Hub : Traits

Total heroin consumption

(sum of all infusions from LGA sessions 1-12) * 20

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	11	34746237	36143622	1	1	2.66e-07	2.66e-07	1e+00	Get1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Intraocular pressure	4.15	1	0	0	0	1e+00	Get1
Extensor digitorum longus weight	0.99	1	0	0	0	1e+00	Get1
Soleus weight	1.43	1	0	0	0	1e+00	Get1
Delay discounting water rate 24 sec	4.26	1	0	0	0	1e+00	Get1
Intermittent access day 1 locomotion	4.06	1	0	0	0	1e+00	Get1
Intermittent access day 15 total locomotion	7	1	0	0	0	1e+00	Get1
Intermittent access total locomotion	8.94	1	0	0	0	1e+00	Get1
Progressive ratio test 2 inactive lever presses	4.45	1	0	0	0	1e+00	Get1
Stereotopy head waving bouts, day 3	6.78	1	0	0	0	1e+00	Get1
Stereotopy head waving duration, day 3	6.84	1	0	0	0	1e+00	Get1
Breakpoint value in progressive ratio session	8.82	1	0	0	0	1e+00	Get1
Diff in mean of infusions in LGA sessions	5.85	1	0	0	0	1e+00	Get1
Extinction: sum of active levers before priming	6.73	1	0	0	0	1e+00	Get1
Time in closed arm after self-admin	3.76	1	0	0	0	1e+00	Get1
Sum of active levers in priming session hrs 5-6	7.98	1	0	0	0	1e+00	Get1
Bouts of movement, locomotor time 2	4.59	1	0	0	0	1e+00	Get1
Total resting periods, locomotor time 2	4.19	1	0	0	0	1e+00	Get1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.26
Adipose	alternative TSS	0	0	1.13
Adipose	gene expression	0	0	1.17
Adipose	isoform ratio	0	0	1.17
Adipose	intron excision ratio	1	0	1.1
Adipose	mRNA stability	0	0	1.15
BLA	alternative polyA	0	0	1.32
BLA	alternative TSS	0	0	1.12
BLA	gene expression	0	0	1.2
BLA	isoform ratio	0	0	1.23
BLA	intron excision ratio	0	0	1.17
BLA	mRNA stability	0	0	1.2
Brain	alternative polyA	0	0	1.34
Brain	alternative TSS	0	0	1.15
Brain	gene expression	0	0	1.22
Brain	isoform ratio	0	0	1.3
Brain	intron excision ratio	0	0	1.17
Brain	mRNA stability	0	0	1.18
Eye	alternative polyA	0	0	1.32
Eye	alternative TSS	0	0	1.16
Eye	gene expression	0	0	1.16
Eye	isoform ratio	0	0	1.08
Eye	intron excision ratio	0	0	1.12
Eye	mRNA stability	0	0	1.37
IL	alternative polyA	0	0	1.43
IL	alternative TSS	0	0	1.06
IL	gene expression	0	0	1.21
IL	isoform ratio	0	0	1.17
IL	intron excision ratio	0	0	1.3
IL	mRNA stability	0	0	1.27
LHb	alternative polyA	0	0	1.32
LHb	alternative TSS	0	0	1.37
LHb	gene expression	0	0	1.18
LHb	isoform ratio	0	0	1.26
LHb	intron excision ratio	0	0	1.11
LHb	mRNA stability	0	0	1.17
Liver	alternative polyA	0	0	1.17
Liver	alternative TSS	0	0	1.16
Liver	gene expression	0	0	1.21
Liver	isoform ratio	0	0	1.2
Liver	intron excision ratio	0	0	1.16
Liver	mRNA stability	0	0	1.19
NAcc	alternative polyA	0	0	1.33
NAcc	alternative TSS	0	0	1.15
NAcc	gene expression	0	0	1.19
NAcc	isoform ratio	0	0	1.22
NAcc	intron excision ratio	0	0	1.19
NAcc	mRNA stability	0	0	1.16
OFC	alternative polyA	0	0	1.3
OFC	alternative TSS	0	0	1.18
OFC	gene expression	0	0	1.27
OFC	isoform ratio	0	0	1.2
OFC	intron excision ratio	0	0	1.26
OFC	mRNA stability	0	0	1.29
PL	alternative polyA	0	0	1.37
PL	alternative TSS	0	0	1.2
PL	gene expression	0	0	1.2
PL	isoform ratio	0	0	1.26
PL	intron excision ratio	0	0	1.21
PL	mRNA stability	0	0	1.18