Hub : Genes

Slc35f6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Slc35f6 0.17 0.14 2.1e-03 0.12 0.05 0.11 0.09 1.1e-03 3.0e-02 1.7e-03 3.5e-03
2 IC gene expression Slc35f6 0.05 0.04 6.3e-03 0.03 0.04 0.03 0.03 2.1e-02 8.6e-03 1.8e-02 2.0e-02
3 Brain gene expression Slc35f6 0.04 0.03 4.1e-05 0.05 0.05 0.05 0.05 8.0e-06 1.7e-05 1.2e-05 9.7e-06
4 PL gene expression Slc35f6 0.02 0.02 5.9e-03 0.01 0.01 0.01 0.01 1.6e-02 3.0e-02 1.7e-02 1.2e-02
5 BLA gene expression Slc35f6 0.07 0.06 6.0e-04 0.06 0.05 0.05 0.05 6.4e-04 1.4e-03 1.3e-03 1.7e-03
6 pVTA gene expression Slc35f6 0.06 0.05 1.8e-04 0.03 0.03 0.03 0.02 1.7e-03 4.1e-03 2.4e-03 4.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density2.24.05.3-1.72.3-1.92.2-1.9-2.0
Area under the delay curve0.00.00.1-0.10.1-0.40.00.20.0
BMI with tail1.34.57.42.5-2.12.7-2.41.60.8
BMI without tail0.84.56.62.2-2.22.6-2.32.01.2
Body weight2.812.313.83.4-3.43.7-3.63.73.2
Weight adjusted by age0.10.20.50.30.0-0.00.4-0.7-0.7
Bone surface0.40.81.5-0.61.2-0.71.2-0.8-0.8
Bone volume0.71.42.5-1.11.6-1.11.3-0.9-0.9
Breakpoint value in progressive ratio session0.30.51.0-0.81.0-0.40.4-0.5-0.9
Number of licking bursts0.30.81.31.0-0.91.1-1.10.60.4
Context. condit. distance diff. score0.10.10.2-0.40.4-0.50.3-0.3-0.1
Locomotion velocity, session 10.40.50.70.8-0.60.4-0.70.80.8
Locomotion distance, session 10.40.50.9-0.30.9-1.00.9-0.4-0.5
Locomotion velocity, session 20.20.20.40.4-0.40.4-0.30.60.3
Locomotion distance, session 20.10.10.40.7-0.20.10.30.40.1
Locomotion velocity, session 30.70.81.7-0.20.6-0.50.9-1.3-1.2
Locomotion distance, session 30.20.20.30.50.2-0.20.6-0.5-0.5
Stereotopy head waving bouts, day 32.32.83.5-1.61.7-1.21.6-1.9-1.9
Stereotopy head waving duration, day 30.40.50.8-0.90.8-0.30.4-0.8-0.7
Locomotion velocity, session 70.10.10.30.10.40.20.3-0.3-0.5
Locomotion distance, session 70.60.81.41.2-0.61.0-0.90.90.4
Stereotopy head waving bouts, day 70.10.10.30.3-0.00.40.3-0.5-0.3
Stereotopy head waving duration, day 70.81.02.1-0.60.8-0.61.3-1.5-1.1
Locomotion velocity, session 80.40.50.9-0.60.7-0.61.0-0.6-0.5
Locomotion distance, session 80.20.30.6-0.40.6-0.60.8-0.4-0.4
Degree of sensitization distance1.51.62.50.9-1.01.3-1.61.41.2
Degree of sensitization stereotypy0.20.30.70.7-0.60.8-0.1-0.10.1
Conditioned locomotion4.04.75.1-2.32.1-2.22.2-2.2-2.0
Cocaine response after cond. corrected0.10.10.3-0.40.5-0.40.1-0.0-0.0
Cocaine response after cond. not corrected0.50.81.1-0.91.0-1.00.8-0.7-0.7
Cocaine response before conditioning3.33.94.7-1.81.7-1.92.2-2.1-2.1
Saline control response1.11.52.1-1.01.2-0.91.4-1.4-1.4
Bone: connectivity density1.82.83.7-1.21.9-1.41.9-1.7-1.8
Bone: cortical apparent density0.10.10.2-0.40.4-0.30.1-0.3-0.5
Bone: cortical area0.00.00.10.40.20.20.10.20.2
Bone: cortical porosity2.93.24.1-1.51.7-2.02.0-1.8-1.7
Bone: cortical porosity2.32.53.3-1.41.6-1.81.8-1.5-1.4
Bone: cortical thickness0.20.30.50.6-0.50.6-0.40.60.7
Bone: cortical thickness0.40.50.7-0.70.8-0.70.8-0.5-0.5
Bone: cortical tissue density0.00.10.1-0.30.3-0.2-0.1-0.2-0.3
Condit. Reinf. active minus inactive responses1.72.02.91.3-1.31.3-1.71.41.3
Condit. Reinf. active-inactive response ratio1.61.72.11.1-1.21.2-1.41.41.4
Condit. Reinf. active responses0.00.10.20.2-0.1-0.0-0.40.30.1
Condit. Reinf. inactive responses1.01.31.8-0.91.2-1.21.1-1.1-1.3
Incentive salience index mean0.30.40.80.5-0.30.4-0.90.70.6
Condit. Reinf. lever presses0.30.50.9-0.81.0-0.90.4-0.3-0.4
Condit. Reinf. active minus inactive responses3.65.58.8-1.41.7-2.22.4-3.0-3.0
Condit. Reinf. active-inactive response ratio1.52.45.0-0.81.0-1.41.4-2.2-2.0
Condit. Reinf. active responses2.73.96.3-1.11.5-1.82.2-2.3-2.5
Condit. Reinf. inactive responses0.40.61.0-0.50.9-0.61.0-0.5-0.8
Condit. Reinf. lever presses2.33.34.3-1.51.5-1.82.0-2.0-2.1
Condit. Reinf. lever reinforcers received2.73.86.1-1.11.5-1.72.1-2.4-2.5
Conditioned reinforcement - actives1.76.710.6-3.32.5-2.92.4-2.3-1.9
Conditioned reinforcement - inactives1.84.88.7-3.02.5-2.11.2-2.1-2.0
Conditioned locomotion1.42.13.1-1.81.4-1.61.4-1.4-1.1
Patch foraging indifference point 0 sec0.41.22.41.5-1.01.2-1.10.90.8
Patch foraging indifference point AUC0.00.10.2-0.10.4-0.1-0.1-0.3-0.4
Delay disc. indifference point, 0s delay2.52.95.11.1-1.50.9-1.72.32.2
Delay disc. indifference point, 16s delay0.10.10.20.1-0.0-0.50.3-0.3-0.3
Delay disc. indifference point, 2s delay0.20.30.50.4-0.40.2-0.60.60.7
Delay disc. indifference point, 24s delay0.91.52.5-1.51.3-1.61.2-0.9-0.6
Delay disc. indifference point, 4s delay0.10.10.40.2-0.20.2-0.30.60.2
Delay disc. indifference point, 8s delay0.00.00.1-0.30.2-0.30.30.10.0
Indifference point function ln k0.41.11.8-1.21.0-1.11.3-0.7-0.7
Indifference point function log k0.41.11.8-1.21.0-1.11.3-0.7-0.7
Patch foraging total patch changes 0 sec0.41.32.51.6-1.11.3-1.20.80.7
Patch foraging total patch changes 12 sec1.72.33.41.5-1.41.6-1.81.41.3
Patch foraging total patch changes 18 sec0.51.32.31.5-1.01.5-1.10.70.6
Patch foraging total patch changes 24 sec0.41.52.11.5-1.41.3-1.30.90.9
Patch foraging total patch changes 6 sec1.11.93.81.9-1.31.5-1.50.90.8
Patch foraging time to switch 0 sec0.10.30.70.6-0.40.9-0.50.10.1
Patch foraging water rate 0 sec0.20.71.5-0.80.8-0.91.2-0.6-0.4
Patch foraging water rate 12 sec0.10.30.70.0-0.70.20.00.70.9
Patch foraging water rate 18 sec0.20.41.1-0.90.4-0.71.0-0.10.1
Patch foraging water rate 24 sec0.40.61.00.4-0.91.0-0.50.91.0
Patch foraging water rate 6 sec0.20.20.8-0.3-0.3-0.20.30.60.9
Seeking ratio, delayed vs. immediate footshock0.00.10.20.5-0.20.00.10.0-0.2
Distance traveled before self-admin0.10.30.6-0.70.2-0.80.70.20.4
Distance traveled after self-admin1.32.24.30.8-1.41.2-1.21.82.1
Extensor digitorum longus weight3.513.817.9-2.83.7-3.34.0-4.2-4.1
Bone: elastic displacement1.31.62.7-1.61.3-1.71.1-0.9-0.9
Bone: elastic work0.60.81.4-1.11.0-1.20.9-0.5-0.5
Bone: endosteal estimation0.10.20.5-0.30.7-0.10.5-0.0-0.2
Bone: endosteal perimeter0.00.00.1-0.00.30.00.10.20.1
Epididymis fat weight11.156.061.57.5-7.87.6-7.67.46.9
Delta time in closed arm before/after self-admin0.30.30.90.5-0.20.9-0.8-0.20.2
Delta time in open arm before/after self-admin0.10.10.6-0.10.2-0.00.1-0.1-0.8
Diff in mean of infusions in LGA sessions0.10.10.20.5-0.10.4-0.30.3-0.2
Delay discount exponential model param0.10.10.40.4-0.40.6-0.30.10.3
Extinction: sum of active levers before priming0.10.20.5-0.50.70.2-0.2-0.3-0.6
Active lever presses in extinction session 61.11.11.7-1.21.3-0.81.0-0.9-1.0
Bone: final force0.10.10.20.30.00.2-0.30.40.3
Bone: final moment0.00.10.20.20.00.1-0.20.50.4
Food consumed during 24 hour testing period0.00.00.10.2-0.0-0.00.1-0.3-0.3
Glucose0.60.91.61.3-1.00.9-1.00.50.8
Heart weight2.54.05.81.5-1.91.8-2.12.22.4
Delay discount hyperbolic model param0.00.00.10.1-0.20.30.0-0.10.1
Intermittent access intake day 1-15 change0.10.71.4-1.10.8-0.71.2-0.7-0.2
Intermittent access intake escalation0.00.30.6-0.70.4-0.40.8-0.30.1
Intermittent access intake escalation 20.00.10.2-0.20.10.10.5-0.20.1
Intermitt. access day 1 inactive lever presses0.11.82.9-1.11.3-1.21.1-1.7-1.6
Intermitt. access day 15 inactive lever presses0.73.77.1-1.51.9-1.51.4-2.3-2.7
Intermitt. access escalation Index1.34.07.12.7-1.92.7-1.91.30.8
Intermittent access day 1 total infusions2.06.06.8-2.62.4-2.62.3-2.4-2.5
Intermittent access day 15 total infusions1.53.64.8-2.21.9-2.02.0-1.7-1.5
Intermittent access terminal intake (last 3 days)2.95.26.8-2.62.2-2.52.4-2.0-1.8
Intermittent access total infusions4.85.78.0-2.82.3-2.62.4-2.2-1.9
Intermittent access day 1 locomotion1.73.13.6-1.91.8-1.81.3-1.8-1.9
Intermittent access day 15 total locomotion0.10.61.0-1.00.6-0.60.4-0.9-0.8
Intermittent access total locomotion1.21.42.8-1.71.2-1.00.7-1.2-1.1
Intermittent access standard deviation0.42.12.6-1.61.5-1.51.3-1.4-1.4
Left kidney weight0.00.10.1-0.40.40.00.00.20.1
Right kidney weight0.21.52.50.7-0.91.1-1.21.61.5
Cocaine induced anxiety0.00.10.2-0.10.30.3-0.3-0.4-0.5
Post-drug Anxiety1.82.02.61.4-1.41.5-1.61.41.2
Baseline Anxiety2.13.55.11.9-2.11.4-1.62.31.9
Tail length0.20.92.20.2-0.60.4-0.51.51.5
Length with tail0.93.97.71.1-1.61.4-1.62.62.8
Length without tail0.31.42.50.9-0.71.0-1.01.61.6
Times rat made contact with spout1.01.11.7-0.81.1-0.71.0-1.3-1.3
Lifetime Intake4.85.98.7-2.92.5-2.52.3-2.1-2.1
Liver weight, left3.25.58.11.9-2.22.0-2.32.92.6
Liver weight, right6.411.213.82.5-3.33.3-3.63.73.5
Locomotor activity0.81.32.91.0-0.91.2-1.71.00.7
Locomotor testing distance0.10.30.60.6-0.20.7-0.8-0.1-0.5
Locomotor testing rearing0.30.92.4-0.51.0-0.50.4-1.2-1.5
Locomotion in novel chamber0.00.00.10.1-0.20.30.10.0-0.2
Locomotion in novel chamber post-restriction1.54.45.32.2-2.12.3-2.21.82.0
Fecal boli incidents, locomotor time 10.51.22.2-1.51.2-1.01.5-0.6-0.5
Change in fecal boli incidents, locomotor task4.34.55.51.9-2.12.0-2.22.42.2
Time >=10cm from walls, locomotor time 10.20.20.7-0.90.3-0.50.40.30.3
Bouts of movement, locomotor time 10.60.81.80.30.5-0.31.0-1.3-1.2
Total resting periods, locomotor time 10.70.91.70.20.6-0.41.2-1.2-1.3
Rest time, locomotor task time 10.10.10.30.5-0.4-0.10.10.40.3
Distance moved, locomotor task time 10.30.71.30.1-0.71.0-1.11.00.8
Vertical activity count, locomotor time 10.10.40.90.2-0.50.5-0.60.90.6
Time >=10cm from walls, locomotor time 20.41.22.3-1.51.1-1.51.0-0.5-0.3
Bouts of movement, locomotor time 20.10.30.60.8-0.60.5-0.3-0.10.4
Total resting periods, locomotor time 20.10.20.70.9-0.50.4-0.1-0.40.1
Rest time, locomotor task time 20.30.40.80.10.5-0.60.9-0.7-0.9
Distance moved, locomotor task time 20.30.40.9-0.2-0.40.4-0.91.00.8
Vertical activity count, locomotor time 20.10.20.5-0.4-0.10.0-0.40.70.5
Light reinforcement 10.52.55.2-0.31.6-0.91.6-2.0-2.3
Light reinforcement 20.92.12.9-1.01.5-1.31.7-1.6-1.5
Bone: marrow area0.10.20.5-0.30.7-0.10.5-0.0-0.2
Bone: maximum diameter0.00.10.30.10.50.30.3-0.1-0.1
Bone: maximum force0.00.00.10.00.2-0.20.10.1-0.0
Bone: maximum moment0.00.00.1-0.10.3-0.30.20.0-0.0
Mean time between licks in bursts0.53.13.91.3-1.81.7-1.82.01.9
Mean num. licks in bursts0.41.11.8-1.11.1-1.11.3-1.0-0.7
Cd content in liver0.00.10.20.3-0.10.4-0.10.10.1
Co content in liver4.95.77.0-2.52.6-2.52.4-2.1-2.1
Cu content in liver0.30.40.9-0.80.6-1.00.5-0.3-0.4
Fe content in liver1.41.82.4-1.51.5-1.61.0-1.0-1.3
K content in liver0.30.30.60.5-0.10.4-0.70.80.6
Mg content in liver0.30.40.70.50.10.5-0.80.80.6
Mn content in liver0.80.91.91.4-0.51.2-1.10.60.5
Na content in liver1.41.52.9-1.71.3-1.61.1-0.7-0.7
Rb content in liver0.40.40.80.5-0.20.8-0.90.60.6
Se content in liver0.20.20.50.6-0.30.4-0.70.10.1
Sr content in liver0.20.20.3-0.60.0-0.50.50.20.3
Zn content in liver1.11.32.60.9-0.90.5-1.21.61.4
Bone: minimum diameter0.61.11.61.0-0.81.2-0.81.31.2
Time in familiar zone, hab. session 11.31.41.81.1-0.91.3-1.21.31.2
Time in novel zone, hab. session 10.10.10.20.4-0.50.4-0.3-0.2-0.0
Total zone transitions, hab. session 10.10.20.5-0.20.4-0.30.5-0.4-0.7
Total locomotion distance, hab. session 10.20.30.8-0.90.7-0.40.5-0.1-0.4
Locomotion velocity, hab. session 10.91.22.0-1.41.3-1.11.0-0.7-0.9
Time in familiar zone, hab. session 20.10.20.40.6-0.30.5-0.5-0.10.0
Time in novel zone, hab. session 20.20.20.6-0.0-0.30.2-0.40.70.7
Total zone transitions, hab. session 20.10.20.70.9-0.20.40.10.30.2
Total locomotion distance, hab. session 20.10.10.40.7-0.20.10.1-0.0-0.0
Locomotion velocity, hab. session 20.10.10.20.5-0.0-0.10.3-0.2-0.3
Novel to familiar place preference ratio0.81.01.30.9-1.01.2-0.81.11.0
Novelty place preference1.11.51.91.1-1.21.4-1.01.31.2
Time in novel zone, NPP test1.21.52.01.1-1.21.4-1.11.31.2
Total zone transitions, NPP test1.11.72.4-0.91.3-1.31.6-1.2-1.4
Total locomotion distance, NPP test1.62.22.8-1.11.5-1.41.6-1.7-1.6
Locomotion velocity, NPP test2.23.13.6-1.31.8-1.71.9-1.9-1.9
Intraocular pressure5.48.911.82.5-2.93.4-3.42.62.9
Delta distance traveled before/after self-admin2.32.53.11.5-1.71.8-1.71.41.4
Delta ambulatory time before/after self-admin0.50.91.41.0-0.81.2-1.10.80.7
Parametrial fat weight14.834.943.16.3-6.65.8-5.65.65.6
Pavlov. Cond. lever latency0.60.81.10.6-1.01.0-0.70.81.0
Pavlov. Cond. magazine entry latency0.00.00.10.4-0.00.1-0.3-0.0-0.0
Pavlov. Cond. change in total contacts0.00.00.0-0.10.2-0.2-0.20.1-0.1
Pavlov. Cond. index score0.10.10.20.10.4-0.2-0.0-0.2-0.4
Pavlov. Cond. latency score0.10.10.10.20.4-0.1-0.1-0.2-0.4
Pavlov. Cond. lever contacts0.40.40.7-0.50.9-0.80.5-0.5-0.7
Pavlov. Cond. magazine entry number0.00.10.1-0.1-0.30.2-0.00.30.3
Pavlov. Cond. intertrial magazine entries2.02.43.2-1.81.5-1.71.3-1.1-1.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.40.9-0.60.4-0.6-0.8
Pavlov. Cond. response bias0.60.71.1-0.71.0-0.90.7-0.8-0.8
Pavlov. Cond. lever latency1.62.23.11.2-1.21.5-1.71.51.8
Pavlov. Cond. magazine entry latency0.10.20.4-0.20.1-0.50.6-0.5-0.6
Pavlov. Cond. change in total contacts0.40.91.9-0.50.6-0.81.1-1.2-1.4
Pavlov. Cond. index score1.01.62.2-1.00.9-1.31.4-1.3-1.5
Pavlov. Cond. latency score1.01.72.3-1.00.9-1.41.5-1.4-1.5
Pavlov. Cond. lever contacts1.01.52.3-1.01.0-1.21.3-1.3-1.5
Pavlov. Cond. magazine entry number0.10.10.30.10.00.3-0.30.30.6
Pavlov. Cond. intertrial magazine entries2.24.85.42.1-2.22.2-2.22.22.3
Pavlov. Cond. lever-magazine prob. diff.0.60.91.4-0.60.6-1.01.0-1.0-1.2
Pavlov. Cond. response bias1.62.23.3-1.21.2-1.51.6-1.6-1.8
Time in closed arm before self-admin0.40.60.90.7-0.70.8-0.70.91.0
Time in closed arm after self-admin1.01.11.70.9-1.01.3-1.10.61.2
Time in open arm before self-admin0.00.00.10.10.00.00.2-0.30.0
Time in open arm after self-admin0.60.71.7-0.60.8-0.40.6-1.0-1.3
Bone: periosteal estimation0.10.20.6-0.30.8-0.10.6-0.1-0.2
Bone: periosteal perimeter0.00.00.1-0.00.3-0.00.20.0-0.0
Bone: post-yield work1.42.42.6-1.41.6-1.51.5-1.6-1.6
Progressive ratio test 1 active lever presses2.03.55.5-2.31.9-2.01.6-1.5-1.7
Progressive ratio test 1 breakpoint2.03.55.5-2.42.0-2.01.6-1.6-1.7
Progressive ratio test 1 inactive lever presses2.56.49.7-3.12.7-2.42.0-2.4-2.4
Progressive ratio test 2 active lever presses1.72.55.1-2.31.6-1.81.5-1.0-0.8
Progressive ratio test 2 breakpoint1.72.24.7-2.21.5-1.71.4-0.9-0.7
Progressive ratio test 2 inactive lever presses1.23.86.2-2.52.1-1.91.7-1.8-1.7
Incentive Sensitization - Responses0.41.02.1-1.41.1-1.11.0-0.6-0.3
Incentive Sensitization - Breakpoint0.30.71.5-1.20.9-0.90.8-0.4-0.1
Sum of active levers in priming session hrs 5-60.40.30.70.6-0.20.9-0.70.5-0.3
Progressive ratio0.00.10.10.3-0.10.2-0.10.30.2
Food seeking constrained by brief footshock7.29.012.0-3.43.5-2.82.8-2.6-2.7
Seeking ratio, punishment vs. effort0.61.32.0-1.41.2-1.11.0-1.0-1.0
Retroperitoneal fat weight27.0120.8140.611.9-11.711.4-10.910.49.5
Reaction time number correct0.20.61.2-0.40.6-0.71.1-0.8-0.9
Reaction time mean minus median0.00.20.3-0.50.1-0.60.3-0.5-0.5
Reaction time mean minus median AUC0.00.00.1-0.0-0.3-0.1-0.2-0.1-0.1
Reaction time num false alarms1.11.84.02.0-1.21.7-1.30.80.6
Reaction time num false alarms AUC0.81.94.22.0-1.21.7-1.40.80.5
Reaction time trials correct on left0.20.61.2-0.40.6-0.71.1-0.8-0.9
Reaction time trials on left0.20.61.2-0.40.7-0.61.1-0.9-0.9
Reaction time mean0.30.71.3-0.1-0.70.4-0.81.21.1
Reaction time mean AUC0.20.51.1-0.1-0.60.4-0.81.11.0
Median of all reaction times0.60.91.9-0.0-0.80.6-1.01.41.3
Reaction time omissions0.10.20.50.5-0.10.7-0.7-0.0-0.3
Reaction time false alarm rate1.82.54.32.1-1.51.8-1.81.21.0
Reaction time premature initiation rate0.00.10.20.4-0.40.0-0.10.1-0.1
Reaction time premature initiations0.00.10.20.2-0.0-0.20.4-0.4-0.5
Std. dev. reaction times0.00.10.3-0.1-0.50.1-0.40.40.4
Reaction time trials completed0.20.61.2-0.40.7-0.61.1-0.9-0.9
Reaction time trials AUC0.20.91.5-0.50.8-0.81.2-1.0-1.1
Run reversals in cocaine runway, females0.30.40.8-0.80.4-0.90.7-0.00.2
Run reversals in cocaine runway, males0.50.61.0-1.00.7-0.90.9-0.6-0.4
Latency to leave start box in cocaine runway0.81.12.2-1.10.9-1.51.1-0.6-1.0
Latency to leave start box in cocaine runway, F0.20.20.5-0.50.4-0.70.3-0.2-0.6
Latency to leave start box in cocaine runway, M1.00.91.8-1.00.7-1.31.3-0.5-0.6
Std. dev. time between licks in bursts0.71.32.31.1-1.01.5-1.40.90.7
Total sessions with >9 infusions2.22.74.3-2.11.8-1.71.5-1.4-1.3
Short access day 1 total inactive lever presses3.67.210.5-3.23.0-2.01.9-2.8-2.8
Short access day 10 total inactive lever presses0.42.54.4-0.91.6-1.31.2-2.1-2.1
Short access day 1 total infusions3.16.28.1-2.82.7-2.22.2-2.4-2.5
Short access day 10 total infusions2.94.87.9-2.82.3-2.42.0-1.8-1.8
Short access total infusions2.23.25.4-2.31.9-1.61.5-1.5-1.6
Short access day 1 locomotion3.25.36.6-2.42.2-2.22.3-2.6-2.2
Short access day 10 total locomotion0.72.84.1-1.41.6-1.51.7-2.0-1.7
Short access total locomotion0.71.12.0-1.41.1-0.90.9-1.0-0.9
One hour access (0.3 mA shock)2.93.45.2-2.31.8-2.12.0-1.6-1.2
Compulsive drug intake2.13.04.12.0-1.62.0-1.71.61.4
One hour access (shock baseline)2.46.49.7-3.12.4-2.82.6-2.2-1.7
Social response proportion0.20.30.8-0.3-0.1-0.3-0.10.70.9
Social responses0.20.20.40.7-0.4-0.0-0.20.60.6
Social time0.00.10.2-0.1-0.1-0.00.00.40.5
Soleus weight3.710.813.5-2.73.4-3.23.7-3.3-3.4
Bone: stiffness0.00.10.20.4-0.10.2-0.1-0.2-0.1
Tibialis anterior weight2.27.610.7-1.72.6-2.53.1-3.3-3.1
Time to tail flick, vehicle, before self-admin0.10.10.5-0.0-0.40.3-0.10.30.7
Time to tail flick, vehicle, after self-admin1.73.44.91.8-2.21.6-1.61.71.9
Time to tail flick, test, before self-admin0.10.10.3-0.60.40.10.1-0.5-0.4
Time to tail flick, test, after self-admin0.70.71.8-1.00.8-0.71.3-0.6-0.3
Delta time to tail flick, vehicle, before/after SA0.50.61.21.1-0.90.6-0.60.80.3
Delta time to tail flick, test, before/after SA1.62.03.1-1.51.5-1.61.8-1.1-1.0
Tibia length2.46.59.61.7-2.12.6-2.62.93.1
Ambulatory time before self-admin0.10.30.6-0.70.3-0.80.8-0.00.2
Ambulatory time after self-admin0.81.32.70.6-1.00.8-1.01.41.6
Bone: tissue strength0.50.50.90.5-0.90.5-0.50.70.9
Total heroin consumption2.02.33.1-1.51.7-1.21.4-1.7-1.6
Bone: trabecular number1.52.94.5-1.72.1-1.71.8-1.4-1.4
Bone: trabecular spacing1.11.62.01.0-1.41.3-1.41.21.1
Bone: trabecular thickness0.10.20.5-0.50.7-0.50.30.1-0.1
Bone: trabecular tissue density0.40.60.9-0.90.7-0.70.6-0.9-0.9
Water consumed over 24 hours0.00.10.20.4-0.10.1-0.1-0.2-0.3
Number of responses in last shaping day0.70.92.9-1.71.1-0.50.6-0.5-0.5