Hub : Genes

Rab10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Rab10	0.04	0.04	2.2e-04	0.03	0.02	0.03	0.03	3.2e-04	2.2e-03	5.7e-04	8.1e-04
2	NAcc	gene expression	Rab10	0.06	0.05	8.3e-07	0.05	0.04	0.05	0.05	1.7e-06	2.3e-05	2.3e-06	2.0e-06
3	Adipose	gene expression	Rab10	0.06	0.06	6.8e-06	0.04	0.04	0.04	0.04	1.3e-05	2.7e-05	3.5e-05	2.9e-05
4	Adipose	mRNA stability	Rab10	0.08	0.06	5.6e-09	0.08	0.08	0.07	0.07	7.8e-09	5.5e-09	1.9e-08	1.5e-08
5	Brain	gene expression	Rab10	0.17	0.13	2.9e-14	0.15	0.15	0.15	0.15	1.4e-13	4.5e-14	8.9e-14	9.4e-14
6	BLA	gene expression	Rab10	0.1	0.09	2.0e-04	0.06	0.06	0.04	0.05	4.5e-04	5.5e-04	4.5e-03	1.0e-03
7	pVTA	gene expression	Rab10	0.09	0.09	1.6e-03	0.05	0.05	0.05	0.05	2.8e-03	3.7e-03	3.3e-03	3.3e-03
8	PL	gene expression	Rab10	0.08	0.06	3.1e-09	0.08	0.09	0.09	0.09	5.5e-09	9.2e-10	2.4e-10	1.3e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bone: apparent density	2.8	4.8	5.6	-2.4	-2.2	-2.1	2.2	2.2	-2.1	-2.2	-2.1
Area under the delay curve	0.0	0.0	0.2	-0.0	0.0	0.4	-0.2	-0.2	0.2	0.1	-0.2
BMI with tail	2.6	8.4	9.4	3.1	3.0	3.0	-2.9	-2.9	2.9	2.7	2.7
BMI without tail	0.5	1.1	1.4	1.2	1.0	1.0	-1.1	-1.1	1.0	0.7	1.1
Body weight	2.0	8.4	9.2	3.0	2.9	3.0	-2.9	-2.9	2.8	3.0	2.7
Weight adjusted by age	0.3	0.4	0.7	0.8	0.6	0.7	-0.6	-0.6	0.6	0.8	0.1
Bone surface	0.6	1.0	1.2	-1.0	-1.0	-1.0	1.0	1.0	-0.9	-0.9	-1.1
Bone volume	1.5	2.6	2.9	-1.7	-1.6	-1.6	1.6	1.6	-1.6	-1.5	-1.6
Breakpoint value in progressive ratio session	0.9	1.0	1.3	-1.0	-1.1	-0.9	1.1	1.0	-1.1	-1.0	-0.8
Number of licking bursts	1.3	1.5	1.8	1.3	1.2	1.2	-1.2	-1.2	1.2	1.2	0.9
Context. condit. distance diff. score	0.2	0.3	0.3	-0.6	-0.5	-0.5	0.5	0.5	-0.5	-0.4	-0.5
Locomotion velocity, session 1	0.8	0.9	1.3	1.1	0.9	0.8	-0.8	-0.9	0.9	1.1	1.1
Locomotion distance, session 1	0.2	0.3	0.4	-0.4	-0.6	-0.7	0.6	0.6	-0.6	-0.1	0.1
Locomotion velocity, session 2	0.0	0.0	0.1	0.2	0.1	0.1	-0.2	-0.2	0.1	0.4	-0.2
Locomotion distance, session 2	0.2	0.2	0.7	0.3	0.4	0.3	-0.3	-0.3	0.4	0.8	0.8
Locomotion velocity, session 3	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.1	0.2	-0.1	-0.1	-0.4
Locomotion distance, session 3	0.1	0.1	0.2	0.1	0.2	0.2	-0.2	-0.2	0.2	0.4	0.3
Stereotopy head waving bouts, day 3	2.1	2.5	3.2	-1.3	-1.6	-1.6	1.6	1.6	-1.6	-1.6	-1.8
Stereotopy head waving duration, day 3	0.7	0.8	1.8	-0.6	-0.9	-0.9	0.8	0.8	-0.9	-0.9	-1.3
Locomotion velocity, session 7	0.0	0.0	0.0	0.1	0.1	0.2	-0.1	-0.1	0.1	0.0	0.1
Locomotion distance, session 7	0.9	1.1	1.4	1.1	1.1	1.2	-1.0	-1.1	1.1	1.1	0.8
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.2	-0.0	-0.1	0.0	0.0	-0.0	0.0	-0.1
Stereotopy head waving duration, day 7	0.4	0.5	0.6	-0.6	-0.7	-0.7	0.7	0.7	-0.7	-0.7	-0.8
Locomotion velocity, session 8	0.5	0.6	0.7	-0.8	-0.8	-0.8	0.8	0.8	-0.8	-0.8	-0.7
Locomotion distance, session 8	0.2	0.3	0.4	-0.6	-0.6	-0.7	0.6	0.6	-0.6	-0.4	-0.3
Degree of sensitization distance	0.8	0.8	1.0	1.0	0.9	1.0	-0.9	-0.9	0.9	0.7	0.7
Degree of sensitization stereotypy	0.3	0.3	0.4	0.6	0.6	0.5	-0.5	-0.5	0.6	0.6	0.6
Conditioned locomotion	3.8	4.4	5.9	-2.0	-2.0	-1.9	2.1	2.1	-2.0	-2.3	-2.4
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.6	-0.4	-0.4	0.4	0.4	-0.4	-0.4	-0.6
Cocaine response after cond. not corrected	0.7	0.8	0.9	-0.9	-0.9	-0.9	0.9	0.9	-0.9	-0.9	-0.8
Cocaine response before conditioning	2.0	2.4	2.9	-1.5	-1.6	-1.7	1.6	1.6	-1.7	-1.6	-1.2
Saline control response	1.5	1.9	2.4	-1.5	-1.5	-1.3	1.5	1.4	-1.4	-0.9	-1.6
Bone: connectivity density	1.8	2.8	3.7	-1.9	-1.7	-1.7	1.7	1.7	-1.6	-1.6	-1.5
Bone: cortical apparent density	0.0	0.0	0.1	-0.3	-0.0	-0.0	0.1	0.1	-0.0	-0.3	0.2
Bone: cortical area	0.1	0.1	0.4	-0.1	0.2	0.2	-0.2	-0.2	0.2	0.6	0.0
Bone: cortical porosity	3.4	3.7	4.3	-1.8	-2.0	-1.9	2.0	2.0	-2.0	-1.7	-2.1
Bone: cortical porosity	2.7	2.9	3.3	-1.7	-1.7	-1.6	1.8	1.7	-1.7	-1.5	-1.8
Bone: cortical thickness	0.2	0.4	0.8	0.3	0.6	0.7	-0.7	-0.7	0.6	0.9	0.5
Bone: cortical thickness	0.4	0.5	0.8	-0.9	-0.7	-0.7	0.7	0.7	-0.7	-0.6	-0.6
Bone: cortical tissue density	0.0	0.0	0.1	-0.2	0.0	0.1	-0.0	-0.0	0.0	-0.2	0.3
Condit. Reinf. active minus inactive responses	2.0	2.3	2.6	1.5	1.5	1.5	-1.6	-1.6	1.5	1.4	1.6
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.1	1.2	1.3	1.3	-1.5	-1.4	1.3	1.1	1.3
Condit. Reinf. active responses	0.2	0.2	0.6	0.4	0.4	0.4	-0.5	-0.5	0.4	0.3	0.8
Condit. Reinf. inactive responses	0.8	1.0	1.3	-0.9	-1.1	-1.1	1.1	1.1	-1.1	-0.8	-0.5
Incentive salience index mean	0.2	0.3	0.4	0.5	0.5	0.5	-0.6	-0.5	0.5	0.5	0.6
Condit. Reinf. lever presses	0.5	0.6	0.8	-0.8	-0.8	-0.8	0.9	0.9	-0.8	-0.7	-0.6
Condit. Reinf. active minus inactive responses	1.1	1.4	1.6	-1.0	-1.2	-1.2	1.2	1.2	-1.2	-1.1	-1.1
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.7	-0.7	-0.8	-0.8	0.8	0.8	-0.8	-0.7	-0.7
Condit. Reinf. active responses	0.6	0.8	1.0	-0.7	-0.9	-0.9	1.0	1.0	-1.0	-0.9	-0.7
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.4	0.4	-0.5	-0.4	-0.2
Condit. Reinf. lever presses	0.9	1.3	1.5	-0.8	-1.1	-1.1	1.2	1.2	-1.2	-1.2	-1.2
Condit. Reinf. lever reinforcers received	0.5	0.7	0.9	-0.7	-0.9	-0.8	0.9	0.9	-0.9	-0.8	-0.6
Conditioned reinforcement - actives	4.3	4.3	6.3	-2.5	-2.0	-2.2	2.0	2.0	-1.9	-2.2	-1.8
Conditioned reinforcement - inactives	5.9	6.6	7.0	-2.6	-2.6	-2.5	2.6	2.5	-2.5	-2.6	-2.7
Conditioned locomotion	3.6	4.3	5.2	-2.3	-2.0	-2.2	2.1	2.1	-1.9	-2.1	-1.7
Patch foraging indifference point 0 sec	0.5	0.9	1.5	1.1	0.8	0.9	-0.9	-0.9	0.8	1.2	0.8
Patch foraging indifference point AUC	0.0	0.0	0.2	-0.1	0.0	0.1	0.1	0.1	0.0	0.0	-0.5
Delay disc. indifference point, 0s delay	1.1	1.2	1.6	1.1	1.3	1.3	-1.0	-1.1	1.2	1.2	0.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.3	-0.0	0.5	-0.3	-0.3	0.2	0.3	0.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.3	0.3	0.5	-0.3	-0.4	0.4	0.5	0.2
Delay disc. indifference point, 24s delay	2.5	2.4	2.7	-1.5	-1.6	-1.5	1.6	1.6	-1.6	-1.5	-1.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.3	0.5	0.6	-0.5	-0.5	0.5	0.4	0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.3	-0.1	0.0	0.1	0.1	-0.0	-0.3	-0.5
Indifference point function ln k	1.6	2.2	2.5	-1.4	-1.5	-1.5	1.5	1.5	-1.5	-1.6	-1.4
Indifference point function log k	1.6	2.2	2.5	-1.4	-1.5	-1.5	1.5	1.5	-1.5	-1.6	-1.4
Patch foraging total patch changes 0 sec	0.5	0.8	1.6	1.0	0.8	0.9	-0.8	-0.8	0.8	1.3	0.8
Patch foraging total patch changes 12 sec	0.9	1.2	1.7	1.2	1.1	1.2	-1.1	-1.1	1.1	1.3	0.8
Patch foraging total patch changes 18 sec	0.9	1.2	1.5	1.2	1.1	1.1	-1.0	-1.0	1.0	1.2	1.0
Patch foraging total patch changes 24 sec	1.2	1.5	2.0	1.4	1.2	1.2	-1.2	-1.2	1.2	1.3	1.1
Patch foraging total patch changes 6 sec	1.8	2.6	3.1	1.7	1.5	1.8	-1.6	-1.6	1.6	1.7	1.3
Patch foraging time to switch 0 sec	0.3	0.5	0.7	0.9	0.6	0.6	-0.7	-0.7	0.6	0.4	0.8
Patch foraging water rate 0 sec	1.0	1.7	2.0	-1.3	-1.3	-1.4	1.4	1.4	-1.3	-0.8	-1.2
Patch foraging water rate 12 sec	0.0	0.1	0.1	0.2	0.3	0.3	-0.3	-0.3	0.3	0.3	0.2
Patch foraging water rate 18 sec	1.0	1.4	1.6	-1.3	-1.2	-1.2	1.2	1.2	-1.3	-1.1	-0.9
Patch foraging water rate 24 sec	0.1	0.1	0.1	-0.0	0.4	0.4	-0.3	-0.3	0.3	0.4	0.2
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.4	0.4	-0.4	-0.2	-0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.3	0.1	-0.0	0.1	-0.0	-0.0	-0.0	0.3	-0.5
Distance traveled before self-admin	0.1	0.2	0.4	-0.3	-0.2	-0.4	0.3	0.3	-0.3	-0.7	-0.5
Distance traveled after self-admin	0.2	0.3	0.5	0.7	0.5	0.5	-0.4	-0.5	0.4	0.5	0.6
Extensor digitorum longus weight	2.0	7.9	10.0	-3.2	-2.9	-2.7	2.8	2.8	-2.8	-2.6	-2.6
Bone: elastic displacement	1.6	1.9	2.8	-1.7	-1.3	-1.4	1.3	1.3	-1.3	-1.5	-0.9
Bone: elastic work	0.5	0.6	1.1	-1.1	-0.8	-0.8	0.7	0.7	-0.8	-0.8	-0.6
Bone: endosteal estimation	0.1	0.1	0.2	-0.3	-0.4	-0.5	0.4	0.4	-0.4	-0.2	-0.4
Bone: endosteal perimeter	0.0	0.0	0.0	0.1	-0.1	-0.1	0.0	0.0	-0.1	0.2	-0.1
Epididymis fat weight	15.7	36.6	40.3	5.9	6.4	6.3	-6.2	-6.2	6.3	5.8	5.3
Delta time in closed arm before/after self-admin	0.3	0.3	0.9	0.5	0.4	0.5	-0.5	-0.5	0.3	1.0	-0.0
Delta time in open arm before/after self-admin	0.1	0.0	0.2	-0.3	-0.2	-0.2	0.2	0.2	-0.1	-0.4	0.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.2	-0.2	-0.1	0.2	0.2	-0.2	-0.1	-0.4
Delay discount exponential model param	0.0	0.0	0.1	0.2	0.2	-0.2	-0.0	0.0	0.0	0.1	0.4
Extinction: sum of active levers before priming	0.7	0.7	1.7	-0.8	-0.9	-0.7	0.8	0.8	-0.8	-0.5	-1.3
Active lever presses in extinction session 6	2.0	1.9	2.2	-1.4	-1.5	-1.2	1.4	1.3	-1.4	-1.4	-1.4
Bone: final force	0.0	0.0	0.1	-0.2	0.1	0.2	-0.1	-0.1	0.1	0.4	-0.3
Bone: final moment	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	-0.1	0.1	0.3	-0.2
Food consumed during 24 hour testing period	0.1	0.1	0.4	0.6	0.2	0.2	-0.2	-0.3	0.3	0.2	0.3
Glucose	0.2	0.4	0.6	0.8	0.6	0.5	-0.6	-0.6	0.6	0.4	0.6
Heart weight	4.5	6.4	7.1	2.2	2.7	2.6	-2.6	-2.6	2.6	2.5	2.5
Delay discount hyperbolic model param	0.0	0.0	0.1	0.2	0.1	-0.3	0.1	0.1	-0.1	0.0	0.3
Intermittent access intake day 1-15 change	1.9	1.9	2.8	-1.7	-1.3	-1.4	1.4	1.4	-1.4	-1.5	-0.8
Intermittent access intake escalation	1.1	1.1	1.7	-1.3	-0.9	-1.1	1.0	1.0	-1.0	-1.2	-0.5
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.2	0.3	0.3	-0.2	-0.2	0.2	0.1	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.3	0.3	-0.2	-0.3	-0.4
Intermitt. access day 15 inactive lever presses	1.8	2.0	3.0	-1.1	-1.5	-1.4	1.3	1.3	-1.4	-1.4	-1.7
Intermitt. access escalation Index	2.9	2.6	3.3	1.8	1.7	1.3	-1.6	-1.6	1.7	1.7	1.4
Intermittent access day 1 total infusions	4.2	4.9	7.0	-2.2	-2.3	-2.2	2.0	2.0	-2.1	-2.0	-2.6
Intermittent access day 15 total infusions	4.8	5.4	6.6	-2.6	-2.3	-2.4	2.2	2.2	-2.3	-2.2	-2.3
Intermittent access terminal intake (last 3 days)	4.0	4.4	5.1	-2.3	-2.1	-2.1	2.0	2.0	-2.1	-2.1	-2.2
Intermittent access total infusions	5.8	6.4	7.2	-2.7	-2.6	-2.6	2.4	2.4	-2.5	-2.5	-2.7
Intermittent access day 1 locomotion	2.5	2.6	3.3	-1.6	-1.6	-1.6	1.6	1.6	-1.5	-1.4	-1.8
Intermittent access day 15 total locomotion	0.6	0.7	1.5	-1.2	-0.7	-0.9	0.7	0.7	-0.6	-0.8	-0.8
Intermittent access total locomotion	1.1	1.3	2.2	-1.5	-1.0	-1.2	1.1	1.0	-1.0	-1.1	-1.0
Intermittent access standard deviation	0.8	0.8	1.4	-1.2	-0.8	-0.9	0.9	0.9	-0.8	-0.9	-0.9
Left kidney weight	0.6	1.6	2.5	-1.6	-1.2	-1.2	1.2	1.2	-1.2	-1.0	-1.4
Right kidney weight	0.1	0.2	0.4	0.0	0.5	0.5	-0.4	-0.4	0.5	0.6	0.3
Cocaine induced anxiety	0.0	0.0	0.1	-0.1	-0.2	-0.3	0.2	0.2	-0.2	-0.0	0.1
Post-drug Anxiety	1.5	1.7	2.4	1.3	1.2	1.2	-1.3	-1.2	1.2	1.4	1.5
Baseline Anxiety	1.4	1.5	1.8	1.3	1.2	1.3	-1.2	-1.2	1.2	1.1	1.2
Tail length	0.1	0.4	0.6	-0.6	-0.7	-0.8	0.6	0.6	-0.7	-0.7	-0.5
Length with tail	0.1	0.3	0.8	0.5	0.3	0.5	-0.5	-0.5	0.4	0.9	0.6
Length without tail	0.1	0.2	0.9	0.3	0.3	0.5	-0.3	-0.3	0.3	0.9	0.3
Times rat made contact with spout	0.5	0.5	0.7	-0.6	-0.8	-0.8	0.8	0.8	-0.7	-0.8	-0.5
Lifetime Intake	6.5	7.3	8.2	-2.9	-2.8	-2.8	2.6	2.6	-2.6	-2.6	-2.8
Liver weight, left	1.2	1.9	2.1	1.3	1.4	1.5	-1.3	-1.3	1.4	1.2	1.4
Liver weight, right	5.6	9.3	10.3	3.2	3.1	3.1	-3.0	-3.0	3.0	3.2	2.8
Locomotor activity	0.5	0.8	1.1	1.0	1.0	0.7	-0.9	-0.9	0.9	1.0	0.4
Locomotor testing distance	0.3	0.5	0.8	0.9	0.9	0.6	-0.8	-0.8	0.8	0.6	0.4
Locomotor testing rearing	0.4	0.7	1.5	-0.5	-0.8	-0.9	0.8	0.8	-0.8	-0.6	-1.2
Locomotion in novel chamber	0.3	0.4	0.5	0.6	0.7	0.6	-0.7	-0.7	0.7	0.6	0.5
Locomotion in novel chamber post-restriction	3.1	3.8	5.0	2.0	1.9	1.8	-1.8	-1.8	1.9	2.2	2.0
Fecal boli incidents, locomotor time 1	2.9	3.1	3.7	-1.9	-1.7	-1.8	1.9	1.8	-1.8	-1.6	-1.5
Change in fecal boli incidents, locomotor task	3.1	2.9	3.6	1.8	1.6	1.9	-1.8	-1.8	1.8	1.8	1.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.5	-0.6	-0.6	-0.7	0.7	0.7	-0.7	-0.7	-0.4
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.0	-0.0	0.1	0.0	0.0	-0.1	0.0	-0.2
Total resting periods, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	-0.2	-0.0	-0.1
Rest time, locomotor task time 1	0.0	0.0	0.0	0.0	0.1	-0.0	0.1	0.1	-0.0	-0.1	-0.0
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.6	0.1	0.4	-0.4	-0.4	0.4	0.4	0.4
Vertical activity count, locomotor time 1	0.2	0.2	0.5	0.5	0.3	0.5	-0.5	-0.5	0.4	0.4	0.7
Time >=10cm from walls, locomotor time 2	1.6	1.7	1.8	-1.3	-1.1	-1.3	1.4	1.3	-1.3	-1.3	-1.3
Bouts of movement, locomotor time 2	0.6	0.7	1.0	1.0	0.6	0.8	-0.8	-0.8	0.7	0.8	1.0
Total resting periods, locomotor time 2	0.8	0.8	1.2	1.1	0.7	0.9	-0.9	-0.9	0.8	0.9	1.0
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	0.2	-0.0	-0.1	-0.1	0.1	0.1	0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.2	0.2	-0.2	-0.3	-0.2
Vertical activity count, locomotor time 2	0.4	0.4	0.7	-0.5	-0.6	-0.5	0.6	0.6	-0.7	-0.6	-0.8
Light reinforcement 1	0.5	0.9	1.6	-0.6	-1.1	-1.0	0.9	1.0	-1.1	-0.4	-1.3
Light reinforcement 2	1.1	1.5	1.7	-1.0	-1.3	-1.2	1.3	1.3	-1.3	-1.0	-1.3
Bone: marrow area	0.1	0.2	0.2	-0.3	-0.4	-0.5	0.4	0.4	-0.4	-0.2	-0.4
Bone: maximum diameter	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.0	0.0	-0.1	0.3	0.0
Bone: maximum force	0.0	0.0	0.2	-0.1	0.1	0.2	-0.1	-0.1	0.1	0.4	-0.3
Bone: maximum moment	0.0	0.0	0.1	-0.1	-0.0	0.1	-0.1	-0.1	0.1	0.3	-0.3
Mean time between licks in bursts	1.8	2.5	3.2	1.8	1.6	1.5	-1.6	-1.6	1.6	1.5	1.6
Mean num. licks in bursts	1.4	1.7	1.9	-1.4	-1.4	-1.3	1.4	1.3	-1.3	-1.3	-0.9
Cd content in liver	0.4	0.4	0.7	0.6	0.5	0.5	-0.6	-0.6	0.5	0.7	0.9
Co content in liver	4.8	5.6	6.6	-2.2	-2.4	-2.5	2.3	2.4	-2.4	-2.6	-2.0
Cu content in liver	0.1	0.1	0.1	-0.4	-0.3	-0.4	0.3	0.3	-0.3	-0.2	0.0
Fe content in liver	0.1	0.1	0.3	-0.3	-0.4	-0.5	0.4	0.4	-0.4	0.1	-0.0
K content in liver	1.8	1.8	2.4	1.5	1.3	1.2	-1.3	-1.3	1.3	1.5	1.2
Mg content in liver	1.6	1.6	3.0	1.3	1.2	1.1	-1.3	-1.3	1.2	1.7	1.1
Mn content in liver	0.2	0.2	0.5	0.3	0.5	0.5	-0.5	-0.5	0.5	0.7	0.3
Na content in liver	1.9	2.0	2.6	-1.3	-1.4	-1.5	1.5	1.5	-1.4	-1.1	-1.6
Rb content in liver	0.5	0.6	1.1	1.0	0.6	0.7	-0.7	-0.7	0.6	0.8	0.8
Se content in liver	0.9	1.1	1.8	1.1	1.0	0.9	-1.0	-1.0	1.0	1.3	1.1
Sr content in liver	0.1	0.1	0.1	0.3	0.2	0.2	-0.2	-0.2	0.2	-0.0	0.3
Zn content in liver	1.4	1.6	2.3	1.4	1.2	1.1	-1.2	-1.2	1.2	1.5	1.2
Bone: minimum diameter	0.4	0.8	2.0	0.6	0.8	0.8	-0.9	-0.9	0.8	1.4	0.6
Time in familiar zone, hab. session 1	0.8	0.7	0.9	0.8	0.8	0.9	-0.9	-0.8	0.8	0.9	0.7
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.5	0.5	0.4	-0.5	-0.5	0.5	0.4	0.4
Total zone transitions, hab. session 1	0.1	0.1	0.3	-0.6	-0.4	-0.4	0.4	0.4	-0.4	-0.3	0.1
Total locomotion distance, hab. session 1	0.6	0.9	1.2	-1.1	-1.0	-0.9	1.0	1.0	-1.0	-1.0	-0.4
Locomotion velocity, hab. session 1	1.2	1.7	2.2	-1.5	-1.3	-1.3	1.3	1.3	-1.3	-1.5	-0.7
Time in familiar zone, hab. session 2	0.2	0.3	0.3	0.6	0.5	0.5	-0.5	-0.5	0.5	0.5	0.3
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	0.1	0.1	0.2
Total zone transitions, hab. session 2	0.4	0.5	1.3	0.6	0.6	0.5	-0.5	-0.5	0.6	0.9	1.1
Total locomotion distance, hab. session 2	0.4	0.5	1.5	0.6	0.6	0.5	-0.6	-0.6	0.6	0.6	1.2
Locomotion velocity, hab. session 2	0.2	0.3	1.2	0.4	0.4	0.4	-0.4	-0.4	0.4	0.4	1.1
Novel to familiar place preference ratio	0.5	0.5	0.8	0.9	0.7	0.7	-0.6	-0.6	0.7	0.9	0.5
Novelty place preference	0.8	0.8	1.2	1.1	0.9	0.9	-0.8	-0.9	0.9	1.1	0.7
Time in novel zone, NPP test	0.7	0.8	1.1	1.0	0.8	0.9	-0.8	-0.8	0.8	1.1	0.6
Total zone transitions, NPP test	0.6	0.9	1.2	-1.0	-1.0	-1.1	1.0	1.0	-1.0	-0.6	-0.5
Total locomotion distance, NPP test	1.0	1.3	1.6	-1.1	-1.2	-1.3	1.3	1.3	-1.2	-1.0	-0.7
Locomotion velocity, NPP test	1.3	1.9	2.2	-1.3	-1.5	-1.5	1.5	1.5	-1.5	-1.2	-0.9
Intraocular pressure	4.6	6.4	7.8	2.5	2.6	2.5	-2.4	-2.4	2.6	2.8	2.6
Delta distance traveled before/after self-admin	1.7	1.9	2.3	1.5	1.2	1.5	-1.3	-1.3	1.2	1.5	1.3
Delta ambulatory time before/after self-admin	0.4	0.5	0.7	0.8	0.5	0.7	-0.6	-0.6	0.5	0.9	0.8
Parametrial fat weight	9.1	17.8	19.4	4.2	4.3	4.3	-4.4	-4.4	4.3	4.2	3.6
Pavlov. Cond. lever latency	0.4	0.5	0.6	0.6	0.7	0.7	-0.8	-0.7	0.7	0.5	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.3	0.2	0.2	-0.2	-0.2	0.2	0.3	0.6
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.2	0.2	-0.2	0.1	-0.2
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.2	0.2	-0.2	0.0	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1	-0.0	0.2	0.1
Pavlov. Cond. lever contacts	0.3	0.4	0.5	-0.5	-0.6	-0.7	0.7	0.7	-0.6	-0.5	-0.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.0	0.0	-0.0	-0.1	-0.3
Pavlov. Cond. intertrial magazine entries	2.2	2.6	3.0	-1.6	-1.6	-1.6	1.6	1.6	-1.6	-1.7	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.5	-0.6	-0.7	0.7	0.7	-0.6	-0.5	-0.6
Pavlov. Cond. response bias	0.8	1.0	1.1	-0.9	-1.0	-1.0	1.1	1.1	-1.0	-1.0	-0.9
Pavlov. Cond. lever latency	0.8	1.1	1.5	0.7	0.9	1.0	-1.0	-1.0	1.0	1.2	1.2
Pavlov. Cond. magazine entry latency	0.0	0.1	0.3	0.5	0.2	0.1	-0.1	-0.1	0.1	-0.1	0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	0.0	-0.0	0.2	0.1	-0.1	-0.4	-0.3
Pavlov. Cond. index score	0.3	0.3	0.6	-0.2	-0.5	-0.5	0.6	0.6	-0.6	-0.8	-0.6
Pavlov. Cond. latency score	0.3	0.3	0.6	-0.2	-0.5	-0.5	0.6	0.6	-0.6	-0.8	-0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.5	-0.2	-0.4	-0.5	0.5	0.5	-0.5	-0.7	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.6	-0.4	-0.4	0.3	0.4	-0.3	-0.1	-0.2
Pavlov. Cond. intertrial magazine entries	2.6	3.4	4.5	1.7	1.7	1.7	-1.8	-1.8	1.8	2.0	2.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.1	-0.2	-0.2	0.3	0.3	-0.3	-0.5	-0.3
Pavlov. Cond. response bias	0.3	0.4	0.8	-0.4	-0.6	-0.6	0.7	0.6	-0.7	-0.9	-0.7
Time in closed arm before self-admin	0.2	0.2	0.5	0.5	0.6	0.5	-0.3	-0.3	0.4	0.2	0.7
Time in closed arm after self-admin	0.7	0.7	1.0	0.7	0.9	1.0	-0.8	-0.8	0.9	0.7	0.8
Time in open arm before self-admin	0.0	0.0	0.2	0.2	-0.1	0.1	-0.1	-0.1	-0.1	0.5	-0.1
Time in open arm after self-admin	0.2	0.2	0.5	-0.7	-0.5	-0.6	0.4	0.4	-0.4	-0.5	-0.2
Bone: periosteal estimation	0.1	0.2	0.3	-0.6	-0.5	-0.5	0.4	0.4	-0.4	-0.0	-0.5
Bone: periosteal perimeter	0.0	0.0	0.2	0.0	0.0	0.0	-0.1	-0.1	0.0	0.4	-0.1
Bone: post-yield work	2.0	2.7	3.1	-1.7	-1.6	-1.8	1.6	1.6	-1.6	-1.5	-1.7
Progressive ratio test 1 active lever presses	3.6	3.7	4.4	-2.0	-1.9	-2.1	1.8	1.8	-1.8	-1.9	-2.0
Progressive ratio test 1 breakpoint	2.7	2.8	3.6	-1.8	-1.6	-1.9	1.5	1.5	-1.6	-1.7	-1.7
Progressive ratio test 1 inactive lever presses	5.9	6.5	7.6	-2.5	-2.5	-2.7	2.4	2.4	-2.4	-2.6	-2.8
Progressive ratio test 2 active lever presses	2.7	3.0	3.5	-1.8	-1.9	-1.7	1.6	1.6	-1.7	-1.6	-1.8
Progressive ratio test 2 breakpoint	2.8	3.1	3.7	-1.9	-1.9	-1.7	1.7	1.7	-1.8	-1.7	-1.8
Progressive ratio test 2 inactive lever presses	3.5	4.1	4.7	-2.1	-2.2	-2.0	1.9	1.9	-2.0	-1.9	-2.1
Incentive Sensitization - Responses	1.7	1.7	2.3	-1.3	-1.5	-1.0	1.3	1.3	-1.4	-1.1	-1.4
Incentive Sensitization - Breakpoint	1.1	1.1	1.6	-1.0	-1.2	-0.8	1.1	1.1	-1.2	-0.8	-1.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.6	0.2	0.5	-0.3	-0.3	0.2	0.7	0.2
Progressive ratio	0.1	0.2	0.3	-0.2	-0.5	-0.4	0.5	0.5	-0.4	-0.3	-0.2
Food seeking constrained by brief footshock	14.7	18.1	19.8	-4.2	-4.5	-4.3	4.4	4.4	-4.4	-3.7	-4.1
Seeking ratio, punishment vs. effort	1.6	1.9	2.8	-1.7	-1.4	-1.3	1.3	1.3	-1.4	-1.2	-1.4
Retroperitoneal fat weight	29.3	96.1	101.8	9.6	10.1	10.0	-10.1	-10.1	10.0	9.7	8.8
Reaction time number correct	0.1	0.2	0.6	-0.8	-0.3	-0.4	0.4	0.4	-0.4	-0.5	-0.0
Reaction time mean minus median	0.0	0.0	0.2	0.1	0.2	-0.0	-0.1	-0.1	0.0	-0.4	0.1
Reaction time mean minus median AUC	0.1	0.1	0.2	0.3	0.4	0.2	-0.4	-0.3	0.3	-0.1	0.4
Reaction time num false alarms	1.8	2.4	3.9	1.9	1.4	1.4	-1.5	-1.4	1.4	2.0	1.3
Reaction time num false alarms AUC	1.9	2.6	4.0	2.0	1.5	1.4	-1.5	-1.5	1.4	2.0	1.4
Reaction time trials correct on left	0.1	0.2	0.6	-0.8	-0.3	-0.4	0.4	0.4	-0.4	-0.5	-0.0
Reaction time trials on left	0.1	0.2	0.6	-0.8	-0.3	-0.4	0.4	0.4	-0.3	-0.5	-0.0
Reaction time mean	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	-0.2	0.2	-0.1	0.2
Reaction time mean AUC	0.0	0.0	0.1	0.1	0.1	0.0	-0.1	-0.1	0.1	-0.2	0.1
Median of all reaction times	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	0.0	-0.2	-0.0
Reaction time omissions	0.2	0.2	0.4	0.4	0.5	0.4	-0.6	-0.6	0.5	0.4	0.6
Reaction time false alarm rate	2.3	3.2	5.2	2.3	1.7	1.6	-1.7	-1.7	1.6	2.1	1.4
Reaction time premature initiation rate	0.2	0.2	0.4	0.7	0.4	0.3	-0.4	-0.4	0.4	0.4	0.6
Reaction time premature initiations	0.0	0.0	0.2	0.2	0.2	0.0	-0.1	-0.1	0.2	0.1	0.4
Std. dev. reaction times	0.2	0.3	0.5	0.5	0.7	0.4	-0.6	-0.6	0.6	0.0	0.7
Reaction time trials completed	0.1	0.2	0.6	-0.8	-0.3	-0.4	0.4	0.4	-0.3	-0.5	-0.0
Reaction time trials AUC	0.2	0.2	0.6	-0.8	-0.4	-0.5	0.5	0.5	-0.4	-0.5	-0.1
Run reversals in cocaine runway, females	0.3	0.3	0.8	-0.6	-0.5	-0.5	0.6	0.6	-0.5	-0.9	-0.3
Run reversals in cocaine runway, males	1.1	1.0	1.6	-1.3	-1.0	-1.0	1.0	1.0	-1.0	-1.1	-0.7
Latency to leave start box in cocaine runway	0.6	0.7	1.4	-0.8	-0.7	-0.7	0.6	0.6	-0.7	-1.1	-1.2
Latency to leave start box in cocaine runway, F	0.2	0.2	0.7	-0.2	-0.4	-0.3	0.2	0.3	-0.4	-0.6	-0.8
Latency to leave start box in cocaine runway, M	2.1	2.0	2.7	-1.6	-1.2	-1.3	1.3	1.3	-1.2	-1.6	-1.6
Std. dev. time between licks in bursts	0.9	1.1	1.7	1.3	0.9	1.0	-1.0	-1.0	1.0	1.2	1.0
Total sessions with >9 infusions	7.1	7.8	9.0	-2.8	-2.8	-3.0	2.8	2.8	-2.8	-2.9	-2.5
Short access day 1 total inactive lever presses	3.1	3.5	5.5	-2.4	-1.6	-2.0	1.7	1.7	-1.6	-2.1	-1.7
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.2	0.3	0.4	-0.2	-0.3	0.3	0.2	-0.1
Short access day 1 total infusions	5.3	5.7	6.1	-2.5	-2.4	-2.5	2.2	2.3	-2.3	-2.5	-2.4
Short access day 10 total infusions	7.2	8.0	9.5	-3.0	-2.9	-2.8	2.7	2.7	-2.7	-2.8	-3.1
Short access total infusions	5.7	6.4	7.2	-2.6	-2.6	-2.7	2.4	2.4	-2.4	-2.5	-2.6
Short access day 1 locomotion	5.5	5.9	7.4	-2.4	-2.3	-2.7	2.4	2.4	-2.3	-2.7	-2.1
Short access day 10 total locomotion	1.3	1.4	1.7	-1.0	-1.1	-1.2	1.3	1.3	-1.2	-1.1	-1.2
Short access total locomotion	2.3	2.4	2.9	-1.6	-1.4	-1.7	1.6	1.6	-1.4	-1.7	-1.4
One hour access (0.3 mA shock)	2.4	2.8	5.0	-2.2	-1.6	-1.8	1.6	1.6	-1.6	-1.7	-1.2
Compulsive drug intake	3.7	3.8	4.8	1.8	2.2	1.8	-2.0	-2.0	2.1	1.7	1.9
One hour access (shock baseline)	6.6	7.6	9.2	-3.0	-2.9	-2.7	2.8	2.7	-2.8	-2.7	-2.5
Social response proportion	0.2	0.2	0.3	-0.6	-0.2	-0.5	0.3	0.3	-0.3	-0.5	-0.5
Social responses	0.1	0.1	0.3	0.2	0.5	0.4	-0.4	-0.4	0.4	0.5	-0.2
Social time	0.2	0.2	0.5	-0.6	-0.3	-0.5	0.3	0.3	-0.3	-0.3	-0.7
Soleus weight	2.4	7.1	9.1	-3.0	-2.7	-2.8	2.7	2.7	-2.7	-2.4	-2.3
Bone: stiffness	0.1	0.2	0.6	0.3	0.4	0.5	-0.4	-0.4	0.4	0.7	-0.1
Tibialis anterior weight	0.7	2.4	2.9	-1.7	-1.6	-1.6	1.6	1.6	-1.6	-1.1	-1.4
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.2	1.1	0.6	0.9	-0.6	-0.7	0.5	0.7	0.5
Time to tail flick, vehicle, after self-admin	5.9	6.4	7.7	2.1	2.8	2.6	-2.7	-2.7	2.7	1.9	2.5
Time to tail flick, test, before self-admin	1.0	1.0	1.5	-0.7	-1.0	-1.0	1.1	1.1	-1.1	-1.2	-0.6
Time to tail flick, test, after self-admin	1.0	1.0	1.1	-0.9	-1.0	-0.9	1.1	1.0	-1.0	-0.9	-1.1
Delta time to tail flick, vehicle, before/after SA	2.2	2.1	2.9	0.9	1.7	1.4	-1.6	-1.6	1.7	1.0	1.6
Delta time to tail flick, test, before/after SA	1.9	1.8	3.0	-1.4	-1.3	-1.3	1.3	1.3	-1.3	-1.1	-1.7
Tibia length	0.7	1.9	2.9	1.1	1.3	1.2	-1.5	-1.4	1.3	1.7	1.4
Ambulatory time before self-admin	0.1	0.1	0.4	-0.2	-0.2	-0.3	0.3	0.3	-0.2	-0.6	-0.4
Ambulatory time after self-admin	0.1	0.1	0.2	0.5	0.3	0.4	-0.3	-0.3	0.2	0.4	0.4
Bone: tissue strength	0.6	0.5	0.7	0.5	0.8	0.8	-0.8	-0.8	0.8	0.5	0.6
Total heroin consumption	1.3	1.6	1.9	-1.1	-1.4	-1.2	1.3	1.3	-1.4	-1.3	-1.0
Bone: trabecular number	3.3	5.1	5.6	-2.4	-2.3	-2.2	2.3	2.3	-2.3	-2.2	-2.2
Bone: trabecular spacing	0.9	1.1	1.5	1.1	1.0	1.0	-1.0	-1.0	1.0	1.2	1.0
Bone: trabecular thickness	0.4	0.5	0.6	-0.7	-0.7	-0.6	0.7	0.7	-0.7	-0.8	-0.8
Bone: trabecular tissue density	0.1	0.2	0.5	-0.4	-0.3	-0.4	0.4	0.4	-0.3	-0.7	-0.2
Water consumed over 24 hours	0.0	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.1	-0.1	-0.1
Number of responses in last shaping day	2.8	2.9	3.4	-1.7	-1.8	-1.5	1.7	1.7	-1.8	-1.7	-1.7