Pcsk2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Pcsk2	0.09	0.06	4.1e-13	0.11	0.12	0.1	0.11	1.0e-12	1.6e-13	4.0e-12	1.4e-12
2	pVTA	gene expression	Pcsk2	0.46	0.18	5.6e-17	0.33	0.36	0.32	0.38	4.5e-15	2.7e-16	1.4e-14	2.6e-17
3	pVTA	mRNA stability	Pcsk2	0.11	0.07	2.2e-06	0.15	0.14	0.13	0.12	5.3e-07	1.1e-06	3.7e-06	1.0e-05
4	PL	mRNA stability	Pcsk2	0.04	0.03	1.8e-05	0.03	0.01	0.03	-0	1.1e-04	3.3e-02	7.0e-04	5.0e-01
5	PL	gene expression	Pcsk2	0.09	0.05	1.7e-16	0.11	0.15	0.13	0.15	6.2e-12	2.6e-16	4.6e-14	4.3e-16
6	IL	gene expression	Pcsk2	0.5	0.22	1.1e-05	0.13	0.14	0.14	0.05	4.4e-04	2.4e-04	3.6e-04	2.7e-02
7	BLA	mRNA stability	Pcsk2	0.27	0.14	6.8e-09	0.09	-0	0.08	0.04	1.5e-05	8.9e-01	5.0e-05	3.9e-03
8	Brain	gene expression	Pcsk2	0.38	0.12	0.0e+00	0.46	0.45	0.46	0.35	9.8e-47	1.9e-45	1.0e-47	3.2e-33
9	OFC	gene expression	Pcsk2	0.56	0.16	1.1e-12	0.36	0.31	0.36	0.33	1.7e-09	4.6e-08	2.6e-09	1.5e-08
10	BLA	gene expression	Pcsk2	0.12	0.09	3.5e-04	0.02	0	0.02	0.02	3.5e-02	1.9e-01	2.3e-02	2.7e-02
11	Brain	mRNA stability	Pcsk2	0.19	0.1	3.3e-05	0.04	0.04	0.04	0.04	4.4e-05	2.9e-04	7.0e-05	6.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.1	0.2	0.5	-0.5	-0.4	-0.3	-0.1	-0.3	-0.5	-0.2	0.4	0.7	0.2	-0.3
Area under the delay curve	0.9	0.9	5.0	-0.3	-0.2	-0.4	-0.1	0.2	0.3	0.1	-0.4	-0.2	-2.2	-2.1
BMI with tail	10.5	34.1	42.6	6.4	6.3	6.1	6.2	6.3	6.5	6.0	-6.2	-6.5	-4.4	0.4
BMI without tail	9.1	18.9	24.8	5.0	4.9	4.8	4.7	4.7	4.8	4.3	-4.6	-4.6	-2.5	1.2
Body weight	12.8	53.5	67.5	8.2	8.2	8.0	8.0	8.0	8.0	8.0	-7.5	-7.6	-4.4	1.4
Weight adjusted by age	0.8	0.8	1.7	1.0	1.0	0.9	0.8	0.8	0.9	0.8	-0.8	-1.3	0.3	1.2
Bone surface	0.2	0.3	0.7	0.5	0.6	0.8	0.8	0.4	0.1	0.7	-0.2	-0.3	0.1	0.7
Bone volume	0.1	0.2	0.5	0.2	0.3	0.6	0.4	0.1	-0.2	0.3	0.0	0.2	0.5	0.7
Breakpoint value in progressive ratio session	0.4	0.5	0.7	0.8	0.8	0.8	0.8	0.6	0.6	0.8	-0.5	-0.5	-0.1	0.7
Number of licking bursts	0.1	0.2	1.0	-0.4	-0.4	-0.4	-0.3	-0.1	-0.1	0.2	0.0	0.2	-0.4	-1.0
Context. condit. distance diff. score	0.1	0.1	0.3	-0.3	-0.4	-0.2	-0.4	-0.4	-0.6	-0.3	0.3	0.6	0.2	0.1
Locomotion velocity, session 1	1.4	1.6	3.1	-1.2	-1.1	-1.0	-0.9	-1.5	-1.8	-0.6	1.6	1.3	1.2	1.1
Locomotion distance, session 1	4.9	6.2	8.8	-2.8	-2.8	-2.6	-2.5	-2.9	-3.0	-2.2	2.8	2.5	2.1	0.1
Locomotion velocity, session 2	2.1	2.5	3.8	-1.8	-1.8	-1.6	-1.5	-1.8	-1.9	-1.4	1.7	1.7	1.0	-0.6
Locomotion distance, session 2	6.0	8.5	11.2	-2.9	-3.0	-2.8	-3.0	-3.3	-3.4	-2.8	3.2	3.0	2.8	0.9
Locomotion velocity, session 3	3.8	4.4	5.6	-2.4	-2.3	-2.2	-2.1	-2.3	-2.3	-2.0	2.3	2.3	1.6	-0.4
Locomotion distance, session 3	1.4	1.5	2.3	-1.5	-1.5	-1.4	-1.4	-1.4	-1.3	-0.9	1.3	1.3	0.7	-0.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.7	0.3	0.3	0.3	0.2	0.1	0.2	-0.1	-0.1	0.1	0.9	0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.4	0.4	0.4	0.5	0.3	0.3	0.2	0.0	-0.2	-0.1	0.3	0.7
Locomotion velocity, session 7	1.7	1.8	3.7	-1.1	-1.1	-0.9	-1.3	-1.4	-1.6	-1.3	1.3	1.9	1.6	0.9
Locomotion distance, session 7	1.0	1.2	2.6	-0.6	-0.7	-0.4	-0.9	-1.0	-1.4	-0.7	1.0	1.6	1.4	1.5
Stereotopy head waving bouts, day 7	0.4	0.5	0.7	0.7	0.8	0.8	0.7	0.7	0.7	0.5	-0.7	-0.6	-0.7	0.1
Stereotopy head waving duration, day 7	0.0	0.1	0.3	-0.1	0.0	0.1	0.1	0.1	0.2	-0.1	-0.0	0.3	-0.4	-0.5
Locomotion velocity, session 8	1.4	1.6	2.8	-1.2	-1.1	-1.0	-1.0	-1.4	-1.7	-1.2	1.5	1.4	1.4	0.9
Locomotion distance, session 8	4.5	6.5	9.8	-2.5	-2.6	-2.3	-2.6	-2.9	-3.1	-2.5	2.7	2.8	2.5	0.8
Degree of sensitization distance	0.8	0.8	3.4	1.0	0.9	1.3	0.8	0.6	0.1	0.5	-0.4	0.1	0.4	1.8
Degree of sensitization stereotypy	0.7	0.8	1.7	0.8	0.9	0.9	1.0	0.9	0.8	0.8	-0.8	-0.7	-1.3	-0.4
Conditioned locomotion	0.3	0.4	1.5	-0.1	-0.0	0.0	-0.3	-0.3	-0.3	-0.3	0.3	0.8	1.2	1.2
Cocaine response after cond. corrected	2.2	2.5	4.2	-1.4	-1.4	-1.4	-1.7	-1.7	-1.7	-1.8	1.5	1.6	2.0	0.7
Cocaine response after cond. not corrected	3.4	3.7	6.1	-1.8	-1.8	-1.8	-2.2	-2.0	-1.9	-2.2	1.8	2.0	2.5	0.6
Cocaine response before conditioning	0.1	0.1	0.3	-0.4	-0.4	-0.3	-0.4	-0.3	-0.2	-0.2	0.2	0.5	0.3	-0.4
Saline control response	0.9	1.2	7.0	1.2	1.1	1.3	0.6	0.5	0.2	0.3	-0.3	-0.3	0.8	2.7
Bone: connectivity density	0.4	0.7	1.3	-1.0	-0.9	-0.8	-0.5	-0.8	-1.0	-0.7	1.0	1.1	0.6	-0.4
Bone: cortical apparent density	0.4	0.5	2.7	-0.6	-0.6	-0.9	-0.7	-0.2	0.1	-0.5	-0.1	-0.0	-0.7	-1.6
Bone: cortical area	0.4	0.6	1.0	0.8	0.8	0.6	0.7	0.9	1.0	0.5	-1.0	-0.8	-0.5	-0.4
Bone: cortical porosity	0.5	0.6	1.7	0.6	0.5	0.3	0.6	0.7	1.0	1.0	-0.8	-1.3	-0.5	-0.5
Bone: cortical porosity	0.8	0.9	1.8	0.9	0.8	0.6	0.9	1.0	1.2	1.2	-1.0	-1.4	-0.6	-0.4
Bone: cortical thickness	0.5	0.8	4.0	0.2	0.2	-0.1	0.2	0.8	1.1	0.3	-1.0	-0.7	-1.0	-2.0
Bone: cortical thickness	0.3	0.4	1.5	-0.9	-0.9	-0.8	-0.2	-0.4	-0.3	-0.1	0.5	0.5	-0.0	-1.2
Bone: cortical tissue density	0.3	0.4	2.0	-0.6	-0.6	-0.8	-0.6	-0.2	0.1	-0.4	-0.1	-0.0	-0.6	-1.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.0	-0.0	-0.1	-0.3	0.1	0.5	-0.1	-0.3	-0.3	0.1	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.0	-0.0	-0.1	-0.3	0.1	0.4	-0.0	-0.3	-0.2	0.1	-0.5
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.3	-0.1	0.2	-0.2	-0.1	-0.3	-0.1	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.4	0.2	0.1	0.2	0.2	-0.1	-0.2	0.1	0.1	-0.3	-0.0	0.7
Incentive salience index mean	0.3	0.4	1.7	-0.7	-0.7	-0.8	-0.8	-0.4	0.0	-0.6	0.1	0.0	-0.1	-1.3
Condit. Reinf. lever presses	0.5	0.6	4.3	-0.5	-0.5	-0.7	-0.5	-0.0	0.2	-0.2	-0.2	-0.3	-1.1	-2.1
Condit. Reinf. active minus inactive responses	0.5	0.6	1.9	1.0	0.9	1.2	0.2	0.5	0.4	0.5	-0.7	0.2	0.1	1.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.0	0.9	0.9	1.0	0.3	0.6	0.5	0.6	-0.8	-0.2	-0.3	0.8
Condit. Reinf. active responses	0.3	0.5	1.0	0.9	0.8	1.0	0.2	0.7	0.7	0.6	-1.0	-0.0	-0.8	0.1
Condit. Reinf. inactive responses	0.3	0.4	1.0	0.3	0.3	0.4	0.3	0.6	0.7	0.5	-0.7	-0.4	-1.0	-1.0
Condit. Reinf. lever presses	1.9	2.6	4.6	1.9	1.9	2.1	1.7	1.7	1.3	1.9	-1.6	-0.8	-1.2	0.9
Condit. Reinf. lever reinforcers received	0.4	0.6	1.3	1.0	0.9	1.2	0.2	0.8	0.7	0.6	-1.1	-0.2	-0.8	0.3
Conditioned reinforcement - actives	2.8	2.8	6.7	-1.4	-1.5	-1.5	-1.2	-1.9	-1.9	-1.6	2.0	1.1	2.6	1.3
Conditioned reinforcement - inactives	3.0	3.4	8.6	-1.3	-1.3	-1.8	-1.1	-2.0	-1.9	-2.0	2.2	1.0	2.9	2.0
Conditioned locomotion	2.5	3.0	4.3	-1.9	-2.1	-1.8	-1.7	-1.9	-2.0	-1.8	1.8	1.7	1.3	-0.4
Patch foraging indifference point 0 sec	1.0	1.6	7.1	-0.3	-0.2	-0.0	-0.3	-0.9	-1.1	-0.4	1.2	-0.0	2.6	2.7
Patch foraging indifference point AUC	1.4	1.7	3.0	-1.6	-1.7	-1.7	-1.3	-1.4	-1.3	-1.0	1.1	1.5	0.3	-0.5
Delay disc. indifference point, 0s delay	1.4	1.5	7.9	0.7	0.8	0.7	0.8	1.0	1.0	0.8	-1.2	-0.9	-2.8	-1.3
Delay disc. indifference point, 16s delay	1.1	1.1	2.8	-1.2	-1.1	-1.3	-1.1	-0.9	-0.7	-0.8	0.7	0.8	-0.5	-1.7
Delay disc. indifference point, 2s delay	1.7	1.9	7.1	1.0	1.0	1.0	0.9	1.3	1.2	1.0	-1.4	-1.3	-2.7	-1.5
Delay disc. indifference point, 24s delay	1.8	1.7	3.0	-1.6	-1.6	-1.7	-1.5	-1.2	-0.9	-1.3	0.9	0.9	-0.4	-1.7
Delay disc. indifference point, 4s delay	1.6	1.7	6.2	1.0	1.1	1.0	1.1	1.2	1.1	1.3	-1.3	-1.2	-2.5	-0.9
Delay disc. indifference point, 8s delay	0.7	0.8	2.7	-0.8	-0.8	-0.9	-0.8	-0.5	-0.3	-0.5	0.2	0.6	-1.4	-1.6
Indifference point function ln k	0.5	0.8	1.8	0.8	0.9	1.0	1.2	0.5	0.3	0.9	-0.1	-1.0	0.6	1.3
Indifference point function log k	0.5	0.8	1.8	0.8	0.9	1.0	1.2	0.5	0.3	0.9	-0.1	-1.0	0.6	1.3
Patch foraging total patch changes 0 sec	1.1	1.8	6.7	-0.6	-0.6	-0.4	-0.6	-1.2	-1.4	-0.6	1.4	0.3	2.6	2.4
Patch foraging total patch changes 12 sec	0.1	0.2	1.0	0.4	0.3	0.3	0.5	0.2	0.1	0.2	-0.2	-0.3	0.5	1.0
Patch foraging total patch changes 18 sec	2.0	2.5	3.3	-1.5	-1.4	-1.5	-1.7	-1.8	-1.8	-1.8	1.7	1.8	1.5	0.9
Patch foraging total patch changes 24 sec	0.7	0.9	1.2	-0.8	-0.9	-0.9	-1.0	-0.9	-1.0	-1.1	0.9	1.1	0.9	0.9
Patch foraging total patch changes 6 sec	0.4	0.5	1.2	-0.6	-0.7	-0.5	-0.6	-0.8	-0.7	-0.6	0.7	0.6	1.1	1.0
Patch foraging time to switch 0 sec	1.9	3.0	4.5	2.0	2.0	1.7	1.6	2.1	2.0	1.3	-2.1	-1.7	-1.4	-0.5
Patch foraging water rate 0 sec	2.2	3.5	5.0	-2.2	-2.2	-2.1	-1.9	-2.2	-2.0	-1.8	2.1	1.8	0.9	0.3
Patch foraging water rate 12 sec	3.3	5.0	7.4	-2.6	-2.6	-2.6	-2.5	-2.4	-2.0	-2.7	2.1	2.2	0.8	-1.1
Patch foraging water rate 18 sec	5.9	8.0	9.8	-3.0	-3.1	-3.0	-2.9	-3.1	-2.9	-3.0	3.1	2.6	2.9	0.7
Patch foraging water rate 24 sec	3.4	4.8	6.3	-2.2	-2.2	-2.3	-2.1	-2.5	-2.4	-2.4	2.4	2.3	1.9	0.7
Patch foraging water rate 6 sec	2.7	4.0	6.0	-2.2	-2.1	-2.3	-2.1	-2.1	-1.6	-2.3	2.1	2.5	1.5	-0.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.9	0.8	0.8	1.1	0.8	0.7	0.6	1.4	-0.5	-0.6	-0.4	0.9
Distance traveled before self-admin	0.5	0.5	0.9	0.7	0.8	0.5	0.9	0.7	0.7	0.6	-0.7	-0.7	-0.9	-0.2
Distance traveled after self-admin	0.7	0.8	3.5	-0.7	-0.7	-0.9	-0.6	-0.3	-0.2	-0.8	0.1	0.9	-1.3	-1.9
Extensor digitorum longus weight	0.4	1.7	2.9	1.5	1.5	1.5	1.7	1.3	1.3	1.6	-1.1	-0.9	-0.7	0.8
Bone: elastic displacement	0.2	0.2	0.4	0.3	0.2	0.3	0.5	0.5	0.5	0.6	-0.4	-0.1	-0.7	-0.3
Bone: elastic work	2.9	3.7	4.8	1.9	1.7	1.8	1.9	2.2	2.2	2.1	-2.2	-1.9	-2.2	-0.8
Bone: endosteal estimation	2.4	5.3	9.7	2.7	2.7	3.1	2.6	2.1	1.7	2.3	-1.9	-2.1	-0.4	2.4
Bone: endosteal perimeter	0.5	1.1	5.1	1.2	1.3	1.3	0.8	0.6	0.3	0.3	-0.5	-0.4	0.7	2.3
Epididymis fat weight	10.2	23.9	29.5	5.4	5.3	5.2	5.4	5.2	5.3	5.4	-4.8	-5.4	-3.2	1.3
Delta time in closed arm before/after self-admin	0.4	0.4	1.1	-0.6	-0.8	-0.0	-0.7	-0.6	-0.8	-0.4	0.7	1.1	0.7	0.2
Delta time in open arm before/after self-admin	1.3	1.3	1.8	1.3	1.3	0.9	1.3	1.2	1.3	1.2	-1.2	-1.1	-0.9	0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.5	-0.2	-0.1	-0.3	-0.1	-0.1	0.1	-0.4	-0.1	-0.1	-0.3	-0.7
Delay discount exponential model param	0.8	0.8	4.1	0.4	0.3	0.5	0.3	-0.0	-0.1	0.0	0.3	0.1	2.0	2.0
Extinction: sum of active levers before priming	0.3	0.3	1.1	0.3	0.3	0.4	0.4	0.1	0.1	0.7	0.1	-0.3	1.0	1.1
Active lever presses in extinction session 6	1.1	1.1	4.1	1.1	1.2	1.0	1.2	0.6	0.4	0.9	-0.3	-0.7	0.9	2.0
Bone: final force	0.9	1.5	2.2	1.3	1.3	1.4	1.1	1.4	1.4	1.2	-1.5	-1.2	-0.9	-0.4
Bone: final moment	0.8	1.3	1.8	1.2	1.2	1.3	1.1	1.3	1.3	1.2	-1.3	-1.1	-0.7	-0.2
Food consumed during 24 hour testing period	0.3	0.3	0.8	0.6	0.7	0.9	0.7	0.6	0.4	0.8	-0.4	-0.3	0.1	0.3
Glucose	2.1	3.1	5.1	2.1	2.1	2.3	1.9	1.7	1.7	2.1	-1.5	-1.2	-0.7	1.7
Heart weight	1.9	2.7	4.1	2.0	1.9	1.9	1.7	1.8	1.6	1.5	-1.6	-1.6	0.0	1.4
Delay discount hyperbolic model param	0.8	0.8	4.9	0.1	0.0	0.2	0.0	-0.3	-0.4	-0.2	0.5	0.3	2.2	1.9
Intermittent access intake day 1-15 change	0.4	0.4	3.1	0.5	0.3	0.4	0.3	-0.0	-0.1	0.1	0.2	-0.5	0.5	1.7
Intermittent access intake escalation	0.3	0.3	2.6	0.4	0.2	0.3	0.2	-0.1	-0.2	0.0	0.2	-0.4	0.5	1.6
Intermittent access intake escalation 2	1.0	1.0	2.6	1.2	1.1	0.7	1.1	0.6	0.8	0.5	-0.5	-1.5	0.4	1.6
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.9	0.6	0.5	0.4	0.9	0.5	0.6	0.3	-0.4	-0.7	0.1	0.4
Intermitt. access day 15 inactive lever presses	1.5	1.6	7.9	1.2	1.1	1.0	1.1	0.5	0.5	0.9	-0.1	-1.2	1.5	2.8
Intermitt. access escalation Index	1.2	1.0	2.1	1.2	1.0	1.4	1.1	1.0	0.7	1.3	-0.8	-0.8	-0.0	1.0
Intermittent access day 1 total infusions	0.1	0.2	0.6	0.3	0.2	0.6	0.4	0.3	0.1	0.4	-0.3	-0.5	0.8	0.0
Intermittent access day 15 total infusions	0.4	0.4	1.8	0.5	0.1	0.6	0.3	0.1	-0.2	0.3	0.1	-0.5	1.3	1.3
Intermittent access terminal intake (last 3 days)	0.4	0.4	1.2	0.7	0.4	0.7	0.5	0.4	0.2	0.5	-0.2	-0.8	1.1	1.0
Intermittent access total infusions	0.2	0.3	1.2	0.5	0.3	0.6	0.4	0.2	0.0	0.4	-0.1	-0.6	1.1	0.7
Intermittent access day 1 locomotion	0.1	0.1	1.3	-0.2	-0.3	-0.0	-0.1	0.0	-0.2	-0.0	-0.2	-0.1	0.2	-1.1
Intermittent access day 15 total locomotion	0.3	0.3	2.2	-0.3	-0.4	-0.4	-0.1	-0.4	-0.6	-0.2	0.5	0.0	1.5	0.2
Intermittent access total locomotion	0.6	0.7	1.0	-0.9	-1.0	-0.8	-0.9	-0.8	-1.0	-0.7	0.7	0.6	0.9	-0.9
Intermittent access standard deviation	0.4	0.4	1.5	-0.2	-0.2	-0.5	0.0	-0.5	-0.5	-0.5	0.6	-0.0	1.2	1.1
Left kidney weight	1.8	5.0	7.0	2.6	2.6	2.4	2.2	2.5	2.5	2.5	-2.3	-2.0	-1.2	1.0
Right kidney weight	1.5	4.1	5.7	2.4	2.3	2.2	2.3	2.3	2.2	2.3	-2.0	-1.8	-0.8	1.1
Cocaine induced anxiety	0.3	0.3	0.5	-0.4	-0.5	-0.3	-0.5	-0.7	-0.7	-0.5	0.7	0.6	-0.3	0.7
Post-drug Anxiety	1.9	2.1	4.4	1.6	1.4	2.1	1.3	1.2	1.0	1.6	-1.0	-1.5	-1.6	1.5
Baseline Anxiety	5.1	5.4	7.8	2.5	2.5	2.6	2.7	2.4	2.3	2.5	-2.1	-2.8	-0.8	1.5
Tail length	0.7	2.2	3.9	1.8	1.9	1.7	1.9	1.3	1.3	1.3	-1.0	-0.9	0.9	2.0
Length with tail	2.2	8.0	11.8	3.3	3.4	3.2	3.4	3.0	3.0	3.1	-2.6	-2.4	-0.5	1.6
Length without tail	1.7	3.8	5.9	2.1	2.2	2.1	2.1	2.2	2.1	2.4	-1.9	-2.1	-1.0	0.2
Times rat made contact with spout	1.5	1.7	2.9	1.6	1.6	1.7	1.7	1.4	0.9	1.4	-1.1	-0.7	-0.9	1.0
Lifetime Intake	0.2	0.2	1.5	-0.1	-0.3	0.1	-0.1	-0.3	-0.6	-0.1	0.4	-0.0	1.2	0.6
Liver weight, left	0.2	0.4	0.6	0.6	0.7	0.7	0.8	0.7	0.8	0.8	-0.6	0.1	-0.3	0.2
Liver weight, right	0.3	0.6	1.0	0.8	0.9	0.8	0.8	0.9	1.0	0.6	-0.9	-0.4	0.4	-0.1
Locomotor activity	0.3	0.5	0.8	0.8	0.7	0.9	0.6	0.7	0.8	0.9	-0.7	-0.6	-0.4	0.4
Locomotor testing distance	0.1	0.2	0.3	-0.5	-0.6	-0.4	-0.5	-0.5	-0.4	-0.2	0.4	0.5	-0.0	0.1
Locomotor testing rearing	0.1	0.2	0.9	-0.5	-0.4	-0.5	-0.4	-0.4	-0.4	-0.5	0.4	0.9	0.1	-0.2
Locomotion in novel chamber	0.7	0.9	3.6	-0.6	-0.7	-0.5	-0.5	-0.9	-0.9	-0.5	1.0	0.3	1.9	1.2
Locomotion in novel chamber post-restriction	2.0	2.4	3.5	-1.8	-1.9	-1.5	-1.5	-1.6	-1.7	-1.2	1.7	1.9	1.0	-0.6
Fecal boli incidents, locomotor time 1	0.4	0.5	1.9	-0.4	-0.2	0.1	-0.2	-0.7	-0.9	-0.3	0.9	0.8	0.5	1.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.3	-0.4	-0.6	-0.6	-0.2	-0.0	-0.2	0.1	0.1	0.6	-0.6
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.4	-0.3	-0.6	-0.5	-0.4	-0.3	-0.5	0.4	0.5	0.6	-0.1
Bouts of movement, locomotor time 1	0.8	0.9	1.5	-1.0	-0.7	-0.9	-0.6	-1.1	-1.2	-1.0	1.2	1.2	0.7	0.5
Total resting periods, locomotor time 1	1.3	1.4	2.2	-1.2	-0.9	-1.1	-0.8	-1.4	-1.4	-1.2	1.5	1.4	1.3	0.8
Rest time, locomotor task time 1	0.7	0.8	2.0	-0.6	-0.5	-0.3	-0.5	-0.7	-0.9	-0.6	0.8	1.4	1.4	1.1
Distance moved, locomotor task time 1	1.0	1.1	5.7	-0.9	-1.0	-1.4	-1.1	-0.5	-0.1	-1.1	0.2	-0.0	-0.7	-2.4
Vertical activity count, locomotor time 1	0.6	0.6	2.1	0.5	0.5	0.1	0.4	0.7	0.8	0.5	-0.7	-0.9	-1.0	-1.4
Time >=10cm from walls, locomotor time 2	1.8	1.9	2.7	1.6	1.6	1.5	1.4	1.5	1.4	1.7	-1.4	-1.3	-0.8	0.3
Bouts of movement, locomotor time 2	0.3	0.3	1.2	0.4	0.5	0.4	0.4	0.5	0.4	0.0	-0.7	-0.2	-1.1	-0.4
Total resting periods, locomotor time 2	0.3	0.4	1.2	0.6	0.6	0.5	0.6	0.5	0.5	0.1	-0.8	-0.4	-1.1	-0.2
Rest time, locomotor task time 2	0.1	0.1	0.7	0.3	0.4	0.4	0.5	0.0	-0.0	0.3	0.0	0.0	-0.0	0.9
Distance moved, locomotor task time 2	1.1	1.3	2.1	-1.2	-1.3	-1.4	-1.4	-0.9	-0.7	-1.4	0.8	1.0	0.2	-1.4
Vertical activity count, locomotor time 2	0.4	0.4	2.8	-0.4	-0.5	-0.5	-0.6	-0.1	-0.1	-0.4	-0.0	0.4	-0.3	-1.7
Light reinforcement 1	0.5	0.8	2.4	-0.5	-0.3	-0.6	-0.2	-0.9	-1.1	-0.5	1.2	0.7	1.4	1.6
Light reinforcement 2	0.6	0.7	3.5	-0.3	-0.4	-0.3	-0.1	-0.8	-1.0	-0.3	1.2	0.3	1.1	1.9
Bone: marrow area	2.4	5.1	9.5	2.7	2.7	3.1	2.5	2.1	1.6	2.3	-1.9	-2.0	-0.3	2.5
Bone: maximum diameter	0.7	1.2	2.4	1.4	1.4	1.4	1.4	1.0	0.6	1.1	-0.8	-0.7	0.1	1.5
Bone: maximum force	0.7	1.2	1.8	1.2	1.2	1.2	0.8	1.3	1.3	1.1	-1.4	-1.1	-0.6	-0.3
Bone: maximum moment	0.7	1.2	1.8	1.2	1.1	1.2	0.9	1.3	1.3	1.1	-1.3	-1.1	-0.5	-0.3
Mean time between licks in bursts	0.3	0.4	0.8	-0.8	-0.7	-0.7	-0.6	-0.5	-0.4	-0.5	0.6	0.9	0.7	-0.7
Mean num. licks in bursts	1.0	1.2	3.1	1.3	1.3	1.4	1.3	0.9	0.6	0.6	-0.6	-0.6	0.1	1.8
Cd content in liver	0.5	0.5	1.0	0.6	0.7	0.8	0.7	0.9	0.8	1.0	-0.8	-0.4	-0.5	-0.8
Co content in liver	1.0	1.1	1.6	-1.3	-1.2	-1.3	-1.0	-0.9	-1.0	-1.0	1.0	1.1	0.8	-1.1
Cu content in liver	0.3	0.4	1.1	-0.5	-0.5	-0.4	-0.6	-0.6	-0.6	-0.4	0.7	1.0	0.7	0.4
Fe content in liver	0.3	0.4	1.1	0.8	0.7	0.5	0.1	0.8	1.1	0.5	-1.0	0.1	-0.3	-0.1
K content in liver	1.6	1.6	5.3	-1.4	-1.4	-1.6	-1.2	-0.8	-0.5	-1.1	0.6	0.8	-1.1	-2.3
Mg content in liver	0.6	0.6	3.1	-0.5	-0.6	-0.8	-0.7	-0.1	0.2	-0.7	-0.1	0.0	-1.1	-1.8
Mn content in liver	2.2	2.5	3.7	-1.5	-1.5	-1.3	-1.7	-1.7	-1.7	-1.9	1.7	1.6	1.6	0.8
Na content in liver	0.7	0.8	5.4	-0.5	-0.5	-0.8	-0.4	0.0	0.1	0.0	-0.2	0.2	-1.3	-2.3
Rb content in liver	0.8	1.0	3.3	0.4	0.3	0.1	0.4	0.8	1.2	0.3	-1.1	-1.0	-1.8	-1.7
Se content in liver	0.4	0.4	1.2	0.4	0.4	0.0	0.5	0.7	1.1	0.7	-0.7	-0.6	-0.6	-0.9
Sr content in liver	1.0	0.9	1.6	-0.8	-0.8	-0.6	-0.9	-1.0	-1.2	-0.6	1.0	1.3	1.2	0.4
Zn content in liver	0.3	0.4	1.0	-0.6	-0.6	-0.8	-0.6	-0.3	-0.2	-0.5	0.4	0.9	0.3	-1.0
Bone: minimum diameter	0.5	1.0	1.7	1.3	1.3	1.3	0.9	1.1	1.0	0.8	-1.2	-1.0	-0.2	0.5
Time in familiar zone, hab. session 1	0.2	0.2	1.1	0.1	0.2	0.1	0.4	0.4	0.4	0.5	-0.3	-0.0	-0.8	-1.1
Time in novel zone, hab. session 1	0.2	0.2	0.8	0.6	0.5	0.6	0.3	0.2	0.3	0.2	-0.4	-0.6	0.0	0.9
Total zone transitions, hab. session 1	1.1	1.5	3.0	-1.3	-1.3	-1.1	-1.0	-1.4	-1.5	-0.9	1.5	1.7	0.9	0.3
Total locomotion distance, hab. session 1	1.4	2.0	3.0	-1.6	-1.6	-1.4	-1.4	-1.6	-1.6	-1.2	1.5	1.7	1.2	0.2
Locomotion velocity, hab. session 1	2.3	3.2	4.8	-2.0	-2.0	-1.9	-1.9	-2.0	-1.9	-1.6	1.9	2.2	1.3	-0.1
Time in familiar zone, hab. session 2	0.6	0.6	1.1	-0.7	-0.8	-0.9	-0.8	-0.8	-0.7	-1.1	0.8	0.6	0.7	0.2
Time in novel zone, hab. session 2	1.4	1.4	2.3	1.3	1.3	1.4	1.3	1.2	1.1	1.5	-1.2	-0.9	-0.8	0.5
Total zone transitions, hab. session 2	0.3	0.3	1.2	-0.3	-0.3	-0.1	-0.4	-0.6	-0.8	-0.3	0.7	0.4	0.8	1.1
Total locomotion distance, hab. session 2	1.3	1.8	3.2	-1.0	-1.1	-0.7	-1.2	-1.5	-1.6	-1.0	1.4	1.3	1.8	1.6
Locomotion velocity, hab. session 2	2.1	2.8	4.2	-1.5	-1.6	-1.2	-1.6	-1.9	-2.0	-1.4	1.9	1.7	2.0	1.3
Novel to familiar place preference ratio	0.1	0.1	0.4	0.1	0.1	0.2	0.0	0.1	0.1	0.6	-0.2	-0.1	-0.3	-0.0
Novelty place preference	0.1	0.1	0.5	0.1	0.1	0.1	0.1	0.2	0.2	0.7	-0.2	-0.2	-0.4	-0.4
Time in novel zone, NPP test	0.3	0.3	1.0	0.5	0.5	0.5	0.4	0.5	0.5	1.0	-0.5	-0.4	-0.5	-0.1
Total zone transitions, NPP test	1.0	1.4	2.2	-1.3	-1.4	-1.1	-1.4	-1.4	-1.5	-1.0	1.3	1.3	0.8	0.2
Total locomotion distance, NPP test	2.5	3.4	5.5	-1.8	-1.9	-1.5	-2.0	-2.2	-2.3	-1.5	2.0	1.8	1.8	1.1
Locomotion velocity, NPP test	3.2	4.5	6.8	-2.2	-2.3	-1.8	-2.4	-2.5	-2.6	-1.8	2.3	2.0	1.9	0.8
Intraocular pressure	0.3	0.4	1.6	-0.3	-0.3	0.2	-0.3	-0.5	-0.6	0.2	0.6	0.2	1.3	1.1
Delta distance traveled before/after self-admin	1.4	1.5	5.7	-1.2	-1.2	-1.3	-1.3	-0.6	-0.5	-1.2	0.3	1.1	-1.2	-2.4
Delta ambulatory time before/after self-admin	1.0	1.0	2.6	-1.1	-1.1	-1.1	-1.2	-0.6	-0.6	-1.0	0.4	1.2	-0.7	-1.6
Parametrial fat weight	17.1	33.4	43.6	6.4	6.4	6.2	6.6	6.2	6.0	6.4	-5.8	-5.8	-4.2	1.5
Pavlov. Cond. lever latency	1.1	1.4	6.8	1.4	1.3	1.5	0.9	0.7	0.4	0.6	-0.5	-0.4	0.9	2.6
Pavlov. Cond. magazine entry latency	1.2	1.6	4.5	0.6	0.7	0.4	0.8	1.0	1.5	1.2	-1.2	-1.5	-2.1	-1.7
Pavlov. Cond. change in total contacts	1.4	1.5	9.6	-1.1	-1.0	-1.3	-0.9	-0.3	0.3	-0.7	-0.1	-0.1	-1.3	-3.1
Pavlov. Cond. index score	1.0	1.3	8.4	-0.5	-0.5	-0.7	-0.2	0.2	0.7	0.0	-0.5	-0.7	-1.8	-2.9
Pavlov. Cond. latency score	1.1	1.4	8.8	-1.1	-1.0	-1.2	-0.8	-0.3	0.1	-0.5	0.0	-0.2	-1.4	-3.0
Pavlov. Cond. lever contacts	0.6	0.7	5.0	-0.7	-0.6	-0.8	-0.4	-0.1	0.1	-0.2	-0.2	-0.2	-1.1	-2.2
Pavlov. Cond. magazine entry number	1.8	2.2	4.8	-0.9	-1.0	-0.7	-1.0	-1.4	-1.8	-1.3	1.6	1.8	2.2	1.8
Pavlov. Cond. intertrial magazine entries	2.8	3.4	8.5	-1.0	-1.1	-0.9	-1.5	-1.7	-1.8	-1.9	1.9	1.9	2.9	2.6
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	9.6	-0.4	-0.4	-0.6	-0.1	0.3	0.8	0.1	-0.7	-0.8	-2.0	-3.1
Pavlov. Cond. response bias	1.2	1.5	5.0	0.4	0.5	0.2	0.5	0.9	1.4	0.8	-1.2	-1.4	-1.9	-2.2
Pavlov. Cond. lever latency	3.4	4.6	7.1	-2.6	-2.5	-2.7	-2.2	-2.4	-2.0	-2.3	2.3	1.5	1.6	-0.8
Pavlov. Cond. magazine entry latency	1.9	2.2	5.7	1.7	1.7	1.9	1.7	1.2	0.7	1.7	-0.9	-0.8	-0.0	2.4
Pavlov. Cond. change in total contacts	3.5	4.8	6.8	2.6	2.5	2.6	2.0	2.4	2.2	2.3	-2.5	-1.8	-1.8	0.5
Pavlov. Cond. index score	3.7	4.8	7.3	2.6	2.6	2.7	2.3	2.3	1.9	2.5	-2.2	-1.7	-1.3	1.2
Pavlov. Cond. latency score	2.6	3.2	5.0	2.1	2.1	2.2	1.9	1.9	1.5	2.0	-1.9	-1.4	-1.1	1.0
Pavlov. Cond. lever contacts	3.0	4.0	5.9	2.4	2.3	2.4	2.0	2.2	1.9	2.2	-2.2	-1.7	-1.5	0.6
Pavlov. Cond. magazine entry number	2.6	3.2	5.1	-2.2	-2.1	-2.3	-2.0	-1.7	-1.3	-2.0	1.5	1.3	0.6	-1.8
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.6	-1.2	-1.2	-1.4	-1.4	-0.9	-0.5	-1.4	0.6	0.7	0.4	-1.6
Pavlov. Cond. lever-magazine prob. diff.	4.2	5.4	7.6	2.7	2.7	2.8	2.4	2.5	2.1	2.6	-2.4	-1.9	-1.6	0.9
Pavlov. Cond. response bias	3.3	4.5	7.5	2.6	2.5	2.7	2.2	2.2	1.8	2.5	-2.1	-1.6	-1.2	1.5
Time in closed arm before self-admin	0.2	0.2	1.4	0.0	-0.0	0.1	-0.0	-0.2	-0.4	-0.0	0.3	-0.2	0.6	1.2
Time in closed arm after self-admin	2.2	2.2	4.9	-1.2	-1.4	-0.6	-1.4	-1.5	-1.9	-1.1	1.6	1.5	2.2	1.4
Time in open arm before self-admin	0.3	0.4	2.9	-0.0	0.1	-0.3	0.1	0.2	0.6	-0.3	-0.4	-0.2	-0.5	-1.7
Time in open arm after self-admin	1.5	1.7	3.7	1.1	1.2	0.6	1.2	1.4	1.7	0.8	-1.5	-1.0	-1.9	-1.3
Bone: periosteal estimation	1.6	3.3	5.4	2.2	2.2	2.3	2.0	1.8	1.6	1.7	-1.8	-1.8	-0.4	1.4
Bone: periosteal perimeter	0.2	0.4	1.4	0.8	0.8	0.7	0.4	0.4	0.2	0.1	-0.4	0.1	0.5	1.2
Bone: post-yield work	0.2	0.3	0.6	0.6	0.6	0.6	0.2	0.5	0.7	0.1	-0.5	-0.8	0.4	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.6	-0.2	-0.3	-0.0	-0.2	-0.2	-0.5	0.1	0.2	0.1	0.8	-0.2
Progressive ratio test 1 breakpoint	0.0	0.1	0.2	-0.0	-0.2	0.2	-0.0	-0.0	-0.3	0.2	-0.1	-0.1	0.5	-0.4
Progressive ratio test 1 inactive lever presses	0.4	0.4	2.1	-0.1	-0.2	-0.0	0.1	-0.5	-0.7	-0.1	0.7	0.2	1.2	1.5
Progressive ratio test 2 active lever presses	0.2	0.2	1.2	-0.1	-0.3	-0.2	-0.2	-0.3	-0.3	-0.5	0.2	-0.2	1.1	0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	0.1	-0.1	0.1	-0.0	-0.1	-0.1	-0.2	-0.1	-0.4	0.7	-0.1
Progressive ratio test 2 inactive lever presses	0.7	0.8	3.3	0.7	0.6	0.6	0.8	0.1	-0.0	0.4	0.1	-0.9	1.6	1.8
Incentive Sensitization - Responses	0.4	0.4	1.9	-0.2	-0.4	-0.4	-0.4	-0.4	-0.4	-0.9	0.4	-0.0	1.4	0.5
Incentive Sensitization - Breakpoint	0.4	0.4	1.8	-0.3	-0.4	-0.4	-0.5	-0.5	-0.5	-1.0	0.5	0.1	1.3	0.5
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.3	-0.8	-0.8	-0.9	-0.6	-1.0	-1.0	-0.5	1.2	0.9	0.8	0.8
Progressive ratio	2.3	2.6	3.8	-1.8	-1.7	-1.6	-1.6	-1.8	-2.0	-1.3	1.9	1.6	1.5	0.6
Food seeking constrained by brief footshock	4.1	5.0	7.3	-2.6	-2.4	-2.7	-2.6	-2.2	-2.2	-2.4	1.9	2.5	0.6	-1.7
Seeking ratio, punishment vs. effort	0.7	0.8	2.6	0.6	0.6	0.4	0.4	0.9	0.9	0.2	-1.1	-0.5	-1.5	-1.6
Retroperitoneal fat weight	20.5	67.2	82.4	9.0	8.9	8.8	9.1	8.9	8.7	8.9	-8.6	-8.2	-6.4	1.2
Reaction time number correct	0.3	0.5	1.0	-0.6	-0.5	-0.6	-0.6	-0.8	-0.6	-0.9	0.8	0.6	1.0	0.3
Reaction time mean minus median	1.9	2.5	4.3	1.8	1.9	1.9	2.0	1.6	1.3	2.1	-1.2	-1.3	-0.9	0.9
Reaction time mean minus median AUC	1.6	2.0	4.0	1.6	1.7	1.7	2.0	1.4	1.1	2.0	-0.9	-1.0	-0.5	0.9
Reaction time num false alarms	2.1	2.8	4.0	-1.7	-1.8	-1.5	-1.7	-1.8	-2.0	-1.3	1.8	1.9	2.0	0.5
Reaction time num false alarms AUC	1.8	2.5	3.4	-1.7	-1.8	-1.4	-1.7	-1.7	-1.8	-1.3	1.7	1.7	1.6	0.3
Reaction time trials correct on left	0.3	0.5	1.0	-0.6	-0.5	-0.6	-0.6	-0.8	-0.6	-0.9	0.8	0.6	1.0	0.3
Reaction time trials on left	0.3	0.4	1.0	-0.5	-0.5	-0.6	-0.5	-0.8	-0.6	-0.8	0.8	0.6	1.0	0.4
Reaction time mean	2.9	4.0	5.7	2.4	2.3	2.3	2.3	2.1	1.9	2.3	-1.9	-1.6	-1.4	0.9
Reaction time mean AUC	2.8	3.7	5.1	2.3	2.2	2.2	2.3	2.1	1.8	2.2	-1.8	-1.6	-1.3	0.8
Median of all reaction times	2.3	3.2	4.6	2.2	2.0	2.0	2.0	1.9	1.7	2.0	-1.8	-1.4	-1.4	0.8
Reaction time omissions	0.6	0.9	1.8	1.0	1.0	1.2	1.3	1.0	0.8	1.3	-0.7	-0.7	-0.5	0.2
Reaction time false alarm rate	1.1	1.5	2.3	-1.3	-1.4	-1.1	-1.3	-1.3	-1.5	-0.8	1.3	1.4	1.2	0.2
Reaction time premature initiation rate	0.5	0.7	3.3	-0.2	-0.3	-0.2	0.0	-0.5	-0.6	-0.3	0.7	-0.0	1.8	1.6
Reaction time premature initiations	0.8	1.2	5.0	-0.5	-0.5	-0.5	-0.2	-0.9	-1.0	-0.7	1.1	0.4	2.2	1.7
Std. dev. reaction times	2.4	3.3	5.2	2.1	2.0	2.1	2.2	1.9	1.7	2.3	-1.6	-1.5	-1.5	0.7
Reaction time trials completed	0.3	0.4	1.0	-0.5	-0.5	-0.6	-0.5	-0.8	-0.6	-0.8	0.8	0.6	1.0	0.4
Reaction time trials AUC	0.3	0.4	1.0	-0.4	-0.3	-0.5	-0.4	-0.7	-0.5	-0.8	0.7	0.5	1.0	0.7
Run reversals in cocaine runway, females	1.5	1.5	2.5	1.2	1.3	1.3	1.3	1.2	1.0	1.2	-1.3	-1.4	-1.6	-0.1
Run reversals in cocaine runway, males	1.3	1.2	2.6	1.1	1.0	1.0	0.7	1.2	1.2	0.9	-1.4	-0.7	-1.6	-0.9
Latency to leave start box in cocaine runway	0.1	0.1	0.8	0.2	-0.1	0.3	-0.0	0.1	0.1	0.4	0.0	-0.1	0.9	0.6
Latency to leave start box in cocaine runway, F	0.6	0.7	1.7	1.0	0.6	1.1	0.7	0.7	0.6	1.0	-0.5	-0.6	0.7	1.3
Latency to leave start box in cocaine runway, M	1.0	1.0	1.6	-1.2	-1.3	-1.1	-1.2	-1.0	-0.8	-1.0	0.8	0.7	0.8	-0.9
Std. dev. time between licks in bursts	0.8	1.0	1.6	-1.2	-1.2	-1.1	-1.0	-1.0	-1.0	-0.6	1.1	1.3	0.6	-0.6
Total sessions with >9 infusions	0.4	0.4	1.1	-0.5	-0.7	-0.2	-0.8	-0.6	-1.0	-0.2	0.6	0.4	1.1	-0.1
Short access day 1 total inactive lever presses	0.8	0.9	3.5	-0.3	-0.4	0.1	-0.2	-0.8	-0.9	-0.1	1.1	0.4	1.9	1.8
Short access day 10 total inactive lever presses	1.7	1.9	3.7	1.6	1.5	1.3	1.9	1.3	1.5	1.4	-1.1	-1.5	-0.6	1.1
Short access day 1 total infusions	1.8	1.9	3.1	-1.3	-1.5	-1.0	-1.3	-1.5	-1.8	-0.9	1.6	1.3	1.7	0.7
Short access day 10 total infusions	0.2	0.3	0.8	-0.3	-0.6	0.1	-0.5	-0.5	-0.9	-0.1	0.5	0.5	0.7	0.4
Short access total infusions	0.2	0.2	0.6	-0.4	-0.6	-0.1	-0.4	-0.5	-0.8	-0.2	0.5	0.2	0.7	-0.0
Short access day 1 locomotion	0.8	0.8	1.8	-0.9	-1.0	-0.6	-1.1	-1.0	-1.3	-0.4	0.9	1.1	0.8	-0.1
Short access day 10 total locomotion	0.8	0.9	1.9	-1.1	-1.2	-1.0	-0.9	-1.1	-1.4	-0.7	0.9	0.9	0.4	-0.5
Short access total locomotion	1.2	1.2	1.8	-1.3	-1.3	-1.1	-1.2	-1.1	-1.3	-1.1	0.9	1.0	0.4	-1.2
One hour access (0.3 mA shock)	1.4	1.7	2.4	-1.4	-1.5	-1.4	-1.2	-1.5	-1.5	-1.5	1.4	1.1	1.0	-0.1
Compulsive drug intake	1.1	1.1	1.8	-1.2	-1.1	-1.2	-0.8	-1.2	-1.0	-0.9	1.3	1.3	1.0	0.1
One hour access (shock baseline)	0.1	0.1	0.3	0.3	0.1	0.4	0.2	0.2	0.1	0.1	-0.2	-0.6	0.4	-0.0
Social response proportion	7.1	7.7	10.4	3.0	3.0	3.2	3.2	3.0	2.9	2.8	-2.8	-2.8	-2.0	0.8
Social responses	0.4	0.6	1.3	0.8	0.9	1.1	0.8	0.8	0.5	0.8	-0.8	-0.4	-0.4	0.6
Social time	1.5	2.0	3.3	1.4	1.5	1.8	1.7	1.6	1.1	1.8	-1.3	-0.9	-1.4	-0.4
Soleus weight	0.2	0.6	1.1	0.8	0.8	1.0	1.0	0.8	0.7	1.0	-0.6	0.2	-0.3	0.6
Bone: stiffness	0.2	0.3	0.6	0.7	0.7	0.8	0.3	0.6	0.6	0.6	-0.7	-0.5	0.1	0.1
Tibialis anterior weight	1.5	5.2	7.6	2.5	2.5	2.4	2.3	2.5	2.8	2.3	-2.5	-2.4	-1.6	0.2
Time to tail flick, vehicle, before self-admin	4.4	4.5	7.0	2.4	2.5	2.1	2.5	1.8	2.0	2.1	-1.5	-2.4	0.6	2.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.2	0.2	0.2	0.3	0.1	0.4	0.3	-0.2	-0.6	-0.5	0.2
Time to tail flick, test, before self-admin	0.2	0.2	0.5	-0.3	-0.2	-0.6	-0.3	-0.5	-0.2	-0.6	0.5	0.2	0.7	0.5
Time to tail flick, test, after self-admin	1.0	1.1	6.5	-0.1	-0.1	-0.3	-0.1	-0.8	-0.8	-0.2	1.1	-0.3	1.6	2.5
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.4	-1.4	-1.5	-1.2	-1.5	-1.3	-1.3	-1.2	1.1	1.4	-0.1	-0.8
Delta time to tail flick, test, before/after SA	0.3	0.3	1.9	0.0	-0.0	0.1	0.0	-0.3	-0.5	0.0	0.5	-0.3	0.5	1.4
Tibia length	3.1	8.8	12.5	3.5	3.5	3.5	3.2	3.3	3.2	3.3	-3.1	-2.5	-1.2	0.9
Ambulatory time before self-admin	0.4	0.4	1.0	0.7	0.7	0.4	0.8	0.6	0.6	0.6	-0.6	-0.7	-1.0	0.0
Ambulatory time after self-admin	1.0	1.0	3.4	-1.0	-0.9	-1.0	-0.9	-0.5	-0.5	-0.9	0.3	1.1	-1.3	-1.8
Bone: tissue strength	0.6	0.6	1.1	0.9	0.9	0.9	0.5	1.0	0.9	0.8	-1.0	-0.4	-0.7	-0.3
Total heroin consumption	0.5	0.6	2.6	-0.2	-0.1	-0.4	0.1	-0.6	-0.5	-0.4	0.8	0.1	1.5	1.6
Bone: trabecular number	0.3	0.5	1.5	-0.8	-0.7	-0.7	-0.5	-0.6	-0.7	-0.5	0.7	1.2	0.5	-0.5
Bone: trabecular spacing	1.6	2.0	2.7	1.6	1.5	1.6	1.3	1.5	1.5	1.3	-1.6	-1.7	-1.5	0.2
Bone: trabecular thickness	0.0	0.1	0.2	-0.2	-0.1	-0.3	0.3	0.1	0.1	0.1	0.2	-0.2	0.2	-0.4
Bone: trabecular tissue density	0.4	0.6	1.8	0.4	0.3	0.1	0.1	0.7	1.0	0.6	-1.0	-1.0	-0.9	-1.3
Water consumed over 24 hours	0.4	0.5	3.1	0.5	0.5	0.7	0.5	0.1	-0.2	0.1	0.2	0.1	0.9	1.8
Number of responses in last shaping day	1.9	2.0	4.8	-1.1	-1.1	-1.3	-1.1	-1.5	-1.6	-1.2	1.6	1.4	2.2	1.1