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chr3:126,323,673-128,707,024

Trait: Retroperitoneal fat weight

Best TWAS P=1.767915e-10 · Best GWAS P=4.406814e-12 conditioned to 0.0006609294

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.26	0.13	blup	1836	0.16	2.6e-17	5.2	-5.5	3.0e-08	-0.82	0.59	0.41	FALSE
2	Adipose	AABR07054000.1	alternative polyA	ENSRNOT00000110455	0.08	0.06	lasso	22	0.06	5.7e-07	5.2	5.2	1.9e-07	0.71	0.61	0.39	FALSE
3	Adipose	AABR07054000.1	alternative polyA	ENSRNOT00000117007	0.07	0.04	top1	1	0.04	1.2e-05	5.3	5.3	9.9e-08	0.89	0.28	0.05	FALSE
4	Adipose	AABR07054000.1	gene expression	ENSRNOG00000050784	0.42	0.30	top1	1	0.30	4.0e-34	5.3	5.3	1.4e-07	0.78	0.92	0.07	FALSE
5	Adipose	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.28	0.15	lasso	59	0.19	8.1e-21	5.2	-5.5	3.7e-08	-0.85	0.48	0.52	FALSE
6	Adipose	AABR07054000.1	isoform ratio	ENSRNOT00000110455	0.09	0.06	blup	1836	0.06	1.8e-07	6.1	5.7	1.0e-08	0.81	0.58	0.42	FALSE
7	Adipose	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.15	0.08	enet	471	0.09	1.3e-10	5.3	5.5	3.7e-08	0.87	0.44	0.56	FALSE
8	Adipose	Esf1	mRNA stability	ENSRNOG00000004777	0.17	0.06	blup	1671	0.07	2.9e-08	-4.1	5.2	1.9e-07	0.51	0.99	0.01	FALSE
9	Adipose	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.04	0.00	enet	54	0.01	1.5e-02	4.8	5.2	2.2e-07	0.59	0.47	0.45	FALSE
10	BLA	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.14	0.08	blup	1836	0.09	1.9e-05	5.5	-6.0	1.7e-09	-0.84	0.53	0.47	FALSE
11	BLA	AABR07054000.1	alternative polyA	ENSRNOT00000117007	0.12	0.08	top1	1	0.08	7.2e-05	5.3	5.3	1.0e-07	0.87	0.10	0.04	FALSE
12	BLA	Flrt3	gene expression	ENSRNOG00000004874	0.06	0.04	top1	1	0.04	5.4e-03	5.2	-5.2	2.6e-07	-0.91	0.08	0.04	FALSE
13	BLA	AABR07054000.1	gene expression	ENSRNOG00000050784	0.09	0.02	enet	49	0.03	1.5e-02	5.2	-6.4	1.8e-10	-0.71	0.66	0.20	TRUE
14	BLA	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.15	0.14	blup	1836	0.15	2.4e-08	5.4	-5.9	3.6e-09	-0.82	0.76	0.24	FALSE
15	BLA	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.11	0.07	top1	1	0.07	1.1e-04	5.3	5.3	1.0e-07	0.85	0.16	0.04	FALSE
16	BLA	AABR07054000.1	intron excision ratio	chr3:127725722:127779334	0.06	0.03	top1	1	0.03	1.6e-02	5.6	5.6	1.8e-08	0.60	0.07	0.04	FALSE
17	BLA	Tasp1	mRNA stability	ENSRNOG00000004493	0.11	0.08	lasso	5	0.08	2.9e-05	5.2	-5.2	2.3e-07	-0.71	0.46	0.53	FALSE
18	Brain	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.03	0.02	top1	1	0.02	4.5e-03	5.3	-5.3	1.0e-07	-0.69	0.06	0.03	FALSE
19	Brain	AABR07054000.1	gene expression	ENSRNOG00000050784	0.04	0.05	top1	1	0.05	2.2e-05	6.1	-6.1	1.2e-09	-0.89	0.08	0.42	FALSE
20	Brain	Ism1	gene expression	ENSRNOG00000063262	0.05	0.03	enet	32	0.04	8.7e-05	4.8	-5.3	1.5e-07	-0.66	0.45	0.54	FALSE
21	Brain	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.04	0.04	top1	1	0.04	6.8e-05	5.4	-5.4	7.4e-08	-0.79	0.29	0.06	FALSE
22	Brain	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.04	0.02	top1	1	0.02	3.2e-03	5.3	5.3	1.4e-07	0.74	0.07	0.03	FALSE
23	Eye	Ism1	gene expression	ENSRNOG00000063262	0.59	0.02	blup	1704	0.07	3.4e-02	5.2	5.4	6.5e-08	0.63	0.22	0.23	FALSE
24	IL	AABR07054000.1	gene expression	ENSRNOG00000050784	0.21	0.05	top1	1	0.04	3.1e-02	5.4	-5.4	5.1e-08	-0.80	0.09	0.05	FALSE
25	IL	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.18	0.11	top1	1	0.11	1.2e-03	5.3	5.3	1.0e-07	0.87	0.10	0.05	FALSE
26	IL	Tasp1	mRNA stability	ENSRNOG00000004493	0.14	0.07	blup	1685	0.10	2.2e-03	5.2	-5.6	2.7e-08	-0.83	0.38	0.40	FALSE
27	IL	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.19	0.08	top1	1	0.08	6.8e-03	5.3	5.3	8.9e-08	0.72	0.09	0.06	FALSE
28	LHb	AABR07054000.1	gene expression	ENSRNOG00000050784	0.23	0.15	enet	97	0.17	9.3e-05	5.3	-5.2	1.6e-07	-0.73	0.44	0.51	FALSE
29	LHb	AABR07054000.1	intron excision ratio	chr3:127725722:127747858	0.14	0.05	top1	1	0.05	2.9e-02	5.4	-5.4	7.1e-08	-0.89	0.09	0.05	FALSE
30	LHb	AABR07054000.1	intron excision ratio	chr3:127725722:127779334	0.13	0.03	top1	1	0.03	6.5e-02	5.4	5.4	7.1e-08	0.89	0.09	0.05	FALSE
31	Liver	Flrt3	alternative TSS	ENSRNOT00000006454	0.03	0.01	blup	2101	0.01	2.0e-02	5.3	6.0	1.9e-09	0.85	0.48	0.14	FALSE
32	Liver	Flrt3	isoform ratio	ENSRNOT00000006454	0.03	0.01	blup	2101	0.01	6.6e-02	5.3	5.9	3.3e-09	0.82	0.44	0.10	FALSE
33	Liver	AABR07054000.1	intron excision ratio	chr3:127747955:127749007	0.03	0.01	enet	25	0.02	5.2e-03	5.2	6.3	3.8e-10	0.58	0.47	0.30	FALSE
34	NAcc	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.08	0.03	top1	1	0.03	1.7e-03	5.2	-5.2	2.6e-07	-0.72	0.16	0.04	FALSE
35	NAcc	AABR07054000.1	alternative polyA	ENSRNOT00000110455	0.11	0.00	blup	1836	0.01	2.5e-02	5.2	5.8	6.2e-09	0.81	0.64	0.12	FALSE
36	NAcc	Tasp1	gene expression	ENSRNOG00000004493	0.05	0.04	top1	1	0.04	6.8e-04	5.2	5.2	2.0e-07	0.74	0.08	0.06	FALSE
37	NAcc	Ndufaf5	gene expression	ENSRNOG00000004784	0.06	0.01	blup	1671	0.03	3.7e-03	5.1	5.9	4.0e-09	0.72	0.44	0.33	FALSE
38	NAcc	AABR07054000.1	gene expression	ENSRNOG00000050784	0.10	0.08	lasso	5	0.09	1.9e-07	5.9	-5.6	2.2e-08	-0.72	0.78	0.22	FALSE
39	NAcc	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.07	0.01	blup	1836	0.03	5.6e-03	5.2	-5.7	1.2e-08	-0.67	0.75	0.19	FALSE
40	NAcc	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.06	0.04	blup	1836	0.05	2.4e-04	5.3	5.4	5.8e-08	0.79	0.67	0.32	FALSE
41	NAcc	Tasp1	intron excision ratio	chr3:127385117:127399392	0.07	0.02	top1	1	0.02	1.0e-02	5.2	-5.2	2.0e-07	-0.81	0.24	0.22	FALSE
42	NAcc	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.10	0.05	lasso	36	0.07	6.6e-06	-4.1	5.5	4.8e-08	0.57	0.57	0.42	FALSE
43	OFC	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.21	0.10	top1	1	0.10	2.4e-03	5.3	-5.3	1.3e-07	-0.62	0.09	0.05	FALSE
44	OFC	Ism1	gene expression	ENSRNOG00000063262	0.24	0.12	top1	1	0.12	1.1e-03	5.2	-5.2	2.3e-07	-0.71	0.09	0.07	FALSE
45	OFC	Tasp1	mRNA stability	ENSRNOG00000004493	0.17	0.11	top1	1	0.11	1.2e-03	5.3	-5.3	9.3e-08	-0.79	0.09	0.06	FALSE
46	PL	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.17	0.17	top1	1	0.17	1.1e-12	5.4	-5.4	7.1e-08	-0.77	0.86	0.14	FALSE
47	PL	AABR07054000.1	alternative polyA	ENSRNOT00000117007	0.08	0.08	lasso	13	0.08	5.7e-07	5.4	5.4	8.7e-08	0.73	0.55	0.45	FALSE
48	PL	Tasp1	gene expression	ENSRNOG00000004493	0.04	0.01	enet	8	0.02	1.0e-02	-4.6	-5.8	7.7e-09	-0.41	0.42	0.37	FALSE
49	PL	Ndufaf5	gene expression	ENSRNOG00000004784	0.16	0.07	lasso	24	0.08	5.9e-07	-4.4	5.3	1.5e-07	0.48	0.94	0.06	FALSE
50	PL	AABR07054000.1	gene expression	ENSRNOG00000050784	0.09	0.11	top1	1	0.11	6.0e-09	5.3	-5.3	1.0e-07	-0.87	0.88	0.10	FALSE
51	PL	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.21	0.15	top1	1	0.15	2.5e-11	5.4	-5.4	7.1e-08	-0.77	0.86	0.14	FALSE
52	PL	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.10	0.12	top1	1	0.12	3.1e-09	5.3	5.3	9.0e-08	0.74	0.88	0.11	FALSE
53	PL	Tasp1	intron excision ratio	chr3:127385117:127399392	0.04	0.03	blup	1687	0.04	1.1e-03	5.3	-5.3	1.4e-07	-0.60	0.43	0.47	FALSE
54	PL	AABR07054000.1	intron excision ratio	chr3:127725722:127747858	0.04	0.03	top1	1	0.03	1.8e-03	5.3	-5.3	9.7e-08	-0.86	0.07	0.04	FALSE
55	PL	AABR07054000.1	intron excision ratio	chr3:127725722:127779334	0.04	0.03	top1	1	0.03	1.6e-03	5.3	5.3	9.7e-08	0.87	0.08	0.04	FALSE
56	PL	Tasp1	mRNA stability	ENSRNOG00000004493	0.04	0.04	blup	1687	0.04	5.9e-04	5.3	-5.3	1.1e-07	-0.84	0.46	0.51	FALSE
57	PL	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.18	0.09	lasso	50	0.13	4.7e-10	-4.2	5.4	8.3e-08	0.53	0.89	0.11	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.