Hub : Genes

Pcsk2

proprotein convertase subtilisin/kexin type 2

chr3:151333938–151636628 (+)

Pcsk2 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Pcsk2 0.08 0.04 1.1e-16 0.15 0.15 0.16 0.16 8.8e-16 4.4e-16 3.7e-17 1.3e-16
2 pVTA mRNA stability Pcsk2 0.13 0.06 4.9e-11 0.14 0.14 0.14 0.14 2.3e-11 1.4e-11 1.6e-11 1.2e-11
3 OFC gene expression Pcsk2 0.64 0.16 7.3e-12 0.35 0.31 0.34 0.36 3.5e-09 4.7e-08 5.6e-09 1.7e-09
4 IC gene expression Pcsk2 0.24 0.1 4.2e-14 0.3 0.29 0.25 0.3 6.8e-13 1.2e-12 5.2e-11 3.8e-13
5 NAcc gene expression Pcsk2 0.08 0.04 0.0e+00 0.1 0.12 0.11 0.11 2.0e-14 2.0e-17 1.8e-16 6.2e-16
6 BLA mRNA stability Pcsk2 0.3 0.15 4.8e-09 0.12 -0 0.1 0.01 9.2e-07 9.4e-01 9.6e-06 5.0e-02
7 Brain gene expression Pcsk2 0.47 0.13 0.0e+00 0.47 0.41 0.46 0.44 2.3e-49 6.0e-41 1.6e-47 6.2e-45
8 IC mRNA stability Pcsk2 0.17 0.09 6.1e-07 0.14 0.14 0.11 0.13 1.4e-06 2.1e-06 2.2e-05 3.3e-06
9 pVTA gene expression Pcsk2 0.47 0 0.0e+00 0.26 0.28 0.28 0.28 9.4e-21 5.8e-23 5.0e-23 1.5e-22
10 PL mRNA stability Pcsk2 0.04 0.03 3.0e-05 0.04 0.03 0.03 0.01 6.7e-05 3.6e-04 1.9e-04 2.7e-02
11 IL gene expression Pcsk2 0.34 0.22 4.4e-05 0.12 0.16 0.11 0.12 6.5e-04 8.9e-05 1.6e-03 7.8e-04
12 BLA gene expression Pcsk2 0.1 0.07 1.8e-04 0.06 0.04 0.01 0.04 3.2e-04 6.1e-03 8.0e-02 3.7e-03
13 Brain mRNA stability Pcsk2 0.17 0.09 1.3e-04 0.05 0.04 0.05 0.05 2.5e-05 2.2e-04 1.7e-05 1.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.5-0.20.4-0.2-0.3-0.4-0.0-0.70.2-0.40.2-0.30.10.5
Area under the delay curve0.40.44.5-0.20.50.6-0.3-0.30.20.10.10.00.20.30.52.1
BMI with tail13.145.158.77.7-6.97.37.17.0-7.16.8-7.06.5-6.76.96.8-0.3
BMI without tail10.833.041.56.4-6.06.26.16.1-5.96.2-5.75.8-5.85.95.5-0.7
Body weight16.170.290.09.5-8.88.78.98.8-8.88.8-8.78.5-8.88.57.9-1.7
Weight adjusted by age0.20.30.90.5-0.50.20.60.5-0.60.6-0.10.5-0.50.50.2-1.0
Bone surface0.20.30.90.4-0.70.50.70.5-0.90.1-0.80.5-0.80.30.4-0.5
Bone volume0.10.10.30.1-0.50.10.30.2-0.6-0.2-0.40.2-0.4-0.10.2-0.4
Breakpoint value in progressive ratio session0.10.10.20.4-0.30.40.40.4-0.40.3-0.40.3-0.50.30.3-0.3
Number of licking bursts0.10.21.50.10.2-0.1-0.2-0.2-0.2-0.4-0.30.10.1-0.10.21.2
Context. condit. distance diff. score0.10.10.3-0.40.3-0.3-0.3-0.30.1-0.40.3-0.40.4-0.6-0.3-0.1
Locomotion velocity, session 11.51.63.0-1.61.0-1.7-1.3-1.30.8-1.70.8-0.70.9-1.7-1.3-1.0
Locomotion distance, session 15.46.99.7-3.12.6-2.9-2.8-2.82.3-3.02.3-2.62.5-2.9-2.7-0.3
Locomotion velocity, session 22.32.73.9-1.91.6-1.8-1.8-1.81.6-2.01.6-1.41.6-1.8-1.60.1
Locomotion distance, session 26.59.113.7-3.72.8-3.5-3.1-3.12.8-3.12.8-2.73.0-3.4-3.3-1.2
Locomotion velocity, session 34.04.66.1-2.42.2-2.5-2.3-2.41.8-2.51.9-2.12.1-2.3-2.00.3
Locomotion distance, session 31.41.52.1-1.41.2-1.5-1.4-1.40.6-1.50.7-1.21.3-1.3-1.00.8
Stereotopy head waving bouts, day 30.00.10.40.1-0.1-0.00.20.20.20.30.10.2-0.20.10.1-0.6
Stereotopy head waving duration, day 30.10.10.20.3-0.40.20.40.30.10.4-0.00.3-0.30.20.3-0.5
Locomotion velocity, session 71.51.73.1-1.50.9-1.5-1.3-1.21.2-1.31.2-0.91.4-1.8-1.1-1.1
Locomotion distance, session 70.81.02.9-1.10.3-1.2-0.8-0.70.6-1.00.6-0.50.9-1.5-0.8-1.7
Stereotopy head waving bouts, day 70.60.61.21.0-0.70.80.80.8-0.41.1-0.60.8-0.91.00.80.4
Stereotopy head waving duration, day 70.10.10.40.3-0.00.10.10.00.10.3-0.00.0-0.30.30.20.6
Locomotion velocity, session 81.41.72.5-1.61.0-1.5-1.2-1.21.1-1.51.3-1.11.0-1.6-1.2-1.3
Locomotion distance, session 84.66.79.6-3.12.3-3.0-2.6-2.62.3-2.82.5-2.42.6-3.1-2.6-1.0
Degree of sensitization distance0.90.94.40.6-1.20.60.91.0-0.50.7-0.61.1-0.80.20.6-2.1
Degree of sensitization stereotypy0.70.81.21.1-0.80.90.90.8-0.70.9-0.80.9-1.10.90.90.4
Conditioned locomotion0.10.21.1-0.0-0.3-0.30.00.10.20.30.10.8-0.0-0.20.0-1.1
Cocaine response after cond. corrected2.32.83.8-1.91.6-1.8-1.6-1.61.9-1.51.8-1.51.8-1.8-1.9-0.5
Cocaine response after cond. not corrected3.33.95.0-2.21.9-2.1-2.0-1.92.2-1.82.1-1.82.2-2.1-2.1-0.3
Cocaine response before conditioning0.10.10.3-0.20.3-0.3-0.4-0.3-0.0-0.30.1-0.40.4-0.10.10.5
Saline control response0.70.98.30.3-1.1-0.00.70.8-0.40.6-0.30.7-0.4-0.20.2-2.9
Bone: connectivity density0.40.61.7-0.80.9-0.8-0.7-0.90.4-1.30.6-0.90.5-0.8-0.50.5
Bone: cortical apparent density0.30.52.0-0.41.0-0.2-0.7-0.60.4-0.40.4-0.80.6-0.1-0.61.4
Bone: cortical area0.30.50.80.8-0.50.90.70.7-0.70.8-0.60.5-0.50.90.60.5
Bone: cortical porosity0.50.51.00.9-0.30.70.60.5-0.80.7-1.00.4-0.51.00.80.7
Bone: cortical porosity0.80.91.61.1-0.70.90.90.9-1.11.0-1.30.8-0.81.11.00.3
Bone: cortical thickness0.40.74.50.80.30.90.30.3-0.40.7-0.3-0.0-0.11.00.92.1
Bone: cortical thickness0.30.42.3-0.30.7-0.3-0.4-0.6-0.2-1.0-0.1-0.6-0.0-0.10.01.5
Bone: cortical tissue density0.30.41.5-0.50.9-0.2-0.7-0.60.4-0.40.4-0.80.6-0.1-0.71.2
Condit. Reinf. active minus inactive responses0.10.10.40.10.20.1-0.00.0-0.00.6-0.0-0.00.30.40.10.3
Condit. Reinf. active-inactive response ratio0.10.10.30.10.00.20.00.1-0.10.6-0.1-0.00.30.40.20.3
Condit. Reinf. active responses0.10.10.2-0.20.4-0.2-0.3-0.20.20.30.2-0.10.40.1-0.20.3
Condit. Reinf. inactive responses0.00.10.4-0.10.0-0.3-0.00.00.1-0.00.00.3-0.2-0.2-0.3-0.6
Incentive salience index mean0.30.41.7-0.40.9-0.3-0.7-0.60.5-0.00.5-0.60.9-0.0-0.21.3
Condit. Reinf. lever presses0.40.54.8-0.10.80.1-0.5-0.50.5-0.10.5-0.40.60.20.12.2
Condit. Reinf. active minus inactive responses0.70.92.40.9-1.10.60.81.0-0.41.3-0.51.4-0.30.40.7-1.6
Condit. Reinf. active-inactive response ratio0.50.61.30.8-0.90.60.80.9-0.41.0-0.51.1-0.30.50.7-1.1
Condit. Reinf. active responses0.50.81.71.0-1.01.00.81.0-0.61.3-0.61.1-0.30.81.0-0.4
Condit. Reinf. inactive responses0.40.51.10.7-0.50.90.40.5-0.80.6-0.60.3-0.40.80.91.1
Condit. Reinf. lever presses2.43.44.62.0-2.21.71.91.9-2.01.6-1.92.0-1.71.32.1-1.2
Condit. Reinf. lever reinforcers received0.60.91.91.1-1.11.00.81.0-0.61.4-0.61.2-0.30.71.1-0.5
Conditioned reinforcement - actives2.44.16.9-2.51.5-2.6-1.5-1.61.7-2.61.6-2.11.3-2.4-2.3-2.2
Conditioned reinforcement - inactives2.33.47.7-2.11.3-2.1-1.1-1.31.6-2.31.6-1.60.9-1.8-2.5-2.8
Conditioned locomotion2.93.75.0-2.21.9-2.1-2.1-1.92.0-2.21.9-2.11.8-2.1-1.50.3
Patch foraging indifference point 0 sec0.71.28.1-1.30.1-0.9-0.3-0.50.4-1.00.4-0.80.4-1.1-1.2-2.8
Patch foraging indifference point AUC1.21.83.0-1.21.7-1.2-1.6-1.61.1-1.51.1-1.51.4-1.2-0.81.1
Delay disc. indifference point, 0s delay0.91.03.10.7-0.51.30.70.7-0.51.1-0.61.0-0.71.11.41.8
Delay disc. indifference point, 16s delay0.91.02.3-0.91.3-0.7-1.1-1.11.1-0.81.0-0.91.1-0.6-0.61.5
Delay disc. indifference point, 2s delay1.41.63.10.9-1.01.61.11.1-1.01.2-1.01.4-1.11.31.81.4
Delay disc. indifference point, 24s delay1.41.52.5-1.21.6-0.8-1.3-1.41.4-0.91.3-1.41.2-0.8-0.81.5
Delay disc. indifference point, 4s delay1.11.12.20.8-0.81.50.90.9-0.91.0-1.01.0-1.01.11.41.3
Delay disc. indifference point, 8s delay0.40.42.3-0.80.80.1-0.7-0.70.5-0.20.5-0.40.7-0.2-0.31.5
Indifference point function ln k0.51.02.30.5-1.20.51.00.9-1.20.4-1.21.0-1.40.50.5-1.5
Indifference point function log k0.51.02.30.5-1.20.51.00.9-1.20.4-1.21.0-1.40.50.5-1.5
Patch foraging total patch changes 0 sec0.81.56.7-1.60.5-1.2-0.6-0.80.6-1.30.6-1.10.7-1.4-1.5-2.6
Patch foraging total patch changes 12 sec0.10.11.00.1-0.30.30.30.3-0.20.1-0.1-0.0-0.30.00.0-1.0
Patch foraging total patch changes 18 sec1.72.63.4-1.91.5-1.8-1.6-1.61.6-1.51.7-1.51.7-1.8-1.7-1.0
Patch foraging total patch changes 24 sec0.50.81.2-1.00.9-0.9-0.9-0.81.0-0.51.0-0.81.1-1.0-0.7-1.0
Patch foraging total patch changes 6 sec0.50.71.2-1.10.7-0.6-0.7-0.70.7-0.80.8-1.10.8-0.8-0.9-1.0
Patch foraging time to switch 0 sec1.53.25.32.2-1.82.11.92.0-1.42.3-1.51.7-1.52.01.60.5
Patch foraging water rate 0 sec1.94.05.3-2.32.2-2.3-2.1-2.21.9-2.11.9-1.91.8-2.0-2.0-0.3
Patch foraging water rate 12 sec2.65.57.1-2.52.6-2.3-2.6-2.52.5-2.22.6-2.72.4-2.0-2.21.1
Patch foraging water rate 18 sec5.88.912.1-3.43.1-3.4-3.1-3.12.8-3.03.1-3.02.7-3.0-3.5-0.9
Patch foraging water rate 24 sec3.75.27.8-2.62.4-2.8-2.2-2.42.2-2.22.4-2.02.1-2.4-2.6-0.9
Patch foraging water rate 6 sec2.84.05.4-2.32.3-2.3-2.2-2.22.1-1.62.2-1.91.9-1.6-2.30.2
Seeking ratio, delayed vs. immediate footshock0.70.81.90.6-1.10.50.90.8-1.30.3-1.40.9-0.90.50.7-1.2
Distance traveled before self-admin0.70.92.00.6-0.61.10.90.9-0.81.3-0.81.4-1.21.10.80.6
Distance traveled after self-admin0.50.62.6-0.51.1-0.4-0.9-0.70.9-0.30.9-0.50.6-0.3-0.51.6
Extensor digitorum longus weight0.41.73.11.2-1.51.21.41.3-1.81.0-1.61.3-1.61.20.8-0.8
Bone: elastic displacement0.30.40.90.7-0.50.80.50.6-0.70.5-0.70.5-0.50.70.90.5
Bone: elastic work3.54.56.62.4-1.92.62.02.1-2.42.1-2.21.8-1.92.32.51.1
Bone: endosteal estimation2.65.810.32.0-3.22.12.62.6-2.52.0-2.52.8-2.81.61.5-2.4
Bone: endosteal perimeter0.51.05.80.4-1.30.31.01.0-0.30.9-0.31.2-0.70.20.0-2.4
Epididymis fat weight13.646.456.87.5-7.26.87.17.0-7.57.1-7.56.9-6.96.66.6-1.7
Delta time in closed arm before/after self-admin0.20.21.0-0.4-0.0-0.4-0.4-0.40.0-1.00.1-0.70.6-0.6-0.20.2
Delta time in open arm before/after self-admin1.71.72.91.5-1.11.11.31.4-1.21.7-1.21.4-1.51.41.1-0.6
Diff in mean of infusions in LGA sessions0.30.42.10.30.10.90.20.30.10.80.20.0-0.10.80.61.5
Delay discount exponential model param0.40.44.00.4-0.6-0.40.40.4-0.40.1-0.30.2-0.4-0.1-0.3-2.0
Extinction: sum of active levers before priming0.10.10.5-0.50.1-0.2-0.3-0.2-0.2-0.3-0.2-0.30.0-0.3-0.4-0.7
Active lever presses in extinction session 60.90.91.50.9-0.90.81.21.1-1.10.5-1.11.1-1.20.70.7-1.1
Bone: final force0.81.21.91.1-1.21.21.11.1-1.41.2-1.21.1-0.91.21.10.3
Bone: final moment0.61.01.70.9-1.21.11.01.0-1.31.0-1.10.9-0.91.01.00.1
Food consumed during 24 hour testing period0.20.30.70.5-0.70.50.60.6-0.80.3-0.70.3-0.60.40.1-0.3
Glucose2.23.54.81.8-2.21.51.91.9-2.12.0-2.12.0-1.81.61.5-1.7
Heart weight1.52.45.01.6-1.61.41.71.8-1.32.2-1.21.4-1.61.31.1-1.5
Delay discount hyperbolic model param0.30.43.4-0.0-0.2-0.70.00.00.0-0.20.1-0.20.0-0.4-0.6-1.9
Intermittent access intake day 1-15 change0.10.21.70.2-0.40.20.50.5-0.40.1-0.30.1-0.4-0.00.3-1.3
Intermittent access intake escalation0.10.11.4-0.0-0.20.00.30.4-0.20.1-0.00.0-0.3-0.20.2-1.2
Intermittent access intake escalation 20.40.40.80.6-0.30.40.80.8-0.60.9-0.50.6-0.80.60.3-0.8
Intermitt. access day 1 inactive lever presses0.10.51.30.5-0.60.40.70.6-0.70.5-0.80.3-1.10.6-0.3-1.2
Intermitt. access day 15 inactive lever presses0.61.311.6-0.1-0.7-0.30.80.6-0.8-0.5-0.8-0.3-0.8-0.1-0.9-3.4
Intermitt. access escalation Index0.50.71.30.9-1.11.10.80.9-0.90.5-0.90.8-0.70.81.00.0
Intermittent access day 1 total infusions0.10.10.40.2-0.60.30.50.4-0.20.0-0.4-0.1-0.40.20.1-0.3
Intermittent access day 15 total infusions0.30.42.00.2-0.90.40.70.7-0.60.1-0.60.0-0.50.10.4-1.4
Intermittent access terminal intake (last 3 days)0.50.71.60.6-1.10.71.01.0-0.80.4-0.90.4-0.80.40.6-1.3
Intermittent access total infusions0.20.31.00.3-0.70.40.70.6-0.40.1-0.50.1-0.60.20.1-1.0
Intermittent access day 1 locomotion0.20.31.0-0.50.4-0.4-0.5-0.50.6-0.70.3-0.50.4-0.4-0.31.0
Intermittent access day 15 total locomotion0.20.31.1-0.60.4-0.7-0.4-0.40.3-1.00.2-0.70.3-0.8-0.3-0.3
Intermittent access total locomotion0.91.11.7-1.21.0-1.1-1.0-1.01.1-1.30.9-1.21.1-1.2-0.80.6
Intermittent access standard deviation0.20.40.9-0.90.7-0.6-0.5-0.50.6-0.50.6-0.60.2-0.7-0.7-0.8
Left kidney weight1.77.79.83.1-3.02.92.92.9-3.13.0-3.12.7-2.72.72.4-1.2
Right kidney weight0.62.84.81.6-1.81.61.81.8-1.82.2-1.61.7-1.81.81.0-1.2
Cocaine induced anxiety0.10.10.3-0.50.3-0.4-0.4-0.30.3-0.30.4-0.50.3-0.3-0.5-0.0
Post-drug Anxiety1.82.02.41.5-1.51.51.41.4-1.61.3-1.51.4-1.41.41.5-0.3
Baseline Anxiety5.36.27.92.8-2.52.72.42.5-2.52.5-2.72.7-2.52.42.7-0.5
Tail length0.72.73.71.7-1.91.51.71.7-1.61.8-1.51.9-1.91.41.3-1.2
Length with tail3.214.118.24.1-4.13.54.04.0-3.84.0-3.74.0-4.33.53.1-2.1
Length without tail3.210.313.73.7-3.33.13.53.3-3.53.2-3.63.2-3.43.22.9-1.1
LgA early post infusion interval0.10.20.4-0.0-0.40.60.30.3-0.30.3-0.50.7-0.20.10.60.0
LgA late post infusion interval0.60.88.20.60.10.5-0.10.00.10.0-0.10.00.30.40.82.9
LgA early loading0.20.31.31.1-0.40.20.50.5-0.30.8-0.20.1-0.50.90.20.3
LgA late loading0.10.32.80.2-0.3-0.30.30.1-0.0-0.00.1-0.3-0.4-0.1-0.4-1.7
LgA early average infusions0.20.20.5-0.10.5-0.4-0.2-0.30.5-0.10.7-0.70.30.0-0.70.2
LgA late average infusions0.50.83.0-0.80.5-0.8-0.4-0.60.7-0.60.9-0.90.4-0.9-1.3-1.7
LgA early timeout0.20.21.10.30.30.1-0.1-0.10.40.10.6-0.70.30.3-0.11.0
LgA late timeout0.00.10.20.1-0.10.40.30.30.00.40.3-0.0-0.30.40.1-0.1
LgA early titration0.20.20.9-0.30.5-0.7-0.2-0.40.5-0.20.6-0.70.2-0.3-1.0-0.2
LgA late titration0.91.43.3-1.21.0-1.5-0.9-1.10.9-0.91.0-1.20.9-1.2-1.8-1.3
LgA total infusion0.10.20.7-0.30.4-0.4-0.2-0.30.4-0.20.6-0.70.2-0.2-0.8-0.5
Times rat made contact with spout1.92.23.31.5-1.71.41.71.6-1.71.1-1.51.8-1.61.01.4-1.0
Lifetime Intake0.10.10.7-0.2-0.3-0.10.20.1-0.1-0.4-0.2-0.3-0.2-0.2-0.3-0.9
Liver weight, left2.94.86.82.3-2.62.42.42.4-2.22.1-2.12.1-2.31.91.9-1.3
Liver weight, right3.66.39.52.5-3.12.52.62.6-2.72.3-2.72.8-2.52.22.4-1.6
Locomotor activity0.40.60.80.9-0.80.80.70.7-0.70.8-0.70.8-0.70.70.9-0.5
Locomotor testing distance0.10.10.4-0.40.6-0.3-0.4-0.50.4-0.30.3-0.30.4-0.3-0.30.1
Locomotor testing rearing0.10.10.4-0.20.6-0.4-0.4-0.50.5-0.30.4-0.20.4-0.3-0.40.1
Locomotion in novel chamber1.01.31.9-1.01.0-1.3-1.2-1.30.9-1.41.0-1.41.1-1.3-1.1-0.4
Locomotion in novel chamber post-restriction1.82.94.9-1.11.6-2.2-2.0-2.01.4-2.11.4-1.91.7-1.9-1.50.4
Fecal boli incidents, locomotor time 10.40.52.5-1.10.1-0.7-0.4-0.50.1-0.80.40.00.1-0.9-0.6-1.6
Change in fecal boli incidents, locomotor task0.30.31.00.50.5-0.7-0.5-0.40.6-0.10.3-1.00.8-0.2-0.60.2
Time >=10cm from walls, locomotor time 10.10.20.4-0.10.4-0.7-0.4-0.40.60.30.5-0.20.3-0.1-0.50.1
Bouts of movement, locomotor time 10.80.91.6-1.30.9-1.0-0.8-1.00.7-1.30.9-0.40.3-1.1-1.2-0.6
Total resting periods, locomotor time 11.21.42.5-1.51.1-1.3-1.1-1.20.9-1.61.0-0.70.5-1.3-1.5-0.9
Rest time, locomotor task time 10.40.53.3-0.50.3-0.9-0.3-0.40.2-0.70.3-0.10.2-0.7-0.9-1.8
Distance moved, locomotor task time 10.81.36.4-0.61.2-0.3-1.0-0.91.3-0.31.1-1.41.1-0.2-0.42.5
Vertical activity count, locomotor time 10.20.42.20.6-0.30.70.40.5-0.10.6-0.30.0-0.40.70.61.5
Time >=10cm from walls, locomotor time 21.62.44.62.1-1.60.91.61.6-1.61.8-1.71.4-1.71.51.5-0.5
Bouts of movement, locomotor time 20.10.10.60.1-0.20.60.30.3-0.00.5-0.30.8-0.20.30.20.3
Total resting periods, locomotor time 20.10.20.80.1-0.30.60.40.4-0.10.5-0.30.9-0.30.40.20.1
Rest time, locomotor task time 20.10.21.3-0.3-0.20.10.30.2-0.3-0.1-0.20.7-0.20.0-0.2-1.1
Distance moved, locomotor task time 20.91.12.8-0.51.1-0.8-1.3-1.11.2-0.41.0-1.31.1-0.7-0.51.7
Vertical activity count, locomotor time 20.20.32.20.00.30.0-0.5-0.30.50.50.3-0.30.40.00.11.5
Light reinforcement 10.30.71.9-0.80.6-1.1-0.4-0.60.5-0.90.5-0.50.3-1.1-1.1-1.4
Light reinforcement 20.50.73.1-0.80.3-1.3-0.2-0.50.0-0.90.2-0.70.1-1.0-0.9-1.8
Bone: marrow area2.65.610.02.0-3.22.02.62.5-2.51.9-2.42.8-2.71.61.4-2.5
Bone: maximum diameter0.61.12.10.9-1.30.61.31.2-1.10.7-1.11.3-1.20.50.5-1.4
Bone: maximum force0.61.11.71.0-1.11.21.01.0-1.31.3-1.10.9-0.71.21.00.3
Bone: maximum moment0.61.01.61.0-1.01.21.01.0-1.31.2-1.10.8-0.81.21.00.2
Mean time between licks in bursts0.20.40.8-0.60.7-0.3-0.6-0.70.5-0.50.4-0.90.6-0.4-0.80.8
Mean num. licks in bursts0.71.23.80.7-1.30.81.21.2-0.91.0-0.71.1-1.20.60.7-1.9
Cd content in liver0.40.51.60.5-0.80.60.40.5-0.80.3-0.90.7-0.50.41.2-0.2
Co content in liver0.50.60.9-0.90.5-0.8-0.7-0.70.5-0.90.6-0.80.7-0.9-0.8-0.6
Cu content in liver0.10.10.2-0.40.3-0.3-0.3-0.30.1-0.40.1-0.20.2-0.3-0.5-0.4
Fe content in liver1.82.24.51.8-1.12.01.41.5-0.82.1-1.31.1-0.91.91.50.7
K content in liver1.41.44.7-0.71.5-0.5-1.1-1.21.1-0.91.1-1.51.2-0.3-0.52.2
Mg content in liver0.10.10.70.30.10.50.00.10.10.50.2-0.30.30.40.30.8
Mn content in liver1.82.03.5-1.80.8-1.5-1.2-1.11.3-1.11.6-1.31.3-1.6-1.9-1.5
Na content in liver0.40.44.30.30.60.3-0.1-0.2-0.1-0.3-0.3-0.20.10.30.32.1
Rb content in liver1.01.22.11.2-0.91.51.01.0-1.11.1-1.01.0-1.11.31.10.6
Se content in liver1.01.12.41.3-0.61.31.11.0-1.01.3-1.00.9-0.91.50.70.8
Sr content in liver1.41.21.8-1.30.8-1.2-1.0-1.01.0-1.31.3-1.01.1-1.3-0.9-0.8
Zn content in liver0.20.31.0-0.10.70.0-0.4-0.40.40.20.5-0.80.80.1-0.21.0
Bone: minimum diameter0.50.91.40.9-1.11.11.11.1-0.81.2-0.71.1-0.80.90.6-0.5
Time in familiar zone, hab. session 10.20.21.20.4-0.30.50.20.2-0.30.1-0.40.4-0.40.50.61.1
Time in novel zone, hab. session 10.20.20.70.4-0.50.30.50.5-0.20.6-0.50.4-0.40.30.3-0.8
Total zone transitions, hab. session 11.01.42.5-1.41.1-1.6-1.2-1.30.8-1.50.7-1.10.9-1.4-1.2-0.3
Total locomotion distance, hab. session 11.42.02.8-1.61.4-1.7-1.6-1.61.3-1.51.2-1.51.4-1.5-1.5-0.1
Locomotion velocity, hab. session 12.43.34.2-2.01.9-2.0-2.0-2.01.7-1.91.7-1.91.8-1.9-1.90.1
Time in familiar zone, hab. session 20.50.50.9-0.90.6-1.0-0.8-0.71.0-0.60.9-0.40.7-0.8-0.60.0
Time in novel zone, hab. session 21.51.52.11.4-1.21.41.31.3-1.51.1-1.41.0-1.21.11.0-0.8
Total zone transitions, hab. session 20.20.30.9-0.60.3-0.8-0.4-0.40.1-0.50.3-0.00.3-0.8-0.7-1.0
Total locomotion distance, hab. session 21.21.62.8-1.60.8-1.5-1.2-1.10.8-1.21.0-0.71.2-1.7-1.5-1.4
Locomotion velocity, hab. session 22.02.74.3-2.01.3-2.0-1.7-1.61.2-1.71.4-1.21.7-2.1-1.9-1.1
Novel to familiar place preference ratio0.00.00.20.1-0.1-0.00.00.1-0.30.2-0.4-0.0-0.00.00.1-0.4
Novelty place preference0.00.00.20.2-0.10.10.10.1-0.30.2-0.50.0-0.10.20.2-0.1
Time in novel zone, NPP test0.30.30.70.6-0.50.50.50.5-0.60.6-0.80.4-0.50.50.5-0.3
Total zone transitions, NPP test1.21.72.4-1.51.2-1.5-1.4-1.31.1-1.41.1-1.21.4-1.5-1.3-0.1
Total locomotion distance, NPP test2.73.65.5-2.31.6-2.3-1.9-1.91.6-2.01.6-1.92.0-2.4-2.0-1.1
Locomotion velocity, NPP test3.44.87.0-2.61.9-2.6-2.3-2.21.9-2.31.9-2.22.4-2.6-2.3-0.8
Intraocular pressure0.20.31.5-0.6-0.4-0.5-0.3-0.30.1-0.5-0.1-0.50.3-0.6-0.0-1.2
Delta distance traveled before/after self-admin2.83.04.0-1.22.0-1.5-1.9-1.71.9-1.62.0-2.02.0-1.5-1.31.6
Delta ambulatory time before/after self-admin1.82.23.1-1.11.7-1.4-1.7-1.51.6-1.41.7-1.81.7-1.3-1.11.1
Parametrial fat weight26.361.878.88.9-8.17.88.28.2-8.77.7-8.68.2-8.57.67.4-1.6
Pavlov. Cond. lever latency1.31.77.90.8-1.70.51.31.3-1.11.1-1.11.2-1.30.50.5-2.8
Pavlov. Cond. magazine entry latency1.01.32.71.3-0.41.30.80.8-0.81.3-1.01.0-0.91.61.31.6
Pavlov. Cond. change in total contacts1.11.28.7-0.31.40.0-0.9-0.90.9-0.30.8-0.91.00.3-0.03.0
Pavlov. Cond. index score0.70.99.00.30.90.5-0.4-0.40.30.10.2-0.30.30.70.53.0
Pavlov. Cond. latency score1.01.29.5-0.31.4-0.1-0.9-0.90.8-0.50.7-0.80.90.20.03.1
Pavlov. Cond. lever contacts0.50.65.7-0.00.90.2-0.5-0.60.4-0.30.4-0.30.50.20.12.4
Pavlov. Cond. magazine entry number1.21.63.6-1.40.5-1.4-0.8-0.90.9-1.41.1-1.10.8-1.7-1.5-1.9
Pavlov. Cond. intertrial magazine entries2.42.95.8-2.11.0-2.0-1.2-1.11.6-1.11.8-1.31.5-1.9-2.3-2.4
Pavlov. Cond. lever-magazine prob. diff.0.91.110.60.50.80.7-0.2-0.20.10.30.1-0.20.20.90.73.3
Pavlov. Cond. response bias0.91.25.31.2-0.11.30.50.6-0.61.1-0.60.7-0.51.51.12.3
Pavlov. Cond. lever latency3.75.06.6-2.62.5-2.3-2.4-2.42.4-2.22.2-2.52.0-1.9-2.40.8
Pavlov. Cond. magazine entry latency2.53.15.91.4-2.11.21.81.7-2.11.1-2.11.9-1.90.81.4-2.4
Pavlov. Cond. change in total contacts3.65.87.82.7-2.72.62.52.7-2.32.8-2.32.8-2.02.12.4-0.7
Pavlov. Cond. index score4.25.77.72.6-2.82.32.52.5-2.62.2-2.62.7-2.31.82.4-1.4
Pavlov. Cond. latency score3.24.25.72.2-2.42.02.22.2-2.31.8-2.22.4-2.01.62.1-1.1
Pavlov. Cond. lever contacts3.95.37.02.6-2.62.42.42.5-2.52.3-2.32.5-2.11.92.4-0.9
Pavlov. Cond. magazine entry number3.03.75.2-1.82.3-1.7-2.0-2.02.2-1.62.1-2.32.0-1.2-1.71.9
Pavlov. Cond. intertrial magazine entries1.11.62.8-1.01.5-0.7-1.3-1.21.7-0.61.7-1.51.6-0.5-0.91.5
Pavlov. Cond. lever-magazine prob. diff.4.96.58.32.8-2.92.52.72.7-2.82.4-2.72.8-2.52.12.7-1.1
Pavlov. Cond. response bias4.56.28.72.6-2.92.32.62.6-2.72.3-2.72.8-2.31.82.4-2.0
LgA PC1 addiction-like behavior0.10.21.00.5-0.30.10.50.4-0.30.3-0.20.1-0.60.4-0.1-1.0
Time in closed arm before self-admin0.20.20.90.5-0.50.30.50.4-0.30.3-0.30.7-0.40.10.2-0.9
Time in closed arm after self-admin0.50.61.6-0.50.2-0.9-0.6-0.70.4-1.30.4-0.70.8-1.2-0.7-0.9
Time in open arm before self-admin0.20.21.4-0.30.5-0.4-0.4-0.40.5-0.20.6-0.40.40.0-0.21.2
Time in open arm after self-admin0.60.61.90.9-0.30.60.60.7-0.41.4-0.40.7-0.71.20.81.0
Bone: periosteal estimation1.63.45.41.7-2.31.82.02.0-2.01.7-1.92.1-2.01.51.3-1.4
Bone: periosteal perimeter0.20.42.30.3-0.60.10.50.6-0.00.70.00.9-0.20.1-0.0-1.5
Bone: post-yield work0.10.10.60.1-0.20.10.20.30.10.80.10.3-0.00.3-0.2-0.6
Progressive ratio test 1 active lever presses0.10.10.20.1-0.40.10.40.3-0.3-0.4-0.30.0-0.40.0-0.2-0.4
Progressive ratio test 1 breakpoint0.10.10.30.2-0.50.20.50.4-0.5-0.3-0.50.2-0.50.1-0.1-0.4
Progressive ratio test 1 inactive lever presses0.40.63.7-0.5-0.1-0.70.2-0.1-0.3-1.1-0.5-0.4-0.3-0.6-1.0-1.9
Progressive ratio test 2 active lever presses0.10.10.5-0.30.1-0.20.10.00.2-0.40.3-0.4-0.0-0.3-0.3-0.7
Progressive ratio test 2 breakpoint0.10.10.6-0.40.1-0.30.0-0.00.3-0.40.3-0.4-0.0-0.3-0.4-0.7
Progressive ratio test 2 inactive lever presses0.40.74.00.2-0.8-0.00.90.7-0.8-0.4-0.90.3-1.0-0.0-0.2-2.0
ShA PR total presses0.70.81.41.2-0.70.91.00.9-0.71.0-0.60.6-0.81.20.70.8
Incentive Sensitization - Responses0.30.41.0-0.70.5-0.6-0.3-0.30.8-0.40.7-0.80.4-0.6-0.6-1.0
Incentive Sensitization - Breakpoint0.30.41.1-0.70.5-0.7-0.3-0.30.8-0.50.8-0.80.4-0.6-0.6-1.0
LgA PR total presses1.41.42.0-1.01.2-1.4-1.2-1.21.3-1.21.4-1.31.1-1.2-1.3-0.3
Sum of active levers in priming session hrs 5-60.30.30.5-0.60.7-0.5-0.5-0.50.2-0.70.3-0.60.3-0.6-0.7-0.6
Progressive ratio1.82.84.2-1.51.4-2.0-1.5-1.71.4-2.11.2-1.91.5-2.0-1.7-1.7
Food seeking constrained by brief footshock4.45.47.6-2.42.8-2.1-2.5-2.52.5-2.32.4-2.32.5-2.3-2.21.0
Seeking ratio, punishment vs. effort0.40.53.30.4-0.20.90.40.5-0.20.6-0.00.8-0.30.80.71.8
Retroperitoneal fat weight30.7131.1169.613.0-11.812.112.212.0-12.211.5-12.011.3-12.211.510.8-1.9
Reaction time number correct0.30.61.8-0.70.8-1.0-0.6-0.70.8-0.70.9-0.50.4-0.7-1.3-0.6
Reaction time mean minus median1.12.64.91.6-1.61.01.71.6-2.01.3-2.21.9-1.91.31.1-1.2
Reaction time mean minus median AUC0.92.24.81.4-1.50.81.71.5-2.10.7-2.21.7-1.91.01.0-1.1
Reaction time num false alarms2.12.94.2-2.01.5-1.8-1.7-1.71.6-2.01.6-1.61.7-2.0-1.6-0.5
Reaction time num false alarms AUC1.72.64.1-1.91.5-1.6-1.7-1.71.4-2.01.6-1.61.7-1.9-1.4-0.2
Reaction time trials correct on left0.30.61.8-0.70.8-1.0-0.6-0.70.8-0.70.9-0.50.4-0.7-1.3-0.6
Reaction time trials on left0.30.51.6-0.70.7-1.0-0.6-0.60.7-0.70.8-0.40.3-0.6-1.3-0.7
Reaction time mean2.84.45.72.3-2.21.92.32.3-2.31.9-2.42.3-2.21.82.0-1.1
Reaction time mean AUC2.54.05.32.2-2.11.92.22.2-2.21.8-2.32.2-2.11.71.9-1.0
Median of all reaction times2.53.54.72.2-2.01.92.12.1-2.01.7-2.02.0-1.91.61.9-0.8
Reaction time omissions1.01.42.31.2-1.31.01.31.1-1.50.6-1.51.4-1.40.91.1-0.5
Reaction time false alarm rate1.11.52.5-1.51.0-1.1-1.3-1.31.1-1.61.1-1.21.4-1.5-0.80.2
Reaction time premature initiation rate0.30.42.2-0.70.4-0.6-0.3-0.30.3-0.80.4-0.50.1-0.7-0.9-1.5
Reaction time premature initiations0.61.03.0-1.00.8-1.1-0.6-0.70.7-1.20.8-0.60.3-1.1-1.5-1.7
Std. dev. reaction times1.93.65.82.0-1.91.62.01.9-2.31.6-2.42.1-2.01.61.7-1.0
Reaction time trials completed0.30.51.6-0.70.7-1.0-0.6-0.60.7-0.70.8-0.40.3-0.6-1.3-0.7
Reaction time trials AUC0.30.51.7-0.60.7-0.9-0.5-0.50.7-0.60.8-0.30.2-0.6-1.3-0.9
Run reversals in cocaine runway, females1.71.72.31.4-1.31.21.51.3-1.11.2-1.21.5-1.41.31.50.4
Run reversals in cocaine runway, males1.21.22.30.7-0.91.20.81.1-0.91.5-0.91.5-0.81.11.31.0
Latency to leave start box in cocaine runway0.00.00.10.3-0.3-0.2-0.10.1-0.2-0.1-0.3-0.3-0.00.10.2-0.3
Latency to leave start box in cocaine runway, F0.50.61.01.0-1.00.30.70.8-1.00.3-0.90.5-0.80.70.7-0.6
Latency to leave start box in cocaine runway, M0.80.71.4-0.80.7-0.8-1.0-1.00.9-0.70.8-1.20.9-0.8-0.7-0.2
Std. dev. time between licks in bursts0.60.81.2-1.01.0-1.0-1.0-1.10.8-1.10.6-1.01.0-0.9-0.80.5
Total sessions with >9 infusions0.30.41.2-0.80.2-0.7-0.4-0.40.4-1.10.4-0.50.4-0.9-0.6-0.6
Short access day 1 total inactive lever presses0.30.53.5-0.5-0.3-0.70.1-0.1-0.2-0.7-0.2-0.4-0.2-0.5-0.8-1.9
Short access day 10 total inactive lever presses0.71.75.90.9-1.40.71.31.2-1.50.9-1.60.7-1.71.00.2-2.4
Short access day 1 total infusions2.22.94.9-2.01.4-1.9-1.6-1.71.4-2.21.5-1.91.7-2.0-1.7-0.4
Short access day 10 total infusions0.20.20.9-0.5-0.3-0.30.0-0.10.0-0.9-0.1-0.40.1-0.6-0.3-0.8
Short access total infusions0.20.20.9-0.60.0-0.4-0.2-0.30.2-1.00.1-0.60.2-0.7-0.5-0.5
ShA early post infusion interval0.30.30.4-0.50.6-0.6-0.6-0.60.3-0.60.4-0.20.4-0.3-0.60.6
ShA late post infusion interval1.51.52.40.7-1.31.61.11.2-1.41.1-1.41.4-1.40.91.2-0.9
ShA early loading0.10.10.4-0.10.1-0.3-0.1-0.20.10.20.1-0.4-0.00.1-0.6-0.3
ShA late loading0.10.10.70.4-0.20.40.30.20.00.30.10.0-0.00.50.30.8
Short access day 1 locomotion0.40.40.8-0.90.5-0.7-0.7-0.60.5-0.80.6-0.70.7-0.9-0.50.1
Short access day 10 total locomotion0.91.73.4-1.61.2-1.5-1.4-1.31.2-1.90.9-1.31.1-1.7-1.20.0
Short access total locomotion1.31.52.6-1.41.2-1.3-1.3-1.31.2-1.61.1-1.21.2-1.5-0.90.6
ShA early average infusions0.00.00.1-0.1-0.00.20.10.00.00.30.1-0.3-0.20.3-0.4-0.4
ShA late average infusions0.80.81.71.3-0.70.81.00.8-0.60.9-0.60.6-0.91.30.81.0
ShA early timeout0.90.91.61.2-1.01.01.11.0-0.81.2-0.70.6-1.11.30.90.1
ShA late timeout0.80.92.01.4-1.00.91.11.0-0.70.7-0.70.6-0.91.21.00.6
ShA early titration0.20.31.20.3-0.50.40.70.5-0.40.4-0.30.1-0.60.4-0.1-1.1
ShA late titration0.20.20.6-0.10.5-0.7-0.2-0.50.6-0.50.6-0.70.4-0.2-0.8-0.1
ShA total infusions0.10.20.50.7-0.20.30.40.3-0.10.4-0.10.0-0.40.70.20.5
One hour access (0.3 mA shock)1.21.42.0-1.41.1-1.4-1.1-1.11.2-1.41.2-1.30.8-1.3-1.3-0.7
Shock compulsivity0.20.31.8-0.50.2-0.3-0.4-0.30.3-0.40.3-1.00.3-0.5-0.6-1.4
Compulsive drug intake1.82.13.1-1.51.7-1.6-1.7-1.61.4-1.21.6-1.51.3-1.2-1.60.5
One hour access (shock baseline)0.00.10.3-0.0-0.30.10.20.2-0.2-0.3-0.30.0-0.2-0.20.1-0.5
Social response proportion7.78.811.23.0-3.03.33.03.1-3.03.2-2.93.1-3.33.12.7-0.8
Social responses0.60.71.10.7-1.01.10.90.9-0.70.7-0.81.0-0.90.61.0-0.6
Social time1.72.33.41.6-1.61.41.51.5-1.81.2-1.81.7-1.81.21.60.1
Soleus weight0.20.51.10.5-0.90.60.70.6-1.00.5-1.00.7-0.80.50.5-0.6
Bone: stiffness0.20.40.70.6-0.70.40.50.6-0.80.8-0.70.8-0.30.50.6-0.2
Tibialis anterior weight1.34.55.82.3-2.32.42.22.2-2.22.4-2.12.0-2.12.31.9-0.5
Time to tail flick, vehicle, before self-admin4.74.97.02.4-2.31.62.62.4-2.31.9-2.32.1-2.72.11.7-2.3
Time to tail flick, vehicle, after self-admin0.50.61.10.6-0.90.70.80.8-1.00.6-1.00.8-0.90.70.7-0.6
Time to tail flick, test, before self-admin0.20.30.8-0.30.5-0.9-0.5-0.50.5-0.40.5-0.30.3-0.5-0.4-0.5
Time to tail flick, test, after self-admin0.90.96.9-0.70.3-1.0-0.1-0.30.1-1.20.1-0.5-0.1-0.9-1.0-2.6
Delta time to tail flick, vehicle, before/after SA1.21.11.6-1.31.0-0.9-1.3-1.20.9-1.10.9-1.21.2-1.2-0.90.4
Delta time to tail flick, test, before/after SA0.20.21.8-0.3-0.30.10.30.3-0.3-0.4-0.30.0-0.4-0.2-0.2-1.3
Tibia length3.49.312.53.4-3.33.03.33.3-3.03.1-3.23.5-3.03.02.7-1.0
Ambulatory time before self-admin0.60.92.10.6-0.61.01.00.9-0.91.2-0.81.5-1.11.10.60.5
Ambulatory time after self-admin0.80.92.9-0.81.3-0.6-1.1-0.91.1-0.51.1-0.70.9-0.5-0.71.7
Bone: tissue strength0.30.31.00.6-0.60.60.40.6-0.41.0-0.40.7-0.10.50.5-0.2
Total heroin consumption0.20.32.60.10.0-0.20.30.2-0.3-0.1-0.20.1-0.6-0.1-0.4-1.6
Total infusions0.10.20.7-0.30.4-0.4-0.2-0.30.4-0.20.6-0.70.2-0.2-0.8-0.4
Bone: trabecular number0.10.20.6-0.40.5-0.3-0.4-0.50.1-0.70.2-0.50.3-0.4-0.10.8
Bone: trabecular spacing1.31.72.41.5-1.61.31.41.5-1.21.6-1.21.3-1.21.31.1-0.3
Bone: trabecular thickness0.10.10.70.20.50.1-0.1-0.2-0.2-0.6-0.1-0.1-0.40.10.20.8
Bone: trabecular tissue density0.20.31.80.70.10.80.20.3-0.20.7-0.40.00.00.70.31.3
Water consumed over 24 hours0.30.44.1-0.2-0.5-0.30.20.2-0.4-0.2-0.10.3-0.3-0.5-0.2-2.0
Number of responses in last shaping day1.71.82.9-1.61.1-1.7-1.1-1.21.3-1.61.3-0.90.9-1.6-1.7-1.1