Hub : Genes

Adrb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Adrb1 0.16 0.07 0.0e+00 0.15 0.17 0.17 0.17 9.6e-22 2.3e-25 1.5e-25 3.1e-25
2 pVTA gene expression Adrb1 0.07 0.04 7.1e-07 0.09 0.08 0.07 0.09 8.7e-08 7.0e-07 3.1e-06 1.6e-07
3 IC gene expression Adrb1 0.08 0.05 2.7e-03 0.02 0.06 0.01 0.06 6.5e-02 1.1e-03 1.3e-01 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.71.22.6-1.00.1-1.6
Area under the delay curve0.20.20.7-0.2-0.1-0.8
BMI with tail3.913.627.8-5.33.5-0.6
BMI without tail2.88.517.7-4.22.80.1
Body weight3.515.333.2-5.83.3-1.4
Weight adjusted by age5.17.713.0-3.63.10.8
Bone surface0.20.40.8-0.60.1-0.9
Bone volume0.81.42.6-1.60.6-1.1
Breakpoint value in progressive ratio session0.20.30.60.2-0.4-0.7
Number of licking bursts0.40.61.20.3-0.7-1.1
Context. condit. distance diff. score0.70.91.51.2-1.10.4
Locomotion velocity, session 10.00.00.00.10.20.2
Locomotion distance, session 11.11.42.4-0.91.11.5
Locomotion velocity, session 21.51.83.9-0.71.02.0
Locomotion distance, session 22.02.82.9-1.61.71.6
Locomotion velocity, session 31.31.52.4-0.91.11.6
Locomotion distance, session 31.71.94.0-0.81.02.0
Stereotopy head waving bouts, day 30.10.10.2-0.40.3-0.0
Stereotopy head waving duration, day 30.20.30.80.2-0.2-0.9
Locomotion velocity, session 70.10.10.2-0.30.5-0.3
Locomotion distance, session 70.00.10.10.30.20.2
Stereotopy head waving bouts, day 70.00.00.0-0.10.1-0.1
Stereotopy head waving duration, day 70.30.40.6-0.80.5-0.6
Locomotion velocity, session 81.31.52.31.5-1.50.2
Locomotion distance, session 80.60.92.00.7-0.41.4
Degree of sensitization distance2.82.83.21.7-1.6-1.8
Degree of sensitization stereotypy0.10.10.20.1-0.1-0.5
Conditioned locomotion0.10.10.20.20.20.5
Cocaine response after cond. corrected1.21.43.80.60.22.0
Cocaine response after cond. not corrected0.91.12.21.0-0.31.5
Cocaine response before conditioning1.21.42.00.9-1.2-1.4
Saline control response0.40.51.3-0.10.51.1
Bone: connectivity density0.30.51.10.2-0.6-1.1
Bone: cortical apparent density2.23.07.4-0.41.22.7
Bone: cortical area3.96.011.4-3.42.5-0.7
Bone: cortical porosity0.20.20.40.6-0.5-0.3
Bone: cortical porosity0.40.50.80.5-0.7-0.9
Bone: cortical thickness2.74.57.8-2.82.40.2
Bone: cortical thickness1.92.23.4-1.81.60.7
Bone: cortical tissue density2.02.87.2-0.21.02.7
Condit. Reinf. active minus inactive responses0.20.20.4-0.20.40.7
Condit. Reinf. active-inactive response ratio0.00.00.00.10.00.2
Condit. Reinf. active responses0.70.81.3-1.11.10.3
Condit. Reinf. inactive responses1.01.22.1-1.41.2-0.2
Incentive salience index mean0.40.41.0-0.00.61.0
Condit. Reinf. lever presses0.20.30.50.10.70.7
Condit. Reinf. active minus inactive responses1.01.33.0-0.90.4-1.7
Condit. Reinf. active-inactive response ratio0.40.51.4-0.20.2-1.2
Condit. Reinf. active responses1.42.03.9-1.30.5-2.0
Condit. Reinf. inactive responses0.50.71.3-0.90.0-1.2
Condit. Reinf. lever presses0.30.41.0-0.5-0.1-1.0
Condit. Reinf. lever reinforcers received1.01.42.7-1.10.4-1.7
Conditioned reinforcement - actives0.91.52.1-0.71.41.5
Conditioned reinforcement - inactives0.20.40.6-0.70.70.0
Conditioned locomotion2.33.04.8-1.01.72.2
Patch foraging indifference point 0 sec1.32.44.9-2.21.4-0.7
Patch foraging indifference point AUC0.20.30.90.3-0.1-0.9
Delay disc. indifference point, 0s delay0.10.10.1-0.40.40.2
Delay disc. indifference point, 16s delay0.30.40.70.4-0.6-0.8
Delay disc. indifference point, 2s delay0.20.30.60.8-0.4-0.0
Delay disc. indifference point, 24s delay1.31.42.90.5-1.1-1.7
Delay disc. indifference point, 4s delay0.40.40.60.7-0.6-0.5
Delay disc. indifference point, 8s delay1.92.24.2-2.11.4-0.6
Indifference point function ln k0.10.10.1-0.40.20.4
Indifference point function log k0.10.10.1-0.40.20.4
Patch foraging total patch changes 0 sec1.22.24.3-2.11.2-0.9
Patch foraging total patch changes 12 sec0.40.61.5-0.4-0.1-1.2
Patch foraging total patch changes 18 sec0.91.42.3-1.20.5-1.5
Patch foraging total patch changes 24 sec0.50.92.1-0.80.3-1.4
Patch foraging total patch changes 6 sec1.72.65.4-2.31.2-1.0
Patch foraging time to switch 0 sec0.20.40.60.8-0.50.6
Patch foraging water rate 0 sec0.30.61.1-1.10.7-0.5
Patch foraging water rate 12 sec0.51.12.5-0.80.4-1.6
Patch foraging water rate 18 sec0.91.42.2-1.31.50.7
Patch foraging water rate 24 sec1.01.41.9-1.41.30.7
Patch foraging water rate 6 sec0.60.81.2-1.11.00.6
Seeking ratio, delayed vs. immediate footshock0.30.41.00.50.01.0
Distance traveled before self-admin0.91.23.40.10.51.8
Distance traveled after self-admin1.62.05.0-0.31.02.2
Extensor digitorum longus weight0.20.71.8-0.40.2-1.3
Bone: elastic displacement0.10.10.20.3-0.5-0.3
Bone: elastic work1.51.92.2-1.51.41.2
Bone: endosteal estimation0.51.02.0-1.40.8-0.7
Bone: endosteal perimeter2.45.110.2-3.22.3-0.3
Epididymis fat weight3.612.222.9-4.82.2-3.0
Delta time in closed arm before/after self-admin0.40.41.1-0.10.41.0
Delta time in open arm before/after self-admin0.40.41.1-0.40.1-1.1
Diff in mean of infusions in LGA sessions1.11.31.81.4-1.3-0.6
Delay discount exponential model param0.20.30.70.10.10.9
Extinction: sum of active levers before priming1.01.11.41.1-1.2-0.8
Active lever presses in extinction session 60.10.10.2-0.4-0.20.4
Bone: final force2.03.25.1-2.32.10.4
Bone: final moment1.93.04.8-2.22.00.3
Food consumed during 24 hour testing period0.20.30.60.3-0.80.3
Glucose1.11.83.6-1.91.30.1
Heart weight0.91.32.6-1.60.9-0.8
Delay discount hyperbolic model param0.10.10.40.10.00.7
Intermittent access intake day 1-15 change1.22.43.7-1.91.61.0
Intermittent access intake escalation0.81.63.0-1.71.20.6
Intermittent access intake escalation 21.61.82.3-1.51.31.2
Intermitt. access day 1 inactive lever presses0.31.02.7-0.5-0.1-1.6
Intermitt. access day 15 inactive lever presses0.00.00.0-0.10.1-0.2
Intermitt. access escalation Index0.00.00.10.1-0.30.0
Intermittent access day 1 total infusions0.40.61.1-0.51.00.7
Intermittent access day 15 total infusions0.71.01.3-1.01.20.8
Intermittent access terminal intake (last 3 days)0.50.60.9-0.60.90.7
Intermittent access total infusions1.51.72.8-1.31.70.8
Intermittent access day 1 locomotion0.91.21.7-0.61.21.3
Intermittent access day 15 total locomotion1.12.03.7-1.91.5-0.2
Intermittent access total locomotion2.63.14.3-1.62.11.5
Intermittent access standard deviation0.10.30.6-0.80.5-0.4
Left kidney weight1.15.37.6-2.82.41.5
Right kidney weight2.611.717.6-4.23.72.0
Cocaine induced anxiety2.13.05.72.4-1.41.1
Post-drug Anxiety1.11.21.91.2-1.4-0.4
Baseline Anxiety1.51.72.7-1.50.3-1.7
Tail length0.00.10.4-0.6-0.0-0.1
Length with tail0.41.74.0-2.00.8-0.7
Length without tail1.24.07.8-2.81.3-1.5
Times rat made contact with spout0.30.40.6-0.60.50.8
Lifetime Intake1.82.13.2-1.51.81.0
Liver weight, left1.32.24.9-2.21.0-0.7
Liver weight, right4.07.010.1-3.23.01.5
Locomotor activity1.42.13.6-1.91.40.9
Locomotor testing distance2.24.05.3-2.31.91.7
Locomotor testing rearing0.71.52.0-1.41.11.2
Locomotion in novel chamber1.11.33.8-0.10.52.0
Locomotion in novel chamber post-restriction0.61.02.30.50.71.5
Fecal boli incidents, locomotor time 10.60.81.2-1.11.0-0.6
Change in fecal boli incidents, locomotor task2.12.13.21.8-1.70.1
Time >=10cm from walls, locomotor time 11.21.21.91.4-1.3-0.2
Bouts of movement, locomotor time 10.50.51.4-0.40.2-1.2
Total resting periods, locomotor time 10.30.30.6-0.40.4-0.8
Rest time, locomotor task time 10.91.11.6-0.81.31.0
Distance moved, locomotor task time 10.30.51.00.3-1.0-0.6
Vertical activity count, locomotor time 10.20.61.30.6-1.10.1
Time >=10cm from walls, locomotor time 20.40.60.80.4-0.9-0.9
Bouts of movement, locomotor time 20.91.43.21.8-0.9-0.1
Total resting periods, locomotor time 20.40.81.91.4-0.7-0.0
Rest time, locomotor task time 20.30.30.5-0.70.50.5
Distance moved, locomotor task time 20.20.20.6-0.0-0.2-0.8
Vertical activity count, locomotor time 20.10.10.2-0.2-0.2-0.5
Light reinforcement 10.51.32.81.7-1.10.3
Light reinforcement 21.01.53.01.7-1.00.8
Bone: marrow area0.51.12.0-1.40.8-0.7
Bone: maximum diameter2.95.410.8-3.31.9-1.3
Bone: maximum force1.52.64.3-2.11.80.4
Bone: maximum moment1.32.23.8-2.01.60.2
Mean time between licks in bursts0.20.40.60.5-0.7-0.8
Mean num. licks in bursts1.42.23.6-1.11.41.9
Cd content in liver1.11.23.50.00.41.9
Co content in liver0.40.50.9-0.10.90.8
Cu content in liver0.10.10.20.2-0.00.5
Fe content in liver0.70.92.5-0.2-0.3-1.6
K content in liver0.20.20.60.7-0.4-0.1
Mg content in liver0.50.50.80.9-0.9-0.2
Mn content in liver0.60.61.00.9-1.0-0.1
Na content in liver0.60.71.11.1-0.8-0.6
Rb content in liver3.13.64.82.2-2.2-1.1
Se content in liver0.60.71.00.9-1.0-0.4
Sr content in liver0.90.81.50.8-0.41.2
Zn content in liver0.50.60.91.0-0.70.7
Bone: minimum diameter1.01.83.3-1.80.9-1.1
Time in familiar zone, hab. session 10.20.20.3-0.30.60.4
Time in novel zone, hab. session 10.40.40.9-0.1-0.5-0.9
Total zone transitions, hab. session 11.42.02.8-1.71.31.1
Total locomotion distance, hab. session 10.10.10.20.2-0.50.3
Locomotion velocity, hab. session 10.20.20.30.4-0.50.5
Time in familiar zone, hab. session 20.91.02.7-0.4-0.2-1.7
Time in novel zone, hab. session 21.21.22.9-0.30.81.7
Total zone transitions, hab. session 21.62.03.1-1.81.41.0
Total locomotion distance, hab. session 20.30.40.6-0.70.40.8
Locomotion velocity, hab. session 20.20.30.6-0.50.20.8
Novel to familiar place preference ratio0.30.40.60.3-0.7-0.8
Novelty place preference0.20.20.50.1-0.5-0.7
Time in novel zone, NPP test0.40.41.1-0.1-0.4-1.1
Total zone transitions, NPP test0.40.60.8-0.90.50.8
Total locomotion distance, NPP test0.10.10.3-0.1-0.30.5
Locomotion velocity, NPP test0.30.41.00.1-0.41.0
Intraocular pressure2.13.05.3-2.31.8-0.7
Delta distance traveled before/after self-admin0.20.20.5-0.40.30.7
Delta ambulatory time before/after self-admin0.00.00.1-0.2-0.1-0.2
Parametrial fat weight4.410.317.0-4.12.6-2.7
Pavlov. Cond. lever latency0.20.30.8-0.0-0.4-0.9
Pavlov. Cond. magazine entry latency0.10.10.2-0.10.20.5
Pavlov. Cond. change in total contacts0.10.10.2-0.20.20.4
Pavlov. Cond. index score0.20.30.4-0.40.40.6
Pavlov. Cond. latency score0.20.30.4-0.40.50.7
Pavlov. Cond. lever contacts0.10.10.2-0.10.40.5
Pavlov. Cond. magazine entry number0.70.91.21.1-1.0-0.7
Pavlov. Cond. intertrial magazine entries0.30.40.6-0.70.70.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.30.20.4
Pavlov. Cond. response bias0.30.30.6-0.30.50.8
Pavlov. Cond. lever latency0.30.41.20.10.31.1
Pavlov. Cond. magazine entry latency0.20.30.6-0.5-0.2-0.8
Pavlov. Cond. change in total contacts0.30.51.1-0.50.0-1.1
Pavlov. Cond. index score0.30.40.7-0.70.2-0.9
Pavlov. Cond. latency score0.30.40.8-0.70.1-0.9
Pavlov. Cond. lever contacts0.10.10.4-0.30.0-0.6
Pavlov. Cond. magazine entry number0.20.20.50.50.10.7
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.0-0.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.90.4-0.6
Pavlov. Cond. response bias0.30.40.9-0.5-0.0-0.9
Time in closed arm before self-admin0.10.10.30.5-0.3-0.2
Time in closed arm after self-admin0.60.61.01.0-0.20.9
Time in open arm before self-admin1.01.11.81.3-1.3-0.0
Time in open arm after self-admin0.20.20.4-0.20.3-0.6
Bone: periosteal estimation2.24.58.8-3.02.1-0.6
Bone: periosteal perimeter5.08.616.1-4.03.1-0.6
Bone: post-yield work0.60.81.01.0-1.0-0.7
Progressive ratio test 1 active lever presses1.21.52.2-1.11.51.1
Progressive ratio test 1 breakpoint1.31.62.4-1.11.51.1
Progressive ratio test 1 inactive lever presses0.10.10.1-0.40.30.1
Progressive ratio test 2 active lever presses1.61.92.9-1.71.50.7
Progressive ratio test 2 breakpoint1.71.93.1-1.71.50.6
Progressive ratio test 2 inactive lever presses0.60.91.4-1.11.2-0.3
Incentive Sensitization - Responses0.50.71.3-1.10.8-0.3
Incentive Sensitization - Breakpoint0.50.61.3-1.10.7-0.3
Sum of active levers in priming session hrs 5-60.30.30.60.7-0.4-0.3
Progressive ratio0.30.40.80.7-0.9-0.1
Food seeking constrained by brief footshock1.92.43.81.2-1.9-1.3
Seeking ratio, punishment vs. effort0.00.00.0-0.10.1-0.2
Retroperitoneal fat weight3.816.229.3-5.42.9-3.3
Reaction time number correct0.20.40.7-0.70.4-0.8
Reaction time mean minus median0.51.21.6-1.31.10.8
Reaction time mean minus median AUC0.82.12.2-1.31.51.5
Reaction time num false alarms0.00.00.00.10.10.1
Reaction time num false alarms AUC0.10.10.2-0.20.30.4
Reaction time trials correct on left0.20.40.7-0.70.4-0.8
Reaction time trials on left0.20.50.7-0.70.4-0.8
Reaction time mean0.81.21.5-1.21.20.9
Reaction time mean AUC0.40.60.8-0.70.90.7
Median of all reaction times0.81.11.4-1.11.20.9
Reaction time omissions0.10.20.2-0.40.3-0.5
Reaction time false alarm rate0.10.10.30.3-0.10.5
Reaction time premature initiation rate1.72.32.8-1.21.71.6
Reaction time premature initiations1.62.93.9-1.72.01.3
Std. dev. reaction times1.42.74.2-2.11.80.7
Reaction time trials completed0.20.50.7-0.70.4-0.8
Reaction time trials AUC0.30.50.7-0.80.5-0.8
Run reversals in cocaine runway, females2.12.12.8-1.71.61.0
Run reversals in cocaine runway, males2.02.03.11.8-1.6-0.6
Latency to leave start box in cocaine runway0.80.91.81.0-1.40.1
Latency to leave start box in cocaine runway, F1.11.32.31.2-1.5-0.0
Latency to leave start box in cocaine runway, M0.00.00.1-0.1-0.20.1
Std. dev. time between licks in bursts0.30.40.70.8-0.5-0.6
Total sessions with >9 infusions3.64.46.6-2.62.31.1
Short access day 1 total inactive lever presses0.40.61.20.4-1.1-0.6
Short access day 10 total inactive lever presses0.10.20.5-0.70.2-0.0
Short access day 1 total infusions0.71.01.1-1.00.81.0
Short access day 10 total infusions1.21.52.1-0.91.31.4
Short access total infusions2.12.63.2-1.51.81.6
Short access day 1 locomotion0.81.01.2-1.11.10.8
Short access day 10 total locomotion1.12.12.9-1.51.71.0
Short access total locomotion3.13.75.1-1.82.31.7
One hour access (0.3 mA shock)0.30.30.4-0.60.2-0.7
Compulsive drug intake1.21.41.70.9-1.3-1.3
One hour access (shock baseline)1.11.62.1-1.41.40.9
Social response proportion4.04.65.0-2.22.22.0
Social responses2.93.87.3-2.72.00.1
Social time1.82.43.3-1.81.71.1
Soleus weight2.67.712.0-3.53.11.1
Bone: stiffness1.22.03.0-1.71.60.5
Tibialis anterior weight0.20.71.90.30.1-1.4
Time to tail flick, vehicle, before self-admin0.30.30.7-0.80.3-0.3
Time to tail flick, vehicle, after self-admin0.30.40.60.6-0.8-0.5
Time to tail flick, test, before self-admin4.24.36.6-1.32.22.6
Time to tail flick, test, after self-admin0.30.30.5-0.70.5-0.3
Delta time to tail flick, vehicle, before/after SA0.70.60.90.6-0.8-0.9
Delta time to tail flick, test, before/after SA0.50.61.4-0.5-0.1-1.2
Tibia length1.64.36.4-2.52.31.2
Ambulatory time before self-admin1.21.73.3-0.81.11.8
Ambulatory time after self-admin1.61.83.8-0.71.12.0
Bone: tissue strength0.40.40.50.7-0.7-0.4
Total heroin consumption0.50.51.0-1.00.3-0.8
Bone: trabecular number0.71.23.3-0.1-0.6-1.8
Bone: trabecular spacing0.10.20.30.6-0.5-0.1
Bone: trabecular thickness1.82.34.2-2.11.0-1.3
Bone: trabecular tissue density1.11.71.8-1.31.31.3
Water consumed over 24 hours0.50.70.9-0.80.71.0
Number of responses in last shaping day0.80.91.8-0.51.30.8