Hub : Genes

Agbl5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	XM_063262056.1	0.02	0.02	9.8e-03	0.01	0.01	0.01	0.01	1.5e-02	1.4e-02	1.4e-02	1.5e-02
2	pVTA	alternative TSS	NM_001126372.1	0.03	0.02	9.3e-03	0.01	0.01	0.01	0.01	2.1e-02	3.3e-02	1.1e-01	2.5e-02
3	Adipose	alternative TSS	XM_063262056.1	0.02	0.03	6.8e-03	0.01	0.01	0.01	0.01	8.7e-03	9.6e-03	1.2e-02	1.1e-02
4	pVTA	alternative TSS	NM_001126372.1	0.03	0.02	8.9e-03	0.02	0.01	0.02	0.01	1.8e-02	2.1e-02	1.1e-02	2.1e-02
5	NAcc	intron excision ratio	chr6_31208580_31208884	0.02	0.02	1.7e-03	0.01	0.02	0.02	0.01	6.7e-03	6.4e-04	3.0e-04	2.5e-03
6	NAcc	intron excision ratio	chr6_31207681_31208417	0.02	0.02	2.4e-03	0.01	0.02	0.01	0.01	9.4e-03	1.1e-03	1.1e-02	4.0e-03
7	RMTg	mRNA stability	Agbl5	0.13	0.1	6.7e-03	0.06	0.03	0.04	0.04	1.3e-02	4.6e-02	2.9e-02	2.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	2.8	4.8	6.3	2.4	1.7	1.7	2.5	2.4	-2.5	1.9
Area under the delay curve	0.0	0.0	0.1	0.2	0.1	0.1	0.3	0.1	-0.2	-0.2
BMI with tail	1.2	4.0	6.2	-2.1	-2.5	-2.5	-1.9	-1.7	1.8	-1.4
BMI without tail	1.4	4.1	4.8	-2.1	-2.2	-2.2	-1.9	-2.0	2.0	-1.9
Body weight	2.7	11.6	12.3	-3.5	-3.4	-3.4	-3.2	-3.5	3.4	-3.5
Weight adjusted by age	0.1	0.1	0.6	-0.2	-0.3	-0.3	0.0	0.4	-0.1	0.7
Bone surface	0.7	1.3	2.4	1.4	0.6	0.6	1.6	1.1	-1.4	0.9
Bone volume	1.2	2.1	3.3	1.7	1.1	1.1	1.8	1.5	-1.7	0.9
Breakpoint value in progressive ratio session	0.7	0.9	1.6	0.8	0.8	0.8	1.1	1.2	-1.1	0.5
Number of licking bursts	0.3	0.5	1.1	-0.6	-1.0	-1.0	-0.6	-0.5	0.6	-0.6
Context. condit. distance diff. score	0.1	0.1	0.3	0.3	0.5	0.4	0.3	0.3	-0.3	0.3
Locomotion velocity, session 1	0.4	0.4	0.7	-0.5	-0.7	-0.8	-0.6	-0.7	0.5	-0.8
Locomotion distance, session 1	0.4	0.5	0.9	0.9	0.4	0.3	0.9	0.6	-1.0	0.4
Locomotion velocity, session 2	0.2	0.2	0.4	-0.4	-0.3	-0.4	-0.5	-0.4	0.5	-0.6
Locomotion distance, session 2	0.1	0.2	0.4	-0.3	-0.5	-0.7	-0.3	-0.5	0.2	-0.5
Locomotion velocity, session 3	0.5	0.5	1.6	0.4	0.2	0.2	0.5	1.0	-0.7	1.3
Locomotion distance, session 3	0.1	0.1	0.2	0.1	-0.4	-0.5	0.3	0.3	-0.4	0.4
Stereotopy head waving bouts, day 3	2.5	2.9	3.5	1.7	1.6	1.6	1.7	1.8	-1.7	1.9
Stereotopy head waving duration, day 3	0.5	0.6	0.8	0.7	0.9	0.9	0.7	0.8	-0.8	0.8
Locomotion velocity, session 7	0.2	0.2	0.6	0.4	-0.0	-0.1	0.6	0.8	-0.6	0.3
Locomotion distance, session 7	0.5	0.6	1.4	-0.7	-1.1	-1.2	-0.4	-0.2	0.4	-1.0
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.2	-0.2	-0.3	-0.1	-0.1	0.0	0.5
Stereotopy head waving duration, day 7	0.5	0.7	1.9	0.6	0.6	0.6	0.7	0.7	-0.7	1.4
Locomotion velocity, session 8	0.4	0.5	0.6	0.8	0.8	0.6	0.8	0.6	-0.7	0.6
Locomotion distance, session 8	0.2	0.3	0.4	0.6	0.5	0.4	0.6	0.4	-0.6	0.3
Degree of sensitization distance	0.9	0.9	1.7	-0.9	-0.8	-0.9	-0.9	-0.9	1.0	-1.3
Degree of sensitization stereotypy	0.3	0.4	0.5	-0.7	-0.7	-0.7	-0.6	-0.6	0.6	0.0
Conditioned locomotion	4.1	4.7	5.1	2.2	2.3	2.3	2.1	2.1	-2.1	2.2
Cocaine response after cond. corrected	0.2	0.2	0.4	0.6	0.4	0.4	0.7	0.3	-0.6	0.1
Cocaine response after cond. not corrected	0.8	1.0	1.4	1.1	0.9	0.9	1.2	0.9	-1.1	0.8
Cocaine response before conditioning	2.8	3.3	4.3	1.8	1.8	1.8	1.6	1.9	-1.6	2.1
Saline control response	1.0	1.4	2.1	1.1	1.1	1.0	1.1	1.3	-1.1	1.4
Bone: connectivity density	2.1	3.3	4.6	1.9	1.3	1.2	2.2	2.0	-2.1	1.7
Bone: cortical apparent density	0.2	0.2	0.4	0.5	0.3	0.4	0.5	0.6	-0.5	0.4
Bone: cortical area	0.1	0.1	0.2	0.3	-0.3	-0.4	0.5	0.1	-0.3	-0.1
Bone: cortical porosity	2.1	2.2	3.1	1.4	1.4	1.5	1.4	1.5	-1.5	1.8
Bone: cortical porosity	1.8	2.0	2.2	1.4	1.3	1.4	1.5	1.3	-1.5	1.5
Bone: cortical thickness	0.1	0.2	0.4	-0.3	-0.6	-0.6	-0.4	-0.5	0.5	-0.5
Bone: cortical thickness	0.6	0.7	1.0	1.0	0.7	0.7	1.0	0.9	-0.9	0.6
Bone: cortical tissue density	0.1	0.1	0.3	0.4	0.2	0.3	0.4	0.5	-0.4	0.2
Condit. Reinf. active minus inactive responses	1.4	1.6	2.0	-1.3	-1.4	-1.3	-1.2	-1.0	1.2	-1.4
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.3	-1.2	-1.2	-1.1	-1.1	-1.0	1.1	-1.5
Condit. Reinf. active responses	0.0	0.0	0.1	0.0	-0.3	-0.2	0.0	0.1	0.0	-0.2
Condit. Reinf. inactive responses	1.0	1.3	1.7	1.2	1.0	0.9	1.3	1.1	-1.2	1.1
Incentive salience index mean	0.1	0.2	0.4	-0.3	-0.6	-0.5	-0.2	-0.2	0.2	-0.6
Condit. Reinf. lever presses	0.5	0.7	1.0	1.0	0.8	0.8	1.0	0.8	-1.0	0.4
Condit. Reinf. active minus inactive responses	2.7	3.6	8.8	1.6	1.4	1.4	1.6	1.9	-1.8	3.0
Condit. Reinf. active-inactive response ratio	1.2	1.4	5.0	0.9	0.8	0.8	0.8	1.1	-1.0	2.2
Condit. Reinf. active responses	1.9	2.6	5.5	1.4	1.1	1.1	1.5	1.7	-1.7	2.3
Condit. Reinf. inactive responses	0.5	0.7	1.2	0.9	0.5	0.5	1.0	1.0	-1.1	0.5
Condit. Reinf. lever presses	1.9	2.6	3.8	1.7	1.5	1.5	1.5	1.7	-1.5	2.0
Condit. Reinf. lever reinforcers received	1.8	2.5	5.6	1.4	1.1	1.1	1.4	1.7	-1.6	2.4
Conditioned reinforcement - actives	4.4	7.4	10.7	2.6	3.3	3.3	2.5	2.5	-2.5	2.3
Conditioned reinforcement - inactives	4.8	7.1	8.7	2.8	2.9	3.0	2.5	2.6	-2.5	2.3
Conditioned locomotion	1.6	2.1	3.2	1.3	1.8	1.8	1.2	1.3	-1.3	1.4
Patch foraging indifference point 0 sec	0.8	1.5	2.4	-1.3	-1.6	-1.5	-1.3	-0.9	1.0	-0.8
Patch foraging indifference point AUC	0.1	0.2	0.4	0.5	0.1	0.1	0.5	0.3	-0.6	0.4
Delay disc. indifference point, 0s delay	2.3	2.5	5.5	-1.4	-1.1	-1.1	-1.5	-1.6	1.7	-2.4
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.1	-0.0	-0.0	0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.4	-0.4	-0.4	-0.3	-0.4	0.4	-0.7
Delay disc. indifference point, 24s delay	1.5	1.6	2.1	1.4	1.5	1.5	1.3	1.1	-1.2	1.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	-0.1	-0.2	-0.2	-0.0	-0.2	0.1	-0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.2	0.3	0.3	0.2	0.2	-0.2	0.0
Indifference point function ln k	0.5	0.9	1.4	1.0	1.2	1.2	0.9	0.9	-0.8	0.7
Indifference point function log k	0.5	0.9	1.4	1.0	1.2	1.2	0.9	0.9	-0.8	0.7
Patch foraging total patch changes 0 sec	0.9	1.6	2.6	-1.4	-1.6	-1.6	-1.3	-1.0	1.1	-0.8
Patch foraging total patch changes 12 sec	1.6	2.1	2.4	-1.5	-1.5	-1.5	-1.5	-1.3	1.4	-1.4
Patch foraging total patch changes 18 sec	0.9	1.3	2.4	-1.2	-1.5	-1.5	-1.0	-0.9	0.9	-0.7
Patch foraging total patch changes 24 sec	1.1	1.9	2.2	-1.4	-1.5	-1.5	-1.5	-1.3	1.4	-0.9
Patch foraging total patch changes 6 sec	1.4	2.2	3.9	-1.6	-2.0	-1.9	-1.5	-1.0	1.1	-0.9
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.5	-0.6	-0.6	-0.3	-0.4	0.4	-0.1
Patch foraging water rate 0 sec	0.2	0.4	0.7	0.6	0.8	0.8	0.5	0.4	-0.6	0.6
Patch foraging water rate 12 sec	0.2	0.4	0.8	-0.6	-0.1	-0.0	-0.8	-0.9	0.9	-0.7
Patch foraging water rate 18 sec	0.2	0.2	0.8	0.4	0.9	0.9	0.2	-0.1	0.0	0.0
Patch foraging water rate 24 sec	0.5	0.7	1.2	-1.0	-0.4	-0.4	-1.1	-0.8	1.1	-0.9
Patch foraging water rate 6 sec	0.2	0.3	0.6	-0.3	0.3	0.3	-0.5	-0.8	0.6	-0.6
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.3	-0.5	-0.5	-0.2	-0.3	0.2	-0.1
Distance traveled before self-admin	0.1	0.2	0.5	0.4	0.7	0.7	0.2	-0.2	-0.1	0.0
Distance traveled after self-admin	1.5	1.9	3.3	-1.2	-0.8	-0.8	-1.4	-1.7	1.5	-1.8
Extensor digitorum longus weight	3.2	12.6	17.9	3.5	2.8	2.8	3.8	3.6	-3.8	4.2
Bone: elastic displacement	1.6	1.8	2.7	1.3	1.5	1.6	1.2	1.5	-1.2	0.9
Bone: elastic work	0.8	1.0	1.2	1.1	1.0	1.1	1.0	1.1	-1.0	0.6
Bone: endosteal estimation	0.2	0.4	1.0	0.7	0.4	0.3	1.0	0.5	-0.9	0.0
Bone: endosteal perimeter	0.0	0.1	0.3	0.3	0.1	0.0	0.5	0.2	-0.4	-0.2
Epididymis fat weight	17.4	59.5	66.7	-8.2	-7.5	-7.5	-7.8	-7.6	7.8	-7.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.4	-0.5	-0.5	-0.2	-0.3	0.2	0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.4	0.2	0.1	0.1	0.2	0.7	-0.3	0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.4	-0.5	-0.5	-0.2	0.1	0.0	-0.2
Delay discount exponential model param	0.2	0.2	0.3	-0.4	-0.4	-0.4	-0.6	-0.4	0.5	-0.1
Extinction: sum of active levers before priming	0.4	0.4	0.8	0.5	0.5	0.5	0.7	0.9	-0.7	0.5
Active lever presses in extinction session 6	1.4	1.3	2.0	1.1	1.2	1.2	1.2	1.4	-1.3	0.7
Bone: final force	0.0	0.0	0.1	0.0	-0.2	-0.3	0.2	0.1	-0.1	-0.3
Bone: final moment	0.0	0.0	0.1	0.1	-0.2	-0.2	0.2	0.0	-0.1	-0.4
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.1	-0.1	-0.2	0.1	0.2	-0.0	0.3
Glucose	0.7	1.0	1.6	-1.1	-1.3	-1.3	-0.9	-1.0	0.9	-0.5
Heart weight	2.2	3.5	5.3	-1.7	-1.4	-1.5	-1.8	-2.3	1.9	-2.2
Delay discount hyperbolic model param	0.0	0.1	0.1	-0.2	-0.1	-0.1	-0.4	-0.2	0.3	0.1
Intermittent access intake day 1-15 change	0.3	0.6	1.1	0.8	1.0	1.1	0.7	0.2	-0.6	0.7
Intermittent access intake escalation	0.1	0.2	0.5	0.5	0.7	0.7	0.3	-0.1	-0.3	0.4
Intermittent access intake escalation 2	0.0	0.1	0.2	0.2	0.1	0.2	0.2	-0.4	-0.0	0.3
Intermitt. access day 1 inactive lever presses	0.5	1.8	3.2	1.3	1.0	1.1	1.2	1.5	-1.3	1.8
Intermitt. access day 15 inactive lever presses	2.0	4.1	5.6	2.2	1.5	1.5	2.1	2.3	-2.1	2.4
Intermitt. access escalation Index	3.1	4.3	7.3	-2.0	-2.7	-2.7	-1.9	-1.8	1.7	-1.5
Intermittent access day 1 total infusions	3.9	6.3	6.9	2.5	2.6	2.6	2.4	2.6	-2.5	2.4
Intermittent access day 15 total infusions	2.5	3.7	4.8	2.0	2.2	2.2	1.8	1.6	-1.8	1.7
Intermittent access terminal intake (last 3 days)	3.9	5.1	6.8	2.3	2.6	2.6	2.1	1.9	-2.1	2.1
Intermittent access total infusions	5.1	6.0	8.0	2.4	2.8	2.8	2.3	2.3	-2.3	2.2
Intermittent access day 1 locomotion	2.7	3.4	3.7	1.8	1.9	1.9	1.7	1.9	-1.8	1.9
Intermittent access day 15 total locomotion	0.4	0.7	1.2	0.8	1.0	1.0	0.6	0.8	-0.7	1.1
Intermittent access total locomotion	1.6	1.9	2.9	1.2	1.7	1.7	1.2	1.3	-1.2	1.4
Intermittent access standard deviation	1.2	2.4	2.6	1.6	1.6	1.6	1.5	1.5	-1.6	1.5
Left kidney weight	0.0	0.1	0.1	0.2	0.4	0.4	0.3	-0.1	-0.2	-0.3
Right kidney weight	0.2	1.1	2.3	-1.0	-0.6	-0.7	-0.9	-1.4	1.1	-1.5
Cocaine induced anxiety	0.1	0.1	0.5	0.2	0.1	0.1	0.3	0.5	-0.4	0.7
Post-drug Anxiety	1.8	1.9	2.1	-1.4	-1.4	-1.4	-1.4	-1.4	1.4	-1.3
Baseline Anxiety	3.9	4.5	6.4	-2.0	-1.9	-1.9	-2.2	-2.2	2.1	-2.5
Tail length	0.2	0.7	2.4	-0.6	-0.2	-0.2	-0.6	-1.1	0.8	-1.5
Length with tail	0.8	3.5	6.7	-1.9	-1.1	-1.1	-1.8	-2.2	2.0	-2.6
Length without tail	0.3	1.1	2.1	-1.1	-0.9	-0.9	-0.8	-1.0	0.9	-1.4
Times rat made contact with spout	1.1	1.3	1.8	1.1	0.8	0.8	1.2	1.3	-1.2	1.3
Lifetime Intake	5.6	6.8	8.7	2.6	3.0	2.9	2.4	2.5	-2.4	2.2
Liver weight, left	3.0	5.0	7.6	-2.2	-1.9	-1.9	-2.2	-2.4	2.3	-2.8
Liver weight, right	6.0	10.4	13.5	-3.2	-2.5	-2.5	-3.5	-3.4	3.5	-3.7
Locomotor activity	0.5	0.8	1.0	-1.0	-1.0	-1.0	-0.9	-0.6	0.8	-1.0
Locomotor testing distance	0.1	0.1	0.4	-0.3	-0.6	-0.6	-0.2	0.2	-0.0	0.1
Locomotor testing rearing	0.5	1.0	2.3	0.7	0.5	0.5	0.9	1.5	-1.1	1.3
Locomotion in novel chamber	0.0	0.1	0.2	-0.4	-0.1	-0.1	-0.3	-0.3	0.2	-0.3
Locomotion in novel chamber post-restriction	2.9	4.7	5.7	-2.4	-2.2	-2.2	-2.3	-2.1	2.2	-1.7
Fecal boli incidents, locomotor time 1	0.9	1.3	2.2	1.3	1.5	1.5	1.0	0.6	-1.0	0.7
Change in fecal boli incidents, locomotor task	4.4	4.3	6.7	-2.1	-1.9	-1.9	-2.1	-1.9	2.1	-2.6
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	0.5	0.9	0.9	0.1	0.5	-0.1	-0.1
Bouts of movement, locomotor time 1	0.5	0.5	2.1	0.4	-0.3	-0.3	0.8	0.4	-0.7	1.5
Total resting periods, locomotor time 1	0.5	0.5	1.8	0.4	-0.2	-0.2	0.9	0.5	-0.8	1.3
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.4	-0.4	0.3	-0.5
Distance moved, locomotor task time 1	0.2	0.3	0.8	-0.5	-0.1	-0.1	-0.7	-0.5	0.8	-0.9
Vertical activity count, locomotor time 1	0.1	0.2	0.7	-0.3	-0.2	-0.2	-0.5	-0.4	0.5	-0.8
Time >=10cm from walls, locomotor time 2	0.9	1.4	2.3	1.2	1.5	1.5	1.2	0.8	-1.0	0.7
Bouts of movement, locomotor time 2	0.3	0.4	0.6	-0.6	-0.8	-0.8	-0.5	-0.8	0.6	0.2
Total resting periods, locomotor time 2	0.2	0.4	0.7	-0.6	-0.9	-0.9	-0.3	-0.6	0.4	0.5
Rest time, locomotor task time 2	0.2	0.2	0.6	0.3	-0.1	-0.1	0.5	0.3	-0.6	0.8
Distance moved, locomotor task time 2	0.2	0.2	0.8	-0.2	0.2	0.2	-0.4	-0.3	0.6	-0.9
Vertical activity count, locomotor time 2	0.1	0.1	0.5	0.0	0.4	0.4	-0.0	0.1	0.2	-0.7
Light reinforcement 1	0.8	2.0	4.0	1.3	0.3	0.3	1.8	1.5	-1.7	2.0
Light reinforcement 2	1.3	1.9	3.0	1.5	1.0	1.0	1.7	1.2	-1.5	1.6
Bone: marrow area	0.2	0.4	1.0	0.7	0.4	0.3	1.0	0.5	-0.9	0.1
Bone: maximum diameter	0.1	0.3	0.8	0.6	-0.0	-0.1	0.9	0.4	-0.8	0.2
Bone: maximum force	0.0	0.0	0.1	0.2	0.0	-0.0	0.3	0.3	-0.3	-0.0
Bone: maximum moment	0.0	0.1	0.2	0.4	0.1	0.1	0.4	0.3	-0.4	-0.0
Mean time between licks in bursts	1.2	2.9	3.8	-1.6	-1.3	-1.3	-1.9	-1.8	1.9	-2.0
Mean num. licks in bursts	0.6	1.0	1.4	1.0	1.2	1.1	0.9	0.9	-0.9	0.9
Cd content in liver	0.0	0.0	0.1	-0.2	-0.3	-0.3	-0.1	-0.3	0.0	0.0
Co content in liver	5.5	6.4	7.6	2.7	2.5	2.5	2.7	2.4	-2.6	2.1
Cu content in liver	0.4	0.4	0.7	0.7	0.8	0.8	0.5	0.7	-0.5	0.4
Fe content in liver	1.8	2.2	3.5	1.4	1.5	1.5	1.3	1.9	-1.6	1.0
K content in liver	0.2	0.2	0.6	-0.1	-0.4	-0.5	0.1	-0.3	-0.0	-0.8
Mg content in liver	0.2	0.2	0.5	-0.1	-0.5	-0.5	0.2	-0.2	-0.1	-0.7
Mn content in liver	0.7	0.8	1.9	-0.9	-1.4	-1.4	-0.5	-0.6	0.3	-0.6
Na content in liver	1.6	1.7	2.9	1.5	1.6	1.7	1.2	1.0	-1.1	0.6
Rb content in liver	0.2	0.2	0.4	-0.4	-0.6	-0.5	-0.2	-0.3	0.1	-0.6
Se content in liver	0.2	0.2	0.4	-0.6	-0.6	-0.6	-0.4	-0.3	0.3	0.0
Sr content in liver	0.1	0.1	0.3	0.2	0.6	0.6	-0.0	-0.3	0.1	-0.2
Zn content in liver	1.0	1.1	2.3	-1.0	-0.9	-0.9	-1.0	-1.0	1.0	-1.5
Bone: minimum diameter	0.4	0.8	1.6	-0.8	-1.0	-1.0	-0.6	-0.7	0.7	-1.2
Time in familiar zone, hab. session 1	1.1	1.1	1.8	-1.0	-1.1	-1.1	-0.8	-1.0	0.9	-1.3
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.6	-0.4	-0.4	-0.6	0.0	0.5	0.2
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.3	0.2	0.2	0.5	0.6	-0.4	0.3
Total locomotion distance, hab. session 1	0.4	0.6	0.9	0.8	1.0	0.9	0.8	0.6	-0.7	0.1
Locomotion velocity, hab. session 1	1.2	1.6	2.2	1.5	1.5	1.4	1.4	1.1	-1.2	0.7
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.4	-0.6	-0.6	-0.2	-0.1	0.3	0.1
Time in novel zone, hab. session 2	0.2	0.2	0.6	-0.3	-0.1	0.0	-0.4	-0.4	0.4	-0.8
Total zone transitions, hab. session 2	0.2	0.2	0.7	-0.4	-0.7	-0.9	-0.1	-0.4	0.2	-0.3
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.2	-0.6	-0.7	-0.1	-0.3	0.1	-0.0
Locomotion velocity, hab. session 2	0.0	0.1	0.2	-0.0	-0.4	-0.5	0.1	-0.1	-0.1	0.2
Novel to familiar place preference ratio	0.9	1.0	1.2	-1.0	-0.9	-0.9	-1.0	-1.1	1.0	-1.0
Novelty place preference	1.3	1.5	1.6	-1.3	-1.1	-1.1	-1.3	-1.3	1.3	-1.2
Time in novel zone, NPP test	1.4	1.5	1.7	-1.3	-1.1	-1.1	-1.3	-1.2	1.3	-1.2
Total zone transitions, NPP test	0.9	1.3	1.7	1.2	1.0	0.9	1.3	1.0	-1.3	1.2
Total locomotion distance, NPP test	1.4	1.9	2.3	1.4	1.2	1.1	1.5	1.3	-1.5	1.5
Locomotion velocity, NPP test	2.0	2.8	3.4	1.8	1.4	1.3	1.8	1.6	-1.8	1.8
Intraocular pressure	5.3	7.6	8.7	-2.9	-2.5	-2.5	-2.9	-2.7	2.9	-2.8
Delta distance traveled before/after self-admin	2.4	2.5	2.8	-1.5	-1.5	-1.5	-1.7	-1.6	1.6	-1.6
Delta ambulatory time before/after self-admin	0.6	0.8	1.0	-0.8	-1.0	-1.0	-0.8	-0.7	0.8	-1.0
Parametrial fat weight	16.5	38.9	43.2	-6.4	-6.3	-6.3	-6.3	-6.6	6.5	-5.3
Pavlov. Cond. lever latency	0.7	0.9	1.3	-1.0	-0.6	-0.6	-1.2	-1.0	1.1	-0.9
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.3	-0.4	0.0	0.1	-0.1	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	0.1	0.1	0.2	0.3	-0.2	-0.1
Pavlov. Cond. index score	0.1	0.2	0.3	0.4	-0.1	-0.1	0.6	0.5	-0.6	0.4
Pavlov. Cond. latency score	0.1	0.1	0.3	0.3	-0.2	-0.2	0.5	0.4	-0.5	0.4
Pavlov. Cond. lever contacts	0.5	0.6	1.0	0.9	0.5	0.5	1.0	0.8	-0.9	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	0.1	0.1	-0.4	-0.3	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	2.1	2.5	3.2	1.7	1.8	1.8	1.5	1.6	-1.5	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.0	0.8	0.4	0.4	1.0	1.0	-1.0	0.8
Pavlov. Cond. response bias	0.8	1.0	1.3	1.1	0.8	0.7	1.1	1.1	-1.1	0.9
Pavlov. Cond. lever latency	1.3	1.8	2.3	-1.4	-1.3	-1.2	-1.3	-1.4	1.2	-1.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.3	0.2	0.2	0.3	0.4	-0.2	0.5
Pavlov. Cond. change in total contacts	0.4	0.6	1.3	0.7	0.6	0.5	0.7	0.9	-0.7	1.1
Pavlov. Cond. index score	0.8	1.1	1.7	1.1	1.0	1.0	1.0	1.1	-1.0	1.3
Pavlov. Cond. latency score	0.9	1.2	1.8	1.1	1.0	1.0	1.0	1.1	-1.0	1.3
Pavlov. Cond. lever contacts	0.8	1.2	1.6	1.1	1.0	1.0	1.1	1.2	-1.0	1.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.1	-0.2	0.0	-0.3
Pavlov. Cond. intertrial magazine entries	3.3	5.0	5.9	-2.4	-2.1	-2.1	-2.3	-2.4	2.2	-2.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.9	0.8	0.6	0.6	0.7	0.8	-0.7	1.0
Pavlov. Cond. response bias	1.4	1.8	2.4	1.4	1.3	1.2	1.3	1.5	-1.2	1.5
Time in closed arm before self-admin	0.4	0.6	0.7	-0.8	-0.7	-0.7	-0.6	-0.9	0.7	-0.8
Time in closed arm after self-admin	0.8	0.9	1.2	-1.1	-0.9	-0.9	-0.9	-1.0	1.0	-0.7
Time in open arm before self-admin	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.0	-0.2	0.1	0.1
Time in open arm after self-admin	0.6	0.7	1.1	0.9	0.6	0.6	0.8	1.1	-1.0	0.9
Bone: periosteal estimation	0.2	0.5	1.3	0.9	0.4	0.3	1.1	0.6	-1.0	0.1
Bone: periosteal perimeter	0.1	0.1	0.3	0.4	0.1	0.0	0.6	0.2	-0.4	0.0
Bone: post-yield work	1.5	2.1	2.7	1.4	1.5	1.4	1.4	1.4	-1.5	1.6
Progressive ratio test 1 active lever presses	3.5	4.3	5.5	2.0	2.3	2.3	2.0	2.2	-1.9	1.6
Progressive ratio test 1 breakpoint	3.6	4.4	5.5	2.0	2.3	2.4	2.0	2.2	-1.9	1.6
Progressive ratio test 1 inactive lever presses	5.5	8.0	9.7	2.9	3.1	3.1	2.7	2.9	-2.6	2.5
Progressive ratio test 2 active lever presses	2.5	2.9	5.2	1.7	2.3	2.3	1.4	1.4	-1.4	1.1
Progressive ratio test 2 breakpoint	2.3	2.6	4.8	1.6	2.2	2.2	1.3	1.3	-1.3	1.0
Progressive ratio test 2 inactive lever presses	3.0	4.8	6.2	2.2	2.5	2.5	2.1	2.1	-2.0	2.0
Incentive Sensitization - Responses	0.8	1.1	2.2	1.2	1.5	1.4	0.9	0.7	-0.9	0.5
Incentive Sensitization - Breakpoint	0.6	0.8	1.6	1.0	1.3	1.2	0.6	0.5	-0.7	0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.2	-0.6	-0.6	-0.1	-0.1	0.0	-0.4
Progressive ratio	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.2	-0.2	0.1	-0.5
Food seeking constrained by brief footshock	8.1	10.0	11.8	3.1	3.4	3.4	3.0	3.4	-3.2	2.5
Seeking ratio, punishment vs. effort	1.1	1.6	2.0	1.3	1.4	1.4	1.1	1.4	-1.1	1.1
Retroperitoneal fat weight	30.5	130.3	141.8	-11.9	-11.8	-11.9	-11.5	-11.1	11.3	-10.3
Reaction time number correct	0.2	0.3	0.7	0.6	0.4	0.4	0.6	0.4	-0.7	0.8
Reaction time mean minus median	0.1	0.2	0.4	0.4	0.5	0.5	0.2	0.6	-0.1	0.5
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.1	0.0	0.0	-0.2	0.1	0.3	0.1
Reaction time num false alarms	1.4	1.9	4.1	-1.3	-2.0	-2.0	-1.1	-0.9	1.0	-0.8
Reaction time num false alarms AUC	1.3	2.0	4.2	-1.4	-2.1	-2.0	-1.2	-1.0	1.0	-0.8
Reaction time trials correct on left	0.2	0.3	0.7	0.6	0.4	0.4	0.6	0.4	-0.7	0.8
Reaction time trials on left	0.2	0.4	0.7	0.6	0.4	0.4	0.6	0.4	-0.7	0.9
Reaction time mean	0.3	0.4	1.3	-0.4	0.1	0.1	-0.6	-0.6	0.9	-1.2
Reaction time mean AUC	0.2	0.3	1.1	-0.3	0.2	0.1	-0.5	-0.5	0.8	-1.1
Median of all reaction times	0.4	0.6	1.9	-0.5	0.0	0.0	-0.7	-0.8	0.9	-1.4
Reaction time omissions	0.1	0.1	0.2	-0.1	-0.5	-0.5	0.0	0.2	-0.1	-0.0
Reaction time false alarm rate	1.8	2.5	4.3	-1.6	-2.1	-2.1	-1.4	-1.1	1.3	-1.2
Reaction time premature initiation rate	0.1	0.1	0.2	-0.5	-0.3	-0.4	-0.5	-0.2	0.4	-0.1
Reaction time premature initiations	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.1	-0.0	0.0	0.4
Std. dev. reaction times	0.0	0.1	0.3	-0.1	0.1	0.1	-0.4	-0.1	0.5	-0.5
Reaction time trials completed	0.2	0.4	0.7	0.6	0.4	0.4	0.6	0.4	-0.7	0.9
Reaction time trials AUC	0.3	0.5	1.1	0.7	0.5	0.5	0.7	0.5	-0.8	1.0
Run reversals in cocaine runway, females	0.2	0.2	0.7	0.5	0.8	0.8	0.2	0.2	-0.2	-0.0
Run reversals in cocaine runway, males	0.6	0.6	1.0	0.8	1.0	1.0	0.6	0.8	-0.6	0.5
Latency to leave start box in cocaine runway	0.8	0.9	1.2	1.0	1.1	1.1	1.0	0.9	-0.9	0.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	0.5	0.5	0.5	0.4	0.4	-0.4	0.0
Latency to leave start box in cocaine runway, M	0.6	0.6	1.0	0.8	1.0	1.0	0.7	0.6	-0.6	0.4
Std. dev. time between licks in bursts	0.7	0.9	1.3	-0.8	-1.1	-1.1	-0.8	-1.1	0.8	-0.9
Total sessions with >9 infusions	2.8	3.4	4.4	1.7	2.1	2.1	1.7	1.9	-1.7	1.5
Short access day 1 total inactive lever presses	8.0	10.5	12.1	3.5	3.2	3.2	3.2	3.3	-3.2	3.0
Short access day 10 total inactive lever presses	1.0	2.5	4.8	1.5	0.9	0.9	1.6	1.9	-1.7	2.2
Short access day 1 total infusions	5.9	7.8	9.5	2.8	2.9	2.8	2.7	3.1	-2.8	2.5
Short access day 10 total infusions	4.6	5.9	7.9	2.5	2.8	2.8	2.3	2.4	-2.3	1.8
Short access total infusions	3.2	4.1	5.5	2.0	2.3	2.3	1.9	2.0	-1.9	1.6
Short access day 1 locomotion	4.7	5.8	7.8	2.2	2.4	2.4	2.2	2.5	-2.2	2.8
Short access day 10 total locomotion	1.4	2.6	5.5	1.4	1.4	1.4	1.5	1.5	-1.5	2.3
Short access total locomotion	1.2	1.4	2.0	1.1	1.4	1.4	1.0	1.2	-1.0	1.3
One hour access (0.3 mA shock)	3.3	3.8	5.2	2.1	2.3	2.3	1.9	1.6	-1.8	1.5
Compulsive drug intake	2.6	3.1	4.1	-1.5	-2.0	-2.0	-1.6	-1.8	1.5	-1.7
One hour access (shock baseline)	4.5	6.8	9.8	2.6	3.1	3.1	2.5	2.2	-2.3	2.3
Social response proportion	0.1	0.1	0.6	0.0	0.3	0.3	-0.1	-0.3	0.1	-0.8
Social responses	0.3	0.4	0.8	-0.6	-0.6	-0.7	-0.4	-0.9	0.5	-0.6
Social time	0.1	0.1	0.3	-0.2	0.1	0.1	-0.2	-0.5	0.3	-0.4
Soleus weight	3.4	10.1	12.3	3.3	2.8	2.7	3.5	3.0	-3.4	3.3
Bone: stiffness	0.0	0.1	0.2	-0.2	-0.4	-0.4	-0.1	-0.1	0.1	0.2
Tibialis anterior weight	2.0	6.6	11.0	2.5	1.7	1.7	2.9	2.6	-2.9	3.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	-0.5	0.0	0.0	-0.7	-0.5	0.6	-0.2
Time to tail flick, vehicle, after self-admin	3.0	3.9	4.9	-2.1	-1.8	-1.8	-2.2	-1.9	2.1	-1.9
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.5	0.6	0.6	0.3	0.4	-0.3	0.5
Time to tail flick, test, after self-admin	0.6	0.6	1.1	0.8	1.0	1.0	0.8	0.4	-0.6	0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.2	-0.8	-1.1	-1.1	-0.6	-0.6	0.7	-0.8
Delta time to tail flick, test, before/after SA	1.8	1.8	2.3	1.5	1.5	1.5	1.5	1.1	-1.4	0.9
Tibia length	1.8	4.9	8.3	-2.1	-1.7	-1.7	-2.2	-2.4	2.3	-2.9
Ambulatory time before self-admin	0.1	0.2	0.4	0.4	0.7	0.7	0.4	-0.1	-0.2	0.3
Ambulatory time after self-admin	0.9	1.0	2.0	-0.8	-0.6	-0.6	-1.0	-1.3	1.1	-1.4
Bone: tissue strength	0.7	0.7	1.3	-0.8	-0.5	-0.5	-0.9	-1.1	0.9	-0.7
Total heroin consumption	2.5	2.9	3.4	1.8	1.5	1.5	1.8	1.8	-1.8	1.7
Bone: trabecular number	2.3	3.8	5.3	2.2	1.7	1.7	2.3	2.1	-2.2	1.3
Bone: trabecular spacing	1.4	1.9	2.9	-1.5	-1.0	-1.0	-1.7	-1.5	1.6	-1.2
Bone: trabecular thickness	0.3	0.4	0.7	0.8	0.5	0.5	0.8	0.7	-0.8	-0.0
Bone: trabecular tissue density	0.5	0.7	0.9	1.0	0.9	0.9	0.8	0.8	-0.7	0.9
Water consumed over 24 hours	0.0	0.1	0.2	0.1	-0.4	-0.4	0.2	0.1	-0.1	0.2
Number of responses in last shaping day	1.6	1.7	3.0	1.4	1.7	1.7	1.3	1.2	-1.0	0.5