Hub : Genes

Agbl5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr6_25487743_25488479	0.04	0.04	2.0e-03	0.02	0.02	0.01	0.02	5.0e-03	4.6e-03	2.0e-02	4.4e-03
2	NAcc	intron excision ratio	chr6_25488642_25488946	0.03	0.03	2.8e-03	0.01	0.01	0.01	0.01	5.9e-03	5.7e-03	2.1e-02	7.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	4.4	7.3	7.9	-2.8	2.6
Area under the delay curve	0.0	0.0	0.0	0.2	-0.2
BMI with tail	1.7	5.4	6.0	2.5	-2.2
BMI without tail	0.3	0.6	0.7	0.8	-0.7
Body weight	2.3	9.5	9.8	3.1	-3.0
Weight adjusted by age	0.2	0.2	0.3	0.5	-0.2
Bone surface	1.3	2.4	2.6	-1.6	1.4
Bone volume	2.2	3.8	4.4	-2.1	1.8
Breakpoint value in progressive ratio session	1.5	1.6	1.7	-1.3	1.3
Number of licking bursts	0.5	0.6	0.6	0.8	-0.8
Context. condit. distance diff. score	0.0	0.1	0.1	-0.3	0.2
Locomotion velocity, session 1	0.5	0.6	0.8	0.9	-0.6
Locomotion distance, session 1	0.4	0.6	0.8	-0.6	0.9
Locomotion velocity, session 2	0.2	0.2	0.2	0.5	-0.4
Locomotion distance, session 2	0.1	0.2	0.3	0.5	-0.2
Locomotion velocity, session 3	0.3	0.3	0.4	-0.4	0.7
Locomotion distance, session 3	0.1	0.1	0.1	-0.0	0.4
Stereotopy head waving bouts, day 3	2.3	2.7	2.8	-1.6	1.7
Stereotopy head waving duration, day 3	0.4	0.5	0.6	-0.7	0.7
Locomotion velocity, session 7	0.3	0.3	0.3	-0.5	0.5
Locomotion distance, session 7	0.2	0.3	0.3	0.5	-0.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.3	-0.1
Stereotopy head waving duration, day 7	0.4	0.5	0.6	-0.6	0.8
Locomotion velocity, session 8	0.5	0.6	0.7	-0.8	0.8
Locomotion distance, session 8	0.2	0.3	0.3	-0.6	0.5
Degree of sensitization distance	0.8	0.8	1.0	0.8	-1.0
Degree of sensitization stereotypy	0.4	0.4	0.5	0.7	-0.6
Conditioned locomotion	4.3	5.0	5.3	-2.3	2.2
Cocaine response after cond. corrected	0.3	0.3	0.3	-0.6	0.6
Cocaine response after cond. not corrected	1.1	1.2	1.2	-1.1	1.1
Cocaine response before conditioning	2.0	2.5	2.5	-1.6	1.6
Saline control response	0.9	1.2	1.4	-1.0	1.2
Bone: connectivity density	3.4	5.3	5.5	-2.3	2.3
Bone: cortical apparent density	0.2	0.2	0.3	-0.5	0.4
Bone: cortical area	0.0	0.0	0.0	-0.0	0.0
Bone: cortical porosity	3.0	3.2	3.4	-1.8	1.8
Bone: cortical porosity	2.4	2.6	2.8	-1.7	1.6
Bone: cortical thickness	0.2	0.4	0.4	0.5	-0.7
Bone: cortical thickness	0.8	0.9	0.9	-1.0	0.9
Bone: cortical tissue density	0.1	0.1	0.2	-0.4	0.3
Condit. Reinf. active minus inactive responses	1.4	1.6	1.8	1.3	-1.2
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.2	1.1	-1.0
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	-0.1
Condit. Reinf. inactive responses	1.0	1.1	1.3	-1.0	1.1
Incentive salience index mean	0.1	0.1	0.1	0.3	-0.2
Condit. Reinf. lever presses	0.4	0.6	0.6	-0.7	0.7
Condit. Reinf. active minus inactive responses	2.4	3.0	3.8	-1.5	2.0
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.0	-0.7	1.0
Condit. Reinf. active responses	1.8	2.5	3.2	-1.4	1.8
Condit. Reinf. inactive responses	0.9	1.1	1.2	-1.0	1.1
Condit. Reinf. lever presses	1.5	2.0	2.2	-1.4	1.5
Condit. Reinf. lever reinforcers received	1.6	2.2	2.9	-1.3	1.7
Conditioned reinforcement - actives	4.5	4.5	5.2	-2.3	1.9
Conditioned reinforcement - inactives	5.1	5.7	6.3	-2.5	2.3
Conditioned locomotion	2.6	3.1	3.3	-1.8	1.7
Patch foraging indifference point 0 sec	0.5	0.9	0.9	1.0	-0.9
Patch foraging indifference point AUC	0.6	0.7	0.7	-0.8	0.8
Delay disc. indifference point, 0s delay	2.9	3.1	3.3	1.7	-1.8
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.3	-0.1
Delay disc. indifference point, 2s delay	0.3	0.4	0.4	0.6	-0.6
Delay disc. indifference point, 24s delay	1.6	1.5	1.6	-1.3	1.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.4	-0.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.2	0.1
Indifference point function ln k	0.5	0.7	0.9	-1.0	0.7
Indifference point function log k	0.5	0.7	0.9	-1.0	0.7
Patch foraging total patch changes 0 sec	0.5	0.8	0.9	0.9	-0.9
Patch foraging total patch changes 12 sec	1.0	1.3	1.5	1.1	-1.2
Patch foraging total patch changes 18 sec	0.3	0.4	0.4	0.6	-0.7
Patch foraging total patch changes 24 sec	1.1	1.3	1.4	1.1	-1.2
Patch foraging total patch changes 6 sec	0.8	1.1	1.3	1.2	-1.0
Patch foraging time to switch 0 sec	0.1	0.2	0.4	0.6	-0.3
Patch foraging water rate 0 sec	0.4	0.6	0.8	-0.9	0.7
Patch foraging water rate 12 sec	0.4	0.7	0.9	0.7	-0.9
Patch foraging water rate 18 sec	0.1	0.1	0.1	-0.4	0.1
Patch foraging water rate 24 sec	0.6	0.8	1.0	0.8	-1.0
Patch foraging water rate 6 sec	0.2	0.3	0.4	0.4	-0.6
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.1	-0.0
Distance traveled before self-admin	0.1	0.1	0.1	-0.3	0.3
Distance traveled after self-admin	0.7	0.8	0.8	0.9	-0.9
Extensor digitorum longus weight	3.4	13.3	14.1	-3.5	3.8
Bone: elastic displacement	1.8	2.1	2.3	-1.5	1.3
Bone: elastic work	0.9	1.1	1.2	-1.1	1.0
Bone: endosteal estimation	0.2	0.4	0.4	-0.6	0.6
Bone: endosteal perimeter	0.0	0.0	0.0	-0.2	0.2
Epididymis fat weight	15.5	36.2	36.7	6.0	-6.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	0.6	-0.5
Delta time in open arm before/after self-admin	0.2	0.2	0.3	-0.4	0.5
Diff in mean of infusions in LGA sessions	0.2	0.2	0.3	-0.5	0.4
Delay discount exponential model param	0.0	0.0	0.0	0.1	-0.1
Extinction: sum of active levers before priming	0.3	0.3	0.4	-0.5	0.6
Active lever presses in extinction session 6	1.7	1.6	1.6	-1.3	1.3
Bone: final force	0.0	0.0	0.0	-0.1	0.0
Bone: final moment	0.0	0.0	0.0	-0.2	0.1
Food consumed during 24 hour testing period	0.0	0.0	0.0	0.0	-0.1
Glucose	0.2	0.3	0.3	0.5	-0.6
Heart weight	7.3	10.4	11.1	3.1	-3.3
Delay discount hyperbolic model param	0.0	0.0	0.0	0.0	-0.1
Intermittent access intake day 1-15 change	0.8	0.8	0.9	-1.0	0.8
Intermittent access intake escalation	0.3	0.3	0.4	-0.6	0.5
Intermittent access intake escalation 2	0.2	0.2	0.3	0.5	-0.4
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.2	-0.5	0.3
Intermitt. access day 15 inactive lever presses	5.1	5.6	5.7	-2.4	2.3
Intermitt. access escalation Index	1.8	1.6	2.1	1.4	-1.1
Intermittent access day 1 total infusions	5.6	6.5	6.7	-2.6	2.5
Intermittent access day 15 total infusions	4.0	4.4	4.8	-2.2	2.0
Intermittent access terminal intake (last 3 days)	3.5	3.8	4.2	-2.0	1.9
Intermittent access total infusions	4.9	5.4	6.0	-2.4	2.2
Intermittent access day 1 locomotion	2.7	2.8	3.0	-1.7	1.6
Intermittent access day 15 total locomotion	1.0	1.0	1.2	-1.1	0.9
Intermittent access total locomotion	1.0	1.2	1.3	-1.1	1.0
Intermittent access standard deviation	0.6	0.6	0.6	-0.8	0.8
Left kidney weight	0.1	0.3	0.4	-0.6	0.4
Right kidney weight	0.6	1.6	1.8	1.2	-1.3
Cocaine induced anxiety	0.2	0.2	0.2	-0.4	0.4
Post-drug Anxiety	1.7	1.8	1.8	1.4	-1.4
Baseline Anxiety	2.1	2.2	2.3	1.5	-1.5
Tail length	0.0	0.1	0.2	-0.4	0.1
Length with tail	0.6	2.1	2.4	1.3	-1.6
Length without tail	0.5	1.1	1.1	1.0	-1.0
Times rat made contact with spout	1.3	1.5	1.8	-1.3	1.1
Lifetime Intake	6.2	7.0	7.6	-2.8	2.5
Liver weight, left	1.3	2.1	2.2	1.4	-1.5
Liver weight, right	8.8	14.6	14.6	3.8	-3.8
Locomotor activity	0.6	0.9	0.9	1.0	-0.9
Locomotor testing distance	0.0	0.1	0.1	0.4	-0.1
Locomotor testing rearing	0.6	1.0	1.4	-0.8	1.2
Locomotion in novel chamber	0.4	0.5	0.6	0.6	-0.8
Locomotion in novel chamber post-restriction	3.2	3.9	4.4	2.1	-1.8
Fecal boli incidents, locomotor time 1	1.5	1.6	1.9	-1.4	1.2
Change in fecal boli incidents, locomotor task	4.3	4.0	4.3	1.9	-2.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.5	0.1
Bouts of movement, locomotor time 1	0.5	0.5	0.6	-0.6	0.8
Total resting periods, locomotor time 1	0.6	0.7	0.8	-0.7	0.9
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.2	0.3
Distance moved, locomotor task time 1	0.8	0.9	0.9	1.0	-0.9
Vertical activity count, locomotor time 1	0.6	0.6	0.6	0.8	-0.8
Time >=10cm from walls, locomotor time 2	1.1	1.1	1.4	-1.2	0.9
Bouts of movement, locomotor time 2	0.5	0.5	0.5	0.7	-0.7
Total resting periods, locomotor time 2	0.3	0.4	0.4	0.6	-0.6
Rest time, locomotor task time 2	0.2	0.2	0.4	-0.3	0.6
Distance moved, locomotor task time 2	0.1	0.1	0.1	0.3	-0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.3	0.0
Light reinforcement 1	1.2	2.2	2.9	-1.2	1.7
Light reinforcement 2	1.5	2.0	2.3	-1.3	1.5
Bone: marrow area	0.2	0.4	0.4	-0.7	0.6
Bone: maximum diameter	0.1	0.2	0.2	-0.4	0.5
Bone: maximum force	0.0	0.0	0.0	0.0	-0.1
Bone: maximum moment	0.0	0.0	0.0	-0.1	0.0
Mean time between licks in bursts	2.5	3.5	3.8	1.8	-2.0
Mean num. licks in bursts	1.0	1.3	1.4	-1.2	1.0
Cd content in liver	0.2	0.2	0.2	0.5	-0.4
Co content in liver	5.7	6.7	7.0	-2.6	2.5
Cu content in liver	0.1	0.1	0.1	-0.2	0.3
Fe content in liver	0.0	0.0	0.1	0.0	0.3
K content in liver	1.4	1.4	1.7	1.3	-1.0
Mg content in liver	1.5	1.5	1.7	1.3	-1.1
Mn content in liver	0.0	0.0	0.0	0.1	0.2
Na content in liver	0.8	0.9	1.0	-0.9	1.0
Rb content in liver	0.2	0.3	0.4	0.6	-0.5
Se content in liver	0.8	0.9	1.2	1.1	-0.8
Sr content in liver	0.1	0.1	0.2	0.3	-0.4
Zn content in liver	1.9	2.1	2.1	1.5	-1.5
Bone: minimum diameter	0.3	0.6	0.6	0.8	-0.8
Time in familiar zone, hab. session 1	0.8	0.8	0.8	0.9	-0.9
Time in novel zone, hab. session 1	0.3	0.3	0.3	0.6	-0.5
Total zone transitions, hab. session 1	0.1	0.1	0.1	-0.3	0.3
Total locomotion distance, hab. session 1	0.4	0.6	0.6	-0.8	0.7
Locomotion velocity, hab. session 1	1.2	1.7	1.8	-1.3	1.3
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.2	-0.3
Time in novel zone, hab. session 2	0.2	0.2	0.2	0.4	-0.3
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	-0.2
Total locomotion distance, hab. session 2	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, hab. session 2	0.0	0.0	0.0	-0.1	0.1
Novel to familiar place preference ratio	1.2	1.2	1.4	1.2	-1.0
Novelty place preference	1.8	1.8	2.0	1.4	-1.2
Time in novel zone, NPP test	1.8	1.8	2.1	1.4	-1.2
Total zone transitions, NPP test	0.8	1.1	1.5	-0.9	1.2
Total locomotion distance, NPP test	1.4	1.9	2.2	-1.2	1.5
Locomotion velocity, NPP test	2.1	3.0	3.3	-1.6	1.8
Intraocular pressure	6.2	8.6	8.6	2.9	-2.9
Delta distance traveled before/after self-admin	2.1	2.2	2.4	1.6	-1.4
Delta ambulatory time before/after self-admin	0.5	0.6	0.7	0.8	-0.7
Parametrial fat weight	9.0	17.4	18.2	4.1	-4.3
Pavlov. Cond. lever latency	1.0	1.2	1.3	1.1	-1.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. index score	0.2	0.2	0.3	-0.5	0.5
Pavlov. Cond. latency score	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. lever contacts	0.6	0.7	0.8	-0.9	0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	2.0	2.4	2.5	-1.6	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.0	-1.0	1.0
Pavlov. Cond. response bias	1.2	1.5	1.6	-1.3	1.2
Pavlov. Cond. lever latency	1.3	1.7	1.8	1.3	-1.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	0.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	-0.6	0.6
Pavlov. Cond. index score	0.6	0.8	0.9	-0.9	0.9
Pavlov. Cond. latency score	0.7	0.8	0.8	-0.9	0.9
Pavlov. Cond. lever contacts	0.5	0.6	0.6	-0.8	0.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	0.0
Pavlov. Cond. intertrial magazine entries	3.4	4.4	4.7	2.2	-2.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.4	-0.6	0.6
Pavlov. Cond. response bias	0.8	1.1	1.2	-1.0	1.1
Time in closed arm before self-admin	0.1	0.2	0.3	0.3	-0.5
Time in closed arm after self-admin	0.7	0.7	0.9	0.7	-0.9
Time in open arm before self-admin	0.1	0.1	0.2	0.4	-0.3
Time in open arm after self-admin	0.6	0.7	0.9	-0.7	0.9
Bone: periosteal estimation	0.2	0.4	0.4	-0.7	0.6
Bone: periosteal perimeter	0.0	0.0	0.0	-0.1	0.0
Bone: post-yield work	1.4	1.9	2.2	-1.5	1.3
Progressive ratio test 1 active lever presses	3.7	3.9	4.3	-2.1	1.8
Progressive ratio test 1 breakpoint	3.0	3.2	3.5	-1.9	1.7
Progressive ratio test 1 inactive lever presses	7.2	7.9	8.6	-2.9	2.7
Progressive ratio test 2 active lever presses	1.1	1.2	1.3	-1.1	1.0
Progressive ratio test 2 breakpoint	1.2	1.3	1.4	-1.2	1.1
Progressive ratio test 2 inactive lever presses	3.4	4.0	4.2	-2.1	1.9
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.3	0.4
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.1	0.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.2	0.0
Progressive ratio	0.2	0.2	0.2	-0.5	0.4
Food seeking constrained by brief footshock	10.3	12.6	12.9	-3.6	3.5
Seeking ratio, punishment vs. effort	0.9	1.1	1.1	-1.0	1.1
Retroperitoneal fat weight	28.4	93.3	95.1	9.8	-9.6
Reaction time number correct	0.4	0.5	0.6	-0.8	0.7
Reaction time mean minus median	0.1	0.1	0.2	-0.5	0.1
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.2	-0.2
Reaction time num false alarms	1.1	1.4	2.0	1.4	-0.9
Reaction time num false alarms AUC	1.0	1.4	1.9	1.4	-1.0
Reaction time trials correct on left	0.4	0.5	0.6	-0.8	0.7
Reaction time trials on left	0.4	0.6	0.6	-0.8	0.7
Reaction time mean	0.3	0.4	0.6	0.3	-0.8
Reaction time mean AUC	0.2	0.2	0.4	0.2	-0.7
Median of all reaction times	0.3	0.4	0.7	0.4	-0.8
Reaction time omissions	0.0	0.0	0.0	0.1	-0.0
Reaction time false alarm rate	1.6	2.3	2.9	1.7	-1.3
Reaction time premature initiation rate	0.2	0.3	0.4	0.6	-0.5
Reaction time premature initiations	0.0	0.0	0.0	0.2	-0.1
Std. dev. reaction times	0.1	0.1	0.3	0.0	-0.5
Reaction time trials completed	0.4	0.6	0.6	-0.8	0.7
Reaction time trials AUC	0.5	0.7	0.7	-0.8	0.8
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.4	0.1
Run reversals in cocaine runway, males	0.7	0.7	0.8	-0.9	0.8
Latency to leave start box in cocaine runway	0.7	0.8	0.9	-0.9	0.8
Latency to leave start box in cocaine runway, F	0.3	0.3	0.3	-0.5	0.5
Latency to leave start box in cocaine runway, M	2.1	2.0	2.3	-1.5	1.3
Std. dev. time between licks in bursts	0.8	0.9	1.0	1.0	-0.9
Total sessions with >9 infusions	6.9	7.6	8.0	-2.8	2.7
Short access day 1 total inactive lever presses	4.8	5.4	5.5	-2.3	2.3
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.1	0.5
Short access day 1 total infusions	7.6	8.1	8.7	-2.9	2.7
Short access day 10 total infusions	7.1	7.8	8.3	-2.9	2.7
Short access total infusions	6.2	7.0	7.7	-2.8	2.5
Short access day 1 locomotion	9.3	9.9	10.6	-3.3	3.0
Short access day 10 total locomotion	1.2	1.3	1.4	-1.2	1.1
Short access total locomotion	2.1	2.2	2.5	-1.6	1.4
One hour access (0.3 mA shock)	2.6	3.1	3.1	-1.8	1.7
Compulsive drug intake	2.2	2.2	2.5	1.6	-1.4
One hour access (shock baseline)	5.0	5.8	6.3	-2.5	2.3
Social response proportion	0.0	0.0	0.1	-0.3	0.0
Social responses	0.1	0.1	0.1	0.3	-0.3
Social time	0.0	0.0	0.0	-0.2	-0.1
Soleus weight	3.6	10.5	10.8	-3.3	3.2
Bone: stiffness	0.1	0.2	0.2	0.5	-0.4
Tibialis anterior weight	1.7	5.7	6.9	-2.1	2.6
Time to tail flick, vehicle, before self-admin	1.1	1.2	1.5	0.9	-1.2
Time to tail flick, vehicle, after self-admin	3.8	4.1	4.6	1.9	-2.1
Time to tail flick, test, before self-admin	1.1	1.1	1.4	-1.2	0.9
Time to tail flick, test, after self-admin	0.3	0.3	0.5	-0.7	0.3
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.5	0.7	-0.6
Delta time to tail flick, test, before/after SA	0.9	0.8	1.0	-1.0	0.8
Tibia length	1.7	4.9	5.1	2.3	-2.2
Ambulatory time before self-admin	0.1	0.1	0.1	-0.3	0.4
Ambulatory time after self-admin	0.4	0.5	0.5	0.7	-0.6
Bone: tissue strength	0.6	0.6	0.7	0.7	-0.8
Total heroin consumption	2.2	2.6	2.7	-1.6	1.6
Bone: trabecular number	4.0	6.2	6.9	-2.6	2.3
Bone: trabecular spacing	2.5	3.3	3.8	2.0	-1.6
Bone: trabecular thickness	0.8	0.9	1.1	-1.1	0.8
Bone: trabecular tissue density	0.3	0.4	0.4	-0.7	0.6
Water consumed over 24 hours	0.3	0.3	0.4	-0.6	0.5
Number of responses in last shaping day	2.1	2.1	2.6	-1.6	1.3