Hub : Genes

Mpped2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Mpped2 0.1 0.07 2.3e-07 0.06 0.07 0.06 0.06 5.1e-07 5.0e-08 3.0e-07 2.3e-07
2 Adipose gene expression Mpped2 0.08 0.06 1.5e-06 0.05 0.05 0.04 0.05 7.8e-06 1.7e-06 8.4e-06 2.9e-06
3 pVTA alternative TSS XM_006234681.5 0.02 0.02 7.7e-03 0.02 0.02 0 0.02 4.8e-03 1.2e-02 1.8e-01 1.9e-02
4 NAcc gene expression Mpped2 0.09 0.05 0.0e+00 0.13 0.14 0.14 0.14 1.2e-18 6.7e-21 7.3e-21 9.8e-21
5 BLA gene expression Mpped2 0.13 0.07 1.4e-08 0.12 0.16 0.13 0.14 5.8e-07 9.9e-09 1.4e-07 1.0e-07
6 Brain isoform ratio XM_039105449.2 0.02 0.02 3.7e-03 0 0 0 -0 2.6e-01 1.3e-01 2.5e-01 3.8e-01
7 Brain gene expression Mpped2 0.13 0.09 2.0e-12 0.13 0.13 0.13 0.14 9.4e-12 1.8e-12 2.6e-12 1.0e-12
8 Brain mRNA stability Mpped2 0.08 0.07 5.4e-05 0.05 0.04 0.04 0.05 2.9e-05 6.9e-05 2.7e-04 1.4e-05
9 Eye gene expression Mpped2 0.29 0.18 4.2e-03 0.17 0.13 0.08 0.16 1.5e-03 4.5e-03 2.6e-02 1.7e-03
10 pVTA gene expression Mpped2 0.12 0.1 4.5e-07 0.08 0.06 0.06 0.07 3.5e-07 1.5e-05 1.4e-05 1.9e-06
11 pVTA mRNA stability Mpped2 0.2 0.13 5.3e-03 0.01 0 0 0 4.2e-02 2.9e-01 2.6e-01 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.71.32.31.41.31.51.21.21.11.0-0.90.80.8-0.7
Area under the delay curve0.60.71.30.40.40.60.70.80.80.7-1.11.11.1-1.0
BMI with tail0.20.71.31.21.00.2-0.1-0.2-0.3-0.61.1-1.1-1.11.2
BMI without tail0.82.58.12.82.71.81.71.41.41.2-0.60.60.5-0.5
Body weight1.14.613.13.63.52.72.32.12.01.6-0.80.70.6-0.6
Weight adjusted by age0.71.01.50.70.71.01.01.01.01.0-1.01.21.0-1.2
Bone surface1.01.83.11.51.51.81.51.41.41.4-1.01.11.0-0.9
Bone volume1.32.34.21.91.82.01.71.71.61.5-1.01.11.0-0.9
Breakpoint value in progressive ratio session0.20.20.8-0.9-0.9-0.3-0.4-0.3-0.3-0.30.1-0.4-0.00.5
Number of licking bursts0.20.41.21.11.10.50.60.40.50.6-0.20.30.2-0.4
Context. condit. distance diff. score1.51.83.61.91.91.51.51.31.31.2-0.80.90.7-1.0
Locomotion velocity, session 11.01.12.6-1.6-1.6-1.4-1.2-1.1-1.1-0.90.3-0.5-0.20.6
Locomotion distance, session 10.40.51.6-1.3-1.2-0.8-0.6-0.5-0.5-0.3-0.20.10.3-0.2
Locomotion velocity, session 20.20.20.5-0.0-0.1-0.6-0.5-0.5-0.5-0.60.5-0.6-0.40.7
Locomotion distance, session 20.30.41.2-1.1-1.0-0.4-0.10.00.10.3-0.70.60.7-0.5
Locomotion velocity, session 30.20.20.4-0.2-0.20.60.40.50.50.5-0.70.40.7-0.5
Locomotion distance, session 31.51.63.1-0.5-0.51.00.91.21.21.3-1.71.51.8-1.6
Stereotopy head waving bouts, day 30.50.50.90.0-0.0-0.7-0.6-0.7-0.7-0.70.9-1.0-0.91.0
Stereotopy head waving duration, day 30.80.91.80.70.6-0.5-0.5-0.7-0.7-0.81.3-1.3-1.31.3
Locomotion velocity, session 70.60.61.70.40.30.70.50.60.60.7-0.91.20.9-1.3
Locomotion distance, session 70.20.31.0-0.1-0.10.50.20.40.30.4-0.70.90.7-1.0
Stereotopy head waving bouts, day 70.60.71.5-1.2-1.2-1.1-0.9-0.9-0.8-0.60.4-0.4-0.40.3
Stereotopy head waving duration, day 70.20.20.5-0.7-0.7-0.6-0.5-0.5-0.4-0.30.3-0.3-0.20.2
Locomotion velocity, session 80.10.20.30.30.30.20.40.40.40.4-0.30.50.3-0.5
Locomotion distance, session 81.01.52.00.70.81.11.21.31.31.4-1.31.41.3-1.4
Degree of sensitization distance1.01.11.90.30.2-0.7-0.9-1.1-1.1-1.21.4-1.2-1.41.1
Degree of sensitization stereotypy0.50.51.5-1.2-1.2-1.0-0.8-0.7-0.6-0.40.2-0.2-0.10.0
Conditioned locomotion2.12.42.9-1.3-1.4-1.5-1.7-1.7-1.7-1.71.5-1.4-1.51.5
Cocaine response after cond. corrected4.95.97.5-2.4-2.5-2.7-2.7-2.7-2.6-2.62.1-2.0-2.02.1
Cocaine response after cond. not corrected1.61.93.3-1.8-1.8-1.6-1.6-1.4-1.4-1.40.9-0.9-0.81.0
Cocaine response before conditioning6.88.110.02.22.32.93.13.23.13.1-2.92.82.8-2.8
Saline control response2.12.84.4-0.00.01.51.41.71.71.8-2.12.12.1-2.0
Bone: connectivity density0.40.71.00.80.81.00.80.80.80.8-0.90.80.8-0.7
Bone: cortical apparent density0.30.50.9-0.5-0.50.20.40.60.60.7-0.90.81.0-0.8
Bone: cortical area0.81.33.11.81.81.41.31.11.11.0-0.50.50.4-0.4
Bone: cortical porosity0.00.00.1-0.1-0.1-0.2-0.2-0.2-0.2-0.30.3-0.3-0.30.3
Bone: cortical porosity0.20.20.30.40.40.40.50.50.50.5-0.40.30.4-0.4
Bone: cortical thickness0.10.10.30.50.50.40.30.30.30.10.2-0.1-0.20.2
Bone: cortical thickness0.30.40.6-0.7-0.7-0.7-0.7-0.6-0.6-0.50.6-0.3-0.60.3
Bone: cortical tissue density0.40.51.1-0.6-0.50.20.40.60.60.7-1.00.91.0-0.9
Condit. Reinf. active minus inactive responses3.13.55.00.40.51.51.92.22.22.1-2.22.02.2-2.0
Condit. Reinf. active-inactive response ratio4.54.97.01.81.92.32.62.62.62.4-2.11.92.1-1.9
Condit. Reinf. active responses2.22.85.0-0.2-0.11.01.41.81.71.8-2.22.02.2-2.0
Condit. Reinf. inactive responses0.40.51.6-1.3-1.3-0.6-0.5-0.3-0.3-0.0-0.60.60.7-0.7
Incentive salience index mean3.03.75.70.20.31.61.92.22.22.2-2.42.12.4-2.1
Condit. Reinf. lever presses1.21.62.70.00.11.11.21.51.41.4-1.61.41.6-1.4
Condit. Reinf. active minus inactive responses3.34.36.11.01.02.12.02.22.22.2-2.42.52.3-2.4
Condit. Reinf. active-inactive response ratio4.45.16.71.51.52.62.32.52.52.4-2.42.32.3-2.1
Condit. Reinf. active responses3.04.26.51.11.11.81.92.12.12.2-2.22.62.2-2.5
Condit. Reinf. inactive responses0.40.51.20.60.50.30.60.60.60.7-0.61.00.6-1.1
Condit. Reinf. lever presses3.24.45.71.81.81.82.22.22.22.2-2.12.32.0-2.4
Condit. Reinf. lever reinforcers received3.14.36.61.11.21.92.02.12.12.2-2.32.62.3-2.5
Conditioned reinforcement - actives0.61.11.61.01.00.81.21.31.21.2-0.70.90.7-1.2
Conditioned reinforcement - inactives0.60.81.01.01.00.81.00.90.90.9-0.90.90.8-1.0
Conditioned locomotion1.01.22.11.11.01.01.11.21.11.0-0.91.30.9-1.4
Patch foraging indifference point 0 sec0.00.10.20.10.10.50.10.20.20.3-0.20.20.2-0.2
Patch foraging indifference point AUC1.21.77.5-2.7-2.7-0.6-0.7-0.2-0.20.1-0.90.81.1-0.7
Delay disc. indifference point, 0s delay0.60.71.41.21.21.11.00.90.90.9-0.60.30.5-0.1
Delay disc. indifference point, 16s delay0.00.00.2-0.1-0.1-0.00.10.10.10.0-0.20.30.3-0.5
Delay disc. indifference point, 2s delay0.50.61.71.31.20.90.80.70.70.6-0.40.10.4-0.0
Delay disc. indifference point, 24s delay0.50.61.0-0.7-0.7-0.9-0.9-0.9-0.9-1.00.6-0.3-0.50.3
Delay disc. indifference point, 4s delay1.41.53.00.20.20.81.01.11.11.2-1.71.51.7-1.4
Delay disc. indifference point, 8s delay0.91.11.60.70.61.10.91.01.00.8-1.21.21.3-1.2
Indifference point function ln k1.22.17.72.82.71.51.41.21.10.80.00.0-0.2-0.1
Indifference point function log k1.22.17.72.82.71.51.41.21.10.80.00.0-0.2-0.1
Patch foraging total patch changes 0 sec0.00.10.40.20.20.70.20.30.30.3-0.30.20.2-0.2
Patch foraging total patch changes 12 sec1.01.32.9-0.9-0.90.70.50.80.81.1-1.61.41.7-1.4
Patch foraging total patch changes 18 sec0.30.41.2-1.1-1.1-0.2-0.20.00.00.2-0.70.50.8-0.5
Patch foraging total patch changes 24 sec0.71.31.90.80.81.41.11.21.21.3-1.21.11.2-1.1
Patch foraging total patch changes 6 sec0.81.22.6-0.7-0.71.00.60.90.91.1-1.51.31.6-1.4
Patch foraging time to switch 0 sec0.10.20.60.80.8-0.2-0.0-0.3-0.3-0.20.4-0.3-0.50.2
Patch foraging water rate 0 sec0.20.50.80.20.20.90.70.80.80.8-0.90.80.8-0.7
Patch foraging water rate 12 sec0.81.63.41.81.81.51.41.31.31.1-0.80.60.6-0.7
Patch foraging water rate 18 sec1.52.34.02.02.01.91.71.71.61.4-1.00.80.9-0.8
Patch foraging water rate 24 sec1.62.23.51.61.61.71.81.91.81.5-1.11.11.0-1.0
Patch foraging water rate 6 sec0.30.40.90.70.70.90.70.80.70.6-0.50.40.4-0.3
Seeking ratio, delayed vs. immediate footshock3.74.56.21.41.52.52.22.32.22.2-2.22.32.1-2.2
Distance traveled before self-admin0.20.30.70.10.10.30.50.40.50.8-0.80.30.9-0.4
Distance traveled after self-admin2.43.04.11.61.61.62.02.02.02.0-1.71.31.6-1.3
Extensor digitorum longus weight0.00.00.1-0.2-0.20.30.00.10.0-0.0-0.0-0.3-0.00.3
Bone: elastic displacement0.50.51.3-1.1-1.2-0.9-0.8-0.7-0.7-0.60.3-0.5-0.30.5
Bone: elastic work0.10.10.30.50.40.30.20.20.20.20.1-0.3-0.10.3
Bone: endosteal estimation0.10.20.80.90.80.40.1-0.1-0.1-0.20.5-0.4-0.50.4
Bone: endosteal perimeter0.81.62.51.61.61.41.41.31.31.3-1.11.11.0-0.9
Epididymis fat weight1.24.310.33.23.22.72.32.12.01.7-0.90.70.8-0.9
Delta time in closed arm before/after self-admin0.50.40.6-0.6-0.7-0.6-0.8-0.8-0.8-0.80.6-0.4-0.70.5
Delta time in open arm before/after self-admin0.90.91.6-0.8-0.7-0.9-0.8-0.8-0.8-0.91.1-1.3-1.01.2
Diff in mean of infusions in LGA sessions0.30.41.00.1-0.1-0.20.10.20.20.3-0.91.01.0-1.0
Delay discount exponential model param0.60.71.3-0.3-0.3-0.6-0.7-0.8-0.8-0.71.1-1.1-1.11.0
Extinction: sum of active levers before priming0.10.10.3-0.4-0.4-0.20.10.20.20.1-0.40.40.6-0.5
Active lever presses in extinction session 61.31.31.71.21.30.71.21.01.11.0-1.31.01.3-1.1
Bone: final force0.71.12.11.41.41.31.11.11.11.0-0.70.50.6-0.4
Bone: final moment0.60.91.81.41.31.31.11.11.00.9-0.60.40.5-0.3
Food consumed during 24 hour testing period1.01.42.21.41.51.41.41.31.31.3-0.70.70.6-0.6
Glucose1.93.03.71.61.61.91.91.91.91.8-1.81.61.7-1.5
Heart weight2.43.66.82.62.62.22.22.12.11.9-1.21.01.2-0.8
Delay discount hyperbolic model param0.50.51.0-0.4-0.3-0.6-0.6-0.7-0.7-0.61.0-0.9-1.00.8
Intermittent access intake day 1-15 change0.10.10.2-0.3-0.20.10.30.40.40.4-0.40.30.4-0.3
Intermittent access intake escalation0.10.10.2-0.3-0.30.10.30.40.40.4-0.40.30.5-0.4
Intermittent access intake escalation 20.40.40.60.40.50.60.70.70.70.6-0.80.70.8-0.8
Intermitt. access day 1 inactive lever presses0.10.40.90.30.30.00.70.70.70.6-0.90.80.9-0.7
Intermitt. access day 15 inactive lever presses0.00.10.30.20.3-0.40.30.20.20.2-0.5-0.00.50.0
Intermitt. access escalation Index0.40.51.7-1.3-1.2-0.6-0.7-0.6-0.5-0.40.3-0.7-0.30.6
Intermittent access day 1 total infusions0.10.10.10.40.4-0.20.20.20.20.30.4-0.3-0.40.0
Intermittent access day 15 total infusions0.10.20.5-0.1-0.0-0.20.50.50.50.7-0.20.40.2-0.6
Intermittent access terminal intake (last 3 days)0.10.20.4-0.1-0.1-0.30.40.50.50.6-0.20.30.3-0.6
Intermittent access total infusions0.10.10.20.10.2-0.50.30.30.30.40.3-0.1-0.3-0.1
Intermittent access day 1 locomotion0.00.10.2-0.0-0.0-0.3-0.1-0.1-0.2-0.20.4-0.4-0.40.2
Intermittent access day 15 total locomotion0.10.10.6-0.1-0.2-0.8-0.2-0.1-0.2-0.30.2-0.3-0.20.1
Intermittent access total locomotion0.10.20.5-0.3-0.4-0.7-0.4-0.4-0.4-0.40.4-0.2-0.30.1
Intermittent access standard deviation0.30.60.90.30.40.40.80.80.81.0-0.91.00.9-0.9
Left kidney weight1.67.714.33.83.73.43.12.92.92.6-1.81.61.7-1.6
Right kidney weight2.913.322.44.74.74.14.23.93.93.6-2.62.42.5-2.4
Cocaine induced anxiety0.40.62.21.51.40.30.60.40.40.4-0.60.40.6-0.5
Post-drug Anxiety1.51.62.61.61.61.41.31.21.21.1-1.11.01.1-1.1
Baseline Anxiety0.20.31.10.20.21.10.60.80.70.60.00.1-0.1-0.0
Tail length2.610.114.53.83.83.33.53.33.33.2-2.72.72.5-2.6
Length with tail2.812.118.04.24.24.03.93.73.73.4-2.72.62.5-2.6
Length without tail0.82.64.92.22.22.21.81.81.71.5-0.90.60.8-0.7
Times rat made contact with spout0.80.91.8-0.0-0.11.10.81.00.91.1-1.01.20.9-1.3
Lifetime Intake0.40.51.2-0.4-0.4-1.1-0.4-0.3-0.4-0.31.1-0.9-1.00.7
Liver weight, left4.06.613.93.73.72.83.02.62.62.4-1.51.61.4-1.6
Liver weight, right1.11.96.12.52.41.51.61.41.31.0-0.30.20.2-0.1
Locomotor activity0.30.50.90.0-0.0-0.6-0.8-0.9-0.9-0.90.8-0.7-0.90.6
Locomotor testing distance0.30.62.71.61.60.70.60.40.40.3-0.20.30.1-0.4
Locomotor testing rearing0.20.41.01.00.90.60.40.30.30.4-0.60.70.6-0.9
Locomotion in novel chamber2.53.24.72.12.21.31.91.71.82.0-1.51.81.5-1.7
Locomotion in novel chamber post-restriction0.10.20.9-1.0-1.0-0.7-0.4-0.2-0.2-0.1-0.0-0.10.0-0.0
Fecal boli incidents, locomotor time 12.94.25.4-1.6-1.7-2.3-2.1-2.2-2.2-2.11.9-2.2-1.92.2
Change in fecal boli incidents, locomotor task3.53.54.71.51.52.02.02.22.12.1-1.71.81.7-1.8
Time >=10cm from walls, locomotor time 10.70.81.2-0.8-0.8-0.9-1.0-1.0-1.1-1.10.9-0.6-0.80.5
Bouts of movement, locomotor time 10.60.71.9-1.4-1.4-0.9-1.0-0.9-0.9-0.80.1-0.2-0.00.1
Total resting periods, locomotor time 11.11.22.9-1.7-1.7-1.4-1.3-1.2-1.2-1.00.3-0.4-0.20.3
Rest time, locomotor task time 12.12.64.2-2.0-2.0-2.0-1.8-1.7-1.6-1.41.3-1.2-1.21.1
Distance moved, locomotor task time 11.62.43.11.41.41.71.71.81.71.6-1.41.41.4-1.4
Vertical activity count, locomotor time 10.61.42.81.71.61.41.31.31.21.0-0.60.80.5-0.7
Time >=10cm from walls, locomotor time 22.43.54.42.02.02.12.02.02.01.8-1.61.71.5-1.7
Bouts of movement, locomotor time 20.40.61.20.40.40.40.60.60.60.6-1.11.01.1-1.0
Total resting periods, locomotor time 20.20.41.0-0.1-0.10.20.40.40.40.5-1.00.91.0-0.8
Rest time, locomotor task time 25.06.39.5-3.0-3.1-3.0-2.8-2.6-2.6-2.52.0-1.9-1.91.8
Distance moved, locomotor task time 25.66.78.32.12.12.52.82.92.92.8-2.62.62.5-2.6
Vertical activity count, locomotor time 25.47.49.73.13.13.03.02.92.92.7-2.22.42.1-2.3
Light reinforcement 10.41.11.60.40.31.21.01.31.21.1-1.01.10.9-1.3
Light reinforcement 20.71.11.9-1.3-1.4-1.2-1.2-1.0-1.0-1.00.9-0.8-1.00.9
Bone: marrow area0.10.20.70.90.80.30.1-0.1-0.1-0.20.5-0.4-0.50.5
Bone: maximum diameter0.30.61.71.31.30.80.80.70.70.6-0.20.40.1-0.2
Bone: maximum force1.11.94.42.12.11.71.51.41.41.2-0.70.50.6-0.4
Bone: maximum moment0.91.63.81.91.91.61.41.31.31.1-0.60.40.5-0.3
Mean time between licks in bursts0.00.10.6-0.3-0.3-0.8-0.2-0.2-0.20.0-0.10.10.1-0.2
Mean num. licks in bursts0.20.31.2-1.1-1.10.1-0.20.10.00.1-0.20.40.2-0.3
Cd content in liver1.82.03.40.30.31.01.31.51.51.6-1.71.81.7-1.9
Co content in liver0.60.72.4-1.6-1.5-0.6-0.6-0.3-0.3-0.1-0.50.60.6-0.7
Cu content in liver1.01.11.6-1.2-1.2-1.2-1.2-1.3-1.2-1.10.7-0.7-0.70.8
Fe content in liver0.50.61.2-0.5-0.4-0.9-0.6-0.7-0.7-0.70.8-0.9-0.81.1
K content in liver0.40.30.8-0.2-0.20.60.20.30.30.4-0.90.90.9-0.8
Mg content in liver0.20.30.5-0.00.00.70.40.40.40.5-0.60.70.6-0.6
Mn content in liver0.40.50.8-0.9-0.9-0.5-0.8-0.7-0.7-0.80.5-0.5-0.50.6
Na content in liver1.51.62.00.70.71.21.31.41.41.4-1.31.41.3-1.3
Rb content in liver0.81.03.0-1.7-1.7-1.2-1.0-0.9-0.8-0.70.3-0.3-0.20.3
Se content in liver1.01.21.8-0.5-0.5-1.0-1.0-1.2-1.2-1.31.2-1.2-1.21.3
Sr content in liver0.10.10.30.00.10.20.30.40.40.4-0.30.40.4-0.5
Zn content in liver0.10.20.2-0.3-0.3-0.2-0.5-0.5-0.5-0.50.4-0.3-0.40.4
Bone: minimum diameter1.42.65.02.22.21.91.81.71.71.5-1.01.00.9-0.8
Time in familiar zone, hab. session 10.60.60.7-0.8-0.8-0.7-0.8-0.8-0.8-0.80.7-0.8-0.70.7
Time in novel zone, hab. session 11.01.01.31.00.90.91.11.21.11.0-0.90.90.9-0.8
Total zone transitions, hab. session 11.21.72.50.60.71.31.31.41.41.4-1.61.31.6-1.4
Total locomotion distance, hab. session 10.00.00.0-0.1-0.1-0.20.10.10.10.1-0.1-0.00.1-0.1
Locomotion velocity, hab. session 10.00.00.1-0.2-0.1-0.30.00.00.00.10.1-0.1-0.00.0
Time in familiar zone, hab. session 20.00.00.10.10.10.4-0.0-0.1-0.1-0.10.1-0.1-0.10.1
Time in novel zone, hab. session 20.10.10.10.40.30.00.30.30.30.30.0-0.1-0.10.1
Total zone transitions, hab. session 20.10.20.3-0.4-0.30.00.30.40.40.4-0.50.40.5-0.4
Total locomotion distance, hab. session 21.01.32.0-1.0-0.9-1.4-1.0-1.1-1.0-0.91.3-1.3-1.21.3
Locomotion velocity, hab. session 20.91.12.0-1.1-1.0-1.4-1.0-1.0-1.0-0.91.1-1.1-1.01.1
Novel to familiar place preference ratio0.40.41.31.11.10.20.70.60.60.6-0.20.40.2-0.4
Novelty place preference0.40.51.31.21.10.20.80.70.70.7-0.30.50.3-0.5
Time in novel zone, NPP test0.40.41.21.11.00.20.70.70.70.7-0.20.50.2-0.4
Total zone transitions, NPP test0.71.03.6-1.9-1.8-1.1-0.9-0.8-0.7-0.60.4-0.6-0.40.6
Total locomotion distance, NPP test1.11.52.3-1.4-1.3-1.5-1.1-1.1-1.1-1.01.1-1.2-1.01.2
Locomotion velocity, NPP test1.11.62.5-1.2-1.2-1.6-1.2-1.3-1.2-1.21.1-1.3-1.11.3
Intraocular pressure2.02.84.5-1.1-1.2-2.1-1.7-1.8-1.8-1.61.7-1.8-1.61.8
Delta distance traveled before/after self-admin0.60.71.10.70.70.60.91.11.01.0-0.70.80.7-0.7
Delta ambulatory time before/after self-admin0.80.91.40.90.90.91.11.21.11.0-0.90.90.8-0.9
Parametrial fat weight0.10.20.50.40.3-0.7-0.3-0.5-0.5-0.30.5-0.4-0.50.7
Pavlov. Cond. lever latency0.10.10.30.20.1-0.3-0.4-0.5-0.5-0.50.5-0.2-0.50.2
Pavlov. Cond. magazine entry latency0.91.11.70.40.40.81.11.11.21.2-1.31.11.3-1.1
Pavlov. Cond. change in total contacts1.21.22.4-0.5-0.40.50.91.21.11.2-1.51.31.5-1.3
Pavlov. Cond. index score0.50.61.2-0.2-0.10.50.70.90.91.0-1.10.81.1-0.8
Pavlov. Cond. latency score0.40.50.9-0.2-0.20.40.60.80.80.9-0.90.71.0-0.7
Pavlov. Cond. lever contacts0.40.50.8-0.1-0.00.50.70.90.90.8-0.90.50.9-0.5
Pavlov. Cond. magazine entry number2.02.54.2-0.3-0.3-1.2-1.5-1.7-1.7-1.82.0-1.8-2.11.8
Pavlov. Cond. intertrial magazine entries1.11.32.20.50.51.01.11.21.21.2-1.31.51.3-1.3
Pavlov. Cond. lever-magazine prob. diff.0.60.71.4-0.3-0.30.50.70.90.91.0-1.10.81.2-0.8
Pavlov. Cond. response bias0.91.12.1-0.1-0.10.71.01.21.21.2-1.41.11.5-1.1
Pavlov. Cond. lever latency4.25.77.7-1.7-1.7-2.0-2.5-2.6-2.6-2.62.5-2.7-2.52.8
Pavlov. Cond. magazine entry latency0.70.81.01.01.00.81.00.90.90.9-0.90.80.8-0.8
Pavlov. Cond. change in total contacts1.82.94.10.80.81.51.71.81.81.9-1.92.01.9-2.0
Pavlov. Cond. index score3.54.75.51.81.82.02.32.32.32.3-2.22.32.2-2.3
Pavlov. Cond. latency score3.85.05.91.81.82.02.32.42.42.4-2.32.42.3-2.4
Pavlov. Cond. lever contacts4.25.87.21.91.92.12.52.62.62.6-2.42.62.4-2.7
Pavlov. Cond. magazine entry number1.62.02.2-1.4-1.5-1.4-1.5-1.4-1.4-1.41.4-1.4-1.41.4
Pavlov. Cond. intertrial magazine entries0.20.31.31.11.10.60.40.30.30.10.1-0.2-0.20.2
Pavlov. Cond. lever-magazine prob. diff.3.14.14.71.71.71.92.12.12.12.2-2.02.12.0-2.1
Pavlov. Cond. response bias3.34.55.31.91.91.92.22.22.22.3-2.12.32.0-2.3
Time in closed arm before self-admin2.53.24.11.51.51.82.02.02.01.9-1.91.61.7-1.6
Time in closed arm after self-admin1.11.21.81.31.31.31.21.11.11.0-1.00.80.9-0.8
Time in open arm before self-admin0.10.10.3-0.6-0.5-0.3-0.2-0.3-0.2-0.2-0.00.10.1-0.1
Time in open arm after self-admin0.70.81.6-1.3-1.2-1.0-0.8-0.7-0.7-0.70.7-0.9-0.60.8
Bone: periosteal estimation0.30.62.21.51.41.00.60.50.50.30.2-0.1-0.30.2
Bone: periosteal perimeter0.71.22.91.71.71.41.31.11.11.0-0.60.60.6-0.4
Bone: post-yield work0.20.30.60.80.80.60.60.60.60.5-0.0-0.00.0-0.0
Progressive ratio test 1 active lever presses0.10.10.3-0.1-0.1-0.3-0.1-0.0-0.0-0.00.4-0.5-0.40.4
Progressive ratio test 1 breakpoint0.10.10.2-0.1-0.1-0.3-0.1-0.0-0.0-0.00.4-0.5-0.40.4
Progressive ratio test 1 inactive lever presses0.20.30.6-0.8-0.8-0.5-0.5-0.3-0.4-0.30.6-0.6-0.60.6
Progressive ratio test 2 active lever presses0.30.30.50.70.7-0.00.60.60.60.7-0.20.40.3-0.7
Progressive ratio test 2 breakpoint0.30.40.60.70.70.10.70.60.60.8-0.30.50.4-0.8
Progressive ratio test 2 inactive lever presses0.20.41.71.31.30.10.60.40.40.50.0-0.1-0.1-0.1
Incentive Sensitization - Responses0.00.10.40.20.1-0.60.10.10.10.4-0.10.10.1-0.3
Incentive Sensitization - Breakpoint0.00.10.40.20.1-0.60.10.10.10.30.00.10.0-0.2
Sum of active levers in priming session hrs 5-60.80.71.1-0.3-0.3-1.0-0.7-0.8-0.8-0.81.0-1.0-1.01.0
Progressive ratio0.81.32.40.10.0-1.1-0.9-1.1-1.1-1.11.4-1.6-1.41.5
Food seeking constrained by brief footshock0.50.71.3-0.4-0.4-0.6-0.8-0.8-0.8-0.80.8-1.2-0.91.1
Seeking ratio, punishment vs. effort0.20.30.5-0.7-0.70.30.20.30.30.4-0.60.60.6-0.6
Retroperitoneal fat weight9.339.561.87.87.96.97.16.66.66.2-5.04.64.7-4.4
Reaction time number correct0.91.72.51.21.31.61.41.41.41.3-1.11.21.0-1.2
Reaction time mean minus median0.00.00.1-0.1-0.10.00.20.30.20.30.00.10.1-0.1
Reaction time mean minus median AUC0.20.61.20.50.50.60.90.91.01.1-0.70.80.8-0.8
Reaction time num false alarms0.20.30.8-0.4-0.50.10.00.10.20.2-0.90.90.9-0.8
Reaction time num false alarms AUC0.20.30.6-0.8-0.8-0.1-0.3-0.1-0.1-0.1-0.60.60.6-0.5
Reaction time trials correct on left0.91.72.51.21.31.61.41.41.41.3-1.11.21.0-1.2
Reaction time trials on left0.81.62.31.11.21.51.41.41.41.3-1.11.21.0-1.2
Reaction time mean0.10.10.20.50.50.40.50.50.50.4-0.00.00.10.0
Reaction time mean AUC0.20.30.50.70.70.60.70.70.70.6-0.20.30.3-0.2
Median of all reaction times0.10.20.40.70.70.50.50.40.40.30.00.0-0.00.0
Reaction time omissions0.20.31.0-1.0-1.0-0.6-0.6-0.5-0.5-0.50.3-0.1-0.20.1
Reaction time false alarm rate0.40.61.6-1.3-1.3-0.8-0.9-0.8-0.7-0.7-0.0-0.00.10.1
Reaction time premature initiation rate0.20.31.2-1.1-1.10.1-0.10.20.20.3-0.50.50.5-0.4
Reaction time premature initiations0.30.50.9-0.6-0.60.70.40.70.70.7-0.90.90.8-0.8
Std. dev. reaction times0.10.20.40.40.50.50.60.60.60.5-0.10.20.2-0.1
Reaction time trials completed0.81.62.31.11.21.51.41.41.41.3-1.11.21.0-1.2
Reaction time trials AUC0.91.82.51.11.11.61.41.51.41.4-1.21.31.1-1.3
Run reversals in cocaine runway, females1.81.82.21.41.41.51.51.41.41.5-1.41.01.3-1.1
Run reversals in cocaine runway, males1.01.02.6-1.3-1.4-1.6-1.2-1.0-1.0-0.90.5-0.1-0.40.1
Latency to leave start box in cocaine runway0.20.21.0-1.0-1.0-0.5-0.3-0.1-0.1-0.0-0.1-0.20.10.2
Latency to leave start box in cocaine runway, F0.30.30.7-0.8-0.8-0.4-0.4-0.3-0.3-0.30.5-0.7-0.60.7
Latency to leave start box in cocaine runway, M0.70.71.7-0.2-0.30.20.50.60.60.7-1.31.01.3-1.0
Std. dev. time between licks in bursts1.92.63.31.51.51.31.81.81.81.8-1.51.51.5-1.6
Total sessions with >9 infusions1.72.13.6-1.1-1.1-1.5-1.3-1.1-1.2-1.21.9-1.7-1.81.7
Short access day 1 total inactive lever presses0.60.81.40.20.3-0.7-0.6-0.8-0.9-0.81.2-1.1-1.21.1
Short access day 10 total inactive lever presses0.71.63.20.80.90.71.21.11.11.0-1.81.61.8-1.5
Short access day 1 total infusions2.33.14.8-1.2-1.2-1.7-1.6-1.6-1.6-1.72.2-2.0-2.12.0
Short access day 10 total infusions1.31.74.1-1.3-1.3-2.0-1.1-0.9-1.0-1.01.5-1.3-1.41.1
Short access total infusions2.63.34.9-1.4-1.5-2.1-1.7-1.5-1.6-1.72.2-2.1-2.11.9
Short access day 1 locomotion0.40.51.3-0.4-0.5-1.1-0.7-0.6-0.6-0.81.0-0.6-0.90.6
Short access day 10 total locomotion0.20.40.9-0.9-0.9-0.6-0.7-0.6-0.6-0.60.30.0-0.30.1
Short access total locomotion0.10.10.3-0.5-0.5-0.4-0.2-0.1-0.1-0.10.10.2-0.1-0.1
One hour access (0.3 mA shock)0.60.71.50.20.20.30.81.01.00.9-0.91.01.0-1.2
Compulsive drug intake0.60.71.9-1.4-1.3-0.6-1.0-0.9-0.9-0.70.1-0.2-0.10.3
One hour access (shock baseline)0.71.12.01.11.00.51.31.41.41.2-0.80.80.8-1.1
Social response proportion1.82.03.2-1.7-1.8-1.5-1.5-1.2-1.3-1.51.3-1.1-1.41.1
Social responses0.40.61.1-0.3-0.20.50.70.90.80.7-0.81.10.8-1.1
Social time3.85.212.0-3.5-3.4-2.8-2.5-2.1-2.1-2.01.4-1.2-1.41.1
Soleus weight0.20.50.9-0.3-0.3-0.7-0.6-0.7-0.7-0.70.9-1.0-0.90.9
Bone: stiffness0.81.44.02.01.91.31.31.11.11.0-0.40.40.4-0.3
Tibialis anterior weight0.82.73.3-1.8-1.8-1.5-1.8-1.7-1.7-1.71.5-1.6-1.51.6
Time to tail flick, vehicle, before self-admin0.40.40.91.00.90.50.50.40.50.7-0.60.50.6-0.7
Time to tail flick, vehicle, after self-admin1.31.73.31.11.21.81.31.31.31.1-1.31.31.2-1.2
Time to tail flick, test, before self-admin0.70.71.50.10.10.40.70.70.80.9-1.21.21.2-1.0
Time to tail flick, test, after self-admin0.00.00.2-0.1-0.00.50.10.10.1-0.1-0.0-0.1-0.00.2
Delta time to tail flick, vehicle, before/after SA1.21.13.71.01.11.91.21.11.10.8-0.70.70.7-0.4
Delta time to tail flick, test, before/after SA0.80.81.6-0.3-0.3-0.4-0.8-0.8-0.9-1.11.1-1.2-1.31.1
Tibia length0.10.31.0-0.9-1.0-0.6-0.6-0.5-0.5-0.40.3-0.3-0.30.2
Ambulatory time before self-admin0.10.20.50.20.30.30.50.40.50.7-0.60.20.7-0.2
Ambulatory time after self-admin2.42.94.11.41.51.42.02.02.02.0-1.71.31.7-1.3
Bone: tissue strength1.61.62.9-0.7-0.7-0.9-1.2-1.1-1.2-1.41.5-1.7-1.51.6
Total heroin consumption0.60.71.3-0.5-0.6-0.9-0.9-0.9-0.9-1.10.8-0.9-0.70.9
Bone: trabecular number0.91.52.51.31.21.61.31.21.21.2-1.21.11.1-1.1
Bone: trabecular spacing0.20.30.5-0.5-0.5-0.7-0.6-0.6-0.6-0.60.5-0.5-0.50.4
Bone: trabecular thickness0.91.11.51.21.21.21.11.21.21.0-0.90.90.8-0.8
Bone: trabecular tissue density0.10.20.3-0.3-0.4-0.2-0.5-0.5-0.5-0.50.5-0.6-0.50.5
Water consumed over 24 hours0.10.20.30.50.50.60.50.50.40.50.10.1-0.1-0.1
Number of responses in last shaping day0.70.71.50.50.5-0.21.11.21.21.0-0.70.60.8-0.6