Hub : Genes

Clns1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Clns1a 0.31 0.17 2.0e-03 0.02 0.02 0.03 0.02 1.3e-01 8.9e-02 6.9e-02 1.1e-01
2 Brain mRNA stability Clns1a 0.38 0.15 0.0e+00 0.31 0.31 0.32 0.32 1.2e-29 2.6e-29 3.0e-30 1.8e-30
3 NAcc mRNA stability Clns1a 0.04 0.03 1.5e-04 0.05 0.03 0.04 0.05 2.3e-06 6.6e-05 5.7e-05 4.1e-06
4 LHb mRNA stability Clns1a 0.2 0.12 5.0e-03 0.08 0.07 0.06 0.06 5.7e-03 1.0e-02 1.9e-02 1.6e-02
5 OFC mRNA stability Clns1a 0.19 0.11 1.7e-03 0.05 0.02 -0.01 0.01 2.9e-02 1.3e-01 9.6e-01 1.5e-01
6 PL alternative TSS NM_031719.2 0.03 0.02 2.0e-03 0.03 0.02 0.02 0.02 3.5e-04 2.1e-03 5.1e-03 1.1e-03
7 PL alternative TSS XM_006229792.2 0.03 0.02 2.4e-03 0.03 0.02 0.01 0.02 4.8e-04 2.8e-03 7.9e-03 1.7e-03
8 PL mRNA stability Clns1a 0.07 0.05 1.2e-06 0.05 0.05 0.04 0.05 2.0e-06 5.0e-06 3.1e-05 5.5e-06
9 BLA mRNA stability Clns1a 0.17 0.1 3.8e-05 0.05 0.07 0.03 0.05 1.1e-03 9.7e-05 1.6e-02 7.4e-04
10 NAcc gene expression Clns1a 0.04 0.03 4.8e-04 0.03 0.03 0.02 0.02 4.2e-04 2.4e-04 7.5e-04 6.7e-04
11 Liver mRNA stability Clns1a 0.06 0.06 7.5e-03 -0 0 0.02 -0 6.2e-01 1.5e-01 6.1e-03 4.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.10.10.40.2-0.30.40.40.4-0.20.20.2-0.30.60.1
Area under the delay curve1.61.72.51.2-1.31.51.51.5-1.51.51.6-1.20.60.4
BMI with tail1.65.27.0-2.72.4-2.4-2.4-2.42.5-2.5-2.51.9-2.10.4
BMI without tail8.217.020.8-4.44.5-4.3-4.3-4.34.2-4.2-4.63.9-4.30.0
Body weight2.912.316.3-3.93.8-3.6-3.6-3.63.5-3.5-3.73.3-4.00.1
Weight adjusted by age0.40.42.6-0.30.5-0.5-0.5-0.50.5-0.5-0.50.3-1.6-0.3
Bone surface0.91.62.71.2-1.31.61.61.6-1.11.11.3-1.40.0-0.4
Bone volume0.30.51.00.6-0.70.90.90.9-0.60.60.6-1.0-0.3-0.2
Breakpoint value in progressive ratio session0.10.20.60.1-0.40.00.00.0-0.00.00.1-0.70.70.8
Number of licking bursts1.92.23.4-1.81.6-1.6-1.6-1.61.7-1.7-1.51.3-0.30.7
Context. condit. distance diff. score2.22.75.41.8-2.01.71.71.7-1.51.51.7-2.31.0-0.2
Locomotion velocity, session 11.51.72.01.4-1.41.31.31.3-1.31.31.4-1.31.4-0.5
Locomotion distance, session 10.60.71.01.0-1.00.90.90.9-1.01.00.9-0.70.6-0.3
Locomotion velocity, session 20.40.40.70.8-0.70.80.80.8-0.50.50.7-0.80.1-0.3
Locomotion distance, session 20.10.11.0-0.10.00.00.00.00.0-0.00.00.3-0.2-1.0
Locomotion velocity, session 30.40.50.60.7-0.70.70.70.7-0.70.70.7-0.60.3-0.8
Locomotion distance, session 32.12.33.61.7-1.81.61.61.6-1.51.51.6-1.91.1-0.5
Stereotopy head waving bouts, day 31.82.15.6-1.51.8-1.4-1.4-1.41.3-1.3-1.42.4-0.9-0.2
Stereotopy head waving duration, day 30.20.22.0-0.10.10.20.20.2-0.20.20.20.60.2-1.4
Locomotion velocity, session 70.40.51.10.7-0.70.60.60.6-0.80.80.6-1.00.50.3
Locomotion distance, session 70.20.31.60.4-0.50.20.20.2-0.30.30.2-1.3-0.10.8
Stereotopy head waving bouts, day 70.50.61.60.8-0.70.80.80.8-0.70.70.9-0.00.5-1.3
Stereotopy head waving duration, day 70.91.13.70.9-0.81.11.11.1-1.01.01.1-0.10.1-1.9
Locomotion velocity, session 85.76.912.22.7-3.12.72.72.7-2.52.52.7-3.51.7-1.2
Locomotion distance, session 81.11.72.41.4-1.51.31.31.3-1.31.31.4-1.50.6-0.9
Degree of sensitization distance2.02.03.0-1.41.5-1.5-1.5-1.51.4-1.4-1.51.1-1.70.8
Degree of sensitization stereotypy3.03.24.02.0-2.02.02.02.0-1.81.82.0-1.41.1-1.6
Conditioned locomotion0.20.20.50.3-0.40.40.40.4-0.50.50.2-0.40.7-0.7
Cocaine response after cond. corrected0.30.43.10.10.1-0.3-0.3-0.30.0-0.0-0.4-0.5-0.21.8
Cocaine response after cond. not corrected0.30.32.00.5-0.30.30.30.3-0.40.40.2-0.50.21.4
Cocaine response before conditioning0.60.81.50.6-0.71.11.11.1-0.60.61.20.50.8-0.9
Saline control response0.20.31.2-0.50.2-0.3-0.3-0.30.4-0.4-0.20.3-1.1-1.0
Bone: connectivity density1.11.72.41.3-1.41.61.61.6-1.31.31.3-1.21.30.1
Bone: cortical apparent density0.40.50.8-0.90.8-0.9-0.9-0.90.7-0.7-0.80.4-0.20.4
Bone: cortical area0.20.41.3-0.80.3-0.3-0.3-0.30.8-0.8-0.6-0.2-1.1-0.0
Bone: cortical porosity0.70.81.11.1-0.71.01.01.0-1.01.01.10.20.5-0.6
Bone: cortical porosity0.60.60.90.9-0.60.90.90.9-0.90.90.90.40.5-0.5
Bone: cortical thickness0.30.51.2-1.00.7-0.6-0.6-0.61.1-1.1-0.90.2-0.40.4
Bone: cortical thickness0.50.61.50.9-0.90.70.70.7-0.70.70.7-1.20.20.9
Bone: cortical tissue density0.30.50.7-0.80.8-0.8-0.8-0.80.7-0.7-0.70.4-0.10.4
Condit. Reinf. active minus inactive responses1.92.13.1-1.61.3-1.6-1.6-1.61.8-1.8-1.60.8-1.50.2
Condit. Reinf. active-inactive response ratio1.51.72.3-1.51.2-1.3-1.3-1.31.5-1.5-1.30.9-1.5-0.0
Condit. Reinf. active responses1.72.13.4-1.61.3-1.6-1.6-1.61.8-1.8-1.60.9-1.2-0.2
Condit. Reinf. inactive responses0.20.20.4-0.30.3-0.5-0.5-0.50.7-0.7-0.50.1-0.1-0.5
Incentive salience index mean0.60.71.4-0.90.7-0.9-0.9-0.91.0-1.0-0.90.1-1.20.4
Condit. Reinf. lever presses0.20.31.00.6-0.60.50.50.5-0.50.50.5-1.00.00.2
Condit. Reinf. active minus inactive responses0.60.82.40.7-0.80.80.80.8-0.60.60.9-0.8-1.5-0.9
Condit. Reinf. active-inactive response ratio0.50.51.60.7-0.90.70.70.7-0.70.70.7-1.3-0.4-0.3
Condit. Reinf. active responses0.81.14.90.8-0.81.01.01.0-0.70.71.0-0.5-2.2-1.1
Condit. Reinf. inactive responses0.50.74.20.10.20.50.50.5-0.10.10.41.0-2.0-1.1
Condit. Reinf. lever presses5.57.59.22.9-2.93.03.03.0-2.82.83.0-2.2-0.5-3.0
Condit. Reinf. lever reinforcers received0.91.34.21.0-1.01.11.11.1-0.90.91.1-0.7-2.1-1.1
Conditioned reinforcement - actives3.63.65.82.4-1.92.12.12.1-2.12.11.7-1.81.1-0.1
Conditioned reinforcement - inactives0.10.10.20.5-0.30.40.40.4-0.50.50.2-0.20.30.1
Conditioned locomotion3.13.75.42.3-2.12.12.12.1-2.12.11.9-1.81.3-0.5
Patch foraging indifference point 0 sec0.40.62.40.6-0.80.70.70.7-0.50.50.7-0.4-0.6-1.5
Patch foraging indifference point AUC0.10.10.2-0.30.2-0.4-0.4-0.40.5-0.5-0.3-0.1-0.40.4
Delay disc. indifference point, 0s delay0.10.10.30.4-0.20.30.30.3-0.40.40.3-0.1-0.50.4
Delay disc. indifference point, 16s delay2.82.94.71.3-1.62.12.12.1-1.81.82.2-1.21.2-0.6
Delay disc. indifference point, 2s delay0.60.61.70.8-1.10.80.80.8-0.60.61.3-0.70.1-0.6
Delay disc. indifference point, 24s delay0.40.30.50.2-0.50.70.70.7-0.60.60.7-0.70.7-0.0
Delay disc. indifference point, 4s delay0.60.60.90.8-0.70.80.80.8-0.90.90.8-0.8-0.60.0
Delay disc. indifference point, 8s delay2.02.12.91.5-1.41.61.61.6-1.71.71.5-1.40.80.7
Indifference point function ln k1.52.02.91.4-1.31.61.61.6-1.71.71.5-0.50.9-1.4
Indifference point function log k1.52.02.91.4-1.31.61.61.6-1.71.71.5-0.50.9-1.4
Patch foraging total patch changes 0 sec0.30.52.00.5-0.80.70.70.7-0.40.40.7-0.5-0.5-1.4
Patch foraging total patch changes 12 sec0.30.31.4-0.20.4-0.6-0.6-0.60.6-0.6-0.60.1-1.20.2
Patch foraging total patch changes 18 sec0.10.11.10.3-0.2-0.0-0.0-0.00.1-0.10.1-0.3-1.0-0.1
Patch foraging total patch changes 24 sec0.40.51.1-0.30.4-0.7-0.7-0.70.8-0.8-0.60.0-1.11.0
Patch foraging total patch changes 6 sec0.00.10.2-0.1-0.30.30.30.3-0.00.00.40.00.1-0.4
Patch foraging time to switch 0 sec0.81.31.9-1.11.4-1.1-1.1-1.10.9-0.9-1.31.30.41.3
Patch foraging water rate 0 sec0.81.31.91.3-1.41.21.21.2-1.11.11.2-1.3-0.1-1.2
Patch foraging water rate 12 sec1.01.62.11.1-1.41.41.41.4-1.21.21.3-1.20.4-1.4
Patch foraging water rate 18 sec0.30.30.80.4-0.80.60.60.6-0.40.40.7-0.9-0.2-0.5
Patch foraging water rate 24 sec1.52.13.31.4-1.81.41.41.4-1.41.41.4-1.71.3-0.9
Patch foraging water rate 6 sec1.11.62.01.4-1.41.41.41.4-1.21.21.4-1.11.0-0.9
Seeking ratio, delayed vs. immediate footshock0.30.32.30.2-0.20.40.40.4-0.10.10.4-0.50.31.5
Distance traveled before self-admin0.10.10.2-0.40.1-0.2-0.2-0.20.4-0.4-0.10.1-0.00.2
Distance traveled after self-admin0.10.10.6-0.40.2-0.1-0.1-0.10.2-0.2-0.20.60.8-0.5
Extensor digitorum longus weight0.21.01.9-1.20.9-0.9-0.9-0.91.3-1.3-1.00.2-1.4-0.2
Bone: elastic displacement0.20.20.80.1-0.20.30.30.3-0.30.30.1-0.30.80.9
Bone: elastic work1.11.43.11.0-1.01.31.31.3-1.31.31.1-1.01.80.2
Bone: endosteal estimation0.10.32.20.2-0.10.40.40.4-0.10.10.2-0.4-1.5-0.4
Bone: endosteal perimeter0.40.81.30.7-0.90.90.90.9-0.70.70.7-1.2-1.1-1.0
Epididymis fat weight2.76.49.7-2.82.9-2.4-2.4-2.42.6-2.6-2.62.4-3.11.3
Delta time in closed arm before/after self-admin0.30.30.9-0.70.5-0.5-0.5-0.50.4-0.4-0.5-0.2-0.9-0.3
Delta time in open arm before/after self-admin0.10.10.30.4-0.30.40.40.4-0.30.30.0-0.4-0.6-0.1
Diff in mean of infusions in LGA sessions2.32.54.1-2.01.7-1.8-1.8-1.81.8-1.8-1.91.2-0.10.1
Delay discount exponential model param1.51.62.4-1.21.3-1.4-1.4-1.41.4-1.4-1.51.2-0.7-0.4
Extinction: sum of active levers before priming0.10.10.3-0.20.1-0.0-0.0-0.00.2-0.2-0.1-0.2-0.50.4
Active lever presses in extinction session 60.70.71.31.1-0.90.90.90.9-0.90.90.8-0.20.7-0.0
Bone: final force0.10.20.70.3-0.60.50.50.5-0.30.30.4-0.80.4-0.1
Bone: final moment0.10.20.50.3-0.60.60.60.6-0.30.30.4-0.70.3-0.3
Food consumed during 24 hour testing period2.63.14.01.9-1.72.02.02.0-1.71.72.0-1.10.9-2.0
Glucose0.30.41.00.5-0.70.50.50.5-0.60.60.6-1.00.3-0.7
Heart weight0.60.81.21.1-1.00.90.90.9-1.01.00.8-1.00.00.7
Delay discount hyperbolic model param1.41.52.2-1.21.3-1.4-1.4-1.41.3-1.3-1.51.2-0.5-0.3
Intermittent access intake day 1-15 change3.93.95.62.2-2.02.42.42.4-2.22.22.1-1.51.0-0.1
Intermittent access intake escalation4.34.36.22.3-2.12.52.52.5-2.32.32.2-1.60.9-0.3
Intermittent access intake escalation 20.70.61.01.0-0.71.01.01.0-0.80.80.9-0.4-0.00.1
Intermitt. access day 1 inactive lever presses0.20.20.5-0.20.4-0.5-0.5-0.50.4-0.4-0.40.7-0.10.3
Intermitt. access day 15 inactive lever presses0.10.20.30.5-0.40.40.40.4-0.50.50.5-0.20.3-0.1
Intermitt. access escalation Index0.00.00.2-0.20.10.00.00.00.1-0.10.10.40.2-0.3
Intermittent access day 1 total infusions0.40.51.00.9-0.70.70.70.7-0.80.80.5-1.0-0.10.3
Intermittent access day 15 total infusions4.85.47.52.7-2.32.72.72.7-2.72.72.3-2.10.90.0
Intermittent access terminal intake (last 3 days)2.42.64.12.0-1.51.91.91.9-1.91.91.6-1.40.30.0
Intermittent access total infusions1.21.42.51.6-1.11.31.31.3-1.41.40.9-1.20.10.4
Intermittent access day 1 locomotion0.40.50.80.9-0.70.60.60.6-0.80.80.4-0.80.70.5
Intermittent access day 15 total locomotion1.41.52.21.5-1.31.41.41.4-1.41.41.4-1.00.2-0.1
Intermittent access total locomotion0.40.51.01.0-0.60.70.70.7-0.80.80.4-0.7-0.1-0.3
Intermittent access standard deviation0.10.10.40.5-0.00.30.30.3-0.40.4-0.10.0-0.30.7
Left kidney weight0.51.36.8-0.71.3-0.8-0.8-0.80.7-0.7-0.91.2-2.6-0.2
Right kidney weight0.41.14.9-0.81.2-0.7-0.7-0.70.7-0.7-0.71.4-2.2-0.4
Cocaine induced anxiety0.70.81.3-1.01.0-1.1-1.1-1.10.9-0.9-1.20.80.10.0
Post-drug Anxiety0.10.10.5-0.10.2-0.1-0.1-0.1-0.00.0-0.10.10.00.7
Baseline Anxiety2.22.43.61.7-1.81.71.71.7-1.61.61.9-1.40.2-0.4
Tail length2.57.720.6-2.63.0-2.5-2.5-2.52.5-2.5-2.62.9-4.5-1.1
Length with tail1.97.114.1-2.72.9-2.5-2.5-2.52.5-2.5-2.72.8-3.8-0.7
Length without tail0.00.00.2-0.2-0.10.00.00.0-0.00.00.0-0.10.40.2
Times rat made contact with spout1.11.31.7-1.31.2-1.1-1.1-1.11.2-1.2-1.11.3-0.9-0.7
Lifetime Intake1.51.73.21.8-1.21.41.41.4-1.61.61.1-1.30.20.4
Liver weight, left1.22.03.0-1.71.3-1.5-1.5-1.51.7-1.7-1.31.1-1.30.6
Liver weight, right5.59.211.4-3.43.4-3.0-3.0-3.03.2-3.2-3.03.3-2.71.8
Locomotor activity0.40.62.1-0.50.8-0.5-0.5-0.50.4-0.4-0.51.5-0.8-1.1
Locomotor testing distance0.30.52.9-0.30.6-0.5-0.5-0.50.4-0.4-0.41.0-1.7-0.6
Locomotor testing rearing2.74.26.3-1.92.1-2.2-2.2-2.22.1-2.1-2.11.9-2.50.5
Locomotion in novel chamber1.31.62.11.4-1.41.31.31.3-1.31.31.4-1.11.2-0.8
Locomotion in novel chamber post-restriction4.45.37.62.1-2.72.72.72.7-2.22.22.6-2.31.7-0.5
Fecal boli incidents, locomotor time 12.52.74.22.1-1.91.61.61.6-1.81.81.7-1.90.90.6
Change in fecal boli incidents, locomotor task0.50.41.3-1.00.9-0.5-0.5-0.50.6-0.6-0.51.20.20.2
Time >=10cm from walls, locomotor time 11.11.13.01.1-1.20.70.70.7-1.01.00.8-1.01.0-1.7
Bouts of movement, locomotor time 10.20.20.50.2-0.60.50.50.5-0.30.30.2-0.70.2-0.4
Total resting periods, locomotor time 10.50.51.00.5-0.90.80.80.8-0.60.60.5-1.00.8-0.0
Rest time, locomotor task time 11.11.21.70.9-1.21.11.11.1-1.01.01.1-1.21.11.3
Distance moved, locomotor task time 10.70.82.6-0.50.9-0.9-0.9-0.90.6-0.6-0.90.7-1.6-1.0
Vertical activity count, locomotor time 10.40.41.6-0.30.4-0.5-0.5-0.50.3-0.3-0.30.5-1.1-1.3
Time >=10cm from walls, locomotor time 20.10.10.30.3-0.3-0.3-0.3-0.3-0.10.1-0.2-0.5-0.4-0.4
Bouts of movement, locomotor time 20.70.81.60.6-0.41.31.31.3-0.70.71.10.4-0.6-0.8
Total resting periods, locomotor time 20.70.71.60.6-0.41.31.31.3-0.70.71.10.2-0.4-0.6
Rest time, locomotor task time 20.60.72.4-0.70.7-0.7-0.7-0.70.8-0.8-0.70.60.71.5
Distance moved, locomotor task time 20.40.42.00.6-0.30.20.20.2-0.50.50.1-0.5-1.4-1.1
Vertical activity count, locomotor time 20.30.32.30.10.0-0.3-0.3-0.3-0.10.1-0.1-0.1-1.5-0.7
Light reinforcement 12.03.74.7-2.21.9-2.1-2.1-2.12.1-2.1-2.11.7-0.71.6
Light reinforcement 20.30.50.8-0.60.5-0.9-0.9-0.90.7-0.7-0.80.60.10.3
Bone: marrow area0.10.22.10.00.00.30.30.3-0.00.00.1-0.2-1.4-0.3
Bone: maximum diameter0.20.41.20.2-0.60.50.50.5-0.20.20.4-0.8-1.0-1.1
Bone: maximum force0.50.91.60.7-1.11.11.11.1-0.80.80.9-1.30.8-0.7
Bone: maximum moment0.61.01.50.7-1.11.21.21.2-0.90.90.9-1.20.6-0.9
Mean time between licks in bursts0.70.94.90.9-0.30.80.80.8-0.80.81.00.3-2.2-0.5
Mean num. licks in bursts1.21.51.91.4-1.31.31.31.3-1.31.31.2-1.1-0.0-1.2
Cd content in liver1.11.22.0-1.21.0-1.2-1.2-1.21.4-1.4-1.20.6-0.60.9
Co content in liver0.10.21.00.3-0.10.00.00.0-0.20.2-0.0-0.6-1.00.3
Cu content in liver0.30.42.7-0.20.7-0.5-0.5-0.50.1-0.1-0.50.5-1.6-0.0
Fe content in liver0.50.61.10.9-0.60.70.70.7-0.90.90.7-0.8-0.11.0
K content in liver0.20.21.1-0.30.50.20.20.20.2-0.20.21.0-0.30.2
Mg content in liver0.30.30.80.3-0.30.90.90.9-0.30.30.80.1-0.2-0.2
Mn content in liver0.20.21.60.2-0.20.30.30.3-0.20.20.3-0.11.20.6
Na content in liver0.80.81.41.0-0.61.21.21.2-0.90.91.10.30.7-0.3
Rb content in liver0.20.20.70.1-0.30.40.40.4-0.40.40.3-0.4-0.6-0.8
Se content in liver0.50.63.1-0.40.7-0.5-0.5-0.50.6-0.6-0.60.80.71.8
Sr content in liver0.90.81.30.9-1.01.01.01.0-0.80.81.1-1.10.6-0.2
Zn content in liver0.70.71.00.7-0.61.01.01.0-0.80.81.0-0.2-0.9-0.9
Bone: minimum diameter0.61.23.9-1.31.0-0.6-0.6-0.61.3-1.3-1.10.4-2.00.1
Time in familiar zone, hab. session 10.10.10.2-0.0-0.0-0.1-0.1-0.10.3-0.3-0.1-0.30.10.5
Time in novel zone, hab. session 10.40.40.6-0.70.7-0.6-0.6-0.60.4-0.4-0.60.8-0.7-0.1
Total zone transitions, hab. session 10.20.31.6-0.0-0.30.20.20.2-0.30.30.30.21.1-1.3
Total locomotion distance, hab. session 17.010.012.9-3.33.5-3.4-3.4-3.43.4-3.4-3.43.6-2.10.7
Locomotion velocity, hab. session 16.18.611.5-3.03.2-3.1-3.1-3.13.2-3.2-3.13.4-1.90.7
Time in familiar zone, hab. session 20.20.20.90.2-0.30.40.40.4-0.30.30.4-0.5-0.5-0.9
Time in novel zone, hab. session 20.10.10.80.2-0.2-0.0-0.0-0.0-0.00.0-0.0-0.20.20.9
Total zone transitions, hab. session 20.30.32.20.0-0.50.30.30.3-0.30.30.30.10.8-1.5
Total locomotion distance, hab. session 25.16.88.8-2.82.8-2.8-2.8-2.82.7-2.7-2.83.0-2.00.5
Locomotion velocity, hab. session 25.87.89.7-3.03.0-3.0-3.0-3.03.0-3.0-3.03.1-2.10.5
Novel to familiar place preference ratio0.10.10.2-0.30.0-0.2-0.2-0.20.2-0.2-0.20.40.0-0.3
Novelty place preference0.00.00.0-0.1-0.1-0.1-0.1-0.10.1-0.1-0.10.2-0.0-0.2
Time in novel zone, NPP test0.00.00.10.1-0.30.10.10.1-0.10.10.2-0.10.1-0.4
Total zone transitions, NPP test0.60.91.50.9-1.10.90.90.9-1.01.00.9-0.91.2-0.5
Total locomotion distance, NPP test3.95.46.3-2.22.4-2.5-2.5-2.52.5-2.5-2.52.2-1.71.8
Locomotion velocity, NPP test4.96.98.1-2.52.7-2.8-2.8-2.82.8-2.8-2.82.5-1.82.0
Intraocular pressure3.85.410.82.4-2.82.32.32.3-2.32.32.2-3.31.7-0.9
Delta distance traveled before/after self-admin0.20.20.60.30.10.40.40.4-0.50.50.10.60.5-0.8
Delta ambulatory time before/after self-admin0.50.51.80.5-0.30.60.60.6-0.70.70.30.21.0-1.3
Parametrial fat weight3.05.87.9-2.82.5-2.6-2.6-2.62.7-2.7-2.72.3-1.50.6
Pavlov. Cond. lever latency0.81.01.5-1.20.8-1.1-1.1-1.11.1-1.1-1.10.80.20.5
Pavlov. Cond. magazine entry latency0.30.31.20.5-0.40.40.40.4-0.40.40.5-0.4-0.9-1.1
Pavlov. Cond. change in total contacts0.50.51.01.0-0.70.70.70.7-0.60.60.7-1.0-0.40.2
Pavlov. Cond. index score0.60.71.01.0-0.60.90.90.9-0.90.90.9-0.7-1.0-0.7
Pavlov. Cond. latency score0.50.70.91.0-0.60.90.90.9-0.90.90.9-0.6-0.9-0.7
Pavlov. Cond. lever contacts0.50.60.91.0-0.50.90.90.9-0.90.90.8-0.7-0.6-0.3
Pavlov. Cond. magazine entry number0.50.71.3-0.80.7-0.8-0.8-0.80.7-0.7-0.80.70.81.1
Pavlov. Cond. intertrial magazine entries0.81.01.4-0.91.0-1.1-1.1-1.11.2-1.2-1.10.8-0.20.8
Pavlov. Cond. lever-magazine prob. diff.0.70.81.11.1-0.71.01.01.0-1.01.01.0-0.7-0.8-0.7
Pavlov. Cond. response bias0.20.20.50.6-0.20.50.50.5-0.40.40.5-0.3-0.7-0.3
Pavlov. Cond. lever latency7.19.612.0-3.33.5-3.3-3.3-3.33.2-3.2-3.42.90.12.9
Pavlov. Cond. magazine entry latency3.54.06.32.2-2.51.91.91.9-2.12.11.9-2.51.0-1.3
Pavlov. Cond. change in total contacts3.85.26.62.5-2.62.42.42.4-2.32.32.5-2.1-0.2-2.3
Pavlov. Cond. index score6.07.710.03.1-3.22.92.92.9-3.03.02.9-2.90.2-2.4
Pavlov. Cond. latency score5.77.19.63.0-3.12.72.72.7-2.92.92.8-2.80.4-2.3
Pavlov. Cond. lever contacts6.38.610.63.1-3.33.13.13.1-3.13.13.2-2.6-0.3-3.0
Pavlov. Cond. magazine entry number6.58.014.3-3.23.4-2.8-2.8-2.83.0-3.0-2.93.8-0.91.3
Pavlov. Cond. intertrial magazine entries2.73.56.1-2.02.2-1.7-1.7-1.71.8-1.8-1.72.5-2.3-0.1
Pavlov. Cond. lever-magazine prob. diff.5.36.88.83.0-3.02.72.72.7-2.82.82.7-2.70.0-2.2
Pavlov. Cond. response bias7.510.212.73.5-3.63.43.43.4-3.43.43.5-3.0-0.1-2.7
Time in closed arm before self-admin1.71.92.71.6-1.41.41.41.4-1.61.61.6-0.61.3-0.3
Time in closed arm after self-admin2.42.43.41.5-1.61.61.61.6-1.71.71.6-1.61.8-0.3
Time in open arm before self-admin1.31.42.1-1.51.3-1.2-1.2-1.21.4-1.4-1.10.9-0.30.8
Time in open arm after self-admin1.61.82.2-1.41.4-1.4-1.4-1.41.5-1.5-1.51.0-1.4-0.0
Bone: periosteal estimation0.20.32.10.0-0.20.50.50.50.0-0.00.1-0.8-1.5-0.4
Bone: periosteal perimeter0.30.52.0-0.0-0.40.70.70.7-0.10.10.3-0.5-1.1-1.4
Bone: post-yield work0.30.41.70.2-0.40.70.70.7-0.30.30.5-0.10.5-1.3
Progressive ratio test 1 active lever presses0.10.10.20.4-0.00.00.00.0-0.40.4-0.1-0.10.40.5
Progressive ratio test 1 breakpoint0.10.10.20.20.1-0.1-0.1-0.1-0.20.2-0.3-0.00.40.4
Progressive ratio test 1 inactive lever presses0.10.10.40.6-0.10.30.30.3-0.50.5-0.0-0.1-0.10.0
Progressive ratio test 2 active lever presses0.70.71.41.2-0.80.90.90.9-1.01.00.7-1.1-0.7-0.4
Progressive ratio test 2 breakpoint0.40.50.90.9-0.50.60.60.6-0.80.80.5-0.8-0.8-0.2
Progressive ratio test 2 inactive lever presses0.70.81.51.2-0.71.01.01.0-1.11.10.7-0.8-0.3-0.9
Incentive Sensitization - Responses0.80.91.21.1-0.91.01.01.0-0.90.91.1-0.9-1.0-0.3
Incentive Sensitization - Breakpoint1.01.01.41.1-0.91.11.11.1-0.90.91.2-0.9-0.9-0.3
Sum of active levers in priming session hrs 5-60.50.50.7-0.80.7-0.6-0.6-0.60.8-0.8-0.60.8-0.5-0.6
Progressive ratio0.91.12.80.9-1.30.90.90.9-0.90.90.7-1.71.2-0.5
Food seeking constrained by brief footshock0.40.41.8-0.50.5-0.6-0.6-0.60.5-0.5-0.50.8-1.3-0.5
Seeking ratio, punishment vs. effort1.72.05.0-1.11.6-1.2-1.2-1.21.2-1.2-1.02.2-2.20.3
Retroperitoneal fat weight8.026.233.4-5.85.6-5.4-5.4-5.45.4-5.4-5.54.3-5.02.2
Reaction time number correct0.10.21.0-0.1-0.0-0.1-0.1-0.10.0-0.0-0.00.61.0-0.9
Reaction time mean minus median0.10.20.8-0.30.2-0.1-0.1-0.10.2-0.20.10.4-0.9-0.8
Reaction time mean minus median AUC0.10.11.0-0.1-0.20.10.10.1-0.00.00.30.3-0.4-1.0
Reaction time num false alarms1.62.13.3-1.71.4-1.7-1.7-1.71.7-1.7-1.80.6-0.50.2
Reaction time num false alarms AUC0.30.40.7-0.80.6-0.7-0.7-0.70.8-0.8-0.8-0.0-0.00.1
Reaction time trials correct on left0.10.21.0-0.1-0.0-0.1-0.1-0.10.0-0.0-0.00.61.0-0.9
Reaction time trials on left0.10.21.0-0.1-0.0-0.1-0.1-0.1-0.00.00.00.61.0-0.9
Reaction time mean0.30.40.6-0.70.6-0.5-0.5-0.50.8-0.8-0.40.8-0.60.2
Reaction time mean AUC0.10.20.4-0.60.4-0.4-0.4-0.40.6-0.6-0.30.5-0.20.2
Median of all reaction times0.10.20.3-0.40.4-0.3-0.3-0.30.5-0.5-0.20.5-0.10.5
Reaction time omissions0.10.11.1-0.0-0.00.20.20.2-0.00.00.20.1-0.61.0
Reaction time false alarm rate0.30.50.7-0.70.5-0.7-0.7-0.70.8-0.8-0.8-0.3-0.40.8
Reaction time premature initiation rate1.62.17.3-1.31.5-1.1-1.1-1.11.3-1.3-1.11.7-2.70.8
Reaction time premature initiations0.81.13.4-0.91.1-0.8-0.8-0.80.9-0.9-0.81.7-1.90.3
Std. dev. reaction times0.30.52.0-0.70.6-0.5-0.5-0.50.7-0.7-0.30.7-1.4-0.1
Reaction time trials completed0.10.21.0-0.1-0.0-0.1-0.1-0.1-0.00.00.00.61.0-0.9
Reaction time trials AUC0.10.20.8-0.30.2-0.3-0.3-0.30.2-0.2-0.20.70.7-0.9
Run reversals in cocaine runway, females2.82.75.1-1.81.6-1.8-1.8-1.81.7-1.7-1.70.8-2.3-0.3
Run reversals in cocaine runway, males2.52.43.41.6-1.61.81.81.8-1.81.81.2-1.91.20.0
Latency to leave start box in cocaine runway1.21.32.4-0.91.2-1.2-1.2-1.21.1-1.1-1.31.2-0.31.5
Latency to leave start box in cocaine runway, F1.81.93.5-1.01.4-1.5-1.5-1.51.4-1.4-1.61.1-0.81.9
Latency to leave start box in cocaine runway, M0.10.10.70.2-0.00.20.20.2-0.30.30.30.50.90.2
Std. dev. time between licks in bursts1.21.44.1-1.21.2-0.9-0.9-0.91.2-1.2-0.71.6-2.0-0.2
Total sessions with >9 infusions1.51.73.01.7-1.21.41.41.4-1.51.51.2-0.80.41.1
Short access day 1 total inactive lever presses0.30.40.70.8-0.60.60.60.6-0.70.70.3-0.80.2-0.1
Short access day 10 total inactive lever presses0.60.71.5-1.00.7-0.8-0.8-0.80.9-0.9-0.71.2-0.20.9
Short access day 1 total infusions1.01.02.11.5-0.91.11.11.1-1.21.20.9-0.6-0.30.7
Short access day 10 total infusions0.50.61.01.0-0.60.60.60.6-0.80.80.5-1.0-0.21.0
Short access total infusions0.50.61.41.1-0.50.70.70.7-0.90.90.3-0.6-0.11.2
Short access day 1 locomotion3.94.25.52.3-2.22.32.32.3-2.32.32.1-1.81.40.0
Short access day 10 total locomotion0.10.10.30.4-0.30.40.40.4-0.30.30.4-0.1-0.20.6
Short access total locomotion0.10.20.60.5-0.30.30.30.3-0.30.30.30.10.30.8
One hour access (0.3 mA shock)1.21.42.31.5-1.01.31.31.3-1.31.31.1-1.0-0.70.1
Compulsive drug intake0.10.10.9-0.00.0-0.0-0.0-0.00.2-0.20.10.2-0.00.9
One hour access (shock baseline)1.21.41.91.4-1.11.31.31.3-1.31.31.1-1.0-0.1-1.0
Social response proportion1.51.63.6-1.41.5-1.2-1.2-1.21.4-1.4-1.21.9-0.70.2
Social responses2.12.73.8-2.01.8-1.6-1.6-1.61.9-1.9-1.51.8-1.50.7
Social time0.91.22.8-1.21.1-0.9-0.9-0.91.2-1.2-0.91.30.11.7
Soleus weight0.92.74.8-1.71.9-1.6-1.6-1.61.7-1.7-1.71.4-2.2-0.4
Bone: stiffness0.10.10.2-0.4-0.1-0.1-0.1-0.10.4-0.4-0.2-0.40.4-0.4
Tibialis anterior weight0.31.11.6-1.20.9-0.9-0.9-0.91.3-1.3-1.00.9-1.0-1.0
Time to tail flick, vehicle, before self-admin0.30.30.6-0.50.7-0.5-0.5-0.50.4-0.4-0.40.7-0.50.7
Time to tail flick, vehicle, after self-admin2.32.53.51.7-1.61.91.91.9-1.81.81.6-1.30.8-0.6
Time to tail flick, test, before self-admin0.50.50.9-0.60.1-0.8-0.8-0.80.6-0.6-0.9-0.9-0.1-0.8
Time to tail flick, test, after self-admin0.20.20.5-0.10.0-0.4-0.4-0.40.2-0.2-0.5-0.5-0.7-0.5
Delta time to tail flick, vehicle, before/after SA4.34.25.32.3-2.22.32.32.3-2.22.22.1-1.81.4-1.0
Delta time to tail flick, test, before/after SA0.00.00.20.10.00.20.20.2-0.10.10.20.50.00.3
Tibia length0.61.62.41.5-1.51.31.31.3-1.51.51.4-1.20.8-0.3
Ambulatory time before self-admin0.10.10.40.1-0.40.20.20.2-0.10.10.1-0.60.60.3
Ambulatory time after self-admin0.30.41.80.2-0.40.40.40.4-0.40.40.30.01.4-1.0
Bone: tissue strength0.70.72.40.3-0.50.90.90.9-0.60.60.60.11.6-0.9
Total heroin consumption0.00.00.1-0.1-0.20.10.10.10.0-0.00.3-0.30.30.4
Bone: trabecular number0.20.31.30.2-0.30.40.40.4-0.40.40.3-0.51.10.7
Bone: trabecular spacing0.20.20.60.8-0.60.40.40.4-0.60.60.6-0.1-0.1-0.3
Bone: trabecular thickness0.40.40.9-0.90.6-0.7-0.7-0.70.8-0.8-0.70.1-0.6-0.1
Bone: trabecular tissue density3.85.37.5-2.52.4-2.7-2.7-2.72.4-2.4-2.42.2-1.40.1
Water consumed over 24 hours0.40.50.7-0.80.8-0.8-0.8-0.80.8-0.8-0.60.80.2-0.4
Number of responses in last shaping day1.31.33.5-0.61.2-1.0-1.0-1.01.0-1.0-1.11.0-1.51.9