Hub : Genes

Pcare

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Pcare 0.12 0.08 5.1e-07 0.1 0.11 0.1 0.1 8.0e-06 2.1e-06 6.4e-06 7.4e-06
2 Liver gene expression Pcare 0.04 0.04 3.0e-04 0.02 0.02 0.02 0.02 9.3e-04 1.3e-03 4.3e-03 2.0e-03
3 PL gene expression Pcare 0.1 0.06 4.4e-16 0.13 0.15 0.14 0.14 2.5e-14 1.0e-15 3.9e-15 3.1e-15
4 IL gene expression Pcare 0.19 0.16 6.9e-03 0.02 0.01 0.01 0.01 8.8e-02 2.2e-01 1.7e-01 1.7e-01
5 pVTA alternative TSS XM_006239771.5 0.06 0.05 5.5e-05 0.06 0.06 0.06 0.06 2.1e-05 2.0e-05 1.7e-05 1.7e-05
6 Adipose gene expression Pcare 0.09 0.07 1.7e-08 0.06 0.06 0.06 0.06 2.5e-07 1.7e-07 1.8e-07 3.4e-07
7 IC gene expression Pcare 0.28 0.17 6.6e-09 0.17 0.2 0.19 0.21 1.6e-07 8.2e-09 2.6e-08 3.7e-09
8 RMTg gene expression Pcare 0.12 0.13 7.4e-03 0.08 0.08 0.08 0.08 4.1e-03 4.6e-03 3.2e-03 4.1e-03
9 LHb gene expression Pcare 0.49 0.27 1.4e-07 0.18 0.23 0.22 0.22 3.7e-05 4.5e-06 6.2e-06 5.9e-06
10 pVTA gene expression Pcare 0.28 0.15 0.0e+00 0.31 0.33 0.33 0.33 1.9e-25 6.8e-27 3.1e-27 2.8e-27
11 OFC gene expression Pcare 0.25 0.18 1.5e-04 0.13 0.12 0.07 0.12 4.8e-04 6.9e-04 9.9e-03 8.0e-04
12 Brain gene expression Pcare 0.3 0.11 0.0e+00 0.42 0.41 0.42 0.42 1.5e-41 3.1e-41 9.0e-42 1.4e-41
13 NAcc gene expression Pcare 0.17 0.13 1.1e-07 0.04 0.05 0.04 0.04 7.3e-07 1.0e-07 1.9e-07 7.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density4.88.39.52.92.82.92.6-2.82.93.13.13.03.03.02.72.6
Area under the delay curve2.12.510.71.41.41.41.4-0.41.31.53.31.41.31.61.51.1
BMI with tail0.10.30.9-0.6-0.7-0.6-0.60.7-0.6-0.6-0.9-0.5-0.5-0.5-0.2-0.0
BMI without tail0.31.01.8-1.1-1.3-1.0-1.01.3-1.1-0.8-1.1-0.9-0.9-0.8-0.6-1.0
Body weight1.56.47.6-2.6-2.6-2.6-2.62.8-2.7-2.5-1.8-2.6-2.6-2.4-2.4-2.5
Weight adjusted by age0.10.10.2-0.3-0.2-0.3-0.20.3-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.4
Bone surface1.83.46.11.91.91.91.9-2.11.81.82.51.81.71.71.21.3
Bone volume2.34.16.62.12.02.11.9-2.22.02.12.62.02.02.01.51.5
Breakpoint value in progressive ratio session0.50.71.10.80.70.80.7-0.60.81.00.90.80.91.00.70.4
Number of licking bursts0.20.31.20.50.50.50.3-0.50.40.71.10.50.50.80.60.2
Context. condit. distance diff. score0.10.10.3-0.2-0.1-0.3-0.00.1-0.2-0.4-0.4-0.3-0.4-0.5-0.3-0.1
Locomotion velocity, session 10.10.10.3-0.3-0.4-0.3-0.40.4-0.3-0.40.1-0.2-0.3-0.3-0.6-0.5
Locomotion distance, session 11.92.32.81.61.61.61.6-1.51.61.41.71.61.61.41.11.4
Locomotion velocity, session 20.20.30.7-0.4-0.3-0.4-0.40.3-0.5-0.6-0.2-0.5-0.5-0.5-0.9-0.9
Locomotion distance, session 20.00.00.30.0-0.10.0-0.20.2-0.0-0.10.5-0.00.00.1-0.3-0.4
Locomotion velocity, session 30.30.40.70.70.80.70.7-0.70.70.6-0.20.50.70.70.30.2
Locomotion distance, session 30.80.91.41.00.91.00.8-0.81.01.10.70.91.11.20.80.4
Stereotopy head waving bouts, day 31.01.21.91.11.41.11.2-1.41.11.11.41.01.00.90.90.8
Stereotopy head waving duration, day 30.00.00.10.10.30.10.1-0.30.10.00.1-0.00.0-0.1-0.1-0.1
Locomotion velocity, session 70.50.60.80.90.90.90.9-0.80.90.90.10.70.90.80.60.2
Locomotion distance, session 70.10.10.3-0.2-0.1-0.2-0.20.2-0.2-0.3-0.3-0.3-0.3-0.2-0.4-0.5
Stereotopy head waving bouts, day 70.10.10.20.20.10.20.1-0.10.20.4-0.30.20.30.40.30.1
Stereotopy head waving duration, day 70.40.51.00.80.60.80.6-0.60.71.00.10.80.90.90.80.5
Locomotion velocity, session 80.00.00.2-0.1-0.1-0.1-0.2-0.1-0.10.1-0.1-0.1-0.10.1-0.4-0.5
Locomotion distance, session 80.10.10.30.40.50.40.6-0.60.40.10.00.30.30.20.10.2
Degree of sensitization distance1.21.31.8-1.2-1.0-1.2-1.01.1-1.1-1.3-1.0-1.2-1.2-1.4-1.0-0.8
Degree of sensitization stereotypy0.10.10.7-0.1-0.3-0.1-0.20.3-0.10.1-0.8-0.10.00.2-0.1-0.3
Conditioned locomotion2.52.84.21.82.01.71.8-2.11.81.51.11.61.51.41.51.8
Cocaine response after cond. corrected2.12.53.81.61.51.61.5-1.31.51.71.91.71.61.81.51.3
Cocaine response after cond. not corrected3.03.64.11.91.92.02.0-2.01.91.91.52.01.92.01.61.9
Cocaine response before conditioning0.60.81.20.91.00.91.0-1.11.00.6-0.40.80.90.70.71.1
Saline control response0.60.81.31.00.71.00.6-0.70.91.11.11.01.11.10.70.4
Bone: connectivity density4.77.410.92.72.62.72.5-2.62.72.83.32.82.82.82.52.4
Bone: cortical apparent density1.01.42.21.11.01.11.0-0.91.01.31.51.11.11.31.51.2
Bone: cortical area0.71.01.41.11.01.11.0-1.21.11.00.91.11.10.80.71.0
Bone: cortical porosity1.01.11.71.01.01.00.9-1.01.01.10.81.01.01.21.31.2
Bone: cortical porosity1.21.31.91.11.01.10.9-1.01.01.21.31.11.11.21.41.1
Bone: cortical thickness0.10.10.50.20.10.20.1-0.20.30.20.20.40.30.10.30.7
Bone: cortical thickness1.61.93.31.31.41.31.5-1.31.41.21.41.41.31.01.61.8
Bone: cortical tissue density0.81.01.90.90.80.90.9-0.80.91.11.41.01.01.11.31.0
Condit. Reinf. active minus inactive responses0.30.40.7-0.6-0.6-0.5-0.60.6-0.6-0.5-0.6-0.6-0.6-0.6-0.7-0.8
Condit. Reinf. active-inactive response ratio0.30.41.0-0.5-0.6-0.4-0.50.6-0.5-0.3-0.9-0.5-0.4-0.6-0.6-1.0
Condit. Reinf. active responses0.40.51.00.80.70.80.6-0.70.70.81.00.80.70.70.60.5
Condit. Reinf. inactive responses1.92.35.41.41.41.41.3-1.31.41.42.31.61.41.51.41.6
Incentive salience index mean0.10.20.30.40.30.50.3-0.40.30.60.30.40.40.50.2-0.2
Condit. Reinf. lever presses1.01.42.61.31.11.31.1-1.21.21.51.11.21.31.60.90.3
Condit. Reinf. active minus inactive responses3.44.36.12.02.22.02.2-2.22.01.92.12.11.91.82.22.5
Condit. Reinf. active-inactive response ratio0.60.71.10.81.00.81.1-1.00.90.70.90.70.70.70.70.9
Condit. Reinf. active responses2.83.96.31.92.11.92.1-2.12.01.81.51.91.81.62.12.5
Condit. Reinf. inactive responses1.82.34.01.51.61.51.6-1.61.51.40.71.51.51.31.82.0
Condit. Reinf. lever presses1.82.53.41.51.71.51.7-1.61.61.41.51.51.41.41.81.8
Condit. Reinf. lever reinforcers received2.53.55.81.81.91.71.9-1.91.81.71.71.91.71.62.12.4
Conditioned reinforcement - actives0.10.20.60.40.60.40.6-0.80.40.50.50.30.30.30.30.1
Conditioned reinforcement - inactives1.72.53.31.61.41.61.7-1.31.61.81.41.61.61.81.81.1
Conditioned locomotion0.50.61.6-0.7-0.8-0.7-0.60.9-0.8-0.60.3-0.8-0.8-0.5-0.7-1.3
Patch foraging indifference point 0 sec0.30.51.4-0.7-0.8-0.6-0.80.9-0.7-0.5-0.4-0.7-0.5-0.4-0.7-1.2
Patch foraging indifference point AUC1.21.74.11.10.61.10.8-0.71.11.62.01.31.21.61.91.0
Delay disc. indifference point, 0s delay0.40.51.5-0.7-0.7-0.7-0.71.2-0.7-0.8-0.3-0.6-0.7-0.7-0.3-0.1
Delay disc. indifference point, 16s delay1.41.54.11.21.21.21.0-0.81.21.32.01.21.21.31.20.8
Delay disc. indifference point, 2s delay0.10.10.7-0.0-0.1-0.0-0.00.6-0.10.00.8-0.0-0.10.10.1-0.1
Delay disc. indifference point, 24s delay5.05.611.52.42.52.42.6-1.92.32.23.42.32.22.32.11.9
Delay disc. indifference point, 4s delay0.40.42.80.40.40.30.30.40.30.51.70.30.30.70.70.1
Delay disc. indifference point, 8s delay1.51.88.91.21.11.21.2-0.41.11.23.01.21.11.31.10.8
Indifference point function ln k0.10.21.2-0.10.3-0.00.3-0.30.0-0.4-1.1-0.1-0.1-0.4-0.60.2
Indifference point function log k0.10.21.2-0.10.3-0.00.3-0.30.0-0.4-1.1-0.1-0.1-0.4-0.60.2
Patch foraging total patch changes 0 sec0.20.51.2-0.6-0.7-0.6-0.80.9-0.6-0.5-0.4-0.7-0.5-0.3-0.7-1.1
Patch foraging total patch changes 12 sec0.91.22.0-1.1-1.4-1.1-1.41.3-1.1-0.9-0.5-1.0-1.0-0.9-0.8-1.1
Patch foraging total patch changes 18 sec0.10.20.5-0.3-0.7-0.3-0.60.6-0.40.2-0.0-0.3-0.10.30.2-0.7
Patch foraging total patch changes 24 sec1.42.43.5-1.6-1.6-1.6-1.71.8-1.6-1.4-0.8-1.7-1.5-1.3-1.3-1.9
Patch foraging total patch changes 6 sec0.10.20.6-0.3-0.7-0.3-0.50.8-0.3-0.10.4-0.2-0.10.10.0-0.6
Patch foraging time to switch 0 sec0.10.20.30.40.50.50.4-0.40.50.4-0.40.40.50.40.30.5
Patch foraging water rate 0 sec0.00.10.2-0.4-0.3-0.4-0.40.3-0.4-0.20.2-0.3-0.4-0.3-0.2-0.3
Patch foraging water rate 12 sec1.12.33.9-1.6-1.1-1.6-1.20.9-1.5-1.8-2.0-1.6-1.6-1.6-1.5-1.0
Patch foraging water rate 18 sec0.40.61.4-0.8-0.3-0.8-0.50.3-0.7-1.2-1.0-0.8-1.0-1.2-0.9-0.3
Patch foraging water rate 24 sec1.82.53.1-1.8-1.7-1.8-1.81.6-1.7-1.6-1.7-1.6-1.7-1.5-1.1-1.0
Patch foraging water rate 6 sec1.21.83.0-1.4-1.1-1.4-1.11.0-1.4-1.5-1.7-1.4-1.4-1.3-1.3-1.1
Seeking ratio, delayed vs. immediate footshock0.50.60.9-0.7-0.9-0.7-0.90.7-0.7-0.9-0.5-0.7-0.8-0.8-0.9-0.7
Distance traveled before self-admin0.10.11.10.10.30.00.2-0.50.1-0.11.10.0-0.0-0.2-0.30.1
Distance traveled after self-admin1.01.32.2-1.2-1.3-1.2-1.51.3-1.3-1.0-0.1-1.1-1.1-1.0-0.9-1.1
Extensor digitorum longus weight4.818.921.24.54.34.54.2-4.34.54.63.24.54.64.64.44.2
Bone: elastic displacement0.81.02.60.90.90.91.0-1.01.00.70.61.10.90.81.01.6
Bone: elastic work1.01.32.21.21.11.21.2-1.21.20.90.61.21.11.01.01.5
Bone: endosteal estimation0.30.61.70.91.10.91.0-1.30.90.50.60.60.60.4-0.20.1
Bone: endosteal perimeter0.10.30.70.60.70.60.6-0.80.50.40.90.40.40.3-0.2-0.1
Epididymis fat weight15.452.855.9-7.5-7.4-7.5-7.37.4-7.4-7.4-6.6-7.4-7.5-7.4-7.0-6.7
Delta time in closed arm before/after self-admin0.00.00.00.00.1-0.00.10.00.0-0.1-0.1-0.0-0.1-0.1-0.10.0
Delta time in open arm before/after self-admin0.70.71.60.70.10.80.4-0.40.71.20.70.91.01.21.30.7
Diff in mean of infusions in LGA sessions0.10.10.3-0.0-0.30.0-0.20.2-0.10.40.50.10.20.60.3-0.2
Delay discount exponential model param3.03.412.3-1.7-1.7-1.7-1.70.7-1.6-1.8-3.5-1.7-1.6-1.9-1.8-1.3
Extinction: sum of active levers before priming1.01.11.51.10.91.11.2-1.21.01.11.11.01.01.10.80.7
Active lever presses in extinction session 60.00.00.2-0.1-0.1-0.1-0.20.2-0.0-0.10.50.00.0-0.1-0.30.1
Bone: final force0.10.20.30.50.40.50.4-0.40.40.40.30.40.40.50.30.1
Bone: final moment0.10.20.30.50.40.50.4-0.60.50.40.20.40.40.50.20.1
Food consumed during 24 hour testing period0.10.20.50.40.40.40.3-0.20.40.20.70.40.30.50.50.6
Glucose0.50.71.1-0.9-0.9-0.9-1.01.0-1.0-0.6-0.2-0.9-0.8-0.7-0.7-1.1
Heart weight3.24.99.2-2.1-2.1-2.1-2.01.9-2.1-2.2-3.0-2.2-2.2-2.4-2.1-2.0
Delay discount hyperbolic model param2.22.510.7-1.4-1.4-1.4-1.40.4-1.3-1.5-3.3-1.4-1.3-1.6-1.5-1.0
Intermittent access intake day 1-15 change0.10.30.9-0.5-0.2-0.50.00.2-0.4-0.9-0.4-0.5-0.7-0.9-0.50.0
Intermittent access intake escalation0.20.51.3-0.7-0.3-0.7-0.20.3-0.6-1.0-0.7-0.7-0.9-1.1-0.6-0.1
Intermittent access intake escalation 20.50.51.4-0.7-0.4-0.8-0.20.5-0.7-1.1-0.4-0.8-0.9-1.2-0.7-0.2
Intermitt. access day 1 inactive lever presses0.20.63.20.70.50.70.4-0.40.60.91.80.70.70.80.6-0.0
Intermitt. access day 15 inactive lever presses1.42.95.71.81.41.81.7-1.31.71.92.41.71.81.81.61.1
Intermitt. access escalation Index0.50.71.9-0.9-1.4-0.9-1.11.2-0.9-0.6-0.4-0.7-0.7-0.5-0.3-0.7
Intermittent access day 1 total infusions2.43.86.81.91.71.91.7-1.41.82.32.62.02.02.32.11.3
Intermittent access day 15 total infusions0.60.92.20.91.00.91.2-0.90.90.91.50.90.80.80.90.7
Intermittent access terminal intake (last 3 days)1.31.83.01.31.31.31.5-1.11.21.41.71.31.31.31.41.0
Intermittent access total infusions1.41.73.81.31.31.31.4-1.11.21.52.01.21.21.31.30.8
Intermittent access day 1 locomotion1.72.14.21.51.21.51.1-0.81.41.72.01.51.51.71.51.0
Intermittent access day 15 total locomotion0.00.10.90.10.10.00.10.10.00.21.00.0-0.00.10.2-0.2
Intermittent access total locomotion0.10.21.50.20.10.20.10.10.10.41.20.20.20.40.4-0.1
Intermittent access standard deviation0.20.40.80.70.70.70.9-0.40.70.50.90.60.50.30.50.5
Left kidney weight0.00.10.20.20.30.20.4-0.40.10.20.40.20.10.20.20.2
Right kidney weight0.00.20.3-0.5-0.4-0.5-0.30.4-0.5-0.5-0.2-0.5-0.5-0.6-0.3-0.4
Cocaine induced anxiety0.10.10.30.30.10.30.2-0.10.30.40.50.30.40.50.20.0
Post-drug Anxiety1.31.42.3-1.2-1.3-1.2-1.41.4-1.2-1.0-0.4-1.2-1.1-0.9-1.2-1.5
Baseline Anxiety2.02.33.0-1.6-1.5-1.6-1.51.6-1.6-1.4-1.1-1.6-1.6-1.5-1.6-1.7
Tail length0.62.44.1-1.5-1.5-1.5-1.31.3-1.6-1.5-1.1-1.6-1.6-1.5-1.8-2.0
Length with tail1.98.210.1-2.9-2.7-2.9-2.72.7-3.0-3.0-1.7-3.0-3.0-2.9-3.1-3.2
Length without tail0.72.33.4-1.6-1.2-1.6-1.51.5-1.5-1.9-0.9-1.6-1.7-1.7-1.7-1.3
Times rat made contact with spout2.22.53.11.81.71.81.5-1.71.71.81.81.61.71.51.20.8
Lifetime Intake1.11.33.61.11.01.11.1-0.91.01.31.91.11.11.21.10.6
Liver weight, left3.96.48.6-2.6-2.6-2.5-2.82.6-2.6-2.3-1.9-2.6-2.4-2.4-2.5-2.9
Liver weight, right8.915.618.8-4.1-4.2-4.1-4.34.1-4.2-3.8-2.6-4.0-4.0-4.0-3.7-3.9
Locomotor activity0.10.21.40.30.10.3-0.1-0.00.20.31.20.30.30.40.1-0.1
Locomotor testing distance0.91.63.41.31.11.31.0-0.91.21.41.91.31.31.41.20.8
Locomotor testing rearing0.61.24.20.90.70.90.6-0.30.91.22.01.11.11.11.31.0
Locomotion in novel chamber0.91.12.5-1.0-1.1-1.1-1.10.8-1.0-1.1-1.6-1.0-1.0-0.9-1.0-0.9
Locomotion in novel chamber post-restriction1.93.04.0-1.8-1.8-1.8-1.82.0-1.9-1.7-1.0-1.8-1.8-1.6-1.7-1.7
Fecal boli incidents, locomotor time 10.50.71.40.90.90.90.9-1.20.90.9-0.20.80.80.80.90.7
Change in fecal boli incidents, locomotor task3.43.44.4-2.0-2.1-2.0-2.11.7-2.0-1.9-1.3-1.8-1.9-1.7-1.6-1.5
Time >=10cm from walls, locomotor time 10.20.20.70.30.30.30.3-0.70.30.20.80.40.20.10.50.8
Bouts of movement, locomotor time 13.33.85.32.12.32.12.2-1.82.11.91.11.92.01.81.91.7
Total resting periods, locomotor time 13.33.75.22.12.32.12.2-1.92.11.91.11.91.91.81.91.7
Rest time, locomotor task time 10.20.20.6-0.3-0.2-0.3-0.20.0-0.3-0.4-0.4-0.5-0.5-0.5-0.7-0.8
Distance moved, locomotor task time 10.40.62.0-0.8-1.1-0.8-1.01.4-0.8-0.6-0.5-0.7-0.6-0.6-0.3-0.5
Vertical activity count, locomotor time 10.10.30.6-0.6-0.5-0.6-0.50.8-0.6-0.7-0.2-0.6-0.6-0.7-0.5-0.4
Time >=10cm from walls, locomotor time 20.20.22.40.10.10.00.0-0.40.00.01.50.20.0-0.10.20.6
Bouts of movement, locomotor time 20.10.10.3-0.20.0-0.30.0-0.1-0.2-0.6-0.2-0.3-0.5-0.6-0.5-0.0
Total resting periods, locomotor time 20.00.10.2-0.00.2-0.10.2-0.4-0.0-0.3-0.2-0.1-0.3-0.4-0.30.2
Rest time, locomotor task time 21.51.93.01.41.51.41.5-1.71.41.40.81.31.31.31.31.2
Distance moved, locomotor task time 21.11.43.3-1.2-1.4-1.2-1.31.8-1.2-1.1-0.6-1.0-1.1-1.1-0.9-0.8
Vertical activity count, locomotor time 21.21.72.7-1.3-1.1-1.3-1.11.3-1.2-1.6-1.1-1.3-1.4-1.6-1.4-0.9
Light reinforcement 13.17.79.92.92.52.92.4-2.32.93.02.22.93.02.93.12.7
Light reinforcement 22.33.54.22.01.92.01.9-1.62.01.91.52.02.01.81.81.6
Bone: marrow area0.30.61.70.91.10.91.0-1.30.90.50.60.60.60.4-0.20.2
Bone: maximum diameter1.22.23.01.61.61.61.5-1.71.51.51.71.51.51.20.91.1
Bone: maximum force0.10.20.30.50.40.50.4-0.60.50.40.10.50.50.40.30.4
Bone: maximum moment0.10.20.50.60.50.60.5-0.70.60.40.10.50.50.50.30.4
Mean time between licks in bursts1.63.85.3-2.0-1.8-2.0-1.91.8-1.9-2.0-2.3-2.1-2.0-1.9-2.0-1.8
Mean num. licks in bursts0.10.10.20.40.30.40.4-0.40.40.20.00.30.3-0.00.00.1
Cd content in liver0.10.10.20.30.20.30.2-0.20.30.30.20.30.40.40.40.3
Co content in liver8.09.310.03.12.83.13.0-2.73.13.13.13.23.23.13.12.9
Cu content in liver0.20.30.80.50.30.60.4-0.70.40.60.90.50.60.60.1-0.1
Fe content in liver0.60.84.30.80.80.70.7-0.70.60.72.10.80.70.70.60.4
K content in liver0.20.20.50.30.50.30.6-0.70.3-0.0-0.2-0.1-0.0-0.2-0.7-0.6
Mg content in liver0.30.40.80.60.70.60.7-0.90.50.40.50.30.40.3-0.5-0.8
Mn content in liver0.00.00.40.10.10.10.1-0.20.1-0.0-0.7-0.00.0-0.1-0.10.0
Na content in liver0.20.20.60.40.60.40.5-0.80.30.10.10.10.10.1-0.6-0.5
Rb content in liver0.10.10.40.30.20.30.3-0.30.20.10.40.10.20.3-0.3-0.6
Se content in liver0.30.40.6-0.6-0.7-0.6-0.70.8-0.7-0.4-0.2-0.6-0.5-0.5-0.3-0.8
Sr content in liver0.40.41.2-0.4-0.2-0.4-0.3-0.1-0.4-0.7-1.1-0.6-0.6-0.7-1.0-0.6
Zn content in liver0.40.51.1-0.7-1.0-0.7-0.80.5-0.8-0.5-0.2-0.6-0.6-0.4-0.8-1.0
Bone: minimum diameter0.10.21.0-0.2-0.2-0.2-0.30.0-0.2-0.3-0.2-0.3-0.3-0.3-1.0-0.9
Time in familiar zone, hab. session 10.70.61.0-0.8-0.9-0.8-1.00.9-0.8-0.6-0.5-0.8-0.7-0.7-0.6-1.0
Time in novel zone, hab. session 10.60.61.3-0.8-0.9-0.8-0.80.8-0.8-0.8-1.1-0.7-0.7-0.7-0.6-0.3
Total zone transitions, hab. session 10.10.20.50.40.40.40.4-0.50.40.30.70.50.40.30.30.6
Total locomotion distance, hab. session 10.00.10.20.20.40.20.2-0.30.3-0.10.20.20.10.0-0.00.5
Locomotion velocity, hab. session 10.81.11.71.11.31.11.1-1.21.10.71.11.10.90.80.81.3
Time in familiar zone, hab. session 20.00.10.3-0.1-0.4-0.0-0.20.4-0.10.0-0.0-0.1-0.0-0.1-0.0-0.6
Time in novel zone, hab. session 20.20.20.4-0.6-0.4-0.6-0.40.4-0.5-0.6-0.4-0.5-0.6-0.6-0.50.1
Total zone transitions, hab. session 20.10.20.40.50.50.50.4-0.70.50.00.60.40.30.2-0.10.2
Total locomotion distance, hab. session 20.10.20.50.40.70.40.5-0.70.50.10.30.30.20.20.00.4
Locomotion velocity, hab. session 20.30.41.00.70.90.70.8-1.00.70.40.50.60.50.50.30.6
Novel to familiar place preference ratio0.30.40.9-0.7-0.5-0.7-0.40.1-0.6-0.8-1.0-0.5-0.7-0.6-0.50.3
Novelty place preference0.70.71.5-1.0-0.8-1.0-0.70.4-0.9-1.1-1.2-0.8-1.0-0.9-0.8-0.0
Time in novel zone, NPP test0.91.01.6-1.1-1.0-1.1-0.90.6-1.0-1.3-1.3-1.0-1.1-1.0-1.0-0.2
Total zone transitions, NPP test1.21.72.21.51.41.51.4-1.21.51.11.51.41.31.20.91.1
Total locomotion distance, NPP test1.41.82.61.51.61.51.6-1.41.50.91.31.41.21.10.91.5
Locomotion velocity, NPP test2.83.95.02.12.22.12.2-2.02.21.61.72.01.91.81.62.0
Intraocular pressure2.94.25.5-2.1-1.9-2.1-1.92.1-2.2-2.2-0.6-2.1-2.2-2.3-2.3-2.1
Delta distance traveled before/after self-admin2.22.33.5-1.6-1.8-1.6-1.91.8-1.6-1.2-1.5-1.4-1.4-1.2-1.1-1.4
Delta ambulatory time before/after self-admin0.30.41.5-0.6-0.8-0.6-0.91.2-0.6-0.3-0.2-0.4-0.4-0.2-0.0-0.5
Parametrial fat weight9.021.130.4-4.8-5.2-4.7-5.25.5-4.8-4.2-3.7-4.6-4.4-4.1-3.8-4.4
Pavlov. Cond. lever latency1.62.02.7-1.5-1.4-1.5-1.41.5-1.4-1.6-1.7-1.4-1.4-1.5-1.0-0.6
Pavlov. Cond. magazine entry latency0.00.10.10.30.30.30.3-0.30.20.20.10.10.20.2-0.2-0.4
Pavlov. Cond. change in total contacts0.10.10.60.20.20.20.1-0.10.10.10.5-0.0-0.00.0-0.5-0.8
Pavlov. Cond. index score0.50.60.80.90.90.90.9-0.90.80.90.90.70.80.90.40.0
Pavlov. Cond. latency score0.50.60.90.90.90.90.9-0.90.80.81.00.70.70.80.30.0
Pavlov. Cond. lever contacts0.91.11.41.21.21.21.1-1.21.11.21.11.01.11.10.50.2
Pavlov. Cond. magazine entry number0.20.20.4-0.6-0.7-0.6-0.60.6-0.5-0.4-0.3-0.4-0.4-0.4-0.1-0.0
Pavlov. Cond. intertrial magazine entries1.92.34.21.41.31.41.3-1.21.41.72.01.51.51.51.81.5
Pavlov. Cond. lever-magazine prob. diff.1.21.51.81.31.31.31.3-1.31.21.31.31.21.21.30.80.5
Pavlov. Cond. response bias0.81.01.41.11.21.11.1-1.21.11.00.80.91.01.00.60.3
Pavlov. Cond. lever latency1.21.61.9-1.3-1.4-1.3-1.31.3-1.3-1.3-0.9-1.2-1.3-1.2-1.4-1.2
Pavlov. Cond. magazine entry latency0.10.10.10.30.30.30.2-0.30.30.2-0.00.30.30.30.20.2
Pavlov. Cond. change in total contacts0.50.81.30.91.10.81.1-1.10.80.81.10.80.70.60.90.9
Pavlov. Cond. index score0.70.91.40.91.10.91.0-1.20.90.80.60.90.80.80.91.0
Pavlov. Cond. latency score0.60.81.10.91.10.91.0-1.10.90.80.70.90.80.70.91.0
Pavlov. Cond. lever contacts0.81.11.61.11.21.01.1-1.11.11.10.81.01.01.01.21.1
Pavlov. Cond. magazine entry number0.10.10.1-0.3-0.4-0.3-0.30.3-0.3-0.2-0.1-0.2-0.3-0.2-0.3-0.2
Pavlov. Cond. intertrial magazine entries2.23.34.6-1.9-2.0-1.9-1.82.0-1.9-1.7-2.1-1.8-1.8-1.7-1.4-1.4
Pavlov. Cond. lever-magazine prob. diff.0.30.50.80.70.90.60.8-0.90.70.50.40.60.60.50.70.8
Pavlov. Cond. response bias1.41.92.51.41.61.41.5-1.51.41.30.71.31.31.31.51.4
Time in closed arm before self-admin0.91.21.9-1.2-1.2-1.2-1.01.4-1.1-1.1-1.2-1.0-1.1-1.1-0.7-0.6
Time in closed arm after self-admin1.51.62.7-1.4-1.3-1.4-1.31.6-1.3-1.3-1.1-1.3-1.3-1.3-1.0-0.9
Time in open arm before self-admin0.20.20.60.50.80.50.5-0.70.50.30.60.30.30.2-0.00.1
Time in open arm after self-admin2.02.23.11.61.21.61.2-1.41.51.81.51.51.61.81.51.0
Bone: periosteal estimation0.71.42.81.41.51.41.4-1.71.41.01.11.21.10.80.40.8
Bone: periosteal perimeter0.30.61.10.80.90.80.8-1.00.90.70.70.70.70.50.20.5
Bone: post-yield work0.60.91.31.01.01.01.0-1.21.01.00.70.91.00.80.70.7
Progressive ratio test 1 active lever presses0.81.01.31.01.01.00.9-1.10.91.11.11.01.01.00.90.6
Progressive ratio test 1 breakpoint0.91.01.41.01.01.00.9-1.11.01.21.11.01.01.11.00.6
Progressive ratio test 1 inactive lever presses1.11.64.41.20.71.20.9-1.01.11.52.11.31.31.61.40.8
Progressive ratio test 2 active lever presses0.10.10.40.10.50.10.3-0.10.00.10.6-0.1-0.00.0-0.1-0.3
Progressive ratio test 2 breakpoint0.00.10.20.00.40.00.3-0.0-0.1-0.00.5-0.1-0.1-0.1-0.2-0.3
Progressive ratio test 2 inactive lever presses0.10.21.20.40.60.40.5-0.20.30.51.10.30.30.50.40.1
Incentive Sensitization - Responses0.00.10.40.10.60.10.5-0.10.1-0.10.1-0.0-0.1-0.20.00.2
Incentive Sensitization - Breakpoint0.00.00.2-0.10.4-0.10.30.1-0.1-0.30.0-0.2-0.2-0.3-0.20.1
Sum of active levers in priming session hrs 5-61.21.11.81.11.11.11.2-1.31.11.10.81.01.01.00.80.7
Progressive ratio1.01.51.8-1.3-1.4-1.3-1.21.2-1.3-1.3-1.0-1.2-1.3-1.4-1.2-1.0
Food seeking constrained by brief footshock1.72.12.91.51.31.41.5-1.51.41.51.21.51.41.51.71.4
Seeking ratio, punishment vs. effort1.42.12.71.41.41.41.4-1.41.41.51.31.41.41.51.71.4
Retroperitoneal fat weight20.487.0100.9-9.6-9.8-9.6-9.910.0-9.6-9.2-8.1-9.4-9.4-9.0-8.6-8.8
Reaction time number correct0.61.11.81.01.21.01.3-1.21.00.81.31.00.80.60.91.2
Reaction time mean minus median0.00.10.10.20.20.2-0.0-0.30.20.30.00.30.40.30.30.3
Reaction time mean minus median AUC0.00.00.1-0.0-0.00.0-0.20.0-0.00.00.20.10.10.10.10.2
Reaction time num false alarms0.30.40.80.70.60.70.6-0.50.60.80.30.60.70.80.90.4
Reaction time num false alarms AUC0.50.81.20.90.80.90.9-0.80.91.00.50.90.90.91.10.7
Reaction time trials correct on left0.61.11.81.01.21.01.3-1.21.00.81.31.00.80.60.91.2
Reaction time trials on left0.61.21.91.01.21.01.3-1.31.00.81.41.00.90.70.91.3
Reaction time mean0.50.81.4-0.9-1.1-0.9-1.21.0-1.0-0.5-0.5-0.8-0.7-0.4-0.6-1.2
Reaction time mean AUC0.40.61.2-0.8-1.1-0.8-1.10.9-0.9-0.4-0.4-0.6-0.5-0.2-0.5-1.0
Median of all reaction times0.71.01.9-1.0-1.3-1.0-1.31.2-1.1-0.5-0.5-0.9-0.8-0.4-0.7-1.4
Reaction time omissions0.10.10.20.30.20.30.00.10.30.40.40.40.40.30.50.4
Reaction time false alarm rate0.10.10.20.20.10.20.10.00.20.4-0.20.20.30.40.4-0.1
Reaction time premature initiation rate0.10.20.5-0.4-0.4-0.4-0.40.3-0.4-0.3-0.7-0.5-0.4-0.4-0.4-0.6
Reaction time premature initiations0.00.00.20.10.30.10.3-0.40.20.10.10.10.1-0.10.10.2
Std. dev. reaction times0.10.20.5-0.5-0.6-0.5-0.70.5-0.6-0.3-0.6-0.4-0.3-0.3-0.3-0.5
Reaction time trials completed0.61.21.91.01.21.01.3-1.31.00.81.41.00.90.70.91.3
Reaction time trials AUC0.81.52.41.21.31.11.5-1.41.10.91.51.21.00.81.01.4
Run reversals in cocaine runway, females0.10.11.10.00.30.00.3-0.50.1-0.1-1.1-0.0-0.0-0.00.20.4
Run reversals in cocaine runway, males0.50.61.00.70.70.71.0-0.90.80.60.30.70.60.60.71.0
Latency to leave start box in cocaine runway0.30.30.40.60.50.60.4-0.60.60.60.40.60.60.60.50.6
Latency to leave start box in cocaine runway, F0.20.30.40.60.50.60.6-0.60.60.50.20.60.60.50.30.5
Latency to leave start box in cocaine runway, M0.10.10.2-0.3-0.4-0.3-0.50.1-0.3-0.10.1-0.2-0.20.00.1-0.1
Std. dev. time between licks in bursts0.10.10.2-0.2-0.3-0.2-0.50.4-0.30.20.4-0.1-0.00.20.4-0.2
Total sessions with >9 infusions0.10.10.40.1-0.20.1-0.3-0.10.10.30.70.20.20.30.1-0.2
Short access day 1 total inactive lever presses4.66.19.52.52.12.52.2-2.32.42.63.12.62.52.62.52.1
Short access day 10 total inactive lever presses1.22.86.31.61.51.61.5-1.21.61.72.51.71.61.71.91.6
Short access day 1 total infusions0.81.02.60.90.50.90.4-0.50.91.31.61.01.11.31.30.6
Short access day 10 total infusions1.51.92.81.41.31.41.3-1.51.31.71.61.31.41.51.30.9
Short access total infusions0.10.21.30.30.00.30.0-0.00.20.51.10.30.30.40.4-0.2
Short access day 1 locomotion1.11.43.21.20.91.20.9-1.11.11.41.81.21.21.31.20.8
Short access day 10 total locomotion1.12.02.71.51.31.51.4-1.51.51.71.21.51.51.61.30.9
Short access total locomotion0.00.00.20.0-0.20.0-0.30.20.00.20.40.00.10.10.1-0.3
One hour access (0.3 mA shock)0.30.42.50.50.70.50.5-0.30.40.61.60.40.40.40.40.0
Compulsive drug intake0.30.40.9-0.7-0.7-0.7-1.00.8-0.6-0.60.1-0.5-0.6-0.7-0.4-0.2
One hour access (shock baseline)0.91.31.91.21.31.21.4-1.11.11.31.41.01.11.21.00.6
Social response proportion0.50.51.1-0.8-1.0-0.8-1.10.9-0.8-0.50.2-0.7-0.5-0.4-0.4-0.7
Social responses0.10.10.5-0.2-0.5-0.2-0.50.7-0.30.10.4-0.10.00.20.3-0.2
Social time0.70.91.6-1.0-1.1-1.0-1.31.2-1.0-0.8-0.5-0.9-0.8-0.6-0.7-1.0
Soleus weight5.817.019.04.34.14.44.2-4.04.34.33.24.34.34.13.94.0
Bone: stiffness0.00.00.00.10.10.10.1-0.20.10.10.00.00.10.10.0-0.1
Tibialis anterior weight4.615.518.94.13.84.13.9-3.64.14.22.54.14.24.34.03.9
Time to tail flick, vehicle, before self-admin1.01.04.3-1.0-1.0-0.9-0.60.7-1.0-0.9-2.1-0.9-0.9-0.8-0.8-0.7
Time to tail flick, vehicle, after self-admin2.43.14.7-1.7-1.8-1.7-1.51.4-1.8-1.8-2.2-1.7-1.7-1.8-1.9-1.8
Time to tail flick, test, before self-admin0.10.10.30.30.30.30.1-0.00.30.30.60.40.30.30.50.4
Time to tail flick, test, after self-admin0.20.20.40.40.60.40.5-0.70.40.3-0.40.30.30.30.20.4
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.20.0-0.2-0.1-0.0-0.2-0.5-0.2-0.3-0.2-0.5-0.7-0.5
Delta time to tail flick, test, before/after SA1.31.43.01.21.51.21.4-1.71.21.00.31.01.11.00.81.0
Tibia length3.18.610.9-3.0-3.1-3.0-3.02.9-3.1-3.0-1.6-3.0-3.0-2.8-3.1-3.3
Ambulatory time before self-admin0.10.20.90.30.50.20.4-0.60.30.11.00.20.1-0.0-0.10.2
Ambulatory time after self-admin0.70.81.4-0.9-1.1-0.9-1.21.2-1.0-0.7-0.0-0.8-0.8-0.7-0.5-0.8
Bone: tissue strength0.40.40.8-0.6-0.7-0.6-0.70.7-0.6-0.5-0.9-0.6-0.5-0.5-0.4-0.6
Total heroin consumption3.33.84.32.11.82.11.9-1.82.02.02.02.02.02.01.91.7
Bone: trabecular number4.06.68.32.62.32.62.2-2.42.52.82.82.72.72.92.52.2
Bone: trabecular spacing2.02.63.4-1.6-1.6-1.5-1.51.7-1.5-1.6-1.8-1.6-1.5-1.7-1.5-1.7
Bone: trabecular thickness0.60.81.20.90.90.90.7-0.90.91.00.30.91.01.10.80.8
Bone: trabecular tissue density0.20.30.40.50.60.50.6-0.60.50.60.30.40.50.60.70.4
Water consumed over 24 hours0.30.40.70.70.80.70.8-0.70.70.60.60.60.60.60.40.3
Number of responses in last shaping day0.40.41.4-0.5-0.3-0.5-0.40.2-0.5-0.70.3-0.6-0.6-0.7-1.2-1.0