Hub : Genes

Pcare

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Pcare 0.15 0.09 1.4e-08 0.12 0.14 0.14 0.13 4.0e-07 1.1e-07 9.4e-08 1.7e-07
2 pVTA gene expression Pcare 0.18 0.11 5.8e-10 0.23 0.24 0.23 0.23 1.6e-10 1.2e-10 1.6e-10 1.8e-10
3 IL gene expression Pcare 0.2 0.17 5.3e-03 0.05 0.02 0.02 0.03 2.8e-02 1.2e-01 9.0e-02 6.8e-02
4 PL gene expression Pcare 0.11 0.07 1.1e-16 0.14 0.15 0.14 0.14 7.7e-15 9.3e-16 4.4e-15 2.1e-15
5 OFC gene expression Pcare 0.2 0.15 7.2e-04 0.1 0.09 0.08 0.08 2.8e-03 4.7e-03 6.1e-03 5.1e-03
6 Brain gene expression Pcare 0.33 0.13 0.0e+00 0.39 0.4 0.4 0.4 6.9e-38 1.2e-39 1.1e-39 6.4e-40
7 Liver gene expression Pcare 0.05 0.04 7.4e-05 0.03 0.03 0.02 0.03 3.1e-04 4.1e-04 1.2e-03 8.3e-04
8 Adipose gene expression Pcare 0.12 0.09 1.7e-08 0.05 0.05 0.05 0.04 4.2e-06 2.7e-06 3.6e-06 9.3e-06
9 LHb gene expression Pcare 0.45 0.27 3.6e-07 0.22 0.23 0.24 0.25 4.5e-06 3.0e-06 1.8e-06 1.1e-06
10 NAcc gene expression Pcare 0.29 0.2 9.9e-08 0.06 0.07 0.06 0.06 4.4e-07 4.6e-08 2.3e-07 4.5e-07
11 RMTg gene expression Pcare 0.12 0.11 4.7e-03 0.07 0.07 0.08 0.07 6.1e-03 4.7e-03 4.2e-03 5.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density5.08.410.1-3.23.0-3.03.0-3.13.0-2.82.93.12.5-2.1
Area under the delay curve1.41.52.9-1.41.2-1.11.2-1.21.1-1.21.11.10.8-1.7
BMI with tail0.31.13.11.1-1.01.2-1.00.8-0.81.1-0.9-0.8-0.41.8
BMI without tail0.20.31.10.3-0.51.0-0.5-0.1-0.40.7-0.5-0.3-0.41.1
Body weight1.56.47.52.6-2.72.7-2.72.6-2.62.6-2.7-2.7-2.50.9
Weight adjusted by age0.20.20.30.3-0.40.4-0.50.2-0.30.5-0.5-0.5-0.6-0.5
Bone surface2.13.77.6-2.02.0-2.11.9-1.81.8-1.91.81.71.2-2.8
Bone volume2.64.36.9-2.22.1-2.12.1-2.12.0-2.01.92.01.4-2.6
Breakpoint value in progressive ratio session0.60.71.0-0.90.9-0.90.9-1.00.9-0.70.80.90.5-0.6
Number of licking bursts0.50.63.5-0.70.5-0.60.5-0.70.4-0.50.40.40.3-1.9
Context. condit. distance diff. score0.10.20.50.6-0.40.1-0.30.7-0.50.2-0.3-0.5-0.2-0.0
Locomotion velocity, session 10.10.10.70.1-0.30.5-0.30.3-0.20.3-0.4-0.2-0.3-0.8
Locomotion distance, session 11.92.52.8-1.61.7-1.61.7-1.71.6-1.61.61.71.5-0.8
Locomotion velocity, session 20.20.30.80.3-0.40.4-0.40.6-0.50.3-0.5-0.4-0.9-0.5
Locomotion distance, session 20.00.00.2-0.20.00.10.0-0.20.00.1-0.10.1-0.3-0.5
Locomotion velocity, session 30.40.40.9-0.60.7-0.70.6-0.70.5-0.80.60.60.21.0
Locomotion distance, session 30.90.91.6-1.21.1-0.91.0-1.31.0-0.91.01.00.5-0.3
Stereotopy head waving bouts, day 31.01.21.8-1.11.1-1.31.1-0.91.0-1.41.10.90.8-1.1
Stereotopy head waving duration, day 30.00.00.2-0.00.1-0.20.10.00.0-0.30.10.00.00.4
Locomotion velocity, session 70.50.50.7-0.80.8-0.80.8-0.80.8-0.80.80.70.3-0.0
Locomotion distance, session 70.00.10.20.2-0.20.1-0.20.3-0.30.1-0.2-0.3-0.40.1
Stereotopy head waving bouts, day 70.00.10.4-0.10.10.10.0-0.30.20.00.10.0-0.00.7
Stereotopy head waving duration, day 70.50.61.2-0.90.8-0.60.8-1.10.9-0.70.80.80.50.5
Locomotion velocity, session 80.00.00.2-0.1-0.00.0-0.00.1-0.10.0-0.1-0.1-0.40.1
Locomotion distance, session 80.10.20.5-0.20.4-0.60.4-0.10.3-0.50.50.20.2-0.7
Degree of sensitization distance1.21.21.81.3-1.21.0-1.21.4-1.11.0-1.1-1.2-0.70.7
Degree of sensitization stereotypy0.10.10.90.0-0.00.3-0.1-0.30.10.2-0.0-0.0-0.20.9
Conditioned locomotion2.73.24.5-1.51.9-2.11.9-1.51.8-2.12.01.72.0-0.4
Cocaine response after cond. corrected2.52.84.4-1.91.6-1.31.6-1.81.6-1.51.51.61.6-2.1
Cocaine response after cond. not corrected3.43.74.4-2.02.0-1.82.0-2.01.9-2.02.01.92.1-1.4
Cocaine response before conditioning0.70.81.4-0.50.9-1.00.9-0.60.9-1.01.10.90.91.2
Saline control response0.81.01.8-1.41.1-0.81.0-1.21.2-0.80.91.20.4-0.9
Bone: connectivity density5.18.09.6-3.12.9-2.92.9-3.12.8-2.72.82.92.4-2.6
Bone: cortical apparent density0.60.82.2-1.00.8-0.90.8-0.90.7-0.70.70.70.9-1.5
Bone: cortical area0.40.61.1-0.70.7-0.70.7-0.70.9-0.70.80.70.8-1.1
Bone: cortical porosity1.11.21.4-1.11.1-1.11.1-1.11.2-1.01.11.11.1-0.9
Bone: cortical porosity1.01.11.3-1.11.0-1.01.0-1.11.1-0.91.01.10.9-1.1
Bone: cortical thickness0.00.00.20.1-0.00.1-0.0-0.00.20.20.10.10.5-0.1
Bone: cortical thickness1.41.72.7-1.11.3-1.41.3-1.11.3-1.41.41.31.7-0.9
Bone: cortical tissue density0.50.62.1-0.80.7-0.70.7-0.80.6-0.60.60.60.7-1.5
Condit. Reinf. active minus inactive responses0.30.30.60.4-0.60.7-0.60.5-0.40.6-0.7-0.4-0.8-0.4
Condit. Reinf. active-inactive response ratio0.30.31.00.3-0.50.7-0.50.4-0.30.6-0.6-0.4-1.00.2
Condit. Reinf. active responses0.50.71.9-0.90.8-0.60.7-0.70.9-0.80.60.80.5-1.4
Condit. Reinf. inactive responses1.82.22.9-1.41.4-1.51.5-1.21.4-1.51.41.41.7-1.7
Incentive salience index mean0.20.31.0-0.70.4-0.30.4-0.50.6-0.40.30.5-0.2-1.0
Condit. Reinf. lever presses1.11.52.2-1.51.3-1.11.2-1.31.5-1.11.11.40.4-1.1
Condit. Reinf. active minus inactive responses3.54.46.8-1.92.1-2.22.2-1.82.0-2.32.22.02.6-1.4
Condit. Reinf. active-inactive response ratio0.70.81.2-0.70.9-1.10.9-0.70.7-1.11.00.71.1-0.7
Condit. Reinf. active responses2.83.96.9-1.72.0-2.12.0-1.71.9-2.22.21.92.6-0.9
Condit. Reinf. inactive responses1.82.23.9-1.31.5-1.51.5-1.41.6-1.61.61.52.0-0.2
Condit. Reinf. lever presses1.82.43.7-1.31.5-1.71.6-1.31.5-1.71.71.41.9-1.1
Condit. Reinf. lever reinforcers received2.53.56.3-1.61.8-1.91.9-1.71.8-2.02.01.72.5-1.3
Conditioned reinforcement - actives0.50.52.6-0.70.5-0.40.5-0.80.4-0.50.40.30.2-1.6
Conditioned reinforcement - inactives1.71.92.8-1.71.4-1.51.4-1.71.4-1.31.31.20.8-1.4
Conditioned locomotion0.40.43.60.0-0.30.5-0.3-0.0-0.30.3-0.5-0.4-0.6-1.9
Patch foraging indifference point 0 sec0.20.41.20.4-0.50.7-0.60.5-0.50.6-0.7-0.6-1.10.1
Patch foraging indifference point AUC1.51.72.6-1.51.2-1.41.3-1.61.3-0.91.21.31.2-1.2
Delay disc. indifference point, 0s delay0.40.40.90.7-0.60.8-0.60.7-0.50.5-0.6-0.5-0.10.9
Delay disc. indifference point, 16s delay1.41.52.1-1.41.3-1.21.3-1.41.2-1.21.21.30.8-0.9
Delay disc. indifference point, 2s delay0.00.00.1-0.0-0.10.2-0.10.1-0.00.1-0.10.1-0.1-0.0
Delay disc. indifference point, 24s delay5.35.17.0-2.42.4-2.22.3-2.22.1-2.42.22.01.8-2.7
Delay disc. indifference point, 4s delay0.20.20.4-0.60.4-0.40.4-0.60.3-0.40.40.30.2-0.2
Delay disc. indifference point, 8s delay1.31.43.3-1.31.2-1.11.1-1.11.1-1.11.01.10.7-1.8
Indifference point function ln k0.10.21.20.4-0.10.2-0.10.4-0.3-0.2-0.0-0.2-0.01.1
Indifference point function log k0.10.21.20.4-0.10.2-0.10.4-0.3-0.2-0.0-0.2-0.01.1
Patch foraging total patch changes 0 sec0.10.20.70.3-0.40.5-0.40.4-0.40.5-0.5-0.5-0.90.1
Patch foraging total patch changes 12 sec0.60.81.20.9-1.00.8-0.90.9-0.81.1-0.9-0.9-0.80.4
Patch foraging total patch changes 18 sec0.10.10.4-0.2-0.10.3-0.1-0.30.10.4-0.20.0-0.3-0.6
Patch foraging total patch changes 24 sec1.31.62.01.2-1.31.2-1.31.3-1.31.3-1.3-1.4-1.4-0.5
Patch foraging total patch changes 6 sec0.00.10.2-0.1-0.10.2-0.1-0.00.10.5-0.2-0.1-0.3-0.4
Patch foraging time to switch 0 sec0.10.20.3-0.40.4-0.40.4-0.40.5-0.50.50.40.50.3
Patch foraging water rate 0 sec0.10.20.90.2-0.30.4-0.30.1-0.30.3-0.3-0.3-0.2-1.0
Patch foraging water rate 12 sec1.62.43.81.9-1.61.6-1.61.9-1.81.3-1.4-1.9-1.00.7
Patch foraging water rate 18 sec0.30.40.90.8-0.70.8-0.71.0-0.70.4-0.6-0.8-0.2-0.4
Patch foraging water rate 24 sec1.82.53.31.7-1.71.8-1.71.6-1.61.7-1.6-1.5-1.01.3
Patch foraging water rate 6 sec1.21.82.51.6-1.41.6-1.41.4-1.51.2-1.3-1.5-1.00.5
Seeking ratio, delayed vs. immediate footshock0.40.51.40.7-0.60.6-0.60.7-0.60.8-0.6-0.5-0.61.2
Distance traveled before self-admin0.30.32.6-0.30.3-0.30.2-0.10.0-0.50.2-0.10.1-1.6
Distance traveled after self-admin0.30.30.90.1-0.50.7-0.50.1-0.50.5-0.6-0.5-0.5-0.9
Extensor digitorum longus weight4.517.720.8-4.54.5-4.34.4-4.44.6-4.24.44.54.0-1.8
Bone: elastic displacement0.91.02.3-0.71.0-1.01.0-0.61.1-0.91.11.21.5-0.1
Bone: elastic work1.11.41.9-1.01.2-1.31.2-1.01.3-1.11.31.41.4-0.1
Bone: endosteal estimation0.20.40.9-0.40.6-0.90.6-0.10.5-0.80.60.3-0.0-1.0
Bone: endosteal perimeter0.10.32.0-0.30.4-0.60.4-0.20.3-0.40.30.1-0.2-1.4
Epididymis fat weight13.932.436.56.0-6.05.9-6.05.9-6.05.8-6.0-6.0-5.62.2
Delta time in closed arm before/after self-admin0.10.10.10.3-0.20.1-0.20.3-0.30.2-0.2-0.3-0.30.4
Delta time in open arm before/after self-admin0.90.91.8-1.10.8-0.60.9-1.31.1-0.40.81.30.90.8
Diff in mean of infusions in LGA sessions0.20.20.5-0.70.4-0.10.4-0.70.5-0.20.30.60.4-0.3
Delay discount exponential model param2.12.23.51.7-1.51.4-1.51.5-1.41.5-1.4-1.4-1.01.9
Extinction: sum of active levers before priming1.01.02.7-1.01.0-0.91.0-0.91.0-0.90.91.00.8-1.6
Active lever presses in extinction session 60.00.00.30.0-0.1-0.2-0.00.2-0.10.1-0.1-0.1-0.1-0.5
Bone: final force0.10.20.9-0.40.4-0.40.4-0.20.5-0.30.30.40.1-0.9
Bone: final moment0.10.20.5-0.40.4-0.50.4-0.20.5-0.30.40.40.1-0.7
Food consumed during 24 hour testing period0.20.30.5-0.40.4-0.50.5-0.40.6-0.50.50.50.7-0.7
Glucose0.50.71.10.8-0.90.7-0.90.9-1.00.8-0.9-1.0-1.00.3
Heart weight9.313.115.63.8-3.83.9-3.83.9-3.73.7-3.8-3.9-3.51.0
Delay discount hyperbolic model param1.81.92.81.6-1.41.3-1.41.4-1.31.4-1.3-1.3-1.01.7
Intermittent access intake day 1-15 change0.10.10.20.4-0.10.1-0.10.5-0.2-0.10.0-0.40.5-0.4
Intermittent access intake escalation0.20.20.60.7-0.40.3-0.40.7-0.50.2-0.3-0.70.2-0.4
Intermittent access intake escalation 20.70.71.21.1-0.90.8-0.91.1-0.90.7-0.8-1.1-0.4-0.5
Intermitt. access day 1 inactive lever presses0.30.32.4-0.2-0.1-0.0-0.1-0.1-0.20.2-0.3-0.2-0.8-1.6
Intermitt. access day 15 inactive lever presses3.84.25.1-2.32.1-2.12.1-2.02.2-1.92.02.01.4-2.2
Intermitt. access escalation Index0.80.72.80.4-0.70.8-0.70.2-0.61.2-0.8-0.4-0.81.7
Intermittent access day 1 total infusions4.04.67.0-2.62.3-2.32.2-2.62.2-2.02.12.31.6-1.2
Intermittent access day 15 total infusions1.41.52.1-1.41.3-1.21.3-1.31.1-1.21.21.11.0-1.4
Intermittent access terminal intake (last 3 days)1.41.52.4-1.51.2-1.11.2-1.41.1-1.11.11.10.9-1.6
Intermittent access total infusions1.61.82.7-1.61.4-1.31.3-1.61.2-1.31.21.20.9-1.6
Intermittent access day 1 locomotion2.32.43.4-1.71.6-1.61.6-1.81.7-1.41.51.71.3-0.8
Intermittent access day 15 total locomotion0.60.73.4-0.80.7-0.70.6-0.90.5-0.70.50.40.4-1.8
Intermittent access total locomotion0.50.63.9-0.70.5-0.50.4-0.90.4-0.30.30.30.1-2.0
Intermittent access standard deviation0.10.10.50.2-0.1-0.1-0.10.4-0.10.1-0.1-0.2-0.2-0.7
Left kidney weight0.10.21.4-0.20.3-0.10.30.20.2-0.60.3-0.00.4-1.2
Right kidney weight0.61.63.41.4-1.21.2-1.21.8-1.30.9-1.2-1.5-1.1-0.7
Cocaine induced anxiety0.10.10.6-0.20.2-0.20.2-0.20.2-0.10.20.30.10.8
Post-drug Anxiety0.60.71.40.7-0.80.8-0.80.6-0.80.9-0.9-0.8-1.20.9
Baseline Anxiety0.40.40.60.5-0.70.6-0.70.6-0.70.6-0.8-0.8-0.8-0.4
Tail length0.20.61.20.6-0.70.8-0.80.6-0.80.7-0.8-1.0-1.1-0.2
Length with tail1.45.37.52.1-2.32.2-2.42.4-2.42.2-2.4-2.6-2.7-0.9
Length without tail0.92.13.31.4-1.40.9-1.41.8-1.41.2-1.4-1.6-1.8-1.1
Times rat made contact with spout2.52.94.2-2.01.8-1.81.7-1.71.7-1.71.61.70.8-2.0
Lifetime Intake1.82.03.0-1.71.5-1.61.4-1.71.4-1.31.31.30.9-1.4
Liver weight, left1.93.14.22.0-1.81.4-1.82.0-1.91.5-1.8-2.0-1.80.9
Liver weight, right9.015.017.24.0-4.13.9-4.14.1-4.13.9-4.1-4.1-4.01.1
Locomotor activity0.10.21.6-0.50.2-0.10.2-0.30.30.00.10.3-0.1-1.3
Locomotor testing distance1.01.66.8-1.41.1-0.81.0-1.11.2-0.90.91.10.7-2.6
Locomotor testing rearing0.81.33.1-1.21.0-0.91.0-1.31.1-0.70.91.21.0-1.8
Locomotion in novel chamber1.31.63.41.4-1.31.0-1.31.2-1.11.3-1.2-1.0-1.01.9
Locomotion in novel chamber post-restriction1.61.92.31.3-1.41.5-1.51.3-1.51.4-1.5-1.4-1.5-0.0
Fecal boli incidents, locomotor time 10.60.70.9-0.90.8-0.90.9-0.90.9-0.90.81.00.80.3
Change in fecal boli incidents, locomotor task3.73.54.42.0-2.12.0-2.01.9-2.02.1-2.0-2.0-1.50.6
Time >=10cm from walls, locomotor time 10.40.43.3-0.30.2-0.50.3-0.20.2-0.30.30.10.8-1.8
Bouts of movement, locomotor time 13.84.15.8-2.12.2-2.12.2-2.12.1-2.42.22.01.8-0.3
Total resting periods, locomotor time 13.74.05.7-2.02.2-2.12.2-2.02.1-2.42.22.01.9-0.3
Rest time, locomotor task time 10.10.11.1-0.20.1-0.20.1-0.00.1-0.20.10.0-0.2-1.1
Distance moved, locomotor task time 10.80.81.50.8-0.91.1-0.90.6-0.81.1-0.9-0.7-0.71.2
Vertical activity count, locomotor time 10.40.40.60.8-0.60.6-0.60.7-0.70.5-0.6-0.7-0.40.6
Time >=10cm from walls, locomotor time 20.50.65.7-0.1-0.0-0.30.00.1-0.1-0.0-0.0-0.20.5-2.4
Bouts of movement, locomotor time 20.10.10.30.4-0.2-0.1-0.20.6-0.4-0.0-0.2-0.6-0.0-0.3
Total resting periods, locomotor time 20.10.10.30.2-0.1-0.2-0.00.3-0.2-0.2-0.0-0.30.2-0.6
Rest time, locomotor task time 22.02.33.3-1.61.4-1.41.5-1.61.5-1.51.41.51.4-1.8
Distance moved, locomotor task time 21.11.21.71.1-1.11.2-1.11.0-1.11.3-1.1-0.9-0.81.3
Vertical activity count, locomotor time 21.31.42.41.5-1.21.0-1.21.5-1.31.0-1.0-1.4-0.91.0
Light reinforcement 13.86.88.4-2.82.8-2.92.8-2.82.9-2.52.82.82.4-0.6
Light reinforcement 22.73.65.5-2.12.1-2.32.1-1.82.1-1.92.02.01.5-0.4
Bone: marrow area0.20.40.9-0.40.7-0.90.7-0.10.5-0.90.70.40.0-0.9
Bone: maximum diameter1.01.83.2-1.31.4-1.41.3-1.21.4-1.31.31.21.0-1.8
Bone: maximum force0.00.00.1-0.00.1-0.10.10.10.20.00.10.20.0-0.3
Bone: maximum moment0.00.00.1-0.00.1-0.30.10.10.2-0.10.20.20.1-0.1
Mean time between licks in bursts2.43.44.42.1-1.91.8-1.91.9-1.91.7-1.8-1.9-1.61.9
Mean num. licks in bursts0.10.10.2-0.30.4-0.30.4-0.30.4-0.30.40.40.10.4
Cd content in liver0.20.21.5-0.30.2-0.20.3-0.20.3-0.20.20.30.5-1.2
Co content in liver6.88.09.6-2.93.0-2.73.0-2.83.0-2.83.03.12.9-1.5
Cu content in liver0.40.54.0-0.90.5-0.20.4-0.40.4-0.30.20.5-0.3-2.0
Fe content in liver0.80.99.0-0.1-0.20.3-0.30.4-0.30.3-0.5-0.4-0.6-3.0
K content in liver0.50.51.90.6-0.50.3-0.61.0-0.70.3-0.6-0.8-1.40.2
Mg content in liver0.60.63.30.4-0.50.5-0.60.9-0.70.4-0.7-0.7-1.8-0.4
Mn content in liver0.30.30.6-0.20.5-0.60.5-0.10.5-0.70.70.50.70.8
Na content in liver0.30.31.6-0.40.4-0.50.4-0.10.3-0.50.30.2-0.5-1.3
Rb content in liver0.10.10.7-0.0-0.00.1-0.10.1-0.20.0-0.2-0.2-0.80.3
Se content in liver0.50.61.10.6-0.80.9-0.80.9-0.80.9-0.9-0.8-1.10.1
Sr content in liver0.10.10.30.5-0.30.1-0.30.4-0.50.1-0.2-0.4-0.20.6
Zn content in liver0.50.51.50.3-0.71.2-0.70.3-0.41.1-0.9-0.3-1.00.2
Bone: minimum diameter0.10.31.00.3-0.30.4-0.40.5-0.30.4-0.5-0.5-1.0-0.7
Time in familiar zone, hab. session 10.80.71.20.7-0.80.9-0.90.9-0.81.0-0.9-0.8-1.10.6
Time in novel zone, hab. session 10.60.60.80.8-0.80.9-0.80.6-0.70.8-0.7-0.6-0.30.9
Total zone transitions, hab. session 10.10.10.3-0.30.4-0.30.4-0.30.4-0.40.40.40.6-0.3
Total locomotion distance, hab. session 10.10.10.3-0.00.2-0.30.2-0.10.2-0.40.30.20.50.4
Locomotion velocity, hab. session 10.81.11.8-0.91.1-1.11.1-1.01.0-1.31.21.01.3-0.3
Time in familiar zone, hab. session 20.10.10.3-0.10.00.2-0.00.10.00.2-0.10.0-0.50.4
Time in novel zone, hab. session 20.30.30.40.7-0.60.4-0.60.5-0.70.5-0.6-0.6-0.1-0.1
Total zone transitions, hab. session 20.10.10.2-0.30.4-0.40.4-0.20.4-0.50.50.40.10.1
Total locomotion distance, hab. session 20.10.20.5-0.30.5-0.50.5-0.30.4-0.70.50.40.40.3
Locomotion velocity, hab. session 20.40.50.9-0.60.7-0.80.7-0.70.7-0.90.80.70.60.5
Novel to familiar place preference ratio0.40.40.90.9-0.80.6-0.70.6-0.60.7-0.5-0.60.30.7
Novelty place preference0.80.81.41.2-1.00.9-1.00.9-0.91.0-0.8-0.9-0.10.7
Time in novel zone, NPP test1.01.11.71.3-1.21.0-1.11.1-1.01.2-1.0-1.0-0.30.8
Total zone transitions, NPP test1.31.82.2-1.41.5-1.41.5-1.41.4-1.41.51.41.1-0.9
Total locomotion distance, NPP test1.52.12.8-1.31.5-1.51.5-1.41.4-1.71.61.41.6-0.7
Locomotion velocity, NPP test3.04.25.2-2.02.2-2.12.2-2.12.1-2.32.22.12.1-0.8
Intraocular pressure3.14.35.41.9-2.12.3-2.12.3-2.12.1-2.2-2.1-2.2-1.0
Delta distance traveled before/after self-admin1.41.52.31.1-1.31.4-1.30.9-1.11.5-1.4-1.0-1.11.0
Delta ambulatory time before/after self-admin0.20.30.70.4-0.60.6-0.60.2-0.40.8-0.6-0.4-0.50.3
Parametrial fat weight5.210.012.63.3-3.33.3-3.32.8-3.13.5-3.2-2.8-2.73.4
Pavlov. Cond. lever latency1.72.14.41.7-1.51.5-1.41.4-1.41.4-1.3-1.3-0.42.1
Pavlov. Cond. magazine entry latency0.00.10.4-0.20.1-0.10.10.00.0-0.10.00.0-0.6-0.4
Pavlov. Cond. change in total contacts0.30.32.4-0.30.2-0.20.1-0.10.0-0.20.0-0.1-0.8-1.5
Pavlov. Cond. index score0.60.82.2-1.00.9-0.90.9-0.80.8-0.90.80.7-0.0-1.5
Pavlov. Cond. latency score0.60.82.7-1.00.9-0.90.8-0.80.8-0.90.70.6-0.1-1.6
Pavlov. Cond. lever contacts1.01.21.6-1.31.2-1.21.1-1.11.1-1.11.01.00.2-1.3
Pavlov. Cond. magazine entry number0.20.30.50.5-0.60.6-0.60.4-0.50.7-0.5-0.5-0.00.2
Pavlov. Cond. intertrial magazine entries1.62.02.6-1.51.4-1.41.4-1.61.4-1.31.31.41.5-1.2
Pavlov. Cond. lever-magazine prob. diff.1.51.83.0-1.51.4-1.41.4-1.31.3-1.41.31.20.5-1.7
Pavlov. Cond. response bias1.11.31.7-1.21.3-1.31.2-1.01.2-1.31.21.10.5-0.8
Pavlov. Cond. lever latency1.52.02.41.4-1.41.5-1.51.5-1.41.5-1.5-1.4-1.40.8
Pavlov. Cond. magazine entry latency0.10.20.3-0.40.4-0.30.4-0.50.4-0.40.40.50.4-0.0
Pavlov. Cond. change in total contacts0.70.93.3-0.80.8-1.00.8-0.70.7-1.00.80.60.9-1.8
Pavlov. Cond. index score0.70.91.2-0.90.9-1.11.0-0.90.9-1.11.00.81.1-0.8
Pavlov. Cond. latency score0.60.81.1-0.80.9-1.00.9-0.80.8-1.00.90.81.0-0.9
Pavlov. Cond. lever contacts0.71.01.4-0.91.0-1.11.0-0.90.9-1.21.10.91.1-0.8
Pavlov. Cond. magazine entry number0.00.10.10.3-0.20.2-0.20.3-0.30.3-0.2-0.3-0.30.1
Pavlov. Cond. intertrial magazine entries2.43.23.91.9-1.92.0-1.81.7-1.81.9-1.8-1.7-1.41.7
Pavlov. Cond. lever-magazine prob. diff.0.40.50.8-0.60.7-0.90.7-0.70.6-0.90.80.60.9-0.7
Pavlov. Cond. response bias1.41.92.5-1.31.4-1.61.4-1.41.4-1.61.51.31.5-0.6
Time in closed arm before self-admin0.40.51.20.7-0.71.1-0.70.7-0.60.7-0.7-0.6-0.10.3
Time in closed arm after self-admin1.21.22.01.1-1.21.4-1.21.1-1.01.1-1.2-1.0-0.80.7
Time in open arm before self-admin0.10.10.4-0.10.4-0.60.3-0.10.1-0.60.40.1-0.0-0.0
Time in open arm after self-admin2.42.63.8-1.81.7-1.91.7-1.81.7-1.41.71.81.2-0.4
Bone: periosteal estimation0.40.92.1-0.81.0-1.11.0-0.61.0-1.01.00.80.5-1.4
Bone: periosteal perimeter0.20.31.0-0.40.5-0.70.5-0.40.5-0.50.50.40.3-1.0
Bone: post-yield work0.30.50.6-0.80.7-0.80.7-0.60.7-0.70.70.80.5-0.2
Progressive ratio test 1 active lever presses0.40.41.2-0.80.6-0.70.6-0.80.5-0.50.50.50.2-1.1
Progressive ratio test 1 breakpoint0.40.41.9-0.80.6-0.70.5-0.70.5-0.50.40.40.1-1.4
Progressive ratio test 1 inactive lever presses1.11.24.0-1.31.0-1.21.0-1.21.0-0.70.80.90.4-2.0
Progressive ratio test 2 active lever presses0.20.21.6-0.20.00.1-0.1-0.2-0.3-0.2-0.2-0.3-0.3-1.3
Progressive ratio test 2 breakpoint0.20.21.5-0.30.10.10.0-0.3-0.2-0.3-0.1-0.3-0.3-1.2
Progressive ratio test 2 inactive lever presses0.80.93.2-1.10.8-0.90.8-1.00.7-0.80.60.60.3-1.8
Incentive Sensitization - Responses0.10.10.20.2-0.20.4-0.20.2-0.4-0.1-0.2-0.40.10.2
Incentive Sensitization - Breakpoint0.20.20.40.3-0.40.6-0.40.4-0.60.1-0.4-0.6-0.1-0.0
Sum of active levers in priming session hrs 5-61.11.11.3-1.11.1-1.11.1-1.11.1-1.01.11.00.8-0.9
Progressive ratio0.60.70.90.9-0.90.6-0.91.0-0.90.9-0.8-0.9-0.70.1
Food seeking constrained by brief footshock2.53.13.7-1.91.8-1.71.8-1.81.8-1.71.71.71.7-1.8
Seeking ratio, punishment vs. effort1.72.12.4-1.51.5-1.31.5-1.51.5-1.51.41.41.4-1.2
Retroperitoneal fat weight19.965.374.18.4-8.68.4-8.68.0-8.48.6-8.5-8.4-7.74.5
Reaction time number correct0.91.34.7-0.91.0-0.81.0-0.90.9-1.11.00.81.4-2.2
Reaction time mean minus median0.10.10.2-0.40.2-0.00.2-0.40.4-0.10.20.30.2-0.1
Reaction time mean minus median AUC0.00.00.1-0.10.00.10.0-0.20.20.00.00.20.20.1
Reaction time num false alarms0.30.30.5-0.70.7-0.70.7-0.40.6-0.60.70.60.40.1
Reaction time num false alarms AUC0.50.71.0-1.01.0-0.91.0-0.70.9-0.90.90.80.7-0.2
Reaction time trials correct on left0.91.34.7-0.91.0-0.81.0-0.90.9-1.11.00.81.4-2.2
Reaction time trials on left1.01.44.6-1.01.0-0.81.0-1.00.9-1.21.00.81.4-2.2
Reaction time mean0.60.81.70.3-0.91.3-0.90.5-0.71.1-1.1-0.6-1.2-0.5
Reaction time mean AUC0.50.61.40.2-0.81.2-0.80.3-0.61.0-1.0-0.5-1.1-0.6
Median of all reaction times0.70.91.80.3-0.91.3-1.00.5-0.81.2-1.2-0.7-1.3-0.7
Reaction time omissions0.20.31.5-0.40.4-0.20.4-0.30.5-0.30.40.70.41.2
Reaction time false alarm rate0.10.10.7-0.30.3-0.30.3-0.00.2-0.10.20.2-0.20.8
Reaction time premature initiation rate0.20.30.60.5-0.40.2-0.50.6-0.50.4-0.4-0.5-0.70.8
Reaction time premature initiations0.00.00.1-0.00.1-0.30.10.10.0-0.30.2-0.00.1-0.2
Std. dev. reaction times0.20.20.60.3-0.50.8-0.50.3-0.30.6-0.6-0.3-0.50.0
Reaction time trials completed1.01.44.6-1.01.0-0.81.0-1.00.9-1.21.00.81.4-2.2
Reaction time trials AUC1.21.85.7-1.21.2-1.01.1-1.21.1-1.31.11.01.5-2.4
Run reversals in cocaine runway, females0.00.00.10.10.0-0.30.00.1-0.0-0.30.1-0.20.3-0.0
Run reversals in cocaine runway, males0.60.60.7-0.60.8-0.60.8-0.70.8-0.70.80.70.9-0.8
Latency to leave start box in cocaine runway0.30.40.6-0.70.6-0.40.6-0.80.6-0.50.60.70.60.4
Latency to leave start box in cocaine runway, F0.40.50.7-0.90.8-0.70.7-0.90.7-0.50.60.80.50.2
Latency to leave start box in cocaine runway, M0.10.10.3-0.20.2-0.30.2-0.20.2-0.40.30.10.5-0.4
Std. dev. time between licks in bursts0.10.10.60.0-0.20.3-0.2-0.1-0.10.3-0.3-0.1-0.2-0.7
Total sessions with >9 infusions0.50.61.0-0.80.8-1.00.8-0.90.8-0.50.70.80.5-0.3
Short access day 1 total inactive lever presses2.83.14.6-2.11.8-1.91.8-1.91.9-1.31.61.91.1-1.9
Short access day 10 total inactive lever presses0.50.52.9-0.60.6-0.80.6-0.50.4-0.50.50.30.2-1.7
Short access day 1 total infusions1.51.63.0-1.61.3-1.51.3-1.71.4-0.71.11.40.7-0.9
Short access day 10 total infusions3.03.34.8-2.11.9-1.91.9-2.21.9-1.81.71.91.4-1.2
Short access total infusions1.01.22.0-1.31.1-1.41.1-1.41.2-0.81.01.10.5-0.7
Short access day 1 locomotion3.94.25.0-2.22.1-2.12.1-2.22.2-1.92.12.21.7-1.8
Short access day 10 total locomotion1.01.12.1-1.21.1-0.91.0-1.41.1-0.81.01.10.7-1.1
Short access total locomotion0.30.30.8-0.70.5-0.50.5-0.90.6-0.20.40.70.1-0.8
One hour access (0.3 mA shock)1.21.32.7-1.31.2-1.31.1-1.40.9-1.21.00.80.5-1.6
Compulsive drug intake0.30.30.80.7-0.50.0-0.50.6-0.60.5-0.4-0.6-0.40.9
One hour access (shock baseline)1.31.52.8-1.51.3-1.11.2-1.51.1-1.21.01.00.7-1.7
Social response proportion0.30.30.70.5-0.60.8-0.60.3-0.50.8-0.6-0.5-0.60.3
Social responses0.10.10.3-0.1-0.20.6-0.2-0.20.10.4-0.2-0.0-0.1-0.4
Social time0.60.81.70.7-0.91.3-0.90.7-0.71.2-0.9-0.7-0.90.5
Soleus weight5.114.917.5-4.14.1-3.94.1-4.04.2-3.84.04.23.5-1.7
Bone: stiffness0.10.10.90.2-0.20.1-0.30.2-0.30.2-0.3-0.4-0.4-0.9
Tibialis anterior weight3.913.216.1-3.83.8-3.73.8-3.94.0-3.53.84.03.5-0.9
Time to tail flick, vehicle, before self-admin1.61.62.61.2-1.31.6-1.31.3-1.21.3-1.3-1.2-0.91.3
Time to tail flick, vehicle, after self-admin3.13.35.01.7-1.82.2-1.91.9-1.81.9-1.9-1.8-1.80.9
Time to tail flick, test, before self-admin0.50.51.0-0.80.7-0.70.7-0.70.8-0.70.71.00.60.2
Time to tail flick, test, after self-admin0.10.10.20.3-0.20.2-0.30.4-0.30.0-0.3-0.4-0.3-0.3
Delta time to tail flick, vehicle, before/after SA0.10.10.30.3-0.20.2-0.20.5-0.40.1-0.2-0.4-0.5-0.5
Delta time to tail flick, test, before/after SA0.30.30.9-0.40.5-0.60.5-0.30.4-0.80.50.10.4-1.0
Tibia length2.67.38.92.5-2.82.7-2.82.9-2.82.9-3.0-2.8-3.0-0.8
Ambulatory time before self-admin0.40.52.3-0.50.6-0.60.5-0.40.4-0.80.50.30.4-1.5
Ambulatory time after self-admin0.20.20.90.1-0.40.6-0.4-0.1-0.30.5-0.5-0.3-0.3-0.9
Bone: tissue strength0.40.41.40.4-0.60.6-0.60.3-0.50.8-0.6-0.4-0.61.2
Total heroin consumption2.32.73.2-1.71.8-1.81.8-1.61.7-1.61.81.71.5-0.7
Bone: trabecular number4.26.58.4-2.92.7-2.52.6-2.92.6-2.42.52.72.1-2.0
Bone: trabecular spacing2.02.53.21.6-1.61.8-1.61.6-1.41.7-1.6-1.5-1.71.3
Bone: trabecular thickness0.50.71.0-0.70.8-0.80.8-1.00.8-0.80.90.90.80.5
Bone: trabecular tissue density0.10.10.4-0.30.3-0.30.3-0.40.2-0.40.20.00.2-0.6
Water consumed over 24 hours1.21.42.1-1.21.2-1.51.2-1.01.1-1.31.21.10.8-1.4
Number of responses in last shaping day0.30.33.5-0.20.2-0.20.10.10.0-0.30.0-0.1-0.2-1.9