Hub : Genes

Prlhr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Prlhr	0.16	0.08	0.0e+00	0.14	0.14	0.15	0.15	2.1e-20	3.9e-20	5.0e-22	8.1e-22
2	PL	gene expression	Prlhr	0.03	0.02	9.9e-03	0	0	-0	0	1.1e-01	3.6e-01	3.8e-01	2.7e-01
3	IC	gene expression	Prlhr	0.18	0.13	8.9e-03	-0	0.03	0.02	0.01	4.2e-01	2.0e-02	4.1e-02	9.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	4.6	8.4	13.8	-3.7	-2.9	1.8
Area under the delay curve	1.1	1.7	3.9	0.6	0.9	-2.0
BMI with tail	15.7	54.8	130.3	-11.4	-5.8	-0.6
BMI without tail	6.2	32.9	76.5	-8.7	-4.7	-0.6
Body weight	15.3	66.9	150.5	-12.3	-7.1	-0.0
Weight adjusted by age	0.8	2.3	5.2	-2.3	-1.2	-0.5
Bone surface	2.8	5.4	9.2	-3.0	-2.4	1.1
Bone volume	3.6	7.2	14.7	-3.8	-2.5	0.9
Breakpoint value in progressive ratio session	0.7	1.3	2.1	-1.2	-0.5	-1.5
Number of licking bursts	0.1	0.5	1.0	-0.6	-1.0	0.2
Context. condit. distance diff. score	0.4	0.4	0.7	-0.6	-0.6	0.8
Locomotion velocity, session 1	0.6	0.7	2.1	1.4	-0.0	0.3
Locomotion distance, session 1	1.5	1.9	3.7	1.9	1.4	-0.0
Locomotion velocity, session 2	0.9	1.0	2.3	1.5	0.9	0.3
Locomotion distance, session 2	0.1	0.1	0.2	-0.5	0.4	0.1
Locomotion velocity, session 3	1.0	1.2	2.4	1.5	1.1	0.3
Locomotion distance, session 3	0.5	0.6	1.2	1.1	0.5	0.5
Stereotopy head waving bouts, day 3	1.0	1.2	1.8	1.3	1.2	-0.7
Stereotopy head waving duration, day 3	1.8	2.3	2.4	1.6	1.5	-1.4
Locomotion velocity, session 7	0.1	0.1	0.1	-0.2	-0.1	0.4
Locomotion distance, session 7	0.9	1.1	1.5	-1.2	-0.6	1.2
Stereotopy head waving bouts, day 7	2.3	2.7	5.4	1.3	0.9	-2.3
Stereotopy head waving duration, day 7	1.9	2.3	4.7	1.3	0.7	-2.2
Locomotion velocity, session 8	0.8	1.0	2.3	0.5	-0.6	1.5
Locomotion distance, session 8	0.9	1.3	3.4	-0.3	-0.7	1.8
Degree of sensitization distance	1.9	2.1	4.3	-2.1	-1.3	0.6
Degree of sensitization stereotypy	1.2	1.3	3.7	0.4	0.3	-1.9
Conditioned locomotion	0.1	0.1	0.1	0.3	0.3	-0.3
Cocaine response after cond. corrected	1.6	2.4	2.5	1.5	1.6	1.5
Cocaine response after cond. not corrected	1.8	2.6	3.2	1.8	1.2	1.8
Cocaine response before conditioning	0.6	0.7	1.9	-0.1	-1.4	0.5
Saline control response	1.0	1.4	2.0	1.4	1.4	-0.6
Bone: connectivity density	1.6	2.5	2.8	-1.7	-1.5	1.5
Bone: cortical apparent density	3.5	5.5	10.2	3.2	2.2	1.2
Bone: cortical area	6.1	10.0	22.3	-4.7	-2.7	-0.3
Bone: cortical porosity	0.5	0.6	1.1	-1.1	-0.8	0.2
Bone: cortical porosity	1.4	1.6	3.2	-1.8	-1.3	-0.1
Bone: cortical thickness	3.3	5.4	13.7	-3.7	-1.6	-0.3
Bone: cortical thickness	1.8	2.2	3.7	-1.9	0.5	-1.6
Bone: cortical tissue density	3.6	5.8	10.8	3.3	2.2	1.4
Condit. Reinf. active minus inactive responses	1.8	2.1	4.7	-0.4	-1.2	2.2
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.5	0.7	-0.7	1.2
Condit. Reinf. active responses	3.9	5.0	6.3	-2.2	-1.9	2.5
Condit. Reinf. inactive responses	4.5	5.8	10.6	-3.3	-1.9	1.8
Incentive salience index mean	1.8	2.3	5.1	-0.7	-1.1	2.3
Condit. Reinf. lever presses	0.9	1.3	3.2	-0.7	-0.5	1.8
Condit. Reinf. active minus inactive responses	1.3	2.0	3.5	-1.5	-1.9	-0.2
Condit. Reinf. active-inactive response ratio	0.8	1.3	1.6	-1.0	-1.3	-1.1
Condit. Reinf. active responses	2.4	3.5	5.5	-2.3	-2.2	0.2
Condit. Reinf. inactive responses	1.5	2.2	3.3	-1.8	-1.7	0.7
Condit. Reinf. lever presses	1.5	2.2	4.7	-2.2	-1.3	0.3
Condit. Reinf. lever reinforcers received	2.1	3.0	4.3	-2.0	-2.1	0.6
Conditioned reinforcement - actives	0.5	1.9	5.3	2.3	0.5	-0.0
Conditioned reinforcement - inactives	0.1	0.2	0.5	0.7	0.3	0.3
Conditioned locomotion	1.4	2.0	5.4	2.3	0.8	0.4
Patch foraging indifference point 0 sec	1.3	3.5	9.6	-3.1	-0.8	-0.7
Patch foraging indifference point AUC	0.2	0.4	0.8	-0.1	0.9	-0.5
Delay disc. indifference point, 0s delay	0.4	0.5	0.9	-0.1	0.7	-1.0
Delay disc. indifference point, 16s delay	0.9	1.3	3.3	0.7	0.4	-1.8
Delay disc. indifference point, 2s delay	1.6	1.8	2.5	1.0	1.6	-1.4
Delay disc. indifference point, 24s delay	0.9	1.5	3.6	0.4	0.8	-1.9
Delay disc. indifference point, 4s delay	1.2	1.3	3.1	0.6	0.7	-1.8
Delay disc. indifference point, 8s delay	0.8	1.4	2.3	0.8	1.1	-1.5
Indifference point function ln k	0.2	0.6	0.8	-0.9	-0.7	0.7
Indifference point function log k	0.2	0.6	0.8	-0.9	-0.7	0.7
Patch foraging total patch changes 0 sec	1.4	4.2	11.3	-3.4	-0.8	-0.8
Patch foraging total patch changes 12 sec	1.7	2.3	6.3	-2.5	-0.5	-0.4
Patch foraging total patch changes 18 sec	0.7	1.7	4.7	-2.2	-0.6	-0.1
Patch foraging total patch changes 24 sec	0.2	0.6	1.4	-1.2	0.6	-0.2
Patch foraging total patch changes 6 sec	1.6	2.7	7.8	-2.8	-0.0	-0.6
Patch foraging time to switch 0 sec	0.2	0.8	2.2	1.5	0.1	0.5
Patch foraging water rate 0 sec	0.5	1.8	5.0	-2.2	-0.3	-0.6
Patch foraging water rate 12 sec	0.4	1.8	4.1	-2.0	-0.9	-0.7
Patch foraging water rate 18 sec	0.2	0.5	0.8	-0.9	0.6	-0.6
Patch foraging water rate 24 sec	1.1	1.5	3.6	-1.9	0.5	-0.9
Patch foraging water rate 6 sec	0.6	0.9	2.5	-1.6	-0.2	-0.3
Seeking ratio, delayed vs. immediate footshock	2.2	3.2	5.5	1.9	0.6	2.3
Distance traveled before self-admin	2.0	4.3	7.0	2.7	2.3	-0.7
Distance traveled after self-admin	2.2	3.9	6.3	2.5	2.3	-0.4
Extensor digitorum longus weight	0.9	3.8	8.2	-2.9	-1.8	0.0
Bone: elastic displacement	1.1	1.3	2.0	1.0	1.0	-1.4
Bone: elastic work	1.2	1.6	3.4	-0.1	1.2	-1.9
Bone: endosteal estimation	1.0	2.4	4.4	-2.1	-1.7	-0.1
Bone: endosteal perimeter	1.0	2.5	4.1	-2.0	-1.3	-1.3
Epididymis fat weight	13.2	66.4	150.0	-12.2	-7.0	0.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	-0.1	0.1	0.7
Delta time in open arm before/after self-admin	2.0	2.3	4.7	-1.5	-2.2	0.2
Diff in mean of infusions in LGA sessions	0.6	1.1	2.8	0.0	0.6	-1.7
Delay discount exponential model param	1.5	2.0	4.5	-0.7	-1.1	2.1
Extinction: sum of active levers before priming	0.2	0.4	0.8	-0.9	-0.2	-0.5
Active lever presses in extinction session 6	1.6	1.6	3.5	-0.6	1.0	-1.9
Bone: final force	3.7	6.1	14.7	-3.8	-1.8	-0.4
Bone: final moment	4.3	7.0	16.4	-4.1	-2.1	-0.2
Food consumed during 24 hour testing period	0.2	0.3	0.5	-0.7	-0.6	0.3
Glucose	2.8	4.5	6.5	-2.5	-1.7	-2.0
Heart weight	8.0	12.9	26.5	-5.2	-3.5	-0.4
Delay discount hyperbolic model param	1.8	2.3	4.9	-0.8	-1.2	2.2
Intermittent access intake day 1-15 change	0.3	1.4	2.0	1.4	1.2	-0.9
Intermittent access intake escalation	0.1	0.8	1.3	1.2	0.7	-0.8
Intermittent access intake escalation 2	0.1	0.2	0.3	0.5	0.1	-0.6
Intermitt. access day 1 inactive lever presses	0.1	1.1	2.2	-1.5	-1.0	-0.0
Intermitt. access day 15 inactive lever presses	0.1	0.7	1.9	-0.2	0.4	-1.4
Intermitt. access escalation Index	0.2	0.6	1.2	-0.3	-0.7	1.1
Intermittent access day 1 total infusions	0.1	0.3	0.5	0.7	0.7	-0.0
Intermittent access day 15 total infusions	0.6	1.6	2.5	1.6	1.2	-0.8
Intermittent access terminal intake (last 3 days)	0.6	1.1	1.3	1.1	1.1	-0.8
Intermittent access total infusions	0.5	0.5	0.9	0.9	0.9	-0.0
Intermittent access day 1 locomotion	0.8	1.4	2.5	1.3	1.6	-0.2
Intermittent access day 15 total locomotion	0.3	1.0	1.3	0.8	1.1	-1.0
Intermittent access total locomotion	0.9	1.0	1.8	1.2	1.3	0.1
Intermittent access standard deviation	0.3	1.6	2.9	1.0	0.9	-1.7
Left kidney weight	2.6	20.9	49.8	-7.1	-3.6	-0.2
Right kidney weight	3.7	25.9	65.0	-8.1	-3.5	0.4
Cocaine induced anxiety	0.8	2.2	4.8	2.2	1.3	0.3
Post-drug Anxiety	0.2	0.3	0.4	-0.3	-0.6	0.6
Baseline Anxiety	2.0	3.3	6.2	-2.5	-1.9	-0.0
Tail length	0.2	0.9	1.9	-0.8	-1.4	-0.2
Length with tail	1.5	6.8	12.0	-3.5	-2.9	0.1
Length without tail	2.2	11.6	22.1	-4.7	-3.5	0.3
Times rat made contact with spout	0.9	1.1	1.9	-1.4	-1.1	0.1
Lifetime Intake	0.4	0.6	0.8	0.9	0.9	0.1
Liver weight, left	6.6	11.4	27.5	-5.2	-2.6	-0.0
Liver weight, right	5.0	8.8	18.9	-4.4	-2.3	1.4
Locomotor activity	0.1	0.1	0.2	0.4	-0.2	0.3
Locomotor testing distance	0.3	0.7	1.6	1.3	0.6	0.4
Locomotor testing rearing	0.5	1.9	2.1	1.5	1.3	-1.3
Locomotion in novel chamber	0.3	0.4	0.8	-0.6	0.9	0.4
Locomotion in novel chamber post-restriction	0.7	2.3	4.9	0.9	2.2	-1.1
Fecal boli incidents, locomotor time 1	0.2	0.4	0.7	-0.0	-0.7	-0.8
Change in fecal boli incidents, locomotor task	0.8	0.8	1.4	-1.2	-0.6	0.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.0	-0.3	0.4
Bouts of movement, locomotor time 1	0.2	0.3	0.5	-0.6	-0.7	0.1
Total resting periods, locomotor time 1	0.1	0.2	0.3	-0.4	-0.5	0.1
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.3	0.1	0.2
Distance moved, locomotor task time 1	0.2	0.7	1.1	0.5	1.1	-0.8
Vertical activity count, locomotor time 1	0.1	0.5	1.2	0.5	1.1	-0.3
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.1	-1.1	0.1	0.5
Bouts of movement, locomotor time 2	0.1	0.3	0.8	0.9	0.2	-0.3
Total resting periods, locomotor time 2	0.1	0.4	1.0	1.0	0.4	-0.3
Rest time, locomotor task time 2	0.2	0.3	0.7	0.8	0.2	-0.2
Distance moved, locomotor task time 2	0.2	0.2	0.5	-0.4	0.7	0.2
Vertical activity count, locomotor time 2	0.1	0.3	0.4	-0.5	0.4	0.7
Light reinforcement 1	0.1	0.4	0.7	0.1	0.8	0.8
Light reinforcement 2	0.1	0.3	0.6	0.7	-0.3	0.4
Bone: marrow area	1.1	2.7	4.9	-2.2	-1.8	-0.1
Bone: maximum diameter	3.7	7.4	14.7	-3.8	-2.7	-0.4
Bone: maximum force	3.1	6.1	13.8	-3.7	-2.1	0.2
Bone: maximum moment	3.6	6.9	14.9	-3.9	-2.4	0.4
Mean time between licks in bursts	0.5	2.8	3.7	-1.1	-1.9	1.9
Mean num. licks in bursts	0.0	0.1	0.2	-0.2	0.5	-0.0
Cd content in liver	0.7	0.8	1.3	1.0	1.2	-0.2
Co content in liver	0.2	0.3	0.7	-0.2	0.9	-0.0
Cu content in liver	0.1	0.1	0.1	0.1	0.4	-0.4
Fe content in liver	2.8	3.4	4.8	-2.2	-2.0	1.2
K content in liver	0.1	0.1	0.3	0.3	0.2	-0.5
Mg content in liver	1.5	1.7	2.1	1.1	1.3	-1.5
Mn content in liver	0.2	0.2	0.4	-0.0	0.5	-0.7
Na content in liver	1.1	1.3	3.7	-0.0	0.3	-1.9
Rb content in liver	0.2	0.2	0.5	0.3	0.1	-0.7
Se content in liver	0.1	0.1	0.2	0.4	0.2	-0.0
Sr content in liver	7.1	6.2	8.8	3.0	3.0	-1.0
Zn content in liver	2.0	2.3	3.3	1.8	1.7	-0.8
Bone: minimum diameter	3.2	6.1	11.6	-3.4	-2.5	-0.6
Time in familiar zone, hab. session 1	0.8	0.9	2.3	-0.5	-0.0	-1.5
Time in novel zone, hab. session 1	1.0	1.1	2.2	1.0	-0.4	1.5
Total zone transitions, hab. session 1	0.5	0.6	1.5	0.2	1.2	-0.6
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.3	-0.2	0.5
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.6	-0.3	0.7
Time in familiar zone, hab. session 2	1.3	1.5	2.8	-0.8	-1.7	1.1
Time in novel zone, hab. session 2	0.6	0.7	0.9	0.6	0.8	-0.9
Total zone transitions, hab. session 2	0.2	0.3	0.6	0.0	0.8	-0.5
Total locomotion distance, hab. session 2	0.4	0.5	1.0	-1.0	-0.6	0.1
Locomotion velocity, hab. session 2	0.3	0.4	1.0	-1.0	-0.4	-0.2
Novel to familiar place preference ratio	1.0	1.3	2.1	-0.8	-1.4	1.1
Novelty place preference	0.7	0.9	1.6	-0.4	-1.3	0.9
Time in novel zone, NPP test	1.6	1.9	3.9	-0.9	-2.0	1.1
Total zone transitions, NPP test	0.3	0.5	1.0	-1.0	0.1	0.6
Total locomotion distance, NPP test	0.5	0.7	1.1	-1.1	-0.2	0.9
Locomotion velocity, NPP test	0.4	0.6	0.9	-0.7	0.6	0.9
Intraocular pressure	0.5	0.9	1.2	-1.1	-1.1	0.5
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.4	0.5	0.0
Delta ambulatory time before/after self-admin	0.0	0.1	0.1	0.0	0.4	0.2
Parametrial fat weight	19.4	45.8	107.5	-10.4	-5.5	0.0
Pavlov. Cond. lever latency	0.3	0.3	0.8	0.9	0.4	-0.1
Pavlov. Cond. magazine entry latency	1.1	1.5	2.5	-1.6	-1.2	0.7
Pavlov. Cond. change in total contacts	2.8	3.1	4.6	-2.1	-2.1	0.3
Pavlov. Cond. index score	1.1	1.4	2.6	-1.6	-1.2	0.4
Pavlov. Cond. latency score	0.8	1.0	2.0	-1.4	-1.0	0.3
Pavlov. Cond. lever contacts	0.5	0.6	1.4	-1.2	-0.6	-0.3
Pavlov. Cond. magazine entry number	1.2	1.5	2.7	1.6	1.3	-0.5
Pavlov. Cond. intertrial magazine entries	2.2	2.6	5.2	-2.3	-1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	3.4	-1.8	-1.4	0.5
Pavlov. Cond. response bias	0.6	0.8	1.6	-1.3	-0.9	0.3
Pavlov. Cond. lever latency	2.1	2.9	4.6	2.1	1.8	-1.0
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	-0.5	-0.7	0.2
Pavlov. Cond. change in total contacts	0.4	1.0	1.5	-1.2	-1.1	0.5
Pavlov. Cond. index score	1.0	1.6	2.4	-1.6	-1.3	0.8
Pavlov. Cond. latency score	0.9	1.5	2.4	-1.5	-1.2	0.8
Pavlov. Cond. lever contacts	1.3	1.9	3.3	-1.8	-1.3	0.8
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.6	0.4	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.8	2.4	-1.5	-0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.4	-1.2	-1.0	0.6
Pavlov. Cond. response bias	2.0	2.7	3.7	-1.9	-1.9	1.0
Time in closed arm before self-admin	0.0	0.1	0.2	0.2	0.4	-0.1
Time in closed arm after self-admin	0.5	0.6	0.8	0.9	0.9	0.4
Time in open arm before self-admin	0.9	1.1	2.8	1.7	0.6	-0.3
Time in open arm after self-admin	0.6	0.7	1.9	-0.1	-1.4	-0.5
Bone: periosteal estimation	3.8	9.0	19.1	-4.4	-2.8	-0.2
Bone: periosteal perimeter	3.8	7.4	15.0	-3.9	-2.2	-1.5
Bone: post-yield work	2.5	4.3	5.3	-2.3	-2.1	1.7
Progressive ratio test 1 active lever presses	0.8	1.5	2.4	1.6	1.4	-0.4
Progressive ratio test 1 breakpoint	0.8	1.4	2.2	1.5	1.3	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.0	0.3	0.3
Progressive ratio test 2 active lever presses	0.5	0.7	1.1	0.7	1.1	-0.7
Progressive ratio test 2 breakpoint	0.4	0.5	0.9	0.6	0.9	-0.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	-0.3	-0.1	0.7
Incentive Sensitization - Responses	0.1	0.2	0.5	-0.2	0.2	-0.7
Incentive Sensitization - Breakpoint	0.0	0.1	0.3	-0.2	0.1	-0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.7	-0.2	-0.1
Progressive ratio	1.4	4.1	7.6	2.8	2.0	-0.8
Food seeking constrained by brief footshock	3.0	3.7	7.8	2.8	1.8	-0.6
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.3	-0.3	0.5
Retroperitoneal fat weight	21.7	97.0	225.0	-15.0	-8.1	0.6
Reaction time number correct	0.1	0.4	0.5	-0.6	-0.7	-0.4
Reaction time mean minus median	0.2	1.6	1.9	1.1	1.4	-1.3
Reaction time mean minus median AUC	0.7	4.6	5.3	1.9	2.2	-2.3
Reaction time num false alarms	0.6	1.0	1.5	-1.2	-0.7	1.0
Reaction time num false alarms AUC	0.3	0.6	1.3	-1.1	-0.6	0.5
Reaction time trials correct on left	0.1	0.4	0.5	-0.6	-0.7	-0.4
Reaction time trials on left	0.1	0.4	0.6	-0.6	-0.8	-0.4
Reaction time mean	2.0	4.5	6.6	2.6	2.2	-1.3
Reaction time mean AUC	2.3	5.5	8.1	2.8	2.5	-1.5
Median of all reaction times	3.0	4.7	7.5	2.7	2.3	-1.2
Reaction time omissions	0.0	0.0	0.0	-0.0	0.1	0.1
Reaction time false alarm rate	0.5	0.6	1.0	-1.0	-0.4	0.8
Reaction time premature initiation rate	0.3	0.5	1.3	0.3	1.1	-0.1
Reaction time premature initiations	0.1	0.2	0.4	-0.1	0.6	-0.5
Std. dev. reaction times	0.4	1.2	1.4	1.0	1.1	-1.2
Reaction time trials completed	0.1	0.4	0.6	-0.6	-0.8	-0.4
Reaction time trials AUC	0.2	0.6	0.9	-0.8	-0.9	-0.4
Run reversals in cocaine runway, females	0.2	0.2	0.4	0.6	0.4	-0.3
Run reversals in cocaine runway, males	1.6	1.8	3.6	1.3	1.9	-0.3
Latency to leave start box in cocaine runway	1.0	1.4	2.3	1.4	-0.0	-1.5
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	0.4	-0.5	-0.8
Latency to leave start box in cocaine runway, M	1.5	1.5	2.8	1.1	0.6	-1.7
Std. dev. time between licks in bursts	0.7	1.4	3.4	-0.1	-0.9	1.9
Total sessions with >9 infusions	1.0	1.3	2.6	1.1	1.6	0.3
Short access day 1 total inactive lever presses	0.9	1.9	4.3	-0.7	-0.9	2.1
Short access day 10 total inactive lever presses	0.2	1.5	3.9	-2.0	-0.7	0.5
Short access day 1 total infusions	0.2	0.4	0.7	0.4	0.6	0.8
Short access day 10 total infusions	1.0	1.6	3.8	2.0	1.0	-0.2
Short access total infusions	0.7	1.0	1.5	1.2	1.1	0.5
Short access day 1 locomotion	0.4	0.7	1.8	0.6	1.3	-0.3
Short access day 10 total locomotion	0.3	1.2	2.0	1.2	1.4	-0.5
Short access total locomotion	1.8	2.7	5.0	1.7	2.2	-0.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.4	0.0	0.1
Compulsive drug intake	1.1	1.6	2.7	-1.6	-1.1	1.0
One hour access (shock baseline)	0.4	1.0	2.2	1.5	0.9	-0.1
Social response proportion	1.9	2.4	3.3	-1.7	-1.1	1.8
Social responses	2.4	3.1	6.9	-2.6	-1.4	0.6
Social time	0.1	0.2	0.4	-0.2	-0.2	-0.6
Soleus weight	0.8	2.4	4.8	-2.2	0.3	-1.5
Bone: stiffness	1.5	2.7	5.8	-2.4	-1.5	0.4
Tibialis anterior weight	0.2	0.6	1.0	-1.0	-0.8	0.2
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.4	-0.6	-0.5	0.6
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.4	-0.0	0.4	-0.6
Time to tail flick, test, before self-admin	2.5	2.9	4.6	2.1	1.8	-0.8
Time to tail flick, test, after self-admin	1.3	1.4	1.9	-1.0	-1.1	1.4
Delta time to tail flick, vehicle, before/after SA	1.0	1.1	3.0	-0.1	0.5	-1.7
Delta time to tail flick, test, before/after SA	3.6	4.5	5.6	-2.4	-2.1	1.8
Tibia length	0.2	0.6	1.1	-1.1	-0.8	0.1
Ambulatory time before self-admin	1.0	3.0	4.6	2.1	2.0	-0.5
Ambulatory time after self-admin	2.3	3.6	5.6	2.4	2.3	-0.3
Bone: tissue strength	0.0	0.0	0.1	0.3	-0.2	-0.0
Total heroin consumption	2.1	2.5	4.1	-1.8	-0.0	-2.0
Bone: trabecular number	2.4	4.4	7.7	-2.8	-2.1	1.1
Bone: trabecular spacing	1.0	1.4	3.7	1.9	0.3	0.7
Bone: trabecular thickness	4.8	6.7	15.9	-4.0	-1.9	-0.7
Bone: trabecular tissue density	0.6	1.0	1.7	1.1	0.3	1.3
Water consumed over 24 hours	0.0	0.1	0.2	-0.1	0.0	-0.5
Number of responses in last shaping day	0.5	0.7	1.1	0.9	1.1	0.1