Rab10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA alternative polyA XM_063262358.1 0.07 0.08 7.3e-03 0.03 0.02 0.02 0.03 1.1e-02 4.5e-02 3.5e-02 1.2e-02
2 Brain gene expression Rab10 0.03 0.03 2.0e-03 0.02 0.02 0.02 0.02 6.6e-03 2.5e-03 6.5e-03 9.4e-03
3 Brain mRNA stability Rab10 0.05 0.05 3.5e-05 0.04 0.05 0.04 0.04 7.2e-05 3.0e-05 4.8e-05 5.6e-05
4 pVTA gene expression Rab10 0.06 0.05 1.4e-04 0.05 0.05 0.04 0.04 1.2e-04 6.8e-05 1.4e-04 1.6e-04
5 OFC gene expression Rab10 0.11 0.11 7.2e-03 0.02 0.04 0.01 0.03 8.7e-02 3.9e-02 2.2e-01 7.6e-02
6 PL gene expression Rab10 0.07 0.06 5.5e-08 0.07 0.07 0.07 0.07 4.2e-08 3.2e-08 5.9e-08 4.2e-08
7 Adipose mRNA stability Rab10 0.07 0.07 2.8e-06 0.05 0.05 0.05 0.05 1.7e-06 3.4e-06 6.4e-06 3.4e-06
8 BLA gene expression Rab10 0.06 0.06 6.2e-03 0.03 0.03 0.03 0.03 6.5e-03 8.3e-03 9.1e-03 8.2e-03
9 NAcc gene expression Rab10 0.03 0.04 2.4e-04 0.03 0.02 0.02 0.03 5.4e-05 4.1e-04 6.4e-04 8.1e-05
10 Adipose gene expression Rab10 0.04 0.05 6.4e-04 0.02 0.02 0.03 0.03 9.3e-04 1.2e-03 2.4e-04 7.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density2.23.74.82.22.0-2.02.02.02.01.91.92.01.5
Area under the delay curve0.10.11.40.00.1-0.10.10.10.10.20.20.1-1.2
BMI with tail1.86.37.0-2.5-2.62.6-2.6-2.6-2.6-2.6-2.6-2.5-1.9
BMI without tail2.16.48.3-2.9-2.52.5-2.5-2.5-2.5-2.5-2.5-2.5-2.4
Body weight1.87.89.1-2.6-3.03.0-3.0-3.0-3.0-3.0-2.9-2.9-0.4
Weight adjusted by age0.10.10.4-0.5-0.20.2-0.2-0.2-0.2-0.3-0.20.00.6
Bone surface0.30.61.20.80.8-0.70.70.70.70.70.70.81.1
Bone volume1.22.13.41.61.4-1.41.41.41.41.31.31.41.8
Breakpoint value in progressive ratio session0.60.71.00.90.9-0.90.90.90.91.01.00.9-0.1
Number of licking bursts1.21.93.2-1.6-1.31.3-1.3-1.3-1.3-1.3-1.3-1.3-1.8
Context. condit. distance diff. score0.30.40.70.40.6-0.60.60.60.60.70.60.50.8
Locomotion velocity, session 10.60.61.2-0.4-0.80.8-0.8-0.8-0.8-0.8-0.9-0.7-1.1
Locomotion distance, session 10.50.62.01.40.6-0.60.60.60.60.60.60.61.0
Locomotion velocity, session 20.10.11.0-0.4-0.20.2-0.2-0.2-0.2-0.2-0.2-0.21.0
Locomotion distance, session 20.10.20.90.4-0.30.3-0.3-0.3-0.3-0.3-0.3-0.30.9
Locomotion velocity, session 30.00.00.3-0.00.1-0.10.10.10.10.10.20.1-0.5
Locomotion distance, session 30.10.10.1-0.3-0.20.2-0.2-0.2-0.2-0.3-0.2-0.2-0.1
Stereotopy head waving bouts, day 32.12.52.71.51.6-1.61.61.61.61.61.61.51.5
Stereotopy head waving duration, day 30.60.71.10.50.8-0.80.80.80.80.90.90.71.1
Locomotion velocity, session 70.00.00.2-0.3-0.00.1-0.0-0.0-0.0-0.1-0.1-0.00.5
Locomotion distance, session 70.81.02.1-1.4-1.01.0-1.0-1.0-1.0-1.0-1.0-0.9-0.4
Stereotopy head waving bouts, day 70.10.11.0-0.1-0.10.1-0.1-0.1-0.1-0.1-0.1-0.01.0
Stereotopy head waving duration, day 70.30.40.50.60.7-0.70.70.70.70.60.70.70.6
Locomotion velocity, session 80.40.50.70.80.7-0.70.70.70.70.70.80.70.4
Locomotion distance, session 80.30.40.80.90.6-0.60.60.60.60.70.60.60.5
Degree of sensitization distance0.70.71.2-1.1-0.90.9-0.9-0.9-0.9-0.9-0.9-0.80.0
Degree of sensitization stereotypy0.30.30.3-0.5-0.60.6-0.6-0.6-0.6-0.6-0.6-0.60.5
Conditioned locomotion2.73.13.71.51.9-1.91.91.91.91.81.81.9-0.9
Cocaine response after cond. corrected0.10.10.20.30.4-0.40.40.40.40.40.40.40.2
Cocaine response after cond. not corrected0.60.70.80.80.9-0.90.90.90.80.80.90.80.7
Cocaine response before conditioning2.22.73.01.71.7-1.71.71.71.71.71.71.61.1
Saline control response1.21.62.11.51.3-1.31.31.31.31.21.21.31.3
Bone: connectivity density1.32.02.31.51.5-1.41.41.41.41.41.41.51.1
Bone: cortical apparent density0.10.10.50.50.2-0.20.20.20.20.30.20.1-0.7
Bone: cortical area0.10.11.0-0.1-0.20.2-0.2-0.2-0.2-0.1-0.2-0.21.0
Bone: cortical porosity3.43.74.11.91.9-1.91.91.92.01.91.92.01.7
Bone: cortical porosity2.93.23.81.91.8-1.81.81.81.81.71.81.91.5
Bone: cortical thickness0.20.40.4-0.5-0.60.6-0.6-0.6-0.6-0.6-0.6-0.7-0.3
Bone: cortical thickness0.30.30.70.90.6-0.50.50.60.60.60.50.6-0.3
Bone: cortical tissue density0.00.10.40.40.1-0.10.10.10.10.20.10.0-0.6
Condit. Reinf. active minus inactive responses2.02.32.9-1.5-1.61.6-1.6-1.6-1.6-1.4-1.5-1.7-1.1
Condit. Reinf. active-inactive response ratio1.92.02.6-1.6-1.51.4-1.4-1.4-1.4-1.3-1.3-1.6-1.0
Condit. Reinf. active responses0.20.20.7-0.1-0.50.4-0.5-0.5-0.5-0.3-0.4-0.6-0.8
Condit. Reinf. inactive responses1.11.33.01.71.1-1.11.11.11.11.11.01.10.8
Incentive salience index mean0.20.30.4-0.4-0.60.5-0.5-0.5-0.5-0.4-0.5-0.60.2
Condit. Reinf. lever presses1.11.64.71.21.1-1.11.11.11.11.11.01.12.2
Condit. Reinf. active minus inactive responses1.01.21.91.41.1-1.11.11.11.11.01.01.1-1.2
Condit. Reinf. active-inactive response ratio0.50.50.60.80.8-0.70.70.70.70.70.70.8-0.7
Condit. Reinf. active responses0.60.81.41.20.8-0.80.80.80.80.80.80.8-1.2
Condit. Reinf. inactive responses0.10.10.40.60.3-0.30.30.30.30.40.40.3-0.4
Condit. Reinf. lever presses0.91.21.31.11.2-1.11.21.11.11.11.11.2-0.6
Condit. Reinf. lever reinforcers received0.50.81.51.10.8-0.80.80.80.80.70.80.8-1.2
Conditioned reinforcement - actives3.15.26.32.52.5-2.52.52.42.42.42.32.20.3
Conditioned reinforcement - inactives4.36.38.02.82.7-2.62.62.62.62.62.62.60.4
Conditioned locomotion1.92.44.22.11.6-1.61.61.61.61.61.41.60.7
Patch foraging indifference point 0 sec0.61.13.7-0.9-0.91.0-1.0-0.9-0.9-0.9-0.9-0.81.9
Patch foraging indifference point AUC0.30.54.3-0.5-0.00.0-0.0-0.00.0-0.0-0.10.2-2.1
Delay disc. indifference point, 0s delay0.60.71.3-0.6-0.80.9-0.8-0.8-0.8-0.8-1.1-0.6-0.8
Delay disc. indifference point, 16s delay0.10.11.1-0.1-0.10.1-0.1-0.1-0.1-0.00.1-0.1-1.0
Delay disc. indifference point, 2s delay0.10.10.1-0.3-0.30.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3
Delay disc. indifference point, 24s delay2.12.43.31.81.6-1.61.61.61.61.61.61.60.9
Delay disc. indifference point, 4s delay0.20.21.2-0.2-0.30.3-0.3-0.3-0.3-0.2-0.3-0.2-1.1
Delay disc. indifference point, 8s delay0.00.10.3-0.00.2-0.20.20.20.20.20.20.2-0.6
Indifference point function ln k1.62.76.41.71.5-1.51.51.51.51.41.51.62.5
Indifference point function log k1.62.76.41.71.5-1.51.51.51.51.41.51.62.5
Patch foraging total patch changes 0 sec0.61.13.6-0.9-0.91.0-1.0-0.9-0.9-0.9-0.9-0.81.9
Patch foraging total patch changes 12 sec0.91.22.2-1.5-1.11.2-1.2-1.1-1.1-1.0-1.1-1.0-0.1
Patch foraging total patch changes 18 sec0.71.11.4-0.9-1.11.2-1.2-1.1-1.1-1.1-1.2-1.0-0.2
Patch foraging total patch changes 24 sec1.01.72.2-1.5-1.31.4-1.4-1.3-1.3-1.3-1.3-1.2-1.0
Patch foraging total patch changes 6 sec1.72.64.0-2.0-1.71.7-1.7-1.7-1.6-1.6-1.7-1.5-0.8
Patch foraging time to switch 0 sec0.20.50.8-0.8-0.70.7-0.7-0.7-0.7-0.6-0.6-0.90.1
Patch foraging water rate 0 sec1.02.13.81.81.3-1.31.31.31.31.21.31.42.0
Patch foraging water rate 12 sec0.00.10.1-0.1-0.30.3-0.3-0.3-0.3-0.3-0.2-0.3-0.4
Patch foraging water rate 18 sec1.01.52.91.51.1-1.11.11.11.11.01.21.01.7
Patch foraging water rate 24 sec0.10.10.3-0.2-0.40.4-0.4-0.4-0.4-0.6-0.4-0.30.1
Patch foraging water rate 6 sec0.20.30.70.80.5-0.50.50.50.50.40.50.50.7
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.6-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.1
Distance traveled before self-admin0.10.10.20.20.3-0.30.30.30.20.20.20.2-0.5
Distance traveled after self-admin0.81.01.3-1.0-1.01.0-1.0-1.0-1.0-1.2-1.1-0.9-0.5
Extensor digitorum longus weight2.07.910.63.22.9-2.92.92.92.92.92.92.90.7
Bone: elastic displacement1.31.52.21.51.3-1.31.31.31.21.21.31.2-0.3
Bone: elastic work0.40.60.80.90.7-0.70.70.70.70.80.80.6-0.7
Bone: endosteal estimation0.10.31.30.40.5-0.40.40.50.50.40.40.51.1
Bone: endosteal perimeter0.00.10.70.20.1-0.10.10.10.10.10.10.10.8
Epididymis fat weight15.151.558.8-7.7-7.57.5-7.5-7.5-7.5-7.5-7.4-7.4-3.6
Delta time in closed arm before/after self-admin0.10.10.4-0.5-0.20.2-0.2-0.2-0.1-0.1-0.1-0.10.7
Delta time in open arm before/after self-admin0.00.00.0-0.0-0.10.1-0.1-0.1-0.1-0.1-0.0-0.0-0.1
Diff in mean of infusions in LGA sessions0.10.10.4-0.7-0.30.3-0.3-0.3-0.3-0.2-0.2-0.10.4
Delay discount exponential model param0.20.20.9-0.3-0.30.3-0.3-0.3-0.3-0.4-0.4-0.31.0
Extinction: sum of active levers before priming0.70.82.30.40.8-0.80.80.80.80.91.00.81.5
Active lever presses in extinction session 62.12.12.51.51.4-1.41.41.41.51.51.61.61.1
Bone: final force0.00.00.1-0.2-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.3
Bone: final moment0.00.00.0-0.1-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.1
Food consumed during 24 hour testing period0.10.21.2-0.4-0.30.3-0.3-0.3-0.3-0.3-0.3-0.2-1.1
Glucose0.81.31.6-1.3-1.21.2-1.2-1.2-1.1-1.2-1.2-1.1-0.7
Heart weight1.11.62.2-1.5-1.31.3-1.3-1.3-1.3-1.3-1.3-1.30.8
Delay discount hyperbolic model param0.10.10.9-0.0-0.10.1-0.1-0.1-0.1-0.2-0.2-0.10.9
Intermittent access intake day 1-15 change0.40.92.01.40.9-0.90.90.90.90.80.90.80.7
Intermittent access intake escalation0.20.31.01.00.6-0.60.60.60.50.50.60.50.2
Intermittent access intake escalation 20.10.10.30.50.1-0.10.10.10.10.10.1-0.0-0.5
Intermitt. access day 1 inactive lever presses0.41.31.71.01.3-1.21.21.21.31.11.21.30.6
Intermitt. access day 15 inactive lever presses0.81.62.21.01.3-1.31.31.31.41.51.51.30.3
Intermitt. access escalation Index3.65.16.2-2.5-2.42.4-2.4-2.4-2.3-2.4-2.4-2.3-0.5
Intermittent access day 1 total infusions2.03.23.81.21.9-1.91.91.91.91.91.91.81.3
Intermittent access day 15 total infusions2.13.13.31.71.8-1.81.81.81.81.81.81.71.6
Intermittent access terminal intake (last 3 days)3.03.94.41.92.1-2.12.12.12.02.12.12.01.4
Intermittent access total infusions4.14.85.22.02.3-2.32.32.32.22.32.32.21.9
Intermittent access day 1 locomotion2.53.24.51.61.8-1.81.81.81.81.81.71.82.1
Intermittent access day 15 total locomotion0.00.10.10.30.3-0.30.30.30.20.30.20.1-0.1
Intermittent access total locomotion1.41.72.51.41.3-1.31.31.31.21.31.21.21.6
Intermittent access standard deviation1.02.13.01.61.4-1.41.41.41.41.41.31.31.7
Left kidney weight0.41.68.90.60.9-0.90.90.91.00.91.01.03.0
Right kidney weight0.10.64.3-0.6-0.30.3-0.3-0.3-0.3-0.3-0.3-0.32.1
Cocaine induced anxiety0.00.10.10.30.2-0.20.20.20.30.30.30.3-0.0
Post-drug Anxiety1.41.51.7-1.3-1.31.3-1.3-1.3-1.3-1.2-1.2-1.2-0.5
Baseline Anxiety3.23.74.1-1.9-2.02.0-2.0-2.0-2.0-2.0-2.0-2.0-1.2
Tail length0.00.11.10.00.1-0.10.10.10.10.10.20.11.0
Length with tail0.10.64.3-0.0-0.50.5-0.5-0.5-0.4-0.4-0.4-0.52.1
Length without tail0.41.110.80.70.1-0.10.00.10.20.10.20.23.3
Times rat made contact with spout0.50.60.70.90.8-0.80.80.80.80.70.70.80.4
Lifetime Intake4.45.45.92.12.4-2.42.42.42.32.32.42.32.1
Liver weight, left1.72.83.3-1.8-1.81.7-1.7-1.7-1.7-1.7-1.7-1.8-0.5
Liver weight, right2.74.75.6-2.2-2.32.3-2.3-2.3-2.3-2.4-2.3-2.2-0.3
Locomotor activity0.50.81.3-1.1-0.90.9-0.9-0.9-0.9-0.8-0.9-0.90.1
Locomotor testing distance0.30.51.0-1.0-0.70.7-0.7-0.7-0.7-0.6-0.7-0.8-0.4
Locomotor testing rearing0.30.51.00.40.7-0.70.70.70.70.80.70.71.0
Locomotion in novel chamber0.20.22.0-0.2-0.20.2-0.2-0.2-0.2-0.3-0.3-0.2-1.4
Locomotion in novel chamber post-restriction2.03.34.3-1.4-1.91.9-1.9-1.9-1.9-2.1-2.0-1.9-0.9
Fecal boli incidents, locomotor time 12.13.03.41.91.7-1.71.71.71.81.71.71.81.6
Change in fecal boli incidents, locomotor task3.43.34.1-2.0-1.91.9-1.9-1.9-1.9-1.9-1.7-1.8-1.3
Time >=10cm from walls, locomotor time 10.50.50.91.00.7-0.70.70.70.70.70.70.7-0.8
Bouts of movement, locomotor time 10.00.00.0-0.1-0.10.1-0.1-0.1-0.0-0.0-0.1-0.00.2
Total resting periods, locomotor time 10.00.00.00.0-0.00.1-0.1-0.0-0.0-0.00.0-0.00.0
Rest time, locomotor task time 10.20.30.4-0.7-0.50.5-0.5-0.5-0.5-0.4-0.6-0.5-0.5
Distance moved, locomotor task time 10.10.10.3-0.1-0.30.3-0.3-0.3-0.3-0.3-0.1-0.3-0.5
Vertical activity count, locomotor time 10.00.10.20.3-0.20.2-0.2-0.2-0.2-0.3-0.1-0.2-0.4
Time >=10cm from walls, locomotor time 21.21.82.21.31.4-1.41.41.41.41.41.31.5-0.1
Bouts of movement, locomotor time 20.20.40.5-0.5-0.70.7-0.7-0.7-0.7-0.7-0.5-0.7-0.1
Total resting periods, locomotor time 20.30.40.6-0.6-0.70.8-0.8-0.7-0.7-0.7-0.5-0.70.0
Rest time, locomotor task time 20.00.00.10.0-0.00.0-0.0-0.0-0.0-0.0-0.1-0.00.4
Distance moved, locomotor task time 20.10.11.20.00.0-0.10.10.10.10.10.00.1-1.1
Vertical activity count, locomotor time 20.10.10.20.20.4-0.40.40.40.40.40.40.4-0.3
Light reinforcement 10.92.213.30.90.9-1.00.91.01.01.11.10.93.7
Light reinforcement 21.01.52.21.51.2-1.21.21.21.21.11.21.30.9
Bone: marrow area0.10.31.20.40.5-0.40.40.40.40.40.40.51.1
Bone: maximum diameter0.10.32.50.10.0-0.00.00.00.00.00.00.01.6
Bone: maximum force0.00.00.10.10.1-0.10.10.10.10.10.10.10.4
Bone: maximum moment0.00.00.00.20.2-0.10.10.20.20.20.20.10.1
Mean time between licks in bursts0.71.82.0-1.2-1.41.4-1.4-1.4-1.4-1.4-1.4-1.3-1.2
Mean num. licks in bursts1.42.23.01.71.4-1.41.41.41.41.41.41.41.7
Cd content in liver0.30.32.5-0.2-0.20.2-0.2-0.2-0.2-0.1-0.1-0.41.6
Co content in liver5.26.16.82.62.5-2.52.52.52.52.62.62.32.2
Cu content in liver0.30.40.50.60.7-0.70.70.70.70.70.70.70.2
Fe content in liver1.82.22.91.71.5-1.51.51.51.51.51.51.51.0
K content in liver0.30.31.2-0.7-0.40.4-0.4-0.4-0.3-0.3-0.3-0.31.1
Mg content in liver1.11.111.2-0.10.1-0.00.00.10.10.10.10.13.4
Mn content in liver0.91.03.6-0.9-0.80.8-0.8-0.8-0.8-0.8-0.8-0.71.9
Na content in liver2.02.22.61.31.6-1.61.61.61.61.61.61.60.5
Rb content in liver0.30.32.2-0.4-0.30.3-0.3-0.3-0.3-0.2-0.2-0.31.5
Se content in liver0.20.21.0-0.1-0.30.3-0.3-0.3-0.3-0.4-0.4-0.21.0
Sr content in liver0.10.10.40.20.2-0.20.30.20.20.30.30.2-0.7
Zn content in liver0.60.62.4-0.7-0.70.7-0.7-0.7-0.7-0.6-0.6-0.61.6
Bone: minimum diameter0.50.91.4-1.2-0.90.9-0.9-0.9-0.9-0.8-0.9-0.90.9
Time in familiar zone, hab. session 10.80.71.2-1.1-0.80.8-0.8-0.8-0.8-0.9-0.8-0.80.8
Time in novel zone, hab. session 10.30.30.3-0.3-0.50.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Total zone transitions, hab. session 10.20.31.00.90.4-0.40.40.40.40.40.40.31.0
Total locomotion distance, hab. session 10.71.12.31.51.0-1.01.01.01.00.91.00.91.0
Locomotion velocity, hab. session 11.31.83.61.91.3-1.31.31.31.31.31.41.30.6
Time in familiar zone, hab. session 20.30.30.7-0.8-0.60.6-0.6-0.6-0.5-0.5-0.5-0.5-0.1
Time in novel zone, hab. session 20.00.00.00.2-0.10.1-0.1-0.1-0.1-0.1-0.1-0.1-0.0
Total zone transitions, hab. session 20.20.20.30.0-0.50.5-0.5-0.5-0.5-0.5-0.5-0.50.6
Total locomotion distance, hab. session 20.20.30.40.1-0.60.6-0.6-0.6-0.6-0.6-0.5-0.6-0.2
Locomotion velocity, hab. session 20.10.10.20.3-0.40.4-0.4-0.4-0.4-0.4-0.4-0.4-0.1
Novel to familiar place preference ratio0.40.51.5-0.3-0.60.6-0.6-0.6-0.6-0.7-0.7-0.51.2
Novelty place preference0.70.71.1-0.5-0.80.9-0.9-0.9-0.9-0.9-0.9-0.81.1
Time in novel zone, NPP test0.70.71.5-0.5-0.80.8-0.8-0.8-0.8-0.9-0.9-0.71.2
Total zone transitions, NPP test0.91.31.91.41.1-1.11.11.11.11.11.11.01.1
Total locomotion distance, NPP test1.31.73.21.81.3-1.31.31.31.31.21.31.31.1
Locomotion velocity, NPP test1.72.34.02.01.5-1.51.51.51.51.51.51.51.2
Intraocular pressure3.65.26.5-1.9-2.42.4-2.4-2.4-2.4-2.5-2.5-2.5-0.8
Delta distance traveled before/after self-admin2.12.32.8-1.7-1.51.6-1.6-1.6-1.5-1.5-1.5-1.4-1.2
Delta ambulatory time before/after self-admin0.40.50.6-0.7-0.80.8-0.8-0.8-0.7-0.7-0.7-0.60.1
Parametrial fat weight19.245.265.0-8.1-6.86.8-6.8-6.8-6.8-6.7-6.7-6.8-4.7
Pavlov. Cond. lever latency0.60.71.8-0.9-0.80.8-0.8-0.8-0.8-0.8-0.7-0.8-1.3
Pavlov. Cond. magazine entry latency0.10.11.10.3-0.10.1-0.1-0.1-0.1-0.0-0.1-0.11.0
Pavlov. Cond. change in total contacts0.10.10.80.10.2-0.20.20.20.20.30.20.20.9
Pavlov. Cond. index score0.30.32.60.50.3-0.30.30.30.30.30.20.31.6
Pavlov. Cond. latency score0.20.32.50.40.2-0.20.20.20.20.20.10.21.6
Pavlov. Cond. lever contacts0.70.82.30.90.8-0.80.80.80.80.80.70.81.5
Pavlov. Cond. magazine entry number0.10.11.0-0.5-0.20.1-0.1-0.1-0.2-0.2-0.1-0.1-1.0
Pavlov. Cond. intertrial magazine entries1.82.22.71.51.5-1.61.61.61.51.61.71.5-0.0
Pavlov. Cond. lever-magazine prob. diff.0.50.62.30.80.7-0.70.70.70.70.70.60.71.5
Pavlov. Cond. response bias0.81.01.81.01.0-1.01.01.01.01.00.91.01.3
Pavlov. Cond. lever latency0.50.71.5-0.5-0.80.8-0.8-0.8-0.8-0.8-0.8-0.91.2
Pavlov. Cond. magazine entry latency0.50.65.3-0.2-0.20.2-0.2-0.2-0.2-0.3-0.2-0.1-2.3
Pavlov. Cond. change in total contacts0.30.54.6-0.00.1-0.10.10.10.10.10.10.3-2.1
Pavlov. Cond. index score0.40.63.50.30.5-0.50.50.50.50.50.50.6-1.9
Pavlov. Cond. latency score0.50.63.60.30.6-0.60.60.60.60.50.50.7-1.9
Pavlov. Cond. lever contacts0.30.40.80.30.6-0.60.60.60.60.60.60.7-0.9
Pavlov. Cond. magazine entry number0.70.86.80.40.4-0.40.40.40.40.40.40.32.6
Pavlov. Cond. intertrial magazine entries1.92.93.5-1.5-1.81.8-1.8-1.8-1.8-1.7-1.7-1.90.4
Pavlov. Cond. lever-magazine prob. diff.0.40.54.50.00.2-0.20.20.20.20.10.20.3-2.1
Pavlov. Cond. response bias0.60.83.20.60.8-0.70.80.70.70.70.70.8-1.8
Time in closed arm before self-admin0.20.30.7-0.0-0.50.5-0.5-0.5-0.6-0.8-0.8-0.30.1
Time in closed arm after self-admin1.01.01.8-0.8-0.91.0-1.0-1.0-1.0-1.1-1.2-0.8-1.3
Time in open arm before self-admin0.10.10.4-0.20.0-0.00.00.10.10.30.3-0.10.6
Time in open arm after self-admin0.20.20.40.40.4-0.40.40.40.40.50.50.30.6
Bone: periosteal estimation0.20.53.00.50.5-0.50.50.50.50.50.50.51.7
Bone: periosteal perimeter0.10.11.10.10.1-0.10.10.10.10.10.10.11.1
Bone: post-yield work1.92.84.31.51.6-1.61.61.61.61.71.71.62.1
Progressive ratio test 1 active lever presses2.73.44.71.41.8-1.91.91.91.81.81.91.72.2
Progressive ratio test 1 breakpoint2.93.55.01.41.9-1.91.91.91.81.91.91.72.2
Progressive ratio test 1 inactive lever presses3.95.76.81.92.5-2.62.62.52.52.62.62.51.0
Progressive ratio test 2 active lever presses3.03.53.81.91.9-1.91.91.91.91.92.01.81.7
Progressive ratio test 2 breakpoint2.93.33.61.81.8-1.91.91.81.81.91.91.71.7
Progressive ratio test 2 inactive lever presses2.64.14.82.12.1-2.12.12.12.12.22.12.01.3
Incentive Sensitization - Responses2.13.03.71.81.7-1.71.71.71.71.81.81.71.9
Incentive Sensitization - Breakpoint1.82.43.21.51.5-1.51.51.51.51.61.51.51.8
Sum of active levers in priming session hrs 5-60.10.10.1-0.2-0.40.4-0.4-0.4-0.3-0.3-0.2-0.3-0.4
Progressive ratio0.00.00.10.1-0.10.2-0.2-0.1-0.1-0.1-0.2-0.10.2
Food seeking constrained by brief footshock14.517.819.64.14.2-4.24.14.24.24.34.24.24.4
Seeking ratio, punishment vs. effort1.42.12.51.21.5-1.51.51.51.51.51.61.51.2
Retroperitoneal fat weight32.1136.9166.0-12.9-12.112.1-12.1-12.1-12.0-11.9-11.9-12.0-6.9
Reaction time number correct0.10.31.01.00.5-0.50.50.50.50.40.40.50.1
Reaction time mean minus median0.20.54.4-0.3-0.20.2-0.2-0.2-0.2-0.2-0.1-0.3-2.1
Reaction time mean minus median AUC0.20.42.1-0.5-0.50.4-0.4-0.5-0.5-0.4-0.3-0.6-1.4
Reaction time num false alarms1.52.12.4-1.5-1.51.5-1.5-1.5-1.5-1.4-1.5-1.51.0
Reaction time num false alarms AUC1.52.32.5-1.5-1.61.6-1.6-1.6-1.5-1.5-1.6-1.51.1
Reaction time trials correct on left0.10.31.01.00.5-0.50.50.50.50.40.40.50.1
Reaction time trials on left0.10.21.01.00.5-0.40.40.40.40.40.40.40.1
Reaction time mean0.20.32.5-0.5-0.30.3-0.3-0.3-0.3-0.2-0.2-0.3-1.6
Reaction time mean AUC0.10.21.8-0.2-0.20.2-0.2-0.2-0.2-0.1-0.1-0.2-1.3
Median of all reaction times0.10.10.8-0.4-0.20.1-0.1-0.1-0.2-0.1-0.1-0.2-0.9
Reaction time omissions0.20.30.5-0.3-0.60.5-0.5-0.5-0.6-0.5-0.4-0.7-0.6
Reaction time false alarm rate2.02.83.8-1.9-1.71.8-1.8-1.7-1.7-1.7-1.7-1.70.7
Reaction time premature initiation rate0.10.10.30.2-0.40.4-0.4-0.4-0.4-0.3-0.4-0.40.5
Reaction time premature initiations0.10.10.50.7-0.10.1-0.1-0.1-0.1-0.1-0.1-0.10.6
Std. dev. reaction times0.61.17.0-0.6-0.60.6-0.6-0.6-0.7-0.6-0.6-0.7-2.7
Reaction time trials completed0.10.21.01.00.5-0.40.40.40.40.40.40.40.1
Reaction time trials AUC0.20.31.01.00.5-0.50.50.50.50.50.40.50.1
Run reversals in cocaine runway, females0.50.50.70.80.8-0.80.80.70.70.80.60.7-0.4
Run reversals in cocaine runway, males0.70.70.90.80.9-0.90.90.90.90.90.90.90.1
Latency to leave start box in cocaine runway0.40.40.7-0.00.7-0.80.80.70.70.80.80.6-0.2
Latency to leave start box in cocaine runway, F0.10.10.5-0.70.2-0.20.20.20.20.30.30.1-0.2
Latency to leave start box in cocaine runway, M0.60.60.70.70.8-0.80.80.80.80.80.80.8-0.1
Std. dev. time between licks in bursts0.70.91.2-0.6-1.01.0-1.0-1.0-1.0-1.1-1.1-0.9-0.3
Total sessions with >9 infusions2.42.94.31.91.7-1.71.71.71.61.51.61.52.1
Short access day 1 total inactive lever presses4.25.66.72.42.6-2.62.62.52.52.52.42.30.4
Short access day 10 total inactive lever presses0.40.91.20.61.1-1.11.11.11.11.11.01.1-0.2
Short access day 1 total infusions3.24.25.02.02.2-2.22.22.22.12.12.12.00.6
Short access day 10 total infusions3.95.05.61.82.3-2.42.42.32.32.22.32.22.0
Short access total infusions2.43.13.51.51.8-1.91.91.81.81.71.81.71.7
Short access day 1 locomotion2.02.53.61.91.7-1.71.71.71.61.51.61.5-0.1
Short access day 10 total locomotion1.32.44.11.51.5-1.51.51.51.51.41.41.52.0
Short access total locomotion1.31.52.31.51.3-1.21.21.21.21.11.11.21.3
One hour access (0.3 mA shock)2.52.84.52.11.7-1.81.81.71.71.61.71.61.0
Compulsive drug intake2.32.83.4-1.7-1.71.7-1.7-1.7-1.8-1.8-1.8-1.70.4
One hour access (shock baseline)4.26.48.12.92.7-2.62.62.62.62.62.72.60.6
Social response proportion0.10.10.50.30.2-0.20.20.20.10.20.20.00.7
Social responses0.30.41.9-0.5-0.50.5-0.5-0.5-0.5-0.5-0.4-0.61.4
Social time0.30.33.20.20.2-0.20.20.20.20.20.20.01.8
Soleus weight2.77.89.83.12.9-2.92.92.92.92.92.92.81.5
Bone: stiffness0.00.10.2-0.4-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.3
Tibialis anterior weight0.82.74.32.11.7-1.71.71.71.71.71.71.60.0
Time to tail flick, vehicle, before self-admin0.10.11.20.50.1-0.00.00.00.10.10.10.0-1.1
Time to tail flick, vehicle, after self-admin4.76.27.2-2.7-2.42.4-2.4-2.4-2.5-2.5-2.5-2.5-2.5
Time to tail flick, test, before self-admin0.30.31.00.90.5-0.40.40.40.40.40.30.4-1.0
Time to tail flick, test, after self-admin1.51.61.91.31.3-1.31.31.31.31.31.21.40.8
Delta time to tail flick, vehicle, before/after SA2.22.13.7-1.9-1.51.4-1.4-1.5-1.5-1.5-1.5-1.4-0.7
Delta time to tail flick, test, before/after SA2.72.73.21.31.7-1.71.71.71.71.61.61.81.7
Tibia length0.82.12.7-1.5-1.51.4-1.5-1.4-1.4-1.3-1.3-1.51.6
Ambulatory time before self-admin0.10.10.20.20.4-0.40.40.40.30.20.30.3-0.1
Ambulatory time after self-admin0.30.30.5-0.7-0.60.5-0.5-0.6-0.6-0.7-0.6-0.40.1
Bone: tissue strength0.90.93.3-0.8-0.80.8-0.8-0.8-0.8-0.8-0.8-0.8-1.8
Total heroin consumption2.12.54.22.01.6-1.61.61.61.61.61.71.60.4
Bone: trabecular number2.23.64.02.01.9-1.91.91.91.91.91.92.01.2
Bone: trabecular spacing0.60.81.1-1.0-0.90.9-0.9-0.9-0.9-0.8-0.9-1.00.7
Bone: trabecular thickness0.50.61.80.80.7-0.60.60.60.70.60.60.71.4
Bone: trabecular tissue density0.20.30.30.30.5-0.60.60.50.50.50.50.5-0.6
Water consumed over 24 hours0.40.52.2-0.6-0.50.6-0.6-0.6-0.6-0.7-0.6-0.5-1.5
Number of responses in last shaping day1.51.61.91.21.4-1.31.31.31.31.31.41.30.0