Hub : Genes

Gpn1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Gpn1 0.65 0.15 2.4e-07 0.16 0.27 0.27 0.2 4.8e-05 8.3e-08 8.7e-08 3.5e-06
2 Brain gene expression Gpn1 0.32 0.08 0.0e+00 0.36 0.35 0.34 0.35 2.2e-34 1.7e-33 9.3e-33 3.9e-34
3 BLA gene expression Gpn1 0.32 0.14 5.0e-16 0.25 0.26 0.27 0.27 8.1e-14 2.7e-14 1.5e-14 9.3e-15
4 pVTA gene expression Gpn1 0.33 0.15 0.0e+00 0.34 0.37 0.36 0.37 1.1e-15 8.5e-17 1.7e-16 4.1e-17
5 PL gene expression Gpn1 0.18 0.04 0.0e+00 0.35 0.35 0.35 0.35 7.2e-40 6.6e-40 7.4e-40 7.5e-40
6 OFC gene expression Gpn1 0.37 0.23 1.1e-06 0.19 0.22 0.2 0.21 2.4e-05 6.2e-06 2.0e-05 8.0e-06
7 PL mRNA stability Gpn1 0.07 0.04 2.2e-11 0.1 0.1 0.1 0.1 6.0e-11 5.6e-11 9.6e-11 3.6e-11
8 NAcc gene expression Gpn1 0.33 0 0.0e+00 0.24 0.25 0.24 0.25 1.6e-27 5.1e-29 5.7e-28 2.8e-29
9 Adipose mRNA stability Gpn1 0.02 0.03 8.5e-03 0.01 0.01 0.01 0.01 1.3e-02 3.7e-02 1.6e-02 2.9e-02
10 Adipose gene expression Gpn1 0.68 0.27 0.0e+00 0.43 0.43 0.43 0.43 5.4e-52 1.5e-51 8.6e-52 3.9e-52
11 IL gene expression Gpn1 0.53 0.21 8.0e-10 0.18 0.22 0.18 0.19 4.3e-05 5.0e-06 4.1e-05 3.1e-05
12 Brain mRNA stability Gpn1 0.05 0.04 2.6e-04 0.02 0.03 0.02 0.02 2.8e-03 1.1e-03 1.1e-02 4.2e-03
13 Liver gene expression Gpn1 0.47 0.23 0.0e+00 0.34 0.35 0.35 0.35 2.7e-39 4.6e-40 6.1e-40 1.6e-40
14 Liver mRNA stability Gpn1 0.04 0.04 2.0e-04 0.03 0.02 0.02 0.02 7.0e-04 1.2e-03 1.0e-03 1.3e-03
15 NAcc mRNA stability Gpn1 0.06 0.05 1.9e-08 0.08 0.07 0.07 0.07 2.7e-09 1.2e-08 8.7e-09 5.7e-09
16 LHb gene expression Gpn1 0.39 0.23 4.6e-07 0.22 0.25 0.29 0.22 5.7e-06 1.2e-06 1.4e-07 4.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density5.49.010.42.9-3.13.13.13.13.1-3.13.0-3.23.13.0-3.03.03.03.0-2.2
Area under the delay curve0.40.52.9-1.1-0.20.10.0-0.10.1-0.20.10.30.20.3-0.51.10.90.8-1.7
BMI with tail0.41.42.5-1.01.2-1.3-1.1-1.0-1.11.2-1.21.6-1.4-1.11.1-1.2-1.2-1.10.3
BMI without tail0.20.50.9-0.20.8-0.8-0.7-0.5-0.60.6-0.60.8-0.7-0.70.8-0.9-0.9-0.80.3
Body weight1.87.69.2-2.63.0-3.0-2.9-2.7-2.82.9-2.82.6-2.7-2.82.8-2.7-2.8-2.82.1
Weight adjusted by age0.00.10.40.6-0.30.20.00.10.00.1-0.10.2-0.1-0.00.1-0.4-0.1-0.10.2
Bone surface2.85.06.32.4-2.32.32.32.42.3-2.32.3-2.52.32.2-2.22.12.02.0-1.7
Bone volume3.05.16.92.4-2.42.32.32.42.3-2.32.3-2.62.42.2-2.22.12.12.1-1.6
Breakpoint value in progressive ratio session1.11.22.20.7-1.01.11.00.91.0-1.01.1-1.51.41.1-1.11.01.31.3-0.1
Number of licking bursts0.10.21.0-0.2-0.30.30.30.20.3-0.20.3-0.10.20.3-0.40.60.50.5-1.0
Context. condit. distance diff. score0.00.00.0-0.10.0-0.2-0.0-0.1-0.10.0-0.1-0.10.0-0.10.1-0.0-0.1-0.10.2
Locomotion velocity, session 10.00.10.20.4-0.1-0.10.00.1-0.00.0-0.10.4-0.3-0.10.2-0.3-0.3-0.3-0.2
Locomotion distance, session 12.12.74.41.5-1.71.61.71.71.7-1.71.7-1.31.51.6-1.61.61.61.6-2.1
Locomotion velocity, session 20.20.20.4-0.60.5-0.5-0.5-0.5-0.50.5-0.50.5-0.5-0.40.4-0.4-0.4-0.40.1
Locomotion distance, session 20.00.00.10.3-0.10.10.10.10.1-0.10.00.0-0.00.00.0-0.1-0.1-0.1-0.4
Locomotion velocity, session 30.50.60.91.0-0.80.80.80.90.8-0.90.8-0.80.80.8-0.80.70.70.7-0.3
Locomotion distance, session 30.91.01.21.1-1.11.11.11.11.0-1.11.1-0.80.91.0-1.00.91.01.0-1.0
Stereotopy head waving bouts, day 31.72.02.51.6-1.51.51.41.51.5-1.51.5-1.21.41.4-1.41.31.31.3-1.1
Stereotopy head waving duration, day 30.10.10.20.4-0.30.30.30.30.3-0.30.3-0.20.30.3-0.30.30.30.3-0.3
Locomotion velocity, session 71.11.22.41.6-1.21.11.11.21.1-1.21.1-1.31.21.0-1.00.90.80.8-0.6
Locomotion distance, session 70.10.10.60.8-0.40.20.30.40.3-0.30.2-0.50.30.2-0.10.0-0.1-0.1-0.2
Stereotopy head waving bouts, day 70.00.10.3-0.30.2-0.1-0.1-0.2-0.10.1-0.10.6-0.3-0.10.1-0.1-0.0-0.0-0.4
Stereotopy head waving duration, day 70.30.30.40.5-0.50.70.60.60.6-0.60.6-0.40.60.6-0.60.60.70.7-0.6
Locomotion velocity, session 80.20.31.51.2-0.50.50.50.60.5-0.50.4-0.70.60.4-0.2-0.0-0.0-0.00.0
Locomotion distance, session 80.40.51.10.9-0.80.60.80.80.7-0.80.7-0.70.70.7-0.60.70.60.6-1.0
Degree of sensitization distance0.80.81.0-0.70.9-1.0-0.9-0.9-0.90.9-1.00.7-0.8-0.91.0-1.0-1.0-1.00.7
Degree of sensitization stereotypy0.20.20.6-0.70.5-0.4-0.4-0.5-0.40.4-0.40.8-0.5-0.40.3-0.3-0.2-0.2-0.2
Conditioned locomotion3.13.64.01.6-1.81.91.91.91.9-1.91.9-1.92.02.0-2.02.02.02.0-1.6
Cocaine response after cond. corrected1.01.22.20.5-1.00.91.10.91.1-1.01.1-0.70.91.1-1.21.21.31.3-1.5
Cocaine response after cond. not corrected2.12.33.20.9-1.51.41.61.41.5-1.51.6-1.21.41.6-1.71.71.81.8-1.8
Cocaine response before conditioning1.11.31.81.3-1.31.31.11.21.2-1.21.1-1.11.11.1-1.11.01.11.1-0.6
Saline control response0.71.01.71.3-1.11.01.01.11.0-1.01.0-1.11.01.0-0.90.80.70.7-0.8
Bone: connectivity density5.28.19.22.6-2.92.92.92.92.9-2.92.9-3.02.92.9-2.92.82.92.9-2.0
Bone: cortical apparent density0.40.51.10.4-0.70.70.70.60.7-0.70.7-0.70.70.7-0.70.90.70.7-1.0
Bone: cortical area0.40.51.10.8-0.80.70.70.80.7-0.70.7-1.10.80.7-0.70.70.60.6-0.5
Bone: cortical porosity1.31.52.71.4-1.21.31.21.31.2-1.21.2-1.61.41.2-1.21.11.01.00.0
Bone: cortical porosity1.21.32.21.3-1.11.21.21.21.1-1.21.2-1.51.31.1-1.11.00.90.9-0.0
Bone: cortical thickness0.00.00.0-0.20.1-0.2-0.1-0.1-0.10.1-0.2-0.1-0.1-0.20.1-0.1-0.2-0.20.0
Bone: cortical thickness1.61.92.01.3-1.31.41.41.41.4-1.41.4-1.41.41.4-1.41.31.41.4-1.2
Bone: cortical tissue density0.30.40.90.3-0.60.60.60.50.6-0.60.6-0.60.60.6-0.60.80.60.6-1.0
Condit. Reinf. active minus inactive responses0.60.61.2-1.10.8-0.8-0.8-0.9-0.80.8-0.81.0-0.9-0.80.7-0.6-0.6-0.60.3
Condit. Reinf. active-inactive response ratio0.70.81.6-1.30.9-0.9-0.9-1.0-0.90.9-0.90.9-0.9-0.80.8-0.6-0.6-0.60.9
Condit. Reinf. active responses0.20.31.3-0.0-0.40.40.40.30.4-0.40.5-0.10.30.5-0.60.70.70.7-1.2
Condit. Reinf. inactive responses1.92.34.91.3-1.51.51.51.51.5-1.51.5-1.01.31.5-1.51.51.51.5-2.2
Incentive salience index mean0.00.00.1-0.2-0.20.20.10.00.1-0.10.1-0.00.10.2-0.20.30.30.3-0.3
Condit. Reinf. lever presses0.60.91.30.4-0.90.90.90.80.9-0.90.9-0.70.80.9-1.01.11.11.1-1.1
Condit. Reinf. active minus inactive responses3.74.65.61.8-2.22.22.22.12.2-2.22.2-1.82.12.2-2.32.42.32.3-2.0
Condit. Reinf. active-inactive response ratio1.01.12.10.8-1.01.01.11.01.0-1.01.1-0.50.91.1-1.11.21.11.1-1.4
Condit. Reinf. active responses3.04.14.91.8-2.12.22.02.02.0-2.02.0-1.82.12.1-2.12.22.22.2-1.5
Condit. Reinf. inactive responses1.72.12.71.2-1.51.61.41.41.4-1.41.4-1.61.61.5-1.51.51.61.6-0.6
Condit. Reinf. lever presses2.02.83.71.3-1.61.61.71.61.7-1.61.7-1.31.61.7-1.71.81.81.8-1.9
Condit. Reinf. lever reinforcers received2.63.64.21.7-2.02.11.91.81.9-1.91.9-1.71.92.0-2.02.02.02.0-1.4
Conditioned reinforcement - actives1.01.03.92.0-0.70.90.91.31.0-1.01.0-1.51.20.9-0.60.40.30.30.3
Conditioned reinforcement - inactives3.13.57.32.7-2.42.12.22.02.0-1.91.9-1.81.71.8-1.71.31.41.3-0.8
Conditioned locomotion0.30.42.61.6-0.00.30.20.60.2-0.20.2-0.80.50.10.2-0.6-0.7-0.70.7
Patch foraging indifference point 0 sec0.40.72.4-0.70.8-0.6-0.9-0.8-0.80.9-0.90.3-0.6-0.80.8-0.8-0.7-0.81.6
Patch foraging indifference point AUC2.42.84.62.2-1.61.71.71.91.8-1.81.8-2.01.81.6-1.51.41.41.4-0.9
Delay disc. indifference point, 0s delay2.62.97.2-2.71.7-1.8-1.9-2.0-1.81.8-1.72.2-1.7-1.61.5-0.7-1.2-1.2-0.4
Delay disc. indifference point, 16s delay0.60.63.1-0.8-0.40.30.30.20.4-0.40.50.10.40.6-0.81.21.21.2-1.8
Delay disc. indifference point, 2s delay0.20.30.6-0.70.4-0.6-0.5-0.5-0.50.5-0.50.8-0.5-0.50.4-0.2-0.3-0.4-0.5
Delay disc. indifference point, 24s delay2.32.26.4-0.9-0.91.00.90.61.0-1.11.1-0.61.21.4-1.72.22.32.3-2.5
Delay disc. indifference point, 4s delay0.10.11.1-0.0-0.20.10.00.10.1-0.20.10.30.00.1-0.10.40.20.1-1.0
Delay disc. indifference point, 8s delay0.40.41.7-1.0-0.20.20.1-0.10.2-0.20.3-0.10.40.4-0.61.10.90.9-1.3
Indifference point function ln k0.00.00.1-0.00.0-0.1-0.1-0.1-0.10.2-0.20.2-0.1-0.20.2-0.1-0.2-0.2-0.1
Indifference point function log k0.00.00.1-0.00.0-0.1-0.1-0.1-0.10.2-0.20.2-0.1-0.20.2-0.1-0.2-0.2-0.1
Patch foraging total patch changes 0 sec0.30.52.0-0.70.7-0.5-0.7-0.7-0.70.8-0.80.1-0.5-0.60.6-0.6-0.6-0.61.4
Patch foraging total patch changes 12 sec0.81.02.3-0.91.0-0.9-1.0-1.0-1.01.0-1.00.5-0.8-1.01.0-0.9-1.0-1.01.5
Patch foraging total patch changes 18 sec0.10.10.90.30.20.0-0.10.0-0.00.1-0.1-0.40.1-0.10.2-0.3-0.2-0.20.9
Patch foraging total patch changes 24 sec0.81.01.7-0.51.0-1.0-1.0-0.8-0.91.0-1.00.7-0.9-1.01.1-1.2-1.3-1.21.3
Patch foraging total patch changes 6 sec0.00.00.2-0.10.2-0.1-0.2-0.1-0.20.2-0.2-0.0-0.1-0.20.2-0.3-0.2-0.20.5
Patch foraging time to switch 0 sec0.10.20.8-0.80.0-0.2-0.1-0.3-0.10.1-0.10.8-0.30.0-0.10.40.30.3-0.9
Patch foraging water rate 0 sec0.10.20.90.80.00.2-0.00.30.1-0.1-0.0-0.80.3-0.00.2-0.5-0.3-0.31.0
Patch foraging water rate 12 sec1.62.53.2-1.41.6-1.6-1.6-1.6-1.61.6-1.51.2-1.5-1.61.6-1.8-1.6-1.61.6
Patch foraging water rate 18 sec0.60.91.2-0.70.8-0.9-0.9-0.9-0.90.9-0.90.8-0.9-0.91.0-1.1-1.0-1.00.9
Patch foraging water rate 24 sec2.13.04.3-2.02.1-1.8-1.8-1.8-1.81.8-1.71.2-1.5-1.71.7-1.6-1.5-1.61.7
Patch foraging water rate 6 sec1.31.92.6-1.21.4-1.4-1.4-1.3-1.41.3-1.31.2-1.4-1.41.4-1.6-1.5-1.41.4
Seeking ratio, delayed vs. immediate footshock0.20.20.70.9-0.0-0.2-0.00.2-0.00.0-0.1-0.2-0.1-0.20.4-0.5-0.7-0.70.8
Distance traveled before self-admin0.10.10.9-0.1-0.1-0.1-0.00.10.1-0.1-0.00.30.00.2-0.20.30.30.3-0.9
Distance traveled after self-admin0.80.91.7-1.21.1-1.2-1.0-0.9-0.90.9-0.91.3-1.1-0.80.8-0.9-0.6-0.6-0.0
Extensor digitorum longus weight4.417.419.03.8-4.24.34.24.24.3-4.24.3-4.34.44.3-4.34.34.34.3-3.2
Bone: elastic displacement0.70.81.40.5-0.81.00.80.80.9-0.80.9-1.21.10.9-1.01.11.11.1-0.2
Bone: elastic work1.01.31.80.8-1.11.21.11.01.1-1.11.2-1.21.21.2-1.21.31.31.3-0.8
Bone: endosteal estimation0.40.91.51.1-1.01.01.01.01.0-0.91.0-1.21.10.9-0.90.90.80.8-0.7
Bone: endosteal perimeter0.20.30.60.6-0.60.60.60.60.6-0.60.6-0.80.70.6-0.60.50.60.6-0.4
Epididymis fat weight14.734.237.6-5.56.1-5.9-6.1-5.9-6.06.0-6.05.0-5.5-5.96.0-5.9-6.0-5.95.5
Delta time in closed arm before/after self-admin0.00.00.3-0.10.2-0.2-0.2-0.2-0.20.2-0.10.0-0.1-0.20.2-0.3-0.1-0.10.5
Delta time in open arm before/after self-admin0.30.30.70.5-0.50.50.60.60.6-0.60.6-0.50.60.6-0.60.80.50.5-0.6
Diff in mean of infusions in LGA sessions0.20.30.90.5-0.40.60.50.50.5-0.50.5-0.90.70.5-0.50.40.30.30.4
Delay discount exponential model param0.60.73.40.80.5-0.4-0.3-0.1-0.40.4-0.40.0-0.5-0.60.8-1.3-1.2-1.11.8
Extinction: sum of active levers before priming0.50.50.80.1-0.70.70.60.50.6-0.60.6-0.60.70.7-0.80.90.90.9-0.8
Active lever presses in extinction session 60.30.31.11.0-0.50.50.50.60.5-0.50.4-1.00.80.5-0.40.20.20.20.2
Bone: final force0.10.20.80.7-0.50.40.40.50.5-0.50.4-0.90.70.4-0.40.40.30.3-0.2
Bone: final moment0.20.30.90.7-0.60.50.50.60.5-0.50.5-0.90.70.5-0.50.50.40.4-0.2
Food consumed during 24 hour testing period0.20.30.60.7-0.60.60.60.60.6-0.50.5-0.30.40.5-0.50.30.50.5-0.8
Glucose0.20.30.6-0.20.4-0.5-0.5-0.5-0.50.5-0.50.6-0.6-0.60.6-0.7-0.8-0.80.6
Heart weight9.313.116.4-2.83.4-3.6-3.6-3.4-3.53.6-3.73.7-3.9-3.73.7-3.9-4.1-4.03.0
Delay discount hyperbolic model param0.60.63.30.60.5-0.4-0.3-0.2-0.40.5-0.40.0-0.5-0.60.8-1.3-1.1-1.01.8
Intermittent access intake day 1-15 change0.20.21.41.2-0.30.30.50.70.4-0.60.6-0.20.20.3-0.1-0.1-0.0-0.1-0.6
Intermittent access intake escalation0.10.11.01.0-0.10.00.20.50.2-0.30.30.1-0.10.00.1-0.4-0.3-0.3-0.5
Intermittent access intake escalation 20.30.30.80.80.1-0.4-0.10.1-0.20.0-0.10.8-0.7-0.40.6-0.9-0.7-0.9-0.2
Intermitt. access day 1 inactive lever presses0.30.31.41.2-0.80.50.60.50.5-0.40.3-0.80.40.3-0.3-0.1-0.10.00.8
Intermitt. access day 15 inactive lever presses8.69.422.34.7-3.63.23.33.63.3-3.23.0-3.32.92.9-2.72.02.32.2-1.1
Intermitt. access escalation Index0.20.20.70.30.2-0.4-0.2-0.1-0.20.2-0.20.8-0.6-0.40.5-0.7-0.6-0.7-0.3
Intermittent access day 1 total infusions5.26.08.32.9-2.82.72.72.62.6-2.52.4-2.52.42.4-2.42.22.22.2-1.4
Intermittent access day 15 total infusions2.52.86.42.5-1.91.71.92.01.8-1.81.7-1.51.51.6-1.51.11.21.2-1.2
Intermittent access terminal intake (last 3 days)2.02.25.72.4-1.81.41.71.81.6-1.61.5-1.31.31.4-1.30.91.11.0-1.0
Intermittent access total infusions2.02.24.02.0-1.71.71.61.61.6-1.51.4-1.61.51.5-1.41.21.31.2-0.8
Intermittent access day 1 locomotion2.22.43.11.5-1.81.61.71.51.6-1.61.6-1.61.51.6-1.61.51.41.4-1.0
Intermittent access day 15 total locomotion0.80.92.11.5-1.21.01.11.00.9-1.01.0-0.80.80.8-0.80.50.60.5-0.7
Intermittent access total locomotion0.30.30.91.0-0.70.70.70.60.6-0.60.6-0.70.60.5-0.50.30.20.2-0.1
Intermittent access standard deviation0.30.31.31.1-0.70.50.50.50.4-0.50.4-0.80.50.3-0.20.1-0.00.10.5
Left kidney weight0.00.00.1-0.3-0.0-0.1-0.1-0.2-0.10.1-0.2-0.0-0.1-0.10.00.0-0.00.00.3
Right kidney weight1.02.85.8-2.41.7-1.7-1.7-2.0-1.81.8-1.81.7-1.7-1.71.5-1.3-1.4-1.31.1
Cocaine induced anxiety0.50.52.21.5-0.90.80.80.90.8-0.80.7-0.90.60.6-0.50.20.20.20.1
Post-drug Anxiety0.60.61.2-0.70.7-0.8-0.7-0.7-0.80.7-0.71.1-1.1-0.80.8-0.9-0.9-0.90.3
Baseline Anxiety1.61.74.4-2.11.5-1.4-1.3-1.4-1.31.3-1.21.8-1.4-1.11.0-0.7-0.8-0.8-0.2
Tail length0.10.41.0-0.40.8-0.6-0.6-0.5-0.60.5-0.50.0-0.3-0.60.7-0.8-0.6-0.61.0
Length with tail1.45.36.6-2.42.6-2.4-2.4-2.4-2.42.4-2.31.6-1.9-2.32.4-2.2-2.2-2.22.4
Length without tail0.61.41.9-1.31.2-1.3-1.2-1.3-1.21.3-1.30.8-1.0-1.21.2-1.0-1.1-1.11.4
Times rat made contact with spout2.12.53.81.1-1.51.51.51.41.5-1.51.5-2.01.81.6-1.71.71.81.8-1.0
Lifetime Intake2.83.26.02.4-2.02.01.91.91.9-1.81.7-2.01.91.8-1.71.41.51.5-0.7
Liver weight, left1.21.82.3-1.11.3-1.3-1.4-1.3-1.41.3-1.41.5-1.5-1.41.4-1.5-1.5-1.40.8
Liver weight, right8.614.316.4-3.43.8-3.9-3.8-3.7-3.83.8-3.94.0-4.1-3.93.9-4.0-3.9-3.82.5
Locomotor activity0.20.31.7-1.30.5-0.5-0.6-0.8-0.60.6-0.50.7-0.5-0.50.40.0-0.1-0.1-0.3
Locomotor testing distance0.10.20.7-0.4-0.40.40.30.10.3-0.30.4-0.20.40.4-0.50.80.70.7-0.7
Locomotor testing rearing0.60.91.30.8-0.81.00.90.90.9-0.90.9-1.01.11.0-1.01.01.01.0-0.6
Locomotion in novel chamber1.21.52.7-1.31.6-1.5-1.4-1.1-1.21.2-1.20.6-0.9-1.11.2-1.1-1.2-1.21.4
Locomotion in novel chamber post-restriction2.32.84.3-2.11.8-1.7-1.8-1.9-1.81.8-1.81.5-1.6-1.61.6-1.4-1.4-1.41.4
Fecal boli incidents, locomotor time 10.30.30.70.2-0.50.40.50.50.5-0.50.5-0.80.70.6-0.60.80.40.50.0
Change in fecal boli incidents, locomotor task4.44.24.8-2.22.2-2.1-2.1-2.2-2.12.2-2.11.8-1.9-2.12.0-2.0-1.9-1.91.9
Time >=10cm from walls, locomotor time 10.10.11.0-1.00.4-0.3-0.4-0.5-0.30.4-0.40.10.0-0.20.00.30.20.2-0.0
Bouts of movement, locomotor time 12.62.85.71.2-1.51.41.51.61.7-1.61.6-1.51.81.7-1.72.11.61.7-2.4
Total resting periods, locomotor time 12.83.14.81.5-1.71.61.71.81.8-1.71.7-1.61.91.8-1.82.11.61.7-2.2
Rest time, locomotor task time 10.00.10.20.4-0.20.30.20.30.2-0.20.1-0.40.30.2-0.20.10.00.00.2
Distance moved, locomotor task time 11.31.42.9-1.41.2-1.3-1.2-1.3-1.21.2-1.21.7-1.4-1.11.1-1.1-0.8-0.80.1
Vertical activity count, locomotor time 10.60.61.5-1.10.7-0.9-0.8-0.8-0.70.8-0.71.2-0.9-0.70.6-0.6-0.3-0.4-0.4
Time >=10cm from walls, locomotor time 20.10.20.70.8-0.30.40.30.40.3-0.40.2-0.70.60.3-0.20.10.10.0-0.1
Bouts of movement, locomotor time 20.10.10.3-0.40.4-0.5-0.3-0.2-0.30.2-0.30.4-0.3-0.30.3-0.2-0.4-0.4-0.4
Total resting periods, locomotor time 20.00.00.20.10.1-0.20.00.10.0-0.10.00.1-0.00.00.00.0-0.2-0.1-0.5
Rest time, locomotor task time 21.61.82.41.2-1.51.41.41.31.3-1.41.3-0.91.11.3-1.41.41.41.4-1.6
Distance moved, locomotor task time 21.01.21.6-0.81.2-1.1-1.2-1.0-1.11.1-1.21.1-1.1-1.11.2-1.3-1.0-1.10.6
Vertical activity count, locomotor time 20.60.61.1-0.30.8-0.8-0.8-0.7-0.80.8-0.80.4-0.5-0.80.9-1.1-0.9-1.00.9
Light reinforcement 14.37.89.32.8-3.02.82.92.92.9-2.92.9-2.32.52.8-2.92.72.82.8-2.7
Light reinforcement 24.05.37.02.4-2.62.32.62.42.4-2.42.5-1.51.82.3-2.32.12.22.1-2.6
Bone: marrow area0.51.01.51.1-1.01.01.01.01.0-1.01.0-1.21.11.0-0.90.90.90.9-0.7
Bone: maximum diameter0.91.72.31.3-1.31.31.31.31.3-1.31.3-1.51.41.3-1.31.31.31.3-1.0
Bone: maximum force0.00.10.30.4-0.20.20.10.20.2-0.20.1-0.60.30.1-0.10.1-0.0-0.00.1
Bone: maximum moment0.10.10.40.5-0.30.30.30.30.3-0.30.2-0.70.50.3-0.20.20.10.1-0.0
Mean time between licks in bursts2.43.43.7-1.91.8-1.9-1.9-1.9-1.91.9-1.91.9-1.9-1.91.8-1.8-1.8-1.81.4
Mean num. licks in bursts0.10.20.70.5-0.30.30.40.40.4-0.40.3-0.80.60.4-0.30.20.30.30.4
Cd content in liver0.00.00.60.0-0.10.00.00.10.1-0.10.00.10.10.1-0.10.20.00.0-0.8
Co content in liver5.56.47.52.2-2.62.62.62.52.6-2.52.5-2.32.52.6-2.62.72.62.6-2.4
Cu content in liver0.00.00.10.2-0.30.20.20.20.2-0.10.1-0.10.20.2-0.20.20.20.2-0.3
Fe content in liver0.10.10.70.20.1-0.2-0.1-0.1-0.10.1-0.2-0.0-0.1-0.20.2-0.3-0.3-0.30.9
K content in liver0.10.10.70.10.0-0.2-0.1-0.1-0.10.1-0.20.7-0.4-0.20.2-0.3-0.2-0.2-0.9
Mg content in liver0.10.10.3-0.20.2-0.4-0.3-0.3-0.30.3-0.40.4-0.4-0.40.4-0.5-0.4-0.40.1
Mn content in liver0.50.60.91.0-0.80.80.80.90.8-0.90.8-0.80.80.8-0.80.70.70.7-0.2
Na content in liver0.50.51.31.1-0.90.60.80.90.8-0.80.8-0.40.60.7-0.60.50.50.5-1.0
Rb content in liver0.00.00.0-0.00.0-0.2-0.1-0.1-0.10.1-0.10.1-0.1-0.10.1-0.1-0.1-0.10.1
Se content in liver0.30.40.7-0.10.5-0.6-0.6-0.5-0.60.6-0.60.5-0.6-0.70.8-0.9-0.9-0.90.7
Sr content in liver0.20.10.6-0.60.3-0.3-0.3-0.3-0.30.3-0.20.7-0.4-0.20.2-0.1-0.1-0.1-0.8
Zn content in liver1.21.41.6-1.11.1-1.3-1.2-1.2-1.21.3-1.21.1-1.1-1.21.2-1.2-1.2-1.20.6
Bone: minimum diameter0.10.20.7-0.10.3-0.3-0.3-0.3-0.30.4-0.4-0.4-0.1-0.40.4-0.5-0.5-0.50.8
Time in familiar zone, hab. session 10.70.71.0-0.40.7-0.8-0.8-0.7-0.80.8-0.90.6-0.7-0.80.9-0.9-1.0-1.00.8
Time in novel zone, hab. session 10.80.71.2-0.90.9-0.9-0.8-0.9-0.90.9-0.80.7-0.8-0.80.8-0.8-0.8-0.81.1
Total zone transitions, hab. session 10.10.20.90.3-0.40.30.30.40.4-0.40.3-0.30.40.4-0.40.40.40.4-0.9
Total locomotion distance, hab. session 10.20.30.90.7-0.50.50.50.60.5-0.50.4-0.40.40.4-0.40.30.30.3-0.9
Locomotion velocity, hab. session 11.11.63.31.2-1.31.21.31.31.3-1.31.2-0.91.11.2-1.21.11.21.2-1.8
Time in familiar zone, hab. session 20.00.00.20.4-0.10.10.10.20.1-0.10.1-0.20.10.1-0.0-0.1-0.1-0.10.1
Time in novel zone, hab. session 20.60.61.2-1.10.9-0.8-0.8-0.9-0.80.8-0.70.8-0.7-0.70.7-0.5-0.6-0.60.5
Total zone transitions, hab. session 20.10.20.60.1-0.30.30.40.30.4-0.30.4-0.30.40.4-0.40.50.50.5-0.8
Total locomotion distance, hab. session 20.30.30.50.5-0.60.60.60.60.6-0.60.6-0.70.60.6-0.60.50.60.6-0.6
Locomotion velocity, hab. session 20.50.60.80.7-0.80.80.80.80.8-0.80.8-0.90.90.8-0.80.80.80.8-0.8
Novel to familiar place preference ratio1.11.12.2-1.41.1-1.1-1.0-1.2-1.11.1-1.01.5-1.2-1.00.9-0.8-0.8-0.80.1
Novelty place preference1.71.72.8-1.71.4-1.4-1.3-1.4-1.41.3-1.31.7-1.5-1.31.2-1.1-1.1-1.10.5
Time in novel zone, NPP test2.02.03.1-1.71.5-1.5-1.4-1.5-1.51.5-1.41.8-1.6-1.41.3-1.2-1.2-1.20.7
Total zone transitions, NPP test1.52.13.01.3-1.51.41.41.51.5-1.51.4-1.11.31.5-1.51.51.51.5-1.7
Total locomotion distance, NPP test1.92.72.91.6-1.71.71.71.71.7-1.71.7-1.41.51.7-1.71.61.61.6-1.6
Locomotion velocity, NPP test3.34.75.02.0-2.22.22.22.22.2-2.22.2-1.92.12.2-2.22.22.22.2-2.2
Intraocular pressure5.27.212.4-3.52.9-2.8-2.8-3.0-2.82.8-2.82.6-2.7-2.72.5-2.3-2.2-2.21.9
Delta distance traveled before/after self-admin1.41.52.2-0.81.3-1.3-1.2-1.1-1.21.2-1.11.3-1.4-1.21.3-1.5-1.3-1.31.0
Delta ambulatory time before/after self-admin0.20.30.5-0.20.6-0.6-0.5-0.3-0.40.5-0.40.6-0.6-0.50.6-0.7-0.6-0.60.3
Parametrial fat weight5.410.612.1-3.13.3-3.5-3.3-3.2-3.33.3-3.33.2-3.4-3.33.3-3.2-3.3-3.32.3
Pavlov. Cond. lever latency1.92.43.1-1.61.7-1.6-1.6-1.6-1.61.6-1.51.8-1.6-1.51.5-1.5-1.4-1.40.8
Pavlov. Cond. magazine entry latency0.00.00.10.3-0.20.20.20.20.2-0.20.1-0.30.20.2-0.10.10.10.10.0
Pavlov. Cond. change in total contacts0.10.10.10.2-0.30.30.20.20.2-0.20.2-0.30.20.2-0.20.30.20.2-0.1
Pavlov. Cond. index score0.81.01.31.1-1.11.01.01.01.0-1.01.0-1.21.01.0-1.01.00.90.9-0.6
Pavlov. Cond. latency score0.81.01.41.1-1.11.01.01.01.0-1.00.9-1.21.01.0-1.00.90.90.9-0.5
Pavlov. Cond. lever contacts1.21.41.71.0-1.21.21.21.11.2-1.21.1-1.31.21.2-1.21.21.21.2-0.7
Pavlov. Cond. magazine entry number0.50.60.9-0.90.9-0.8-0.8-0.8-0.80.8-0.70.9-0.8-0.80.7-0.7-0.7-0.70.4
Pavlov. Cond. intertrial magazine entries1.21.41.80.8-1.11.21.21.11.2-1.21.2-1.11.21.2-1.31.31.41.4-1.1
Pavlov. Cond. lever-magazine prob. diff.1.62.02.41.3-1.51.51.41.41.5-1.41.4-1.51.51.4-1.51.51.41.4-0.9
Pavlov. Cond. response bias1.51.82.11.4-1.51.41.41.41.4-1.41.3-1.41.41.4-1.41.41.31.3-0.8
Pavlov. Cond. lever latency1.82.54.3-1.51.6-1.5-1.6-1.6-1.61.6-1.61.1-1.5-1.61.6-1.6-1.6-1.62.1
Pavlov. Cond. magazine entry latency0.40.41.21.1-0.80.70.70.80.7-0.70.7-0.20.40.6-0.50.30.30.3-0.9
Pavlov. Cond. change in total contacts0.71.01.60.8-1.01.01.00.91.0-1.01.0-0.81.01.0-1.01.01.01.0-1.3
Pavlov. Cond. index score1.21.52.71.4-1.41.31.31.31.3-1.31.3-0.91.11.2-1.21.01.11.1-1.6
Pavlov. Cond. latency score1.21.52.61.5-1.41.21.31.31.2-1.31.3-0.91.11.2-1.11.01.01.0-1.6
Pavlov. Cond. lever contacts1.01.32.80.9-1.11.11.11.11.1-1.11.1-0.81.01.1-1.21.21.21.2-1.7
Pavlov. Cond. magazine entry number0.20.20.5-0.70.5-0.4-0.5-0.5-0.40.4-0.50.2-0.3-0.40.3-0.1-0.2-0.20.7
Pavlov. Cond. intertrial magazine entries3.44.55.9-2.42.3-2.2-2.2-2.3-2.22.2-2.22.0-2.1-2.12.1-1.8-1.9-1.91.7
Pavlov. Cond. lever-magazine prob. diff.0.91.12.11.3-1.21.11.11.11.1-1.11.1-0.80.91.0-1.00.80.90.9-1.4
Pavlov. Cond. response bias1.82.44.51.4-1.61.51.61.61.6-1.61.6-1.01.41.6-1.61.51.61.6-2.1
Time in closed arm before self-admin0.50.61.5-0.50.6-0.7-0.7-0.7-0.80.7-0.80.2-0.5-0.70.8-0.8-0.9-0.91.2
Time in closed arm after self-admin1.61.63.6-1.21.2-1.2-1.3-1.3-1.31.3-1.30.6-0.9-1.31.3-1.3-1.2-1.21.9
Time in open arm before self-admin0.10.10.7-0.6-0.10.20.2-0.00.1-0.10.20.4-0.20.2-0.30.40.50.5-0.9
Time in open arm after self-admin2.22.54.31.1-1.61.51.71.51.6-1.61.6-0.91.21.6-1.71.81.61.6-2.1
Bone: periosteal estimation0.71.42.31.2-1.21.11.21.21.2-1.11.1-1.51.31.1-1.11.11.01.0-0.7
Bone: periosteal perimeter0.20.40.70.5-0.60.60.60.60.6-0.60.6-0.80.70.6-0.60.60.60.6-0.5
Bone: post-yield work0.40.61.40.9-0.80.80.70.80.8-0.80.7-1.21.00.8-0.70.70.60.6-0.1
Progressive ratio test 1 active lever presses1.41.54.62.1-1.41.51.31.31.2-1.11.1-1.61.31.1-0.90.60.60.70.3
Progressive ratio test 1 breakpoint1.31.34.02.0-1.31.41.21.21.1-1.01.0-1.61.31.0-0.90.50.50.60.4
Progressive ratio test 1 inactive lever presses3.74.012.33.5-2.22.12.22.32.1-2.01.9-2.62.11.8-1.61.01.11.10.2
Progressive ratio test 2 active lever presses0.10.11.01.0-0.40.30.30.30.2-0.20.1-0.10.10.10.0-0.3-0.2-0.2-0.1
Progressive ratio test 2 breakpoint0.10.11.11.1-0.50.40.40.40.3-0.30.2-0.20.20.2-0.0-0.2-0.1-0.2-0.1
Progressive ratio test 2 inactive lever presses2.22.68.73.0-2.01.71.81.91.7-1.71.6-1.71.51.4-1.20.70.90.8-0.4
Incentive Sensitization - Responses0.10.10.60.3-0.0-0.2-0.1-0.1-0.20.1-0.20.8-0.5-0.30.3-0.5-0.3-0.5-0.7
Incentive Sensitization - Breakpoint0.30.31.10.20.1-0.4-0.3-0.3-0.30.3-0.41.0-0.7-0.50.6-0.7-0.6-0.7-0.6
Sum of active levers in priming session hrs 5-61.01.01.50.6-1.11.01.00.91.0-1.10.9-0.50.71.0-1.11.01.21.2-1.2
Progressive ratio0.20.31.61.1-0.10.20.10.30.1-0.10.1-0.70.3-0.00.2-0.6-0.2-0.31.3
Food seeking constrained by brief footshock3.74.58.02.8-2.22.32.22.32.1-2.22.2-2.82.42.0-1.91.81.81.7-0.2
Seeking ratio, punishment vs. effort0.60.81.90.1-0.80.80.80.70.8-0.80.8-0.50.80.9-1.01.41.01.1-1.2
Retroperitoneal fat weight20.968.773.2-7.68.3-8.4-8.4-8.4-8.58.5-8.67.9-8.3-8.58.5-8.4-8.5-8.57.1
Reaction time number correct0.60.81.00.7-0.90.90.90.90.9-0.90.9-1.00.90.9-0.90.91.01.0-0.8
Reaction time mean minus median0.00.10.80.00.20.1-0.1-0.1-0.10.1-0.1-0.30.1-0.10.1-0.1-0.2-0.20.9
Reaction time mean minus median AUC0.10.10.6-0.20.3-0.1-0.3-0.3-0.30.2-0.30.0-0.2-0.30.3-0.2-0.3-0.30.8
Reaction time num false alarms0.20.21.4-0.4-0.40.30.20.10.3-0.20.10.20.10.3-0.50.70.70.7-1.2
Reaction time num false alarms AUC0.30.42.1-0.4-0.60.50.40.20.4-0.30.30.10.20.4-0.60.90.80.8-1.5
Reaction time trials correct on left0.60.81.00.7-0.90.90.90.90.9-0.90.9-1.00.90.9-0.90.91.01.0-0.8
Reaction time trials on left0.60.91.10.8-1.00.90.90.91.0-0.90.9-1.01.00.9-1.00.91.01.0-0.8
Reaction time mean1.21.61.9-1.31.3-1.2-1.2-1.3-1.31.3-1.21.1-1.3-1.31.3-1.4-1.2-1.21.4
Reaction time mean AUC1.01.31.9-1.21.1-1.1-1.1-1.2-1.21.2-1.11.0-1.2-1.21.2-1.2-1.1-1.11.4
Median of all reaction times1.21.61.9-1.41.3-1.3-1.3-1.3-1.31.3-1.21.3-1.4-1.31.3-1.4-1.2-1.21.1
Reaction time omissions0.10.10.10.3-0.40.40.30.30.3-0.30.3-0.40.30.3-0.30.30.30.3-0.0
Reaction time false alarm rate0.10.10.7-0.8-0.1-0.0-0.2-0.4-0.20.2-0.30.6-0.3-0.1-0.10.30.20.2-0.8
Reaction time premature initiation rate0.20.20.6-0.60.4-0.5-0.4-0.6-0.50.5-0.50.8-0.6-0.50.5-0.3-0.5-0.5-0.1
Reaction time premature initiations0.00.00.3-0.1-0.10.00.1-0.00.0-0.00.00.2-0.00.0-0.10.20.10.1-0.6
Std. dev. reaction times0.40.51.4-0.50.7-0.5-0.7-0.7-0.70.7-0.70.3-0.5-0.70.8-0.7-0.8-0.81.2
Reaction time trials completed0.60.91.10.8-1.00.90.90.91.0-0.90.9-1.01.00.9-1.00.91.01.0-0.8
Reaction time trials AUC0.81.11.30.9-1.11.01.01.11.1-1.11.0-1.11.11.1-1.11.11.11.1-0.9
Run reversals in cocaine runway, females0.10.10.8-0.90.2-0.2-0.3-0.5-0.30.3-0.40.4-0.3-0.20.10.20.00.10.0
Run reversals in cocaine runway, males0.20.20.6-0.3-0.30.30.20.10.3-0.20.3-0.40.40.4-0.50.70.70.8-0.1
Latency to leave start box in cocaine runway0.50.50.80.8-0.50.70.70.90.8-0.80.9-0.60.70.8-0.70.60.60.7-0.7
Latency to leave start box in cocaine runway, F0.60.71.40.7-0.80.90.90.80.8-0.80.9-0.40.60.8-0.80.80.80.9-1.2
Latency to leave start box in cocaine runway, M0.50.41.21.1-0.40.50.60.90.7-0.60.7-1.10.80.7-0.50.30.30.30.2
Std. dev. time between licks in bursts0.10.10.6-0.00.2-0.3-0.2-0.1-0.20.2-0.20.5-0.3-0.20.3-0.2-0.4-0.4-0.8
Total sessions with >9 infusions2.02.25.22.3-1.51.71.41.61.5-1.31.3-2.11.81.4-1.20.91.01.10.4
Short access day 1 total inactive lever presses5.15.710.03.2-2.92.62.72.62.5-2.52.3-2.02.12.3-2.31.91.92.0-1.8
Short access day 10 total inactive lever presses1.11.22.51.6-1.41.21.31.21.2-1.11.1-0.91.01.1-1.10.80.91.0-0.7
Short access day 1 total infusions4.54.810.23.2-2.42.52.32.42.2-2.12.2-2.82.42.1-1.91.51.61.6-0.1
Short access day 10 total infusions3.74.16.02.5-2.32.32.12.12.1-2.12.0-2.22.12.0-2.01.81.81.8-1.0
Short access total infusions2.63.06.32.5-1.91.91.81.91.8-1.71.6-2.21.91.7-1.51.21.31.3-0.1
Short access day 1 locomotion6.06.411.03.3-2.62.82.62.72.6-2.52.5-3.22.92.5-2.32.02.02.1-0.6
Short access day 10 total locomotion0.80.91.61.3-1.31.01.01.01.0-1.01.0-0.90.90.9-0.90.70.40.5-0.5
Short access total locomotion0.60.61.81.3-1.00.90.80.90.8-0.70.7-1.00.80.7-0.60.40.20.30.1
One hour access (0.3 mA shock)1.82.13.51.9-1.61.51.61.61.5-1.61.5-1.51.41.4-1.41.21.31.2-0.9
Compulsive drug intake0.40.42.2-1.50.7-0.6-0.7-0.8-0.60.5-0.60.6-0.6-0.50.3-0.10.0-0.00.3
One hour access (shock baseline)1.61.84.12.0-1.41.51.51.51.4-1.41.4-1.41.51.3-1.21.00.90.9-0.9
Social response proportion0.40.41.0-0.10.7-0.5-0.6-0.5-0.60.6-0.60.1-0.4-0.60.7-0.8-0.8-0.81.0
Social responses0.10.10.40.40.2-0.1-0.2-0.1-0.20.2-0.3-0.1-0.1-0.30.4-0.6-0.6-0.60.4
Social time0.60.82.10.60.6-0.5-0.6-0.4-0.70.6-0.70.1-0.5-0.81.1-1.5-1.4-1.41.4
Soleus weight4.312.615.02.7-3.53.53.53.43.6-3.53.6-3.93.83.7-3.83.93.93.9-2.4
Bone: stiffness0.00.00.10.10.1-0.2-0.1-0.0-0.10.1-0.1-0.0-0.0-0.10.2-0.1-0.3-0.30.0
Tibialis anterior weight3.512.113.33.1-3.43.53.53.53.5-3.53.6-3.13.43.6-3.63.63.63.6-3.4
Time to tail flick, vehicle, before self-admin2.52.63.0-1.51.7-1.5-1.6-1.7-1.71.7-1.71.3-1.4-1.71.7-1.5-1.7-1.71.7
Time to tail flick, vehicle, after self-admin4.44.75.7-2.02.2-2.1-2.3-2.3-2.32.4-2.31.6-1.8-2.22.2-2.1-2.3-2.32.3
Time to tail flick, test, before self-admin0.50.50.80.7-0.90.70.80.70.7-0.70.7-0.70.70.7-0.70.70.60.6-0.4
Time to tail flick, test, after self-admin0.10.10.6-0.10.0-0.1-0.2-0.3-0.30.4-0.3-0.1-0.1-0.30.3-0.3-0.4-0.40.8
Delta time to tail flick, vehicle, before/after SA0.00.00.10.10.1-0.2-0.2-0.1-0.10.2-0.1-0.10.0-0.10.2-0.2-0.3-0.30.3
Delta time to tail flick, test, before/after SA0.40.40.50.7-0.70.70.60.60.6-0.60.6-0.70.60.6-0.60.60.50.5-0.3
Tibia length2.36.67.9-2.02.5-2.6-2.6-2.4-2.62.6-2.62.5-2.6-2.62.7-2.8-2.8-2.82.1
Ambulatory time before self-admin0.30.32.4-0.1-0.30.10.20.30.4-0.30.20.30.10.4-0.40.60.50.5-1.6
Ambulatory time after self-admin0.50.61.4-0.80.8-1.0-0.8-0.6-0.70.8-0.71.2-1.0-0.70.7-0.7-0.5-0.5-0.3
Bone: tissue strength0.90.81.9-1.41.0-1.0-1.0-1.0-1.01.0-0.90.8-0.9-0.90.8-0.6-0.7-0.70.7
Total heroin consumption2.93.43.91.5-1.81.91.91.81.8-1.81.9-1.81.91.9-1.91.92.02.0-1.4
Bone: trabecular number4.26.67.82.5-2.72.62.62.62.6-2.62.6-2.82.72.6-2.62.52.62.6-1.7
Bone: trabecular spacing3.54.57.6-2.52.2-2.3-2.2-2.3-2.22.2-2.12.8-2.4-2.12.0-1.8-1.8-1.80.8
Bone: trabecular thickness0.81.01.81.3-1.01.01.01.11.0-1.01.0-1.31.11.0-0.90.80.80.8-0.6
Bone: trabecular tissue density0.20.20.60.7-0.50.40.50.60.5-0.50.5-0.40.50.5-0.40.40.30.3-0.5
Water consumed over 24 hours1.82.12.91.4-1.51.41.51.51.5-1.41.4-1.41.41.5-1.51.31.51.5-1.7
Number of responses in last shaping day0.50.51.91.4-0.50.60.60.80.6-0.50.6-1.20.80.5-0.40.10.20.30.8