Hub : Genes

Mpped2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Mpped2 0.07 0.05 6.9e-07 0.05 0.05 0.05 0.05 3.3e-06 1.4e-06 3.1e-06 1.2e-06
2 PL gene expression Mpped2 0.1 0.07 3.4e-08 0.08 0.07 0.07 0.08 5.1e-09 1.4e-08 1.5e-08 1.1e-08
3 BLA gene expression Mpped2 0.14 0.08 7.4e-09 0.13 0.16 0.14 0.14 1.3e-07 1.2e-08 9.2e-08 5.4e-08
4 Brain gene expression Mpped2 0.11 0.08 1.1e-11 0.1 0.13 0.13 0.13 3.3e-09 9.4e-12 5.4e-12 9.4e-12
5 NAcc gene expression Mpped2 0.1 0.07 3.4e-14 0.1 0.12 0.12 0.12 3.1e-11 1.1e-13 1.5e-13 6.0e-14
6 Brain mRNA stability Mpped2 0.1 0.1 2.7e-05 0.06 0.04 0.05 0.06 1.6e-06 4.6e-05 1.7e-05 4.7e-06
7 pVTA gene expression Mpped2 0.17 0.16 2.2e-05 0.08 0.12 0.13 0.13 2.9e-04 9.5e-06 2.4e-06 4.5e-06
8 Eye gene expression Mpped2 0.33 0.19 2.6e-03 0.19 0.14 0.1 0.17 6.7e-04 3.4e-03 1.3e-02 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.11.82.71.6-1.51.3-1.11.41.3-1.4-1.2
Area under the delay curve0.30.40.90.5-0.10.6-0.50.50.9-0.0-0.9
BMI with tail0.30.81.81.2-1.3-0.00.40.0-1.30.21.2
BMI without tail0.91.94.82.0-2.21.4-1.21.30.6-0.9-0.6
Body weight1.14.712.03.5-3.32.1-1.72.00.5-1.6-0.5
Weight adjusted by age0.60.71.51.2-0.40.9-0.90.60.9-0.4-0.9
Bone surface1.32.43.21.8-1.71.5-1.41.61.5-1.4-1.4
Bone volume1.72.94.32.1-1.91.8-1.61.71.6-1.4-1.4
Breakpoint value in progressive ratio session0.10.10.3-0.40.30.1-0.2-0.20.0-0.5-0.0
Number of licking bursts0.20.30.80.8-0.90.3-0.40.4-0.0-0.50.1
Context. condit. distance diff. score1.82.23.92.0-1.91.4-1.21.40.9-1.7-0.8
Locomotion velocity, session 11.31.42.4-1.61.5-1.10.9-1.2-0.91.50.7
Locomotion distance, session 10.30.41.0-1.01.0-0.50.3-0.5-0.01.0-0.1
Locomotion velocity, session 20.20.30.6-0.30.3-0.50.6-0.5-0.80.30.7
Locomotion distance, session 20.20.30.7-0.60.70.0-0.2-0.10.60.8-0.6
Locomotion velocity, session 30.20.30.50.1-0.10.6-0.70.50.6-0.3-0.7
Locomotion distance, session 31.41.53.50.3-0.21.3-1.51.11.9-0.5-1.8
Stereotopy head waving bouts, day 30.40.51.2-0.30.1-0.60.8-0.7-1.10.21.0
Stereotopy head waving duration, day 30.60.72.10.3-0.4-0.60.8-0.6-1.50.11.3
Locomotion velocity, session 70.40.41.40.5-0.40.6-0.50.60.5-1.2-0.4
Locomotion distance, session 70.10.20.50.10.00.3-0.40.40.7-0.3-0.6
Stereotopy head waving bouts, day 70.40.51.0-1.00.9-0.70.7-0.8-0.40.40.3
Stereotopy head waving duration, day 70.20.30.5-0.70.7-0.50.5-0.6-0.30.20.2
Locomotion velocity, session 80.10.10.20.4-0.40.4-0.40.20.30.3-0.2
Locomotion distance, session 81.11.72.31.3-1.11.4-1.41.31.5-0.8-1.4
Degree of sensitization distance1.21.22.6-0.50.4-1.21.4-1.0-1.50.51.6
Degree of sensitization stereotypy0.50.51.2-1.11.1-0.70.6-0.8-0.10.50.1
Conditioned locomotion2.32.73.0-1.71.6-1.71.6-1.7-1.51.71.5
Cocaine response after cond. corrected6.26.98.1-2.82.7-2.72.7-2.7-2.32.82.1
Cocaine response after cond. not corrected2.12.33.4-1.81.8-1.41.5-1.5-1.21.81.0
Cocaine response before conditioning7.89.410.73.1-2.83.3-3.33.23.0-2.9-2.9
Saline control response1.31.72.70.9-0.81.4-1.61.31.6-0.7-1.6
Bone: connectivity density0.81.21.81.1-1.01.0-0.81.11.3-1.1-1.2
Bone: cortical apparent density0.10.10.3-0.40.30.3-0.50.30.5-0.2-0.4
Bone: cortical area0.81.22.91.7-1.61.1-0.81.00.8-0.9-0.5
Bone: cortical porosity0.10.10.3-0.40.4-0.30.3-0.3-0.3-0.30.5
Bone: cortical porosity0.20.20.60.4-0.40.5-0.60.50.4-0.8-0.2
Bone: cortical thickness0.10.10.40.6-0.60.3-0.20.20.3-0.20.1
Bone: cortical thickness0.20.30.7-0.70.5-0.40.3-0.4-0.10.80.4
Bone: cortical tissue density0.10.20.4-0.40.30.4-0.50.40.6-0.3-0.6
Condit. Reinf. active minus inactive responses2.93.35.41.3-1.22.1-2.31.82.1-0.8-2.2
Condit. Reinf. active-inactive response ratio4.85.27.12.4-2.22.6-2.72.42.1-1.3-2.3
Condit. Reinf. active responses1.92.34.40.7-0.61.8-1.91.42.0-1.0-2.1
Condit. Reinf. inactive responses0.30.30.9-0.91.0-0.30.3-0.40.2-0.5-0.3
Incentive salience index mean2.83.45.61.2-1.12.2-2.41.82.2-1.0-2.3
Condit. Reinf. lever presses1.31.72.80.8-0.71.5-1.61.21.6-1.0-1.7
Condit. Reinf. active minus inactive responses3.23.95.51.8-1.52.1-2.12.12.3-1.6-2.2
Condit. Reinf. active-inactive response ratio4.64.86.02.2-1.82.4-2.42.32.4-1.6-2.3
Condit. Reinf. active responses2.83.95.31.8-1.62.0-2.12.02.3-1.8-2.1
Condit. Reinf. inactive responses0.40.51.00.7-0.80.7-0.60.70.7-1.0-0.5
Condit. Reinf. lever presses3.14.35.62.1-1.92.2-2.12.02.4-1.5-2.2
Condit. Reinf. lever reinforcers received2.84.05.11.9-1.72.1-2.12.02.3-1.8-2.1
Conditioned reinforcement - actives1.81.83.11.8-1.31.6-1.71.31.10.2-1.0
Conditioned reinforcement - inactives2.73.14.61.9-2.11.8-1.71.51.9-0.6-1.9
Conditioned locomotion1.41.73.01.7-1.21.5-1.51.31.20.6-1.1
Patch foraging indifference point 0 sec0.00.10.20.2-0.20.2-0.20.10.4-0.4-0.3
Patch foraging indifference point AUC1.41.64.7-2.22.0-0.40.0-0.60.81.5-0.8
Delay disc. indifference point, 0s delay0.70.71.51.1-1.20.7-0.70.90.8-0.6-0.6
Delay disc. indifference point, 16s delay0.10.10.30.00.50.2-0.1-0.00.30.5-0.3
Delay disc. indifference point, 2s delay0.60.71.91.3-1.40.7-0.50.70.8-0.3-0.5
Delay disc. indifference point, 24s delay0.60.60.8-0.70.8-0.80.9-0.9-0.50.90.5
Delay disc. indifference point, 4s delay1.21.22.50.7-0.61.1-1.11.21.6-0.7-1.5
Delay disc. indifference point, 8s delay0.70.71.20.8-0.11.0-0.80.91.1-0.5-1.0
Indifference point function ln k1.52.15.82.4-2.11.1-0.91.3-0.4-1.60.4
Indifference point function log k1.52.15.82.4-2.11.1-0.91.3-0.4-1.60.4
Patch foraging total patch changes 0 sec0.00.10.10.3-0.20.2-0.20.20.3-0.4-0.2
Patch foraging total patch changes 12 sec0.60.82.2-0.1-0.00.8-1.10.71.5-0.2-1.3
Patch foraging total patch changes 18 sec0.20.20.5-0.70.6-0.1-0.0-0.20.70.2-0.6
Patch foraging total patch changes 24 sec1.11.31.71.1-1.11.2-1.21.11.3-0.9-1.3
Patch foraging total patch changes 6 sec0.50.82.10.10.10.9-1.00.71.4-0.4-1.2
Patch foraging time to switch 0 sec0.10.10.30.6-0.5-0.10.10.1-0.2-0.50.3
Patch foraging water rate 0 sec0.20.30.50.4-0.40.6-0.60.50.7-0.4-0.7
Patch foraging water rate 12 sec1.11.63.51.9-1.81.2-1.01.20.7-1.3-0.6
Patch foraging water rate 18 sec1.52.04.32.1-1.91.5-1.31.40.9-0.9-0.8
Patch foraging water rate 24 sec1.31.82.91.7-1.51.7-1.61.60.7-0.6-0.6
Patch foraging water rate 6 sec0.20.30.70.8-0.70.6-0.40.50.3-0.6-0.3
Seeking ratio, delayed vs. immediate footshock4.04.65.42.1-2.02.3-2.32.32.2-1.8-2.2
Distance traveled before self-admin0.40.51.20.4-0.70.4-0.70.50.7-1.1-0.6
Distance traveled after self-admin3.33.74.72.0-2.01.9-2.01.91.7-2.2-1.6
Extensor digitorum longus weight0.00.10.2-0.20.3-0.10.0-0.1-0.40.00.3
Bone: elastic displacement0.70.81.4-1.21.1-0.80.7-0.9-0.51.20.5
Bone: elastic work0.00.10.20.3-0.20.1-0.10.1-0.20.40.2
Bone: endosteal estimation0.10.20.60.4-0.4-0.20.3-0.2-0.80.10.6
Bone: endosteal perimeter0.61.32.31.5-1.41.2-1.11.10.9-0.9-0.9
Epididymis fat weight1.33.15.92.4-2.31.9-1.61.71.2-1.2-1.2
Delta time in closed arm before/after self-admin0.40.41.4-0.60.6-0.60.3-0.3-0.41.20.4
Delta time in open arm before/after self-admin1.61.62.1-1.41.1-1.11.2-1.3-1.40.91.4
Diff in mean of infusions in LGA sessions1.31.52.61.2-1.11.2-1.11.01.6-0.4-1.6
Delay discount exponential model param0.30.30.8-0.4-0.0-0.60.5-0.5-0.90.10.8
Extinction: sum of active levers before priming0.60.60.90.4-0.30.9-1.00.80.9-0.5-1.0
Active lever presses in extinction session 61.91.82.61.6-1.31.4-1.41.31.3-1.2-1.3
Bone: final force0.60.92.11.5-1.20.9-0.81.00.7-0.8-0.6
Bone: final moment0.40.71.71.3-1.00.8-0.70.80.4-0.7-0.4
Food consumed during 24 hour testing period1.11.32.21.5-1.51.2-1.21.10.8-1.0-0.7
Glucose0.50.81.30.9-0.61.0-1.11.01.0-0.2-0.9
Heart weight2.43.46.12.2-2.01.8-1.82.01.0-2.5-1.0
Delay discount hyperbolic model param0.40.41.0-0.50.2-0.70.6-0.6-1.00.20.9
Intermittent access intake day 1-15 change0.20.20.7-0.60.8-0.0-0.2-0.10.10.4-0.1
Intermittent access intake escalation0.20.20.8-0.50.90.1-0.40.00.20.6-0.3
Intermittent access intake escalation 20.30.30.70.20.30.5-0.70.50.80.2-0.9
Intermitt. access day 1 inactive lever presses0.10.20.40.0-0.10.5-0.50.30.4-0.1-0.6
Intermitt. access day 15 inactive lever presses0.40.51.10.3-0.30.7-0.60.50.8-1.0-0.9
Intermitt. access escalation Index1.00.91.7-1.31.3-0.90.8-0.8-0.8-0.70.7
Intermittent access day 1 total infusions0.70.81.41.1-1.21.0-1.10.70.50.8-0.5
Intermittent access day 15 total infusions0.60.61.30.6-0.60.9-1.10.50.71.0-0.8
Intermittent access terminal intake (last 3 days)0.60.71.30.7-0.70.9-1.10.50.90.4-0.9
Intermittent access total infusions0.80.91.41.1-1.21.1-1.20.60.70.8-0.8
Intermittent access day 1 locomotion0.40.42.50.7-0.50.2-0.0-0.2-0.01.60.1
Intermittent access day 15 total locomotion0.30.31.90.20.10.3-0.30.10.21.4-0.2
Intermittent access total locomotion0.30.42.70.30.00.1-0.0-0.10.11.7-0.0
Intermittent access standard deviation1.01.01.41.0-1.11.0-1.10.81.10.8-1.2
Left kidney weight0.82.36.92.6-2.31.5-1.21.60.1-0.3-0.1
Right kidney weight1.54.310.13.2-2.82.2-2.02.20.7-1.2-0.7
Cocaine induced anxiety0.20.30.80.9-0.60.2-0.10.20.4-0.7-0.3
Post-drug Anxiety3.53.95.32.3-2.01.8-1.81.91.9-2.2-1.9
Baseline Anxiety0.70.81.40.7-0.81.1-1.20.90.8-0.3-0.9
Tail length2.16.27.82.8-2.82.6-2.52.52.4-1.8-2.3
Length with tail1.45.19.33.1-2.72.4-2.22.31.6-1.7-1.5
Length without tail0.30.72.11.4-1.00.9-0.70.80.0-0.7-0.0
Times rat made contact with spout0.50.61.20.2-0.30.8-1.10.71.10.4-1.1
Lifetime Intake0.30.31.00.5-0.50.6-0.70.10.11.0-0.2
Liver weight, left1.52.35.12.3-2.01.5-1.31.60.8-1.4-0.7
Liver weight, right3.66.08.83.0-2.72.6-2.32.42.0-2.8-1.7
Locomotor activity0.30.40.7-0.20.4-0.80.8-0.7-0.50.90.7
Locomotor testing distance0.20.31.31.2-0.80.3-0.00.30.1-0.30.0
Locomotor testing rearing0.20.30.80.9-0.80.3-0.10.50.50.3-0.4
Locomotion in novel chamber2.02.43.61.9-1.71.3-1.31.41.6-1.6-1.6
Locomotion in novel chamber post-restriction0.20.20.8-0.90.6-0.30.2-0.5-0.00.3-0.0
Fecal boli incidents, locomotor time 14.14.46.1-2.42.1-2.32.4-2.5-2.00.52.0
Change in fecal boli incidents, locomotor task3.43.24.41.9-1.82.0-2.12.11.7-0.7-1.6
Time >=10cm from walls, locomotor time 11.31.34.8-0.91.0-0.90.8-0.8-0.82.20.8
Bouts of movement, locomotor time 10.80.92.4-1.41.6-0.90.9-0.9-0.40.50.3
Total resting periods, locomotor time 11.41.53.3-1.81.8-1.21.2-1.3-0.70.60.6
Rest time, locomotor task time 11.21.32.3-1.51.4-1.11.1-1.3-0.81.10.6
Distance moved, locomotor task time 12.32.53.51.8-1.61.7-1.81.91.5-0.8-1.4
Vertical activity count, locomotor time 11.51.63.11.8-1.71.3-1.21.40.9-0.4-0.8
Time >=10cm from walls, locomotor time 24.14.36.62.6-2.22.2-2.22.22.0-0.8-1.9
Bouts of movement, locomotor time 20.50.50.80.5-0.50.6-0.60.60.9-0.8-0.9
Total resting periods, locomotor time 20.20.20.50.00.00.4-0.40.40.6-0.7-0.7
Rest time, locomotor task time 26.67.613.1-3.63.3-2.72.7-2.7-2.42.22.3
Distance moved, locomotor task time 26.57.59.52.9-2.62.9-3.12.82.8-1.6-2.8
Vertical activity count, locomotor time 28.29.014.13.7-3.43.1-3.03.02.8-1.9-2.6
Light reinforcement 10.61.01.80.7-0.51.2-1.31.01.40.6-1.2
Light reinforcement 21.41.96.0-1.51.2-1.11.0-1.3-0.82.40.8
Bone: marrow area0.10.20.60.4-0.4-0.20.3-0.2-0.80.10.6
Bone: maximum diameter0.30.61.41.2-1.10.7-0.50.60.6-0.6-0.4
Bone: maximum force0.71.33.31.8-1.61.1-0.91.00.5-0.9-0.4
Bone: maximum moment0.50.92.51.6-1.41.0-0.70.90.3-0.8-0.2
Mean time between licks in bursts0.00.00.2-0.10.1-0.10.0-0.2-0.10.4-0.1
Mean num. licks in bursts0.20.30.6-0.70.70.1-0.2-0.10.50.8-0.6
Cd content in liver0.70.82.4-0.20.40.7-0.90.51.5-0.0-1.5
Co content in liver0.91.13.4-1.71.8-0.90.6-0.80.00.80.1
Cu content in liver0.60.71.5-1.21.2-1.00.9-0.8-0.20.40.5
Fe content in liver0.20.30.5-0.70.7-0.60.4-0.5-0.30.40.3
K content in liver0.10.10.2-0.30.30.1-0.10.20.5-0.4-0.4
Mg content in liver0.20.20.5-0.70.7-0.20.1-0.10.3-0.2-0.2
Mn content in liver0.80.92.0-1.41.4-0.80.7-0.8-0.31.00.4
Na content in liver0.50.51.20.2-0.40.8-0.90.71.1-0.4-0.8
Rb content in liver0.40.51.9-1.21.4-0.40.2-0.40.40.4-0.4
Se content in liver1.31.61.9-1.21.1-1.41.3-1.3-1.41.11.4
Sr content in liver0.10.10.10.3-0.30.3-0.30.30.3-0.3-0.0
Zn content in liver0.50.61.6-1.21.3-0.60.4-0.50.10.70.1
Bone: minimum diameter1.32.55.02.2-2.11.7-1.51.50.9-1.0-0.9
Time in familiar zone, hab. session 10.60.51.0-0.91.0-0.80.7-0.70.11.00.2
Time in novel zone, hab. session 10.80.71.41.2-1.21.1-1.10.80.3-0.0-0.5
Total zone transitions, hab. session 11.21.62.41.2-1.01.4-1.51.31.5-0.5-1.5
Total locomotion distance, hab. session 10.10.10.70.00.10.1-0.20.00.40.8-0.3
Locomotion velocity, hab. session 10.00.10.5-0.00.10.0-0.1-0.0-0.00.7-0.1
Time in familiar zone, hab. session 20.00.00.1-0.20.2-0.20.1-0.10.00.40.1
Time in novel zone, hab. session 20.10.10.40.6-0.60.4-0.30.2-0.10.1-0.0
Total zone transitions, hab. session 20.20.21.00.00.00.4-0.60.20.41.0-0.4
Total locomotion distance, hab. session 21.21.53.6-1.11.0-1.10.9-1.2-1.11.91.3
Locomotion velocity, hab. session 21.01.43.5-1.11.1-1.00.8-1.2-0.91.91.1
Novel to familiar place preference ratio0.50.51.41.2-1.00.6-0.50.60.4-0.2-0.5
Novelty place preference0.60.61.51.2-1.10.7-0.70.70.6-0.3-0.6
Time in novel zone, NPP test0.50.61.41.2-1.00.7-0.70.70.50.1-0.5
Total zone transitions, NPP test0.81.13.0-1.51.4-0.70.4-0.9-0.31.70.3
Total locomotion distance, NPP test1.01.43.0-1.41.3-1.10.9-1.2-0.91.70.9
Locomotion velocity, NPP test0.91.31.7-1.31.2-1.21.1-1.1-1.01.10.9
Intraocular pressure1.31.72.5-1.41.1-1.61.6-1.4-1.50.71.1
Delta distance traveled before/after self-admin0.20.20.40.5-0.30.6-0.40.50.3-0.4-0.3
Delta ambulatory time before/after self-admin0.40.40.70.7-0.40.8-0.60.70.5-0.8-0.5
Parametrial fat weight0.20.40.90.8-0.90.6-0.60.60.1-0.9-0.1
Pavlov. Cond. lever latency0.30.40.6-0.20.2-0.60.7-0.7-0.80.60.8
Pavlov. Cond. magazine entry latency1.21.52.01.1-0.91.3-1.41.21.4-1.1-1.4
Pavlov. Cond. change in total contacts1.21.32.80.2-0.21.2-1.31.11.7-0.9-1.7
Pavlov. Cond. index score0.60.71.30.3-0.30.9-1.10.81.1-0.7-1.1
Pavlov. Cond. latency score0.50.61.10.2-0.20.8-1.00.71.0-0.6-1.0
Pavlov. Cond. lever contacts0.50.60.90.3-0.20.8-0.90.80.9-0.7-0.9
Pavlov. Cond. magazine entry number1.82.33.5-0.90.8-1.61.8-1.5-1.81.41.9
Pavlov. Cond. intertrial magazine entries0.91.01.40.8-0.71.2-1.21.11.0-0.9-1.1
Pavlov. Cond. lever-magazine prob. diff.0.60.71.40.2-0.20.9-1.00.81.2-0.7-1.2
Pavlov. Cond. response bias0.91.01.60.5-0.41.1-1.31.01.2-1.1-1.2
Pavlov. Cond. lever latency3.95.36.2-2.42.2-2.42.5-2.3-2.51.42.4
Pavlov. Cond. magazine entry latency0.70.81.21.0-0.90.8-0.81.00.9-0.3-1.1
Pavlov. Cond. change in total contacts1.62.23.41.3-1.21.6-1.81.61.7-0.2-1.8
Pavlov. Cond. index score3.34.24.92.2-2.02.2-2.22.12.2-1.0-2.2
Pavlov. Cond. latency score3.74.65.62.3-2.12.3-2.42.22.3-1.0-2.4
Pavlov. Cond. lever contacts4.56.17.62.5-2.32.7-2.72.42.7-1.3-2.7
Pavlov. Cond. magazine entry number1.61.92.7-1.51.3-1.31.3-1.5-1.50.81.6
Pavlov. Cond. intertrial magazine entries0.60.72.71.1-1.10.5-0.30.6-0.1-1.70.2
Pavlov. Cond. lever-magazine prob. diff.3.03.94.62.1-1.92.1-2.12.02.1-0.9-2.1
Pavlov. Cond. response bias3.44.65.52.3-2.12.2-2.32.22.3-1.2-2.3
Time in closed arm before self-admin2.02.34.21.6-1.61.5-1.41.41.2-2.1-1.2
Time in closed arm after self-admin1.11.12.31.4-1.50.9-0.91.10.8-1.0-0.7
Time in open arm before self-admin0.10.10.3-0.20.5-0.0-0.20.20.3-0.3-0.3
Time in open arm after self-admin0.40.41.3-1.11.1-0.50.3-0.5-0.40.20.4
Bone: periosteal estimation0.20.41.51.2-1.10.5-0.30.40.1-0.40.0
Bone: periosteal perimeter0.81.32.61.6-1.41.1-1.01.11.0-0.9-0.9
Bone: post-yield work0.10.20.50.6-0.70.5-0.50.40.20.1-0.2
Progressive ratio test 1 active lever presses0.20.20.60.2-0.10.7-0.80.30.3-0.2-0.4
Progressive ratio test 1 breakpoint0.10.20.50.2-0.10.6-0.70.30.3-0.2-0.4
Progressive ratio test 1 inactive lever presses0.20.31.6-0.5-0.0-0.10.0-0.4-0.31.30.1
Progressive ratio test 2 active lever presses0.40.40.60.8-0.70.7-0.70.40.70.2-0.7
Progressive ratio test 2 breakpoint0.91.01.51.1-1.01.1-1.20.81.2-0.1-1.1
Progressive ratio test 2 inactive lever presses1.21.32.41.5-1.61.1-1.00.91.2-0.5-1.2
Incentive Sensitization - Responses0.00.00.1-0.1-0.2-0.10.1-0.30.1-0.1-0.1
Incentive Sensitization - Breakpoint0.00.00.1-0.1-0.2-0.10.1-0.30.1-0.0-0.0
Sum of active levers in priming session hrs 5-60.20.20.60.6-0.5-0.00.1-0.0-0.3-0.80.4
Progressive ratio0.80.91.8-0.40.3-1.01.2-1.1-1.20.21.3
Food seeking constrained by brief footshock0.10.20.4-0.20.2-0.50.4-0.4-0.5-0.30.7
Seeking ratio, punishment vs. effort0.10.10.2-0.30.30.2-0.40.30.3-0.1-0.4
Retroperitoneal fat weight11.236.759.87.7-7.06.1-5.86.34.3-6.2-4.2
Reaction time number correct1.11.62.21.4-1.31.4-1.51.50.8-1.0-0.9
Reaction time mean minus median0.00.00.0-0.0-0.20.2-0.20.0-0.0-0.1-0.1
Reaction time mean minus median AUC0.40.60.80.6-0.80.9-0.90.70.7-0.6-0.8
Reaction time num false alarms0.10.20.5-0.30.60.1-0.20.30.60.1-0.7
Reaction time num false alarms AUC0.10.20.8-0.60.9-0.1-0.00.00.40.1-0.5
Reaction time trials correct on left1.11.62.21.4-1.31.4-1.51.50.8-1.0-0.9
Reaction time trials on left1.01.42.11.3-1.21.4-1.41.40.8-1.0-0.9
Reaction time mean0.10.20.40.3-0.60.4-0.50.4-0.3-0.60.2
Reaction time mean AUC0.20.30.70.5-0.80.6-0.70.6-0.1-0.80.0
Median of all reaction times0.20.30.60.4-0.70.4-0.50.5-0.3-0.80.2
Reaction time omissions0.40.61.4-1.21.0-0.60.6-0.6-0.50.70.4
Reaction time false alarm rate0.50.72.0-1.31.4-0.80.7-0.7-0.10.6-0.1
Reaction time premature initiation rate0.20.20.4-0.60.70.1-0.2-0.00.60.3-0.6
Reaction time premature initiations0.20.30.7-0.10.20.6-0.80.50.8-0.1-0.8
Std. dev. reaction times0.10.20.50.4-0.70.5-0.50.4-0.0-0.3-0.1
Reaction time trials completed1.01.42.11.3-1.21.4-1.41.40.8-1.0-0.9
Reaction time trials AUC1.11.62.41.4-1.21.5-1.61.50.9-1.1-0.9
Run reversals in cocaine runway, females1.21.11.71.3-1.01.1-1.01.00.9-1.3-0.9
Run reversals in cocaine runway, males1.71.63.6-1.41.6-1.11.1-1.4-0.61.90.5
Latency to leave start box in cocaine runway0.10.10.6-0.80.2-0.30.2-0.2-0.10.30.1
Latency to leave start box in cocaine runway, F0.60.61.2-1.10.6-0.80.7-0.7-0.80.70.9
Latency to leave start box in cocaine runway, M0.20.20.5-0.10.00.3-0.40.40.7-0.3-0.6
Std. dev. time between licks in bursts1.82.23.41.8-1.71.7-1.71.51.1-0.9-1.1
Total sessions with >9 infusions0.70.82.1-0.1-0.1-0.40.3-0.7-1.21.51.4
Short access day 1 total inactive lever presses0.20.31.00.7-1.00.20.10.10.0-0.8-0.1
Short access day 10 total inactive lever presses0.91.01.40.9-0.91.0-1.11.21.0-0.8-1.1
Short access day 1 total infusions0.20.20.60.5-0.40.6-0.80.40.20.0-0.2
Short access day 10 total infusions0.20.31.3-0.1-0.00.1-0.2-0.4-0.61.20.5
Short access total infusions0.40.52.1-0.20.0-0.20.0-0.6-0.71.50.8
Short access day 1 locomotion0.30.42.3-0.10.3-0.20.2-0.4-0.21.50.4
Short access day 10 total locomotion0.50.62.9-0.50.9-0.40.5-0.6-0.31.70.2
Short access total locomotion0.50.53.80.4-0.10.3-0.20.10.41.9-0.3
One hour access (0.3 mA shock)0.80.91.70.50.01.1-1.30.81.10.7-1.2
Compulsive drug intake0.70.72.0-1.41.0-0.80.8-0.9-0.20.3-0.0
One hour access (shock baseline)1.31.52.91.5-0.81.6-1.71.21.1-0.0-1.1
Social response proportion2.12.34.6-1.81.7-1.31.4-1.6-0.92.10.8
Social responses0.60.71.50.20.20.8-0.90.51.21.0-1.2
Social time4.86.311.8-3.43.2-2.21.9-2.5-1.33.21.2
Soleus weight0.30.71.5-0.70.6-0.80.9-0.9-1.20.61.1
Bone: stiffness0.60.92.61.6-1.50.8-0.60.90.1-1.0-0.1
Tibialis anterior weight0.93.14.3-2.02.1-1.81.8-1.8-1.71.51.5
Time to tail flick, vehicle, before self-admin0.20.20.60.1-0.60.1-0.00.30.3-0.8-0.3
Time to tail flick, vehicle, after self-admin1.82.02.31.4-1.21.4-1.51.41.5-1.4-1.5
Time to tail flick, test, before self-admin0.60.52.00.00.10.6-0.70.50.7-1.4-0.8
Time to tail flick, test, after self-admin0.50.51.2-0.90.7-0.60.7-0.6-0.5-1.10.4
Delta time to tail flick, vehicle, before/after SA2.12.13.21.8-1.21.5-1.51.41.2-1.5-1.2
Delta time to tail flick, test, before/after SA2.22.03.0-1.20.9-1.41.7-1.5-1.41.61.5
Tibia length0.10.20.4-0.60.6-0.30.4-0.40.40.4-0.3
Ambulatory time before self-admin0.80.82.10.7-1.10.6-0.90.70.8-1.5-0.8
Ambulatory time after self-admin3.64.05.12.1-1.92.1-2.22.11.7-2.2-1.6
Bone: tissue strength1.81.72.5-1.01.1-1.21.3-1.2-1.61.51.5
Total heroin consumption0.40.40.9-0.70.9-0.50.6-0.7-0.50.50.6
Bone: trabecular number1.52.32.91.7-1.51.5-1.31.51.6-1.6-1.4
Bone: trabecular spacing0.40.50.9-0.80.7-0.70.7-0.7-0.51.00.5
Bone: trabecular thickness0.81.01.41.2-1.11.1-1.01.00.9-0.9-0.9
Bone: trabecular tissue density0.50.61.5-0.80.7-0.80.8-0.8-0.41.20.5
Water consumed over 24 hours0.10.10.50.2-0.40.2-0.30.1-0.10.70.0
Number of responses in last shaping day1.11.11.91.0-0.91.3-1.41.10.9-0.9-0.8