Hub : Genes

Adrb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Adrb1 0.12 0.06 1.2e-15 0.07 0.1 0.1 0.1 1.5e-08 1.1e-11 8.1e-12 4.2e-11
2 pVTA gene expression Adrb1 0.12 0.07 1.2e-05 0.17 0.12 0.12 0.14 9.9e-08 7.7e-06 5.9e-06 1.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.20.30.70.8-0.0
Area under the delay curve0.10.10.10.3-0.3
BMI with tail5.618.125.65.1-3.3
BMI without tail2.04.16.52.5-1.3
Body weight5.723.734.85.9-3.5
Weight adjusted by age8.09.010.33.2-2.8
Bone surface0.20.30.50.70.0
Bone volume0.81.42.51.6-0.6
Breakpoint value in progressive ratio session1.31.42.1-0.91.4
Number of licking bursts0.10.10.2-0.10.5
Context. condit. distance diff. score0.81.01.0-1.01.0
Locomotion velocity, session 10.10.10.1-0.3-0.3
Locomotion distance, session 11.31.72.70.8-1.6
Locomotion velocity, session 21.11.32.00.7-1.4
Locomotion distance, session 22.73.84.71.7-2.2
Locomotion velocity, session 31.21.32.10.8-1.4
Locomotion distance, session 31.41.62.40.8-1.6
Stereotopy head waving bouts, day 30.10.10.10.3-0.2
Stereotopy head waving duration, day 30.20.20.2-0.40.5
Locomotion velocity, session 70.10.10.10.3-0.3
Locomotion distance, session 70.00.00.0-0.20.0
Stereotopy head waving bouts, day 70.00.00.00.10.1
Stereotopy head waving duration, day 70.30.40.60.7-0.4
Locomotion velocity, session 81.61.92.3-1.51.2
Locomotion distance, session 80.00.10.1-0.4-0.0
Degree of sensitization distance3.73.74.9-1.62.2
Degree of sensitization stereotypy0.00.00.0-0.00.2
Conditioned locomotion0.00.00.0-0.1-0.2
Cocaine response after cond. corrected0.20.20.3-0.6-0.1
Cocaine response after cond. not corrected0.60.71.1-1.00.5
Cocaine response before conditioning1.21.51.9-1.11.4
Saline control response0.20.30.40.4-0.6
Bone: connectivity density0.20.30.5-0.30.7
Bone: cortical apparent density1.31.82.70.9-1.6
Bone: cortical area5.78.611.73.4-2.3
Bone: cortical porosity0.10.10.1-0.30.4
Bone: cortical porosity0.30.30.5-0.30.7
Bone: cortical thickness3.96.58.12.8-2.2
Bone: cortical thickness2.63.03.61.9-1.6
Bone: cortical tissue density1.01.32.20.7-1.5
Condit. Reinf. active minus inactive responses0.10.10.10.2-0.4
Condit. Reinf. active-inactive response ratio0.00.00.0-0.20.1
Condit. Reinf. active responses0.81.01.20.9-1.1
Condit. Reinf. inactive responses1.21.51.71.1-1.3
Incentive salience index mean0.20.20.4-0.0-0.6
Condit. Reinf. lever presses0.20.30.6-0.0-0.8
Condit. Reinf. active minus inactive responses0.10.20.20.4-0.4
Condit. Reinf. active-inactive response ratio0.00.00.0-0.1-0.1
Condit. Reinf. active responses0.50.71.01.0-0.7
Condit. Reinf. inactive responses0.30.40.60.8-0.3
Condit. Reinf. lever presses0.00.00.00.20.1
Condit. Reinf. lever reinforcers received0.30.40.50.7-0.6
Conditioned reinforcement - actives0.80.81.50.3-1.2
Conditioned reinforcement - inactives0.50.50.60.8-0.7
Conditioned locomotion0.50.61.20.1-1.1
Patch foraging indifference point 0 sec2.33.75.72.4-1.3
Patch foraging indifference point AUC0.00.00.0-0.10.0
Delay disc. indifference point, 0s delay0.20.20.30.6-0.3
Delay disc. indifference point, 16s delay0.20.20.3-0.50.3
Delay disc. indifference point, 2s delay0.10.10.2-0.40.4
Delay disc. indifference point, 24s delay0.40.40.5-0.50.7
Delay disc. indifference point, 4s delay0.50.50.6-0.80.6
Delay disc. indifference point, 8s delay3.13.23.71.9-1.6
Indifference point function ln k0.20.30.40.6-0.5
Indifference point function log k0.20.30.40.6-0.5
Patch foraging total patch changes 0 sec2.03.24.82.2-1.2
Patch foraging total patch changes 12 sec0.10.10.20.40.2
Patch foraging total patch changes 18 sec0.60.81.21.1-0.6
Patch foraging total patch changes 24 sec0.20.20.40.6-0.0
Patch foraging total patch changes 6 sec2.13.24.82.2-1.3
Patch foraging time to switch 0 sec0.30.50.5-0.70.7
Patch foraging water rate 0 sec0.50.81.11.0-0.7
Patch foraging water rate 12 sec0.10.20.30.50.1
Patch foraging water rate 18 sec1.01.31.71.3-1.0
Patch foraging water rate 24 sec1.42.02.51.6-1.2
Patch foraging water rate 6 sec0.71.01.21.1-0.9
Seeking ratio, delayed vs. immediate footshock0.10.10.1-0.30.1
Distance traveled before self-admin0.20.20.30.2-0.5
Distance traveled after self-admin1.11.31.70.9-1.3
Extensor digitorum longus weight0.10.20.50.7-0.1
Bone: elastic displacement0.20.20.3-0.50.4
Bone: elastic work1.72.22.21.5-1.5
Bone: endosteal estimation0.61.32.01.4-0.7
Bone: endosteal perimeter3.57.39.53.1-2.3
Epididymis fat weight7.617.726.35.1-3.0
Delta time in closed arm before/after self-admin0.10.10.10.2-0.3
Delta time in open arm before/after self-admin0.00.00.0-0.1-0.0
Diff in mean of infusions in LGA sessions5.86.46.9-2.42.6
Delay discount exponential model param0.10.10.1-0.30.3
Extinction: sum of active levers before priming1.71.71.7-1.31.3
Active lever presses in extinction session 60.00.00.00.10.0
Bone: final force2.74.45.42.3-1.8
Bone: final moment2.64.35.52.3-1.8
Food consumed during 24 hour testing period0.00.00.1-0.10.3
Glucose3.75.67.32.7-2.0
Heart weight2.63.74.12.0-1.8
Delay discount hyperbolic model param0.00.00.0-0.20.2
Intermittent access intake day 1-15 change2.01.93.21.8-0.8
Intermittent access intake escalation4.64.55.92.4-1.8
Intermittent access intake escalation 22.92.93.31.8-1.5
Intermitt. access day 1 inactive lever presses0.30.30.70.8-0.1
Intermitt. access day 15 inactive lever presses0.00.10.10.3-0.2
Intermitt. access escalation Index0.00.00.00.1-0.1
Intermittent access day 1 total infusions0.20.20.4-0.0-0.6
Intermittent access day 15 total infusions1.21.41.41.2-1.2
Intermittent access terminal intake (last 3 days)0.70.80.80.9-0.9
Intermittent access total infusions1.51.62.11.1-1.5
Intermittent access day 1 locomotion0.30.30.6-0.1-0.8
Intermittent access day 15 total locomotion1.82.02.61.6-1.2
Intermittent access total locomotion1.41.62.01.1-1.4
Intermittent access standard deviation0.10.10.10.4-0.2
Left kidney weight4.512.614.03.7-3.4
Right kidney weight7.119.821.84.7-4.2
Cocaine induced anxiety3.33.94.7-2.21.7
Post-drug Anxiety0.70.80.9-0.90.8
Baseline Anxiety3.43.64.82.2-1.6
Tail length0.00.10.10.30.3
Length with tail1.45.07.12.7-1.7
Length without tail4.18.911.63.4-2.5
Times rat made contact with spout0.80.90.90.9-0.9
Lifetime Intake1.92.12.91.2-1.7
Liver weight, left1.82.94.42.1-1.2
Liver weight, right4.77.811.13.3-2.1
Locomotor activity2.03.24.32.1-1.4
Locomotor testing distance3.66.07.22.7-2.2
Locomotor testing rearing1.11.72.61.6-0.8
Locomotion in novel chamber0.40.50.80.3-0.9
Locomotion in novel chamber post-restriction0.20.20.5-0.2-0.7
Fecal boli incidents, locomotor time 10.40.40.40.7-0.6
Change in fecal boli incidents, locomotor task2.32.22.3-1.51.4
Time >=10cm from walls, locomotor time 11.81.82.0-1.41.2
Bouts of movement, locomotor time 10.00.00.00.20.1
Total resting periods, locomotor time 10.00.00.10.2-0.0
Rest time, locomotor task time 10.80.81.10.7-1.1
Distance moved, locomotor task time 10.10.10.2-0.30.4
Vertical activity count, locomotor time 10.40.50.5-0.60.7
Time >=10cm from walls, locomotor time 20.60.61.0-0.61.0
Bouts of movement, locomotor time 22.02.22.7-1.61.3
Total resting periods, locomotor time 21.01.11.5-1.20.9
Rest time, locomotor task time 20.50.60.70.7-0.8
Distance moved, locomotor task time 20.00.00.0-0.10.0
Vertical activity count, locomotor time 20.00.00.10.10.3
Light reinforcement 11.01.92.6-1.61.1
Light reinforcement 21.31.82.8-1.70.9
Bone: marrow area0.61.32.11.4-0.7
Bone: maximum diameter3.86.99.93.1-2.0
Bone: maximum force2.64.55.72.4-1.8
Bone: maximum moment2.54.35.52.4-1.7
Mean time between licks in bursts0.20.30.5-0.30.7
Mean num. licks in bursts1.51.82.21.2-1.5
Cd content in liver2.52.83.5-1.91.4
Co content in liver0.10.10.20.2-0.4
Cu content in liver0.20.20.20.5-0.5
Fe content in liver0.00.00.0-0.10.1
K content in liver0.80.81.0-1.00.7
Mg content in liver0.80.80.8-0.90.9
Mn content in liver1.11.21.3-1.11.1
Na content in liver1.51.61.9-1.11.4
Rb content in liver3.44.34.4-2.02.1
Se content in liver0.30.30.4-0.60.5
Sr content in liver0.60.60.7-0.80.7
Zn content in liver0.91.01.1-1.00.9
Bone: minimum diameter1.32.44.02.0-0.9
Time in familiar zone, hab. session 10.10.10.20.3-0.4
Time in novel zone, hab. session 10.10.10.10.10.3
Total zone transitions, hab. session 12.43.33.41.9-1.8
Total locomotion distance, hab. session 10.00.00.00.1-0.1
Locomotion velocity, hab. session 10.00.00.0-0.1-0.1
Time in familiar zone, hab. session 20.10.10.10.20.3
Time in novel zone, hab. session 20.70.71.10.5-1.1
Total zone transitions, hab. session 22.32.93.01.7-1.7
Total locomotion distance, hab. session 20.60.80.90.9-0.8
Locomotion velocity, hab. session 20.30.40.50.7-0.6
Novel to familiar place preference ratio0.20.20.2-0.40.4
Novelty place preference0.10.10.1-0.20.3
Time in novel zone, NPP test0.00.00.1-0.10.3
Total zone transitions, NPP test0.81.11.21.1-1.0
Total locomotion distance, NPP test0.10.10.20.5-0.2
Locomotion velocity, NPP test0.00.00.10.3-0.2
Intraocular pressure2.43.43.92.0-1.7
Delta distance traveled before/after self-admin0.70.80.80.9-0.9
Delta ambulatory time before/after self-admin0.20.20.20.5-0.4
Parametrial fat weight2.85.48.83.0-1.4
Pavlov. Cond. lever latency0.10.10.2-0.10.5
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.3
Pavlov. Cond. change in total contacts0.00.00.00.2-0.1
Pavlov. Cond. index score0.20.20.20.4-0.5
Pavlov. Cond. latency score0.20.20.30.4-0.5
Pavlov. Cond. lever contacts0.10.10.1-0.0-0.4
Pavlov. Cond. magazine entry number0.91.11.2-1.11.0
Pavlov. Cond. intertrial magazine entries0.50.60.60.7-0.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.2-0.3
Pavlov. Cond. response bias0.40.40.60.5-0.8
Pavlov. Cond. lever latency0.10.10.10.2-0.3
Pavlov. Cond. magazine entry latency0.10.20.30.6-0.1
Pavlov. Cond. change in total contacts0.00.10.10.3-0.2
Pavlov. Cond. index score0.20.30.40.6-0.3
Pavlov. Cond. latency score0.10.20.30.5-0.2
Pavlov. Cond. lever contacts0.00.00.10.3-0.0
Pavlov. Cond. magazine entry number0.10.20.3-0.60.2
Pavlov. Cond. intertrial magazine entries0.00.00.00.10.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.60.7-0.5
Pavlov. Cond. response bias0.10.10.20.5-0.1
Time in closed arm before self-admin0.10.10.10.20.3
Time in closed arm after self-admin0.20.20.3-0.40.5
Time in open arm before self-admin2.02.22.3-1.51.5
Time in open arm after self-admin0.70.81.1-1.10.6
Bone: periosteal estimation3.16.39.13.0-1.9
Bone: periosteal perimeter7.412.215.74.0-3.0
Bone: post-yield work0.40.50.6-0.60.8
Progressive ratio test 1 active lever presses1.81.92.41.2-1.6
Progressive ratio test 1 breakpoint0.80.91.30.7-1.1
Progressive ratio test 1 inactive lever presses0.00.10.10.2-0.3
Progressive ratio test 2 active lever presses3.33.63.91.8-2.0
Progressive ratio test 2 breakpoint2.62.93.01.7-1.7
Progressive ratio test 2 inactive lever presses0.60.70.70.8-0.9
Incentive Sensitization - Responses1.21.21.61.3-1.0
Incentive Sensitization - Breakpoint1.21.21.61.3-0.9
Sum of active levers in priming session hrs 5-62.32.33.0-1.71.3
Progressive ratio0.50.60.9-0.90.5
Food seeking constrained by brief footshock2.02.52.8-1.51.7
Seeking ratio, punishment vs. effort0.00.00.10.00.3
Retroperitoneal fat weight7.524.635.96.0-3.7
Reaction time number correct0.20.30.50.7-0.1
Reaction time mean minus median0.91.21.21.1-1.1
Reaction time mean minus median AUC1.31.71.91.4-1.2
Reaction time num false alarms0.00.00.0-0.10.0
Reaction time num false alarms AUC0.00.10.10.2-0.3
Reaction time trials correct on left0.20.30.50.7-0.1
Reaction time trials on left0.20.30.60.8-0.1
Reaction time mean0.91.21.21.1-1.1
Reaction time mean AUC0.30.40.40.6-0.7
Median of all reaction times0.81.11.11.1-1.1
Reaction time omissions0.10.20.30.5-0.3
Reaction time false alarm rate0.10.10.2-0.40.0
Reaction time premature initiation rate1.92.53.01.4-1.7
Reaction time premature initiations2.83.93.92.0-2.0
Std. dev. reaction times2.23.13.41.8-1.7
Reaction time trials completed0.20.30.60.8-0.1
Reaction time trials AUC0.30.40.70.8-0.2
Run reversals in cocaine runway, females1.41.41.51.2-1.1
Run reversals in cocaine runway, males3.02.93.2-1.81.6
Latency to leave start box in cocaine runway0.40.40.6-0.80.5
Latency to leave start box in cocaine runway, F0.40.50.7-0.80.5
Latency to leave start box in cocaine runway, M0.10.10.10.4-0.4
Std. dev. time between licks in bursts0.50.60.6-0.70.8
Total sessions with >9 infusions9.110.110.63.1-3.3
Short access day 1 total inactive lever presses0.10.10.10.4-0.3
Short access day 10 total inactive lever presses0.40.50.80.9-0.4
Short access day 1 total infusions1.51.61.81.2-1.4
Short access day 10 total infusions0.80.81.40.5-1.2
Short access total infusions1.61.82.80.9-1.7
Short access day 1 locomotion1.11.21.51.0-1.2
Short access day 10 total locomotion0.70.70.90.9-0.8
Short access total locomotion2.52.63.51.3-1.9
One hour access (0.3 mA shock)0.30.40.50.7-0.5
Compulsive drug intake0.90.91.1-1.00.9
One hour access (shock baseline)2.42.83.11.8-1.6
Social response proportion5.25.76.02.5-2.3
Social responses4.25.46.52.6-2.1
Social time2.33.13.71.9-1.5
Soleus weight3.911.314.43.8-2.9
Bone: stiffness2.23.54.32.1-1.6
Tibialis anterior weight0.00.00.1-0.30.0
Time to tail flick, vehicle, before self-admin1.11.11.61.3-0.8
Time to tail flick, vehicle, after self-admin0.70.70.80.9-0.8
Time to tail flick, test, before self-admin4.03.94.51.8-2.1
Time to tail flick, test, after self-admin1.61.62.51.6-0.9
Delta time to tail flick, vehicle, before/after SA0.00.00.00.1-0.1
Delta time to tail flick, test, before/after SA0.40.30.60.8-0.1
Tibia length2.05.77.12.7-2.1
Ambulatory time before self-admin0.50.50.60.7-0.8
Ambulatory time after self-admin0.91.01.01.0-1.0
Bone: tissue strength0.50.50.5-0.70.7
Total heroin consumption0.10.10.10.20.4
Bone: trabecular number0.10.20.4-0.10.6
Bone: trabecular spacing0.10.20.2-0.40.4
Bone: trabecular thickness2.32.74.22.1-1.1
Bone: trabecular tissue density1.72.32.51.6-1.5
Water consumed over 24 hours0.70.81.01.0-0.8
Number of responses in last shaping day0.80.81.10.7-1.1