Hub : Genes

Pcsk2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Pcsk2 0.08 0.04 1.1e-16 0.15 0.15 0.16 0.16 8.8e-16 4.4e-16 3.7e-17 1.3e-16
2 pVTA mRNA stability Pcsk2 0.13 0.06 4.9e-11 0.14 0.14 0.14 0.14 2.3e-11 1.4e-11 1.6e-11 1.3e-11
3 IC gene expression Pcsk2 0.24 0.1 4.2e-14 0.3 0.29 0.25 0.3 6.8e-13 1.2e-12 5.3e-11 3.6e-13
4 OFC gene expression Pcsk2 0.64 0.16 7.3e-12 0.35 0.31 0.34 0.36 3.5e-09 4.7e-08 5.1e-09 1.7e-09
5 NAcc gene expression Pcsk2 0.08 0.04 0.0e+00 0.1 0.12 0.11 0.11 2.0e-14 2.0e-17 1.8e-16 6.6e-16
6 BLA mRNA stability Pcsk2 0.3 0.15 4.8e-09 0.12 -0 0.1 0.02 9.2e-07 9.4e-01 9.3e-06 3.9e-02
7 Brain gene expression Pcsk2 0.47 0.13 0.0e+00 0.47 0.41 0.46 0.44 2.3e-49 6.0e-41 1.6e-47 6.2e-45
8 IC mRNA stability Pcsk2 0.17 0.09 6.1e-07 0.14 0.14 0.11 0.13 1.4e-06 2.1e-06 2.2e-05 3.3e-06
9 PL mRNA stability Pcsk2 0.04 0.03 3.0e-05 0.04 0.03 0.03 0.01 6.7e-05 3.6e-04 1.9e-04 2.8e-02
10 pVTA gene expression Pcsk2 0.47 0 0.0e+00 0.26 0.28 0.28 0.28 9.4e-21 5.8e-23 5.0e-23 1.7e-22
11 IL gene expression Pcsk2 0.34 0.22 4.4e-05 0.12 0.16 0.11 0.12 6.5e-04 8.9e-05 1.6e-03 7.2e-04
12 BLA gene expression Pcsk2 0.1 0.07 1.8e-04 0.06 0.04 0.01 0.04 3.2e-04 6.1e-03 8.0e-02 3.8e-03
13 Brain mRNA stability Pcsk2 0.17 0.09 1.3e-04 0.05 0.04 0.05 0.05 2.5e-05 2.2e-04 1.7e-05 1.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.50.20.4-0.3-0.2-0.40.00.7-0.2-0.20.4-0.3-0.10.5
Area under the delay curve0.30.44.50.20.5-0.30.6-0.3-0.2-0.1-0.1-0.2-0.00.3-0.52.1
BMI with tail12.945.158.7-7.7-6.97.17.37.07.1-6.87.06.7-6.56.9-6.8-0.3
BMI without tail6.233.041.5-6.4-6.06.16.26.15.9-6.25.75.8-5.85.9-5.5-0.7
Body weight16.070.290.0-9.5-8.88.98.78.88.8-8.88.78.8-8.58.5-7.9-1.7
Weight adjusted by age0.10.30.9-0.5-0.50.60.20.50.6-0.60.10.5-0.50.5-0.2-1.0
Bone surface0.20.30.9-0.4-0.70.70.50.50.9-0.10.80.8-0.50.3-0.4-0.5
Bone volume0.10.10.3-0.1-0.50.30.10.20.60.20.40.4-0.2-0.1-0.2-0.4
Breakpoint value in progressive ratio session0.10.10.2-0.4-0.30.40.40.40.4-0.30.40.5-0.30.3-0.3-0.3
Number of licking bursts0.10.21.5-0.10.3-0.2-0.1-0.20.20.40.3-0.1-0.1-0.1-0.21.2
Context. condit. distance diff. score0.10.10.30.40.3-0.3-0.3-0.3-0.10.4-0.3-0.40.4-0.60.3-0.1
Locomotion velocity, session 11.51.63.01.61.0-1.3-1.7-1.3-0.81.7-0.8-0.90.7-1.71.3-1.0
Locomotion distance, session 15.46.99.73.12.6-2.8-2.9-2.8-2.33.0-2.3-2.52.6-2.92.7-0.3
Locomotion velocity, session 22.32.73.91.91.6-1.8-1.8-1.8-1.62.0-1.6-1.61.4-1.81.60.1
Locomotion distance, session 26.59.113.73.72.8-3.1-3.5-3.1-2.83.1-2.8-3.02.7-3.43.3-1.2
Locomotion velocity, session 34.04.66.12.42.2-2.3-2.5-2.4-1.82.5-1.9-2.12.1-2.32.00.3
Locomotion distance, session 31.31.52.11.41.2-1.4-1.5-1.4-0.61.5-0.7-1.31.2-1.31.00.8
Stereotopy head waving bouts, day 30.00.10.4-0.1-0.10.2-0.00.2-0.2-0.3-0.10.2-0.20.1-0.1-0.6
Stereotopy head waving duration, day 30.10.10.2-0.3-0.40.40.20.3-0.1-0.40.00.3-0.30.2-0.3-0.5
Locomotion velocity, session 71.51.73.11.50.9-1.3-1.5-1.2-1.21.3-1.2-1.40.9-1.81.1-1.1
Locomotion distance, session 70.81.02.91.10.3-0.8-1.2-0.7-0.61.0-0.6-0.90.5-1.50.8-1.7
Stereotopy head waving bouts, day 70.50.61.2-1.0-0.70.80.80.80.4-1.10.60.9-0.81.0-0.80.4
Stereotopy head waving duration, day 70.10.10.4-0.3-0.00.10.10.0-0.1-0.30.00.3-0.00.3-0.20.6
Locomotion velocity, session 81.41.72.51.61.0-1.2-1.5-1.2-1.11.5-1.3-1.01.1-1.61.2-1.3
Locomotion distance, session 84.66.69.53.12.3-2.6-3.0-2.6-2.32.8-2.5-2.62.4-3.12.6-1.0
Degree of sensitization distance0.80.94.4-0.6-1.20.90.61.00.5-0.70.60.8-1.10.2-0.6-2.1
Degree of sensitization stereotypy0.70.81.2-1.1-0.80.90.90.80.7-0.90.81.1-0.90.9-0.90.4
Conditioned locomotion0.10.21.10.0-0.40.0-0.30.1-0.2-0.3-0.10.0-0.8-0.2-0.0-1.1
Cocaine response after cond. corrected1.92.83.81.91.6-1.6-1.8-1.6-1.91.5-1.8-1.81.5-1.81.9-0.5
Cocaine response after cond. not corrected2.73.95.02.21.9-2.0-2.1-1.9-2.21.8-2.1-2.21.8-2.12.1-0.3
Cocaine response before conditioning0.10.10.30.20.3-0.4-0.3-0.30.00.3-0.1-0.40.4-0.1-0.10.5
Saline control response0.70.98.3-0.3-1.10.7-0.00.80.4-0.60.30.4-0.7-0.2-0.2-2.9
Bone: connectivity density0.40.61.70.80.9-0.7-0.8-0.9-0.41.3-0.6-0.50.9-0.80.50.5
Bone: cortical apparent density0.30.52.00.41.0-0.7-0.2-0.6-0.40.4-0.4-0.60.8-0.10.61.4
Bone: cortical area0.30.50.8-0.8-0.50.70.90.70.7-0.80.60.5-0.50.9-0.60.5
Bone: cortical porosity0.50.51.0-0.9-0.30.60.70.50.8-0.71.00.5-0.41.0-0.80.7
Bone: cortical porosity0.80.91.6-1.1-0.70.90.90.91.1-1.01.30.8-0.81.1-1.00.3
Bone: cortical thickness0.40.74.5-0.80.30.30.90.30.4-0.70.30.10.01.0-0.92.1
Bone: cortical thickness0.30.42.30.30.7-0.4-0.3-0.60.21.00.10.00.6-0.1-0.01.5
Bone: cortical tissue density0.30.41.50.50.9-0.7-0.2-0.6-0.40.4-0.4-0.60.8-0.10.71.2
Condit. Reinf. active minus inactive responses0.10.10.4-0.10.2-0.00.10.00.0-0.60.0-0.30.00.4-0.10.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.10.00.00.20.10.1-0.60.1-0.30.00.4-0.20.3
Condit. Reinf. active responses0.10.10.20.20.4-0.3-0.2-0.2-0.2-0.3-0.2-0.40.10.10.20.3
Condit. Reinf. inactive responses0.00.10.40.10.0-0.0-0.30.0-0.10.0-0.00.2-0.3-0.20.3-0.6
Incentive salience index mean0.30.41.70.40.9-0.7-0.3-0.6-0.50.0-0.5-0.90.6-0.00.21.3
Condit. Reinf. lever presses0.40.54.80.10.8-0.50.1-0.5-0.50.1-0.5-0.60.40.2-0.12.2
Condit. Reinf. active minus inactive responses0.60.92.4-0.9-1.10.80.61.00.4-1.30.50.3-1.40.4-0.7-1.6
Condit. Reinf. active-inactive response ratio0.40.61.3-0.8-0.90.80.60.90.4-1.00.50.3-1.10.5-0.7-1.1
Condit. Reinf. active responses0.50.81.7-1.0-1.00.81.01.00.6-1.30.60.3-1.10.8-1.0-0.4
Condit. Reinf. inactive responses0.30.51.1-0.7-0.50.40.90.50.8-0.60.60.4-0.30.8-0.91.1
Condit. Reinf. lever presses2.33.44.6-2.0-2.21.91.71.92.0-1.61.91.7-2.01.3-2.1-1.2
Condit. Reinf. lever reinforcers received0.60.91.9-1.1-1.10.81.01.00.6-1.40.60.3-1.20.7-1.1-0.5
Conditioned reinforcement - actives1.04.16.92.51.4-1.5-2.6-1.6-1.72.6-1.6-1.32.1-2.42.3-2.2
Conditioned reinforcement - inactives1.33.47.72.11.3-1.1-2.2-1.3-1.62.3-1.6-0.91.6-1.82.5-2.8
Conditioned locomotion2.53.75.02.21.9-2.1-2.1-1.9-2.02.2-1.9-1.82.1-2.11.50.3
Patch foraging indifference point 0 sec0.41.28.11.30.1-0.3-0.9-0.5-0.41.0-0.4-0.40.8-1.11.2-2.8
Patch foraging indifference point AUC0.71.83.01.21.7-1.6-1.2-1.6-1.11.5-1.1-1.41.5-1.20.81.1
Delay disc. indifference point, 0s delay0.91.03.1-0.7-0.50.71.30.70.5-1.10.60.7-1.01.1-1.41.8
Delay disc. indifference point, 16s delay0.71.02.30.91.3-1.1-0.7-1.1-1.10.8-1.0-1.10.9-0.60.61.5
Delay disc. indifference point, 2s delay1.41.53.1-0.9-1.01.11.61.11.0-1.21.01.1-1.41.3-1.81.4
Delay disc. indifference point, 24s delay1.01.62.51.21.6-1.4-0.8-1.4-1.40.9-1.3-1.21.4-0.80.81.5
Delay disc. indifference point, 4s delay1.11.12.2-0.8-0.80.91.50.90.9-1.01.01.0-1.01.1-1.41.3
Delay disc. indifference point, 8s delay0.30.42.30.80.8-0.70.1-0.7-0.50.2-0.5-0.70.4-0.20.31.5
Indifference point function ln k0.31.02.3-0.5-1.21.00.50.91.2-0.41.21.4-1.00.5-0.5-1.5
Indifference point function log k0.31.02.3-0.5-1.21.00.50.91.2-0.41.21.4-1.00.5-0.5-1.5
Patch foraging total patch changes 0 sec0.51.56.71.60.5-0.6-1.2-0.8-0.61.3-0.6-0.71.1-1.41.5-2.6
Patch foraging total patch changes 12 sec0.10.11.0-0.1-0.30.30.30.30.2-0.10.10.30.00.0-0.0-1.0
Patch foraging total patch changes 18 sec1.12.63.41.91.5-1.6-1.8-1.6-1.61.5-1.7-1.71.5-1.81.7-1.0
Patch foraging total patch changes 24 sec0.20.81.21.00.9-0.9-0.9-0.8-1.00.5-1.0-1.10.8-1.00.7-1.0
Patch foraging total patch changes 6 sec0.40.71.21.10.7-0.7-0.6-0.7-0.70.8-0.8-0.81.1-0.80.9-1.0
Patch foraging time to switch 0 sec0.83.25.3-2.2-1.81.92.12.01.4-2.31.51.5-1.72.0-1.60.5
Patch foraging water rate 0 sec1.14.05.32.32.2-2.1-2.3-2.2-1.92.1-1.9-1.81.9-2.02.0-0.3
Patch foraging water rate 12 sec1.45.57.12.52.6-2.6-2.3-2.5-2.52.2-2.6-2.42.7-2.02.21.1
Patch foraging water rate 18 sec4.08.912.13.43.1-3.1-3.4-3.1-2.83.0-3.1-2.73.0-3.03.5-0.9
Patch foraging water rate 24 sec3.75.27.82.62.4-2.2-2.8-2.4-2.22.2-2.4-2.12.0-2.42.6-0.9
Patch foraging water rate 6 sec2.74.05.42.32.3-2.2-2.3-2.2-2.11.6-2.2-1.91.9-1.62.30.2
Seeking ratio, delayed vs. immediate footshock0.60.81.9-0.6-1.10.90.50.81.3-0.31.40.9-0.90.5-0.7-1.2
Distance traveled before self-admin0.40.92.0-0.6-0.60.91.10.90.8-1.30.81.2-1.41.1-0.80.6
Distance traveled after self-admin0.40.62.60.51.1-0.9-0.4-0.7-0.90.3-0.9-0.60.5-0.30.51.6
Extensor digitorum longus weight0.41.73.1-1.2-1.51.41.21.31.8-1.01.61.6-1.31.2-0.8-0.8
Bone: elastic displacement0.30.40.9-0.7-0.50.50.80.60.7-0.50.70.5-0.50.7-0.90.5
Bone: elastic work3.54.56.7-2.4-1.92.02.62.12.4-2.12.21.9-1.82.3-2.51.1
Bone: endosteal estimation2.45.810.4-2.0-3.22.62.12.62.5-2.02.52.8-2.81.6-1.5-2.4
Bone: endosteal perimeter0.41.05.8-0.4-1.31.00.31.00.3-0.90.30.7-1.20.2-0.0-2.4
Epididymis fat weight9.246.456.8-7.5-7.27.16.87.07.5-7.17.56.9-6.96.6-6.6-1.7
Delta time in closed arm before/after self-admin0.20.21.00.4-0.0-0.4-0.4-0.4-0.01.0-0.1-0.60.7-0.60.20.2
Delta time in open arm before/after self-admin1.41.72.9-1.5-1.11.31.11.41.2-1.71.21.5-1.41.4-1.1-0.6
Diff in mean of infusions in LGA sessions0.20.42.1-0.30.10.20.90.3-0.1-0.8-0.20.1-0.00.8-0.61.5
Delay discount exponential model param0.30.44.0-0.4-0.60.4-0.40.40.4-0.10.30.4-0.2-0.10.3-2.0
Extinction: sum of active levers before priming0.10.10.50.50.1-0.3-0.2-0.20.20.30.2-0.00.3-0.30.4-0.7
Active lever presses in extinction session 60.90.91.5-0.9-0.91.20.81.11.1-0.51.11.2-1.10.7-0.7-1.1
Bone: final force0.81.21.9-1.1-1.21.11.21.11.4-1.21.20.9-1.11.2-1.10.3
Bone: final moment0.61.01.7-0.9-1.21.01.11.01.3-1.01.10.9-0.91.0-1.00.1
Food consumed during 24 hour testing period0.10.30.7-0.5-0.70.60.50.60.8-0.30.70.6-0.30.4-0.1-0.3
Glucose2.23.54.8-1.8-2.21.91.51.92.1-2.02.11.8-2.01.6-1.5-1.7
Heart weight1.52.45.0-1.6-1.61.71.41.81.3-2.21.21.6-1.41.3-1.1-1.5
Delay discount hyperbolic model param0.30.43.40.0-0.20.0-0.70.0-0.00.2-0.1-0.00.2-0.40.6-1.9
Intermittent access intake day 1-15 change0.00.21.7-0.2-0.40.50.20.50.4-0.10.30.4-0.1-0.0-0.3-1.3
Intermittent access intake escalation0.00.11.40.0-0.20.30.00.40.2-0.10.00.3-0.0-0.2-0.2-1.2
Intermittent access intake escalation 20.20.40.8-0.6-0.30.80.40.80.6-0.90.50.8-0.60.6-0.3-0.8
Intermitt. access day 1 inactive lever presses0.00.51.3-0.5-0.60.70.40.60.7-0.50.81.1-0.30.60.3-1.2
Intermitt. access day 15 inactive lever presses0.21.311.60.1-0.70.8-0.30.60.80.50.80.80.3-0.10.9-3.4
Intermitt. access escalation Index0.20.71.3-0.9-1.10.81.10.90.9-0.50.90.7-0.80.8-1.00.0
Intermittent access day 1 total infusions0.00.10.4-0.2-0.60.50.30.40.2-0.00.40.40.10.2-0.1-0.3
Intermittent access day 15 total infusions0.20.42.0-0.2-0.90.70.40.70.6-0.10.60.5-0.00.1-0.4-1.4
Intermittent access terminal intake (last 3 days)0.40.71.6-0.6-1.11.00.71.00.8-0.40.90.8-0.40.4-0.6-1.3
Intermittent access total infusions0.20.31.0-0.3-0.70.70.40.60.4-0.10.50.6-0.10.2-0.1-1.0
Intermittent access day 1 locomotion0.20.31.00.50.4-0.5-0.4-0.5-0.60.7-0.3-0.40.5-0.40.31.0
Intermittent access day 15 total locomotion0.10.31.10.60.4-0.4-0.7-0.4-0.31.0-0.2-0.30.7-0.80.3-0.3
Intermittent access total locomotion0.91.11.71.21.0-1.1-1.1-1.0-1.11.3-0.9-1.11.2-1.20.80.6
Intermittent access standard deviation0.10.40.90.90.7-0.5-0.6-0.5-0.60.5-0.6-0.20.6-0.70.7-0.8
Left kidney weight1.07.79.8-3.1-3.02.92.92.93.1-3.03.12.7-2.72.7-2.4-1.2
Right kidney weight0.42.84.8-1.6-1.81.81.61.81.8-2.21.61.8-1.71.8-1.0-1.2
Cocaine induced anxiety0.10.10.30.50.3-0.4-0.4-0.3-0.30.3-0.4-0.30.5-0.30.5-0.0
Post-drug Anxiety1.72.02.4-1.5-1.51.41.51.41.6-1.31.51.4-1.41.4-1.5-0.3
Baseline Anxiety3.76.27.9-2.8-2.52.42.72.52.5-2.52.72.5-2.72.4-2.7-0.5
Tail length0.52.73.7-1.7-1.91.71.51.71.6-1.81.51.9-1.91.4-1.3-1.2
Length with tail3.214.118.2-4.1-4.14.03.54.03.8-4.03.74.3-4.03.5-3.1-2.1
Length without tail2.010.313.7-3.7-3.33.53.13.33.5-3.23.63.4-3.23.2-2.9-1.1
Times rat made contact with spout1.92.23.3-1.5-1.71.71.41.61.7-1.11.51.6-1.81.0-1.4-1.0
Lifetime Intake0.10.10.70.2-0.30.2-0.10.10.10.40.20.20.3-0.20.3-0.9
Liver weight, left2.84.86.8-2.3-2.62.42.42.42.2-2.12.12.3-2.11.9-1.9-1.3
Liver weight, right3.66.39.5-2.5-3.12.62.52.62.7-2.32.72.5-2.82.2-2.4-1.6
Locomotor activity0.40.60.8-0.9-0.80.70.80.70.7-0.80.70.7-0.80.7-0.9-0.5
Locomotor testing distance0.10.10.40.40.6-0.4-0.3-0.5-0.40.3-0.3-0.40.3-0.30.30.1
Locomotor testing rearing0.00.10.40.20.6-0.4-0.4-0.5-0.50.3-0.4-0.40.2-0.30.40.1
Locomotion in novel chamber1.01.31.91.01.0-1.2-1.3-1.3-0.91.4-1.0-1.11.4-1.31.1-0.4
Locomotion in novel chamber post-restriction1.02.94.91.11.6-2.0-2.2-2.0-1.42.1-1.4-1.71.9-1.91.50.4
Fecal boli incidents, locomotor time 10.20.52.51.10.1-0.4-0.7-0.5-0.10.8-0.4-0.1-0.0-0.90.6-1.6
Change in fecal boli incidents, locomotor task0.30.31.0-0.50.5-0.5-0.7-0.4-0.60.1-0.3-0.81.0-0.20.60.2
Time >=10cm from walls, locomotor time 10.10.20.40.10.4-0.4-0.7-0.4-0.6-0.3-0.5-0.30.2-0.10.50.1
Bouts of movement, locomotor time 10.70.91.61.30.9-0.8-1.0-1.0-0.71.3-0.9-0.30.4-1.11.2-0.6
Total resting periods, locomotor time 11.21.42.51.51.1-1.1-1.3-1.2-0.91.6-1.0-0.50.7-1.31.5-0.9
Rest time, locomotor task time 10.30.53.30.50.3-0.3-0.9-0.4-0.20.7-0.3-0.20.1-0.70.9-1.8
Distance moved, locomotor task time 10.41.36.40.61.2-1.0-0.3-0.9-1.30.3-1.1-1.11.4-0.20.42.5
Vertical activity count, locomotor time 10.10.42.2-0.6-0.30.40.70.50.1-0.60.30.4-0.00.7-0.61.5
Time >=10cm from walls, locomotor time 20.82.44.6-2.1-1.61.60.91.61.6-1.81.71.7-1.41.5-1.5-0.5
Bouts of movement, locomotor time 20.00.10.6-0.1-0.20.30.60.30.0-0.50.30.2-0.80.3-0.20.3
Total resting periods, locomotor time 20.00.20.8-0.1-0.30.40.60.40.1-0.50.30.3-0.90.4-0.20.1
Rest time, locomotor task time 20.10.21.30.3-0.20.40.10.20.30.10.20.2-0.70.00.2-1.1
Distance moved, locomotor task time 20.81.12.80.51.1-1.3-0.8-1.1-1.20.4-1.0-1.11.3-0.70.51.7
Vertical activity count, locomotor time 20.10.32.2-0.00.3-0.50.0-0.3-0.5-0.5-0.3-0.40.30.0-0.11.5
Light reinforcement 10.10.71.90.80.6-0.4-1.2-0.6-0.50.9-0.5-0.30.5-1.11.1-1.4
Light reinforcement 20.30.73.10.80.3-0.2-1.3-0.5-0.00.9-0.2-0.10.7-1.00.9-1.8
Bone: marrow area2.35.610.1-2.0-3.22.62.02.52.5-1.92.42.7-2.81.6-1.4-2.5
Bone: maximum diameter0.61.12.1-0.9-1.31.30.61.21.1-0.71.11.2-1.30.5-0.5-1.4
Bone: maximum force0.61.11.7-1.0-1.11.01.21.01.3-1.31.10.7-0.91.2-1.00.3
Bone: maximum moment0.51.01.6-1.0-1.01.01.21.01.3-1.21.10.8-0.81.2-1.00.2
Mean time between licks in bursts0.10.40.80.60.7-0.6-0.3-0.7-0.50.5-0.4-0.60.9-0.40.80.8
Mean num. licks in bursts0.41.23.8-0.7-1.31.20.81.20.9-1.00.71.2-1.10.6-0.7-1.9
Cd content in liver0.40.51.6-0.5-0.80.40.60.50.8-0.30.90.5-0.70.4-1.2-0.2
Co content in liver0.50.60.90.90.5-0.7-0.8-0.7-0.50.9-0.6-0.70.8-0.90.8-0.6
Cu content in liver0.10.10.20.40.3-0.3-0.3-0.3-0.10.4-0.1-0.20.2-0.30.5-0.4
Fe content in liver1.82.24.5-1.8-1.11.42.01.50.8-2.11.30.9-1.11.9-1.50.7
K content in liver1.41.44.70.71.5-1.2-0.5-1.2-1.10.9-1.1-1.21.5-0.30.52.2
Mg content in liver0.10.10.7-0.30.10.00.50.1-0.1-0.5-0.2-0.30.30.4-0.30.8
Mn content in liver1.82.03.51.80.8-1.2-1.5-1.1-1.31.1-1.6-1.31.3-1.61.9-1.5
Na content in liver0.40.44.3-0.30.6-0.10.3-0.20.10.30.3-0.10.20.3-0.32.1
Rb content in liver1.01.22.1-1.2-0.91.01.51.01.1-1.11.01.1-1.01.3-1.10.6
Se content in liver1.01.12.4-1.3-0.61.11.31.01.0-1.31.00.9-0.91.5-0.70.8
Sr content in liver1.41.21.81.30.8-1.0-1.2-1.0-1.01.3-1.3-1.11.0-1.30.9-0.8
Zn content in liver0.20.31.00.10.7-0.40.0-0.4-0.4-0.2-0.5-0.80.80.10.21.0
Bone: minimum diameter0.50.91.4-0.9-1.11.11.11.10.8-1.20.70.8-1.10.9-0.6-0.5
Time in familiar zone, hab. session 10.20.21.2-0.4-0.30.20.50.20.3-0.10.40.4-0.40.5-0.61.1
Time in novel zone, hab. session 10.20.20.7-0.4-0.50.50.30.50.2-0.60.50.4-0.40.3-0.3-0.8
Total zone transitions, hab. session 11.01.42.51.41.1-1.2-1.6-1.3-0.81.5-0.7-0.91.1-1.41.2-0.3
Total locomotion distance, hab. session 11.42.02.81.61.4-1.6-1.7-1.6-1.31.5-1.2-1.41.5-1.51.5-0.1
Locomotion velocity, hab. session 12.33.34.22.01.9-2.0-2.0-2.0-1.71.9-1.7-1.81.9-1.91.90.1
Time in familiar zone, hab. session 20.50.50.90.90.6-0.8-1.0-0.7-1.00.6-0.9-0.70.4-0.80.60.0
Time in novel zone, hab. session 21.41.52.1-1.4-1.21.31.41.31.5-1.11.41.2-1.01.1-1.0-0.8
Total zone transitions, hab. session 20.20.30.90.60.3-0.4-0.8-0.4-0.10.5-0.3-0.30.0-0.80.7-1.0
Total locomotion distance, hab. session 21.21.62.81.60.8-1.2-1.5-1.1-0.81.2-1.0-1.20.7-1.71.5-1.4
Locomotion velocity, hab. session 22.02.74.32.01.3-1.7-2.0-1.6-1.21.7-1.4-1.71.2-2.11.9-1.1
Novel to familiar place preference ratio0.00.00.2-0.1-0.10.0-0.00.10.3-0.20.40.00.00.0-0.1-0.4
Novelty place preference0.00.00.2-0.2-0.10.10.10.10.3-0.20.50.1-0.00.2-0.2-0.1
Time in novel zone, NPP test0.20.30.7-0.6-0.50.50.50.50.6-0.60.80.5-0.40.5-0.5-0.3
Total zone transitions, NPP test1.11.72.41.51.2-1.4-1.5-1.3-1.11.4-1.1-1.41.2-1.51.3-0.1
Total locomotion distance, NPP test2.63.65.52.31.5-1.9-2.3-1.9-1.62.0-1.6-2.01.9-2.42.0-1.1
Locomotion velocity, NPP test3.44.87.02.61.9-2.3-2.6-2.2-1.92.3-1.9-2.42.2-2.62.3-0.8
Intraocular pressure0.20.31.50.6-0.4-0.3-0.5-0.3-0.10.50.1-0.30.5-0.60.0-1.2
Delta distance traveled before/after self-admin2.73.04.01.22.0-1.9-1.5-1.7-1.91.6-2.0-2.02.0-1.51.31.6
Delta ambulatory time before/after self-admin1.32.23.11.11.7-1.7-1.4-1.5-1.61.4-1.7-1.71.8-1.31.11.1
Parametrial fat weight26.261.878.8-8.9-8.18.27.88.28.7-7.78.68.5-8.27.6-7.4-1.6
Pavlov. Cond. lever latency1.31.77.9-0.8-1.71.30.51.31.1-1.11.11.3-1.20.5-0.5-2.8
Pavlov. Cond. magazine entry latency1.01.32.7-1.3-0.40.81.30.80.8-1.31.00.9-1.01.6-1.31.6
Pavlov. Cond. change in total contacts1.11.28.70.31.4-0.90.0-0.9-0.90.3-0.8-1.00.90.30.03.0
Pavlov. Cond. index score0.70.99.0-0.30.9-0.40.5-0.4-0.3-0.1-0.2-0.30.30.7-0.53.0
Pavlov. Cond. latency score1.01.29.50.31.4-0.9-0.1-0.9-0.80.5-0.7-0.90.80.2-0.03.1
Pavlov. Cond. lever contacts0.50.65.70.00.9-0.50.2-0.6-0.40.3-0.4-0.50.30.2-0.12.4
Pavlov. Cond. magazine entry number1.21.63.61.40.5-0.8-1.4-0.9-0.91.4-1.1-0.81.1-1.71.5-1.9
Pavlov. Cond. intertrial magazine entries2.42.95.82.11.0-1.2-2.0-1.1-1.61.1-1.8-1.51.3-1.92.3-2.4
Pavlov. Cond. lever-magazine prob. diff.0.91.110.6-0.50.8-0.20.7-0.2-0.1-0.3-0.1-0.20.20.9-0.73.3
Pavlov. Cond. response bias0.91.25.3-1.2-0.10.51.30.60.6-1.10.60.5-0.71.5-1.12.3
Pavlov. Cond. lever latency3.55.06.62.62.5-2.4-2.3-2.4-2.42.2-2.2-2.02.5-1.92.40.8
Pavlov. Cond. magazine entry latency2.23.15.9-1.4-2.11.81.21.72.1-1.12.11.9-1.90.8-1.4-2.4
Pavlov. Cond. change in total contacts2.45.87.8-2.7-2.72.52.62.72.3-2.82.32.0-2.82.1-2.4-0.7
Pavlov. Cond. index score3.65.77.7-2.6-2.82.52.32.52.6-2.22.62.3-2.71.8-2.4-1.4
Pavlov. Cond. latency score2.64.25.7-2.2-2.42.22.02.22.3-1.82.22.0-2.41.6-2.1-1.1
Pavlov. Cond. lever contacts3.65.37.0-2.6-2.62.42.42.52.5-2.32.32.1-2.51.9-2.4-0.9
Pavlov. Cond. magazine entry number2.93.75.21.82.3-2.0-1.7-2.0-2.21.6-2.1-2.02.3-1.21.71.9
Pavlov. Cond. intertrial magazine entries0.81.62.81.01.5-1.3-0.7-1.2-1.70.6-1.7-1.61.5-0.50.91.5
Pavlov. Cond. lever-magazine prob. diff.4.26.58.3-2.8-2.92.72.52.72.8-2.42.72.5-2.82.1-2.7-1.1
Pavlov. Cond. response bias4.56.28.7-2.6-3.02.62.32.62.7-2.32.72.3-2.81.8-2.4-2.0
Time in closed arm before self-admin0.10.20.9-0.5-0.50.50.30.40.3-0.30.30.4-0.70.1-0.2-0.9
Time in closed arm after self-admin0.50.61.60.50.2-0.6-0.9-0.7-0.41.3-0.4-0.80.7-1.20.7-0.9
Time in open arm before self-admin0.20.21.40.30.5-0.4-0.4-0.4-0.50.2-0.6-0.40.40.00.21.2
Time in open arm after self-admin0.60.61.9-0.9-0.30.60.60.70.4-1.40.40.7-0.71.2-0.81.0
Bone: periosteal estimation1.43.45.4-1.7-2.32.01.82.02.0-1.71.92.0-2.11.5-1.3-1.4
Bone: periosteal perimeter0.20.42.3-0.3-0.60.50.10.60.0-0.7-0.00.2-0.90.10.0-1.5
Bone: post-yield work0.10.10.6-0.1-0.20.20.10.3-0.1-0.8-0.10.0-0.30.30.2-0.6
Progressive ratio test 1 active lever presses0.10.10.2-0.1-0.40.40.10.30.30.40.30.4-0.00.00.2-0.4
Progressive ratio test 1 breakpoint0.10.10.3-0.2-0.50.50.20.40.50.30.50.5-0.20.10.1-0.4
Progressive ratio test 1 inactive lever presses0.20.63.70.5-0.20.2-0.7-0.10.31.10.50.30.4-0.61.0-1.9
Progressive ratio test 2 active lever presses0.10.10.50.30.10.1-0.20.0-0.20.4-0.30.00.4-0.30.3-0.7
Progressive ratio test 2 breakpoint0.10.10.60.40.10.0-0.3-0.0-0.30.4-0.30.00.4-0.30.4-0.7
Progressive ratio test 2 inactive lever presses0.20.74.0-0.2-0.80.9-0.00.70.80.40.91.0-0.3-0.00.2-2.0
Incentive Sensitization - Responses0.10.41.00.70.5-0.3-0.6-0.3-0.80.4-0.7-0.40.8-0.60.6-1.0
Incentive Sensitization - Breakpoint0.20.41.10.70.5-0.3-0.7-0.3-0.80.5-0.8-0.40.8-0.60.6-1.0
Sum of active levers in priming session hrs 5-60.30.30.50.60.7-0.5-0.5-0.5-0.20.7-0.3-0.30.6-0.60.7-0.6
Progressive ratio1.02.84.21.51.4-1.5-2.0-1.7-1.42.1-1.2-1.51.9-2.01.7-1.7
Food seeking constrained by brief footshock4.35.47.72.42.8-2.5-2.1-2.5-2.52.3-2.4-2.52.3-2.32.21.0
Seeking ratio, punishment vs. effort0.20.53.3-0.4-0.20.40.90.50.2-0.60.00.3-0.80.8-0.71.8
Retroperitoneal fat weight29.3131.1169.6-13.0-11.812.212.112.012.2-11.512.012.2-11.311.5-10.8-1.9
Reaction time number correct0.20.61.80.70.8-0.6-1.0-0.7-0.80.7-0.9-0.40.5-0.71.3-0.6
Reaction time mean minus median0.42.64.9-1.6-1.61.71.01.62.0-1.32.21.9-1.91.3-1.1-1.2
Reaction time mean minus median AUC0.32.24.8-1.4-1.51.70.81.52.1-0.72.21.9-1.71.0-1.0-1.1
Reaction time num false alarms1.72.94.22.01.5-1.7-1.8-1.7-1.62.0-1.6-1.71.6-2.01.6-0.5
Reaction time num false alarms AUC1.12.64.11.91.5-1.7-1.6-1.7-1.42.0-1.6-1.71.6-1.91.4-0.2
Reaction time trials correct on left0.20.61.80.70.8-0.6-1.0-0.7-0.80.7-0.9-0.40.5-0.71.3-0.6
Reaction time trials on left0.20.51.60.70.7-0.6-1.0-0.6-0.70.7-0.8-0.30.4-0.61.3-0.7
Reaction time mean2.04.45.7-2.3-2.22.31.92.32.3-1.92.42.2-2.31.8-2.0-1.1
Reaction time mean AUC1.74.05.3-2.2-2.12.21.92.22.2-1.82.32.1-2.21.7-1.9-1.0
Median of all reaction times2.33.54.7-2.2-2.02.11.92.12.0-1.72.01.9-2.01.6-1.9-0.8
Reaction time omissions0.91.42.3-1.2-1.31.31.01.11.5-0.61.51.4-1.40.9-1.1-0.5
Reaction time false alarm rate1.11.52.51.51.0-1.3-1.1-1.3-1.11.6-1.1-1.41.2-1.50.80.2
Reaction time premature initiation rate0.30.42.20.70.4-0.3-0.6-0.3-0.30.8-0.4-0.10.5-0.70.9-1.5
Reaction time premature initiations0.31.03.01.00.8-0.6-1.1-0.7-0.71.2-0.8-0.30.6-1.11.5-1.7
Std. dev. reaction times1.13.65.8-2.0-1.92.01.61.92.3-1.62.42.0-2.11.6-1.7-1.0
Reaction time trials completed0.20.51.60.70.7-0.6-1.0-0.6-0.70.7-0.8-0.30.4-0.61.3-0.7
Reaction time trials AUC0.10.51.70.60.7-0.5-0.9-0.5-0.70.6-0.8-0.20.3-0.61.3-0.9
Run reversals in cocaine runway, females1.51.72.3-1.4-1.31.51.21.31.1-1.21.21.4-1.51.3-1.50.4
Run reversals in cocaine runway, males1.11.22.3-0.7-0.90.81.21.10.9-1.50.90.8-1.51.1-1.31.0
Latency to leave start box in cocaine runway0.00.00.1-0.3-0.3-0.1-0.20.10.20.10.30.00.30.1-0.2-0.3
Latency to leave start box in cocaine runway, F0.50.61.0-1.0-1.00.70.30.81.0-0.30.90.8-0.50.7-0.7-0.6
Latency to leave start box in cocaine runway, M0.80.71.40.80.7-1.0-0.8-1.0-0.90.7-0.8-0.91.2-0.80.7-0.2
Std. dev. time between licks in bursts0.50.81.21.01.0-1.0-1.0-1.1-0.81.1-0.6-1.01.0-0.90.80.5
Total sessions with >9 infusions0.30.41.20.80.2-0.4-0.7-0.4-0.41.1-0.4-0.40.5-0.90.6-0.6
Short access day 1 total inactive lever presses0.20.53.50.5-0.30.1-0.7-0.10.20.70.20.20.4-0.50.8-1.9
Short access day 10 total inactive lever presses0.31.75.9-0.9-1.41.30.71.21.5-0.91.61.7-0.71.0-0.2-2.4
Short access day 1 total infusions1.52.94.92.01.4-1.6-1.9-1.7-1.42.2-1.5-1.71.9-2.01.7-0.4
Short access day 10 total infusions0.10.20.90.5-0.30.0-0.3-0.1-0.00.90.1-0.10.4-0.60.3-0.8
Short access total infusions0.20.20.90.60.0-0.2-0.4-0.3-0.21.0-0.1-0.20.6-0.70.5-0.5
Short access day 1 locomotion0.30.40.80.90.5-0.7-0.7-0.6-0.50.8-0.6-0.70.7-0.90.50.1
Short access day 10 total locomotion0.41.73.41.61.2-1.4-1.5-1.3-1.21.9-0.9-1.11.3-1.71.20.0
Short access total locomotion1.01.52.61.41.2-1.4-1.3-1.3-1.21.6-1.1-1.21.2-1.50.90.6
One hour access (0.3 mA shock)1.21.42.01.41.1-1.1-1.4-1.1-1.21.4-1.2-0.81.3-1.31.3-0.7
Compulsive drug intake1.42.13.01.51.7-1.7-1.6-1.6-1.41.2-1.6-1.31.5-1.21.60.5
One hour access (shock baseline)0.00.10.30.0-0.30.20.10.20.20.30.30.2-0.0-0.2-0.1-0.5
Social response proportion6.98.811.2-3.0-3.03.03.33.13.0-3.22.93.3-3.13.1-2.7-0.8
Social responses0.60.71.1-0.7-1.00.91.10.90.7-0.70.80.9-1.00.6-1.0-0.6
Social time1.42.33.4-1.6-1.61.51.41.51.8-1.21.81.8-1.71.2-1.60.1
Soleus weight0.20.51.1-0.5-0.90.70.60.61.0-0.51.00.8-0.70.5-0.5-0.6
Bone: stiffness0.20.40.7-0.6-0.70.50.40.60.8-0.80.70.3-0.80.5-0.6-0.2
Tibialis anterior weight1.34.55.8-2.3-2.32.22.42.22.2-2.42.12.1-2.02.3-1.9-0.5
Time to tail flick, vehicle, before self-admin4.04.97.0-2.4-2.32.61.62.42.3-1.92.32.7-2.12.1-1.7-2.3
Time to tail flick, vehicle, after self-admin0.30.61.1-0.6-0.90.80.70.81.0-0.61.00.9-0.80.7-0.7-0.6
Time to tail flick, test, before self-admin0.20.30.80.30.5-0.5-0.9-0.5-0.50.4-0.5-0.30.3-0.50.4-0.5
Time to tail flick, test, after self-admin0.90.96.90.70.3-0.1-1.0-0.3-0.11.2-0.10.10.5-0.91.0-2.6
Delta time to tail flick, vehicle, before/after SA1.01.11.61.31.0-1.3-0.9-1.2-0.91.1-0.9-1.21.2-1.20.90.4
Delta time to tail flick, test, before/after SA0.20.21.80.3-0.30.30.10.30.30.40.30.4-0.0-0.20.2-1.3
Tibia length3.49.312.5-3.4-3.33.33.03.33.0-3.13.23.0-3.53.0-2.7-1.0
Ambulatory time before self-admin0.30.92.1-0.6-0.61.01.00.90.9-1.20.81.1-1.51.1-0.60.5
Ambulatory time after self-admin0.60.92.90.81.3-1.1-0.6-0.9-1.10.5-1.1-0.90.7-0.50.71.7
Bone: tissue strength0.30.31.0-0.6-0.60.40.60.60.4-1.00.40.1-0.70.5-0.5-0.2
Total heroin consumption0.20.32.6-0.10.00.3-0.20.20.30.10.20.6-0.1-0.10.4-1.6
Bone: trabecular number0.10.20.60.40.5-0.4-0.3-0.5-0.10.7-0.2-0.30.5-0.40.10.8
Bone: trabecular spacing1.21.72.4-1.5-1.61.41.31.51.2-1.61.21.2-1.31.3-1.1-0.3
Bone: trabecular thickness0.10.10.7-0.20.5-0.10.1-0.20.20.60.10.40.10.1-0.20.8
Bone: trabecular tissue density0.20.31.8-0.70.10.20.80.30.2-0.70.4-0.0-0.00.7-0.31.3
Water consumed over 24 hours0.20.44.10.2-0.50.2-0.30.20.40.20.10.3-0.3-0.50.2-2.0
Number of responses in last shaping day1.41.82.91.61.1-1.1-1.7-1.2-1.31.6-1.3-0.90.9-1.61.7-1.1