Hub : Traits

Conditioned reinforcement - inactives

Tags: Behavior · Conditioned reinforcement

Project: p50_paul_meyer_2020

3 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 90392583 91787299 1 1 1.4e-08 7.9e-06 2.0e-86 -1845 Tcp11l1
2 8 108584253 109479622 1 1 1.6e-09 1.7e-02 1.1e-03 -87 Apeh
3 11 39057816 40174684 1 1 2.0e-09 2.4e-01 1.0e+00 100 Epha6

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heart weight 4.4 1 0 0 0 1 Epha6
Liver weight, left 4.0 1 0 0 0 1 Apeh
Parametrial fat weight 18.5 1 1 33 0 1 Epha6
Retroperitoneal fat weight 13.9 1 1 33 0 1 Tcp11l1
Intraocular pressure 5.2 1 0 0 0 1 Epha6
Tibialis anterior weight 3.4 1 0 0 0 1 Tcp11l1
Tibia length 2.4 1 0 0 0 1 Epha6
Food consumed during 24 hour testing period 5.0 1 0 0 0 1 Epha6
Times rat made contact with spout 14.6 1 0 0 0 1 Epha6
Std. dev. time between licks in bursts 6.9 1 0 0 0 1 Apeh
Water consumed over 24 hours 14.8 1 0 0 0 1 Epha6
Indifference point 0 sec 3.8 1 0 0 0 1 Apeh
Delay discounting total patch changes 12 sec 14.5 1 0 0 0 1 Epha6
Delay discounting total patch changes 18 sec 11.1 2 0 0 0 1 Epha6 Apeh
Delay discounting total patch changes 6 sec 9.2 2 0 0 0 1 Epha6 Apeh
Delay discounting water rate 18 sec 10.2 1 0 0 0 1 Epha6
Locomotor activity 7.9 1 0 0 0 1 Epha6
Locomotor testing distance 8.9 1 0 0 0 1 Epha6
Reaction time premature initiation rate 7.6 1 0 0 0 1 Epha6
Reaction time premature initiations 4.1 1 0 0 0 1 Epha6
Social response proportion 5.3 1 0 0 0 1 Tcp11l1
Social time 5.7 1 0 0 0 1 Tcp11l1
Conditioned locomotion 9.6 2 0 0 0 1 Epha6 Tcp11l1
Cocaine response after cond. corrected 7.2 1 0 0 0 1 Tcp11l1
Cocaine response before conditioning 5.9 2 0 0 0 1 Epha6 Tcp11l1
Saline control response 4.4 1 0 0 0 1 Apeh
Condit. Reinf. lever presses 6.4 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 5.9 1 0 0 0 1 Epha6
Pavlov. Cond. lever contacts 7.0 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry number 6.5 1 0 0 0 1 Epha6
Pavlov. Cond. response bias 4.5 1 0 0 0 1 Epha6
Conditioned reinforcement - actives 15.4 2 0 0 0 1 Epha6 Tcp11l1
Conditioned locomotion 6.1 2 0 0 0 1 Apeh Tcp11l1
Intermittent access intake day 1-15 change 26.8 1 1 33 0 1 Apeh
Intermittent access intake escalation 21.2 1 0 0 0 1 Apeh
Intermittent access intake escalation 2 29.8 1 1 33 0 1 Apeh
Intermitt. access day 1 inactive lever presses 5.8 1 0 0 0 1 Tcp11l1
Intermitt. access day 15 inactive lever presses 27.4 1 1 33 0 1 Apeh
Intermittent access day 1 total infusions 10.9 1 0 0 0 1 Epha6
Intermittent access day 15 total infusions 13.6 1 0 0 0 1 Epha6
Intermittent access terminal intake (last 3 days) 20.1 1 0 0 0 1 Epha6
Intermittent access total infusions 18.3 1 0 0 0 1 Epha6
Intermittent access standard deviation 34.3 1 1 33 0 1 Apeh
Cocaine induced anxiety 12.0 2 0 0 0 1 Epha6 Apeh
Post-drug Anxiety 5.9 1 0 0 0 1 Epha6
Baseline Anxiety 13.3 2 0 0 0 1 Epha6 Tcp11l1
Lifetime Intake 33.5 1 1 33 0 1 Epha6
Incentive Sensitization - Responses 8.4 2 0 0 0 1 Epha6 Apeh
Incentive Sensitization - Breakpoint 8.4 2 0 0 0 1 Epha6 Apeh
Progressive ratio test 1 active lever presses 17.3 2 0 0 0 1 Epha6 Apeh
Progressive ratio test 1 breakpoint 19.8 2 1 33 0 1 Epha6 Apeh
Progressive ratio test 1 inactive lever presses 8.4 2 0 0 0 1 Epha6 Apeh
Progressive ratio test 2 active lever presses 30.7 1 1 33 0 1 Epha6
Progressive ratio test 2 breakpoint 24.0 1 1 33 0 1 Epha6
Progressive ratio test 2 inactive lever presses 25.8 3 2 67 0 1 Epha6 Apeh Tcp11l1
Total sessions with >9 infusions 15.5 2 0 0 0 1 Epha6 Apeh
Short access day 1 total inactive lever presses 6.9 3 0 0 0 1 Epha6 Apeh Tcp11l1
Short access day 10 total inactive lever presses 40.3 1 1 33 0 1 Apeh
Short access day 1 total infusions 40.0 1 1 33 0 1 Epha6
Short access total infusions 43.9 1 1 33 0 1 Epha6
Short access day 10 total locomotion 6.4 1 0 0 0 1 Apeh
Short access total locomotion 10.7 1 0 0 0 1 Apeh
Compulsive drug intake 7.7 1 0 0 0 1 Apeh
One hour access (0.3 mA shock) 36.9 1 1 33 0 1 Epha6
One hour access (shock baseline) 19.7 1 0 0 0 1 Epha6
Number of responses in last shaping day 12.0 1 0 0 0 1 Apeh
Locomotion distance, session 1 11.4 1 0 0 0 1 Epha6
Stereotopy head waving bouts, day 3 8.9 1 0 0 0 1 Epha6
Locomotion velocity, session 7 7.7 1 0 0 0 1 Epha6
Locomotion distance, session 7 11.3 1 0 0 0 1 Epha6
Locomotion distance, session 8 5.5 1 0 0 0 1 Epha6
Degree of sensitization distance 6.1 1 0 0 0 1 Epha6
Condit. Reinf. active minus inactive responses 9.4 1 0 0 0 1 Epha6
Condit. Reinf. active-inactive response ratio 9.4 1 0 0 0 1 Epha6
Condit. Reinf. active responses 9.7 1 0 0 0 1 Epha6
Incentive salience index mean 10.8 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 11.0 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 1 9.8 1 0 0 0 1 Epha6
Time in novel zone, hab. session 1 6.2 1 0 0 0 1 Epha6
Total zone transitions, hab. session 1 8.1 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 1 4.8 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 1 8.1 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 2 37.3 1 1 33 0 1 Epha6
Time in novel zone, hab. session 2 30.0 1 1 33 0 1 Epha6
Total zone transitions, hab. session 2 7.4 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 2 8.9 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 2 9.0 1 0 0 0 1 Epha6
Novel to familiar place preference ratio 6.2 1 0 0 0 1 Apeh
Novelty place preference 6.4 2 0 0 0 1 Epha6 Apeh
Time in novel zone, NPP test 6.8 1 0 0 0 1 Apeh
Pavlov. Cond. lever latency 19.5 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry latency 20.3 2 1 33 0 1 Epha6 Apeh
Pavlov. Cond. change in total contacts 8.2 1 0 0 0 1 Epha6
Pavlov. Cond. index score 29.2 1 1 33 0 1 Epha6
Pavlov. Cond. latency score 26.9 1 1 33 0 1 Epha6
Pavlov. Cond. lever contacts 25.6 1 1 33 0 1 Epha6
Pavlov. Cond. magazine entry number 14.7 1 0 0 0 1 Epha6
Pavlov. Cond. lever-magazine prob. diff. 16.2 2 1 33 0 1 Epha6 Apeh
Pavlov. Cond. response bias 17.5 2 1 33 0 1 Epha6 Apeh
Bone surface 4.2 1 0 0 0 1 Epha6
Bone: cortical porosity 5.6 1 0 0 0 1 Epha6
Bone: cortical thickness 13.9 1 0 0 0 1 Epha6
Bone: maximum diameter 7.3 1 0 0 0 1 Epha6
Bone: periosteal estimation 3.0 1 0 0 0 1 Epha6
Bone: periosteal perimeter 4.9 1 0 0 0 1 Epha6
Bone: stiffness 7.8 1 0 0 0 1 Epha6
Time in open arm after self-admin 7.1 1 0 0 0 1 Tcp11l1
Time to tail flick, test, before self-admin 6.5 1 0 0 0 1 Epha6
Delta time to tail flick, vehicle, before/after SA 8.1 1 0 0 0 1 Epha6
Ambulatory time before self-admin 10.3 1 0 0 0 1 Apeh
Total heroin consumption 5.1 1 0 0 0 1 Epha6
Delay disc. indifference point, 0s delay 11.8 1 0 0 0 1 Epha6
Delay disc. indifference point, 4s delay 9.3 1 0 0 0 1 Epha6
Fecal boli incidents, locomotor time 1 6.7 1 0 0 0 1 Tcp11l1
Time >=10cm from walls, locomotor time 1 6.0 1 0 0 0 1 Epha6
Bouts of movement, locomotor time 1 7.9 1 0 0 0 1 Epha6
Rest time, locomotor task time 1 6.8 1 0 0 0 1 Tcp11l1
Rest time, locomotor task time 2 5.7 1 0 0 0 1 Epha6
Seeking ratio, delayed vs. immediate footshock 11.2 1 0 0 0 1 Epha6
Locomotion in novel chamber post-restriction 15.5 1 0 0 0 1 Epha6
Latency to leave start box in cocaine runway 10.3 1 0 0 0 1 Epha6
Cu content in liver 4.8 1 0 0 0 1 Apeh
Na content in liver 9.4 1 0 0 0 1 Epha6
Se content in liver 13.2 1 0 0 0 1 Epha6

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.1
Adipose alternative TSS 0 0.000 1.1
Adipose gene expression 0 0.000 1.1
Adipose isoform ratio 0 0.000 1.1
Adipose intron excision ratio 0 0.000 1.1
Adipose mRNA stability 0 0.000 1.1
BLA alternative polyA 0 0.000 1.1
BLA alternative TSS 0 0.000 1.0
BLA gene expression 0 0.000 1.1
BLA isoform ratio 0 0.000 1.2
BLA intron excision ratio 0 0.000 1.1
BLA mRNA stability 0 0.000 1.1
Brain alternative polyA 0 0.000 1.2
Brain alternative TSS 0 0.000 1.1
Brain gene expression 0 0.000 1.1
Brain isoform ratio 0 0.000 1.2
Brain intron excision ratio 0 0.000 1.1
Brain mRNA stability 0 0.000 1.1
Eye alternative polyA 0 0.000 1.8
Eye alternative TSS 0 0.000 1.1
Eye gene expression 0 0.000 1.1
Eye isoform ratio 0 0.000 1.2
Eye intron excision ratio 0 0.000 1.1
Eye mRNA stability 0 0.000 1.0
IL alternative polyA 0 0.000 1.3
IL alternative TSS 0 0.000 1.1
IL gene expression 0 0.000 1.1
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 0 0.000 1.1
IL mRNA stability 0 0.000 1.2
LHb alternative polyA 0 0.000 1.2
LHb alternative TSS 0 0.000 1.3
LHb gene expression 0 0.000 1.1
LHb isoform ratio 0 0.000 1.2
LHb intron excision ratio 0 0.000 1.1
LHb mRNA stability 0 0.000 1.2
Liver alternative polyA 0 0.000 1.2
Liver alternative TSS 0 0.000 1.2
Liver gene expression 0 0.000 1.1
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.1
Liver mRNA stability 0 0.000 1.1
NAcc alternative polyA 0 0.000 1.1
NAcc alternative TSS 0 0.000 1.1
NAcc gene expression 0 0.000 1.1
NAcc isoform ratio 0 0.000 1.1
NAcc intron excision ratio 0 0.000 1.1
NAcc mRNA stability 0 0.000 1.2
OFC alternative polyA 0 0.000 1.3
OFC alternative TSS 0 0.000 1.1
OFC gene expression 0 0.000 1.2
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.2
OFC mRNA stability 0 0.000 1.1
PL alternative polyA 0 0.000 1.2
PL alternative TSS 1 0.085 1.2
PL gene expression 0 0.000 1.1
PL isoform ratio 0 0.000 1.2
PL intron excision ratio 0 0.000 1.1
PL mRNA stability 2 0.069 1.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.