Hub : Genes

Pcare

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Pcare 0.12 0.08 5.1e-07 0.1 0.11 0.1 0.1 8.0e-06 2.1e-06 6.5e-06 6.8e-06
2 Liver gene expression Pcare 0.04 0.04 3.0e-04 0.02 0.02 0.02 0.02 9.3e-04 1.3e-03 4.7e-03 2.0e-03
3 PL gene expression Pcare 0.1 0.06 4.4e-16 0.13 0.15 0.14 0.14 2.5e-14 1.0e-15 3.8e-15 3.1e-15
4 IL gene expression Pcare 0.19 0.16 6.9e-03 0.02 0.01 0.01 0.01 8.8e-02 2.2e-01 1.7e-01 1.6e-01
5 pVTA alternative TSS XM_006239771.5 0.06 0.05 5.5e-05 0.06 0.06 0.06 0.06 2.1e-05 2.0e-05 1.7e-05 1.6e-05
6 Adipose gene expression Pcare 0.09 0.07 1.7e-08 0.06 0.06 0.06 0.06 2.5e-07 1.7e-07 1.8e-07 3.7e-07
7 RMTg gene expression Pcare 0.12 0.13 7.4e-03 0.08 0.08 0.08 0.08 4.1e-03 4.6e-03 3.2e-03 4.0e-03
8 IC gene expression Pcare 0.28 0.17 6.6e-09 0.17 0.2 0.18 0.21 1.6e-07 8.2e-09 5.0e-08 3.6e-09
9 LHb gene expression Pcare 0.49 0.27 1.4e-07 0.18 0.23 0.22 0.22 3.7e-05 4.5e-06 6.2e-06 5.8e-06
10 pVTA gene expression Pcare 0.28 0.15 0.0e+00 0.31 0.33 0.33 0.33 1.9e-25 6.8e-27 3.0e-27 2.9e-27
11 OFC gene expression Pcare 0.25 0.18 1.5e-04 0.13 0.12 0.07 0.12 4.8e-04 6.9e-04 9.9e-03 7.1e-04
12 Brain gene expression Pcare 0.3 0.11 0.0e+00 0.42 0.41 0.42 0.42 1.5e-41 3.1e-41 1.2e-41 1.4e-41
13 NAcc gene expression Pcare 0.17 0.13 1.1e-07 0.04 0.05 0.04 0.04 7.3e-07 1.0e-07 2.0e-07 7.5e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density4.58.39.52.9-2.82.9-2.6-2.82.9-3.13.13.03.0-3.0-2.72.6
Area under the delay curve1.62.510.61.4-1.41.4-1.4-0.41.3-3.21.51.41.3-1.6-1.51.1
BMI with tail0.10.30.8-0.60.7-0.60.60.7-0.60.9-0.6-0.5-0.50.50.2-0.0
BMI without tail0.21.01.8-1.11.3-1.01.01.3-1.11.1-0.8-0.9-0.90.80.6-1.0
Body weight1.56.47.6-2.62.6-2.62.62.8-2.71.8-2.5-2.6-2.62.42.4-2.5
Weight adjusted by age0.00.10.2-0.30.2-0.30.20.3-0.30.3-0.3-0.3-0.30.30.2-0.4
Bone surface1.73.46.11.9-1.91.9-1.9-2.11.8-2.51.81.81.7-1.7-1.21.3
Bone volume2.04.16.62.1-2.02.1-1.9-2.22.0-2.62.12.02.0-2.0-1.51.5
Breakpoint value in progressive ratio session0.40.71.10.8-0.70.8-0.7-0.60.8-0.91.00.80.9-1.0-0.70.4
Number of licking bursts0.10.31.10.5-0.50.5-0.3-0.50.4-1.10.70.50.5-0.8-0.60.2
Context. condit. distance diff. score0.10.10.3-0.20.1-0.30.00.1-0.20.4-0.4-0.3-0.40.50.3-0.1
Locomotion velocity, session 10.10.10.3-0.30.4-0.30.40.4-0.3-0.1-0.4-0.2-0.30.30.6-0.5
Locomotion distance, session 11.82.32.91.6-1.61.6-1.6-1.51.6-1.71.41.61.6-1.4-1.11.4
Locomotion velocity, session 20.20.30.7-0.40.3-0.40.40.3-0.50.2-0.6-0.5-0.50.50.9-0.9
Locomotion distance, session 20.00.00.20.00.10.00.20.2-0.0-0.5-0.1-0.00.0-0.10.3-0.4
Locomotion velocity, session 30.30.40.70.7-0.80.7-0.7-0.70.70.20.60.50.7-0.7-0.30.2
Locomotion distance, session 30.70.91.41.0-0.91.0-0.8-0.81.0-0.71.10.91.1-1.2-0.80.4
Stereotopy head waving bouts, day 31.01.21.91.1-1.41.1-1.2-1.41.1-1.41.11.01.0-0.9-0.90.8
Stereotopy head waving duration, day 30.00.00.10.1-0.30.1-0.1-0.30.1-0.10.0-0.00.00.10.1-0.1
Locomotion velocity, session 70.50.60.80.9-0.90.9-0.9-0.80.9-0.10.90.70.9-0.8-0.60.2
Locomotion distance, session 70.10.10.3-0.20.1-0.20.20.2-0.20.3-0.3-0.3-0.20.20.4-0.5
Stereotopy head waving bouts, day 70.10.10.20.2-0.10.2-0.1-0.10.20.30.40.20.3-0.4-0.30.1
Stereotopy head waving duration, day 70.40.51.00.8-0.60.8-0.6-0.60.7-0.11.00.80.9-0.9-0.80.5
Locomotion velocity, session 80.00.00.2-0.10.1-0.10.2-0.1-0.10.10.1-0.1-0.1-0.10.4-0.5
Locomotion distance, session 80.10.10.30.4-0.50.4-0.6-0.60.4-0.10.10.30.3-0.2-0.10.2
Degree of sensitization distance1.21.31.8-1.21.0-1.21.01.1-1.11.0-1.3-1.2-1.21.41.0-0.8
Degree of sensitization stereotypy0.10.10.7-0.10.3-0.10.20.3-0.10.80.1-0.10.0-0.20.1-0.3
Conditioned locomotion2.42.84.21.8-2.01.7-1.8-2.11.8-1.11.51.61.5-1.4-1.51.8
Cocaine response after cond. corrected1.72.53.81.6-1.51.6-1.5-1.31.5-1.91.71.71.6-1.8-1.51.3
Cocaine response after cond. not corrected2.53.64.11.9-1.92.0-2.0-2.01.9-1.51.92.01.9-2.0-1.61.9
Cocaine response before conditioning0.60.81.20.9-1.00.9-1.0-1.11.00.40.60.80.9-0.7-0.71.1
Saline control response0.60.81.21.0-0.71.0-0.6-0.70.9-1.11.11.01.1-1.1-0.70.4
Bone: connectivity density4.67.410.92.7-2.62.7-2.5-2.62.7-3.32.82.82.8-2.8-2.52.4
Bone: cortical apparent density0.91.42.21.1-1.01.1-1.0-0.91.0-1.51.31.11.1-1.3-1.51.2
Bone: cortical area0.61.01.41.1-1.01.1-1.0-1.21.1-0.91.01.11.1-0.8-0.71.0
Bone: cortical porosity1.01.11.71.0-1.01.0-0.9-1.01.0-0.81.11.01.0-1.2-1.31.2
Bone: cortical porosity1.21.31.91.1-1.01.1-0.9-1.01.0-1.31.21.11.1-1.2-1.41.1
Bone: cortical thickness0.10.10.50.2-0.10.2-0.1-0.20.3-0.20.20.40.3-0.1-0.30.7
Bone: cortical thickness1.51.93.31.3-1.41.3-1.5-1.31.4-1.41.21.41.3-1.0-1.61.8
Bone: cortical tissue density0.71.01.90.9-0.80.9-0.9-0.80.9-1.41.11.01.0-1.1-1.31.0
Condit. Reinf. active minus inactive responses0.30.40.7-0.60.6-0.50.60.6-0.60.6-0.5-0.6-0.60.60.7-0.8
Condit. Reinf. active-inactive response ratio0.30.41.0-0.50.6-0.40.50.6-0.50.9-0.3-0.5-0.40.60.6-1.0
Condit. Reinf. active responses0.40.51.00.8-0.70.8-0.6-0.70.7-1.00.80.80.7-0.7-0.60.5
Condit. Reinf. inactive responses1.82.35.41.4-1.41.4-1.3-1.31.4-2.31.41.61.4-1.5-1.41.6
Incentive salience index mean0.10.10.30.4-0.30.5-0.3-0.40.3-0.30.60.40.4-0.5-0.2-0.2
Condit. Reinf. lever presses1.01.42.61.3-1.11.3-1.1-1.21.2-1.11.51.21.3-1.6-0.80.3
Condit. Reinf. active minus inactive responses2.84.46.12.0-2.22.0-2.2-2.22.0-2.11.92.11.9-1.8-2.22.5
Condit. Reinf. active-inactive response ratio0.50.71.10.8-1.00.8-1.1-1.00.9-0.90.70.70.7-0.7-0.70.9
Condit. Reinf. active responses2.73.96.31.9-2.11.9-2.1-2.12.0-1.51.81.91.8-1.6-2.12.5
Condit. Reinf. inactive responses1.52.34.01.5-1.61.5-1.6-1.61.5-0.71.41.51.5-1.3-1.82.0
Condit. Reinf. lever presses1.72.53.41.5-1.71.5-1.7-1.61.6-1.61.41.51.4-1.4-1.91.8
Condit. Reinf. lever reinforcers received2.53.55.81.8-1.91.7-1.9-1.91.8-1.71.71.91.7-1.6-2.12.4
Conditioned reinforcement - actives0.10.20.60.4-0.60.4-0.6-0.80.4-0.50.50.30.3-0.3-0.30.1
Conditioned reinforcement - inactives0.92.53.31.6-1.41.6-1.7-1.31.6-1.41.81.61.6-1.8-1.81.1
Conditioned locomotion0.40.61.6-0.70.8-0.70.60.9-0.8-0.3-0.6-0.8-0.80.50.7-1.3
Patch foraging indifference point 0 sec0.20.51.4-0.70.8-0.60.80.9-0.70.4-0.5-0.7-0.50.40.7-1.2
Patch foraging indifference point AUC0.71.74.01.1-0.61.1-0.8-0.71.1-2.01.61.31.2-1.6-1.91.0
Delay disc. indifference point, 0s delay0.40.51.5-0.70.7-0.70.71.2-0.70.3-0.8-0.6-0.70.70.3-0.1
Delay disc. indifference point, 16s delay1.11.54.01.2-1.21.2-1.0-0.81.2-2.01.31.21.2-1.3-1.20.8
Delay disc. indifference point, 2s delay0.10.10.7-0.00.1-0.00.00.6-0.1-0.80.0-0.0-0.1-0.1-0.1-0.1
Delay disc. indifference point, 24s delay3.55.611.52.4-2.52.4-2.6-1.92.3-3.42.22.32.2-2.3-2.11.9
Delay disc. indifference point, 4s delay0.40.42.70.4-0.40.3-0.30.40.3-1.60.50.30.3-0.7-0.70.1
Delay disc. indifference point, 8s delay1.11.88.81.2-1.11.2-1.2-0.41.1-3.01.21.21.1-1.3-1.10.8
Indifference point function ln k0.10.21.2-0.1-0.3-0.0-0.3-0.30.01.1-0.4-0.1-0.10.40.60.2
Indifference point function log k0.10.21.2-0.1-0.3-0.0-0.3-0.30.01.1-0.4-0.1-0.10.40.60.2
Patch foraging total patch changes 0 sec0.20.51.2-0.60.7-0.60.80.9-0.60.5-0.5-0.7-0.50.30.7-1.1
Patch foraging total patch changes 12 sec0.91.22.0-1.11.4-1.11.41.3-1.10.5-0.9-1.0-1.00.90.8-1.1
Patch foraging total patch changes 18 sec0.10.20.5-0.30.7-0.30.60.6-0.40.10.2-0.3-0.1-0.3-0.2-0.7
Patch foraging total patch changes 24 sec0.72.43.5-1.61.6-1.61.71.8-1.60.8-1.4-1.7-1.51.31.3-1.9
Patch foraging total patch changes 6 sec0.10.20.6-0.30.7-0.30.50.8-0.3-0.3-0.1-0.2-0.1-0.1-0.0-0.6
Patch foraging time to switch 0 sec0.00.20.30.4-0.50.5-0.4-0.40.50.40.40.40.5-0.4-0.30.5
Patch foraging water rate 0 sec0.00.10.2-0.40.3-0.40.40.3-0.4-0.2-0.2-0.3-0.40.30.2-0.3
Patch foraging water rate 12 sec0.62.33.9-1.61.1-1.61.20.9-1.52.0-1.8-1.6-1.61.61.5-1.0
Patch foraging water rate 18 sec0.30.61.4-0.80.3-0.80.50.3-0.71.0-1.2-0.8-1.01.20.9-0.3
Patch foraging water rate 24 sec1.82.53.1-1.81.7-1.81.81.6-1.71.7-1.6-1.6-1.71.51.1-1.0
Patch foraging water rate 6 sec1.21.83.0-1.41.1-1.41.11.0-1.41.7-1.5-1.4-1.41.31.3-1.1
Seeking ratio, delayed vs. immediate footshock0.40.60.9-0.70.9-0.70.90.7-0.70.5-0.9-0.7-0.80.81.0-0.7
Distance traveled before self-admin0.10.11.10.1-0.30.0-0.2-0.50.1-1.1-0.10.0-0.00.20.30.1
Distance traveled after self-admin0.71.32.2-1.21.3-1.21.51.3-1.30.1-1.0-1.1-1.11.00.9-1.1
Extensor digitorum longus weight4.718.921.24.5-4.34.5-4.2-4.34.5-3.34.64.54.6-4.6-4.44.2
Bone: elastic displacement0.81.02.60.9-0.90.9-1.0-1.01.0-0.60.71.10.9-0.8-1.01.6
Bone: elastic work1.01.32.21.2-1.11.2-1.2-1.21.2-0.60.91.21.1-1.0-1.01.5
Bone: endosteal estimation0.20.61.70.9-1.10.9-1.0-1.30.9-0.60.50.60.6-0.40.20.1
Bone: endosteal perimeter0.10.30.80.6-0.70.6-0.6-0.80.5-0.90.40.40.4-0.30.2-0.1
Epididymis fat weight10.552.855.9-7.57.4-7.57.37.4-7.46.6-7.4-7.4-7.57.47.0-6.7
Delta time in closed arm before/after self-admin0.00.00.00.0-0.1-0.0-0.10.00.00.1-0.1-0.0-0.10.10.10.0
Delta time in open arm before/after self-admin0.60.71.60.7-0.10.8-0.4-0.40.7-0.61.20.91.0-1.2-1.30.7
Diff in mean of infusions in LGA sessions0.00.10.3-0.00.30.00.20.2-0.1-0.50.40.10.2-0.6-0.3-0.2
Delay discount exponential model param2.53.412.2-1.71.7-1.71.70.7-1.63.5-1.8-1.7-1.61.91.8-1.3
Extinction: sum of active levers before priming0.71.11.51.1-0.91.1-1.2-1.21.0-1.11.11.01.0-1.1-0.80.7
Active lever presses in extinction session 60.00.00.2-0.10.1-0.10.20.2-0.0-0.5-0.10.00.00.10.30.1
Bone: final force0.10.20.30.5-0.40.5-0.4-0.40.4-0.30.40.40.4-0.5-0.30.1
Bone: final moment0.10.20.30.5-0.40.5-0.4-0.60.5-0.20.40.40.4-0.5-0.20.1
Food consumed during 24 hour testing period0.10.20.50.4-0.40.4-0.3-0.20.4-0.70.20.40.3-0.5-0.50.6
Glucose0.50.71.1-0.90.9-0.91.01.0-1.00.2-0.6-0.9-0.80.70.7-1.1
Heart weight3.04.99.1-2.12.1-2.12.01.9-2.13.0-2.2-2.2-2.22.42.1-2.0
Delay discount hyperbolic model param1.92.510.6-1.41.4-1.41.40.4-1.33.2-1.5-1.4-1.31.61.5-1.0
Intermittent access intake day 1-15 change0.00.30.9-0.50.2-0.5-0.00.2-0.40.4-0.9-0.5-0.70.90.40.0
Intermittent access intake escalation0.10.51.3-0.70.3-0.70.20.3-0.60.7-1.0-0.7-0.81.10.6-0.1
Intermittent access intake escalation 20.30.51.4-0.70.4-0.80.20.5-0.70.4-1.1-0.8-0.91.20.7-0.2
Intermitt. access day 1 inactive lever presses0.00.63.20.7-0.50.7-0.4-0.40.6-1.80.90.70.7-0.8-0.6-0.0
Intermitt. access day 15 inactive lever presses0.52.95.61.8-1.41.8-1.7-1.31.7-2.41.91.71.8-1.8-1.61.1
Intermitt. access escalation Index0.20.71.9-0.91.4-0.91.11.2-0.90.4-0.6-0.7-0.70.50.3-0.7
Intermittent access day 1 total infusions1.33.86.71.9-1.71.9-1.7-1.41.8-2.62.32.02.0-2.3-2.11.3
Intermittent access day 15 total infusions0.40.92.20.9-1.00.9-1.2-0.90.9-1.50.90.90.8-0.8-0.90.7
Intermittent access terminal intake (last 3 days)1.01.83.01.3-1.31.3-1.5-1.11.2-1.71.41.31.3-1.3-1.41.0
Intermittent access total infusions1.41.73.81.3-1.31.3-1.4-1.11.2-2.01.51.21.2-1.3-1.30.8
Intermittent access day 1 locomotion1.22.14.11.5-1.21.5-1.1-0.81.4-2.01.71.51.5-1.7-1.51.0
Intermittent access day 15 total locomotion0.00.10.90.1-0.10.0-0.10.10.0-0.90.20.0-0.0-0.1-0.2-0.2
Intermittent access total locomotion0.10.21.40.2-0.10.2-0.10.10.1-1.20.40.20.2-0.4-0.4-0.1
Intermittent access standard deviation0.10.40.80.7-0.70.7-0.9-0.40.7-0.90.50.60.5-0.3-0.50.5
Left kidney weight0.00.10.20.2-0.30.2-0.4-0.40.1-0.40.20.20.1-0.2-0.20.2
Right kidney weight0.00.20.3-0.50.4-0.50.30.4-0.50.2-0.5-0.5-0.50.60.3-0.4
Cocaine induced anxiety0.00.10.30.3-0.10.3-0.2-0.10.3-0.50.40.30.4-0.5-0.20.0
Post-drug Anxiety1.21.42.3-1.21.3-1.21.41.4-1.20.4-1.0-1.2-1.10.91.2-1.5
Baseline Anxiety1.42.33.0-1.61.5-1.61.51.6-1.61.2-1.4-1.6-1.61.51.6-1.7
Tail length0.42.44.1-1.51.5-1.51.31.3-1.61.1-1.5-1.6-1.61.51.8-2.0
Length with tail1.88.210.1-2.92.7-2.92.72.7-3.01.8-3.0-3.0-3.02.93.1-3.2
Length without tail0.42.33.4-1.61.2-1.61.51.5-1.50.9-1.9-1.6-1.71.71.7-1.3
Times rat made contact with spout2.22.53.11.8-1.71.8-1.5-1.71.7-1.81.81.61.7-1.5-1.20.8
Lifetime Intake1.11.33.61.1-1.01.1-1.1-0.91.0-1.91.31.11.1-1.2-1.10.6
Liver weight, left3.76.48.6-2.62.6-2.52.82.6-2.62.0-2.3-2.6-2.42.42.5-2.9
Liver weight, right8.915.618.8-4.14.2-4.14.34.1-4.22.7-3.8-4.0-4.04.03.7-3.9
Locomotor activity0.10.21.30.3-0.10.30.1-0.00.2-1.20.30.30.3-0.4-0.1-0.1
Locomotor testing distance0.61.53.41.3-1.11.3-1.0-0.91.2-1.81.41.31.3-1.4-1.20.8
Locomotor testing rearing0.31.24.10.9-0.70.9-0.6-0.30.9-2.01.21.11.1-1.1-1.31.0
Locomotion in novel chamber0.81.12.5-1.01.1-1.11.10.8-1.01.6-1.1-1.0-1.00.91.0-0.9
Locomotion in novel chamber post-restriction1.03.04.0-1.81.8-1.81.82.0-1.91.0-1.7-1.8-1.81.61.7-1.7
Fecal boli incidents, locomotor time 10.30.71.40.9-0.90.9-0.9-1.20.90.20.90.80.8-0.8-0.90.7
Change in fecal boli incidents, locomotor task3.23.44.4-2.02.1-2.02.11.7-2.01.3-1.9-1.8-1.91.71.6-1.5
Time >=10cm from walls, locomotor time 10.20.20.70.3-0.30.3-0.3-0.70.3-0.80.20.40.2-0.1-0.50.8
Bouts of movement, locomotor time 12.93.85.32.1-2.32.1-2.2-1.82.1-1.21.91.92.0-1.8-1.91.7
Total resting periods, locomotor time 13.23.75.22.1-2.32.1-2.2-1.92.1-1.11.91.91.9-1.8-1.91.7
Rest time, locomotor task time 10.10.20.6-0.30.2-0.30.20.0-0.30.4-0.4-0.5-0.50.50.7-0.8
Distance moved, locomotor task time 10.20.62.0-0.81.1-0.81.01.4-0.80.5-0.6-0.7-0.60.60.3-0.5
Vertical activity count, locomotor time 10.00.30.6-0.60.5-0.60.50.8-0.60.2-0.7-0.6-0.60.70.5-0.4
Time >=10cm from walls, locomotor time 20.10.22.30.1-0.10.0-0.0-0.40.0-1.50.00.20.00.1-0.30.6
Bouts of movement, locomotor time 20.00.10.3-0.2-0.0-0.3-0.0-0.1-0.20.2-0.5-0.3-0.50.60.5-0.0
Total resting periods, locomotor time 20.00.10.2-0.0-0.2-0.1-0.2-0.4-0.00.2-0.3-0.1-0.30.40.30.2
Rest time, locomotor task time 21.11.93.01.4-1.51.4-1.5-1.71.4-0.91.41.31.3-1.3-1.31.2
Distance moved, locomotor task time 21.01.43.3-1.21.4-1.21.31.8-1.20.6-1.1-1.0-1.11.10.9-0.8
Vertical activity count, locomotor time 20.71.72.7-1.31.1-1.31.11.3-1.21.1-1.6-1.3-1.41.61.4-0.9
Light reinforcement 11.77.79.82.9-2.52.9-2.4-2.32.9-2.23.02.93.0-2.9-3.12.7
Light reinforcement 21.53.54.22.0-1.92.0-1.9-1.62.0-1.51.92.02.0-1.8-1.81.6
Bone: marrow area0.30.61.70.9-1.10.9-1.0-1.30.9-0.60.50.60.6-0.40.20.2
Bone: maximum diameter1.12.23.01.6-1.61.6-1.5-1.71.5-1.71.51.51.5-1.2-0.91.1
Bone: maximum force0.10.20.30.5-0.40.5-0.4-0.60.5-0.10.40.50.5-0.4-0.30.4
Bone: maximum moment0.10.20.50.6-0.50.6-0.5-0.70.6-0.10.40.50.5-0.5-0.30.4
Mean time between licks in bursts0.63.85.3-2.01.8-2.01.91.8-1.92.3-2.0-2.1-2.01.92.0-1.8
Mean num. licks in bursts0.00.10.20.4-0.30.4-0.4-0.40.4-0.00.20.30.30.0-0.00.1
Cd content in liver0.10.10.20.3-0.20.3-0.2-0.20.3-0.20.30.30.4-0.4-0.40.3
Co content in liver7.99.310.03.1-2.83.1-3.0-2.73.1-3.13.13.23.2-3.1-3.12.9
Cu content in liver0.20.30.80.5-0.30.6-0.4-0.70.4-0.90.60.50.6-0.6-0.1-0.1
Fe content in liver0.60.84.20.8-0.80.7-0.7-0.70.6-2.10.70.80.7-0.7-0.60.4
K content in liver0.20.20.50.3-0.50.3-0.6-0.70.30.2-0.0-0.1-0.00.20.7-0.6
Mg content in liver0.30.40.80.6-0.70.6-0.7-0.90.5-0.50.40.30.4-0.30.5-0.8
Mn content in liver0.00.00.40.1-0.10.1-0.1-0.20.10.7-0.0-0.00.00.10.10.0
Na content in liver0.20.20.60.4-0.60.4-0.5-0.80.3-0.10.10.10.1-0.10.6-0.5
Rb content in liver0.10.10.40.3-0.20.3-0.3-0.30.2-0.40.10.10.2-0.30.3-0.6
Se content in liver0.30.40.6-0.60.7-0.60.70.8-0.70.2-0.4-0.6-0.50.50.3-0.8
Sr content in liver0.40.41.1-0.40.2-0.40.3-0.1-0.41.1-0.7-0.6-0.60.71.0-0.6
Zn content in liver0.40.51.1-0.71.0-0.70.80.5-0.80.2-0.5-0.6-0.60.40.8-1.0
Bone: minimum diameter0.10.21.0-0.20.2-0.20.30.0-0.20.2-0.3-0.3-0.30.31.0-0.9
Time in familiar zone, hab. session 10.60.61.0-0.80.9-0.81.00.9-0.80.5-0.6-0.8-0.70.70.6-1.0
Time in novel zone, hab. session 10.50.61.3-0.80.9-0.80.80.8-0.81.1-0.8-0.7-0.70.70.6-0.3
Total zone transitions, hab. session 10.10.20.50.4-0.40.4-0.4-0.50.4-0.70.30.50.4-0.3-0.30.6
Total locomotion distance, hab. session 10.00.10.20.2-0.40.2-0.2-0.30.3-0.2-0.10.20.1-0.00.00.5
Locomotion velocity, hab. session 10.81.11.71.1-1.31.1-1.1-1.21.1-1.10.71.10.9-0.8-0.81.3
Time in familiar zone, hab. session 20.00.10.3-0.10.4-0.00.20.4-0.10.00.0-0.1-0.00.10.0-0.6
Time in novel zone, hab. session 20.20.20.4-0.60.4-0.60.40.4-0.50.4-0.6-0.5-0.60.60.50.1
Total zone transitions, hab. session 20.10.20.40.5-0.50.5-0.4-0.70.5-0.60.00.40.3-0.20.10.2
Total locomotion distance, hab. session 20.10.20.50.4-0.70.4-0.5-0.70.5-0.30.10.30.2-0.2-0.00.4
Locomotion velocity, hab. session 20.30.41.00.7-0.90.7-0.8-1.00.7-0.50.40.60.5-0.5-0.30.6
Novel to familiar place preference ratio0.30.40.9-0.70.5-0.70.40.1-0.61.0-0.8-0.5-0.70.60.50.3
Novelty place preference0.60.71.5-1.00.8-1.00.70.4-0.91.2-1.1-0.8-1.00.90.8-0.0
Time in novel zone, NPP test0.81.01.6-1.11.0-1.10.90.6-1.01.3-1.3-1.0-1.11.01.0-0.2
Total zone transitions, NPP test1.21.72.21.5-1.41.5-1.4-1.21.5-1.51.11.41.3-1.2-0.91.1
Total locomotion distance, NPP test1.31.92.61.5-1.61.5-1.6-1.41.5-1.40.91.41.2-1.1-0.91.5
Locomotion velocity, NPP test2.73.95.02.1-2.22.1-2.2-2.02.2-1.71.62.01.9-1.8-1.62.0
Intraocular pressure2.64.25.5-2.11.9-2.11.92.1-2.20.7-2.2-2.1-2.22.32.3-2.1
Delta distance traveled before/after self-admin2.12.33.5-1.61.8-1.61.91.8-1.61.5-1.2-1.4-1.41.21.1-1.4
Delta ambulatory time before/after self-admin0.20.41.5-0.60.8-0.60.91.2-0.60.2-0.3-0.4-0.40.20.0-0.5
Parametrial fat weight9.021.130.4-4.85.2-4.75.25.5-4.83.7-4.2-4.6-4.44.13.8-4.4
Pavlov. Cond. lever latency1.62.02.7-1.51.4-1.51.41.5-1.41.7-1.6-1.4-1.41.51.0-0.6
Pavlov. Cond. magazine entry latency0.00.10.10.3-0.30.3-0.3-0.30.2-0.10.20.10.2-0.20.2-0.4
Pavlov. Cond. change in total contacts0.10.10.60.2-0.20.2-0.1-0.10.1-0.50.1-0.00.0-0.00.5-0.8
Pavlov. Cond. index score0.50.60.80.9-0.90.9-0.9-0.90.8-0.90.90.70.8-0.9-0.40.0
Pavlov. Cond. latency score0.50.60.90.9-0.90.9-0.9-0.90.8-1.00.80.70.7-0.8-0.30.0
Pavlov. Cond. lever contacts0.91.11.41.2-1.21.2-1.1-1.21.1-1.11.21.01.1-1.1-0.50.2
Pavlov. Cond. magazine entry number0.20.20.4-0.60.7-0.60.60.6-0.50.3-0.4-0.4-0.40.40.1-0.0
Pavlov. Cond. intertrial magazine entries1.92.34.11.4-1.31.4-1.3-1.21.4-2.01.71.51.5-1.5-1.81.5
Pavlov. Cond. lever-magazine prob. diff.1.21.51.81.3-1.31.3-1.3-1.31.2-1.31.31.21.2-1.3-0.80.5
Pavlov. Cond. response bias0.81.01.41.1-1.21.1-1.1-1.21.1-0.81.00.91.0-1.0-0.60.3
Pavlov. Cond. lever latency1.11.61.9-1.31.4-1.31.31.3-1.30.9-1.3-1.2-1.31.21.4-1.2
Pavlov. Cond. magazine entry latency0.00.10.10.3-0.30.3-0.2-0.30.30.00.20.30.3-0.3-0.20.2
Pavlov. Cond. change in total contacts0.30.81.30.9-1.10.8-1.1-1.10.8-1.10.80.80.7-0.6-0.90.9
Pavlov. Cond. index score0.60.91.40.9-1.10.9-1.0-1.20.9-0.70.80.90.8-0.8-0.91.0
Pavlov. Cond. latency score0.50.81.10.9-1.10.9-1.0-1.10.9-0.80.80.90.8-0.7-0.91.0
Pavlov. Cond. lever contacts0.81.21.61.1-1.21.0-1.1-1.11.1-0.81.11.01.0-1.0-1.31.1
Pavlov. Cond. magazine entry number0.10.10.1-0.30.4-0.30.30.3-0.30.1-0.2-0.2-0.30.20.3-0.2
Pavlov. Cond. intertrial magazine entries1.53.34.7-1.92.0-1.91.82.0-1.92.2-1.7-1.8-1.81.71.4-1.4
Pavlov. Cond. lever-magazine prob. diff.0.30.50.80.7-0.90.6-0.8-0.90.7-0.40.50.60.6-0.5-0.70.8
Pavlov. Cond. response bias1.41.92.51.4-1.61.4-1.5-1.51.4-0.81.31.31.3-1.3-1.51.4
Time in closed arm before self-admin0.71.21.9-1.21.2-1.21.01.4-1.11.2-1.1-1.0-1.11.10.7-0.6
Time in closed arm after self-admin1.41.62.7-1.41.3-1.41.31.6-1.31.1-1.3-1.3-1.31.31.0-0.9
Time in open arm before self-admin0.20.20.60.5-0.80.5-0.5-0.70.5-0.60.30.30.3-0.20.00.1
Time in open arm after self-admin2.02.23.11.6-1.21.6-1.2-1.41.5-1.51.81.51.6-1.8-1.51.0
Bone: periosteal estimation0.61.42.81.4-1.51.4-1.4-1.71.4-1.11.01.21.1-0.8-0.40.8
Bone: periosteal perimeter0.30.61.10.8-0.90.8-0.8-1.00.9-0.70.70.70.7-0.5-0.20.5
Bone: post-yield work0.50.91.31.0-1.01.0-1.0-1.21.0-0.71.00.91.0-0.8-0.70.7
Progressive ratio test 1 active lever presses0.51.01.31.0-1.01.0-0.9-1.10.9-1.11.11.01.0-1.0-0.90.6
Progressive ratio test 1 breakpoint0.61.01.41.0-1.01.0-0.9-1.11.0-1.11.21.01.0-1.1-1.00.6
Progressive ratio test 1 inactive lever presses0.61.64.31.2-0.71.2-0.9-1.01.1-2.11.51.31.3-1.6-1.40.8
Progressive ratio test 2 active lever presses0.00.10.40.1-0.50.1-0.3-0.10.0-0.60.1-0.1-0.0-0.00.1-0.3
Progressive ratio test 2 breakpoint0.00.10.20.0-0.40.0-0.3-0.0-0.1-0.5-0.0-0.1-0.10.10.2-0.3
Progressive ratio test 2 inactive lever presses0.10.21.20.4-0.60.4-0.5-0.20.3-1.10.50.30.3-0.5-0.40.1
Incentive Sensitization - Responses0.00.10.40.1-0.60.1-0.5-0.10.1-0.1-0.1-0.0-0.10.2-0.00.2
Incentive Sensitization - Breakpoint0.00.00.2-0.1-0.4-0.1-0.30.1-0.1-0.0-0.3-0.2-0.20.30.10.1
Sum of active levers in priming session hrs 5-61.11.11.81.1-1.11.1-1.2-1.31.1-0.81.11.01.0-1.0-0.80.7
Progressive ratio0.51.51.8-1.31.4-1.31.21.2-1.31.0-1.3-1.2-1.31.41.2-1.0
Food seeking constrained by brief footshock1.72.12.91.5-1.31.4-1.5-1.51.4-1.21.51.51.4-1.5-1.71.4
Seeking ratio, punishment vs. effort0.92.12.71.4-1.41.4-1.4-1.41.4-1.31.51.41.4-1.5-1.71.4
Retroperitoneal fat weight19.487.1100.9-9.69.8-9.69.910.0-9.68.2-9.2-9.4-9.49.08.6-8.8
Reaction time number correct0.31.11.81.0-1.21.0-1.3-1.21.0-1.30.81.00.8-0.6-0.91.2
Reaction time mean minus median0.00.10.10.2-0.20.20.0-0.30.2-0.00.30.30.4-0.3-0.30.3
Reaction time mean minus median AUC0.00.00.1-0.00.00.00.20.0-0.0-0.20.00.10.1-0.1-0.10.2
Reaction time num false alarms0.20.40.80.7-0.60.7-0.6-0.50.6-0.30.80.60.7-0.8-0.90.4
Reaction time num false alarms AUC0.30.81.20.9-0.80.9-0.9-0.80.9-0.51.00.90.9-0.9-1.10.7
Reaction time trials correct on left0.31.11.81.0-1.21.0-1.3-1.21.0-1.30.81.00.8-0.6-0.91.2
Reaction time trials on left0.31.21.91.0-1.21.0-1.3-1.31.0-1.40.81.00.9-0.7-0.91.3
Reaction time mean0.30.81.4-0.91.1-0.91.21.0-1.00.6-0.5-0.8-0.70.40.6-1.2
Reaction time mean AUC0.20.61.2-0.81.1-0.81.10.9-0.90.5-0.4-0.6-0.50.20.5-1.0
Median of all reaction times0.61.01.9-1.01.3-1.01.31.2-1.10.5-0.5-0.9-0.80.40.7-1.4
Reaction time omissions0.10.10.20.3-0.20.3-0.00.10.3-0.40.40.40.4-0.3-0.50.4
Reaction time false alarm rate0.10.10.20.2-0.10.2-0.10.00.20.20.40.20.3-0.4-0.4-0.1
Reaction time premature initiation rate0.10.20.5-0.40.4-0.40.40.3-0.40.7-0.3-0.5-0.40.40.4-0.6
Reaction time premature initiations0.00.00.20.1-0.30.1-0.3-0.40.2-0.10.10.10.10.1-0.10.2
Std. dev. reaction times0.10.20.5-0.50.6-0.50.70.5-0.60.6-0.3-0.4-0.40.30.3-0.5
Reaction time trials completed0.31.21.91.0-1.21.0-1.3-1.31.0-1.40.81.00.9-0.7-0.91.3
Reaction time trials AUC0.41.52.41.2-1.31.1-1.5-1.41.1-1.50.91.21.0-0.8-1.01.4
Run reversals in cocaine runway, females0.10.11.10.0-0.30.0-0.3-0.50.11.0-0.1-0.0-0.00.0-0.30.4
Run reversals in cocaine runway, males0.50.61.00.7-0.70.7-1.0-0.90.8-0.30.60.70.6-0.6-0.71.0
Latency to leave start box in cocaine runway0.20.30.40.6-0.50.6-0.4-0.60.6-0.40.60.60.6-0.6-0.50.6
Latency to leave start box in cocaine runway, F0.20.30.40.6-0.50.6-0.6-0.60.6-0.20.50.60.6-0.5-0.30.5
Latency to leave start box in cocaine runway, M0.10.10.2-0.30.4-0.30.50.1-0.3-0.1-0.1-0.2-0.2-0.0-0.1-0.1
Std. dev. time between licks in bursts0.00.10.2-0.20.3-0.20.50.4-0.3-0.40.2-0.1-0.0-0.2-0.4-0.2
Total sessions with >9 infusions0.10.10.40.10.20.10.3-0.10.1-0.60.30.20.2-0.3-0.1-0.2
Short access day 1 total inactive lever presses3.06.19.42.5-2.12.5-2.2-2.32.4-3.12.62.62.5-2.6-2.52.1
Short access day 10 total inactive lever presses0.42.86.31.6-1.51.6-1.5-1.21.6-2.51.71.71.6-1.7-1.91.6
Short access day 1 total infusions0.51.02.50.9-0.50.9-0.4-0.50.9-1.61.31.01.1-1.3-1.30.6
Short access day 10 total infusions1.21.92.81.4-1.31.4-1.3-1.51.3-1.61.71.31.4-1.5-1.30.9
Short access total infusions0.10.21.20.3-0.00.3-0.0-0.00.2-1.10.50.30.3-0.4-0.4-0.2
Short access day 1 locomotion0.91.43.11.2-0.91.2-0.9-1.11.1-1.81.41.21.2-1.3-1.20.8
Short access day 10 total locomotion0.52.02.71.5-1.31.5-1.4-1.51.5-1.21.71.51.5-1.6-1.30.9
Short access total locomotion0.00.00.20.00.20.00.30.20.0-0.40.20.00.1-0.1-0.1-0.3
One hour access (0.3 mA shock)0.30.42.50.5-0.70.5-0.5-0.30.4-1.60.60.40.4-0.4-0.40.0
Compulsive drug intake0.30.40.9-0.70.7-0.71.00.8-0.6-0.1-0.6-0.5-0.60.70.4-0.2
One hour access (shock baseline)0.51.32.01.2-1.31.2-1.4-1.11.1-1.41.31.01.1-1.2-1.00.6
Social response proportion0.40.51.1-0.81.0-0.81.10.9-0.8-0.2-0.5-0.7-0.50.40.4-0.7
Social responses0.10.10.5-0.20.5-0.20.50.7-0.3-0.40.0-0.10.0-0.2-0.3-0.2
Social time0.60.91.6-1.01.1-1.01.31.2-1.00.5-0.8-0.9-0.80.60.7-1.0
Soleus weight5.817.019.04.3-4.14.4-4.2-4.04.3-3.24.34.34.3-4.1-3.94.0
Bone: stiffness0.00.00.00.1-0.10.1-0.1-0.20.1-0.00.10.00.1-0.1-0.0-0.1
Tibialis anterior weight4.515.518.94.1-3.84.1-3.9-3.64.1-2.54.24.14.2-4.3-4.03.9
Time to tail flick, vehicle, before self-admin0.81.04.2-1.01.0-0.90.60.7-1.02.1-0.9-0.9-0.90.80.8-0.7
Time to tail flick, vehicle, after self-admin1.53.14.8-1.71.8-1.71.51.4-1.82.2-1.8-1.7-1.71.81.9-1.8
Time to tail flick, test, before self-admin0.10.10.30.3-0.30.3-0.1-0.00.3-0.60.30.40.3-0.3-0.50.4
Time to tail flick, test, after self-admin0.20.20.40.4-0.60.4-0.5-0.70.40.40.30.30.3-0.3-0.20.4
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.2-0.0-0.20.1-0.0-0.20.2-0.5-0.3-0.20.50.7-0.5
Delta time to tail flick, test, before/after SA1.11.43.01.2-1.51.2-1.4-1.71.2-0.31.01.01.1-1.0-0.81.0
Tibia length3.18.610.9-3.03.1-3.03.02.9-3.11.6-3.0-3.0-3.02.83.1-3.3
Ambulatory time before self-admin0.10.20.90.3-0.50.2-0.4-0.60.3-1.00.10.20.10.00.10.2
Ambulatory time after self-admin0.50.81.4-0.91.1-0.91.21.2-1.00.1-0.7-0.8-0.80.70.5-0.8
Bone: tissue strength0.40.40.8-0.60.7-0.60.70.7-0.60.9-0.5-0.6-0.50.50.4-0.6
Total heroin consumption3.33.84.32.1-1.82.1-1.9-1.82.0-2.02.02.02.0-2.0-1.91.7
Bone: trabecular number3.56.68.32.6-2.32.6-2.2-2.42.5-2.82.82.72.7-2.9-2.52.2
Bone: trabecular spacing1.82.63.4-1.61.6-1.51.51.7-1.51.9-1.6-1.6-1.51.71.5-1.7
Bone: trabecular thickness0.60.81.20.9-0.90.9-0.7-0.90.9-0.31.00.91.0-1.1-0.80.8
Bone: trabecular tissue density0.20.30.40.5-0.60.5-0.6-0.60.5-0.30.60.40.5-0.6-0.70.4
Water consumed over 24 hours0.20.40.70.7-0.80.7-0.8-0.70.7-0.60.60.60.6-0.6-0.40.3
Number of responses in last shaping day0.30.41.4-0.50.3-0.50.40.2-0.5-0.2-0.7-0.6-0.60.71.2-1.0