.1 | -1.1 | 1.1 | -1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.1 |
| Se content in liver | 2.1 | 2.5 | 2.5 | -1.6 | 1.6 | 1.6 | -1.6 | 1.6 | -1.6 | -1.6 | 1.6 | 1.6 | -1.6 | 1.6 |
| Sr content in liver | 0.2 | 0.1 | 0.1 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Zn content in liver | 1432.7 | 1668.7 | 18351.2 | 135.5 | -0.2 | 0.5 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.8 |
| Bone: minimum diameter | 1563.8 | 3005.0 | 33044.2 | -181.8 | 0.2 | -0.8 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.2 |
| Time in familiar zone, hab. session 1 | 3810.6 | 4193.0 | 46075.4 | -214.7 | 3.5 | 2.3 | -2.0 | 2.0 | -2.0 | -2.0 | 2.0 | 2.0 | -2.0 | 1.8 |
| Time in novel zone, hab. session 1 | 3231.3 | 3609.6 | 39681.9 | 199.2 | -2.7 | -1.7 | 1.3 | -1.3 | 1.3 | 1.3 | -1.3 | -1.3 | 1.3 | -1.2 |
| Total zone transitions, hab. session 1 | 165.6 | 232.2 | 2550.7 | 50.5 | -0.9 | -0.7 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.5 |
| Total locomotion distance, hab. session 1 | 153.4 | 218.3 | 2399.5 | 49.0 | -0.7 | -0.4 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | -0.3 | 0.3 | -0.3 |
| Locomotion velocity, hab. session 1 | 103.0 | 146.1 | 1604.6 | 40.1 | -0.8 | -0.5 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.5 |
| Time in familiar zone, hab. session 2 | 2127.8 | 2412.7 | 26509.5 | -162.8 | 2.7 | 1.9 | -1.6 | 1.6 | -1.6 | -1.6 | 1.6 | 1.6 | -1.6 | 1.5 |
| Time in novel zone, hab. session 2 | 2269.2 | 2480.3 | 27244.7 | 165.1 | -3.0 | -2.1 | 1.8 | -1.8 | 1.8 | 1.8 | -1.8 | -1.8 | 1.8 | -1.7 |
| Total zone transitions, hab. session 2 | 25.5 | 32.7 | 359.3 | 19.0 | -0.1 | 0.0 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 |
| Total locomotion distance, hab. session 2 | 8.8 | 11.5 | 126.5 | 11.2 | -0.1 | -0.0 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | 0.0 | -0.0 | 0.0 |
| Locomotion velocity, hab. session 2 | 13.3 | 17.8 | 194.7 | 14.0 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Novel to familiar place preference ratio | 5047.3 | 6590.2 | 72476.7 | -269.2 | 2.8 | 1.4 | -0.9 | 0.9 | -0.9 | -0.9 | 0.9 | 0.9 | -0.9 | 0.7 |
| Novelty place preference | 4944.6 | 6337.1 | 69699.0 | -264.0 | 2.4 | 1.0 | -0.5 | 0.5 | -0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.4 |
| Time in novel zone, NPP test | 3713.5 | 4519.0 | 49704.4 | -222.9 | 1.9 | 0.7 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.2 |
| Total zone transitions, NPP test | 748.2 | 1107.6 | 12182.7 | 110.4 | -0.8 | -0.2 | -0.0 | -0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.0 | 0.1 |
| Total locomotion distance, NPP test | 647.0 | 903.1 | 9929.4 | 99.6 | -1.3 | -0.7 | 0.5 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.5 |
| Locomotion velocity, NPP test | 367.6 | 524.4 | 5764.6 | 75.9 | -1.1 | -0.7 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.5 |
| Intraocular pressure | 3644.9 | 5949.1 | 65404.6 | 255.7 | -4.0 | -2.1 | 1.3 | -1.4 | 1.4 | 1.4 | -1.4 | -1.4 | 1.4 | -1.3 |
| Delta distance traveled before/after self-admin | 1134.0 | 1247.4 | 13678.7 | 117.0 | -3.2 | -2.2 | 1.9 | -1.9 | 1.9 | 1.8 | -1.8 | -1.8 | 1.8 | -1.8 |
| Delta ambulatory time before/after self-admin | 8735.1 | 15050.5 | 165464.7 | 406.8 | -6.0 | -3.2 | 2.4 | -2.3 | 2.3 | 2.4 | -2.4 | -2.4 | 2.4 | -2.3 |
| Parametrial fat weight | 57.8 | 136.1 | 1449.8 | -38.1 | 2.7 | 2.2 | -2.1 | 2.0 | -2.0 | -2.2 | 2.2 | 2.2 | -2.2 | 2.1 |
| Pavlov. Cond. lever latency | 199.9 | 253.3 | 2781.6 | -52.7 | -0.3 | -0.6 | 0.7 | -0.7 | 0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.7 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.6 | 0.8 | 0.2 | 0.2 | -0.2 | 0.2 | -0.2 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 |
| Pavlov. Cond. change in total contacts | 412.9 | 444.8 | 4890.2 | 69.9 | 0.1 | 0.4 | -0.6 | 0.6 | -0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.6 |
| Pavlov. Cond. index score | 161.9 | 205.2 | 2241.6 | 47.3 | 0.9 | 1.2 | -1.3 | 1.3 | -1.3 | -1.3 | 1.3 | 1.3 | -1.3 | 1.3 |
| Pavlov. Cond. latency score | 168.1 | 213.8 | 2341.2 | 48.4 | 0.7 | 1.0 | -1.1 | 1.1 | -1.1 | -1.1 | 1.1 | 1.1 | -1.1 | 1.1 |
| Pavlov. Cond. lever contacts | 276.1 | 332.5 | 3649.0 | 60.4 | 0.5 | 0.8 | -1.0 | 1.0 | -1.0 | -1.0 | 1.0 | 1.0 | -1.0 | 1.0 |
| Pavlov. Cond. magazine entry number | 196.6 | 249.6 | 2744.0 | -52.4 | 0.0 | -0.3 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Pavlov. Cond. intertrial magazine entries | 47.7 | 57.3 | 628.8 | -25.1 | 0.5 | 0.4 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 177.9 | 221.0 | 2411.1 | 49.1 | 1.1 | 1.4 | -1.5 | 1.5 | -1.5 | -1.5 | 1.5 | 1.5 | -1.5 | 1.5 |
| Pavlov. Cond. response bias | 237.4 | 295.8 | 3247.9 | 57.0 | 0.4 | 0.7 | -0.8 | 0.8 | -0.8 | -0.8 | 0.8 | 0.8 | -0.8 | 0.8 |
| Pavlov. Cond. lever latency | 992.6 | 1394.4 | 15330.5 | 123.8 | -0.0 | 0.7 | -1.1 | 1.0 | -1.0 | -0.9 | 1.0 | 1.0 | -1.0 | 1.0 |
| Pavlov. Cond. magazine entry latency | 4493.0 | 6355.5 | 69905.3 | -264.4 | 2.2 | 0.7 | -0.1 | 0.1 | -0.1 | -0.2 | 0.2 | 0.2 | -0.2 | 0.1 |
| Pavlov. Cond. change in total contacts | 10435.4 | 25403.5 | 279421.7 | -528.6 | 4.0 | 0.9 | 0.4 | -0.3 | 0.3 | 0.2 | -0.2 | -0.2 | 0.2 | -0.4 |
| Pavlov. Cond. index score | 4362.9 | 6847.1 | 75312.0 | -274.4 | 1.3 | -0.2 | 0.9 | -0.7 | 0.7 | 0.7 | -0.7 | -0.7 | 0.7 | -0.8 |
| Pavlov. Cond. latency score | 5316.3 | 8528.4 | 93806.9 | -306.3 | 1.7 | 0.1 | 0.7 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.6 |
| Pavlov. Cond. lever contacts | 2007.0 | 2963.8 | 32591.5 | -180.5 | 0.3 | -0.7 | 1.3 | -1.1 | 1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.1 |
| Pavlov. Cond. magazine entry number | 1525.0 | 1980.3 | 21781.6 | 147.6 | -0.9 | 0.1 | -0.5 | 0.4 | -0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 |
| Pavlov. Cond. intertrial magazine entries | 9540.3 | 20837.9 | 229195.3 | 478.7 | -4.2 | -1.5 | 0.5 | -0.4 | 0.4 | 0.5 | -0.5 | -0.5 | 0.5 | -0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 4079.5 | 6272.3 | 68990.2 | -262.7 | 1.5 | -0.0 | 0.7 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.6 |
| Pavlov. Cond. response bias | 470.6 | 650.2 | 7142.5 | -84.5 | -0.3 | -0.8 | 1.2 | -1.0 | 1.0 | 1.0 | -1.0 | -1.0 | 1.0 | -1.0 |
| Time in closed arm before self-admin | 8022.8 | 13944.6 | 153371.3 | 391.6 | -2.7 | 0.4 | -1.4 | 1.4 | -1.4 | -1.2 | 1.1 | 1.1 | -1.1 | 1.1 |
| Time in closed arm after self-admin | 1770.8 | 2009.3 | 22095.0 | -148.6 | 0.7 | -0.6 | 1.0 | -1.0 | 1.0 | 0.9 | -0.9 | -0.9 | 0.9 | -0.9 |
| Time in open arm before self-admin | 3146.4 | 3830.4 | 42107.8 | 205.2 | -3.4 | -1.9 | 1.1 | -1.3 | 1.3 | 1.3 | -1.1 | -1.1 | 1.1 | -1.2 |
| Time in open arm after self-admin | 173.0 | 191.0 | 2091.1 | -45.7 | 1.1 | 1.0 | -1.0 | 1.0 | -1.0 | -1.0 | 1.0 | 1.0 | -1.0 | 1.0 |
| Bone: periosteal estimation | 3472.3 | 8253.9 | 90780.3 | -301.3 | 1.0 | -0.6 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.3 |
| Bone: periosteal perimeter | 3926.2 | 7741.9 | 85150.5 | -291.8 | 2.6 | 1.1 | -0.5 | 0.5 | -0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.4 |
| Bone: post-yield work | 4622.8 | 7976.2 | 87732.9 | -296.2 | 1.5 | -0.1 | 0.6 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.8 |
| Progressive ratio test 1 active lever presses | 9080.5 | 15995.4 | 175926.7 | -419.4 | 4.2 | 1.4 | -0.5 | 0.6 | -0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.5 |
| Progressive ratio test 1 breakpoint | 8750.7 | 15020.9 | 165211.9 | -406.5 | 3.9 | 1.2 | -0.3 | 0.3 | -0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.3 |
| Progressive ratio test 1 inactive lever presses | 13738.1 | 35934.9 | 395235.5 | -628.7 | 5.9 | 2.2 | -1.0 | 1.3 | -1.3 | -1.1 | 1.1 | 1.1 | -1.1 | 0.9 |
| Progressive ratio test 2 active lever presses | 5203.1 | 7355.5 | 80893.3 | 284.4 | -3.7 | -1.3 | 0.4 | -0.5 | 0.5 | 0.5 | -0.4 | -0.4 | 0.4 | -0.5 |
| Progressive ratio test 2 breakpoint | 3180.4 | 4064.8 | 44702.4 | 211.4 | -2.9 | -1.0 | 0.3 | -0.4 | 0.4 | 0.4 | -0.3 | -0.3 | 0.3 | -0.4 |
| Progressive ratio test 2 inactive lever presses | 14919.9 | 47334.1 | 520628.8 | -721.5 | 6.6 | 1.6 | 0.2 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 |
| Incentive Sensitization - Responses | 14873.1 | 41015.6 | 451102.5 | 671.6 | -7.7 | -2.4 | 0.4 | -0.6 | 0.6 | 0.7 | -0.6 | -0.6 | 0.6 | -0.7 |
| Incentive Sensitization - Breakpoint | 12983.0 | 29479.0 | 324217.9 | 569.4 | -6.7 | -2.0 | 0.3 | -0.4 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.5 |
| Sum of active levers in priming session hrs 5-6 | 352.8 | 331.5 | 3644.3 | -60.4 | 0.4 | 0.5 | -0.6 | 0.6 | -0.6 | -0.5 | 0.5 | 0.5 | -0.5 | 0.3 |
| Progressive ratio | 14354.8 | 42295.9 | 465231.0 | 682.1 | -4.6 | -0.9 | -0.4 | 0.4 | -0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.8 |
| Food seeking constrained by brief footshock | 668.6 | 835.8 | 9174.6 | 95.8 | -1.2 | -1.3 | 1.5 | -1.5 | 1.5 | 1.4 | -1.4 | -1.4 | 1.4 | -1.2 |
| Seeking ratio, punishment vs. effort | 10753.8 | 23917.7 | 263071.6 | -512.9 | 2.9 | -0.2 | 1.3 | -1.4 | 1.4 | 1.3 | -1.3 | -1.3 | 1.3 | -1.5 |
| Retroperitoneal fat weight | 1462.1 | 6546.4 | 71886.6 | -268.1 | 5.9 | 3.8 | -3.0 | 3.0 | -3.0 | -3.1 | 3.1 | 3.1 | -3.1 | 3.0 |
| Reaction time number correct | 13952.8 | 49409.3 | 543448.0 | 737.2 | -7.0 | -2.1 | 0.2 | -0.4 | 0.4 | 0.3 | -0.4 | -0.4 | 0.4 | -0.2 |
| Reaction time mean minus median | 18711.9 | 119970.0 | 1319536.3 | -1148.7 | 11.0 | 3.2 | -0.2 | 0.6 | -0.6 | -0.6 | 0.6 | 0.6 | -0.6 | 0.4 |
| Reaction time mean minus median AUC | 18947.2 | 126517.3 | 1391539.6 | -1179.6 | 11.6 | 3.5 | -0.3 | 0.7 | -0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.6 |
| Reaction time num false alarms | 5189.0 | 8822.7 | 97043.9 | 311.5 | -2.1 | -0.2 | -0.5 | 0.3 | -0.3 | -0.4 | 0.3 | 0.3 | -0.3 | 0.4 |
| Reaction time num false alarms AUC | 9682.2 | 22167.3 | 243821.6 | 493.8 | -4.2 | -0.8 | -0.4 | 0.2 | -0.2 | -0.3 | 0.1 | 0.1 | -0.1 | 0.3 |
| Reaction time trials correct on left | 13952.8 | 49409.3 | 543448.0 | 737.2 | -7.0 | -2.1 | 0.2 | -0.4 | 0.4 | 0.3 | -0.4 | -0.4 | 0.4 | -0.2 |
| Reaction time trials on left | 13637.0 | 46344.8 | 509741.9 | 714.0 | -6.8 | -2.0 | 0.2 | -0.4 | 0.4 | 0.3 | -0.4 | -0.4 | 0.4 | -0.2 |
| Reaction time mean | 8583.0 | 18971.2 | 208612.1 | -456.7 | 6.0 | 2.8 | -1.6 | 1.9 | -1.9 | -1.9 | 1.9 | 1.9 | -1.9 | 1.9 |
| Reaction time mean AUC | 10306.3 | 24835.1 | 273117.2 | -522.6 | 6.3 | 2.8 | -1.4 | 1.7 | -1.7 | -1.7 | 1.7 | 1.7 | -1.7 | 1.7 |
| Median of all reaction times | 2859.3 | 4474.4 | 49162.8 | -221.7 | 4.1 | 2.5 | -1.8 | 2.0 | -2.0 | -2.0 | 2.0 | 2.0 | -2.0 | 2.1 |
| Reaction time omissions | 3115.8 | 5068.8 | 55747.7 | -236.1 | 2.8 | 0.8 | 0.0 | 0.2 | -0.2 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 |
| Reaction time false alarm rate | 81.1 | 112.2 | 1232.3 | -35.1 | 0.8 | 0.6 | -0.4 | 0.4 | -0.4 | -0.4 | 0.3 | 0.3 | -0.3 | 0.3 |
| Reaction time premature initiation rate | 3352.8 | 5202.4 | 57220.6 | 239.2 | -2.3 | -0.4 | -0.3 | 0.4 | -0.4 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 |
| Reaction time premature initiations | 12612.0 | 38236.0 | 420556.1 | 648.5 | -6.1 | -1.5 | -0.3 | 0.2 | -0.2 | -0.0 | 0.0 | 0.0 | -0.0 | 0.1 |
| Std. dev. reaction times | 13592.1 | 45214.5 | 497276.8 | -705.2 | 7.6 | 3.0 | -1.1 | 1.5 | -1.5 | -1.4 | 1.4 | 1.4 | -1.4 | 1.4 |
| Reaction time trials completed | 13637.0 | 46344.8 | 509741.9 | 714.0 | -6.8 | -2.0 | 0.2 | -0.4 | 0.4 | 0.3 | -0.4 | -0.4 | 0.4 | -0.2 |
| Reaction time trials AUC | 13791.9 | 48027.8 | 528255.5 | 726.8 | -6.8 | -1.9 | 0.1 | -0.3 | 0.3 | 0.2 | -0.2 | -0.2 | 0.2 | -0.1 |
| Run reversals in cocaine runway, females | 3379.8 | 3793.1 | 41720.8 | 204.3 | -1.8 | -0.4 | -0.2 | -0.0 | 0.0 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 |
| Run reversals in cocaine runway, males | 2717.6 | 2996.7 | 32927.7 | -181.5 | 3.0 | 2.0 | -1.7 | 1.7 | -1.7 | -1.7 | 1.7 | 1.7 | -1.7 | 1.6 |
| Latency to leave start box in cocaine runway | 5325.6 | 7325.0 | 80566.3 | 283.8 | -2.3 | -1.0 | 0.5 | -0.6 | 0.6 | 0.5 | -0.5 | -0.5 | 0.5 | -0.4 |
| Latency to leave start box in cocaine runway, F | 2580.0 | 3220.2 | 35421.8 | 188.2 | -0.6 | -0.0 | -0.2 | -0.1 | 0.1 | -0.1 | 0.2 | 0.2 | -0.2 | 0.2 |
| Latency to leave start box in cocaine runway, M | 650.1 | 619.9 | 6808.4 | 82.5 | -1.5 | -1.1 | 0.9 | -0.9 | 0.9 | 0.9 | -0.9 | -0.9 | 0.9 | -0.9 |
| Std. dev. time between licks in bursts | 8550.1 | 16083.9 | 176906.2 | -420.6 | 2.9 | 0.1 | 1.0 | -1.1 | 1.1 | 0.9 | -0.9 | -0.9 | 0.9 | -1.1 |
| Total sessions with >9 infusions | 723.2 | 898.9 | 9885.7 | 99.4 | -1.0 | -0.7 | 0.3 | -0.4 | 0.4 | 0.4 | -0.3 | -0.3 | 0.3 | -0.2 |
| Short access day 1 total inactive lever presses | 10400.2 | 20702.3 | 227705.8 | 477.2 | -4.2 | -1.0 | -0.3 | 0.3 | -0.3 | -0.1 | 0.1 | 0.1 | -0.1 | 0.2 |
| Short access day 10 total inactive lever presses | 19742.1 | 135773.5 | 1493356.6 | -1222.0 | 11.6 | 3.6 | -0.5 | 1.0 | -1.0 | -0.8 | 0.7 | 0.7 | -0.7 | 0.5 |
| Short access day 1 total infusions | 10135.4 | 20055.9 | 220596.6 | 469.7 | -3.8 | -1.5 | 0.4 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.3 |
| Short access day 10 total infusions | 6936.3 | 11447.0 | 125908.0 | 354.8 | -2.8 | -0.6 | -0.4 | 0.2 | -0.2 | -0.2 | 0.3 | 0.3 | -0.3 | 0.4 |
| Short access total infusions | 3086.3 | 4369.7 | 48061.1 | 219.2 | -2.0 | -0.8 | 0.1 | -0.2 | 0.2 | 0.3 | -0.2 | -0.2 | 0.2 | -0.1 |
| Short access day 1 locomotion | 7643.0 | 12668.3 | 139322.2 | -373.3 | 3.5 | -0.2 | 1.6 | -1.4 | 1.4 | 1.5 | -1.4 | -1.4 | 1.4 | -1.3 |
| Short access day 10 total locomotion | 16510.7 | 66843.7 | 735202.5 | -857.4 | 8.5 | 1.6 | 1.0 | -0.6 | 0.6 | 0.6 | -0.7 | -0.7 | 0.7 | -0.5 |
| Short access total locomotion | 6206.9 | 9386.8 | 103240.9 | -321.3 | 3.2 | 0.2 | 0.9 | -0.7 | 0.7 | 0.8 | -0.7 | -0.7 | 0.7 | -0.6 |
| One hour access (0.3 mA shock) | 879.1 | 1042.9 | 11470.5 | -107.1 | 0.8 | 0.2 | 0.3 | -0.2 | 0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 |
| Compulsive drug intake | 5950.3 | 8769.0 | 96438.1 | 310.5 | -3.4 | -1.5 | 0.9 | -0.9 | 0.9 | 0.9 | -1.0 | -1.0 | 1.0 | -0.9 |
| One hour access (shock baseline) | 12752.4 | 33385.6 | 367206.8 | -606.0 | 5.5 | 1.7 | -0.3 | 0.4 | -0.4 | -0.4 | 0.6 | 0.6 | -0.6 | 0.3 |
| Social response proportion | 3210.3 | 4070.6 | 44762.7 | 211.6 | -1.0 | 0.7 | -1.4 | 1.3 | -1.3 | -1.2 | 1.1 | 1.1 | -1.1 | 1.1 |
| Social responses | 516.6 | 678.1 | 7458.6 | 86.4 | -0.4 | 0.0 | -0.2 | 0.1 | -0.1 | -0.2 | 0.1 | 0.1 | -0.1 | 0.1 |
| Social time | 4022.0 | 6316.3 | 69474.1 | -263.6 | 2.1 | 0.4 | 0.2 | -0.2 | 0.2 | 0.1 | -0.2 | -0.2 | 0.2 | -0.2 |
| Soleus weight | 11.7 | 34.4 | 340.7 | -18.5 | -1.8 | -1.9 | 1.9 | -2.0 | 2.0 | 2.0 | -2.0 | -2.0 | 2.0 | -2.0 |
| Bone: stiffness | 3233.7 | 5882.0 | 64690.8 | -254.3 | 0.7 | -0.6 | 1.1 | -1.1 | 1.1 | 1.1 | -1.1 | -1.1 | 1.1 | -1.2 |
| Tibialis anterior weight | 444.3 | 1529.4 | 16805.8 | 129.6 | -2.3 | -1.4 | 1.1 | -1.1 | 1.1 | 1.1 | -1.2 | -1.2 | 1.2 | -1.1 |
| Time to tail flick, vehicle, before self-admin | 4667.6 | 5750.8 | 63248.8 | -251.5 | 2.7 | 0.4 | 0.5 | -0.4 | 0.4 | 0.4 | -0.6 | -0.6 | 0.6 | -0.5 |
| Time to tail flick, vehicle, after self-admin | 10759.8 | 21881.5 | 240551.7 | -490.5 | 6.9 | 4.1 | -3.1 | 3.2 | -3.2 | -3.2 | 3.2 | 3.2 | -3.2 | 3.0 |
| Time to tail flick, test, before self-admin | 2982.6 | 3424.1 | 37658.3 | 194.1 | -1.0 | 0.4 | -0.9 | 0.9 | -0.9 | -0.8 | 0.7 | 0.7 | -0.7 | 0.8 |
| Time to tail flick, test, after self-admin | 530.6 | 560.7 | 6159.8 | -78.5 | 1.3 | 0.9 | -0.8 | 0.8 | -0.8 | -0.8 | 0.9 | 0.9 | -0.9 | 0.8 |
| Delta time to tail flick, vehicle, before/after SA | 3329.0 | 3557.7 | 39043.3 | -197.6 | 3.9 | 3.1 | -2.8 | 2.8 | -2.8 | -2.8 | 3.0 | 3.0 | -3.0 | 2.8 |
| Delta time to tail flick, test, before/after SA | 5166.9 | 6387.2 | 70255.0 | -265.1 | 2.0 | 0.4 | -0.0 | -0.1 | 0.1 | -0.0 | 0.1 | 0.1 | -0.1 | -0.1 |
| Tibia length | 296.5 | 824.7 | 9066.4 | -95.2 | 0.9 | 0.7 | -0.7 | 0.7 | -0.7 | -0.7 | 0.7 | 0.7 | -0.7 | 0.6 |
| Ambulatory time before self-admin | 15554.3 | 47378.0 | 521105.4 | -721.9 | 6.9 | 2.0 | -0.2 | 0.4 | -0.4 | -0.3 | 0.3 | 0.3 | -0.3 | 0.1 |
| Ambulatory time after self-admin | 8022.9 | 12828.1 | 141074.7 | -375.6 | 1.8 | -0.8 | 2.0 | -1.8 | 1.8 | 1.9 | -2.0 | -2.0 | 2.0 | -2.0 |
| Bone: tissue strength | 1117.0 | 1169.7 | 12843.9 | 113.3 | -2.2 | -1.6 | 1.5 | -1.4 | 1.4 | 1.4 | -1.4 | -1.4 | 1.4 | -1.3 |
| Total heroin consumption | 88.0 | 103.6 | 1131.6 | -33.6 | 0.7 | 1.0 | -0.9 | 1.0 | -1.0 | -0.8 | 0.8 | 0.8 | -0.8 | 0.8 |
| Bone: trabecular number | 3740.0 | 7038.9 | 77424.1 | -278.3 | 1.9 | 0.4 | 0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 |
| Bone: trabecular spacing | 2844.8 | 4159.8 | 45750.0 | 213.9 | -2.1 | -0.9 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.4 |
| Bone: trabecular thickness | 3024.2 | 4193.5 | 46126.0 | -214.8 | 1.6 | 0.5 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.0 |
| Bone: trabecular tissue density | 4874.9 | 8537.4 | 93905.9 | -306.4 | 1.6 | -0.1 | 0.7 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | 0.6 | -0.8 |
| Water consumed over 24 hours | 9401.9 | 18206.4 | 200247.8 | 447.5 | -4.4 | -1.5 | 0.2 | -0.3 | 0.3 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 |
| Number of responses in last shaping day | 4664.5 | 6034.7 | 66355.4 | -257.6 | 3.3 | 1.6 | -1.3 | 1.3 | -1.3 | -1.2 | 1.2 | 1.2 | -1.2 | 1.2 |