Hub : Genes

Grk5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Grk5 0.12 0.08 5.2e-04 0.07 0.05 0.06 0.06 7.4e-04 4.6e-03 2.5e-03 1.7e-03
2 pVTA mRNA stability Grk5 0.06 0.04 1.9e-05 0.02 0.05 0.03 0.04 6.1e-03 6.5e-05 2.1e-03 4.9e-04
3 Liver mRNA stability Grk5 0.03 0.02 9.8e-03 0 0.01 0 0.01 2.2e-01 3.6e-02 2.1e-01 5.6e-02
4 OFC alternative TSS XM_039088827.2 0.1 0.07 9.6e-03 0.12 0.05 0.05 0.05 7.1e-04 2.9e-02 2.5e-02 2.9e-02
5 Brain mRNA stability Grk5 0.03 0.02 1.9e-03 0.01 0.02 0.01 0.02 2.0e-02 2.3e-03 3.0e-02 5.1e-03
6 Adipose gene expression Grk5 0.19 0.08 0.0e+00 0.24 0.24 0.24 0.24 4.4e-26 3.9e-26 4.2e-26 4.4e-26
7 PL gene expression Grk5 0.02 0.02 8.4e-03 0.01 0.01 0.01 0 5.4e-02 3.0e-02 1.3e-02 8.5e-02
8 NAcc mRNA stability Grk5 0.04 0.02 3.9e-07 0.05 0.04 0.04 0.04 9.3e-08 5.0e-07 1.9e-06 4.8e-07
9 OFC isoform ratio XM_039088810.2 0.21 0.13 3.2e-03 0.14 0.11 0.07 0.09 2.9e-04 1.6e-03 7.6e-03 4.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density1.93.47.9-2.8-2.0-2.4-2.1-1.71.5-1.10.7-1.4
Area under the delay curve0.30.52.20.3-0.5-0.5-1.0-0.30.5-1.50.4-0.5
BMI with tail25.689.4131.6-11.5-11.2-10.2-10.6-10.39.9-7.37.6-4.0
BMI without tail10.857.489.7-9.5-8.9-8.0-8.4-8.37.8-5.86.2-3.1
Body weight22.096.4148.1-12.2-11.4-11.0-11.1-10.39.7-7.97.4-5.3
Weight adjusted by age2.26.410.8-3.3-3.0-2.4-2.6-3.02.7-1.82.3-0.1
Bone surface1.63.26.7-2.6-2.0-2.3-2.2-1.71.5-1.10.8-1.0
Bone volume3.46.811.9-3.5-3.1-2.9-3.0-2.82.6-1.81.8-1.3
Breakpoint value in progressive ratio session2.23.97.3-1.5-1.9-2.2-2.5-1.61.5-2.71.4-2.1
Number of licking bursts0.20.52.2-0.10.1-0.8-0.20.4-0.5-0.8-0.6-1.5
Context. condit. distance diff. score0.10.10.40.10.2-0.10.10.3-0.30.4-0.70.1
Locomotion velocity, session 11.41.62.31.01.51.11.31.4-1.51.2-1.20.9
Locomotion distance, session 12.12.64.12.01.62.01.41.4-1.21.8-1.01.7
Locomotion velocity, session 21.11.42.51.01.11.61.40.8-0.81.4-0.31.5
Locomotion distance, session 20.50.71.2-0.6-0.90.1-0.7-1.01.10.51.01.1
Locomotion velocity, session 32.12.44.92.21.81.71.21.7-1.51.3-1.40.7
Locomotion distance, session 31.11.31.91.41.21.31.11.1-1.01.3-0.80.9
Stereotopy head waving bouts, day 30.40.51.20.90.51.00.70.3-0.20.7-0.21.1
Stereotopy head waving duration, day 30.20.31.21.10.40.80.60.3-0.20.0-0.00.5
Locomotion velocity, session 70.10.10.30.40.20.00.00.3-0.20.2-0.5-0.1
Locomotion distance, session 70.20.30.5-0.7-0.7-0.3-0.3-0.70.70.50.30.3
Stereotopy head waving bouts, day 70.40.51.61.00.3-0.3-0.60.5-0.3-1.3-0.4-0.6
Stereotopy head waving duration, day 71.01.22.21.50.8-0.4-0.31.2-0.9-1.4-1.2-1.3
Locomotion velocity, session 81.92.34.31.01.81.11.41.8-1.91.5-2.10.2
Locomotion distance, session 80.71.03.10.40.80.80.80.8-0.81.7-1.11.1
Degree of sensitization distance1.81.94.6-2.1-1.7-1.5-1.2-1.61.4-0.80.8-0.6
Degree of sensitization stereotypy0.80.93.20.5-0.1-1.0-0.90.3-0.1-1.8-0.4-1.5
Conditioned locomotion0.10.10.20.40.30.10.20.3-0.3-0.40.1-0.5
Cocaine response after cond. corrected2.94.310.91.31.43.02.40.7-0.73.3-0.22.9
Cocaine response after cond. not corrected3.55.110.81.52.13.02.91.4-1.53.3-0.92.4
Cocaine response before conditioning1.01.12.4-0.01.0-0.60.61.2-1.4-0.5-1.6-1.5
Saline control response0.40.51.40.80.61.21.10.2-0.20.50.50.6
Bone: connectivity density0.10.20.5-0.7-0.3-0.7-0.6-0.10.00.1-0.5-0.4
Bone: cortical apparent density6.39.915.63.53.43.93.92.9-2.83.2-1.92.0
Bone: cortical area10.116.525.5-5.1-4.6-4.5-4.3-4.24.0-3.63.1-2.4
Bone: cortical porosity0.50.51.1-0.9-0.7-0.9-1.0-0.50.5-0.50.0-0.8
Bone: cortical porosity1.82.03.4-1.7-1.5-1.8-1.9-1.11.1-1.40.4-1.4
Bone: cortical thickness6.610.916.4-4.0-3.9-3.2-3.3-3.83.6-2.63.0-1.5
Bone: cortical thickness6.57.912.6-2.5-3.5-2.0-3.1-3.53.6-2.13.3-0.6
Bone: cortical tissue density7.011.116.93.73.64.14.13.2-3.03.3-2.22.0
Condit. Reinf. active minus inactive responses1.41.63.40.31.30.81.21.3-1.41.7-1.80.6
Condit. Reinf. active-inactive response ratio1.82.03.60.71.60.91.51.6-1.71.5-1.90.8
Condit. Reinf. active responses0.30.31.5-1.2-0.3-0.5-0.2-0.10.10.8-0.7-0.1
Condit. Reinf. inactive responses1.82.35.2-2.3-1.8-1.7-1.6-1.61.5-0.60.8-1.2
Incentive salience index mean0.81.03.10.00.80.70.90.8-0.91.8-1.30.8
Condit. Reinf. lever presses0.30.52.40.10.40.70.60.4-0.31.5-0.60.8
Condit. Reinf. active minus inactive responses1.32.04.1-1.8-1.2-2.0-1.9-0.80.6-1.60.2-1.4
Condit. Reinf. active-inactive response ratio1.52.44.8-1.7-1.5-2.1-2.2-1.11.0-1.80.8-1.2
Condit. Reinf. active responses1.92.75.9-1.9-1.4-2.4-2.0-0.90.8-1.80.2-1.9
Condit. Reinf. inactive responses0.60.92.3-1.3-0.8-1.5-0.8-0.50.4-1.0-0.2-1.2
Condit. Reinf. lever presses1.52.13.2-1.8-1.6-1.8-1.6-1.31.2-1.30.8-1.5
Condit. Reinf. lever reinforcers received1.11.53.6-1.6-0.9-1.9-1.4-0.50.4-1.3-0.1-1.7
Conditioned reinforcement - actives0.52.13.61.21.61.71.91.3-1.41.4-0.71.6
Conditioned reinforcement - inactives0.30.91.41.11.10.80.91.2-1.10.4-1.0-0.6
Conditioned locomotion2.33.45.51.82.02.22.31.6-1.71.9-0.81.9
Patch foraging indifference point 0 sec2.87.911.1-2.9-3.3-2.7-3.3-3.13.1-2.52.5-1.5
Patch foraging indifference point AUC0.10.21.10.3-0.2-0.0-0.4-0.20.3-0.60.6-1.1
Delay disc. indifference point, 0s delay0.50.61.3-0.7-0.9-0.4-1.1-0.91.0-0.40.40.5
Delay disc. indifference point, 16s delay0.20.31.90.3-0.1-0.6-0.50.10.0-1.4-0.1-0.4
Delay disc. indifference point, 2s delay0.20.30.80.9-0.10.5-0.4-0.20.4-0.20.40.9
Delay disc. indifference point, 24s delay0.40.72.20.2-0.6-0.6-1.0-0.50.7-1.50.7-0.9
Delay disc. indifference point, 4s delay0.30.31.10.2-0.4-0.4-0.9-0.20.4-1.10.2-0.4
Delay disc. indifference point, 8s delay0.10.20.90.6-0.00.1-0.40.00.2-0.90.2-0.4
Indifference point function ln k0.20.51.5-1.2-0.8-0.3-0.1-0.90.70.30.50.7
Indifference point function log k0.20.51.5-1.2-0.8-0.3-0.1-0.90.70.30.50.7
Patch foraging total patch changes 0 sec3.39.813.8-3.3-3.7-3.0-3.6-3.53.5-2.72.8-1.6
Patch foraging total patch changes 12 sec3.44.66.9-2.0-2.5-2.1-2.6-2.22.2-2.01.9-1.6
Patch foraging total patch changes 18 sec1.33.14.2-1.8-2.0-1.7-2.1-1.81.7-1.61.6-1.6
Patch foraging total patch changes 24 sec0.31.03.1-0.2-0.9-0.6-1.1-0.80.9-1.30.8-1.8
Patch foraging total patch changes 6 sec3.66.17.5-2.2-2.7-2.2-2.7-2.62.6-2.62.3-2.3
Patch foraging time to switch 0 sec0.51.92.81.51.71.31.41.6-1.61.2-1.30.7
Patch foraging water rate 0 sec1.14.36.3-2.2-2.5-1.9-2.2-2.42.4-1.62.1-0.7
Patch foraging water rate 12 sec1.04.15.2-2.1-2.3-2.3-2.3-2.12.0-2.01.8-1.2
Patch foraging water rate 18 sec0.92.14.0-1.3-1.7-0.6-1.2-1.91.9-0.42.00.8
Patch foraging water rate 24 sec3.95.59.8-2.3-2.9-1.4-2.0-3.13.1-1.13.00.6
Patch foraging water rate 6 sec2.23.25.3-2.2-2.2-1.2-1.5-2.32.2-0.82.10.0
Seeking ratio, delayed vs. immediate footshock6.18.711.63.23.43.13.43.1-3.03.0-2.41.3
Distance traveled before self-admin1.22.77.01.91.12.41.60.6-0.41.80.32.6
Distance traveled after self-admin1.72.96.12.41.62.51.71.3-1.01.7-0.71.6
Extensor digitorum longus weight1.56.011.1-3.3-2.8-2.6-2.1-2.72.5-1.92.3-1.1
Bone: elastic displacement0.20.31.10.0-0.40.2-0.3-0.60.6-0.41.10.3
Bone: elastic work2.53.37.0-1.1-2.1-0.6-1.7-2.42.5-1.02.60.8
Bone: endosteal estimation1.43.35.8-2.4-2.1-2.2-2.2-1.81.7-1.41.2-0.7
Bone: endosteal perimeter2.35.87.7-2.7-2.7-2.8-2.8-2.42.3-2.51.8-1.1
Epididymis fat weight16.885.1123.4-11.1-10.4-11.0-10.4-9.08.5-8.36.1-6.8
Delta time in closed arm before/after self-admin0.50.41.5-0.1-0.10.60.4-0.40.31.00.71.2
Delta time in open arm before/after self-admin1.82.26.5-1.4-0.4-2.1-1.10.2-0.4-2.0-1.0-2.5
Diff in mean of infusions in LGA sessions0.61.13.2-0.3-0.9-1.0-1.5-0.80.9-1.80.6-1.0
Delay discount exponential model param0.40.52.3-0.40.50.41.00.4-0.61.5-0.50.5
Extinction: sum of active levers before priming0.50.81.9-0.4-0.7-1.1-1.3-0.40.5-1.00.1-1.4
Active lever presses in extinction session 63.03.05.0-1.2-2.0-1.3-2.2-1.92.0-1.71.9-0.8
Bone: final force7.512.318.6-4.3-4.2-3.4-3.7-4.03.9-2.63.0-1.0
Bone: final moment7.912.820.4-4.5-4.3-3.6-3.8-4.13.9-2.63.0-1.2
Food consumed during 24 hour testing period0.20.51.2-1.1-0.8-0.5-0.8-0.80.7-0.20.80.1
Glucose6.510.215.9-3.2-3.3-4.0-3.8-2.82.6-4.01.9-2.6
Heart weight12.119.531.5-5.6-4.9-5.2-5.1-4.44.1-3.83.1-2.4
Delay discount hyperbolic model param0.40.52.3-0.40.50.41.00.4-0.61.5-0.50.4
Intermittent access intake day 1-15 change0.00.20.60.70.50.80.30.2-0.20.30.10.7
Intermittent access intake escalation0.00.10.20.40.40.50.20.2-0.20.10.00.5
Intermittent access intake escalation 20.10.10.3-0.3-0.2-0.1-0.3-0.40.2-0.30.50.5
Intermitt. access day 1 inactive lever presses0.11.54.3-1.2-1.0-1.6-1.3-0.60.6-1.50.3-2.1
Intermitt. access day 15 inactive lever presses0.31.42.3-1.0-1.2-1.0-1.5-1.21.2-1.51.1-0.8
Intermitt. access escalation Index0.10.30.80.10.60.20.60.6-0.70.5-0.90.0
Intermittent access day 1 total infusions0.10.30.70.70.60.80.70.5-0.40.5-0.10.3
Intermittent access day 15 total infusions0.20.40.90.90.71.00.70.4-0.40.40.10.5
Intermittent access terminal intake (last 3 days)0.10.20.60.70.40.60.50.2-0.2-0.00.30.2
Intermittent access total infusions0.50.61.21.00.81.01.10.7-0.60.7-0.10.3
Intermittent access day 1 locomotion0.71.32.61.61.01.61.50.7-0.61.1-0.01.1
Intermittent access day 15 total locomotion0.10.21.21.10.30.30.20.4-0.2-0.4-0.1-0.7
Intermittent access total locomotion1.01.22.41.40.91.61.50.6-0.51.2-0.01.1
Intermittent access standard deviation0.00.21.00.5-0.2-0.2-0.5-0.20.2-1.00.5-0.5
Left kidney weight5.242.065.6-8.1-7.7-6.2-6.9-7.57.0-4.06.6-1.5
Right kidney weight7.250.380.4-9.0-8.5-6.4-7.1-8.57.9-4.07.4-1.3
Cocaine induced anxiety1.02.74.71.71.82.22.01.3-1.41.5-0.31.8
Post-drug Anxiety0.10.10.2-0.10.3-0.10.40.3-0.40.1-0.30.1
Baseline Anxiety1.62.76.5-1.6-1.4-2.6-1.9-0.80.8-1.7-0.4-2.2
Tail length0.21.32.5-1.6-0.8-1.4-1.1-0.60.4-1.40.4-1.5
Length with tail1.98.214.3-3.8-3.0-3.6-3.2-2.62.3-2.71.6-2.4
Length without tail2.312.220.5-4.3-3.7-4.5-4.0-3.12.8-3.41.8-3.1
Times rat made contact with spout1.31.52.8-1.7-1.4-1.3-1.3-1.31.2-0.71.1-0.3
Lifetime Intake0.50.71.31.00.91.11.10.7-0.70.8-0.00.4
Liver weight, left10.317.827.6-5.3-5.0-4.5-4.5-4.64.4-3.33.4-2.1
Liver weight, right4.37.615.4-3.9-3.5-2.7-2.8-3.33.1-1.02.0-0.7
Locomotor activity0.10.20.60.10.50.20.60.5-0.60.1-0.8-0.0
Locomotor testing distance0.40.91.70.70.91.31.20.7-0.71.1-0.61.0
Locomotor testing rearing0.00.20.50.3-0.00.50.4-0.30.3-0.20.50.7
Locomotion in novel chamber0.60.92.1-0.4-0.90.4-0.5-1.21.30.41.41.0
Locomotion in novel chamber post-restriction0.30.92.70.6-0.50.9-0.2-0.81.10.51.21.6
Fecal boli incidents, locomotor time 10.10.20.8-0.3-0.2-0.9-0.5-0.00.0-0.90.2-0.2
Change in fecal boli incidents, locomotor task0.50.51.4-1.2-0.9-0.5-0.7-0.90.80.10.6-0.3
Time >=10cm from walls, locomotor time 10.10.10.30.10.40.10.30.4-0.50.4-0.5-0.1
Bouts of movement, locomotor time 10.30.51.5-0.7-0.3-0.8-0.4-0.20.1-1.1-0.0-1.2
Total resting periods, locomotor time 10.30.30.7-0.8-0.4-0.6-0.3-0.40.2-0.80.2-0.8
Rest time, locomotor task time 10.71.22.4-1.4-1.1-0.1-0.4-1.41.20.11.51.1
Distance moved, locomotor task time 10.10.31.31.10.40.3-0.20.5-0.30.1-0.6-0.4
Vertical activity count, locomotor time 10.10.51.81.30.60.70.20.7-0.50.5-0.80.1
Time >=10cm from walls, locomotor time 20.10.30.6-0.6-0.7-0.3-0.6-0.70.80.20.40.0
Bouts of movement, locomotor time 20.00.10.30.20.40.40.50.2-0.30.10.10.3
Total resting periods, locomotor time 20.00.10.30.30.50.50.60.3-0.40.10.10.3
Rest time, locomotor task time 20.10.10.2-0.00.40.40.50.2-0.30.3-0.40.4
Distance moved, locomotor task time 20.10.10.20.4-0.20.2-0.4-0.20.40.20.40.1
Vertical activity count, locomotor time 20.00.10.30.50.10.3-0.10.10.00.4-0.10.0
Light reinforcement 10.10.51.20.2-0.11.00.5-0.40.41.10.71.0
Light reinforcement 20.20.50.70.50.80.60.80.7-0.80.7-0.40.6
Bone: marrow area1.53.76.5-2.6-2.2-2.3-2.3-2.01.8-1.51.4-0.7
Bone: maximum diameter5.010.116.1-3.7-3.3-4.0-3.6-2.72.6-3.51.8-2.8
Bone: maximum force4.99.716.9-4.1-3.8-3.1-3.3-3.63.4-2.02.6-0.7
Bone: maximum moment5.29.817.9-4.2-3.7-3.2-3.3-3.53.3-2.12.5-0.9
Mean time between licks in bursts0.21.12.9-0.10.9-0.30.71.2-1.40.1-1.7-1.3
Mean num. licks in bursts0.41.22.6-0.9-1.00.2-0.6-1.41.30.51.41.6
Cd content in liver0.80.93.1-0.0-0.11.10.9-0.60.51.01.31.8
Co content in liver0.91.12.6-0.5-1.00.4-0.4-1.31.30.51.61.4
Cu content in liver0.10.21.0-0.1-0.3-0.00.1-0.40.4-0.11.00.0
Fe content in liver0.91.14.0-1.2-0.5-1.6-0.7-0.0-0.1-0.8-0.7-2.0
K content in liver0.10.10.40.1-0.1-0.10.1-0.20.1-0.40.6-0.2
Mg content in liver0.50.52.40.0-0.50.30.2-0.80.8-0.41.60.6
Mn content in liver0.60.71.7-0.6-0.9-0.2-0.6-1.11.1-0.31.30.4
Na content in liver1.51.72.9-0.9-1.4-1.2-1.5-1.31.3-1.51.7-0.5
Rb content in liver0.00.10.20.0-0.1-0.30.0-0.10.1-0.50.3-0.2
Se content in liver0.10.10.60.30.40.40.70.3-0.30.30.10.1
Sr content in liver3.22.86.71.81.42.61.90.9-0.71.60.12.4
Zn content in liver0.91.13.20.80.41.41.2-0.20.10.91.21.8
Bone: minimum diameter5.29.915.6-3.9-3.5-3.8-3.6-3.12.9-3.02.1-1.8
Time in familiar zone, hab. session 11.61.73.1-1.1-1.5-1.4-1.8-1.41.4-1.41.0-0.2
Time in novel zone, hab. session 13.53.96.31.72.41.42.12.5-2.51.5-2.3-0.3
Total zone transitions, hab. session 10.10.20.40.4-0.30.4-0.1-0.40.60.20.60.5
Total locomotion distance, hab. session 10.20.30.60.30.50.00.30.6-0.60.2-0.8-0.7
Locomotion velocity, hab. session 10.10.10.30.00.2-0.00.20.3-0.30.2-0.6-0.5
Time in familiar zone, hab. session 21.21.34.80.10.9-0.7-0.21.3-1.3-0.2-2.2-1.5
Time in novel zone, hab. session 20.50.61.9-0.3-0.60.2-0.1-0.90.90.21.41.2
Total zone transitions, hab. session 20.20.20.5-0.0-0.50.1-0.3-0.60.70.10.70.3
Total locomotion distance, hab. session 20.40.50.9-0.9-0.8-0.9-0.9-0.60.6-0.40.3-0.5
Locomotion velocity, hab. session 20.50.71.1-0.9-1.0-0.9-1.0-0.90.9-0.50.6-0.5
Novel to familiar place preference ratio0.30.41.8-0.40.4-0.40.10.7-0.80.2-1.4-0.6
Novelty place preference0.30.41.9-0.20.6-0.30.20.8-0.90.2-1.4-0.4
Time in novel zone, NPP test0.60.83.3-0.50.6-0.8-0.00.9-1.0-0.0-1.8-0.9
Total zone transitions, NPP test0.50.71.3-0.9-1.0-0.1-0.5-1.11.10.31.10.4
Total locomotion distance, NPP test0.20.20.4-0.5-0.6-0.1-0.3-0.60.60.40.50.2
Locomotion velocity, NPP test0.40.51.3-0.3-0.70.5-0.0-0.90.90.71.10.7
Intraocular pressure0.40.62.70.10.1-0.9-0.40.5-0.4-0.6-1.1-1.7
Delta distance traveled before/after self-admin0.30.30.50.70.60.50.40.6-0.50.2-0.7-0.4
Delta ambulatory time before/after self-admin0.10.20.60.60.40.40.30.5-0.40.1-0.6-0.8
Parametrial fat weight28.667.3100.1-10.0-9.4-9.2-9.0-8.57.9-7.16.0-5.6
Pavlov. Cond. lever latency0.50.71.11.01.00.60.91.0-1.0-0.0-0.7-0.4
Pavlov. Cond. magazine entry latency0.60.71.6-1.3-1.0-1.1-1.1-0.80.7-0.30.3-0.5
Pavlov. Cond. change in total contacts2.02.14.6-2.1-1.5-2.1-1.9-1.11.0-1.00.2-0.9
Pavlov. Cond. index score0.91.22.3-1.5-1.3-1.3-1.3-1.11.1-0.60.7-0.4
Pavlov. Cond. latency score0.81.01.8-1.4-1.2-1.1-1.2-1.01.0-0.40.6-0.3
Pavlov. Cond. lever contacts1.01.11.9-1.2-1.3-1.2-1.4-1.21.2-0.70.7-0.2
Pavlov. Cond. magazine entry number0.81.02.31.51.21.31.11.0-0.90.6-0.50.5
Pavlov. Cond. intertrial magazine entries1.72.03.9-2.0-1.8-1.2-1.4-1.71.6-0.41.3-0.2
Pavlov. Cond. lever-magazine prob. diff.1.01.32.7-1.6-1.3-1.5-1.4-1.11.0-0.60.6-0.6
Pavlov. Cond. response bias0.60.81.5-1.2-1.1-1.0-1.0-1.01.0-0.30.5-0.0
Pavlov. Cond. lever latency0.91.23.41.40.91.61.00.5-0.41.0-0.01.9
Pavlov. Cond. magazine entry latency0.50.72.40.40.4-0.5-0.40.9-0.7-0.4-1.5-1.3
Pavlov. Cond. change in total contacts0.20.52.2-0.7-0.3-1.0-0.4-0.1-0.0-0.8-0.2-1.5
Pavlov. Cond. index score0.40.62.7-0.6-0.3-1.1-0.60.1-0.1-0.7-0.7-1.6
Pavlov. Cond. latency score0.30.52.5-0.7-0.4-1.0-0.5-0.00.0-0.6-0.5-1.6
Pavlov. Cond. lever contacts0.60.92.1-1.2-0.9-1.3-0.9-0.60.5-0.80.2-1.5
Pavlov. Cond. magazine entry number0.20.30.9-0.3-0.10.40.3-0.40.30.30.91.0
Pavlov. Cond. intertrial magazine entries1.94.27.6-2.4-2.4-1.2-1.7-2.72.5-1.12.80.1
Pavlov. Cond. lever-magazine prob. diff.0.30.42.0-0.3-0.2-0.8-0.50.2-0.1-0.5-0.7-1.4
Pavlov. Cond. response bias0.71.03.5-1.0-0.4-1.5-0.80.1-0.1-0.9-0.8-1.9
Time in closed arm before self-admin0.10.10.30.60.30.30.10.3-0.30.3-0.40.3
Time in closed arm after self-admin0.91.03.00.80.51.30.90.1-0.11.40.81.7
Time in open arm before self-admin0.91.11.91.41.31.21.31.2-1.10.6-0.60.3
Time in open arm after self-admin1.11.33.6-0.30.4-1.3-0.50.8-0.9-1.5-1.4-1.9
Bone: periosteal estimation6.014.223.4-4.8-4.4-4.2-4.2-4.03.7-3.12.9-1.7
Bone: periosteal perimeter8.216.321.4-4.6-4.6-4.5-4.5-4.14.0-4.03.1-2.2
Bone: post-yield work0.40.72.7-1.6-0.8-1.3-0.7-0.60.4-0.3-0.1-0.6
Progressive ratio test 1 active lever presses0.51.01.91.41.01.41.20.8-0.70.7-0.20.8
Progressive ratio test 1 breakpoint0.40.71.61.20.91.21.00.7-0.60.6-0.10.8
Progressive ratio test 1 inactive lever presses0.10.20.50.60.50.30.30.6-0.5-0.1-0.5-0.7
Progressive ratio test 2 active lever presses0.10.10.30.3-0.00.50.2-0.20.20.10.50.2
Progressive ratio test 2 breakpoint0.10.10.20.3-0.00.50.2-0.10.20.10.50.2
Progressive ratio test 2 inactive lever presses0.00.10.3-0.10.20.30.50.2-0.20.2-0.2-0.5
Incentive Sensitization - Responses0.10.40.6-0.7-0.7-0.5-0.6-0.70.7-0.50.7-0.3
Incentive Sensitization - Breakpoint0.10.30.4-0.6-0.6-0.4-0.4-0.60.5-0.40.5-0.4
Sum of active levers in priming session hrs 5-60.50.51.2-0.7-0.7-0.6-0.9-0.60.5-0.60.4-1.1
Progressive ratio1.02.96.32.51.92.22.01.7-1.51.1-1.00.8
Food seeking constrained by brief footshock4.35.410.33.22.72.22.32.7-2.41.4-2.40.3
Seeking ratio, punishment vs. effort0.00.00.2-0.00.10.00.10.2-0.20.3-0.40.2
Retroperitoneal fat weight27.7124.1185.5-13.6-12.9-12.8-12.5-11.410.8-9.27.6-7.5
Reaction time number correct0.10.51.1-0.8-0.5-1.0-0.7-0.30.3-1.10.3-0.8
Reaction time mean minus median0.00.20.60.8-0.00.50.1-0.10.30.10.50.7
Reaction time mean minus median AUC0.10.71.90.9-0.30.7-0.1-0.60.8-0.21.31.4
Reaction time num false alarms0.40.61.4-1.2-0.8-0.3-0.7-0.80.80.80.20.9
Reaction time num false alarms AUC0.40.81.7-1.3-1.1-0.5-1.0-1.11.10.40.40.8
Reaction time trials correct on left0.10.51.1-0.8-0.5-1.0-0.7-0.30.3-1.10.3-0.8
Reaction time trials on left0.10.51.2-0.8-0.5-1.0-0.7-0.30.3-1.10.2-0.8
Reaction time mean1.02.37.12.71.61.81.31.5-1.20.9-0.70.9
Reaction time mean AUC1.02.57.72.81.72.01.51.5-1.11.0-0.51.1
Median of all reaction times1.93.08.83.01.92.01.61.8-1.51.0-1.00.9
Reaction time omissions0.40.61.30.80.70.10.30.9-0.8-0.3-1.2-1.1
Reaction time false alarm rate0.40.50.8-0.8-0.8-0.2-0.8-0.80.80.80.10.9
Reaction time premature initiation rate0.10.20.50.70.00.60.20.00.20.3-0.10.6
Reaction time premature initiations0.00.10.3-0.0-0.4-0.0-0.3-0.40.6-0.40.30.2
Std. dev. reaction times0.00.10.60.80.10.3-0.10.10.1-0.00.20.5
Reaction time trials completed0.10.51.2-0.8-0.5-1.0-0.7-0.30.3-1.10.2-0.8
Reaction time trials AUC0.20.81.4-1.1-0.7-1.2-0.9-0.60.5-1.20.5-0.8
Run reversals in cocaine runway, females0.50.51.01.00.80.30.70.9-0.8-0.5-0.7-0.5
Run reversals in cocaine runway, males0.70.82.10.90.31.40.6-0.10.11.00.71.4
Latency to leave start box in cocaine runway0.50.61.10.50.8-0.30.41.0-1.0-1.0-0.8-1.0
Latency to leave start box in cocaine runway, F0.20.30.7-0.30.2-0.6-0.10.4-0.5-0.8-0.6-0.9
Latency to leave start box in cocaine runway, M0.20.21.10.60.3-0.20.10.3-0.3-1.0-0.0-0.5
Std. dev. time between licks in bursts1.01.93.50.91.60.81.41.7-1.71.2-1.9-0.1
Total sessions with >9 infusions1.11.43.21.61.11.81.50.9-0.71.20.10.6
Short access day 1 total inactive lever presses0.61.22.20.41.20.71.51.2-1.31.0-1.1-1.1
Short access day 10 total inactive lever presses0.42.75.4-2.3-2.0-1.2-1.6-2.01.9-0.41.7-0.3
Short access day 1 total infusions0.40.81.51.00.91.21.20.7-0.71.1-0.10.3
Short access day 10 total infusions1.21.92.81.61.51.71.51.3-1.21.2-0.71.4
Short access total infusions1.11.63.01.41.31.71.61.1-1.01.4-0.40.9
Short access day 1 locomotion0.20.30.80.90.30.90.50.20.00.50.60.1
Short access day 10 total locomotion0.20.61.41.20.61.11.00.4-0.30.60.21.0
Short access total locomotion1.52.34.82.11.22.21.80.9-0.61.60.31.6
One hour access (0.3 mA shock)0.60.71.50.70.90.40.71.0-1.00.0-0.7-1.2
Compulsive drug intake0.30.52.1-0.8-0.4-0.9-0.6-0.10.1-0.4-0.3-1.4
One hour access (shock baseline)0.41.12.21.31.21.31.51.0-1.00.9-0.50.4
Social response proportion0.10.20.7-0.8-0.5-0.2-0.0-0.40.40.60.10.3
Social responses1.72.33.8-1.7-1.6-1.9-1.6-1.31.3-1.40.9-1.6
Social time0.10.20.4-0.3-0.4-0.6-0.5-0.20.2-0.5-0.2-0.5
Soleus weight3.09.015.0-2.9-3.8-2.1-2.7-3.93.9-2.03.4-0.1
Bone: stiffness2.03.77.7-2.8-2.3-1.9-1.9-2.32.1-1.01.6-0.2
Tibialis anterior weight0.20.61.7-1.3-0.8-0.9-0.2-0.80.6-0.70.6-0.5
Time to tail flick, vehicle, before self-admin0.10.10.2-0.40.0-0.20.10.1-0.2-0.1-0.3-0.5
Time to tail flick, vehicle, after self-admin0.10.10.3-0.3-0.4-0.3-0.5-0.40.4-0.50.4-0.0
Time to tail flick, test, before self-admin1.31.53.41.60.81.81.20.5-0.31.50.31.8
Time to tail flick, test, after self-admin0.50.51.7-0.10.6-0.30.70.8-0.90.1-1.3-0.9
Delta time to tail flick, vehicle, before/after SA1.11.22.6-0.5-1.1-1.1-1.4-1.01.1-1.60.9-0.7
Delta time to tail flick, test, before/after SA0.70.82.2-1.5-0.3-1.4-0.4-0.1-0.2-0.7-0.9-1.3
Tibia length0.30.71.9-0.9-0.9-0.9-1.4-0.80.8-0.60.5-0.3
Ambulatory time before self-admin0.61.84.71.60.82.01.30.3-0.21.50.52.2
Ambulatory time after self-admin1.72.86.12.51.62.51.71.3-1.11.6-0.61.1
Bone: tissue strength0.30.30.60.50.6-0.00.20.7-0.8-0.3-0.7-0.6
Total heroin consumption5.56.512.6-1.9-2.8-2.7-3.5-2.42.5-3.01.7-1.9
Bone: trabecular number1.22.24.0-1.9-1.6-2.0-1.9-1.31.1-1.00.6-1.3
Bone: trabecular spacing2.84.16.42.02.51.72.52.4-2.41.4-1.90.4
Bone: trabecular thickness9.012.517.1-3.9-4.1-3.8-4.1-3.73.5-3.22.6-2.3
Bone: trabecular tissue density1.52.74.11.31.81.82.01.7-1.71.7-1.60.8
Water consumed over 24 hours0.40.82.0-1.0-0.9-0.4-0.5-1.21.0-0.11.40.5
Number of responses in last shaping day0.60.82.11.40.91.40.70.7-0.51.0-0.10.6