Hub : Traits

Total heroin consumption

(sum of all infusions from LGA sessions 1-12) * 20

Tags: Behavior · Heroin

Project: u01_peter_kalivas

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr7	14449451	15768722	1	1	1.88e-09	2.87e-01	1.00e+00	LOC102551633
2	chr11	34321682	35720354	1	1	6.32e-08	2.66e-07	1.24e-01	Ets2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Extensor digitorum longus weight	2.93	1	0	0	0	1e+00	Ets2
Tibialis anterior weight	2.92	1	0	0	0	1e+00	Ets2
Patch foraging indifference point 0 sec	7.74	1	0	0	0	1e+00	LOC102551633
Patch foraging total patch changes 0 sec	7.23	1	0	0	0	1e+00	LOC102551633
Patch foraging total patch changes 6 sec	5.65	1	0	0	0	1e+00	LOC102551633
Patch foraging water rate 24 sec	4.27	1	0	0	0	1e+00	Ets2
Locomotor activity	4.19	1	0	0	0	1e+00	LOC102551633
Locomotor testing distance	3.92	1	0	0	0	1e+00	LOC102551633
Conditioned reinforcement - actives	6.27	1	0	0	0	1e+00	LOC102551633
Conditioned reinforcement - inactives	5.74	1	0	0	0	1e+00	LOC102551633
Conditioned locomotion	53.64	1	1	50	0	1e+00	LOC102551633
Intermittent access intake escalation 2	13.41	1	0	0	0	1e+00	LOC102551633
Intermitt. access escalation Index	57.91	1	1	50	0	1e+00	LOC102551633
Intermittent access day 1 total infusions	19.51	1	0	0	0	1e+00	LOC102551633
Intermittent access day 15 total infusions	6.27	1	0	0	0	1e+00	LOC102551633
Intermittent access terminal intake (last 3 days)	58.42	1	1	50	0	1e+00	LOC102551633
Intermittent access total infusions	12.85	1	0	0	0	1e+00	LOC102551633
Intermittent access day 15 total locomotion	18.79	2	1	50	0	1e+00	Ets2 LOC102551633
Intermittent access total locomotion	10	2	0	0	0	1e+00	Ets2 LOC102551633
Lifetime Intake	15.71	1	0	0	0	1e+00	LOC102551633
Incentive Sensitization - Responses	8.44	1	0	0	0	1e+00	LOC102551633
Incentive Sensitization - Breakpoint	6.89	1	0	0	0	1e+00	LOC102551633
Progressive ratio test 1 active lever presses	16.85	1	0	0	0	1e+00	LOC102551633
Progressive ratio test 1 breakpoint	36.73	1	1	50	0	1e+00	LOC102551633
Progressive ratio test 1 inactive lever presses	30.05	1	1	50	0	1e+00	LOC102551633
Progressive ratio test 2 inactive lever presses	22.31	1	0	0	0	1e+00	LOC102551633
Short access day 1 total inactive lever presses	7.07	1	0	0	0	1e+00	LOC102551633
Short access day 10 total inactive lever presses	17.14	1	0	0	0	1e+00	LOC102551633
Short access day 1 total infusions	71.59	1	1	50	0	1e+00	LOC102551633
Short access day 10 total infusions	30.94	1	1	50	0	1e+00	LOC102551633
Short access total infusions	43.84	1	1	50	0	1e+00	LOC102551633
Short access day 1 locomotion	22.2	1	0	0	0	1e+00	LOC102551633
One hour access (shock baseline)	6.09	1	0	0	0	1e+00	LOC102551633
Number of responses in last shaping day	16.84	1	0	0	0	1e+00	LOC102551633
Locomotion distance, session 3	4.8	1	0	0	0	1e+00	LOC102551633
Stereotopy head waving bouts, day 3	6.17	1	0	0	0	1e+00	Ets2
Stereotopy head waving duration, day 3	6.9	1	0	0	0	1e+00	Ets2
Locomotion distance, session 7	4.34	1	0	0	0	1e+00	Ets2
Degree of sensitization distance	11.08	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever latency	5.45	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. latency score	4.54	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	0	1e+00	LOC102551633
Bone: final force	3.95	1	0	0	0	1e+00	LOC102551633
Bone: final moment	3.68	1	0	0	0	1e+00	LOC102551633
Bone: maximum force	3.84	1	0	0	0	1e+00	LOC102551633
Bone: maximum moment	3.51	1	0	0	0	1e+00	LOC102551633
Bone: stiffness	4.72	1	0	0	0	1e+00	LOC102551633
Breakpoint value in progressive ratio session	9.9	1	0	0	0	1e+00	Ets2
Distance traveled before self-admin	53.87	1	1	50	0	1e+00	LOC102551633
Distance traveled after self-admin	46.63	1	1	50	0	1e+00	LOC102551633
Extinction: sum of active levers before priming	16.76	2	0	0	0	1e+00	Ets2 LOC102551633
Delta ambulatory time before/after self-admin	13.21	1	0	0	0	1e+00	LOC102551633
Time in closed arm after self-admin	7.57	2	0	0	0	1e+00	Ets2 LOC102551633
Time in open arm before self-admin	28.75	1	1	50	0	1e+00	LOC102551633
Time in open arm after self-admin	5.82	1	0	0	0	1e+00	LOC102551633
Sum of active levers in priming session hrs 5-6	14.47	2	0	0	0	1e+00	Ets2 LOC102551633
Time to tail flick, vehicle, before self-admin	53.6	1	1	50	0	1e+00	LOC102551633
Time to tail flick, vehicle, after self-admin	51.7	1	1	50	0	1e+00	LOC102551633
Delta time to tail flick, vehicle, before/after SA	122.63	1	1	50	0	1e+00	LOC102551633
Ambulatory time before self-admin	11.05	1	0	0	0	1e+00	LOC102551633
Ambulatory time after self-admin	16.68	1	0	0	0	1e+00	LOC102551633
Seeking ratio, delayed vs. immediate footshock	9.35	1	0	0	0	1e+00	LOC102551633
Co content in liver	12.69	1	0	0	0	1e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1e+00	LOC102551633
Na content in liver	44.6	1	1	50	0	1e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1e+00	LOC102551633

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.13
Adipose	alternative TSS	0	0	1.12
Adipose	gene expression	0	0	1.17
Adipose	isoform ratio	0	0	1.15
Adipose	intron excision ratio	0	0	1.08
Adipose	mRNA stability	0	0	1.19
BLA	alternative polyA	0	0	1.15
BLA	alternative TSS	0	0	1.15
BLA	gene expression	0	0	1.18
BLA	isoform ratio	0	0	1.15
BLA	intron excision ratio	0	0	1.14
BLA	mRNA stability	0	0	1.23
Brain	alternative polyA	0	0	1.18
Brain	alternative TSS	0	0	1.16
Brain	gene expression	0	0	1.2
Brain	isoform ratio	0	0	1.2
Brain	intron excision ratio	0	0	1.16
Brain	mRNA stability	0	0	1.21
Eye	alternative polyA	0	0	1.26
Eye	alternative TSS	0	0	1.49
Eye	gene expression	0	0	1.14
Eye	isoform ratio	0	0	1.16
Eye	intron excision ratio	0	0	1.14
Eye	mRNA stability	0	0	1.09
IL	alternative polyA	0	0	1.39
IL	alternative TSS	0	0	1.09
IL	gene expression	0	0	1.16
IL	isoform ratio	0	0	1.19
IL	intron excision ratio	0	0	1.16
IL	mRNA stability	0	0	1.24
LHb	alternative polyA	0	0	1.28
LHb	alternative TSS	0	0	1.26
LHb	gene expression	0	0	1.18
LHb	isoform ratio	0	0	1.25
LHb	intron excision ratio	0	0	1.05
LHb	mRNA stability	0	0	1.26
Liver	alternative polyA	0	0	1.13
Liver	alternative TSS	0	0	1.18
Liver	gene expression	0	0	1.17
Liver	isoform ratio	0	0	1.2
Liver	intron excision ratio	0	0	1.12
Liver	mRNA stability	0	0	1.21
NAcc	alternative polyA	0	0	1.24
NAcc	alternative TSS	0	0	1.09
NAcc	gene expression	0	0	1.18
NAcc	isoform ratio	0	0	1.2
NAcc	intron excision ratio	0	0	1.13
NAcc	mRNA stability	1	0	1.18
OFC	alternative polyA	0	0	1.29
OFC	alternative TSS	0	0	0.95
OFC	gene expression	0	0	1.18
OFC	isoform ratio	0	0	1.24
OFC	intron excision ratio	0	0	1.16
OFC	mRNA stability	0	0	1.2
PL	alternative polyA	0	0	1.18
PL	alternative TSS	0	0	1.12
PL	gene expression	0	0	1.18
PL	isoform ratio	0	0	1.21
PL	intron excision ratio	0	0	1.17
PL	mRNA stability	0	0	1.21
pVTA	alternative polyA	0	0	1.24
pVTA	alternative TSS	0	0	1.08
pVTA	gene expression	0	0	1.18
pVTA	isoform ratio	0	0	1.2
pVTA	intron excision ratio	0	0	1.07
pVTA	mRNA stability	0	0	1.24
RMTg	alternative polyA	1	0.2	1.31
RMTg	alternative TSS	0	0	1.12
RMTg	gene expression	0	0	1.16
RMTg	isoform ratio	0	0	1.14
RMTg	intron excision ratio	0	0	1.08
RMTg	mRNA stability	0	0	1.24