Hddc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	mRNA stability	Hddc3	0.07	0.04	8.1e-03	0.04	0.03	0.02	0.02	8.8e-03	1.6e-02	3.7e-02	3.6e-02
2	PL	mRNA stability	Hddc3	0.03	0.02	1.3e-03	0.02	0.02	0.02	0.01	4.8e-03	2.4e-03	1.9e-03	7.9e-03
3	RMTg	intron excision ratio	chr1_134299740_134299885	0.16	0.08	3.5e-04	0.14	0.15	0.12	0.12	1.8e-04	8.0e-05	4.2e-04	4.5e-04
4	RMTg	intron excision ratio	chr1_134299602_134299885	0.1	0.06	4.9e-03	0.04	0.04	0.04	0.03	4.0e-02	3.4e-02	3.0e-02	7.2e-02
5	PL	gene expression	Hddc3	0.04	0.02	4.4e-06	0.03	0.04	0.04	0.04	1.5e-04	1.1e-05	4.7e-05	2.8e-05
6	Brain	mRNA stability	Hddc3	0.13	0.07	6.7e-11	0.12	0.11	0.11	0.12	1.9e-11	1.8e-10	1.9e-10	8.8e-11
7	Brain	gene expression	Hddc3	0.08	0.04	1.2e-07	0.08	0.08	0.07	0.08	3.0e-08	6.4e-08	5.7e-07	7.5e-08
8	BLA	gene expression	Hddc3	0.05	0.03	3.2e-03	0.04	0.03	0.04	0.04	2.1e-03	1.0e-02	5.3e-03	4.2e-03
9	NAcc	gene expression	Hddc3	0.05	0.03	6.2e-07	0.07	0.06	0.06	0.06	5.4e-09	3.9e-07	4.3e-07	1.6e-07
10	Liver	gene expression	Hddc3	0.08	0.05	1.7e-05	0.02	0.02	0.02	0.03	1.6e-03	9.5e-04	1.5e-03	5.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10
Bone: apparent density	0.9	1.6	3.7	1.7	1.4	-1.9	-1.9	1.4	0.8	-0.8	-0.4	-0.6	-0.0
Area under the delay curve	0.9	0.9	1.5	-1.0	-0.5	1.1	1.2	-0.8	-1.0	1.0	1.0	0.7	-0.9
BMI with tail	1.0	3.3	7.4	-2.5	-2.7	2.1	2.3	-1.8	-1.3	1.3	1.0	1.3	0.1
BMI without tail	1.0	2.1	7.9	-2.4	-0.6	2.8	2.2	-1.2	-0.4	0.4	0.3	0.7	0.1
Body weight	0.4	1.7	2.6	-1.4	-1.6	0.7	1.4	-1.5	-1.3	1.3	1.3	1.3	-0.9
Weight adjusted by age	0.2	0.2	0.4	0.6	0.4	-0.7	-0.5	0.6	0.2	-0.2	-0.2	-0.2	-0.0
Bone surface	1.2	2.1	5.3	1.7	2.3	-1.4	-1.7	1.7	1.2	-1.2	-1.0	-1.0	0.2
Bone volume	1.1	1.9	4.4	1.6	2.1	-1.4	-1.8	1.6	1.1	-1.1	-0.8	-0.9	0.2
Breakpoint value in progressive ratio session	0.8	0.9	2.1	-0.9	-1.0	1.5	1.1	-1.1	-0.8	0.8	0.7	0.6	-0.2
Number of licking bursts	1.3	1.6	2.2	1.2	1.3	-0.9	-1.2	1.2	1.4	-1.4	-1.5	-1.3	1.0
Context. condit. distance diff. score	0.1	0.1	0.2	0.4	0.5	-0.2	-0.4	0.4	0.1	-0.1	-0.1	-0.1	-0.2
Locomotion velocity, session 1	0.1	0.1	0.3	-0.4	-0.6	0.3	0.4	-0.4	-0.0	0.0	0.2	0.1	0.0
Locomotion distance, session 1	0.0	0.0	0.1	0.0	-0.2	0.2	0.1	-0.2	-0.1	0.1	0.2	0.1	-0.2
Locomotion velocity, session 2	0.3	0.4	0.7	-0.8	-0.4	0.7	0.7	-0.8	-0.5	0.5	0.4	0.7	-0.5
Locomotion distance, session 2	0.0	0.0	0.1	0.1	0.2	-0.1	-0.2	0.1	0.1	-0.1	-0.3	-0.1	-0.1
Locomotion velocity, session 3	0.4	0.5	2.0	-0.6	1.4	1.1	0.4	0.2	0.5	-0.5	-0.8	-0.4	0.2
Locomotion distance, session 3	0.9	1.0	3.5	-0.4	1.9	1.0	0.3	0.4	1.1	-1.1	-1.3	-0.7	0.4
Stereotopy head waving bouts, day 3	1.2	1.4	4.9	1.8	0.6	-2.2	-1.8	1.0	-0.3	0.3	0.4	-0.0	-0.6
Stereotopy head waving duration, day 3	0.3	0.4	1.4	0.1	0.3	0.4	-0.1	0.7	0.6	-0.6	-0.5	-0.8	1.2
Locomotion velocity, session 7	0.8	0.9	2.9	-1.7	0.2	1.6	1.5	-1.0	-0.2	0.2	0.1	0.6	-0.5
Locomotion distance, session 7	0.3	0.3	1.0	-0.8	0.7	1.0	0.6	-0.0	0.4	-0.4	-0.6	-0.1	0.2
Stereotopy head waving bouts, day 7	0.8	0.9	1.7	1.1	1.3	-1.1	-1.1	1.3	0.7	-0.7	-0.4	-0.6	0.2
Stereotopy head waving duration, day 7	0.1	0.2	0.7	-0.1	0.8	0.3	0.1	0.5	0.5	-0.5	-0.2	-0.3	0.3
Locomotion velocity, session 8	1.5	1.7	4.8	-2.0	-1.2	2.2	1.7	-1.4	-0.8	0.8	0.7	0.8	-0.2
Locomotion distance, session 8	0.1	0.1	0.7	0.1	0.4	-0.0	-0.2	0.0	-0.3	0.3	0.2	0.3	-0.8
Degree of sensitization distance	0.1	0.1	0.4	-0.3	-0.7	0.2	0.2	-0.2	-0.2	0.2	0.3	0.2	0.3
Degree of sensitization stereotypy	0.0	0.0	0.2	-0.2	0.4	-0.1	0.1	0.2	-0.0	0.0	0.2	0.2	-0.3
Conditioned locomotion	0.3	0.4	1.0	0.6	-0.2	-1.0	-0.5	-0.2	-0.5	0.5	0.7	0.6	-0.9
Cocaine response after cond. corrected	0.2	0.2	0.8	0.3	-0.9	-0.7	-0.2	-0.4	-0.3	0.3	0.3	0.3	-0.1
Cocaine response after cond. not corrected	0.2	0.3	1.0	-0.1	-1.0	-0.0	0.3	-0.6	-0.5	0.5	0.6	0.4	-0.2
Cocaine response before conditioning	0.1	0.1	0.2	0.1	0.4	0.4	0.1	0.0	-0.3	0.3	0.5	-0.0	-0.3
Saline control response	1.2	1.6	4.3	-1.5	0.5	2.1	2.1	-1.1	-0.8	0.8	0.8	0.7	-1.3
Bone: connectivity density	1.5	2.3	5.4	2.2	1.4	-2.3	-2.2	1.6	1.1	-1.1	-0.6	-0.8	0.2
Bone: cortical apparent density	2.0	2.7	4.9	-1.6	-2.2	0.8	1.4	-1.9	-1.6	1.6	1.8	1.7	-1.2
Bone: cortical area	0.6	0.9	3.0	1.1	1.7	-1.2	-1.1	0.5	-0.0	0.0	0.2	0.2	-1.4
Bone: cortical porosity	0.5	0.5	1.3	0.3	0.4	-0.2	-0.3	0.9	0.8	-0.8	-0.8	-0.8	1.1
Bone: cortical porosity	0.4	0.4	1.0	0.2	0.5	-0.1	-0.2	0.9	0.7	-0.7	-0.7	-0.8	1.0
Bone: cortical thickness	0.2	0.4	1.3	0.6	0.6	-0.9	-0.7	-0.1	-0.3	0.3	0.6	0.5	-1.2
Bone: cortical thickness	1.1	1.3	5.6	1.7	-0.1	-2.4	-1.8	0.6	0.5	-0.5	-0.4	-0.3	0.1
Bone: cortical tissue density	1.8	2.4	4.8	-1.4	-2.2	0.7	1.2	-1.8	-1.6	1.6	1.7	1.6	-1.1
Condit. Reinf. active minus inactive responses	1.4	1.6	4.1	-0.6	-0.9	0.0	0.8	-1.1	-1.5	1.5	1.6	1.4	-2.0
Condit. Reinf. active-inactive response ratio	0.5	0.5	2.1	0.7	1.5	-0.6	-0.6	0.8	0.5	-0.5	-0.5	-0.7	-0.4
Condit. Reinf. active responses	1.7	2.1	4.2	-0.7	-1.3	0.0	1.0	-1.2	-1.7	1.7	1.9	1.6	-2.1
Condit. Reinf. inactive responses	1.1	1.3	2.2	-0.8	-1.5	0.5	1.1	-1.1	-1.2	1.2	1.4	1.3	-0.9
Incentive salience index mean	4.2	5.0	9.1	-1.8	-1.7	1.0	1.9	-2.2	-2.5	2.5	2.6	2.5	-3.0
Condit. Reinf. lever presses	7.5	10.0	12.0	-3.2	-2.7	2.4	3.2	-3.5	-3.2	3.2	3.4	3.4	-3.4
Condit. Reinf. active minus inactive responses	1.3	1.6	2.6	-0.8	-1.5	0.5	0.9	-1.1	-1.6	1.6	1.6	1.3	-1.2
Condit. Reinf. active-inactive response ratio	0.8	0.8	2.6	-0.2	-1.6	-0.2	0.3	-0.6	-1.1	1.1	1.2	0.9	-0.6
Condit. Reinf. active responses	1.4	2.0	2.8	-1.2	-1.0	1.1	1.3	-1.4	-1.7	1.7	1.6	1.3	-1.5
Condit. Reinf. inactive responses	1.2	1.4	3.4	-1.4	0.6	1.8	1.4	-1.2	-1.0	1.0	0.8	0.9	-1.4
Condit. Reinf. lever presses	1.1	1.5	7.3	-1.7	0.2	2.7	2.0	-0.8	-0.2	0.2	0.1	-0.1	0.2
Condit. Reinf. lever reinforcers received	1.8	2.5	3.5	-1.4	-1.0	1.3	1.5	-1.6	-1.9	1.9	1.8	1.6	-1.7
Conditioned reinforcement - actives	0.0	0.0	0.2	0.1	-0.0	-0.5	-0.2	0.3	0.1	-0.1	-0.3	0.2	-0.0
Conditioned reinforcement - inactives	1.3	1.5	3.8	1.5	1.2	-2.0	-1.6	0.9	0.9	-0.9	-1.1	-1.0	0.2
Conditioned locomotion	0.3	0.4	1.5	0.6	-0.1	-0.6	-0.6	0.5	0.5	-0.5	-0.6	-0.5	1.2
Patch foraging indifference point 0 sec	0.1	0.1	0.5	0.0	0.7	0.7	0.1	-0.0	0.0	-0.0	0.1	-0.3	-0.0
Patch foraging indifference point AUC	1.2	1.4	2.6	1.6	1.4	-1.2	-1.4	1.6	0.8	-0.8	-0.7	-1.0	0.3
Delay disc. indifference point, 0s delay	0.3	0.4	0.9	0.6	-0.5	-0.9	-0.3	-0.0	-0.6	0.6	0.7	0.5	-0.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.3	0.5	0.5	0.4	0.2	0.1	-0.1	0.1	-0.3	0.1
Delay disc. indifference point, 2s delay	0.4	0.5	2.1	-1.0	0.3	1.5	1.0	-0.3	-0.3	0.3	0.3	0.0	-0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.1	0.3	-0.2	-0.2	0.2	0.0	-0.0	-0.1	-0.1	-0.0
Delay disc. indifference point, 4s delay	2.0	2.1	3.5	-1.7	-0.4	1.9	1.8	-1.5	-1.3	1.3	1.1	1.3	-1.6
Delay disc. indifference point, 8s delay	0.9	0.9	1.3	-1.0	-1.0	1.0	1.1	-0.8	-1.1	1.1	0.9	0.8	-0.7
Indifference point function ln k	0.4	0.5	1.3	-0.8	-0.3	1.2	0.7	-0.5	0.5	-0.5	-0.5	-0.4	1.2
Indifference point function log k	0.4	0.5	1.3	-0.8	-0.3	1.2	0.7	-0.5	0.5	-0.5	-0.5	-0.4	1.2
Patch foraging total patch changes 0 sec	0.2	0.3	1.2	0.3	1.1	0.6	-0.1	0.4	0.5	-0.5	-0.4	-0.8	0.4
Patch foraging total patch changes 12 sec	2.6	3.4	7.8	2.8	2.1	-2.6	-2.6	1.9	1.1	-1.1	-0.9	-1.3	-0.1
Patch foraging total patch changes 18 sec	1.9	2.5	5.3	2.3	2.1	-1.7	-1.9	1.6	1.2	-1.2	-1.0	-1.4	0.3
Patch foraging total patch changes 24 sec	0.3	0.4	1.8	0.8	1.4	0.0	-0.6	0.5	0.3	-0.3	-0.3	-0.5	-0.2
Patch foraging total patch changes 6 sec	0.3	0.4	1.7	0.1	0.7	0.3	0.0	0.0	-0.7	0.7	0.8	0.5	-1.3
Patch foraging time to switch 0 sec	0.4	0.6	1.5	1.2	1.1	-1.0	-1.0	0.6	0.5	-0.5	-0.4	-0.5	-0.3
Patch foraging water rate 0 sec	0.5	0.8	1.7	-1.3	-1.3	1.2	1.1	-0.6	-0.5	0.5	0.5	0.6	0.4
Patch foraging water rate 12 sec	6.5	9.9	18.0	-4.2	-3.5	3.9	4.1	-3.2	-2.5	2.5	2.5	2.5	-1.2
Patch foraging water rate 18 sec	2.9	4.0	10.5	-3.2	-1.8	3.1	2.9	-1.7	-1.0	1.0	1.0	1.4	-0.0
Patch foraging water rate 24 sec	0.9	1.3	3.6	-1.5	-1.9	1.1	1.3	-1.3	-0.7	0.7	0.7	1.0	0.1
Patch foraging water rate 6 sec	2.6	3.8	7.1	-2.7	-2.4	2.2	2.6	-2.1	-1.4	1.4	1.4	1.7	-0.4
Seeking ratio, delayed vs. immediate footshock	2.5	2.9	7.3	-0.0	-1.3	-2.2	-0.3	-0.9	-1.8	1.8	1.6	2.3	-2.7
Distance traveled before self-admin	1.3	1.4	3.0	-0.1	-0.8	0.2	0.4	-1.5	-1.4	1.4	1.3	1.3	-1.7
Distance traveled after self-admin	0.5	0.6	3.0	0.4	1.2	-0.5	-0.4	-0.1	-0.1	0.1	-0.0	0.7	-1.7
Extensor digitorum longus weight	0.3	1.2	2.6	-1.6	-0.7	1.6	1.6	-1.2	-0.7	0.7	0.7	0.8	-0.5
Bone: elastic displacement	1.6	1.8	5.0	-0.2	-2.2	-1.3	0.1	-1.0	-1.4	1.4	1.3	1.7	-1.2
Bone: elastic work	0.5	0.7	1.6	-0.3	-0.9	-0.7	0.1	-0.7	-0.9	0.9	0.8	1.1	-1.3
Bone: endosteal estimation	3.0	6.5	11.6	2.9	3.4	-2.2	-2.7	3.1	2.3	-2.3	-2.5	-2.3	1.4
Bone: endosteal perimeter	1.3	2.8	5.3	2.1	2.3	-2.0	-1.9	2.1	1.2	-1.2	-1.3	-1.2	0.3
Epididymis fat weight	2.0	4.7	9.9	-1.4	-3.1	0.2	1.6	-2.1	-2.6	2.6	2.4	2.2	-1.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.2	-0.8	-0.6	-0.1	0.5	-0.5	0.5	0.4	0.2	-0.0
Delta time in open arm before/after self-admin	1.0	1.0	2.3	-1.3	-0.6	1.5	1.1	-1.3	-0.7	0.7	0.6	0.7	-0.5
Diff in mean of infusions in LGA sessions	0.4	0.5	2.4	0.2	1.5	0.1	-0.2	0.6	0.7	-0.7	-0.8	-0.4	-0.4
Delay discount exponential model param	1.1	1.1	1.8	1.2	0.4	-1.3	-1.3	0.9	1.1	-1.1	-1.1	-0.8	1.0
Extinction: sum of active levers before priming	1.2	1.2	2.2	-0.8	-1.5	0.3	0.8	-1.0	-1.3	1.3	1.2	1.3	-0.9
Active lever presses in extinction session 6	1.2	1.1	2.9	-0.6	-1.7	0.2	0.7	-1.1	-1.2	1.2	1.1	1.4	-0.4
Bone: final force	0.3	0.5	1.7	1.0	1.3	-0.9	-1.0	0.6	0.1	-0.1	-0.0	-0.2	-0.7
Bone: final moment	0.3	0.5	1.4	0.9	1.2	-0.9	-0.9	0.6	0.1	-0.1	-0.0	-0.1	-0.7
Food consumed during 24 hour testing period	0.9	1.0	2.2	1.5	1.3	-0.6	-1.1	1.2	0.8	-0.8	-0.7	-1.1	0.7
Glucose	0.2	0.2	0.7	0.6	-0.8	-0.5	-0.5	0.3	0.0	-0.0	-0.3	-0.4	0.6
Heart weight	0.3	0.4	1.8	0.0	-1.4	-0.2	0.3	-0.4	-0.8	0.8	0.6	0.7	-0.2
Delay discount hyperbolic model param	1.1	1.1	2.2	1.2	0.3	-1.5	-1.4	0.9	1.1	-1.1	-1.0	-0.7	1.0
Intermittent access intake day 1-15 change	0.1	0.1	0.4	0.3	0.5	-0.2	-0.2	0.0	-0.1	0.1	-0.0	0.0	-0.7
Intermittent access intake escalation	0.1	0.1	0.5	0.2	0.4	-0.5	-0.3	0.2	-0.0	0.0	-0.0	0.1	-0.7
Intermittent access intake escalation 2	0.5	0.5	1.1	0.9	1.0	-1.0	-0.9	0.5	0.5	-0.5	-0.7	-0.4	-0.4
Intermitt. access day 1 inactive lever presses	2.8	3.0	4.7	-0.9	-2.0	-0.0	1.1	-1.9	-2.1	2.1	2.2	1.6	-2.0
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.7	0.1	-0.1	-0.8	-0.2	-0.4	-0.4	0.4	0.4	0.4	-0.8
Intermitt. access escalation Index	0.2	0.1	0.3	-0.4	-0.1	0.5	0.4	-0.4	-0.3	0.3	0.3	0.3	-0.5
Intermittent access day 1 total infusions	0.1	0.1	0.5	0.5	0.2	-0.7	-0.4	0.0	0.3	-0.3	-0.4	0.1	0.2
Intermittent access day 15 total infusions	0.1	0.1	0.3	0.2	0.0	-0.6	-0.2	-0.3	-0.0	0.0	-0.1	0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.4	0.3	0.6	-0.6	-0.4	0.1	0.4	-0.4	-0.6	0.1	-0.2
Intermittent access total infusions	0.1	0.1	0.6	0.3	-0.0	-0.8	-0.3	-0.1	0.1	-0.1	-0.3	0.3	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.0	0.0	-0.5	-0.2	-0.4	0.1	-0.1	-0.2	0.3	-0.1
Intermittent access day 15 total locomotion	0.4	0.4	1.2	-0.8	-0.3	0.0	0.5	-0.8	-0.4	0.4	0.3	0.9	-1.1
Intermittent access total locomotion	0.3	0.4	0.6	0.4	0.7	-0.8	-0.7	0.3	0.7	-0.7	-0.8	-0.4	0.1
Intermittent access standard deviation	2.5	2.7	5.0	2.2	1.9	-1.9	-2.0	1.4	1.4	-1.4	-1.4	-1.6	0.6
Left kidney weight	0.2	0.6	1.2	0.4	-1.0	-1.1	-0.3	0.1	-0.8	0.8	0.8	0.8	-0.7
Right kidney weight	0.1	0.3	0.7	-0.1	-0.8	-0.1	0.4	-0.2	-0.7	0.7	0.7	0.5	-0.4
Cocaine induced anxiety	0.1	0.1	0.2	0.3	0.4	-0.1	-0.1	0.4	0.1	-0.1	-0.3	-0.5	-0.3
Post-drug Anxiety	0.6	0.6	2.8	-0.5	-0.3	0.1	0.5	-0.8	-0.9	0.9	0.7	0.7	-1.7
Baseline Anxiety	3.0	3.2	5.5	-2.0	-1.6	1.1	1.6	-2.3	-1.7	1.7	1.7	2.1	-1.8
Tail length	0.2	0.5	3.3	-0.0	1.8	0.1	-0.0	0.2	0.3	-0.3	-0.0	0.1	-1.1
Length with tail	0.2	0.7	3.5	0.3	0.6	-0.9	-0.2	-0.4	-0.6	0.6	1.0	0.8	-1.9
Length without tail	0.3	0.7	1.5	0.4	-1.0	-1.2	-0.3	-0.5	-0.9	0.9	1.0	0.7	-0.8
Times rat made contact with spout	0.7	0.8	2.3	-0.7	-1.5	0.3	0.9	-0.9	-1.0	1.0	1.0	1.0	-0.5
Lifetime Intake	0.1	0.1	0.3	0.1	-0.2	-0.5	-0.1	-0.3	-0.1	0.1	-0.0	0.4	-0.2
Liver weight, left	0.8	1.3	3.9	-0.3	-2.0	-0.3	0.2	-0.8	-1.5	1.5	1.3	1.3	-0.8
Liver weight, right	1.4	2.3	4.2	0.1	-1.5	-0.9	-0.2	-1.2	-2.0	2.0	1.8	1.8	-2.0
Locomotor activity	0.6	1.0	2.8	-0.9	0.5	1.7	0.8	0.7	0.8	-0.8	-0.9	-0.9	1.6
Locomotor testing distance	0.7	1.2	4.5	-1.5	-0.9	2.1	1.7	-0.7	-0.5	0.5	0.4	0.4	0.7
Locomotor testing rearing	0.4	0.6	2.4	-1.1	0.1	1.6	1.2	-0.7	-0.4	0.4	0.4	0.4	-0.1
Locomotion in novel chamber	0.2	0.3	1.0	-0.2	0.0	0.5	0.3	-0.5	-0.6	0.6	0.5	0.3	-1.0
Locomotion in novel chamber post-restriction	0.2	0.2	0.4	0.1	0.5	0.4	-0.2	0.4	0.5	-0.5	-0.7	-0.6	0.6
Fecal boli incidents, locomotor time 1	0.9	1.0	5.4	1.5	-0.2	-2.3	-1.4	0.5	-0.1	0.1	0.2	-0.0	-0.3
Change in fecal boli incidents, locomotor task	0.3	0.3	1.0	-0.7	0.4	1.0	0.3	0.0	0.5	-0.5	-0.4	-0.3	0.4
Time >=10cm from walls, locomotor time 1	3.6	3.6	5.6	-2.4	-1.4	2.0	2.0	-2.2	-1.8	1.8	1.6	2.0	-1.6
Bouts of movement, locomotor time 1	0.4	0.5	1.2	-0.8	-0.2	0.2	0.6	-0.4	-0.8	0.8	0.8	0.7	-1.1
Total resting periods, locomotor time 1	0.6	0.7	1.8	-0.8	-0.2	0.2	0.6	-0.4	-0.9	0.9	1.1	1.0	-1.4
Rest time, locomotor task time 1	0.5	0.5	1.5	0.7	0.9	-1.2	-0.8	0.5	-0.2	0.2	0.1	0.4	-1.2
Distance moved, locomotor task time 1	0.4	0.4	1.4	-0.7	-0.8	1.2	0.9	-0.7	-0.1	0.1	0.2	0.1	0.5
Vertical activity count, locomotor time 1	0.5	0.5	1.3	-0.1	0.4	0.9	0.1	0.1	0.9	-0.9	-0.9	-0.8	1.1
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.1	-1.0	0.3	0.7	0.6	-0.3	-0.2	0.2	0.1	0.7	-1.0
Bouts of movement, locomotor time 2	2.6	2.8	5.8	1.3	2.4	-1.6	-2.0	2.2	1.4	-1.4	-1.6	-1.4	0.5
Total resting periods, locomotor time 2	3.6	3.9	6.7	1.8	2.6	-2.1	-2.5	2.5	1.7	-1.7	-1.9	-1.6	0.7
Rest time, locomotor task time 2	1.4	1.6	7.1	1.9	0.4	-2.7	-2.0	0.9	0.1	-0.1	-0.2	-0.2	-0.5
Distance moved, locomotor task time 2	0.1	0.1	0.4	-0.1	0.4	0.6	0.4	0.0	0.3	-0.3	-0.3	-0.1	0.1
Vertical activity count, locomotor time 2	0.2	0.2	0.4	0.1	0.5	0.6	0.1	0.2	0.6	-0.6	-0.6	-0.5	0.6
Light reinforcement 1	4.3	7.8	13.1	3.6	3.2	-3.3	-3.6	2.6	2.5	-2.5	-2.4	-2.4	1.0
Light reinforcement 2	1.3	1.8	5.2	1.9	1.3	-2.3	-2.0	1.2	0.5	-0.5	-0.5	-0.6	-0.6
Bone: marrow area	3.2	6.8	12.0	2.9	3.5	-2.2	-2.8	3.1	2.4	-2.4	-2.5	-2.4	1.4
Bone: maximum diameter	1.2	2.2	8.4	1.5	2.9	-1.2	-1.6	1.8	1.1	-1.1	-1.1	-0.9	-0.3
Bone: maximum force	0.3	0.5	2.1	0.9	1.4	-0.8	-0.9	0.7	0.2	-0.2	-0.2	-0.1	-0.7
Bone: maximum moment	0.3	0.4	1.6	0.8	1.3	-0.8	-0.8	0.6	0.2	-0.2	-0.1	-0.0	-0.7
Mean time between licks in bursts	1.1	1.6	6.7	1.9	0.5	-2.6	-2.0	1.2	0.2	-0.2	-0.3	-0.2	-0.5
Mean num. licks in bursts	2.9	3.4	6.6	-1.6	-2.6	0.9	1.6	-1.8	-2.1	2.1	2.1	1.9	-1.3
Cd content in liver	1.8	2.0	6.5	2.3	-0.1	-2.6	-1.9	1.2	0.8	-0.8	-0.7	-0.8	0.8
Co content in liver	0.1	0.1	0.5	0.3	-0.7	-0.6	-0.2	-0.1	-0.0	0.0	0.1	0.1	-0.0
Cu content in liver	1.4	1.7	2.5	-1.4	-0.7	1.2	1.6	-1.2	-1.3	1.3	1.3	1.3	-1.4
Fe content in liver	0.1	0.1	0.6	0.3	0.8	-0.2	-0.3	0.4	0.3	-0.3	-0.4	-0.2	-0.1
K content in liver	0.7	0.7	3.1	-0.3	1.8	1.0	0.2	0.5	0.7	-0.7	-0.8	-0.6	0.3
Mg content in liver	1.4	1.4	3.3	0.0	1.8	1.0	-0.0	0.9	1.4	-1.4	-1.4	-1.3	1.3
Mn content in liver	0.4	0.5	0.9	-0.4	-0.7	-0.1	0.1	-0.7	-0.8	0.8	0.8	0.9	-1.0
Na content in liver	1.2	1.2	5.5	-0.3	2.3	1.2	0.2	0.8	1.1	-1.1	-1.1	-0.8	0.4
Rb content in liver	0.3	0.4	1.0	-0.2	0.1	0.8	0.3	0.2	0.6	-0.6	-0.8	-0.8	1.0
Se content in liver	0.1	0.1	0.4	0.4	0.1	-0.6	-0.5	0.3	-0.1	0.1	0.0	0.0	-0.3
Sr content in liver	0.3	0.3	1.3	-0.6	0.3	1.2	0.7	0.0	0.3	-0.3	-0.1	-0.3	0.5
Zn content in liver	0.8	0.8	2.1	1.0	1.5	-0.3	-0.6	1.2	0.8	-0.8	-0.7	-1.0	0.6
Bone: minimum diameter	2.9	5.5	10.3	3.2	2.9	-3.1	-3.1	2.7	1.6	-1.6	-1.6	-1.5	0.3
Time in familiar zone, hab. session 1	0.2	0.1	0.5	-0.0	0.1	0.6	0.3	-0.0	0.3	-0.3	-0.4	-0.5	0.7
Time in novel zone, hab. session 1	0.1	0.1	0.6	0.2	-0.2	-0.8	-0.2	-0.0	0.0	-0.0	0.0	0.2	-0.5
Total zone transitions, hab. session 1	1.0	1.4	4.2	-1.7	-0.0	2.0	1.7	-1.3	-0.7	0.7	0.5	0.9	-0.8
Total locomotion distance, hab. session 1	1.7	2.4	7.0	1.8	-0.2	-2.6	-1.5	-0.1	-1.3	1.3	1.4	1.2	-2.3
Locomotion velocity, hab. session 1	2.0	2.8	7.3	1.4	-0.4	-2.4	-1.3	-0.4	-1.7	1.7	1.7	1.6	-2.7
Time in familiar zone, hab. session 2	2.1	2.1	2.8	1.6	1.2	-1.5	-1.7	1.5	1.5	-1.5	-1.6	-1.3	1.2
Time in novel zone, hab. session 2	0.7	0.7	1.3	-1.0	-0.7	0.9	1.1	-0.9	-0.7	0.7	0.9	0.6	-0.8
Total zone transitions, hab. session 2	0.7	0.9	4.0	-1.4	0.3	2.0	1.5	-0.7	-0.2	0.2	0.2	0.3	-0.3
Total locomotion distance, hab. session 2	1.6	2.1	7.2	2.2	0.5	-2.7	-1.8	0.6	-0.7	0.7	0.8	0.6	-1.7
Locomotion velocity, hab. session 2	1.4	1.9	5.8	1.8	0.2	-2.4	-1.5	0.2	-1.0	1.0	1.1	0.9	-1.9
Novel to familiar place preference ratio	0.7	0.7	1.5	0.3	1.2	0.2	-0.4	0.8	1.0	-1.0	-0.9	-0.9	0.8
Novelty place preference	0.5	0.5	1.1	0.1	1.0	0.3	-0.3	0.7	0.9	-0.9	-0.8	-0.7	0.7
Time in novel zone, NPP test	0.4	0.4	0.7	-0.1	0.8	0.6	0.0	0.5	0.8	-0.8	-0.7	-0.7	0.8
Total zone transitions, NPP test	0.4	0.5	0.9	-0.8	-0.5	0.8	0.8	-1.0	-0.6	0.6	0.6	0.7	-0.5
Total locomotion distance, NPP test	2.8	3.8	15.3	2.9	-0.4	-3.9	-2.5	0.4	-1.0	1.0	1.2	1.0	-1.8
Locomotion velocity, NPP test	2.9	4.0	16.1	3.0	-0.2	-4.0	-2.7	0.5	-1.0	1.0	1.2	1.0	-1.8
Intraocular pressure	0.0	0.0	0.1	-0.2	-0.1	0.2	0.1	0.1	0.0	-0.0	-0.0	0.1	0.4
Delta distance traveled before/after self-admin	3.0	3.3	6.9	1.2	2.6	-0.8	-1.4	2.2	2.1	-2.1	-2.1	-1.6	1.0
Delta ambulatory time before/after self-admin	1.9	2.1	3.8	1.0	2.0	-1.0	-1.2	1.8	1.6	-1.6	-1.6	-1.1	0.7
Parametrial fat weight	3.7	7.3	9.9	-3.0	-3.2	1.9	2.6	-3.1	-2.7	2.7	2.6	2.9	-2.1
Pavlov. Cond. lever latency	6.5	8.3	13.1	2.8	1.7	-1.9	-2.4	2.8	3.1	-3.1	-3.2	-3.5	3.6
Pavlov. Cond. magazine entry latency	4.9	6.3	13.8	-1.7	-1.7	0.4	1.5	-2.5	-2.9	2.9	2.8	3.2	-3.7
Pavlov. Cond. change in total contacts	6.0	6.4	16.3	-0.9	-1.5	-0.6	0.7	-2.1	-3.1	3.1	3.0	3.4	-4.0
Pavlov. Cond. index score	7.0	8.9	16.0	-2.5	-2.0	1.3	2.2	-2.9	-3.4	3.4	3.3	3.7	-4.0
Pavlov. Cond. latency score	7.1	9.0	15.8	-2.6	-1.9	1.5	2.3	-3.0	-3.3	3.3	3.3	3.7	-4.0
Pavlov. Cond. lever contacts	5.8	6.8	12.1	-2.5	-1.4	1.6	2.0	-2.5	-2.8	2.8	2.8	3.3	-3.5
Pavlov. Cond. magazine entry number	5.2	6.4	10.6	2.1	2.0	-1.1	-2.0	2.7	2.9	-2.9	-2.7	-3.0	3.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.2	-0.1	0.5	0.4	-0.1	-0.4	0.4	0.3	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	7.4	9.2	16.4	-2.4	-2.2	1.1	2.1	-3.0	-3.5	3.5	3.4	3.8	-4.0
Pavlov. Cond. response bias	3.9	4.7	10.2	-1.3	-1.5	0.1	1.0	-2.0	-2.6	2.6	2.5	2.9	-3.2
Pavlov. Cond. lever latency	3.1	4.2	7.3	2.5	0.9	-2.7	-2.6	2.2	1.9	-1.9	-1.7	-1.5	1.7
Pavlov. Cond. magazine entry latency	4.2	4.9	6.4	-2.3	-2.1	2.2	2.5	-2.4	-2.3	2.3	2.2	1.9	-1.6
Pavlov. Cond. change in total contacts	4.7	6.4	8.5	-2.8	-1.4	2.7	2.9	-2.7	-2.6	2.6	2.5	2.3	-2.5
Pavlov. Cond. index score	5.3	6.8	10.6	-3.0	-1.6	3.1	3.3	-2.8	-2.6	2.6	2.4	2.2	-2.2
Pavlov. Cond. latency score	4.6	5.7	8.9	-2.8	-1.4	2.9	3.0	-2.5	-2.4	2.4	2.2	1.9	-2.0
Pavlov. Cond. lever contacts	3.4	4.6	10.2	-2.9	-0.6	3.2	3.0	-2.2	-1.7	1.7	1.5	1.5	-1.7
Pavlov. Cond. magazine entry number	3.4	4.2	6.7	2.3	1.7	-2.6	-2.6	2.1	2.0	-2.0	-1.9	-1.5	1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.2	1.1	-0.2	1.1	0.0	-0.2	0.4	0.5	-0.5	-0.6	-0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	4.9	6.3	10.0	-3.0	-1.5	3.1	3.2	-2.7	-2.4	2.4	2.2	2.1	-2.1
Pavlov. Cond. response bias	4.2	5.8	10.3	-3.0	-1.2	3.2	3.1	-2.6	-2.1	2.1	1.9	1.9	-2.0
Time in closed arm before self-admin	0.4	0.4	1.7	0.5	1.3	-0.5	-0.6	-0.1	0.5	-0.5	-0.7	0.0	-0.8
Time in closed arm after self-admin	0.4	0.4	1.7	1.0	0.4	-1.3	-0.9	0.5	0.0	-0.0	-0.1	-0.2	-0.6
Time in open arm before self-admin	0.3	0.3	1.3	0.3	-1.2	-0.6	0.1	0.2	-0.5	0.5	0.7	-0.0	0.4
Time in open arm after self-admin	2.7	2.9	4.0	-1.9	-2.0	2.0	2.0	-1.8	-1.6	1.6	1.7	1.4	-0.6
Bone: periosteal estimation	1.9	4.0	10.4	2.5	3.2	-2.1	-2.4	2.3	1.5	-1.5	-1.5	-1.4	0.1
Bone: periosteal perimeter	0.8	1.4	3.8	1.5	1.9	-1.6	-1.5	1.3	0.6	-0.6	-0.6	-0.5	-0.5
Bone: post-yield work	0.8	1.1	3.9	0.7	2.0	0.1	-0.6	1.1	1.0	-1.0	-1.1	-1.0	0.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.3	0.2	-0.5	-0.4	0.3	0.3	-0.3	-0.4	-0.2	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.3	0.3	-0.4	-0.4	0.2	0.3	-0.3	-0.4	-0.2	0.1
Progressive ratio test 1 inactive lever presses	1.9	2.1	3.6	-1.0	-1.7	-0.0	1.2	-1.9	-1.5	1.5	1.5	1.6	-1.7
Progressive ratio test 2 active lever presses	0.5	0.5	1.0	0.3	1.0	-0.9	-0.7	0.5	0.8	-0.8	-1.0	-0.1	-0.2
Progressive ratio test 2 breakpoint	0.6	0.6	1.3	0.5	1.2	-1.0	-0.8	0.5	0.9	-0.9	-1.1	-0.3	-0.1
Progressive ratio test 2 inactive lever presses	0.3	0.4	1.4	-0.5	-0.1	-0.3	0.3	-0.8	-0.4	0.4	0.4	0.8	-1.2
Incentive Sensitization - Responses	0.5	0.6	1.7	-0.1	1.3	-0.4	-0.4	0.4	1.0	-1.0	-1.2	-0.1	-0.3
Incentive Sensitization - Breakpoint	0.5	0.5	1.6	-0.0	1.3	-0.5	-0.4	0.4	0.9	-0.9	-1.1	-0.2	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.4	-0.1	-0.6	-0.6	0.3	0.4	-0.4	-0.4	0.0	0.6
Progressive ratio	0.1	0.1	0.6	-0.4	0.3	-0.2	0.1	0.0	-0.1	0.1	-0.1	0.5	-0.7
Food seeking constrained by brief footshock	0.6	0.8	1.4	-0.9	-0.0	0.9	0.9	-1.0	-0.7	0.7	0.6	1.1	-1.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.0	-0.4	0.4	0.2	-0.6	-0.4	0.4	0.5	0.1	-0.1
Retroperitoneal fat weight	6.0	19.8	33.9	-3.9	-5.8	2.5	4.1	-4.7	-4.9	4.9	4.9	4.5	-3.3
Reaction time number correct	0.5	0.8	1.7	0.6	0.2	-0.5	-0.7	0.9	1.1	-1.1	-0.9	-0.9	1.3
Reaction time mean minus median	0.1	0.2	0.8	-0.3	0.6	0.9	0.4	-0.3	-0.1	0.1	-0.1	0.1	-0.4
Reaction time mean minus median AUC	0.2	0.3	0.9	-0.3	-0.2	1.0	0.6	-0.5	-0.7	0.7	0.4	0.3	-0.4
Reaction time num false alarms	4.4	5.9	13.2	3.5	2.0	-3.6	-3.3	2.5	1.8	-1.8	-1.8	-1.6	0.9
Reaction time num false alarms AUC	4.8	6.7	11.7	3.4	2.2	-3.1	-3.2	2.7	2.2	-2.2	-2.2	-2.2	1.7
Reaction time trials correct on left	0.5	0.8	1.7	0.6	0.2	-0.5	-0.7	0.9	1.1	-1.1	-0.9	-0.9	1.3
Reaction time trials on left	0.6	0.9	1.9	0.7	0.3	-0.5	-0.7	1.0	1.2	-1.2	-1.0	-1.0	1.4
Reaction time mean	0.3	0.4	0.6	-0.7	-0.4	0.6	0.8	-0.7	-0.6	0.6	0.3	0.5	-0.6
Reaction time mean AUC	0.6	0.8	1.2	-1.0	-0.8	0.9	1.1	-1.0	-0.9	0.9	0.7	0.7	-0.8
Median of all reaction times	0.2	0.3	0.4	-0.5	-0.6	0.3	0.6	-0.6	-0.6	0.6	0.3	0.4	-0.5
Reaction time omissions	0.4	0.5	0.7	0.7	0.5	-0.5	-0.7	0.6	0.8	-0.8	-0.8	-0.7	0.8
Reaction time false alarm rate	1.6	2.3	5.2	2.3	1.3	-2.2	-2.1	1.6	0.9	-0.9	-1.0	-1.0	0.6
Reaction time premature initiation rate	0.4	0.6	1.2	-1.0	0.3	1.0	1.1	-0.7	-0.5	0.5	0.4	0.4	-1.1
Reaction time premature initiations	0.1	0.1	0.4	-0.6	0.2	0.7	0.6	-0.2	0.1	-0.1	-0.0	-0.0	-0.3
Std. dev. reaction times	0.4	0.6	2.8	-1.0	0.1	1.7	1.1	-0.7	-0.4	0.4	0.2	0.4	-0.4
Reaction time trials completed	0.6	0.9	1.9	0.7	0.3	-0.5	-0.7	1.0	1.2	-1.2	-1.0	-1.0	1.4
Reaction time trials AUC	0.5	0.8	1.6	0.7	0.1	-0.7	-0.7	0.9	1.1	-1.1	-0.9	-0.8	1.3
Run reversals in cocaine runway, females	0.5	0.4	1.1	0.8	1.0	-0.7	-0.6	0.7	0.6	-0.6	-0.5	-0.7	0.0
Run reversals in cocaine runway, males	3.3	3.2	4.4	-2.0	-2.1	1.5	1.9	-2.1	-1.7	1.7	1.8	1.8	-0.9
Latency to leave start box in cocaine runway	2.8	3.0	7.3	2.1	2.7	-1.7	-2.2	1.7	1.4	-1.4	-1.4	-1.5	0.1
Latency to leave start box in cocaine runway, F	3.9	4.3	7.8	2.3	2.8	-1.9	-2.4	1.9	2.1	-2.1	-2.0	-1.9	0.8
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	0.9	0.7	-0.5	-0.7	0.4	-0.4	0.4	0.4	-0.2	-0.5
Std. dev. time between licks in bursts	2.4	2.9	4.5	1.8	2.1	-1.0	-1.8	1.9	1.6	-1.6	-1.8	-1.9	1.2
Total sessions with >9 infusions	0.3	0.4	1.3	0.8	0.3	-1.1	-0.7	0.4	0.6	-0.6	-0.5	-0.1	0.4
Short access day 1 total inactive lever presses	1.7	1.9	3.3	-0.7	-1.5	-0.3	0.9	-1.6	-1.7	1.7	1.7	1.4	-1.8
Short access day 10 total inactive lever presses	3.6	4.0	6.6	-1.2	-2.1	0.2	1.3	-2.1	-2.5	2.5	2.3	2.0	-2.6
Short access day 1 total infusions	0.1	0.1	0.3	0.3	-0.5	-0.1	0.1	-0.4	-0.4	0.4	0.5	0.1	-0.2
Short access day 10 total infusions	0.0	0.0	0.1	0.1	0.0	-0.1	-0.0	-0.3	-0.1	0.1	-0.0	0.2	-0.3
Short access total infusions	0.0	0.0	0.1	0.2	0.1	-0.1	-0.0	-0.3	0.0	-0.0	-0.0	0.1	-0.2
Short access day 1 locomotion	0.4	0.5	1.2	0.7	1.0	-1.1	-0.9	0.1	0.7	-0.7	-0.5	-0.3	-0.2
Short access day 10 total locomotion	0.8	0.9	1.9	1.2	1.4	-0.8	-1.1	0.9	0.8	-0.8	-0.9	-1.0	0.2
Short access total locomotion	2.0	2.0	3.2	1.7	1.8	-1.3	-1.7	1.1	1.4	-1.4	-1.5	-1.3	0.7
One hour access (0.3 mA shock)	0.1	0.2	0.8	0.3	0.3	-0.9	-0.5	0.1	0.3	-0.3	-0.5	0.3	0.0
Compulsive drug intake	0.5	0.5	1.1	-0.5	-1.0	-0.2	0.4	-0.6	-0.8	0.8	1.0	0.7	-0.6
One hour access (shock baseline)	0.5	0.5	1.0	0.7	0.9	-0.7	-0.8	0.7	0.8	-0.8	-1.0	-0.3	0.4
Social response proportion	0.6	0.6	2.0	-0.7	-1.4	0.9	1.0	-0.5	-0.6	0.6	0.7	0.2	0.4
Social responses	0.5	0.7	2.8	0.6	0.2	0.4	-0.3	0.8	0.8	-0.8	-0.5	-1.1	1.7
Social time	3.0	4.0	6.2	1.8	2.1	-0.3	-1.7	2.2	2.0	-2.0	-2.0	-2.5	2.5
Soleus weight	3.0	8.8	11.8	-2.5	-2.3	1.8	2.8	-3.1	-3.3	3.3	3.4	3.3	-3.3
Bone: stiffness	0.2	0.3	1.3	0.7	1.1	-0.6	-0.8	0.4	-0.0	0.0	0.1	-0.0	-0.7
Tibialis anterior weight	1.0	3.3	4.3	-1.8	-1.7	1.7	1.9	-2.1	-1.9	1.9	2.0	1.7	-1.4
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.3	-0.7	-1.1	-0.1	0.6	-1.0	-1.0	1.0	1.1	1.0	-1.1
Time to tail flick, vehicle, after self-admin	1.2	1.3	4.1	1.0	2.0	-0.1	-0.8	1.2	1.3	-1.3	-1.2	-1.0	0.5
Time to tail flick, test, before self-admin	3.0	2.9	6.5	1.0	2.6	0.3	-1.0	1.6	2.0	-2.0	-1.8	-2.1	1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.1	-0.2	-0.6	-0.3	0.2	0.2	-0.2	-0.1	-0.0	0.4
Delta time to tail flick, vehicle, before/after SA	3.9	3.8	8.2	1.2	2.9	0.7	-1.0	1.9	2.3	-2.3	-2.3	-2.1	1.9
Delta time to tail flick, test, before/after SA	0.6	0.5	1.4	0.1	-1.2	-1.1	-0.2	-0.3	-0.7	0.7	0.6	1.0	-0.4
Tibia length	1.7	4.7	11.3	0.9	3.4	0.2	-1.0	2.3	2.6	-2.6	-2.5	-2.4	1.9
Ambulatory time before self-admin	3.5	3.6	5.8	-0.8	-2.1	0.6	1.2	-2.3	-2.4	2.4	2.2	1.9	-2.1
Ambulatory time after self-admin	1.2	1.3	5.3	-0.4	-0.0	0.2	0.4	-1.0	-1.2	1.2	1.1	1.4	-2.3
Bone: tissue strength	0.8	0.8	3.9	-1.1	0.1	2.0	1.3	-0.3	0.2	-0.2	-0.3	-0.3	0.6
Total heroin consumption	0.4	0.4	0.9	-0.6	-0.9	0.6	0.6	-0.6	-0.7	0.7	0.6	0.5	-0.3
Bone: trabecular number	2.5	3.8	7.3	2.6	2.2	-2.4	-2.7	2.3	1.6	-1.6	-1.0	-1.4	0.8
Bone: trabecular spacing	1.2	1.5	3.9	-1.9	-1.1	2.0	1.9	-1.4	-0.6	0.6	0.3	0.4	0.1
Bone: trabecular thickness	0.3	0.4	1.1	0.6	0.7	-1.0	-0.8	0.3	-0.1	0.1	0.4	0.4	-0.9
Bone: trabecular tissue density	0.3	0.4	1.5	-0.9	0.8	1.2	0.7	-0.4	-0.1	0.1	0.2	0.3	-0.5
Water consumed over 24 hours	0.3	0.4	1.1	-0.4	-1.1	0.5	0.6	-0.6	-0.6	0.6	0.8	0.6	-0.1
Number of responses in last shaping day	0.3	0.4	0.6	0.6	0.6	-0.4	-0.7	0.4	0.6	-0.6	-0.5	-0.6	0.8