Hub : Genes

Slc35f6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	NM_001017451.1	0.03	0.03	3.0e-03	0.02	0.01	0.01	0.01	5.7e-03	9.8e-03	9.6e-03	9.8e-03
2	Liver	isoform ratio	XM_039111916.1	0.03	0.03	2.4e-03	0.02	0.01	0.01	0.01	5.8e-03	8.7e-03	1.2e-02	1.2e-02
3	Brain	gene expression	Slc35f6	0.04	0.03	1.1e-04	0.03	0.04	0.01	0.03	1.9e-03	2.8e-04	2.5e-02	6.9e-04
4	PL	gene expression	Slc35f6	0.02	0.02	2.4e-03	0.01	0.01	0	0	5.7e-02	2.4e-02	3.4e-01	8.3e-02
5	BLA	gene expression	Slc35f6	0.08	0.06	6.6e-04	0.03	0.04	0.04	0.03	6.9e-03	2.4e-03	4.3e-03	9.6e-03
6	LHb	gene expression	Slc35f6	0.15	0.13	3.9e-03	0.07	0.04	0.02	0.04	8.7e-03	4.8e-02	1.2e-01	3.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	3.5	5.8	6.7	2.4	-2.4	2.5	2.6	2.4	-2.1
Area under the delay curve	0.0	0.0	0.1	0.0	-0.0	-0.2	-0.2	-0.2	-0.2
BMI with tail	2.2	7.2	8.6	-2.9	2.9	-2.4	-2.2	-2.7	2.9
BMI without tail	0.4	0.7	1.0	-1.0	1.0	-0.8	-0.7	-0.9	0.7
Body weight	2.2	9.2	9.8	-2.9	2.9	-3.1	-3.0	-3.1	3.1
Weight adjusted by age	0.3	0.4	1.0	-1.0	1.0	-0.3	-0.2	-0.5	0.3
Bone surface	0.8	1.4	2.2	1.0	-1.0	1.4	1.5	1.2	-0.8
Bone volume	1.7	2.9	3.4	1.7	-1.7	1.8	1.8	1.7	-1.4
Breakpoint value in progressive ratio session	1.1	1.2	1.4	1.1	-1.1	1.1	1.2	1.1	-1.0
Number of licking bursts	1.1	1.3	1.8	-1.3	1.3	-0.9	-0.8	-1.1	1.3
Context. condit. distance diff. score	0.1	0.2	0.3	0.6	-0.6	0.3	0.2	0.4	-0.2
Locomotion velocity, session 1	0.7	0.8	1.1	-1.1	1.1	-0.7	-0.6	-0.8	1.0
Locomotion distance, session 1	0.3	0.4	0.9	0.3	-0.3	0.9	0.9	0.7	-0.1
Locomotion velocity, session 2	0.1	0.1	0.2	-0.1	0.1	-0.4	-0.4	-0.3	0.3
Locomotion distance, session 2	0.1	0.2	0.5	-0.5	0.5	-0.2	-0.2	-0.3	0.7
Locomotion velocity, session 3	0.1	0.2	0.4	0.2	-0.2	0.6	0.7	0.4	-0.2
Locomotion distance, session 3	0.1	0.1	0.2	-0.1	0.1	0.3	0.4	0.1	0.5
Stereotopy head waving bouts, day 3	2.1	2.5	3.0	1.3	-1.3	1.7	1.7	1.7	-1.7
Stereotopy head waving duration, day 3	0.5	0.6	1.0	0.6	-0.6	0.8	0.8	0.8	-1.0
Locomotion velocity, session 7	0.1	0.1	0.3	-0.1	0.1	0.4	0.5	0.2	0.1
Locomotion distance, session 7	0.7	0.9	2.0	-1.1	1.1	-0.6	-0.5	-0.9	1.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	0.2	-0.0	-0.1	-0.0	-0.1
Stereotopy head waving duration, day 7	0.5	0.6	1.0	0.6	-0.6	0.8	0.8	0.8	-1.0
Locomotion velocity, session 8	0.5	0.6	0.8	0.8	-0.8	0.8	0.7	0.8	-0.9
Locomotion distance, session 8	0.2	0.3	0.4	0.5	-0.5	0.6	0.6	0.6	-0.3
Degree of sensitization distance	0.9	0.9	1.0	-0.9	0.9	-1.0	-1.0	-1.0	0.9
Degree of sensitization stereotypy	0.3	0.3	0.4	-0.6	0.6	-0.5	-0.5	-0.5	0.5
Conditioned locomotion	4.1	4.7	6.1	2.0	-2.0	2.2	2.2	2.2	-2.5
Cocaine response after cond. corrected	0.3	0.3	0.3	0.5	-0.5	0.6	0.6	0.5	-0.5
Cocaine response after cond. not corrected	0.9	1.0	1.2	0.9	-0.9	1.1	1.1	1.0	-1.1
Cocaine response before conditioning	2.1	2.6	3.2	1.5	-1.5	1.6	1.6	1.7	-1.8
Saline control response	1.3	1.7	2.3	1.5	-1.5	1.3	1.2	1.3	-0.8
Bone: connectivity density	2.5	3.9	5.1	2.0	-2.0	2.2	2.3	1.9	-1.4
Bone: cortical apparent density	0.1	0.1	0.1	0.3	-0.3	0.3	0.4	0.3	-0.4
Bone: cortical area	0.0	0.1	0.3	0.1	-0.1	-0.0	0.1	-0.2	0.5
Bone: cortical porosity	3.3	3.6	4.2	1.9	-1.9	1.8	1.8	1.9	-2.1
Bone: cortical porosity	2.7	2.9	3.5	1.8	-1.8	1.6	1.6	1.7	-1.9
Bone: cortical thickness	0.2	0.3	0.5	-0.3	0.3	-0.6	-0.6	-0.7	0.6
Bone: cortical thickness	0.6	0.7	1.0	0.9	-0.9	0.9	1.0	0.8	-0.7
Bone: cortical tissue density	0.0	0.1	0.1	0.2	-0.2	0.2	0.3	0.2	-0.2
Condit. Reinf. active minus inactive responses	1.7	1.9	2.1	-1.4	1.4	-1.3	-1.3	-1.4	1.4
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.5	-1.2	1.2	-1.2	-1.1	-1.2	1.2
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.1	-0.3	0.4
Condit. Reinf. inactive responses	0.9	1.1	1.4	0.9	-0.9	1.2	1.2	1.1	-0.8
Incentive salience index mean	0.2	0.2	0.3	-0.5	0.5	-0.3	-0.3	-0.4	0.6
Condit. Reinf. lever presses	0.4	0.6	0.6	0.8	-0.8	0.8	0.8	0.8	-0.6
Condit. Reinf. active minus inactive responses	1.8	2.3	3.7	1.0	-1.0	1.8	1.9	1.6	-1.5
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.1	0.7	-0.7	1.0	1.0	0.9	-1.1
Condit. Reinf. active responses	1.2	1.7	3.1	0.7	-0.7	1.6	1.7	1.4	-1.2
Condit. Reinf. inactive responses	0.4	0.5	1.1	0.3	-0.3	1.0	1.1	0.7	-0.4
Condit. Reinf. lever presses	1.1	1.6	2.2	0.8	-0.8	1.5	1.5	1.3	-1.3
Condit. Reinf. lever reinforcers received	1.1	1.5	2.8	0.7	-0.7	1.5	1.7	1.3	-1.1
Conditioned reinforcement - actives	4.7	4.7	6.3	2.5	-2.5	1.9	1.9	2.0	-2.1
Conditioned reinforcement - inactives	5.1	5.7	6.8	2.6	-2.6	2.3	2.3	2.4	-2.2
Conditioned locomotion	3.3	3.9	5.2	2.3	-2.3	1.8	1.7	1.9	-1.9
Patch foraging indifference point 0 sec	0.7	1.2	2.4	-1.0	1.0	-0.9	-0.9	-1.0	1.6
Patch foraging indifference point AUC	0.2	0.3	0.7	0.2	-0.2	0.7	0.9	0.4	-0.3
Delay disc. indifference point, 0s delay	1.8	2.0	3.2	-1.1	1.1	-1.7	-1.8	-1.5	1.0
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.3	0.3	-0.1	-0.1	-0.2	0.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	-0.3	0.3	-0.5	-0.6	-0.5	0.2
Delay disc. indifference point, 24s delay	2.1	2.1	2.5	1.5	-1.5	1.3	1.2	1.4	-1.6
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.4	-0.5	0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.3	-0.3	0.1	0.1	0.1	-0.5
Indifference point function ln k	0.9	1.2	1.7	1.3	-1.3	0.9	0.7	1.1	-1.2
Indifference point function log k	0.9	1.2	1.7	1.3	-1.3	0.9	0.7	1.1	-1.2
Patch foraging total patch changes 0 sec	0.7	1.1	2.5	-1.0	1.0	-0.9	-0.9	-0.9	1.6
Patch foraging total patch changes 12 sec	1.1	1.4	2.2	-1.1	1.1	-1.2	-1.2	-1.2	1.5
Patch foraging total patch changes 18 sec	0.8	1.0	2.0	-1.0	1.0	-0.7	-0.6	-0.9	1.4
Patch foraging total patch changes 24 sec	1.3	1.6	2.0	-1.3	1.3	-1.2	-1.1	-1.2	1.4
Patch foraging total patch changes 6 sec	1.3	2.0	2.8	-1.6	1.6	-1.1	-1.0	-1.4	1.7
Patch foraging time to switch 0 sec	0.3	0.4	0.7	-0.8	0.8	-0.4	-0.3	-0.5	0.7
Patch foraging water rate 0 sec	0.7	1.1	1.6	1.3	-1.3	0.9	0.8	1.0	-1.0
Patch foraging water rate 12 sec	0.2	0.3	0.8	-0.2	0.2	-0.8	-0.9	-0.6	0.4
Patch foraging water rate 18 sec	0.6	0.8	1.6	1.3	-1.3	0.4	0.2	0.8	-0.7
Patch foraging water rate 24 sec	0.3	0.4	1.1	-0.0	0.0	-0.9	-1.0	-0.7	0.6
Patch foraging water rate 6 sec	0.1	0.1	0.3	0.2	-0.2	-0.4	-0.6	-0.1	-0.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.0	-0.0	-0.0	0.0	-0.1	0.4
Distance traveled before self-admin	0.3	0.3	0.6	0.6	-0.6	0.3	0.2	0.3	-0.8
Distance traveled after self-admin	0.4	0.5	0.7	-0.4	0.4	-0.8	-0.9	-0.7	0.8
Extensor digitorum longus weight	2.8	11.0	13.9	3.3	-3.3	3.6	3.7	3.3	-2.7
Bone: elastic displacement	2.1	2.3	3.0	1.7	-1.7	1.3	1.3	1.4	-1.7
Bone: elastic work	0.8	1.0	1.3	1.0	-1.0	1.0	1.0	0.9	-1.1
Bone: endosteal estimation	0.1	0.2	0.4	0.2	-0.2	0.6	0.6	0.4	0.1
Bone: endosteal perimeter	0.0	0.0	0.1	-0.1	0.1	0.2	0.2	0.1	0.3
Epididymis fat weight	15.1	35.2	38.5	-5.8	5.8	-6.2	-6.2	-6.2	5.4
Delta time in closed arm before/after self-admin	0.4	0.4	0.7	-0.6	0.6	-0.5	-0.5	-0.6	0.9
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.5	-0.5	0.4	0.5	0.4	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	0.1	-0.1	0.3	0.4	0.3	-0.2
Delay discount exponential model param	0.0	0.0	0.2	-0.2	0.2	-0.1	-0.1	-0.0	0.4
Extinction: sum of active levers before priming	0.4	0.4	0.6	0.8	-0.8	0.6	0.6	0.7	-0.2
Active lever presses in extinction session 6	1.6	1.6	2.0	1.4	-1.4	1.2	1.2	1.2	-1.0
Bone: final force	0.0	0.0	0.1	0.2	-0.2	0.0	0.0	-0.1	0.2
Bone: final moment	0.0	0.0	0.0	0.2	-0.2	0.1	0.1	-0.1	0.2
Food consumed during 24 hour testing period	0.1	0.1	0.3	-0.6	0.6	-0.1	-0.0	-0.2	0.3
Glucose	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.6	-0.6	0.4
Heart weight	5.4	7.6	11.1	-2.2	2.2	-3.2	-3.3	-2.9	2.5
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.2	0.2	-0.0	-0.1	0.0	0.3
Intermittent access intake day 1-15 change	1.3	1.3	1.8	1.3	-1.3	1.0	0.9	1.2	-1.0
Intermittent access intake escalation	0.6	0.6	0.9	0.9	-0.9	0.7	0.6	0.8	-0.7
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.1	0.1	-0.3	-0.4	-0.3	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	0.5	-0.5	0.3	0.3	0.2	0.0
Intermitt. access day 15 inactive lever presses	2.8	3.0	5.6	1.2	-1.2	2.2	2.4	1.8	-1.4
Intermitt. access escalation Index	3.0	2.7	4.4	-2.1	2.1	-1.2	-1.1	-1.4	1.7
Intermittent access day 1 total infusions	4.8	5.5	6.1	2.3	-2.3	2.4	2.5	2.3	-2.2
Intermittent access day 15 total infusions	4.3	4.8	5.9	2.4	-2.4	2.1	2.1	2.2	-2.0
Intermittent access terminal intake (last 3 days)	3.7	4.1	4.6	2.1	-2.1	1.9	1.9	2.0	-2.0
Intermittent access total infusions	5.3	5.9	7.1	2.7	-2.7	2.2	2.2	2.3	-2.4
Intermittent access day 1 locomotion	2.4	2.6	2.7	1.6	-1.6	1.6	1.6	1.6	-1.4
Intermittent access day 15 total locomotion	0.7	0.8	0.9	1.0	-1.0	0.9	0.9	0.8	-0.7
Intermittent access total locomotion	1.0	1.2	1.7	1.3	-1.3	1.0	1.0	1.0	-0.8
Intermittent access standard deviation	0.9	1.0	1.9	1.4	-1.4	0.8	0.8	0.8	-0.2
Left kidney weight	0.5	1.3	2.8	1.7	-1.7	0.6	0.5	0.9	-0.8
Right kidney weight	0.3	0.8	1.8	0.1	-0.1	-1.2	-1.3	-0.9	0.9
Cocaine induced anxiety	0.1	0.1	0.2	0.2	-0.2	0.4	0.5	0.3	-0.5
Post-drug Anxiety	1.2	1.4	1.7	-1.0	1.0	-1.3	-1.3	-1.3	1.1
Baseline Anxiety	1.6	1.7	2.0	-1.2	1.2	-1.4	-1.4	-1.4	1.3
Tail length	0.1	0.3	0.6	0.7	-0.7	0.3	0.2	0.5	-0.8
Length with tail	0.3	1.1	2.2	-0.5	0.5	-1.3	-1.5	-1.0	0.9
Length without tail	0.3	0.7	1.3	-0.4	0.4	-0.9	-1.0	-0.7	1.1
Times rat made contact with spout	0.7	0.8	1.2	0.7	-0.7	1.1	1.1	0.9	-0.8
Lifetime Intake	6.3	7.1	8.2	2.9	-2.9	2.5	2.5	2.6	-2.6
Liver weight, left	1.2	1.9	2.3	-1.3	1.3	-1.5	-1.5	-1.4	1.2
Liver weight, right	7.2	12.0	14.3	-3.2	3.2	-3.7	-3.8	-3.5	3.5
Locomotor activity	0.7	1.1	1.9	-1.0	1.0	-0.9	-0.9	-1.0	1.4
Locomotor testing distance	0.3	0.5	1.0	-0.9	0.9	-0.3	-0.2	-0.5	1.0
Locomotor testing rearing	0.4	0.7	1.3	0.6	-0.6	1.1	1.1	1.0	-0.2
Locomotion in novel chamber	0.5	0.6	0.7	-0.7	0.7	-0.8	-0.8	-0.8	0.6
Locomotion in novel chamber post-restriction	3.2	3.8	4.6	-2.0	2.0	-1.9	-1.8	-1.9	2.1
Fecal boli incidents, locomotor time 1	2.2	2.5	3.7	1.9	-1.9	1.3	1.2	1.5	-1.3
Change in fecal boli incidents, locomotor task	3.9	3.7	4.4	-1.8	1.8	-2.1	-2.1	-2.0	1.8
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	0.6	-0.6	0.2	0.2	0.4	-0.6
Bouts of movement, locomotor time 1	0.2	0.2	0.7	-0.0	0.0	0.7	0.8	0.4	-0.1
Total resting periods, locomotor time 1	0.3	0.3	0.9	-0.1	0.1	0.8	1.0	0.5	-0.1
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.0	0.0	0.3	0.3	0.2	-0.2
Distance moved, locomotor task time 1	0.4	0.5	0.8	-0.6	0.6	-0.8	-0.9	-0.7	0.3
Vertical activity count, locomotor time 1	0.3	0.4	0.6	-0.5	0.5	-0.7	-0.8	-0.6	0.1
Time >=10cm from walls, locomotor time 2	1.3	1.4	1.8	1.3	-1.3	1.0	1.0	1.2	-1.3
Bouts of movement, locomotor time 2	0.6	0.7	1.0	-1.0	1.0	-0.7	-0.7	-0.8	0.8
Total resting periods, locomotor time 2	0.7	0.7	1.2	-1.1	1.1	-0.6	-0.5	-0.7	0.9
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.3	0.3	0.5	0.6	0.3	-0.1
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.0	-0.0	-0.3	-0.4	-0.1	-0.3
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.5	-0.5	0.1	0.0	0.3	-0.8
Light reinforcement 1	0.8	1.4	3.2	0.6	-0.6	1.6	1.8	1.3	-0.3
Light reinforcement 2	1.3	1.7	2.7	0.9	-0.9	1.6	1.7	1.4	-1.1
Bone: marrow area	0.1	0.2	0.4	0.2	-0.2	0.6	0.7	0.5	0.1
Bone: maximum diameter	0.1	0.1	0.3	0.1	-0.1	0.4	0.5	0.2	0.4
Bone: maximum force	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	-0.2	0.3
Bone: maximum moment	0.0	0.0	0.0	0.2	-0.2	0.0	0.0	-0.1	0.1
Mean time between licks in bursts	2.2	3.1	3.7	-1.8	1.8	-1.9	-1.9	-1.8	1.3
Mean num. licks in bursts	1.3	1.6	2.0	1.4	-1.4	1.1	1.0	1.2	-1.3
Cd content in liver	0.3	0.4	1.0	-0.6	0.6	-0.4	-0.3	-0.5	1.0
Co content in liver	5.1	6.0	7.1	2.2	-2.2	2.6	2.6	2.5	-2.7
Cu content in liver	0.0	0.1	0.1	0.3	-0.3	0.3	0.3	0.3	0.1
Fe content in liver	0.1	0.1	0.1	0.3	-0.3	0.3	0.3	0.3	0.2
K content in liver	2.0	2.0	2.9	-1.7	1.7	-1.1	-1.0	-1.2	1.6
Mg content in liver	1.9	1.9	3.6	-1.4	1.4	-1.2	-1.1	-1.3	1.9
Mn content in liver	0.1	0.1	0.3	-0.4	0.4	0.0	0.2	-0.2	0.5
Na content in liver	1.2	1.3	1.5	1.2	-1.2	1.1	1.0	1.2	-1.0
Rb content in liver	0.6	0.7	1.5	-1.0	1.0	-0.5	-0.5	-0.6	1.2
Se content in liver	0.9	1.2	2.2	-1.1	1.1	-0.9	-0.8	-1.0	1.5
Sr content in liver	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.4	-0.3	-0.1
Zn content in liver	2.0	2.2	2.6	-1.6	1.6	-1.4	-1.4	-1.4	1.6
Bone: minimum diameter	0.4	0.8	2.1	-0.6	0.6	-0.8	-0.8	-0.9	1.5
Time in familiar zone, hab. session 1	0.9	0.8	1.2	-0.8	0.8	-0.9	-0.9	-0.9	1.1
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.5	-0.4	0.3
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.5	-0.5	0.4	0.3	0.4	-0.3
Total locomotion distance, hab. session 1	0.6	0.8	1.0	1.0	-1.0	0.8	0.7	0.9	-1.0
Locomotion velocity, hab. session 1	1.3	1.9	2.2	1.4	-1.4	1.3	1.3	1.4	-1.5
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.5	0.5	-0.3	-0.3	-0.5	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.1	0.1	-0.3	-0.4	-0.2	-0.0
Total zone transitions, hab. session 2	0.3	0.3	0.8	-0.7	0.7	-0.3	-0.2	-0.4	0.9
Total locomotion distance, hab. session 2	0.2	0.2	0.4	-0.7	0.7	-0.2	-0.1	-0.4	0.6
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.5	0.5	0.0	0.1	-0.2	0.4
Novel to familiar place preference ratio	0.8	0.8	0.9	-0.9	0.9	-0.9	-1.0	-0.8	0.7
Novelty place preference	1.2	1.2	1.5	-1.1	1.1	-1.2	-1.2	-1.1	0.9
Time in novel zone, NPP test	1.2	1.2	1.5	-1.1	1.1	-1.2	-1.2	-1.1	0.9
Total zone transitions, NPP test	0.7	1.0	1.6	0.8	-0.8	1.2	1.2	1.1	-0.7
Total locomotion distance, NPP test	1.1	1.5	2.3	0.9	-0.9	1.5	1.5	1.4	-1.0
Locomotion velocity, NPP test	1.6	2.3	3.5	1.2	-1.2	1.8	1.9	1.7	-1.3
Intraocular pressure	5.3	7.4	8.7	-2.4	2.4	-2.9	-3.0	-2.8	2.7
Delta distance traveled before/after self-admin	2.1	2.3	2.7	-1.6	1.6	-1.4	-1.4	-1.5	1.6
Delta ambulatory time before/after self-admin	0.6	0.7	0.8	-0.9	0.9	-0.7	-0.7	-0.7	0.9
Parametrial fat weight	9.2	17.9	18.7	-4.2	4.2	-4.2	-4.2	-4.3	4.2
Pavlov. Cond. lever latency	0.6	0.7	1.2	-0.7	0.7	-1.0	-1.1	-0.9	0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.3	0.3	-0.1	-0.1	-0.2	0.6
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.0	-0.0	0.1	0.1	0.1	0.3
Pavlov. Cond. index score	0.1	0.1	0.2	0.2	-0.2	0.4	0.5	0.3	0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.1	-0.1	0.3	0.4	0.2	0.4
Pavlov. Cond. lever contacts	0.4	0.4	0.7	0.5	-0.5	0.8	0.8	0.7	-0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.3	-0.1	-0.3
Pavlov. Cond. intertrial magazine entries	2.1	2.6	3.2	1.6	-1.6	1.5	1.5	1.6	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	0.6	-0.6	0.9	1.0	0.8	-0.3
Pavlov. Cond. response bias	0.9	1.0	1.4	0.9	-0.9	1.2	1.2	1.1	-0.7
Pavlov. Cond. lever latency	1.0	1.3	1.8	-0.8	0.8	-1.3	-1.4	-1.2	1.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	0.4	0.2	0.3	0.0	-0.1
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.1	-0.1	0.5	0.5	0.3	-0.6
Pavlov. Cond. index score	0.4	0.5	0.9	0.3	-0.3	0.9	0.9	0.7	-0.9
Pavlov. Cond. latency score	0.4	0.5	0.9	0.3	-0.3	0.9	0.9	0.8	-0.9
Pavlov. Cond. lever contacts	0.3	0.4	0.7	0.3	-0.3	0.8	0.8	0.7	-0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.5	-0.5	0.1	-0.0	0.2	-0.1
Pavlov. Cond. intertrial magazine entries	2.7	3.5	4.2	-1.7	1.7	-2.0	-2.0	-1.9	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.0	-0.0	0.6	0.7	0.4	-0.6
Pavlov. Cond. response bias	0.6	0.8	1.2	0.5	-0.5	1.0	1.1	0.9	-1.0
Time in closed arm before self-admin	0.2	0.2	0.3	-0.4	0.4	-0.5	-0.5	-0.5	0.5
Time in closed arm after self-admin	0.8	0.9	1.0	-0.8	0.8	-1.0	-1.0	-0.9	0.9
Time in open arm before self-admin	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.2	-0.2	-0.1
Time in open arm after self-admin	0.6	0.6	0.9	0.7	-0.7	0.9	0.9	0.8	-0.6
Bone: periosteal estimation	0.1	0.3	0.4	0.5	-0.5	0.6	0.6	0.4	0.1
Bone: periosteal perimeter	0.0	0.0	0.2	-0.1	0.1	0.0	0.1	-0.1	0.4
Bone: post-yield work	1.6	2.2	2.7	1.7	-1.7	1.4	1.3	1.5	-1.3
Progressive ratio test 1 active lever presses	3.5	3.7	4.4	2.1	-2.1	1.8	1.8	1.8	-1.8
Progressive ratio test 1 breakpoint	2.9	3.0	3.6	1.9	-1.9	1.6	1.6	1.6	-1.6
Progressive ratio test 1 inactive lever presses	6.0	6.6	6.9	2.5	-2.5	2.6	2.6	2.6	-2.5
Progressive ratio test 2 active lever presses	1.8	1.9	2.9	1.7	-1.7	1.1	1.0	1.3	-1.3
Progressive ratio test 2 breakpoint	1.9	2.1	3.1	1.8	-1.8	1.2	1.1	1.4	-1.4
Progressive ratio test 2 inactive lever presses	3.1	3.6	3.8	1.9	-1.9	1.9	1.9	1.9	-1.7
Incentive Sensitization - Responses	0.6	0.6	1.0	1.0	-1.0	0.6	0.4	0.8	-0.8
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	0.8	-0.8	0.3	0.2	0.6	-0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.6	0.6	-0.0	0.1	-0.2	0.7
Progressive ratio	0.1	0.1	0.2	0.2	-0.2	0.4	0.4	0.4	-0.4
Food seeking constrained by brief footshock	12.3	15.1	17.6	4.2	-4.2	3.7	3.6	4.0	-3.6
Seeking ratio, punishment vs. effort	1.4	1.8	2.7	1.6	-1.6	1.1	1.1	1.3	-1.1
Retroperitoneal fat weight	28.1	92.2	98.1	-9.6	9.6	-9.8	-9.6	-9.9	9.2
Reaction time number correct	0.3	0.5	0.7	0.8	-0.8	0.6	0.7	0.6	-0.5
Reaction time mean minus median	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	0.0	-0.3
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.3	0.3	-0.2	-0.2	-0.2	0.0
Reaction time num false alarms	1.8	2.4	4.1	-1.8	1.8	-1.0	-0.9	-1.3	2.0
Reaction time num false alarms AUC	1.7	2.4	3.7	-1.9	1.9	-1.0	-0.9	-1.3	1.9
Reaction time trials correct on left	0.3	0.5	0.7	0.8	-0.8	0.6	0.7	0.6	-0.5
Reaction time trials on left	0.3	0.5	0.7	0.8	-0.8	0.6	0.7	0.6	-0.5
Reaction time mean	0.2	0.2	0.6	-0.2	0.2	-0.7	-0.8	-0.4	-0.1
Reaction time mean AUC	0.1	0.1	0.4	-0.1	0.1	-0.5	-0.6	-0.3	-0.2
Median of all reaction times	0.1	0.2	0.6	-0.1	0.1	-0.7	-0.8	-0.4	-0.2
Reaction time omissions	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.1	-0.3	0.4
Reaction time false alarm rate	2.4	3.3	4.9	-2.2	2.2	-1.4	-1.2	-1.6	2.0
Reaction time premature initiation rate	0.3	0.4	0.6	-0.8	0.8	-0.5	-0.5	-0.5	0.5
Reaction time premature initiations	0.0	0.0	0.1	-0.3	0.3	-0.1	-0.1	-0.1	0.1
Std. dev. reaction times	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.5	-0.5	0.1
Reaction time trials completed	0.3	0.5	0.7	0.8	-0.8	0.6	0.7	0.6	-0.5
Reaction time trials AUC	0.4	0.6	0.7	0.8	-0.8	0.7	0.8	0.6	-0.6
Run reversals in cocaine runway, females	0.3	0.3	1.1	0.6	-0.6	0.2	0.1	0.4	-1.0
Run reversals in cocaine runway, males	1.1	1.0	1.6	1.3	-1.3	0.8	0.7	0.9	-1.0
Latency to leave start box in cocaine runway	0.7	0.8	1.5	0.8	-0.8	0.8	0.8	0.8	-1.2
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.2	-0.2	0.6	0.6	0.5	-0.6
Latency to leave start box in cocaine runway, M	2.3	2.2	2.9	1.6	-1.6	1.3	1.3	1.3	-1.7
Std. dev. time between licks in bursts	0.9	1.1	1.6	-1.3	1.3	-0.9	-0.9	-1.0	0.9
Total sessions with >9 infusions	6.8	7.5	8.3	2.9	-2.9	2.6	2.6	2.8	-2.7
Short access day 1 total inactive lever presses	4.3	4.8	5.5	2.4	-2.4	2.2	2.2	2.1	-1.9
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.3	0.3	0.3	0.4	0.0	0.5
Short access day 1 total infusions	6.4	6.8	7.1	2.6	-2.6	2.6	2.7	2.6	-2.5
Short access day 10 total infusions	7.2	8.0	9.1	3.0	-3.0	2.7	2.6	2.7	-2.9
Short access total infusions	5.9	6.6	7.2	2.7	-2.7	2.5	2.5	2.5	-2.6
Short access day 1 locomotion	7.2	7.7	9.1	2.5	-2.5	3.0	3.0	2.9	-2.8
Short access day 10 total locomotion	1.0	1.2	1.5	0.9	-0.9	1.2	1.2	1.2	-1.0
Short access total locomotion	2.2	2.3	2.4	1.5	-1.5	1.5	1.4	1.6	-1.5
One hour access (0.3 mA shock)	3.0	3.5	5.0	2.2	-2.2	1.7	1.6	1.7	-1.6
Compulsive drug intake	2.8	2.8	3.3	-1.7	1.7	-1.5	-1.5	-1.7	1.8
One hour access (shock baseline)	6.1	7.0	9.2	3.0	-3.0	2.4	2.3	2.5	-2.6
Social response proportion	0.1	0.1	0.4	0.6	-0.6	0.1	-0.0	0.2	-0.4
Social responses	0.1	0.1	0.3	-0.2	0.2	-0.3	-0.3	-0.4	0.5
Social time	0.1	0.2	0.5	0.7	-0.7	0.0	-0.1	0.2	-0.2
Soleus weight	3.3	9.6	10.7	3.3	-3.3	3.2	3.2	3.0	-2.7
Bone: stiffness	0.1	0.2	0.5	-0.2	0.2	-0.4	-0.4	-0.4	0.7
Tibialis anterior weight	1.2	4.3	7.0	1.7	-1.7	2.5	2.7	2.1	-1.4
Time to tail flick, vehicle, before self-admin	1.1	1.2	1.4	-1.2	1.2	-1.1	-1.2	-1.0	0.7
Time to tail flick, vehicle, after self-admin	4.6	4.9	5.8	-2.2	2.2	-2.4	-2.3	-2.4	1.6
Time to tail flick, test, before self-admin	1.0	0.9	1.7	0.7	-0.7	1.0	1.0	1.0	-1.3
Time to tail flick, test, after self-admin	0.6	0.6	1.0	1.0	-1.0	0.5	0.3	0.7	-0.8
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.1	-1.0	1.0	-0.8	-0.7	-1.1	0.9
Delta time to tail flick, test, before/after SA	1.4	1.2	1.9	1.4	-1.4	1.0	0.9	1.1	-0.8
Tibia length	1.0	2.8	4.5	-1.0	1.0	-2.0	-2.1	-1.8	1.9
Ambulatory time before self-admin	0.1	0.2	0.4	0.3	-0.3	0.3	0.3	0.4	-0.6
Ambulatory time after self-admin	0.2	0.2	0.4	-0.3	0.3	-0.6	-0.6	-0.5	0.5
Bone: tissue strength	0.5	0.5	0.8	-0.5	0.5	-0.9	-0.9	-0.8	0.3
Total heroin consumption	1.4	1.7	2.4	1.0	-1.0	1.5	1.5	1.4	-1.2
Bone: trabecular number	3.5	5.4	6.3	2.5	-2.5	2.4	2.4	2.3	-1.9
Bone: trabecular spacing	1.4	1.9	2.6	-1.3	1.3	-1.5	-1.6	-1.3	1.1
Bone: trabecular thickness	0.5	0.6	0.7	0.8	-0.8	0.8	0.8	0.7	-0.8
Bone: trabecular tissue density	0.2	0.3	0.5	0.3	-0.3	0.6	0.6	0.5	-0.7
Water consumed over 24 hours	0.1	0.1	0.3	0.0	-0.0	0.5	0.6	0.2	-0.0
Number of responses in last shaping day	2.3	2.3	2.9	1.7	-1.7	1.4	1.3	1.5	-1.5