Hub : Genes

Zfp513

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Zfp513	0.06	0.06	1.9e-04	0.03	0.03	0.02	0.03	2.6e-04	3.9e-04	2.4e-03	3.0e-04
2	NAcc	gene expression	Zfp513	0.05	0.04	1.3e-06	0.05	0.05	0.04	0.05	4.7e-06	1.8e-06	5.5e-06	2.9e-06
3	BLA	gene expression	Zfp513	0.09	0.09	9.1e-04	0.04	0.04	0.02	0.04	2.3e-03	2.5e-03	2.1e-02	2.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	5.0	8.4	9.7	3.1	-3.0	2.5
Area under the delay curve	0.0	0.0	0.0	-0.1	-0.2	-0.2
BMI with tail	0.3	1.1	1.3	-1.0	1.1	-1.1
BMI without tail	0.2	0.3	0.5	-0.7	0.6	-0.4
Body weight	1.8	7.6	8.2	-2.9	2.8	-2.6
Weight adjusted by age	0.0	0.0	0.1	0.1	-0.0	0.2
Bone surface	2.5	4.4	5.7	2.4	-2.2	1.6
Bone volume	2.7	4.6	5.8	2.4	-2.2	1.7
Breakpoint value in progressive ratio session	1.1	1.2	1.8	0.8	-1.1	1.3
Number of licking bursts	0.1	0.1	0.3	0.3	-0.2	-0.5
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	0.1	-0.2
Locomotion velocity, session 1	0.0	0.0	0.1	0.0	0.1	-0.3
Locomotion distance, session 1	1.6	2.1	2.8	1.7	-1.6	0.9
Locomotion velocity, session 2	0.3	0.3	0.5	-0.5	0.5	-0.7
Locomotion distance, session 2	0.0	0.0	0.0	0.1	-0.0	-0.2
Locomotion velocity, session 3	0.8	0.9	1.3	0.8	-0.8	1.1
Locomotion distance, session 3	0.9	1.0	1.2	1.1	-1.0	0.9
Stereotopy head waving bouts, day 3	2.1	2.5	3.1	1.5	-1.5	1.8
Stereotopy head waving duration, day 3	0.2	0.2	0.5	0.3	-0.4	0.7
Locomotion velocity, session 7	1.1	1.2	1.4	1.2	-1.1	1.0
Locomotion distance, session 7	0.0	0.1	0.1	0.4	-0.2	0.0
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	0.1	-0.1
Stereotopy head waving duration, day 7	0.4	0.4	0.6	0.6	-0.6	0.8
Locomotion velocity, session 8	0.2	0.2	0.3	0.6	-0.4	0.5
Locomotion distance, session 8	0.2	0.3	0.5	0.7	-0.7	0.2
Degree of sensitization distance	0.8	0.8	0.9	-0.9	0.9	-1.0
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.5	0.4	-0.5
Conditioned locomotion	3.1	3.7	3.8	1.9	-2.0	1.9
Cocaine response after cond. corrected	0.7	0.8	1.1	1.0	-1.0	0.5
Cocaine response after cond. not corrected	1.6	1.8	2.3	1.5	-1.5	0.9
Cocaine response before conditioning	1.3	1.6	1.8	1.2	-1.2	1.3
Saline control response	0.7	0.9	1.2	1.1	-1.0	0.8
Bone: connectivity density	4.8	7.6	8.5	2.9	-2.9	2.4
Bone: cortical apparent density	0.2	0.3	0.4	0.6	-0.7	0.4
Bone: cortical area	0.3	0.4	0.7	0.8	-0.7	0.3
Bone: cortical porosity	1.6	1.8	2.4	1.2	-1.2	1.5
Bone: cortical porosity	1.3	1.4	1.7	1.1	-1.1	1.3
Bone: cortical thickness	0.1	0.2	0.4	-0.1	0.2	-0.7
Bone: cortical thickness	1.4	1.6	1.9	1.4	-1.4	1.0
Bone: cortical tissue density	0.2	0.2	0.3	0.5	-0.6	0.3
Condit. Reinf. active minus inactive responses	0.6	0.7	0.7	-0.8	0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.9	-0.9	0.9	-0.6
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.5	0.1
Condit. Reinf. inactive responses	1.5	1.8	2.2	1.5	-1.5	0.9
Incentive salience index mean	0.0	0.0	0.0	0.1	-0.1	-0.0
Condit. Reinf. lever presses	0.4	0.6	0.8	0.9	-0.9	0.5
Condit. Reinf. active minus inactive responses	4.2	5.2	6.2	2.1	-2.2	2.5
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.2	1.0	-1.0	1.1
Condit. Reinf. active responses	3.4	4.7	5.9	2.0	-2.1	2.4
Condit. Reinf. inactive responses	1.8	2.3	2.7	1.4	-1.5	1.6
Condit. Reinf. lever presses	1.8	2.5	2.8	1.6	-1.7	1.4
Condit. Reinf. lever reinforcers received	3.0	4.3	5.5	1.8	-2.0	2.3
Conditioned reinforcement - actives	1.5	1.5	2.1	1.1	-1.0	1.5
Conditioned reinforcement - inactives	3.3	3.7	3.9	2.0	-1.8	2.0
Conditioned locomotion	0.4	0.5	1.4	0.2	-0.3	1.2
Patch foraging indifference point 0 sec	0.3	0.4	0.6	-0.7	0.8	-0.5
Patch foraging indifference point AUC	2.4	2.8	3.3	1.8	-1.7	1.5
Delay disc. indifference point, 0s delay	3.7	4.1	5.3	-1.9	1.8	-2.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.3	-0.5	0.1
Delay disc. indifference point, 2s delay	0.3	0.4	0.5	-0.5	0.5	-0.7
Delay disc. indifference point, 24s delay	0.9	0.9	1.5	0.8	-1.2	0.7
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.1	-0.0	-0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.0	-0.3	-0.0
Indifference point function ln k	0.0	0.0	0.0	-0.1	0.2	-0.2
Indifference point function log k	0.0	0.0	0.0	-0.1	0.2	-0.2
Patch foraging total patch changes 0 sec	0.2	0.4	0.4	-0.6	0.7	-0.5
Patch foraging total patch changes 12 sec	0.7	0.9	1.0	-0.9	1.0	-0.9
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.1	0.1	-0.0
Patch foraging total patch changes 24 sec	0.7	0.8	1.0	-0.9	1.0	-0.9
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.2	0.2	0.1
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.2	0.0	0.1
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.1	-0.0	0.0
Patch foraging water rate 12 sec	1.7	2.5	2.7	-1.6	1.6	-1.6
Patch foraging water rate 18 sec	0.6	0.8	0.9	-0.9	0.9	-0.9
Patch foraging water rate 24 sec	2.2	3.0	3.7	-1.9	1.7	-1.6
Patch foraging water rate 6 sec	1.4	2.0	2.3	-1.3	1.4	-1.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.2	0.1	0.3
Distance traveled before self-admin	0.0	0.0	0.1	0.1	-0.1	-0.3
Distance traveled after self-admin	0.9	1.1	1.6	-0.9	0.9	-1.3
Extensor digitorum longus weight	4.4	17.4	18.2	4.2	-4.3	4.0
Bone: elastic displacement	0.8	0.9	1.3	0.8	-0.9	1.1
Bone: elastic work	1.1	1.4	1.5	1.1	-1.2	1.2
Bone: endosteal estimation	0.4	0.9	1.1	1.0	-1.0	0.9
Bone: endosteal perimeter	0.1	0.3	0.4	0.6	-0.6	0.5
Epididymis fat weight	14.2	33.1	36.7	-6.1	5.9	-5.3
Delta time in closed arm before/after self-admin	0.1	0.0	0.1	-0.2	0.2	-0.3
Delta time in open arm before/after self-admin	0.4	0.4	0.6	0.6	-0.6	0.8
Diff in mean of infusions in LGA sessions	0.2	0.2	0.3	0.3	-0.5	0.5
Delay discount exponential model param	0.1	0.1	0.2	-0.2	0.5	-0.1
Extinction: sum of active levers before priming	0.3	0.3	0.4	0.4	-0.7	0.5
Active lever presses in extinction session 6	0.7	0.7	1.6	0.4	-0.6	1.2
Bone: final force	0.1	0.2	0.3	0.5	-0.4	0.1
Bone: final moment	0.1	0.2	0.4	0.6	-0.5	0.2
Food consumed during 24 hour testing period	0.2	0.2	0.4	0.6	-0.5	0.0
Glucose	0.2	0.2	0.3	-0.5	0.6	-0.4
Heart weight	9.2	13.0	14.4	-3.3	3.7	-3.8
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.3	0.5	-0.2
Intermittent access intake day 1-15 change	0.1	0.1	0.2	0.5	-0.3	0.1
Intermittent access intake escalation	0.0	0.0	0.0	0.2	-0.1	-0.2
Intermittent access intake escalation 2	0.2	0.2	0.6	-0.1	0.4	-0.8
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.6	0.8	-0.3	0.4
Intermitt. access day 15 inactive lever presses	9.8	10.7	13.3	3.6	-3.0	3.1
Intermitt. access escalation Index	0.1	0.1	0.2	-0.0	0.3	-0.4
Intermittent access day 1 total infusions	5.6	6.5	7.0	2.5	-2.5	2.6
Intermittent access day 15 total infusions	2.5	2.8	3.0	1.7	-1.7	1.6
Intermittent access terminal intake (last 3 days)	2.1	2.3	2.4	1.6	-1.5	1.5
Intermittent access total infusions	2.3	2.5	3.0	1.5	-1.5	1.7
Intermittent access day 1 locomotion	2.2	2.4	2.4	1.5	-1.6	1.5
Intermittent access day 15 total locomotion	0.8	0.8	0.9	0.9	-0.9	0.9
Intermittent access total locomotion	0.3	0.4	0.6	0.5	-0.6	0.8
Intermittent access standard deviation	0.2	0.2	0.3	0.3	-0.4	0.5
Left kidney weight	0.0	0.1	0.1	-0.1	0.1	-0.4
Right kidney weight	1.3	3.7	4.5	-1.8	1.8	-2.1
Cocaine induced anxiety	0.4	0.5	0.6	0.8	-0.6	0.6
Post-drug Anxiety	0.9	1.0	1.6	-0.8	0.8	-1.3
Baseline Anxiety	1.7	1.8	2.2	-1.3	1.2	-1.5
Tail length	0.1	0.4	0.8	-0.9	0.5	-0.4
Length with tail	1.6	5.8	6.6	-2.6	2.3	-2.3
Length without tail	0.7	1.6	1.9	-1.2	1.2	-1.4
Times rat made contact with spout	1.7	1.9	2.4	1.5	-1.6	1.1
Lifetime Intake	3.3	3.7	4.6	1.8	-1.8	2.1
Liver weight, left	1.4	2.2	2.8	-1.3	1.4	-1.7
Liver weight, right	9.2	15.4	16.4	-3.8	3.9	-4.1
Locomotor activity	0.3	0.5	0.6	-0.7	0.6	-0.7
Locomotor testing distance	0.1	0.1	0.2	0.3	-0.4	0.4
Locomotor testing rearing	0.9	1.4	2.5	0.9	-1.0	1.6
Locomotion in novel chamber	0.9	1.1	1.8	-1.4	1.1	-0.6
Locomotion in novel chamber post-restriction	2.1	2.5	3.3	-1.8	1.6	-1.2
Fecal boli incidents, locomotor time 1	0.3	0.3	0.4	0.6	-0.5	0.6
Change in fecal boli incidents, locomotor task	4.5	4.3	4.6	-2.2	2.1	-2.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.4	0.2	-0.3
Bouts of movement, locomotor time 1	2.2	2.4	2.8	1.6	-1.7	1.3
Total resting periods, locomotor time 1	2.6	2.8	3.1	1.8	-1.8	1.5
Rest time, locomotor task time 1	0.1	0.1	0.3	0.2	-0.2	0.5
Distance moved, locomotor task time 1	1.3	1.4	1.5	-1.1	1.2	-1.2
Vertical activity count, locomotor time 1	0.7	0.7	1.0	-0.7	0.7	-1.0
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.3	-0.3	0.4
Bouts of movement, locomotor time 2	0.2	0.2	0.4	-0.3	0.3	-0.7
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.1	-0.0	-0.3
Rest time, locomotor task time 2	1.4	1.6	1.7	1.3	-1.3	1.2
Distance moved, locomotor task time 2	0.9	1.1	1.1	-1.1	1.1	-1.0
Vertical activity count, locomotor time 2	0.4	0.5	0.6	-0.7	0.7	-0.6
Light reinforcement 1	4.2	7.6	9.1	3.0	-2.8	2.4
Light reinforcement 2	3.7	5.0	6.3	2.5	-2.3	1.8
Bone: marrow area	0.5	1.0	1.1	1.1	-1.0	0.9
Bone: maximum diameter	0.8	1.5	1.9	1.4	-1.3	1.0
Bone: maximum force	0.0	0.0	0.1	0.3	-0.1	-0.0
Bone: maximum moment	0.0	0.1	0.1	0.4	-0.3	0.1
Mean time between licks in bursts	2.7	3.8	4.3	-1.9	1.9	-2.1
Mean num. licks in bursts	0.2	0.3	0.5	0.4	-0.4	0.7
Cd content in liver	0.0	0.0	0.0	0.1	-0.0	-0.0
Co content in liver	5.1	6.0	6.5	2.6	-2.5	2.2
Cu content in liver	0.0	0.0	0.1	0.1	-0.2	0.3
Fe content in liver	0.0	0.1	0.2	-0.1	0.1	0.4
K content in liver	0.2	0.2	0.4	-0.1	0.2	-0.7
Mg content in liver	0.2	0.3	0.5	-0.3	0.4	-0.7
Mn content in liver	0.6	0.7	0.8	0.8	-0.8	0.9
Na content in liver	0.5	0.5	0.7	0.8	-0.7	0.6
Rb content in liver	0.0	0.0	0.0	-0.1	0.1	-0.1
Se content in liver	0.2	0.3	0.4	-0.6	0.6	-0.4
Sr content in liver	0.2	0.2	0.5	-0.3	0.3	-0.7
Zn content in liver	1.5	1.6	1.8	-1.3	1.2	-1.3
Bone: minimum diameter	0.1	0.1	0.2	-0.3	0.4	-0.4
Time in familiar zone, hab. session 1	0.7	0.6	0.7	-0.7	0.8	-0.8
Time in novel zone, hab. session 1	0.5	0.5	0.9	-0.9	0.8	-0.3
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.4	-0.4	0.0
Total locomotion distance, hab. session 1	0.1	0.2	0.3	0.5	-0.5	0.3
Locomotion velocity, hab. session 1	0.9	1.3	1.7	1.3	-1.2	0.8
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.2	-0.1	-0.0
Time in novel zone, hab. session 2	0.5	0.5	0.8	-0.9	0.7	-0.5
Total zone transitions, hab. session 2	0.1	0.1	0.1	0.3	-0.4	-0.1
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.6	-0.5	0.1
Locomotion velocity, hab. session 2	0.3	0.5	0.6	0.8	-0.8	0.3
Novel to familiar place preference ratio	1.2	1.2	1.3	-1.1	1.0	-1.1
Novelty place preference	1.8	1.8	1.9	-1.4	1.3	-1.4
Time in novel zone, NPP test	2.0	2.0	2.3	-1.5	1.4	-1.3
Total zone transitions, NPP test	1.3	1.9	2.1	1.5	-1.4	1.2
Total locomotion distance, NPP test	1.9	2.7	2.9	1.7	-1.7	1.5
Locomotion velocity, NPP test	3.1	4.4	4.8	2.2	-2.2	1.8
Intraocular pressure	5.9	8.2	8.6	-2.9	2.8	-2.9
Delta distance traveled before/after self-admin	1.2	1.3	1.5	-1.0	1.2	-1.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.2	-0.3	0.5	-0.5
Parametrial fat weight	6.1	12.0	14.8	-3.1	3.4	-3.8
Pavlov. Cond. lever latency	1.7	2.2	2.7	-1.6	1.5	-1.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.2	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	-0.2	0.0
Pavlov. Cond. index score	0.7	0.8	1.2	1.1	-1.0	0.6
Pavlov. Cond. latency score	0.6	0.8	1.2	1.1	-1.0	0.6
Pavlov. Cond. lever contacts	1.0	1.1	1.5	1.2	-1.1	0.7
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	-0.9	0.8	-0.5
Pavlov. Cond. intertrial magazine entries	1.2	1.4	1.5	1.2	-1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	2.2	1.5	-1.4	1.1
Pavlov. Cond. response bias	1.4	1.7	2.1	1.4	-1.4	1.1
Pavlov. Cond. lever latency	1.6	2.2	2.5	-1.5	1.6	-1.3
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	0.7	-0.6	0.5
Pavlov. Cond. change in total contacts	0.5	0.7	0.9	0.9	-1.0	0.6
Pavlov. Cond. index score	1.1	1.4	1.6	1.3	-1.2	1.0
Pavlov. Cond. latency score	1.1	1.3	1.6	1.3	-1.2	1.0
Pavlov. Cond. lever contacts	0.7	1.0	1.2	1.0	-1.1	0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.5	0.4	-0.2
Pavlov. Cond. intertrial magazine entries	3.4	4.4	5.2	-2.3	2.1	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.2	1.1	-1.0	0.8
Pavlov. Cond. response bias	1.5	2.0	2.4	1.5	-1.5	1.2
Time in closed arm before self-admin	0.5	0.5	0.6	-0.8	0.7	-0.7
Time in closed arm after self-admin	1.4	1.4	1.9	-1.4	1.2	-0.9
Time in open arm before self-admin	0.1	0.1	0.2	0.1	-0.1	-0.4
Time in open arm after self-admin	1.9	2.0	2.5	1.6	-1.5	1.1
Bone: periosteal estimation	0.6	1.2	1.6	1.3	-1.1	0.8
Bone: periosteal perimeter	0.2	0.3	0.4	0.7	-0.6	0.2
Bone: post-yield work	0.4	0.6	0.6	0.8	-0.8	0.7
Progressive ratio test 1 active lever presses	1.8	1.8	2.8	1.1	-1.2	1.7
Progressive ratio test 1 breakpoint	1.5	1.6	2.5	1.1	-1.1	1.6
Progressive ratio test 1 inactive lever presses	4.8	5.3	7.0	2.2	-2.0	2.6
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	0.1	-0.2	0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	0.2	-0.3	0.7
Progressive ratio test 2 inactive lever presses	2.5	2.9	3.4	1.7	-1.5	1.8
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.3	0.2	-0.1
Incentive Sensitization - Breakpoint	0.2	0.2	0.2	-0.4	0.4	-0.3
Sum of active levers in priming session hrs 5-6	0.7	0.7	0.9	0.9	-1.0	0.6
Progressive ratio	0.1	0.1	0.4	0.1	-0.1	0.6
Food seeking constrained by brief footshock	4.7	5.8	8.3	2.1	-2.1	2.9
Seeking ratio, punishment vs. effort	0.4	0.5	0.6	0.7	-0.8	0.6
Retroperitoneal fat weight	21.2	69.5	72.1	-8.4	8.5	-8.1
Reaction time number correct	0.5	0.8	1.1	1.0	-0.9	0.7
Reaction time mean minus median	0.0	0.0	0.1	-0.1	0.1	0.2
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.2	0.3	-0.1
Reaction time num false alarms	0.0	0.1	0.1	0.3	-0.2	-0.0
Reaction time num false alarms AUC	0.1	0.1	0.1	0.4	-0.3	-0.1
Reaction time trials correct on left	0.5	0.8	1.1	1.0	-0.9	0.7
Reaction time trials on left	0.6	0.8	1.1	1.1	-0.9	0.7
Reaction time mean	1.2	1.6	1.7	-1.2	1.3	-1.3
Reaction time mean AUC	1.0	1.3	1.4	-1.1	1.2	-1.1
Median of all reaction times	1.3	1.8	2.2	-1.2	1.3	-1.5
Reaction time omissions	0.1	0.1	0.1	0.4	-0.3	0.3
Reaction time false alarm rate	0.1	0.1	0.2	-0.2	0.2	-0.5
Reaction time premature initiation rate	0.2	0.3	0.4	-0.6	0.5	-0.4
Reaction time premature initiations	0.0	0.0	0.0	-0.0	-0.0	-0.0
Std. dev. reaction times	0.3	0.4	0.5	-0.6	0.7	-0.6
Reaction time trials completed	0.6	0.8	1.1	1.1	-0.9	0.7
Reaction time trials AUC	0.8	1.1	1.4	1.2	-1.1	0.9
Run reversals in cocaine runway, females	0.2	0.2	0.2	-0.5	0.3	-0.4
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.3	-0.4	0.4
Latency to leave start box in cocaine runway	0.5	0.5	0.6	0.7	-0.8	0.7
Latency to leave start box in cocaine runway, F	0.5	0.5	0.7	0.7	-0.8	0.6
Latency to leave start box in cocaine runway, M	0.8	0.7	1.1	0.7	-0.7	1.1
Std. dev. time between licks in bursts	0.2	0.2	0.6	-0.2	0.3	-0.8
Total sessions with >9 infusions	2.8	3.1	4.7	1.5	-1.5	2.2
Short access day 1 total inactive lever presses	5.6	6.2	7.5	2.7	-2.4	2.3
Short access day 10 total inactive lever presses	1.3	1.4	1.9	1.4	-1.1	1.1
Short access day 1 total infusions	5.5	5.9	7.4	2.3	-2.2	2.7
Short access day 10 total infusions	4.3	4.8	5.5	2.1	-2.1	2.3
Short access total infusions	3.3	3.7	4.9	1.8	-1.7	2.2
Short access day 1 locomotion	7.0	7.6	9.6	2.5	-2.6	3.1
Short access day 10 total locomotion	0.8	0.9	1.0	1.0	-0.9	0.9
Short access total locomotion	0.7	0.7	1.0	0.8	-0.7	1.0
One hour access (0.3 mA shock)	1.8	2.1	2.3	1.5	-1.5	1.4
Compulsive drug intake	0.5	0.5	0.9	-0.5	0.6	-1.0
One hour access (shock baseline)	1.9	2.2	2.8	1.3	-1.4	1.7
Social response proportion	0.3	0.3	0.3	-0.6	0.6	-0.5
Social responses	0.1	0.1	0.2	-0.1	0.2	-0.4
Social time	0.3	0.4	0.5	-0.5	0.7	-0.6
Soleus weight	4.0	11.6	12.9	3.6	-3.6	3.0
Bone: stiffness	0.0	0.0	0.1	-0.1	0.1	-0.3
Tibialis anterior weight	3.5	11.8	12.6	3.5	-3.5	3.2
Time to tail flick, vehicle, before self-admin	2.5	2.6	3.2	-1.8	1.6	-1.3
Time to tail flick, vehicle, after self-admin	4.3	4.6	5.0	-2.2	2.2	-1.9
Time to tail flick, test, before self-admin	0.6	0.6	0.7	0.6	-0.7	0.9
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.0	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	0.6	-0.6	0.3
Tibia length	2.3	6.6	6.9	-2.5	2.6	-2.6
Ambulatory time before self-admin	0.1	0.1	0.1	0.3	-0.3	-0.0
Ambulatory time after self-admin	0.6	0.6	1.1	-0.6	0.7	-1.0
Bone: tissue strength	1.0	1.0	1.1	-1.0	0.9	-1.0
Total heroin consumption	2.5	2.9	3.4	1.7	-1.9	1.6
Bone: trabecular number	3.9	6.2	7.1	2.7	-2.6	2.2
Bone: trabecular spacing	3.4	4.4	5.3	-2.3	2.1	-1.9
Bone: trabecular thickness	0.8	0.9	1.1	1.1	-1.0	0.8
Bone: trabecular tissue density	0.2	0.2	0.3	0.6	-0.5	0.4
Water consumed over 24 hours	1.4	1.6	2.3	1.5	-1.4	0.8
Number of responses in last shaping day	0.5	0.5	0.8	0.6	-0.6	0.9