chr3:126,323,673-128,707,024

Trait: Retroperitoneal fat weight

Best TWAS P=1.77e-10 · Best GWAS P=4.41e-12 conditioned to 6.61e-04

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose AABR07054000.1 alternative polyA ENSRNOT00000072928 0.26 1836 0.16 2.6e-17 -5.54 2.99e-08 0.41 FALSE
Adipose AABR07054000.1 alternative polyA ENSRNOT00000110455 0.08 22 0.06 5.7e-07 5.21 1.92e-07 0.39 FALSE
Adipose AABR07054000.1 alternative polyA ENSRNOT00000117007 0.07 1 0.04 1.2e-05 5.33 9.91e-08 0.05 FALSE
Adipose AABR07054000.1 gene expression ENSRNOG00000050784 0.42 1 0.3 4.0e-34 5.26 1.40e-07 0.07 FALSE
Adipose AABR07054000.1 isoform ratio ENSRNOT00000072928 0.28 59 0.19 8.1e-21 -5.5 3.70e-08 0.52 FALSE
Adipose AABR07054000.1 isoform ratio ENSRNOT00000110455 0.09 1836 0.06 1.8e-07 5.72 1.04e-08 0.42 FALSE
Adipose AABR07054000.1 isoform ratio ENSRNOT00000117007 0.15 471 0.09 1.3e-10 5.5 3.72e-08 0.56 FALSE
Adipose Esf1 mRNA stability ENSRNOG00000004777 0.17 1671 0.07 2.9e-08 5.2 1.95e-07 0.01 FALSE
Adipose Ndufaf5 mRNA stability ENSRNOG00000004784 0.04 54 0.01 1.5e-02 5.18 2.23e-07 0.45 FALSE
BLA AABR07054000.1 alternative polyA ENSRNOT00000072928 0.14 1836 0.09 1.9e-05 -6.02 1.70e-09 0.47 FALSE
BLA AABR07054000.1 alternative polyA ENSRNOT00000117007 0.12 1 0.08 7.2e-05 5.32 1.03e-07 0.04 FALSE
BLA Flrt3 gene expression ENSRNOG00000004874 0.06 1 0.04 5.4e-03 -5.15 2.58e-07 0.04 FALSE
BLA AABR07054000.1 gene expression ENSRNOG00000050784 0.09 49 0.03 1.5e-02 -6.38 1.77e-10 0.2 TRUE
BLA AABR07054000.1 isoform ratio ENSRNOT00000072928 0.15 1836 0.15 2.4e-08 -5.9 3.62e-09 0.24 FALSE
BLA AABR07054000.1 isoform ratio ENSRNOT00000117007 0.11 1 0.07 1.1e-04 5.32 1.03e-07 0.04 FALSE
BLA AABR07054000.1 intron excision ratio chr3:127725722:127779334 0.06 1 0.03 1.6e-02 5.63 1.83e-08 0.04 FALSE
BLA Tasp1 mRNA stability ENSRNOG00000004493 0.11 5 0.08 2.9e-05 -5.17 2.29e-07 0.53 FALSE
Brain AABR07054000.1 alternative polyA ENSRNOT00000072928 0.03 1 0.02 4.5e-03 -5.32 1.04e-07 0.03 FALSE
Brain AABR07054000.1 gene expression ENSRNOG00000050784 0.04 1 0.05 2.2e-05 -6.08 1.18e-09 0.42 FALSE
Brain Ism1 gene expression ENSRNOG00000063262 0.05 32 0.04 8.7e-05 -5.25 1.50e-07 0.54 FALSE
Brain AABR07054000.1 isoform ratio ENSRNOT00000072928 0.04 1 0.04 6.8e-05 -5.38 7.38e-08 0.06 FALSE
Brain AABR07054000.1 isoform ratio ENSRNOT00000117007 0.04 1 0.02 3.2e-03 5.26 1.40e-07 0.03 FALSE
Eye Ism1 gene expression ENSRNOG00000063262 0.59 1704 0.07 3.4e-02 5.4 6.51e-08 0.23 FALSE
IL AABR07054000.1 gene expression ENSRNOG00000050784 0.21 1 0.04 3.1e-02 -5.45 5.15e-08 0.05 FALSE
IL AABR07054000.1 isoform ratio ENSRNOT00000117007 0.18 1 0.11 1.2e-03 5.32 1.04e-07 0.05 FALSE
IL Tasp1 mRNA stability ENSRNOG00000004493 0.14 1685 0.1 2.2e-03 -5.56 2.67e-08 0.4 FALSE
IL Ndufaf5 mRNA stability ENSRNOG00000004784 0.19 1 0.08 6.8e-03 5.35 8.90e-08 0.06 FALSE
LHb AABR07054000.1 gene expression ENSRNOG00000050784 0.23 97 0.17 9.3e-05 -5.24 1.56e-07 0.51 FALSE
LHb AABR07054000.1 intron excision ratio chr3:127725722:127747858 0.14 1 0.05 2.9e-02 -5.39 7.14e-08 0.05 FALSE
LHb AABR07054000.1 intron excision ratio chr3:127725722:127779334 0.13 1 0.03 6.5e-02 5.39 7.14e-08 0.05 FALSE
Liver Flrt3 alternative TSS ENSRNOT00000006454 0.03 2101 0.01 2.0e-02 6.01 1.89e-09 0.14 FALSE
Liver Flrt3 isoform ratio ENSRNOT00000006454 0.03 2101 0.01 6.6e-02 5.91 3.32e-09 0.1 FALSE
Liver AABR07054000.1 intron excision ratio chr3:127747955:127749007 0.03 25 0.02 5.2e-03 6.26 3.84e-10 0.3 FALSE
NAcc AABR07054000.1 alternative polyA ENSRNOT00000072928 0.08 1 0.03 1.7e-03 -5.15 2.60e-07 0.04 FALSE
NAcc AABR07054000.1 alternative polyA ENSRNOT00000110455 0.11 1836 0.01 2.5e-02 5.81 6.17e-09 0.12 FALSE
NAcc Tasp1 gene expression ENSRNOG00000004493 0.05 1 0.04 6.8e-04 5.2 2.03e-07 0.06 FALSE
NAcc Ndufaf5 gene expression ENSRNOG00000004784 0.06 1671 0.03 3.7e-03 5.89 3.96e-09 0.33 FALSE
NAcc AABR07054000.1 gene expression ENSRNOG00000050784 0.1 5 0.09 1.9e-07 -5.6 2.17e-08 0.22 FALSE
NAcc AABR07054000.1 isoform ratio ENSRNOT00000072928 0.07 1836 0.03 5.6e-03 -5.71 1.16e-08 0.19 FALSE
NAcc AABR07054000.1 isoform ratio ENSRNOT00000117007 0.06 1836 0.05 2.4e-04 5.42 5.80e-08 0.32 FALSE
NAcc Tasp1 intron excision ratio chr3:127385117:127399392 0.07 1 0.02 1.0e-02 -5.2 2.03e-07 0.22 FALSE
NAcc Ndufaf5 mRNA stability ENSRNOG00000004784 0.1 36 0.07 6.6e-06 5.46 4.83e-08 0.42 FALSE
OFC AABR07054000.1 alternative polyA ENSRNOT00000072928 0.21 1 0.1 2.4e-03 -5.28 1.32e-07 0.05 FALSE
OFC Ism1 gene expression ENSRNOG00000063262 0.24 1 0.12 1.1e-03 -5.17 2.34e-07 0.07 FALSE
OFC Tasp1 mRNA stability ENSRNOG00000004493 0.17 1 0.11 1.2e-03 -5.34 9.30e-08 0.06 FALSE
PL AABR07054000.1 alternative polyA ENSRNOT00000072928 0.17 1 0.17 1.1e-12 -5.39 7.07e-08 0.14 FALSE
PL AABR07054000.1 alternative polyA ENSRNOT00000117007 0.08 13 0.08 5.7e-07 5.35 8.68e-08 0.45 FALSE
PL Tasp1 gene expression ENSRNOG00000004493 0.04 8 0.02 1.0e-02 -5.77 7.70e-09 0.37 FALSE
PL Ndufaf5 gene expression ENSRNOG00000004784 0.16 24 0.08 5.9e-07 5.25 1.51e-07 0.06 FALSE
PL AABR07054000.1 gene expression ENSRNOG00000050784 0.09 1 0.11 6.0e-09 -5.32 1.03e-07 0.1 FALSE
PL AABR07054000.1 isoform ratio ENSRNOT00000072928 0.21 1 0.15 2.5e-11 -5.39 7.07e-08 0.14 FALSE
PL AABR07054000.1 isoform ratio ENSRNOT00000117007 0.1 1 0.12 3.1e-09 5.35 8.99e-08 0.11 FALSE
PL Tasp1 intron excision ratio chr3:127385117:127399392 0.04 1687 0.04 1.1e-03 -5.26 1.41e-07 0.47 FALSE
PL AABR07054000.1 intron excision ratio chr3:127725722:127747858 0.04 1 0.03 1.8e-03 -5.33 9.72e-08 0.04 FALSE
PL AABR07054000.1 intron excision ratio chr3:127725722:127779334 0.04 1 0.03 1.6e-03 5.33 9.72e-08 0.04 FALSE
PL Tasp1 mRNA stability ENSRNOG00000004493 0.04 1687 0.04 5.9e-04 -5.31 1.08e-07 0.51 FALSE
PL Ndufaf5 mRNA stability ENSRNOG00000004784 0.18 50 0.13 4.7e-10 5.36 8.31e-08 0.11 FALSE