Hub : Genes

Prlhr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Prlhr	0.09	0.06	2.5e-03	0.07	0.02	0	0.03	5.1e-04	5.8e-02	3.2e-01	2.3e-02
2	NAcc	gene expression	Prlhr	0.17	0.09	2.7e-12	0.11	0.11	0.12	0.12	1.9e-12	5.9e-13	1.1e-13	1.6e-13
3	Brain	gene expression	Prlhr	0.03	0.02	9.5e-03	0.01	0.01	0	0.01	3.1e-02	1.4e-02	1.1e-01	2.6e-02
4	PL	gene expression	Prlhr	0.05	0.03	1.3e-03	0.01	0.02	0.02	0.02	9.9e-03	4.5e-03	4.4e-03	6.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	6.2	10.4	12.8	3.6	-3.1	3.2	-2.9
Area under the delay curve	0.9	0.9	2.7	-0.1	0.4	-0.9	1.6
BMI with tail	30.5	99.0	152.9	12.4	-12.0	8.7	-4.8
BMI without tail	19.6	40.4	58.6	7.7	-7.5	6.0	-3.3
Body weight	28.9	121.0	178.1	13.3	-13.2	9.8	-5.9
Weight adjusted by age	3.8	4.3	6.5	2.5	-2.5	2.0	-0.7
Bone surface	4.2	7.5	10.3	3.2	-2.7	2.8	-2.1
Bone volume	6.9	11.7	16.7	4.1	-3.8	3.2	-2.3
Breakpoint value in progressive ratio session	1.4	1.5	2.7	1.1	-1.6	1.3	-0.7
Number of licking bursts	0.4	0.5	0.9	0.3	-0.2	0.9	-1.0
Context. condit. distance diff. score	0.2	0.2	0.4	0.6	0.1	0.6	-0.5
Locomotion velocity, session 1	1.5	1.6	3.2	-1.6	1.8	-0.8	0.4
Locomotion distance, session 1	2.7	3.5	4.5	-1.7	2.1	-2.0	1.6
Locomotion velocity, session 2	1.4	1.7	2.1	-1.5	1.4	-1.3	1.0
Locomotion distance, session 2	0.2	0.3	0.8	0.9	-0.7	-0.1	0.4
Locomotion velocity, session 3	1.8	2.1	2.9	-1.7	1.7	-1.4	0.9
Locomotion distance, session 3	0.9	0.9	1.5	-1.1	1.2	-0.9	0.5
Stereotopy head waving bouts, day 3	1.3	1.5	2.3	-1.1	0.9	-1.5	1.3
Stereotopy head waving duration, day 3	1.9	2.2	2.9	-1.4	1.1	-1.7	1.7
Locomotion velocity, session 7	0.0	0.0	0.1	0.2	0.1	0.3	-0.1
Locomotion distance, session 7	1.1	1.4	1.9	1.4	-1.1	1.2	-1.0
Stereotopy head waving bouts, day 7	1.3	1.5	2.0	-1.1	1.3	-1.0	1.4
Stereotopy head waving duration, day 7	1.9	2.3	2.7	-1.4	1.6	-1.3	1.6
Locomotion velocity, session 8	0.6	0.7	1.7	-0.9	1.3	-0.1	-0.6
Locomotion distance, session 8	0.2	0.3	0.5	0.3	0.5	0.4	-0.7
Degree of sensitization distance	3.7	3.8	4.5	2.1	-2.1	2.0	-1.5
Degree of sensitization stereotypy	0.5	0.6	1.2	-0.4	0.8	-0.5	1.1
Conditioned locomotion	0.2	0.3	0.3	-0.6	0.5	-0.6	0.4
Cocaine response after cond. corrected	1.2	1.3	2.6	-1.2	1.0	-1.6	0.7
Cocaine response after cond. not corrected	1.6	1.8	3.1	-1.8	1.4	-1.4	0.2
Cocaine response before conditioning	0.8	0.9	1.8	-0.7	0.5	1.0	-1.4
Saline control response	1.2	1.6	2.3	-1.3	0.8	-1.5	1.3
Bone: connectivity density	1.3	2.0	2.6	1.5	-1.0	1.6	-1.5
Bone: cortical apparent density	6.2	8.2	10.8	-3.3	3.1	-3.1	1.7
Bone: cortical area	11.8	17.7	26.4	5.0	-5.1	3.8	-2.2
Bone: cortical porosity	1.9	2.1	2.7	1.5	-1.6	1.5	-1.1
Bone: cortical porosity	2.6	2.8	3.8	1.8	-1.9	1.7	-1.1
Bone: cortical thickness	7.1	11.7	20.4	4.1	-4.5	2.8	-1.4
Bone: cortical thickness	3.8	4.4	10.4	2.5	-3.2	0.9	0.2
Bone: cortical tissue density	6.8	9.0	12.0	-3.5	3.3	-3.2	1.7
Condit. Reinf. active minus inactive responses	0.5	0.5	1.4	0.1	0.6	0.5	-1.2
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.2	-0.9	1.5	-0.1	-0.3
Condit. Reinf. active responses	2.9	3.6	4.7	2.1	-1.4	1.8	-2.2
Condit. Reinf. inactive responses	6.5	7.7	10.0	3.2	-3.0	2.4	-2.4
Incentive salience index mean	0.5	0.6	1.6	0.6	0.2	0.7	-1.3
Condit. Reinf. lever presses	0.3	0.4	0.8	0.8	-0.2	0.5	-0.9
Condit. Reinf. active minus inactive responses	2.0	2.4	3.5	1.5	-1.4	1.9	-1.3
Condit. Reinf. active-inactive response ratio	1.3	1.3	2.0	1.2	-1.3	1.4	-0.5
Condit. Reinf. active responses	3.3	4.5	5.5	2.3	-2.0	2.4	-1.8
Condit. Reinf. inactive responses	1.7	2.1	2.6	1.6	-1.1	1.6	-1.4
Condit. Reinf. lever presses	2.9	4.0	5.0	2.2	-2.2	1.9	-1.6
Condit. Reinf. lever reinforcers received	2.5	3.5	4.5	1.9	-1.6	2.1	-1.9
Conditioned reinforcement - actives	5.2	5.2	9.4	-2.8	3.1	-1.8	0.5
Conditioned reinforcement - inactives	0.1	0.1	0.2	-0.3	0.0	-0.2	-0.4
Conditioned locomotion	2.5	3.0	6.2	-2.1	2.5	-1.3	-0.3
Patch foraging indifference point 0 sec	5.1	8.2	13.3	3.6	-3.6	2.3	-1.1
Patch foraging indifference point AUC	0.3	0.4	1.2	0.4	-1.1	-0.0	0.0
Delay disc. indifference point, 0s delay	0.3	0.3	0.5	0.7	-0.7	-0.0	0.6
Delay disc. indifference point, 16s delay	1.2	1.2	2.4	-0.5	1.2	-0.9	1.6
Delay disc. indifference point, 2s delay	1.1	1.3	2.8	-0.4	0.6	-1.3	1.7
Delay disc. indifference point, 24s delay	0.5	0.4	1.3	-0.2	0.2	-0.6	1.2
Delay disc. indifference point, 4s delay	0.7	0.8	2.2	-0.3	0.2	-0.9	1.5
Delay disc. indifference point, 8s delay	1.0	1.0	2.3	-0.5	0.5	-1.2	1.5
Indifference point function ln k	0.2	0.3	0.7	0.9	-0.6	0.5	-0.2
Indifference point function log k	0.2	0.3	0.7	0.9	-0.6	0.5	-0.2
Patch foraging total patch changes 0 sec	6.2	10.0	16.8	3.9	-4.1	2.5	-1.2
Patch foraging total patch changes 12 sec	4.5	5.9	9.3	2.9	-3.1	2.0	-1.3
Patch foraging total patch changes 18 sec	3.2	4.1	6.5	2.3	-2.5	1.8	-1.4
Patch foraging total patch changes 24 sec	1.1	1.4	2.8	1.1	-1.7	0.8	-0.9
Patch foraging total patch changes 6 sec	5.6	8.3	15.2	3.2	-3.9	2.3	-1.5
Patch foraging time to switch 0 sec	1.3	2.0	3.8	-1.8	1.9	-0.9	0.2
Patch foraging water rate 0 sec	2.7	4.3	7.9	2.8	-2.8	1.3	-0.3
Patch foraging water rate 12 sec	2.3	3.5	5.3	2.3	-2.3	1.7	-0.6
Patch foraging water rate 18 sec	0.7	1.0	1.9	1.4	-1.4	0.2	0.4
Patch foraging water rate 24 sec	3.4	4.8	9.9	2.9	-3.1	0.8	0.2
Patch foraging water rate 6 sec	1.6	2.3	5.0	1.9	-2.2	0.9	-0.3
Seeking ratio, delayed vs. immediate footshock	3.5	4.0	7.8	-2.3	2.8	-1.7	0.2
Distance traveled before self-admin	3.5	3.7	5.3	-1.7	1.3	-2.2	2.3
Distance traveled after self-admin	2.3	2.5	3.0	-1.7	1.5	-1.7	1.4
Extensor digitorum longus weight	2.2	8.8	12.8	3.3	-3.6	2.9	-1.8
Bone: elastic displacement	0.6	0.7	1.4	-0.8	-0.1	-0.9	1.2
Bone: elastic work	0.9	1.1	2.0	0.7	-1.4	-0.4	1.3
Bone: endosteal estimation	1.6	3.6	5.6	2.4	-2.1	1.8	-1.1
Bone: endosteal perimeter	1.6	3.3	5.9	2.4	-2.2	1.5	-0.3
Epididymis fat weight	42.2	98.2	139.8	11.8	-11.5	9.3	-5.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.2	-0.0	0.2	-0.6
Delta time in open arm before/after self-admin	2.1	2.0	3.8	0.4	-0.4	1.9	-1.9
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2
Delay discount exponential model param	1.1	1.1	3.2	0.2	-0.4	1.0	-1.8
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.3	-0.4	0.6	-0.5
Active lever presses in extinction session 6	0.9	0.8	2.3	0.8	-1.5	0.3	0.5
Bone: final force	7.1	11.4	18.7	4.3	-4.3	2.6	-1.4
Bone: final moment	7.9	12.8	20.0	4.5	-4.5	2.9	-1.6
Food consumed during 24 hour testing period	0.6	0.7	0.8	0.7	-0.8	0.9	-0.8
Glucose	3.1	4.7	6.7	2.5	-2.6	2.4	-0.7
Heart weight	5.7	8.0	13.4	3.7	-3.3	2.7	-0.8
Delay discount hyperbolic model param	1.2	1.3	3.5	0.3	-0.4	1.1	-1.9
Intermittent access intake day 1-15 change	0.0	0.0	0.1	-0.4	0.1	0.2	-0.0
Intermittent access intake escalation	0.1	0.1	0.2	-0.4	0.2	-0.3	0.3
Intermittent access intake escalation 2	0.1	0.1	0.2	0.1	-0.1	0.5	-0.4
Intermitt. access day 1 inactive lever presses	1.7	1.8	3.4	1.2	-1.9	1.3	-0.8
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.8	0.6	-1.3	0.1	0.7
Intermitt. access escalation Index	0.2	0.2	0.6	0.2	0.0	0.2	-0.8
Intermittent access day 1 total infusions	0.4	0.5	0.8	-0.9	0.8	-0.6	0.3
Intermittent access day 15 total infusions	0.6	0.6	1.1	-1.0	0.8	-0.8	0.4
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	-0.6	0.5	-0.5	0.3
Intermittent access total infusions	0.8	0.9	1.4	-1.2	1.1	-0.9	0.3
Intermittent access day 1 locomotion	1.5	1.6	2.8	-1.2	1.2	-1.7	0.7
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.2	-0.3	0.1	-0.1
Intermittent access total locomotion	0.7	0.8	1.4	-0.8	1.1	-1.2	0.4
Intermittent access standard deviation	0.4	0.4	0.9	-0.8	0.9	-0.0	-0.3
Left kidney weight	10.7	30.1	48.2	6.7	-6.9	4.5	-2.7
Right kidney weight	11.5	32.3	53.5	7.0	-7.3	4.4	-2.8
Cocaine induced anxiety	3.7	4.3	7.6	-2.6	2.8	-1.6	0.5
Post-drug Anxiety	0.7	0.7	1.7	-1.0	1.3	-0.6	0.0
Baseline Anxiety	2.5	2.7	4.1	2.0	-2.0	1.5	-0.8
Tail length	0.5	1.6	2.6	0.9	-1.3	1.6	-1.0
Length with tail	3.0	10.9	15.2	3.7	-3.9	3.2	-2.1
Length without tail	5.8	12.6	19.0	4.4	-4.2	3.1	-2.1
Times rat made contact with spout	1.5	1.7	2.1	1.4	-1.4	1.4	-1.0
Lifetime Intake	1.0	1.1	1.6	-1.3	1.2	-1.1	0.5
Liver weight, left	7.5	12.0	17.8	4.2	-4.0	3.2	-2.0
Liver weight, right	13.8	22.9	31.9	5.6	-5.5	4.5	-3.1
Locomotor activity	0.1	0.2	0.4	-0.6	0.6	-0.0	-0.1
Locomotor testing distance	0.5	0.9	1.7	-1.3	1.0	-0.8	0.5
Locomotor testing rearing	0.8	1.2	1.7	-1.3	0.6	-1.0	1.3
Locomotion in novel chamber	0.6	0.8	1.5	1.1	-1.2	-0.2	0.5
Locomotion in novel chamber post-restriction	1.1	1.4	3.0	-0.2	0.2	-1.5	1.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	0.2	0.4	0.4	0.2
Change in fecal boli incidents, locomotor task	2.0	1.9	2.3	1.2	-1.5	1.3	-1.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.2	0.4	0.1	-0.3
Bouts of movement, locomotor time 1	0.6	0.7	1.3	0.1	-0.5	1.0	-1.1
Total resting periods, locomotor time 1	0.4	0.5	0.8	0.1	-0.5	0.9	-0.9
Rest time, locomotor task time 1	0.1	0.1	0.3	0.3	-0.5	0.3	-0.4
Distance moved, locomotor task time 1	0.4	0.4	1.0	-0.2	0.2	-0.8	1.0
Vertical activity count, locomotor time 1	0.6	0.6	1.1	-0.3	0.5	-1.0	1.0
Time >=10cm from walls, locomotor time 2	0.8	0.8	1.5	1.2	-1.1	0.6	-0.5
Bouts of movement, locomotor time 2	0.5	0.6	1.3	-1.2	0.7	-0.6	0.3
Total resting periods, locomotor time 2	0.7	0.7	1.7	-1.3	0.7	-0.7	0.4
Rest time, locomotor task time 2	0.5	0.6	1.3	-1.1	0.8	-0.5	0.3
Distance moved, locomotor task time 2	0.2	0.2	0.6	0.8	-0.6	0.0	-0.0
Vertical activity count, locomotor time 2	0.2	0.3	0.6	0.8	-0.5	0.2	-0.4
Light reinforcement 1	0.0	0.1	0.1	0.1	-0.4	-0.3	0.1
Light reinforcement 2	0.3	0.4	1.0	-0.7	1.0	-0.2	0.0
Bone: marrow area	1.9	4.1	6.3	2.5	-2.2	1.9	-1.1
Bone: maximum diameter	5.9	10.8	15.0	3.9	-3.6	3.3	-2.1
Bone: maximum force	6.7	11.6	19.1	4.4	-4.1	2.8	-1.7
Bone: maximum moment	7.4	12.7	19.8	4.5	-4.3	3.0	-1.9
Mean time between licks in bursts	1.2	1.7	4.3	0.5	-0.2	1.5	-2.1
Mean num. licks in bursts	0.2	0.3	0.4	0.6	-0.7	-0.1	0.5
Cd content in liver	0.4	0.4	1.6	-0.2	0.2	0.4	-1.2
Co content in liver	0.3	0.3	0.7	0.8	-0.7	0.1	-0.3
Cu content in liver	0.1	0.1	0.3	0.4	-0.6	-0.0	-0.1
Fe content in liver	0.1	0.1	0.1	0.4	-0.2	0.2	-0.3
K content in liver	0.0	0.0	0.2	-0.1	-0.4	-0.2	0.1
Mg content in liver	0.5	0.5	1.0	-0.5	-0.1	-0.8	1.0
Mn content in liver	0.2	0.2	0.8	0.5	-0.9	0.1	0.0
Na content in liver	0.4	0.4	1.1	0.5	-1.1	0.3	0.5
Rb content in liver	1.3	1.6	2.0	-1.3	1.1	-1.4	1.2
Se content in liver	0.2	0.2	0.3	-0.5	0.5	-0.4	0.5
Sr content in liver	7.1	6.5	7.3	-2.5	2.4	-2.7	2.6
Zn content in liver	1.0	1.1	2.2	-0.5	0.1	-1.4	1.5
Bone: minimum diameter	5.2	9.6	13.8	3.7	-3.7	3.0	-1.6
Time in familiar zone, hab. session 1	0.6	0.5	0.9	1.0	-0.8	0.4	0.6
Time in novel zone, hab. session 1	1.7	1.6	3.3	-1.6	1.8	-0.5	-0.6
Total zone transitions, hab. session 1	0.4	0.5	1.3	0.1	0.1	-0.9	1.1
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.1	0.2	0.2	-0.4
Locomotion velocity, hab. session 1	0.1	0.2	0.3	0.4	-0.1	0.4	-0.6
Time in familiar zone, hab. session 2	1.0	1.0	2.1	0.2	0.4	1.3	-1.4
Time in novel zone, hab. session 2	0.5	0.5	1.2	-0.2	-0.0	-0.9	1.1
Total zone transitions, hab. session 2	0.2	0.2	0.6	0.2	-0.2	-0.5	0.8
Total locomotion distance, hab. session 2	0.5	0.7	1.1	1.1	-0.9	0.8	-0.5
Locomotion velocity, hab. session 2	0.5	0.7	1.2	1.1	-1.0	0.7	-0.3
Novel to familiar place preference ratio	0.6	0.7	1.6	0.5	-0.1	0.9	-1.3
Novelty place preference	0.4	0.4	1.0	0.2	0.1	0.7	-1.0
Time in novel zone, NPP test	0.9	0.9	2.0	0.5	0.1	1.2	-1.4
Total zone transitions, NPP test	0.6	0.8	1.5	1.2	-1.2	0.5	-0.3
Total locomotion distance, NPP test	0.6	0.8	1.4	1.2	-1.0	0.7	-0.6
Locomotion velocity, NPP test	0.4	0.6	1.5	0.9	-1.2	0.2	-0.3
Intraocular pressure	0.9	1.3	1.9	1.0	-0.7	1.3	-1.4
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.5	0.6	-0.0	-0.5
Delta ambulatory time before/after self-admin	0.2	0.2	0.6	-0.2	0.2	0.1	-0.8
Parametrial fat weight	29.0	56.5	77.7	8.7	-8.8	7.1	-4.7
Pavlov. Cond. lever latency	0.5	0.7	1.5	-1.2	0.9	-0.5	0.1
Pavlov. Cond. magazine entry latency	1.2	1.5	2.2	1.5	-1.2	1.2	-0.9
Pavlov. Cond. change in total contacts	3.0	3.2	4.4	2.1	-1.6	2.0	-1.4
Pavlov. Cond. index score	1.6	2.0	3.0	1.7	-1.4	1.4	-1.0
Pavlov. Cond. latency score	1.3	1.6	2.4	1.6	-1.3	1.3	-0.8
Pavlov. Cond. lever contacts	1.0	1.1	2.1	1.5	-1.1	1.0	-0.4
Pavlov. Cond. magazine entry number	1.7	2.2	2.7	-1.6	1.3	-1.5	1.3
Pavlov. Cond. intertrial magazine entries	3.7	4.5	6.2	2.5	-2.5	1.8	-1.6
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.4	1.8	-1.5	1.6	-1.2
Pavlov. Cond. response bias	0.9	1.2	2.1	1.5	-1.1	1.0	-0.5
Pavlov. Cond. lever latency	3.3	4.4	5.1	-2.1	1.9	-2.1	2.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	0.4	0.5	-0.4
Pavlov. Cond. change in total contacts	1.1	1.5	1.9	1.2	-1.0	1.2	-1.4
Pavlov. Cond. index score	1.2	1.5	2.0	1.3	-0.9	1.3	-1.4
Pavlov. Cond. latency score	1.3	1.6	2.0	1.3	-1.1	1.3	-1.4
Pavlov. Cond. lever contacts	1.9	2.5	3.0	1.7	-1.4	1.5	-1.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.6	0.1	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	2.7	3.6	7.7	2.0	-2.8	1.4	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.1	1.0	-0.7	0.9	-1.1
Pavlov. Cond. response bias	1.8	2.4	3.7	1.5	-1.0	1.7	-1.9
Time in closed arm before self-admin	0.6	0.7	1.2	-0.6	0.9	-0.7	1.1
Time in closed arm after self-admin	0.9	0.9	1.3	-1.0	1.2	-0.9	0.8
Time in open arm before self-admin	1.1	1.2	1.7	-1.3	1.3	-1.1	0.6
Time in open arm after self-admin	0.4	0.5	0.7	-0.5	0.7	0.7	-0.8
Bone: periosteal estimation	7.1	14.8	22.2	4.7	-4.6	3.5	-2.0
Bone: periosteal perimeter	6.7	11.1	17.7	4.1	-4.2	2.9	-1.1
Bone: post-yield work	3.1	4.3	5.6	2.4	-1.8	2.2	-1.9
Progressive ratio test 1 active lever presses	1.0	1.1	1.6	-1.3	0.9	-1.2	0.7
Progressive ratio test 1 breakpoint	1.1	1.2	1.7	-1.3	0.9	-1.2	0.9
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.2	-0.4	-0.1	-0.6
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.1	-0.2	-0.5	0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.2	-0.5	-0.4	0.6
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.6	0.5	-0.7	0.5	-0.8
Incentive Sensitization - Responses	0.5	0.5	1.0	1.0	-1.0	0.3	0.1
Incentive Sensitization - Breakpoint	0.5	0.5	1.0	1.0	-0.9	0.4	-0.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.3	-0.3	0.3	-0.6
Progressive ratio	3.5	4.0	5.7	-2.4	2.1	-2.1	1.4
Food seeking constrained by brief footshock	5.6	6.8	10.4	-3.2	3.1	-2.3	1.3
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	0.0	0.2	-0.3
Retroperitoneal fat weight	45.2	148.5	221.7	14.9	-14.4	11.1	-6.4
Reaction time number correct	0.1	0.1	0.3	0.6	-0.4	0.3	-0.2
Reaction time mean minus median	0.7	0.9	2.2	-0.4	0.2	-1.0	1.5
Reaction time mean minus median AUC	2.3	3.0	6.9	-1.0	0.7	-1.9	2.6
Reaction time num false alarms	1.0	1.4	2.6	1.6	-1.1	1.0	-0.7
Reaction time num false alarms AUC	0.9	1.2	2.7	1.6	-1.1	0.9	-0.4
Reaction time trials correct on left	0.1	0.1	0.3	0.6	-0.4	0.3	-0.2
Reaction time trials on left	0.1	0.1	0.3	0.6	-0.4	0.3	-0.2
Reaction time mean	3.7	5.1	5.9	-2.2	2.1	-2.4	2.4
Reaction time mean AUC	4.7	6.3	7.4	-2.4	2.3	-2.7	2.6
Median of all reaction times	4.4	6.0	6.9	-2.4	2.4	-2.6	2.5
Reaction time omissions	0.0	0.0	0.1	-0.3	0.3	-0.0	-0.1
Reaction time false alarm rate	0.7	1.0	2.0	1.4	-0.9	0.9	-0.5
Reaction time premature initiation rate	0.2	0.3	0.8	0.2	0.0	-0.6	0.9
Reaction time premature initiations	0.2	0.2	0.5	0.5	-0.3	-0.3	0.7
Std. dev. reaction times	0.6	0.8	2.0	-0.4	0.4	-0.9	1.4
Reaction time trials completed	0.1	0.1	0.3	0.6	-0.4	0.3	-0.2
Reaction time trials AUC	0.3	0.4	0.7	0.8	-0.6	0.6	-0.4
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.6	0.4	-0.5	0.4
Run reversals in cocaine runway, males	1.3	1.3	2.0	-1.2	0.6	-1.4	1.2
Latency to leave start box in cocaine runway	1.1	1.2	2.9	-1.7	1.2	-0.6	0.5
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	-0.7	0.3	0.1	0.0
Latency to leave start box in cocaine runway, M	1.5	1.4	2.2	-1.5	1.2	-1.1	0.9
Std. dev. time between licks in bursts	0.4	0.5	1.1	-0.2	0.8	0.3	-1.1
Total sessions with >9 infusions	0.4	0.5	1.3	-0.4	-0.1	-1.2	0.5
Short access day 1 total inactive lever presses	0.7	0.8	2.7	0.2	-0.5	0.4	-1.6
Short access day 10 total inactive lever presses	4.0	4.5	8.4	2.3	-2.9	1.5	-1.3
Short access day 1 total infusions	0.3	0.3	0.8	-0.5	0.3	-0.9	0.1
Short access day 10 total infusions	2.4	2.7	4.0	-2.0	2.0	-1.5	0.9
Short access total infusions	1.4	1.6	2.4	-1.4	1.2	-1.5	0.9
Short access day 1 locomotion	0.3	0.3	0.8	-0.4	-0.3	-0.9	0.4
Short access day 10 total locomotion	0.4	0.4	0.6	-0.6	0.8	-0.7	0.4
Short access total locomotion	2.4	2.5	4.8	-1.1	1.0	-2.2	1.7
One hour access (0.3 mA shock)	0.2	0.3	0.6	-0.8	0.3	-0.1	-0.6
Compulsive drug intake	1.5	1.5	2.2	0.9	-1.2	1.2	-1.5
One hour access (shock baseline)	1.0	1.1	2.0	-1.4	1.2	-1.0	0.4
Social response proportion	1.5	1.7	2.6	1.6	-1.0	1.1	-1.3
Social responses	3.4	4.3	6.1	2.5	-2.2	2.0	-1.5
Social time	0.0	0.0	0.0	0.1	-0.2	0.1	0.1
Soleus weight	2.1	6.0	13.2	3.1	-3.6	1.2	0.1
Bone: stiffness	2.9	4.6	8.1	2.8	-2.5	1.7	-1.1
Tibialis anterior weight	0.3	1.0	1.4	1.1	-1.2	0.9	-0.9
Time to tail flick, vehicle, before self-admin	1.5	1.5	2.1	1.1	-1.1	1.2	-1.5
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	0.7	-0.5	0.6	-0.1
Time to tail flick, test, before self-admin	2.0	1.9	2.9	-1.3	1.0	-1.7	1.4
Time to tail flick, test, after self-admin	1.3	1.4	1.8	1.1	-1.0	1.2	-1.3
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.7	0.4	-0.5	-0.0	1.3
Delta time to tail flick, test, before/after SA	6.2	5.6	7.2	2.4	-1.9	2.7	-2.4
Tibia length	0.4	1.0	1.9	1.4	-1.1	0.8	-0.5
Ambulatory time before self-admin	2.0	2.1	3.2	-1.3	0.8	-1.7	1.8
Ambulatory time after self-admin	2.5	2.8	3.9	-2.0	1.5	-1.8	1.2
Bone: tissue strength	0.3	0.3	0.7	-0.7	0.8	-0.2	-0.2
Total heroin consumption	2.5	3.0	5.6	2.0	-2.4	1.5	-0.2
Bone: trabecular number	3.3	5.1	6.2	2.5	-2.4	2.3	-1.9
Bone: trabecular spacing	2.4	3.1	5.9	-2.3	2.4	-1.1	0.2
Bone: trabecular thickness	10.8	12.9	21.1	4.3	-4.6	3.1	-1.7
Bone: trabecular tissue density	1.0	1.3	2.8	-1.3	1.7	-1.0	0.1
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.1
Number of responses in last shaping day	0.3	0.3	0.5	-0.6	0.5	-0.7	0.1