Hub : Genes

Gpn1

GPN-loop GTPase 1

chr6:30667337–30685011 (-)

Gpn1 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Gpn1 0.63 0.17 8.2e-07 0.19 0.23 0.19 0.19 1.2e-05 9.7e-07 8.5e-06 1.1e-05
2 IC gene expression Gpn1 0.7 0.14 3.5e-10 0.24 0.27 0.29 0.24 1.9e-10 1.2e-11 1.6e-12 1.8e-10
3 BLA gene expression Gpn1 0.32 0.16 1.1e-14 0.23 0.25 0.25 0.25 1.9e-12 1.7e-13 2.4e-13 1.3e-13
4 Brain gene expression Gpn1 0.33 0.09 0.0e+00 0.35 0.36 0.35 0.35 4.2e-34 2.3e-34 1.0e-33 7.0e-34
5 Brain mRNA stability Gpn1 0.04 0.04 3.9e-04 0.03 0.02 0.02 0.02 1.7e-03 2.7e-03 3.7e-03 4.5e-03
6 NAcc gene expression Gpn1 0.2 0.09 0.0e+00 0.27 0.27 0.28 0.28 1.2e-40 1.6e-41 8.8e-42 5.1e-42
7 pVTA gene expression Gpn1 0.23 0.1 0.0e+00 0.33 0.36 0.36 0.36 2.8e-27 5.9e-30 1.3e-29 3.9e-30
8 OFC gene expression Gpn1 0.36 0.24 4.9e-06 0.18 0.19 0.16 0.18 5.9e-05 2.3e-05 1.4e-04 3.8e-05
9 PL gene expression Gpn1 0.37 0.14 0.0e+00 0.34 0.34 0.34 0.35 1.3e-38 5.2e-39 2.3e-38 9.9e-40
10 Adipose mRNA stability Gpn1 0.02 0.03 7.4e-03 0.01 0.01 0.01 0.01 1.7e-02 3.3e-02 5.4e-02 3.6e-02
11 PL mRNA stability Gpn1 0.08 0.05 2.6e-11 0.1 0.1 0.1 0.1 6.7e-11 3.2e-11 6.7e-11 4.0e-11
12 LHb gene expression Gpn1 0.36 0.22 2.1e-06 0.19 0.22 0.21 0.2 2.6e-05 5.3e-06 1.2e-05 1.9e-05
13 LHb mRNA stability Gpn1 0.13 0.12 8.9e-03 0.08 0.08 0.08 0.08 6.1e-03 6.5e-03 6.2e-03 6.5e-03
14 Liver mRNA stability Gpn1 0.04 0.04 2.0e-04 0.02 0.02 0.01 0.02 3.3e-03 1.5e-03 9.3e-03 5.8e-03
15 IL gene expression Gpn1 0.53 0.21 8.9e-10 0.24 0.22 0.23 0.24 2.0e-06 5.4e-06 2.6e-06 1.9e-06
16 NAcc mRNA stability Gpn1 0.05 0.03 3.2e-09 0.05 0.06 0.05 0.06 8.7e-08 2.5e-09 8.6e-08 7.9e-09
17 Adipose gene expression Gpn1 0.7 0.27 0.0e+00 0.41 0.42 0.42 0.43 3.2e-49 2.9e-51 5.7e-51 5.4e-52
18 Liver gene expression Gpn1 0.46 0.23 0.0e+00 0.34 0.34 0.34 0.34 1.1e-38 7.4e-39 2.9e-38 3.2e-39

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bone: apparent density5.08.611.02.83.33.13.0-3.03.03.03.03.02.8-3.03.0-2.7-3.02.7-2.92.92.8
Area under the delay curve0.20.30.8-0.7-0.00.50.1-0.80.30.20.30.20.4-0.50.6-0.1-0.60.1-0.70.90.9
BMI with tail0.31.01.4-1.1-0.8-1.0-1.00.9-0.9-0.9-1.0-1.0-1.00.9-0.91.20.9-1.20.9-0.9-0.8
BMI without tail0.72.12.5-1.3-1.6-1.5-1.41.5-1.4-1.3-1.4-1.3-1.41.4-1.41.61.4-1.61.4-1.5-1.4
Body weight2.29.811.7-3.4-3.4-3.3-3.33.1-3.2-3.0-3.1-3.0-3.13.1-3.03.33.0-3.33.0-3.0-2.8
Weight adjusted by age0.10.10.70.90.00.30.4-0.10.20.20.20.10.5-0.10.1-0.5-0.10.5-0.10.10.1
Bone surface2.95.26.82.52.62.42.4-2.22.42.42.32.42.2-2.32.3-2.0-2.22.0-2.22.12.2
Bone volume2.95.27.42.42.72.42.4-2.22.42.42.32.42.1-2.32.3-2.0-2.32.0-2.22.12.1
Breakpoint value in progressive ratio session0.81.01.80.60.30.90.8-1.00.90.90.90.91.2-1.01.0-1.3-1.01.3-1.11.11.0
Number of licking bursts0.10.10.4-0.20.40.30.2-0.60.30.30.20.20.1-0.30.30.2-0.4-0.2-0.40.30.4
Context. condit. distance diff. score0.00.00.00.0-0.0-0.10.00.2-0.00.10.00.00.0-0.00.0-0.0-0.00.0-0.00.00.0
Locomotion velocity, session 10.00.00.10.30.3-0.00.00.20.00.1-0.00.1-0.30.1-0.10.40.2-0.40.2-0.3-0.3
Locomotion distance, session 11.92.44.41.52.11.61.6-1.51.71.71.61.71.3-1.61.6-1.2-1.61.2-1.61.51.4
Locomotion velocity, session 20.30.30.6-0.7-0.4-0.5-0.50.6-0.5-0.5-0.5-0.5-0.60.5-0.50.80.5-0.80.5-0.5-0.5
Locomotion distance, session 20.00.00.20.30.40.10.10.00.10.10.10.1-0.0-0.10.00.1-0.0-0.10.0-0.1-0.1
Locomotion velocity, session 30.70.81.11.00.90.80.9-0.60.80.90.90.81.0-0.80.8-1.1-0.81.1-0.80.80.7
Locomotion distance, session 30.80.91.61.01.31.01.0-0.91.01.01.01.00.9-1.00.9-0.8-0.90.8-0.90.90.8
Stereotopy head waving bouts, day 31.92.33.21.61.21.51.5-1.31.51.51.51.51.5-1.51.5-1.8-1.41.8-1.41.41.5
Stereotopy head waving duration, day 30.10.20.50.50.10.30.4-0.10.30.30.40.40.4-0.30.3-0.7-0.30.7-0.30.30.4
Locomotion velocity, session 71.31.42.51.61.31.31.3-1.11.21.21.21.21.2-1.11.1-1.1-1.11.1-1.01.01.0
Locomotion distance, session 70.10.10.60.80.40.30.40.10.30.40.30.40.4-0.20.2-0.3-0.20.3-0.10.10.1
Stereotopy head waving bouts, day 70.00.00.1-0.00.10.20.1-0.20.10.10.10.1-0.1-0.10.10.0-0.1-0.0-0.10.10.1
Stereotopy head waving duration, day 70.30.30.50.40.40.60.5-0.70.50.50.50.50.5-0.60.6-0.6-0.60.6-0.60.60.6
Locomotion velocity, session 80.20.31.31.10.40.50.6-0.20.50.50.50.50.7-0.40.3-0.5-0.30.5-0.30.30.3
Locomotion distance, session 80.30.50.80.80.90.70.7-0.40.70.80.70.80.6-0.70.7-0.6-0.70.6-0.60.60.6
Degree of sensitization distance0.80.81.1-0.6-0.9-0.9-0.81.1-0.9-0.9-0.9-0.8-0.80.9-0.90.90.9-0.90.9-0.9-0.9
Degree of sensitization stereotypy0.20.30.7-0.8-0.4-0.4-0.60.2-0.5-0.5-0.5-0.5-0.70.4-0.40.70.4-0.70.4-0.5-0.4
Conditioned locomotion3.03.53.81.71.91.91.8-1.71.81.91.91.81.9-1.91.9-1.9-1.91.9-1.91.91.9
Cocaine response after cond. corrected0.70.91.20.40.90.90.9-1.00.90.80.90.90.9-1.01.1-0.9-1.10.9-1.11.11.1
Cocaine response after cond. not corrected1.72.02.50.81.51.51.3-1.51.41.31.41.41.2-1.51.5-1.2-1.61.2-1.61.51.6
Cocaine response before conditioning1.41.62.31.51.51.51.4-1.51.41.41.31.31.1-1.31.2-0.8-1.20.8-1.11.11.1
Saline control response0.60.81.41.21.00.91.0-0.70.91.00.90.90.9-0.90.8-1.0-0.81.0-0.80.80.8
Bone: connectivity density4.87.48.72.62.92.82.8-2.82.82.82.72.72.5-2.82.7-2.6-2.82.6-2.72.72.7
Bone: cortical apparent density0.50.71.10.51.00.90.8-1.10.80.80.80.80.7-0.90.9-0.7-0.90.7-0.90.90.9
Bone: cortical area0.71.11.91.01.41.01.1-1.11.11.21.11.10.9-1.11.1-0.7-1.10.7-1.01.01.1
Bone: cortical porosity1.11.21.41.21.21.11.1-1.21.11.11.11.11.0-1.11.0-1.1-1.01.1-1.01.01.0
Bone: cortical porosity1.31.41.61.31.21.21.2-1.31.21.21.21.21.1-1.21.1-1.2-1.11.2-1.11.11.1
Bone: cortical thickness0.00.00.4-0.00.60.10.1-0.10.10.20.10.2-0.2-0.10.10.3-0.1-0.3-0.10.00.0
Bone: cortical thickness1.61.92.31.31.51.31.3-1.41.41.41.41.41.4-1.41.4-1.3-1.41.3-1.31.41.3
Bone: cortical tissue density0.40.50.80.40.80.80.6-0.90.70.70.70.70.6-0.70.7-0.6-0.80.6-0.80.80.7
Condit. Reinf. active minus inactive responses0.60.71.1-1.0-0.8-0.8-0.90.7-0.8-0.8-0.8-0.9-0.80.8-0.80.90.7-0.90.7-0.7-0.8
Condit. Reinf. active-inactive response ratio0.70.81.4-1.2-0.9-0.9-0.90.7-0.9-0.9-0.9-1.0-0.80.9-0.80.90.8-0.90.8-0.7-0.8
Condit. Reinf. active responses0.20.20.40.00.60.50.4-0.60.50.40.40.40.2-0.50.5-0.2-0.50.2-0.50.50.5
Condit. Reinf. inactive responses1.62.02.61.21.61.51.4-1.61.51.51.51.51.1-1.51.5-1.1-1.51.1-1.51.31.4
Incentive salience index mean0.00.00.1-0.10.30.20.1-0.30.20.10.10.10.1-0.20.2-0.1-0.20.1-0.20.20.1
Condit. Reinf. lever presses0.71.01.50.71.21.11.0-1.21.01.01.00.90.9-1.11.1-0.9-1.10.9-1.11.11.0
Condit. Reinf. active minus inactive responses3.34.34.61.82.12.02.1-2.12.12.12.12.12.1-2.12.1-1.9-2.11.9-2.12.22.1
Condit. Reinf. active-inactive response ratio0.80.91.20.71.10.91.0-1.01.01.01.01.00.8-1.01.0-0.8-1.00.8-1.01.01.0
Condit. Reinf. active responses2.94.14.51.81.92.02.0-2.12.02.02.02.02.1-2.02.0-2.0-2.12.0-2.12.12.1
Condit. Reinf. inactive responses1.62.12.51.31.21.51.4-1.51.41.41.41.31.6-1.41.4-1.5-1.41.5-1.51.51.5
Condit. Reinf. lever presses1.92.63.11.41.61.61.6-1.71.61.61.61.61.8-1.71.7-1.4-1.71.4-1.71.81.7
Condit. Reinf. lever reinforcers received2.63.64.01.81.82.01.9-2.01.91.91.91.92.0-1.91.9-1.8-1.91.8-1.92.01.9
Conditioned reinforcement - actives1.01.74.62.20.61.01.3-1.11.11.31.21.41.8-1.00.9-1.9-0.91.9-0.91.11.1
Conditioned reinforcement - inactives3.04.46.22.52.12.42.3-2.52.22.02.12.02.0-2.02.0-2.0-1.92.0-1.91.81.9
Conditioned locomotion0.30.42.71.7-0.50.00.30.50.10.20.20.40.90.1-0.2-1.00.31.00.3-0.0-0.1
Patch foraging indifference point 0 sec0.30.60.9-0.8-0.5-0.8-0.80.5-0.8-0.8-0.9-0.9-0.90.8-0.80.60.8-0.60.8-0.9-0.9
Patch foraging indifference point AUC1.52.13.81.82.01.41.5-1.31.61.71.51.71.2-1.51.4-1.1-1.31.1-1.21.11.1
Delay disc. indifference point, 0s delay2.93.15.8-2.4-2.0-1.6-1.91.3-1.8-1.9-1.8-1.9-1.81.7-1.62.01.6-2.01.5-1.3-1.3
Delay disc. indifference point, 16s delay0.20.20.6-0.80.10.40.1-0.70.20.20.30.20.1-0.40.5-0.1-0.60.1-0.70.60.7
Delay disc. indifference point, 2s delay0.10.20.4-0.5-0.5-0.3-0.40.2-0.4-0.4-0.4-0.4-0.30.4-0.30.60.3-0.60.3-0.2-0.2
Delay disc. indifference point, 24s delay1.31.43.1-0.70.61.10.7-1.80.90.91.00.91.0-1.31.4-0.7-1.60.7-1.71.71.6
Delay disc. indifference point, 4s delay0.00.00.10.10.00.30.1-0.10.10.10.10.10.2-0.10.10.1-0.1-0.1-0.10.20.3
Delay disc. indifference point, 8s delay0.20.20.6-0.8-0.20.3-0.0-0.80.10.00.20.10.4-0.30.4-0.1-0.50.1-0.60.80.7
Indifference point function ln k0.00.00.10.3-0.20.00.1-0.0-0.0-0.10.0-0.10.20.0-0.0-0.30.00.3-0.00.10.1
Indifference point function log k0.00.00.10.3-0.20.00.1-0.0-0.0-0.10.0-0.10.20.0-0.0-0.30.00.3-0.00.10.1
Patch foraging total patch changes 0 sec0.30.60.8-0.8-0.5-0.7-0.80.4-0.8-0.8-0.8-0.9-0.80.8-0.80.70.8-0.70.8-0.8-0.9
Patch foraging total patch changes 12 sec1.01.31.6-1.0-0.8-1.1-1.11.0-1.1-1.1-1.1-1.1-1.31.1-1.11.21.1-1.21.2-1.2-1.3
Patch foraging total patch changes 18 sec0.00.10.20.10.1-0.3-0.20.2-0.2-0.1-0.2-0.1-0.30.3-0.30.20.4-0.20.4-0.4-0.5
Patch foraging total patch changes 24 sec0.81.32.0-0.6-0.8-1.2-1.01.3-1.1-1.0-1.1-1.0-1.11.2-1.21.21.3-1.21.3-1.3-1.4
Patch foraging total patch changes 6 sec0.10.20.4-0.3-0.1-0.3-0.40.2-0.3-0.3-0.4-0.4-0.60.4-0.40.50.4-0.50.4-0.5-0.6
Patch foraging time to switch 0 sec0.00.10.5-0.7-0.6-0.2-0.30.2-0.2-0.4-0.2-0.3-0.20.1-0.00.2-0.0-0.2-0.10.10.2
Patch foraging water rate 0 sec0.00.00.40.60.20.10.1-0.20.10.20.10.20.2-0.0-0.0-0.20.10.20.1-0.1-0.2
Patch foraging water rate 12 sec1.02.22.7-1.3-1.6-1.5-1.51.4-1.5-1.5-1.5-1.5-1.41.5-1.51.31.5-1.31.5-1.6-1.7
Patch foraging water rate 18 sec0.61.01.5-0.9-1.2-0.9-1.01.0-1.0-1.0-1.0-1.0-1.01.0-1.00.91.0-0.91.0-1.0-0.9
Patch foraging water rate 24 sec2.33.35.0-2.0-2.2-2.0-2.01.9-2.0-1.8-1.8-1.8-1.51.8-1.81.51.7-1.51.7-1.6-1.7
Patch foraging water rate 6 sec1.31.82.1-1.2-1.4-1.3-1.41.3-1.4-1.3-1.3-1.3-1.41.4-1.41.41.4-1.41.4-1.5-1.3
Seeking ratio, delayed vs. immediate footshock0.10.10.40.6-0.1-0.1-0.00.6-0.2-0.2-0.2-0.1-0.20.3-0.40.20.4-0.20.5-0.4-0.4
Distance traveled before self-admin0.00.00.2-0.30.0-0.1-0.10.3-0.00.1-0.00.0-0.10.00.00.4-0.0-0.4-0.00.00.1
Distance traveled after self-admin1.92.43.2-1.6-1.1-1.7-1.51.8-1.5-1.3-1.5-1.3-1.71.5-1.41.71.4-1.71.5-1.6-1.6
Extensor digitorum longus weight4.517.718.53.84.14.34.2-4.34.24.24.24.24.2-4.34.3-4.1-4.34.1-4.34.34.3
Bone: elastic displacement0.70.81.70.50.70.80.7-0.80.70.70.80.71.0-0.80.8-1.3-0.91.3-0.91.00.9
Bone: elastic work1.01.31.80.81.11.11.1-1.21.11.11.11.01.2-1.11.1-1.4-1.21.4-1.21.21.2
Bone: endosteal estimation0.81.62.11.41.11.21.3-1.31.31.31.31.31.4-1.31.3-1.2-1.21.2-1.21.31.3
Bone: endosteal perimeter0.30.70.90.80.60.80.8-0.80.80.80.80.80.9-0.80.8-0.7-0.80.7-0.80.90.9
Epididymis fat weight16.958.070.7-7.5-8.4-8.0-7.87.7-7.8-7.8-7.7-7.7-7.27.7-7.67.27.6-7.27.5-7.4-7.4
Delta time in closed arm before/after self-admin0.00.00.10.1-0.2-0.00.10.00.10.20.10.20.2-0.10.1-0.3-0.10.3-0.10.10.2
Delta time in open arm before/after self-admin0.10.10.30.20.30.30.3-0.30.30.20.30.20.3-0.30.4-0.4-0.40.4-0.40.50.5
Diff in mean of infusions in LGA sessions0.00.00.30.3-0.10.20.1-0.20.20.20.10.10.2-0.10.1-0.5-0.10.5-0.10.1-0.0
Delay discount exponential model param0.50.61.40.4-0.3-0.8-0.41.0-0.6-0.5-0.6-0.5-0.70.8-0.90.41.0-0.41.0-1.2-1.2
Extinction: sum of active levers before priming0.30.40.60.10.30.50.5-0.80.60.60.60.50.6-0.70.7-0.5-0.80.5-0.80.70.7
Active lever presses in extinction session 60.50.51.31.10.20.50.7-0.40.60.70.60.71.0-0.50.5-1.0-0.51.0-0.50.60.5
Bone: final force0.10.20.30.50.50.30.5-0.30.40.50.50.50.5-0.40.4-0.3-0.40.3-0.40.50.5
Bone: final moment0.20.30.40.60.70.40.6-0.40.50.60.50.60.6-0.50.5-0.4-0.50.4-0.50.50.5
Food consumed during 24 hour testing period0.20.20.50.60.70.50.6-0.50.60.60.50.50.3-0.50.5-0.3-0.50.3-0.40.40.4
Glucose0.20.30.5-0.2-0.6-0.6-0.50.7-0.5-0.6-0.6-0.6-0.50.6-0.60.50.7-0.50.7-0.7-0.7
Heart weight2.94.56.0-1.7-1.7-2.0-2.02.1-2.0-1.9-2.1-2.0-2.42.1-2.22.52.2-2.52.3-2.4-2.2
Delay discount hyperbolic model param0.30.30.90.4-0.1-0.6-0.30.8-0.4-0.4-0.5-0.4-0.50.6-0.70.30.7-0.30.8-1.0-1.0
Intermittent access intake day 1-15 change0.10.10.90.90.1-0.10.10.10.20.50.20.50.4-0.0-0.0-0.40.10.40.2-0.1-0.0
Intermittent access intake escalation0.00.10.30.6-0.2-0.4-0.20.2-0.00.2-0.10.20.00.2-0.3-0.10.30.10.4-0.3-0.3
Intermittent access intake escalation 20.10.10.80.90.2-0.00.10.20.20.20.00.3-0.20.1-0.20.00.3-0.00.4-0.5-0.3
Intermitt. access day 1 inactive lever presses0.41.53.31.81.41.41.5-0.91.31.21.21.21.3-1.11.1-1.2-1.01.2-1.01.01.0
Intermitt. access day 15 inactive lever presses3.97.916.34.03.73.03.3-2.23.03.12.93.02.5-2.72.6-2.5-2.52.5-2.32.12.2
Intermitt. access escalation Index0.30.40.9-0.20.3-0.7-0.50.9-0.4-0.2-0.5-0.3-0.80.5-0.60.80.6-0.80.7-0.8-0.9
Intermittent access day 1 total infusions3.15.06.52.52.12.32.4-2.62.22.12.22.22.3-2.22.1-2.3-2.12.3-2.12.12.0
Intermittent access day 15 total infusions1.42.04.02.01.31.31.5-1.51.51.61.41.61.5-1.31.3-1.5-1.21.5-1.21.11.1
Intermittent access terminal intake (last 3 days)2.12.85.22.31.61.51.8-1.71.81.81.71.91.7-1.61.5-1.8-1.41.8-1.41.41.3
Intermittent access total infusions2.02.33.41.81.01.41.5-1.81.41.41.51.51.8-1.41.4-1.8-1.41.8-1.41.51.4
Intermittent access day 1 locomotion1.72.12.51.31.21.41.5-1.61.51.41.41.41.6-1.51.5-1.5-1.51.5-1.51.51.4
Intermittent access day 15 total locomotion0.20.31.11.00.20.60.6-0.70.50.50.50.40.8-0.40.4-0.7-0.30.7-0.30.40.4
Intermittent access total locomotion0.30.30.90.8-0.30.50.5-0.70.40.30.40.40.9-0.40.4-0.9-0.30.9-0.40.60.5
Intermittent access standard deviation0.71.52.91.71.11.31.3-1.21.21.11.21.21.3-1.21.1-1.4-1.11.4-1.11.11.0
Left kidney weight0.00.10.4-0.4-0.6-0.3-0.30.2-0.2-0.2-0.2-0.2-0.10.2-0.20.20.1-0.20.1-0.1-0.1
Right kidney weight0.52.15.2-2.3-1.7-1.4-1.60.9-1.4-1.4-1.4-1.5-1.61.3-1.21.61.1-1.61.1-1.1-1.0
Cocaine induced anxiety0.20.30.91.00.60.60.6-0.60.70.60.60.60.5-0.50.5-0.5-0.50.5-0.40.40.4
Post-drug Anxiety1.21.21.6-1.0-1.1-1.1-1.10.8-1.0-1.1-1.1-1.1-1.21.1-1.11.31.1-1.31.1-1.2-1.2
Baseline Anxiety3.33.85.2-2.3-2.0-1.9-2.01.6-2.0-2.1-2.0-2.0-1.91.9-1.91.91.9-1.91.8-1.8-1.9
Tail length0.51.93.5-1.1-1.9-1.4-1.41.5-1.4-1.2-1.3-1.2-1.21.4-1.41.31.4-1.31.4-1.5-1.3
Length with tail2.08.613.3-2.8-3.6-3.1-3.13.0-3.0-2.9-2.9-2.8-2.73.0-2.92.72.9-2.72.9-2.8-2.7
Length without tail0.62.03.1-1.4-1.8-1.6-1.41.4-1.5-1.4-1.5-1.4-1.31.5-1.51.21.4-1.21.4-1.3-1.3
LgA early post infusion interval1.21.62.5-1.6-1.3-1.4-1.31.3-1.3-1.4-1.2-1.3-1.01.2-1.21.21.1-1.21.1-1.0-1.1
LgA late post infusion interval0.60.82.11.40.30.60.9-0.30.60.80.70.71.4-0.60.6-1.4-0.51.4-0.60.70.6
LgA early loading2.75.16.72.62.32.22.3-2.02.32.32.32.32.3-2.22.2-2.4-2.12.4-2.12.12.2
LgA late loading0.51.21.60.70.71.21.0-1.21.11.11.11.11.1-1.21.2-1.0-1.21.0-1.21.21.3
LgA early average infusions2.53.24.42.11.71.81.8-1.71.81.81.81.81.8-1.71.7-1.8-1.71.8-1.71.71.7
LgA late average infusions1.31.83.2-1.8-1.5-1.1-1.50.9-1.3-1.4-1.3-1.4-1.51.2-1.21.71.2-1.71.2-1.1-1.1
LgA early timeout3.63.85.22.31.82.02.0-1.82.02.02.02.02.0-1.91.9-2.0-1.82.0-1.81.81.9
LgA late timeout0.30.41.1-1.1-0.6-0.6-0.70.2-0.5-0.6-0.6-0.6-0.70.5-0.50.80.4-0.80.4-0.4-0.4
LgA early titration1.31.92.81.71.41.51.5-1.11.41.41.41.41.2-1.31.3-1.5-1.31.5-1.31.21.3
LgA late titration1.32.03.3-1.6-1.5-1.2-1.41.2-1.3-1.4-1.3-1.4-1.61.3-1.31.81.2-1.81.3-1.2-1.1
LgA total infusion0.30.41.1-0.6-1.0-0.5-0.70.3-0.6-0.7-0.6-0.6-0.60.6-0.60.70.6-0.70.6-0.5-0.5
Times rat made contact with spout2.12.42.81.11.51.51.5-1.51.51.51.51.51.5-1.61.6-1.5-1.61.5-1.71.71.7
Lifetime Intake2.22.74.22.11.11.51.7-1.91.51.51.61.62.0-1.41.4-2.0-1.42.0-1.41.51.4
Liver weight, left3.86.36.7-2.4-2.5-2.5-2.52.2-2.5-2.6-2.5-2.5-2.62.5-2.52.62.5-2.62.5-2.6-2.5
Liver weight, right10.217.918.7-3.9-4.1-4.3-4.24.3-4.2-4.1-4.2-4.2-4.34.2-4.34.34.3-4.34.3-4.3-4.2
Locomotor activity0.20.41.5-1.2-0.8-0.5-0.70.3-0.6-0.7-0.6-0.7-0.60.5-0.50.70.4-0.70.4-0.2-0.3
Locomotor testing distance0.10.30.5-0.10.40.40.3-0.50.40.40.40.40.4-0.50.6-0.6-0.60.6-0.60.70.7
Locomotor testing rearing0.51.02.40.80.40.70.8-0.70.80.80.90.81.4-0.80.9-1.5-0.91.5-1.01.11.0
Locomotion in novel chamber0.30.41.3-0.3-0.9-1.0-0.61.1-0.7-0.6-0.5-0.4-0.20.7-0.60.20.7-0.20.7-0.5-0.6
Locomotion in novel chamber post-restriction3.15.07.3-2.7-2.5-2.3-2.42.3-2.4-2.4-2.3-2.3-2.22.2-2.11.92.1-1.92.0-2.1-2.1
Fecal boli incidents, locomotor time 10.20.30.50.30.70.40.5-0.20.50.60.50.60.3-0.60.6-0.5-0.60.5-0.60.60.7
Change in fecal boli incidents, locomotor task4.34.24.6-2.0-2.1-2.1-2.11.9-2.1-2.1-2.1-2.1-1.92.1-2.11.92.1-1.92.0-2.0-2.1
Time >=10cm from walls, locomotor time 10.10.10.9-0.9-0.3-0.3-0.40.2-0.3-0.2-0.3-0.3-0.00.2-0.10.40.1-0.40.00.2-0.0
Bouts of movement, locomotor time 11.92.13.51.11.31.31.4-1.31.51.51.51.51.5-1.51.6-1.1-1.61.1-1.61.71.9
Total resting periods, locomotor time 12.22.53.71.41.51.41.6-1.41.61.61.61.61.5-1.61.6-1.3-1.71.3-1.61.81.9
Rest time, locomotor task time 10.00.10.2-0.1-0.3-0.3-0.20.5-0.2-0.3-0.2-0.2-0.10.3-0.30.10.3-0.10.3-0.2-0.2
Distance moved, locomotor task time 10.81.21.9-1.4-1.0-1.2-1.21.0-1.1-1.0-1.1-1.1-1.21.1-1.01.11.0-1.11.0-1.1-1.1
Vertical activity count, locomotor time 10.20.51.0-1.0-0.5-0.8-0.80.5-0.6-0.7-0.7-0.7-0.80.7-0.60.80.6-0.80.6-0.7-0.7
Time >=10cm from walls, locomotor time 20.20.20.90.90.10.50.5-0.10.40.50.50.50.9-0.40.4-0.4-0.40.4-0.40.60.5
Bouts of movement, locomotor time 20.00.10.2-0.3-0.3-0.4-0.20.2-0.2-0.2-0.2-0.20.10.1-0.10.50.1-0.50.1-0.0-0.1
Total resting periods, locomotor time 20.00.00.20.30.1-0.00.2-0.20.20.10.20.20.4-0.20.20.1-0.1-0.1-0.10.30.2
Rest time, locomotor task time 21.41.72.21.21.41.51.3-1.51.31.21.31.31.3-1.31.3-1.2-1.31.2-1.31.41.3
Distance moved, locomotor task time 21.11.31.7-0.9-1.3-1.2-1.11.3-1.2-1.0-1.2-1.1-1.11.2-1.21.11.2-1.11.2-1.2-1.2
Vertical activity count, locomotor time 20.50.71.1-0.4-1.0-1.0-0.81.1-0.8-0.8-0.8-0.8-0.50.9-0.90.80.9-0.80.9-0.9-0.9
Light reinforcement 13.17.79.62.73.12.92.8-3.12.92.92.82.92.5-2.82.8-2.4-2.82.4-2.72.72.7
Light reinforcement 23.35.16.82.42.62.42.4-2.52.42.42.32.42.0-2.32.2-1.8-2.21.8-2.22.12.2
Bone: marrow area0.71.62.01.41.11.21.3-1.31.31.31.31.31.4-1.31.2-1.2-1.21.2-1.21.31.3
Bone: maximum diameter1.32.52.71.51.71.51.6-1.61.61.61.61.61.5-1.61.6-1.3-1.61.3-1.61.61.6
Bone: maximum force0.20.30.40.70.60.40.6-0.40.50.60.60.60.6-0.50.5-0.4-0.50.4-0.50.60.5
Bone: maximum moment0.30.40.70.70.80.60.7-0.50.70.80.70.70.7-0.70.7-0.6-0.60.6-0.60.70.7
Mean time between licks in bursts1.53.84.5-2.0-1.7-1.9-2.01.9-1.9-1.9-2.0-1.9-2.11.9-1.92.01.9-2.01.9-2.0-2.0
Mean num. licks in bursts0.10.20.50.50.30.40.4-0.10.40.40.40.40.5-0.40.4-0.7-0.40.7-0.40.40.3
Cd content in liver0.00.00.0-0.00.10.00.1-0.00.10.10.10.10.1-0.10.1-0.2-0.10.2-0.10.20.1
Co content in liver6.37.37.82.42.82.72.7-2.82.72.82.72.82.7-2.82.8-2.5-2.82.5-2.82.82.8
Cu content in liver0.10.10.10.20.30.30.3-0.30.30.30.30.30.2-0.30.3-0.2-0.30.2-0.30.30.3
Fe content in liver0.70.91.51.20.90.91.0-0.71.01.00.90.91.0-0.90.9-1.2-0.81.2-0.80.80.8
K content in liver0.50.51.00.91.00.70.8-0.50.80.90.80.80.6-0.80.7-0.3-0.70.3-0.70.60.6
Mg content in liver0.60.61.10.81.00.80.8-0.60.80.90.80.80.6-0.80.8-0.4-0.80.4-0.70.60.7
Mn content in liver0.10.10.20.50.20.20.30.00.30.30.30.30.4-0.30.3-0.5-0.20.5-0.20.30.2
Na content in liver0.50.50.90.90.80.70.8-0.60.80.80.70.80.7-0.70.7-0.6-0.70.6-0.60.60.6
Rb content in liver0.00.00.0-0.10.20.10.1-0.00.10.10.10.10.0-0.10.1-0.0-0.10.0-0.10.10.1
Se content in liver0.10.20.40.1-0.5-0.4-0.30.7-0.4-0.3-0.3-0.3-0.20.4-0.50.20.5-0.20.5-0.4-0.4
Sr content in liver0.20.10.3-0.6-0.4-0.4-0.40.3-0.4-0.4-0.4-0.4-0.40.3-0.30.40.3-0.40.3-0.3-0.3
Zn content in liver0.80.81.1-0.7-0.8-0.9-0.91.0-0.9-0.8-0.9-0.8-0.90.9-0.91.00.9-1.01.0-1.0-1.0
Bone: minimum diameter0.00.00.10.1-0.0-0.1-0.10.0-0.1-0.1-0.1-0.1-0.10.1-0.20.20.2-0.20.2-0.2-0.2
Time in familiar zone, hab. session 10.60.61.0-0.5-0.8-0.8-0.71.0-0.8-0.8-0.7-0.7-0.80.8-0.80.80.8-0.80.9-0.8-0.8
Time in novel zone, hab. session 10.70.71.3-0.8-1.1-0.9-0.90.9-0.9-0.9-0.9-0.9-0.60.9-0.80.40.8-0.40.8-0.7-0.8
Total zone transitions, hab. session 10.10.20.20.40.50.40.4-0.30.40.40.40.40.3-0.40.4-0.4-0.40.4-0.40.40.4
Total locomotion distance, hab. session 10.20.30.50.70.50.60.6-0.40.60.50.50.60.4-0.50.5-0.5-0.40.5-0.40.40.4
Locomotion velocity, hab. session 11.11.52.01.21.41.41.3-1.31.31.31.31.31.0-1.31.3-1.1-1.31.1-1.21.11.2
Time in familiar zone, hab. session 20.00.00.10.30.1-0.00.20.10.10.10.10.20.2-0.10.1-0.1-0.00.1-0.00.00.0
Time in novel zone, hab. session 20.60.61.1-1.0-0.8-0.7-0.80.5-0.8-0.8-0.8-0.9-0.80.7-0.70.70.7-0.70.7-0.6-0.6
Total zone transitions, hab. session 20.10.10.20.10.40.40.3-0.50.40.40.40.40.2-0.40.4-0.2-0.40.2-0.40.40.4
Total locomotion distance, hab. session 20.20.30.60.40.70.60.5-0.60.60.50.50.60.3-0.60.6-0.3-0.60.3-0.50.40.5
Locomotion velocity, hab. session 20.40.50.90.61.00.80.7-0.90.80.70.80.80.5-0.80.8-0.5-0.80.5-0.80.70.7
Novel to familiar place preference ratio1.01.11.7-1.3-1.0-1.0-1.10.7-1.0-1.1-1.0-1.1-1.01.0-1.01.10.9-1.10.9-0.9-1.0
Novelty place preference1.61.72.5-1.6-1.3-1.3-1.41.0-1.3-1.4-1.3-1.4-1.31.3-1.31.31.2-1.31.2-1.2-1.2
Time in novel zone, NPP test1.92.02.7-1.6-1.5-1.4-1.51.1-1.4-1.5-1.4-1.5-1.41.4-1.41.41.4-1.41.3-1.3-1.4
Total zone transitions, NPP test1.52.23.31.31.81.51.5-1.51.51.51.51.61.2-1.51.5-1.3-1.51.3-1.51.41.4
Total locomotion distance, NPP test2.02.73.51.61.91.71.7-1.71.71.71.71.71.5-1.71.7-1.5-1.71.5-1.61.51.6
Locomotion velocity, NPP test3.44.75.62.02.42.32.2-2.32.22.22.22.22.0-2.22.2-2.0-2.22.0-2.22.12.1
Intraocular pressure5.68.112.7-3.6-2.8-2.9-3.02.5-3.0-3.0-2.9-3.0-2.92.8-2.72.82.6-2.82.6-2.6-2.7
Delta distance traveled before/after self-admin1.71.82.6-0.9-0.9-1.4-1.21.5-1.3-1.2-1.3-1.2-1.51.4-1.41.31.4-1.31.5-1.6-1.6
Delta ambulatory time before/after self-admin0.20.20.4-0.20.1-0.5-0.40.5-0.4-0.3-0.4-0.3-0.60.4-0.50.50.5-0.50.5-0.6-0.6
Parametrial fat weight11.126.131.8-4.8-4.4-5.1-5.15.3-5.0-4.9-5.1-4.9-5.55.0-5.15.65.1-5.65.2-5.2-5.1
Pavlov. Cond. lever latency1.92.43.2-1.5-1.8-1.7-1.61.7-1.7-1.6-1.6-1.6-1.41.6-1.51.31.5-1.31.5-1.5-1.5
Pavlov. Cond. magazine entry latency0.10.10.40.40.60.40.4-0.30.40.40.30.40.2-0.30.3-0.2-0.30.2-0.30.20.2
Pavlov. Cond. change in total contacts0.00.10.10.20.30.30.2-0.30.30.20.20.20.1-0.20.2-0.1-0.20.1-0.20.20.2
Pavlov. Cond. index score0.81.12.01.01.41.21.1-1.11.11.11.01.00.8-1.11.0-0.7-1.00.7-1.00.90.9
Pavlov. Cond. latency score0.81.11.91.11.41.21.1-1.11.11.11.01.10.9-1.01.0-0.8-1.00.8-1.00.90.9
Pavlov. Cond. lever contacts1.31.52.21.21.51.41.3-1.41.31.31.21.21.1-1.31.2-1.0-1.21.0-1.21.21.2
Pavlov. Cond. magazine entry number0.50.71.4-0.9-1.2-0.9-0.90.8-0.9-0.9-0.8-0.9-0.60.8-0.80.60.8-0.60.7-0.7-0.7
Pavlov. Cond. intertrial magazine entries1.21.42.00.81.21.21.1-1.41.21.11.21.11.0-1.21.2-1.2-1.31.2-1.31.21.3
Pavlov. Cond. lever-magazine prob. diff.1.51.92.91.21.71.51.4-1.51.51.41.41.41.2-1.41.4-1.1-1.41.1-1.41.31.3
Pavlov. Cond. response bias1.41.82.81.31.71.51.4-1.41.41.41.31.41.1-1.41.3-1.1-1.31.1-1.31.21.2
Pavlov. Cond. lever latency1.41.92.6-1.3-1.1-1.4-1.41.5-1.4-1.4-1.4-1.4-1.61.4-1.41.11.4-1.11.4-1.5-1.5
Pavlov. Cond. magazine entry latency0.30.41.21.10.60.60.7-0.60.60.60.60.60.8-0.50.5-0.4-0.40.4-0.40.50.4
Pavlov. Cond. change in total contacts0.61.01.70.90.81.00.9-1.11.00.91.00.91.3-1.01.0-0.9-1.00.9-1.11.21.1
Pavlov. Cond. index score1.11.52.31.41.11.21.3-1.31.21.21.31.21.5-1.21.2-1.0-1.21.0-1.21.31.2
Pavlov. Cond. latency score1.21.62.51.51.11.21.3-1.31.31.31.31.31.6-1.21.2-1.1-1.21.1-1.21.31.2
Pavlov. Cond. lever contacts1.01.31.81.00.91.11.1-1.31.11.11.21.11.4-1.21.2-0.9-1.20.9-1.21.31.3
Pavlov. Cond. magazine entry number0.20.20.6-0.8-0.5-0.4-0.50.5-0.5-0.5-0.5-0.5-0.70.4-0.40.30.4-0.30.4-0.5-0.4
Pavlov. Cond. intertrial magazine entries3.65.47.2-2.7-2.6-2.4-2.52.1-2.4-2.4-2.4-2.4-2.42.3-2.32.22.2-2.22.2-2.2-2.2
Pavlov. Cond. lever-magazine prob. diff.0.81.11.71.20.91.01.1-1.11.01.01.01.01.3-1.01.0-0.8-1.00.8-1.01.11.0
Pavlov. Cond. response bias1.62.22.71.41.31.51.5-1.61.51.51.51.51.6-1.51.5-1.1-1.51.1-1.51.61.6
LgA PC1 addiction-like behavior0.10.10.20.10.40.40.3-0.50.40.30.30.30.1-0.40.4-0.1-0.40.1-0.40.40.4
Time in closed arm before self-admin0.81.01.7-0.6-1.3-1.0-0.91.1-1.1-1.2-1.0-1.1-0.81.1-1.10.61.1-0.61.1-1.0-1.0
Time in closed arm after self-admin1.41.52.9-1.0-1.7-1.3-1.21.4-1.3-1.4-1.3-1.3-0.91.3-1.30.61.3-0.61.2-1.2-1.2
Time in open arm before self-admin0.10.10.5-0.20.30.40.2-0.70.30.40.30.30.1-0.40.4-0.1-0.40.1-0.40.30.4
Time in open arm after self-admin1.51.72.31.11.51.41.3-1.41.41.41.31.31.1-1.41.3-0.9-1.40.9-1.31.31.4
Bone: periosteal estimation1.22.52.91.61.71.61.7-1.61.61.71.61.61.6-1.61.6-1.3-1.61.3-1.61.51.6
Bone: periosteal perimeter0.50.91.10.91.00.91.0-1.01.01.01.01.00.9-1.01.0-0.7-1.00.7-1.01.01.0
Bone: post-yield work0.91.31.71.21.11.01.1-0.81.11.11.11.11.3-1.11.1-1.3-1.11.3-1.11.21.1
Progressive ratio test 1 active lever presses1.31.63.21.40.51.31.3-1.81.21.11.21.11.4-1.11.1-1.5-1.11.5-1.21.21.2
Progressive ratio test 1 breakpoint1.31.63.41.40.51.31.3-1.81.21.11.21.11.4-1.11.2-1.5-1.11.5-1.21.21.3
Progressive ratio test 1 inactive lever presses2.73.87.52.71.72.02.2-1.82.02.01.92.02.1-1.81.7-2.2-1.72.2-1.71.61.7
Progressive ratio test 2 active lever presses0.20.20.90.9-0.10.30.5-0.50.30.40.30.40.7-0.20.2-0.7-0.20.7-0.20.30.2
Progressive ratio test 2 breakpoint0.10.10.70.8-0.20.20.4-0.40.30.30.20.30.6-0.10.1-0.6-0.10.6-0.10.20.1
Progressive ratio test 2 inactive lever presses1.21.96.62.61.01.31.6-1.01.41.41.31.51.6-1.11.0-1.5-0.91.5-0.90.91.0
ShA PR total presses1.92.22.61.31.31.51.5-1.41.51.41.51.41.5-1.51.5-1.6-1.51.6-1.51.61.6
Incentive Sensitization - Responses0.10.10.60.80.20.10.20.00.30.50.30.50.4-0.20.1-0.4-0.10.4-0.00.1-0.0
Incentive Sensitization - Breakpoint0.10.10.60.80.2-0.00.20.20.20.40.20.40.2-0.0-0.0-0.20.10.20.1-0.1-0.2
LgA PR total presses0.90.91.80.10.51.00.7-1.40.90.80.90.80.9-1.01.1-0.8-1.20.8-1.21.31.3
Sum of active levers in priming session hrs 5-60.70.61.30.31.11.00.7-1.10.90.80.80.80.3-0.90.9-0.3-0.90.3-0.90.70.7
Progressive ratio0.10.10.50.7-0.2-0.20.00.3-0.1-0.1-0.2-0.1-0.00.3-0.40.00.4-0.00.5-0.6-0.5
Food seeking constrained by brief footshock3.24.07.12.71.92.12.0-2.11.91.91.92.02.1-1.81.8-2.3-1.72.3-1.71.71.7
Seeking ratio, punishment vs. effort0.40.60.90.20.80.80.6-1.00.70.70.70.70.5-0.80.8-0.7-0.90.7-0.90.90.9
Retroperitoneal fat weight22.093.897.4-9.1-9.8-9.8-9.79.9-9.8-9.7-9.8-9.7-9.69.8-9.89.59.8-9.59.8-9.7-9.7
Reaction time number correct0.50.91.80.81.31.00.9-1.10.91.01.01.00.9-1.01.0-0.8-1.00.8-1.00.90.9
Reaction time mean minus median0.00.00.00.1-0.1-0.0-0.10.1-0.1-0.1-0.1-0.10.00.1-0.1-0.20.20.20.1-0.1-0.0
Reaction time mean minus median AUC0.00.10.1-0.3-0.3-0.2-0.30.3-0.4-0.3-0.3-0.3-0.20.3-0.30.10.3-0.10.3-0.2-0.2
Reaction time num false alarms0.00.10.3-0.40.40.30.1-0.60.20.00.1-0.0-0.1-0.20.20.2-0.3-0.2-0.30.30.2
Reaction time num false alarms AUC0.10.10.5-0.50.50.40.1-0.70.20.10.10.0-0.1-0.30.30.2-0.4-0.2-0.40.40.2
Reaction time trials correct on left0.50.91.80.81.31.00.9-1.10.91.01.01.00.9-1.01.0-0.8-1.00.8-1.00.90.9
Reaction time trials on left0.51.01.90.81.41.11.0-1.11.01.01.01.00.9-1.01.0-0.8-1.00.8-1.01.00.9
Reaction time mean1.11.82.0-1.3-1.2-1.2-1.31.1-1.3-1.4-1.4-1.4-1.41.3-1.41.41.4-1.41.4-1.4-1.3
Reaction time mean AUC0.91.51.7-1.2-1.1-1.0-1.21.0-1.2-1.3-1.2-1.3-1.31.2-1.21.31.2-1.31.2-1.3-1.2
Median of all reaction times1.41.92.4-1.4-1.3-1.2-1.41.1-1.4-1.5-1.4-1.5-1.51.4-1.41.51.4-1.51.4-1.5-1.4
Reaction time omissions0.10.10.20.30.40.40.3-0.30.30.30.30.30.3-0.30.3-0.2-0.30.2-0.30.30.2
Reaction time false alarm rate0.10.10.7-0.8-0.1-0.1-0.4-0.2-0.3-0.4-0.3-0.5-0.50.2-0.20.50.2-0.50.1-0.2-0.2
Reaction time premature initiation rate0.20.20.5-0.6-0.7-0.4-0.50.3-0.5-0.4-0.5-0.5-0.40.5-0.50.50.5-0.50.4-0.4-0.4
Reaction time premature initiations0.00.00.1-0.1-0.00.2-0.0-0.20.10.10.00.10.1-0.10.10.0-0.1-0.0-0.10.20.1
Std. dev. reaction times0.30.50.6-0.5-0.5-0.5-0.60.7-0.7-0.7-0.7-0.8-0.70.7-0.80.60.8-0.60.8-0.7-0.7
Reaction time trials completed0.51.01.90.81.41.11.0-1.11.01.01.01.00.9-1.01.0-0.8-1.00.8-1.01.00.9
Reaction time trials AUC0.61.22.20.91.51.21.1-1.21.11.11.11.11.0-1.11.1-0.9-1.10.9-1.11.11.0
Run reversals in cocaine runway, females0.10.10.4-0.6-0.3-0.2-0.30.1-0.2-0.3-0.3-0.3-0.40.2-0.20.20.1-0.20.1-0.1-0.2
Run reversals in cocaine runway, males0.10.10.4-0.60.10.00.0-0.20.10.00.10.10.1-0.20.3-0.3-0.40.3-0.40.40.4
Latency to leave start box in cocaine runway0.50.60.90.90.50.70.7-0.80.70.70.80.80.9-0.70.7-0.9-0.70.9-0.70.70.7
Latency to leave start box in cocaine runway, F0.30.30.80.30.30.70.4-0.90.50.40.50.50.5-0.60.6-0.5-0.60.5-0.60.60.5
Latency to leave start box in cocaine runway, M0.10.10.60.8-0.0-0.10.20.40.00.20.20.40.4-0.00.0-0.40.10.40.1-0.0-0.0
Std. dev. time between licks in bursts0.10.10.4-0.0-0.0-0.1-0.20.3-0.1-0.1-0.2-0.1-0.40.2-0.20.60.2-0.60.3-0.4-0.3
Total sessions with >9 infusions0.60.71.91.40.20.60.9-0.80.60.80.70.81.3-0.60.6-1.3-0.51.3-0.60.70.6
Short access day 1 total inactive lever presses7.49.713.63.73.53.43.4-3.43.23.13.13.13.0-3.13.0-2.9-2.92.9-2.92.82.7
Short access day 10 total inactive lever presses1.74.15.32.12.32.32.2-1.92.12.02.11.91.9-2.12.0-1.9-2.01.9-2.01.91.9
Short access day 1 total infusions3.44.59.43.11.71.92.3-1.91.92.22.12.12.6-1.81.8-2.6-1.72.6-1.71.81.7
Short access day 10 total infusions1.92.43.91.71.31.61.6-2.01.51.51.51.51.7-1.51.5-1.7-1.51.7-1.51.51.4
Short access total infusions1.01.23.01.70.60.91.2-1.10.91.11.01.11.5-0.90.9-1.5-0.81.5-0.80.90.8
ShA early post infusion interval0.20.20.4-0.2-0.0-0.4-0.30.3-0.3-0.3-0.4-0.3-0.40.4-0.40.60.5-0.60.5-0.5-0.4
ShA late post infusion interval2.72.74.1-1.0-1.8-1.8-1.52.0-1.7-1.6-1.6-1.5-1.41.7-1.71.71.8-1.71.8-1.8-1.7
ShA early loading0.30.30.7-0.00.50.60.5-0.80.50.40.40.40.3-0.50.6-0.5-0.60.5-0.60.60.7
ShA late loading0.71.01.20.80.81.00.9-1.01.00.91.01.00.9-1.01.0-1.0-1.01.0-1.01.11.1
Short access day 1 locomotion2.42.95.42.31.01.51.8-1.51.61.81.71.72.2-1.51.5-2.1-1.42.1-1.51.61.5
Short access day 10 total locomotion1.01.92.51.51.11.61.5-1.31.41.31.41.31.4-1.41.4-1.3-1.31.3-1.41.31.4
Short access total locomotion0.10.10.40.7-0.10.30.4-0.30.20.30.30.20.6-0.20.2-0.6-0.20.6-0.20.30.2
ShA early average infusions1.31.52.61.20.61.31.2-1.41.11.01.11.01.4-1.11.1-1.6-1.11.6-1.21.31.2
ShA late average infusions2.42.54.02.01.21.61.6-1.41.51.51.61.51.7-1.51.4-1.9-1.41.9-1.41.51.5
ShA early timeout0.40.40.60.60.30.70.7-0.70.60.50.60.50.7-0.60.6-0.8-0.60.8-0.60.70.7
ShA late timeout1.81.93.51.51.11.41.4-1.11.31.31.31.31.5-1.31.3-1.9-1.31.9-1.31.41.3
ShA early titration0.20.20.40.40.20.60.5-0.60.30.20.40.20.5-0.40.4-0.6-0.40.6-0.40.50.4
ShA late titration2.12.23.71.91.41.51.6-1.31.51.51.51.51.5-1.41.4-1.7-1.41.7-1.31.41.4
ShA total infusions1.01.22.01.30.91.11.1-1.21.11.01.11.01.1-1.01.0-1.4-1.01.4-1.01.01.0
One hour access (0.3 mA shock)1.11.22.91.71.11.01.2-1.01.11.21.11.21.2-1.00.9-1.3-0.91.3-0.80.81.0
Shock compulsivity0.51.01.51.00.71.21.1-1.21.00.81.00.91.0-1.11.1-0.8-1.10.8-1.11.01.1
Compulsive drug intake0.70.93.0-1.70.1-0.8-1.00.7-0.8-0.9-0.9-0.9-1.30.7-0.61.20.6-1.20.6-0.7-0.8
One hour access (shock baseline)1.42.24.32.10.91.31.5-1.41.41.61.41.61.7-1.31.3-1.7-1.21.7-1.21.31.4
Social response proportion0.30.40.8-0.1-0.9-0.6-0.50.5-0.7-0.7-0.6-0.6-0.40.7-0.70.40.7-0.40.7-0.6-0.5
Social responses0.10.10.20.1-0.4-0.1-0.20.1-0.3-0.3-0.3-0.2-0.30.3-0.30.40.4-0.40.4-0.4-0.2
Social time0.50.61.20.4-0.8-0.6-0.50.9-0.7-0.7-0.7-0.6-0.50.9-0.90.61.0-0.61.1-1.1-1.1
Soleus weight4.814.015.63.13.73.93.7-3.93.83.73.83.73.6-3.93.9-3.5-3.93.5-3.93.93.9
Bone: stiffness0.00.00.10.20.30.10.2-0.10.20.20.20.30.1-0.20.20.2-0.2-0.2-0.10.10.2
Tibialis anterior weight3.813.014.03.33.63.73.6-3.73.73.73.63.63.6-3.73.7-3.3-3.73.3-3.73.73.7
Time to tail flick, vehicle, before self-admin1.31.32.5-0.9-1.6-1.3-1.21.1-1.2-1.2-1.2-1.2-0.91.3-1.20.61.3-0.61.2-1.1-1.2
Time to tail flick, vehicle, after self-admin3.64.86.5-2.2-2.6-2.3-2.32.3-2.4-2.4-2.3-2.3-1.82.3-2.21.62.2-1.62.2-1.9-2.1
Time to tail flick, test, before self-admin0.10.10.20.1-0.10.20.2-0.50.20.10.20.10.3-0.20.2-0.3-0.20.3-0.30.30.2
Time to tail flick, test, after self-admin0.10.10.30.3-0.10.40.3-0.50.30.10.30.20.3-0.30.3-0.5-0.30.5-0.30.30.3
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.2-0.2-0.3-0.20.4-0.3-0.3-0.2-0.2-0.10.2-0.20.10.2-0.10.2-0.1-0.2
Delta time to tail flick, test, before/after SA1.61.72.01.31.41.41.3-1.31.31.31.31.31.2-1.31.3-1.2-1.31.2-1.31.21.3
Tibia length2.77.38.4-2.2-2.5-2.7-2.62.8-2.7-2.6-2.7-2.6-2.72.8-2.82.82.8-2.82.8-2.9-2.9
Ambulatory time before self-admin0.00.00.1-0.10.20.10.10.10.10.20.10.1-0.0-0.10.20.3-0.2-0.3-0.20.20.2
Ambulatory time after self-admin1.31.52.4-1.1-0.6-1.4-1.11.5-1.1-0.9-1.1-1.0-1.41.1-1.11.61.1-1.61.2-1.3-1.3
Bone: tissue strength1.01.01.9-1.4-0.9-1.0-1.11.0-1.0-1.0-1.0-1.0-1.10.9-0.91.00.8-1.00.8-0.8-0.8
Total heroin consumption3.13.75.11.51.72.01.8-2.32.02.01.91.91.8-2.02.0-1.8-2.01.8-2.01.91.9
Total infusions0.10.10.5-0.2-0.7-0.2-0.30.0-0.3-0.3-0.3-0.3-0.20.3-0.30.30.3-0.30.3-0.2-0.2
Bone: trabecular number3.86.38.02.42.82.72.6-2.62.62.62.52.52.3-2.62.5-2.3-2.52.3-2.52.42.4
Bone: trabecular spacing3.54.66.3-2.5-2.2-2.2-2.22.1-2.1-2.2-2.1-2.1-2.22.1-2.02.22.0-2.22.0-2.0-2.0
Bone: trabecular thickness0.91.21.81.31.31.11.1-1.11.11.11.11.11.1-1.01.0-1.1-1.01.1-1.00.90.9
Bone: trabecular tissue density0.30.40.70.80.90.60.7-0.60.70.80.70.80.5-0.70.6-0.5-0.60.5-0.60.60.6
Water consumed over 24 hours0.60.81.30.71.11.00.9-1.11.01.00.90.90.7-0.90.9-0.5-0.90.5-0.90.90.9
Number of responses in last shaping day0.20.31.71.3-0.6-0.10.40.30.30.40.30.40.8-0.10.1-0.70.00.70.00.10.2