Hub : Genes

Cbx7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Cbx7 0.17 0.08 2.7e-09 0.08 0.1 0.09 0.1 8.0e-08 1.6e-09 9.8e-09 1.3e-09
2 OFC alternative TSS XM_006242020.4 0.2 0.11 7.6e-03 0.09 0.07 0.02 0.08 4.1e-03 1.1e-02 1.1e-01 5.0e-03
3 NAcc gene expression Cbx7 0.06 0.03 3.3e-06 0.04 0.04 0.05 0.05 3.8e-05 1.1e-05 2.4e-06 7.7e-07
4 pVTA mRNA stability Cbx7 0.1 0.06 2.7e-03 0.05 0.05 0.06 0.04 2.5e-03 3.5e-03 2.0e-03 6.0e-03
5 Liver isoform ratio XM_006242020.4 0.04 0.02 1.6e-03 0.03 0.02 0.01 0.02 7.4e-04 3.3e-03 6.1e-02 2.2e-03
6 BLA mRNA stability Cbx7 0.4 0.12 4.7e-15 0.27 0.24 0.24 0.26 1.2e-14 2.8e-13 4.9e-13 6.8e-14
7 PL gene expression Cbx7 0.12 0.06 4.1e-07 0.07 0.06 0.05 0.05 6.4e-08 8.2e-07 3.1e-06 1.3e-06
8 BLA isoform ratio XM_039079593.1 0.13 0.07 3.5e-04 0.04 0.03 0.02 0.03 4.8e-03 1.0e-02 3.1e-02 1.7e-02
9 Liver gene expression Cbx7 0.05 0.03 2.5e-04 0.01 0.03 0.03 0.02 1.7e-02 2.0e-04 9.3e-05 2.1e-03
10 Adipose alternative TSS XM_039079590.1 0.02 0.02 6.2e-03 0.01 0.01 0.01 0.01 8.8e-03 5.2e-02 5.4e-02 6.3e-02
11 PL mRNA stability Cbx7 0.23 0.08 0.0e+00 0.23 0.22 0.23 0.23 7.5e-25 8.5e-24 8.9e-25 1.4e-24
12 Liver mRNA stability Cbx7 0.08 0.04 3.4e-07 0.07 0.06 0.06 0.07 1.9e-08 6.1e-07 2.5e-07 4.6e-08
13 NAcc mRNA stability Cbx7 0.18 0.07 1.1e-16 0.15 0.15 0.15 0.15 1.1e-16 6.1e-17 5.3e-17 1.3e-16
14 Adipose isoform ratio XM_039079590.1 0.04 0.02 8.5e-04 0.02 0.02 0.03 0.01 4.9e-03 3.0e-03 4.1e-04 1.6e-02
15 RMTg mRNA stability Cbx7 0.25 0.12 6.5e-03 0.02 0.06 0.06 0.04 1.1e-01 9.8e-03 1.2e-02 2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.20.6-0.8-0.80.60.40.50.00.0-0.00.40.40.60.50.2-0.8-0.4
Area under the delay curve1.21.24.4-1.6-2.02.10.30.1-0.9-1.0-0.2-1.4-0.4-0.7-0.7-0.8-0.31.2
BMI with tail0.20.53.10.50.8-1.40.5-0.2-0.3-0.30.2-0.20.10.30.70.6-0.1-1.7
BMI without tail0.71.54.7-1.3-1.1-0.01.9-0.80.90.90.9-0.20.71.31.61.6-0.7-2.2
Body weight0.52.18.42.92.7-2.9-1.00.8-1.0-1.0-0.51.4-0.4-0.7-0.4-0.6-0.3-0.6
Weight adjusted by age0.30.31.10.30.2-1.00.2-0.30.50.50.5-0.60.60.40.70.51.00.6
Bone surface0.10.20.7-0.3-0.20.2-0.30.5-0.9-0.9-0.10.1-0.3-0.4-0.5-0.7-0.30.6
Bone volume0.10.10.2-0.4-0.40.30.20.4-0.4-0.40.2-0.20.30.30.2-0.2-0.20.0
Breakpoint value in progressive ratio session0.10.10.5-0.6-0.30.50.4-0.00.20.0-0.00.3-0.30.00.10.1-0.7-0.5
Number of licking bursts0.40.42.3-0.6-0.61.50.4-0.4-0.3-0.40.3-0.60.5-0.4-0.1-0.21.01.0
Context. condit. distance diff. score1.62.07.82.82.4-2.5-0.0-0.51.01.00.80.11.20.91.00.91.1-1.2
Locomotion velocity, session 12.02.15.40.70.60.1-1.81.1-1.7-1.7-1.00.2-1.4-2.3-2.2-1.90.02.0
Locomotion distance, session 11.41.84.6-2.1-1.91.6-0.20.2-1.3-1.3-0.2-1.5-0.5-1.3-1.6-1.40.52.1
Locomotion velocity, session 20.20.21.00.30.6-1.0-0.40.1-0.7-0.7-0.2-0.1-0.6-0.6-0.4-0.20.3-0.4
Locomotion distance, session 21.82.56.0-2.5-2.02.0-0.61.1-1.6-1.6-1.0-0.4-1.7-1.6-1.8-1.7-0.91.6
Locomotion velocity, session 31.01.13.00.70.7-1.00.6-1.40.70.71.4-1.31.61.11.00.81.70.2
Locomotion distance, session 31.92.16.0-1.1-1.00.61.4-2.10.50.51.9-2.51.90.90.80.72.21.2
Stereotopy head waving bouts, day 31.01.22.31.01.5-0.1-1.41.0-1.2-1.2-1.01.3-1.1-1.3-1.1-1.0-0.70.2
Stereotopy head waving duration, day 31.72.16.02.22.4-1.5-1.81.4-1.1-1.1-1.22.0-1.2-1.2-0.9-0.8-0.8-0.6
Locomotion velocity, session 70.50.53.71.91.5-0.4-0.50.00.20.20.1-0.30.1-0.1-0.1-0.30.80.1
Locomotion distance, session 71.01.32.61.00.51.2-1.41.2-1.1-1.1-0.80.3-1.2-1.4-1.3-1.6-0.11.5
Stereotopy head waving bouts, day 71.41.67.22.32.2-2.7-0.2-0.60.40.40.30.41.00.60.70.90.9-1.3
Stereotopy head waving duration, day 72.22.67.31.61.6-2.70.9-1.31.41.41.0-0.11.71.71.82.01.1-2.3
Locomotion velocity, session 81.31.66.22.51.8-1.6-1.50.4-1.1-1.1-0.60.8-1.0-1.2-1.3-1.10.40.5
Locomotion distance, session 80.20.31.60.30.1-1.30.2-0.10.80.80.3-0.50.40.80.60.50.3-0.7
Degree of sensitization distance3.43.47.92.11.8-0.2-2.32.6-0.9-0.9-2.32.8-2.4-1.4-1.2-1.5-2.1-0.6
Degree of sensitization stereotypy1.71.88.21.51.3-2.90.6-1.30.90.90.8-0.51.61.21.21.41.4-1.4
Conditioned locomotion0.20.21.00.80.5-1.0-0.50.90.30.3-0.40.30.10.3-0.10.2-0.1-0.2
Cocaine response after cond. corrected0.50.52.10.10.50.1-1.01.0-0.4-0.5-1.50.5-1.0-0.6-0.7-0.7-0.80.2
Cocaine response after cond. not corrected0.20.21.0-0.20.20.2-0.50.30.10.1-1.00.4-0.70.0-0.2-0.2-0.6-0.4
Cocaine response before conditioning0.80.92.4-0.4-0.60.31.3-1.51.00.91.1-0.61.11.11.01.10.7-1.0
Saline control response0.81.03.50.10.1-0.80.50.31.81.90.50.11.01.41.41.20.3-0.9
Bone: connectivity density0.10.10.6-0.1-0.10.2-0.20.3-0.3-0.3-0.10.7-0.1-0.1-0.2-0.5-0.50.2
Bone: cortical apparent density1.01.33.9-0.4-0.50.31.5-1.90.40.42.0-1.41.30.71.10.81.70.7
Bone: cortical area0.60.92.10.81.2-0.6-1.01.1-1.4-1.4-0.60.5-1.0-0.9-0.8-0.9-0.3-0.1
Bone: cortical porosity1.41.64.81.41.1-1.2-1.31.90.20.2-2.21.5-1.20.3-0.30.0-1.7-1.6
Bone: cortical porosity2.32.57.01.61.7-1.6-2.02.5-0.3-0.3-2.61.7-1.7-0.4-0.9-0.4-1.9-1.4
Bone: cortical thickness0.20.31.2-0.30.00.9-0.10.1-1.1-1.10.1-0.6-0.3-0.7-0.6-0.70.30.3
Bone: cortical thickness0.81.02.7-1.0-0.61.1-0.50.7-1.6-1.6-0.4-0.5-0.6-1.2-1.3-1.10.11.0
Bone: cortical tissue density0.91.23.4-0.3-0.40.21.3-1.80.40.41.9-1.41.20.61.00.81.70.8
Condit. Reinf. active minus inactive responses0.20.20.9-0.5-0.00.8-0.30.4-0.6-0.6-0.1-0.1-0.3-0.5-0.2-0.5-0.10.9
Condit. Reinf. active-inactive response ratio0.10.10.20.20.50.3-0.1-0.1-0.0-0.10.4-0.50.20.10.40.00.40.5
Condit. Reinf. active responses0.50.62.8-1.7-1.21.00.9-0.30.40.30.7-0.00.50.50.80.4-0.30.3
Condit. Reinf. inactive responses1.31.64.6-2.0-2.10.61.8-1.21.11.11.30.21.31.11.31.0-0.3-0.3
Incentive salience index mean0.20.21.1-1.1-0.50.90.10.1-0.3-0.40.1-0.2-0.1-0.10.1-0.3-0.20.8
Condit. Reinf. lever presses0.10.21.3-1.1-0.70.40.5-0.20.00.10.3-0.10.20.30.30.1-0.20.2
Condit. Reinf. active minus inactive responses1.82.24.20.00.61.4-1.61.1-1.7-1.8-1.60.0-1.8-2.1-2.0-1.9-0.61.8
Condit. Reinf. active-inactive response ratio1.81.93.10.30.70.9-1.61.3-1.6-1.7-1.50.5-1.8-1.6-1.7-1.8-1.01.2
Condit. Reinf. active responses1.62.24.60.71.40.6-1.91.1-1.6-1.7-1.5-0.3-1.7-2.1-2.1-1.8-0.31.6
Condit. Reinf. inactive responses0.70.81.80.91.3-0.0-1.00.5-1.0-1.0-0.5-1.0-0.6-1.3-1.1-0.90.70.9
Condit. Reinf. lever presses0.30.41.6-1.0-0.41.3-0.31.0-0.2-0.2-0.4-0.1-0.4-0.5-0.3-0.4-0.90.4
Condit. Reinf. lever reinforcers received1.41.93.60.51.20.7-1.81.2-1.4-1.4-1.6-0.0-1.8-1.9-1.9-1.7-0.61.3
Conditioned reinforcement - actives1.01.03.5-0.4-0.31.2-1.10.6-1.2-1.2-0.5-0.8-0.5-1.2-1.4-1.00.51.9
Conditioned reinforcement - inactives1.21.35.3-0.5-1.42.3-0.61.0-1.1-1.1-0.70.5-0.8-1.3-1.3-1.1-0.81.4
Conditioned locomotion1.92.34.60.40.70.6-2.21.7-2.1-2.1-1.40.6-1.5-2.0-2.0-1.8-0.61.2
Patch foraging indifference point 0 sec0.40.73.1-0.7-1.00.50.10.90.20.2-0.51.8-0.70.30.50.1-1.7-0.3
Patch foraging indifference point AUC1.92.17.6-0.5-0.61.9-1.21.2-1.9-1.8-1.1-0.7-0.8-1.6-1.7-1.70.42.8
Delay disc. indifference point, 0s delay0.40.42.00.00.3-0.1-0.30.9-0.3-0.4-0.70.5-1.2-0.2-0.1-0.3-1.4-1.0
Delay disc. indifference point, 16s delay1.31.35.1-2.0-2.32.00.10.5-0.7-0.8-0.5-1.1-0.5-0.8-0.7-0.6-0.31.4
Delay disc. indifference point, 2s delay0.80.94.1-1.7-0.91.30.4-0.2-1.0-1.00.1-2.0-0.7-0.8-0.8-0.5-0.10.1
Delay disc. indifference point, 24s delay1.71.67.50.2-1.00.6-0.70.2-1.8-1.8-0.5-0.5-0.5-1.5-1.5-1.60.72.7
Delay disc. indifference point, 4s delay0.90.91.8-1.2-1.31.3-0.20.7-1.2-1.4-0.6-0.7-1.0-0.9-0.9-1.0-0.80.7
Delay disc. indifference point, 8s delay1.21.26.6-1.5-2.12.60.40.0-0.6-0.6-0.1-0.9-0.1-0.5-0.4-0.7-0.21.5
Indifference point function ln k1.21.76.61.41.6-2.60.5-1.11.41.41.00.20.51.31.21.20.2-2.0
Indifference point function log k1.21.76.61.41.6-2.60.5-1.11.41.41.00.20.51.31.21.20.2-2.0
Patch foraging total patch changes 0 sec0.50.72.9-1.1-1.40.90.30.80.20.3-0.31.5-0.50.40.70.2-1.7-0.4
Patch foraging total patch changes 12 sec0.70.92.1-0.10.10.7-1.11.4-0.9-0.8-1.40.6-1.4-0.9-0.8-1.0-0.80.8
Patch foraging total patch changes 18 sec2.12.74.6-0.2-0.61.7-1.42.2-1.8-1.7-2.01.7-2.2-1.7-1.4-1.6-1.91.2
Patch foraging total patch changes 24 sec0.40.52.2-0.4-0.81.5-0.30.6-0.5-0.5-0.40.2-0.8-0.4-0.6-0.8-0.40.9
Patch foraging total patch changes 6 sec1.11.62.6-0.8-0.91.5-0.91.6-1.6-1.6-1.11.5-1.3-1.3-1.0-1.4-0.91.4
Patch foraging time to switch 0 sec0.30.53.70.40.6-0.4-0.20.70.50.5-0.70.5-0.70.10.20.5-0.8-1.9
Patch foraging water rate 0 sec0.20.31.4-0.5-0.80.5-0.10.2-0.3-0.2-0.21.20.10.1-0.1-0.7-0.71.1
Patch foraging water rate 12 sec0.61.02.2-0.8-0.8-0.81.3-1.51.01.01.30.40.71.41.11.00.2-0.7
Patch foraging water rate 18 sec0.20.31.6-0.9-0.8-0.30.2-0.60.0-0.10.21.3-0.10.3-0.1-0.2-0.30.9
Patch foraging water rate 24 sec0.40.52.50.80.6-1.60.0-0.10.40.50.11.40.20.90.60.3-0.4-0.5
Patch foraging water rate 6 sec0.71.01.9-1.2-1.0-0.11.1-0.81.41.40.9-0.31.21.41.40.90.30.2
Seeking ratio, delayed vs. immediate footshock0.50.61.2-1.0-1.10.31.0-0.90.70.70.7-0.50.90.70.80.90.2-0.7
Distance traveled before self-admin0.50.52.6-1.1-0.81.6-0.20.9-0.3-0.4-0.9-0.2-0.6-0.3-0.3-0.1-0.9-0.5
Distance traveled after self-admin2.32.65.30.1-0.00.5-1.92.3-1.5-1.5-2.22.2-2.0-1.5-1.5-1.6-1.90.9
Extensor digitorum longus weight0.51.97.5-2.7-2.10.81.7-0.51.21.11.0-1.10.91.11.21.5-0.7-1.5
Bone: elastic displacement0.20.21.80.70.2-1.4-0.4-0.20.20.2-0.60.3-0.1-0.1-0.3-0.1-0.20.2
Bone: elastic work1.72.15.91.11.3-1.7-1.92.0-0.9-0.9-2.41.6-1.5-0.8-1.2-0.9-1.9-0.6
Bone: endosteal estimation1.12.35.31.71.7-1.8-2.02.3-1.2-1.2-1.71.8-1.7-1.0-1.1-1.0-1.2-0.1
Bone: endosteal perimeter0.91.97.31.82.2-2.7-1.71.8-0.6-0.6-1.21.2-1.2-0.4-0.6-0.4-0.6-0.9
Epididymis fat weight1.02.311.73.23.4-2.9-1.2-0.5-0.2-0.20.4-0.20.1-0.4-0.2-0.21.6-0.3
Delta time in closed arm before/after self-admin0.90.92.00.81.40.4-1.31.0-1.0-0.9-0.9-0.6-0.4-1.2-1.1-0.90.40.9
Delta time in open arm before/after self-admin0.30.31.1-0.9-1.10.40.7-0.40.30.30.40.4-0.10.50.40.5-0.6-0.6
Diff in mean of infusions in LGA sessions0.60.71.7-0.00.30.8-0.4-0.3-1.3-1.2-0.10.1-0.6-1.1-1.1-1.20.11.3
Delay discount exponential model param1.21.34.61.72.2-2.1-0.4-0.00.91.00.11.60.30.70.60.80.2-1.3
Extinction: sum of active levers before priming0.30.31.4-1.0-0.21.00.2-0.4-0.4-0.30.2-1.2-0.2-0.6-0.5-0.30.40.2
Active lever presses in extinction session 60.10.10.40.30.40.1-0.30.1-0.3-0.2-0.30.2-0.6-0.6-0.6-0.4-0.1-0.1
Bone: final force1.62.55.40.81.2-0.0-1.92.3-2.3-2.3-1.70.9-1.7-1.6-1.7-1.6-1.10.4
Bone: final moment1.83.06.20.91.30.0-2.12.5-2.4-2.4-1.81.2-1.9-1.8-1.8-1.8-1.30.5
Food consumed during 24 hour testing period1.31.52.41.51.5-0.2-1.51.4-1.4-1.4-1.41.0-1.5-1.2-1.2-1.2-0.50.2
Glucose0.30.41.80.30.3-0.30.5-0.00.70.8-0.21.2-0.50.50.50.3-1.3-1.0
Heart weight0.60.95.41.91.6-1.1-0.2-0.0-0.0-0.00.32.3-0.2-0.00.1-0.3-0.3-0.6
Delay discount hyperbolic model param1.21.34.21.82.1-2.0-0.4-0.11.01.10.21.60.50.70.60.80.3-1.1
Intermittent access intake day 1-15 change0.30.30.9-0.9-0.90.60.5-0.20.60.60.3-0.20.70.40.20.40.20.6
Intermittent access intake escalation0.30.30.9-0.9-1.00.70.6-0.30.70.70.4-0.30.70.40.30.50.20.4
Intermittent access intake escalation 20.20.20.3-0.5-0.60.50.5-0.30.60.60.30.20.30.30.10.3-0.00.2
Intermitt. access day 1 inactive lever presses1.21.33.90.4-0.70.6-1.11.9-0.7-0.7-1.51.5-1.6-0.7-0.9-0.9-2.00.1
Intermitt. access day 15 inactive lever presses1.31.42.60.80.00.8-1.51.2-1.4-1.3-1.11.0-1.1-1.5-1.5-1.5-0.51.6
Intermitt. access escalation Index0.30.31.3-0.3-0.70.41.1-0.80.20.20.6-0.40.40.10.70.50.5-0.3
Intermittent access day 1 total infusions1.82.14.10.50.50.6-2.02.0-1.8-1.8-1.80.7-1.6-1.8-1.6-1.5-1.00.7
Intermittent access day 15 total infusions1.11.22.5-0.4-0.51.1-1.41.6-1.1-1.1-1.30.7-0.9-1.3-1.3-1.1-0.91.2
Intermittent access terminal intake (last 3 days)0.50.61.2-0.2-0.30.9-1.01.0-0.8-0.8-0.80.4-0.4-1.1-1.0-0.7-0.30.9
Intermittent access total infusions1.82.03.90.10.31.2-1.92.0-1.7-1.7-1.70.7-1.3-1.9-1.7-1.4-0.90.8
Intermittent access day 1 locomotion1.41.53.00.40.30.8-1.61.7-1.4-1.3-1.41.2-1.2-1.4-1.4-1.2-1.20.3
Intermittent access day 15 total locomotion0.91.02.11.00.90.6-1.41.0-1.2-1.2-0.60.7-0.5-1.4-1.3-1.1-0.00.8
Intermittent access total locomotion2.52.95.71.51.50.8-2.42.2-1.8-1.8-1.71.8-1.4-2.0-1.9-1.7-1.01.0
Intermittent access standard deviation1.51.66.1-0.1-0.00.5-1.82.5-0.5-0.6-2.11.4-1.4-0.8-1.2-0.8-1.80.0
Left kidney weight3.59.739.16.26.3-4.0-3.91.8-2.5-2.4-1.40.9-1.7-2.2-2.2-2.41.00.7
Right kidney weight4.612.840.86.36.4-4.0-4.62.7-3.1-3.1-2.52.4-2.6-2.7-2.9-3.3-0.21.4
Cocaine induced anxiety0.40.41.81.31.0-0.90.3-0.5-0.1-0.20.20.20.5-0.10.10.30.1-1.3
Post-drug Anxiety0.40.41.91.40.7-1.3-0.2-0.3-0.1-0.30.11.20.2-0.2-0.0-0.2-0.1-0.4
Baseline Anxiety0.20.31.4-0.3-0.70.60.2-0.60.10.20.60.50.2-0.0-0.0-0.30.41.2
Tail length0.10.31.30.5-0.1-0.00.50.00.70.80.61.10.30.50.50.3-0.5-0.1
Length with tail0.62.310.03.22.3-2.3-1.81.4-0.6-0.6-0.52.0-0.5-0.8-1.0-1.1-0.11.0
Length without tail2.04.313.63.73.2-2.3-2.81.6-1.6-1.6-1.21.4-0.9-1.8-1.9-2.10.51.9
Times rat made contact with spout0.60.72.60.1-0.20.8-0.60.7-1.3-1.4-0.1-0.10.5-0.8-0.9-1.20.31.6
Lifetime Intake2.52.95.60.50.81.1-2.32.4-2.1-2.1-2.20.9-1.7-2.2-1.9-1.8-1.20.7
Liver weight, left0.50.73.71.61.2-1.9-0.40.70.40.5-0.4-0.10.30.70.60.70.8-0.7
Liver weight, right1.62.77.92.72.7-2.80.1-0.91.41.41.0-0.81.51.11.31.31.7-1.3
Locomotor activity0.60.94.71.52.2-1.6-1.10.4-0.4-0.5-0.71.1-0.3-0.4-0.3-0.20.1-0.2
Locomotor testing distance0.10.20.70.00.10.10.4-0.50.20.20.5-0.20.80.40.60.50.60.0
Locomotor testing rearing0.30.52.81.41.7-1.1-0.6-0.2-0.3-0.2-0.50.2-0.1-0.2-0.10.00.5-0.6
Locomotion in novel chamber4.25.28.0-2.1-2.30.72.8-2.52.62.62.7-1.52.72.42.82.51.6-0.6
Locomotion in novel chamber post-restriction0.70.92.8-1.5-0.51.10.9-0.50.60.70.8-1.70.90.70.91.00.6-0.6
Fecal boli incidents, locomotor time 12.12.36.40.0-0.11.6-1.62.5-1.5-1.4-1.91.5-1.6-1.5-1.4-1.5-1.31.3
Change in fecal boli incidents, locomotor task1.11.04.81.10.9-1.1-0.0-1.4-0.2-0.21.2-1.20.9-0.00.10.02.21.2
Time >=10cm from walls, locomotor time 11.21.22.40.80.6-0.5-1.61.5-1.2-1.0-1.41.2-1.3-1.2-1.0-1.0-1.10.3
Bouts of movement, locomotor time 10.50.62.21.01.5-0.5-1.00.1-0.7-0.8-0.3-0.5-0.4-0.7-0.8-0.80.60.7
Total resting periods, locomotor time 10.60.61.40.81.1-0.0-1.20.5-0.9-0.9-0.7-0.2-0.7-0.9-1.1-0.90.10.6
Rest time, locomotor task time 11.11.32.01.31.10.6-1.31.1-1.2-1.1-1.40.8-1.4-1.2-1.4-1.2-0.60.5
Distance moved, locomotor task time 10.91.02.40.1-0.1-1.51.0-1.31.11.01.3-0.41.11.11.21.00.5-1.0
Vertical activity count, locomotor time 10.30.31.70.70.1-0.70.4-0.50.50.30.61.30.50.50.60.0-0.3-0.1
Time >=10cm from walls, locomotor time 20.30.31.60.60.0-0.3-0.60.5-0.5-0.4-0.91.3-0.5-0.5-0.3-0.3-0.80.2
Bouts of movement, locomotor time 20.40.41.70.20.9-0.20.4-0.80.10.10.8-1.30.40.20.10.60.8-1.1
Total resting periods, locomotor time 20.20.21.50.10.80.10.1-0.3-0.3-0.30.4-1.20.0-0.2-0.30.20.5-0.7
Rest time, locomotor task time 20.50.61.60.2-0.20.6-0.70.7-1.0-0.7-0.8-0.1-0.9-0.9-1.3-1.0-0.11.2
Distance moved, locomotor task time 20.40.51.30.30.6-1.10.4-0.70.90.70.5-0.10.40.80.90.7-0.1-1.0
Vertical activity count, locomotor time 20.40.41.81.31.2-0.6-0.40.3-0.0-0.2-0.11.3-0.10.00.1-0.3-0.6-0.1
Light reinforcement 10.00.10.2-0.4-0.2-0.20.0-0.1-0.2-0.30.10.4-0.1-0.0-0.30.1-0.3-0.3
Light reinforcement 20.71.03.10.20.7-1.40.7-0.51.11.10.5-0.81.01.11.01.40.3-1.7
Bone: marrow area1.12.45.11.81.7-1.9-2.02.3-1.2-1.2-1.71.8-1.7-1.1-1.1-1.0-1.2-0.0
Bone: maximum diameter1.63.06.92.22.6-2.1-2.22.0-1.9-1.9-1.31.6-1.8-1.4-1.4-1.3-0.7-0.3
Bone: maximum force2.34.08.81.31.7-0.2-2.32.4-3.0-3.0-2.01.3-2.1-2.3-2.2-2.1-1.10.6
Bone: maximum moment2.64.59.61.41.9-0.2-2.52.6-3.1-3.1-2.21.6-2.2-2.5-2.3-2.2-1.30.7
Mean time between licks in bursts0.50.72.5-1.6-1.30.80.9-0.31.00.9-0.0-0.20.10.70.71.1-0.4-1.0
Mean num. licks in bursts0.30.41.60.90.7-1.2-0.70.6-0.6-0.5-0.10.20.0-0.2-0.6-0.6-0.30.3
Cd content in liver0.70.82.3-0.6-0.5-0.31.0-0.90.60.61.5-0.40.80.91.21.30.7-1.0
Co content in liver0.10.20.6-0.5-0.8-0.40.5-0.3-0.3-0.3-0.00.4-0.20.10.30.3-0.5-0.5
Cu content in liver2.02.59.1-3.0-3.01.22.2-1.50.80.81.2-1.11.01.01.41.3-0.2-0.7
Fe content in liver0.91.16.00.90.1-1.6-0.61.10.40.4-0.82.4-0.50.60.40.6-1.4-1.0
K content in liver0.20.20.7-0.5-0.50.3-0.20.50.20.2-0.90.2-0.6-0.2-0.3-0.2-0.8-0.1
Mg content in liver0.30.31.1-0.6-0.50.2-0.20.70.10.1-0.70.8-0.7-0.2-0.1-0.1-1.1-0.4
Mn content in liver0.40.42.4-0.20.4-0.50.4-0.40.40.40.3-1.50.80.70.50.51.10.0
Na content in liver0.40.41.2-1.1-1.10.60.5-0.30.60.60.20.80.50.50.70.6-0.5-0.3
Rb content in liver0.20.20.4-0.1-0.40.0-0.30.5-0.6-0.6-0.60.2-0.6-0.2-0.4-0.6-0.50.5
Se content in liver2.63.25.1-1.8-2.0-0.62.2-1.81.61.62.1-1.72.32.22.02.11.0-0.8
Sr content in liver2.62.47.2-2.7-2.21.71.8-1.31.11.11.5-2.01.51.21.31.10.8-0.0
Zn content in liver0.60.62.3-1.2-1.50.11.1-1.00.80.80.4-0.80.70.40.60.7-0.1-0.4
Bone: minimum diameter0.81.43.61.21.4-0.6-1.51.9-1.2-1.2-1.11.1-1.6-1.2-1.0-1.0-0.8-0.1
Time in familiar zone, hab. session 11.00.92.10.20.40.6-1.00.7-1.5-1.5-0.6-0.1-1.0-1.1-1.2-1.20.21.3
Time in novel zone, hab. session 10.90.92.80.50.2-1.60.5-0.01.21.2-0.01.10.70.70.91.1-0.5-1.7
Total zone transitions, hab. session 11.62.26.1-2.5-2.30.91.6-1.40.60.61.7-2.11.60.90.90.71.51.3
Total locomotion distance, hab. session 10.81.22.4-1.1-1.00.11.1-0.80.80.81.4-1.51.41.00.80.61.61.1
Locomotion velocity, hab. session 10.81.12.5-1.5-1.40.61.1-0.80.50.51.4-1.61.20.70.70.41.31.2
Time in familiar zone, hab. session 21.21.22.1-0.0-0.70.11.3-1.31.11.11.3-1.11.41.41.31.11.3-0.4
Time in novel zone, hab. session 21.21.22.10.10.7-0.3-1.31.3-1.0-1.0-1.31.2-1.5-1.4-1.3-1.2-1.20.5
Total zone transitions, hab. session 21.21.63.7-1.7-1.41.3-0.81.1-1.5-1.5-0.9-0.0-1.1-1.2-1.4-1.4-0.61.9
Total locomotion distance, hab. session 20.91.23.8-1.2-0.91.0-1.02.0-0.7-0.7-1.30.6-1.3-0.7-1.0-0.8-1.20.9
Locomotion velocity, hab. session 21.01.43.8-1.6-1.31.3-0.91.9-0.8-0.8-1.30.6-1.3-0.8-1.0-0.9-1.31.1
Novel to familiar place preference ratio0.70.86.30.71.2-2.50.1-1.1-0.0-0.00.90.60.7-0.00.30.40.6-0.2
Novelty place preference1.01.17.80.91.4-2.80.2-1.30.10.11.00.31.00.10.40.50.9-0.1
Time in novel zone, NPP test1.11.28.11.01.5-2.90.2-1.4-0.1-0.11.20.31.10.10.50.51.1-0.1
Total zone transitions, NPP test1.21.76.8-2.6-2.41.20.7-0.7-0.1-0.10.9-1.60.70.1-0.3-0.21.12.1
Total locomotion distance, NPP test0.40.62.6-1.5-1.10.6-0.30.7-0.3-0.30.0-0.5-0.4-0.3-0.7-0.70.31.6
Locomotion velocity, NPP test0.40.63.0-1.7-1.40.80.00.50.00.00.2-0.8-0.20.0-0.4-0.30.31.3
Intraocular pressure0.71.04.21.62.0-0.9-1.60.6-0.7-0.7-0.4-0.4-1.0-0.7-1.0-0.70.40.5
Delta distance traveled before/after self-admin1.81.93.41.71.2-1.4-1.71.1-1.4-1.3-1.11.8-1.0-1.2-1.3-1.6-0.31.7
Delta ambulatory time before/after self-admin2.62.84.81.41.1-1.2-2.21.6-1.8-1.8-1.52.1-1.5-1.7-1.7-2.0-0.72.0
Parametrial fat weight0.20.41.20.80.6-0.20.5-1.0-0.1-0.01.1-0.20.70.30.50.01.00.3
Pavlov. Cond. lever latency0.20.31.01.00.7-0.1-0.60.4-0.5-0.6-0.50.4-0.2-0.9-0.5-0.60.10.4
Pavlov. Cond. magazine entry latency0.40.52.2-1.5-0.91.1-0.20.5-0.5-0.5-0.9-0.4-0.7-0.2-0.6-0.2-0.50.3
Pavlov. Cond. change in total contacts0.80.92.6-1.4-0.91.6-0.40.9-1.1-1.1-0.90.1-1.0-0.7-0.7-0.7-0.70.7
Pavlov. Cond. index score0.20.30.6-0.7-0.20.5-0.60.6-0.5-0.4-0.8-0.1-0.8-0.3-0.7-0.5-0.50.3
Pavlov. Cond. latency score0.10.10.5-0.7-0.20.4-0.30.5-0.2-0.1-0.60.0-0.50.0-0.4-0.2-0.50.0
Pavlov. Cond. lever contacts0.10.21.0-1.0-0.60.50.10.30.30.4-0.2-0.1-0.40.40.00.1-0.6-0.1
Pavlov. Cond. magazine entry number0.20.30.80.90.5-0.90.3-0.30.50.40.50.70.30.20.60.3-0.0-0.6
Pavlov. Cond. intertrial magazine entries0.40.51.6-0.9-1.01.00.2-0.1-0.7-0.60.50.9-0.2-0.7-0.3-0.9-0.31.3
Pavlov. Cond. lever-magazine prob. diff.0.10.20.8-0.9-0.30.5-0.30.3-0.4-0.3-0.5-0.4-0.5-0.1-0.5-0.3-0.30.3
Pavlov. Cond. response bias0.30.31.0-1.0-0.50.8-0.40.8-0.4-0.3-0.7-0.4-0.7-0.1-0.7-0.3-0.50.3
Pavlov. Cond. lever latency0.60.83.60.81.1-0.4-0.1-1.2-0.8-0.80.3-1.30.4-0.5-0.3-0.41.90.7
Pavlov. Cond. magazine entry latency1.31.44.6-2.1-1.91.8-0.11.2-0.3-0.4-1.01.1-1.0-0.6-0.6-0.6-2.00.5
Pavlov. Cond. change in total contacts2.33.28.50.10.10.5-1.92.5-1.1-1.1-2.42.9-2.5-1.4-1.7-1.5-2.90.4
Pavlov. Cond. index score0.81.04.1-1.5-1.41.4-0.31.40.10.1-0.91.2-0.8-0.0-0.4-0.3-2.00.2
Pavlov. Cond. latency score1.01.24.6-1.6-1.51.5-0.41.50.0-0.0-1.01.3-0.9-0.1-0.6-0.5-2.10.4
Pavlov. Cond. lever contacts0.50.72.8-0.9-0.90.40.30.80.80.9-0.11.1-0.00.70.50.5-1.7-0.8
Pavlov. Cond. magazine entry number0.50.62.01.31.1-1.20.2-0.80.20.30.7-0.90.60.20.50.51.4-0.5
Pavlov. Cond. intertrial magazine entries0.81.13.31.81.40.1-1.00.4-1.3-1.2-0.40.1-1.0-1.2-0.9-1.40.80.8
Pavlov. Cond. lever-magazine prob. diff.0.70.93.7-1.5-1.41.2-0.11.20.20.2-0.61.2-0.60.2-0.2-0.2-1.9-0.0
Pavlov. Cond. response bias0.60.83.9-1.1-1.00.7-0.21.40.10.1-0.81.2-0.8-0.1-0.2-0.1-2.0-0.4
Time in closed arm before self-admin1.41.65.8-1.7-2.41.10.80.60.60.5-0.51.9-0.50.70.60.6-2.1-1.4
Time in closed arm after self-admin0.80.81.81.30.7-0.1-1.01.3-0.8-0.8-1.11.3-0.8-0.8-0.8-0.8-0.7-0.1
Time in open arm before self-admin0.30.41.20.50.6-0.1-0.0-0.60.50.60.6-1.10.80.40.30.21.00.7
Time in open arm after self-admin1.41.62.5-0.8-0.80.31.5-1.51.51.51.6-0.71.31.61.51.40.4-0.9
Bone: periosteal estimation1.12.24.71.51.8-1.6-1.82.2-1.6-1.6-1.51.5-1.6-1.2-1.2-1.1-1.0-0.2
Bone: periosteal perimeter1.62.67.22.12.7-2.4-2.01.9-1.2-1.2-1.41.5-1.7-1.0-1.0-0.9-0.7-0.6
Bone: post-yield work1.72.37.00.10.21.0-1.21.2-2.6-2.6-0.60.8-1.1-2.5-1.7-1.7-0.21.2
Progressive ratio test 1 active lever presses2.02.14.0-0.0-0.11.6-1.71.7-2.0-2.0-1.50.3-1.2-1.9-1.8-1.5-0.81.0
Progressive ratio test 1 breakpoint1.31.42.90.1-0.21.5-1.41.3-1.7-1.7-1.10.2-0.8-1.6-1.5-1.2-0.51.1
Progressive ratio test 1 inactive lever presses0.91.02.7-0.4-0.31.6-0.81.5-0.9-0.9-1.10.8-1.4-0.8-0.8-0.5-1.6-0.6
Progressive ratio test 2 active lever presses1.41.53.50.50.21.6-1.31.1-1.6-1.5-0.8-0.2-0.7-1.5-1.5-1.50.21.9
Progressive ratio test 2 breakpoint1.51.72.90.50.31.5-1.51.4-1.7-1.7-1.10.1-1.1-1.6-1.7-1.6-0.01.7
Progressive ratio test 2 inactive lever presses0.91.14.9-0.6-1.02.2-0.61.1-1.0-1.0-0.7-0.1-0.7-1.2-1.1-0.9-0.51.2
Incentive Sensitization - Responses0.20.20.80.50.10.50.1-0.30.20.20.5-0.50.30.30.1-0.10.90.8
Incentive Sensitization - Breakpoint0.20.20.90.70.30.4-0.0-0.20.00.10.4-0.60.20.1-0.1-0.31.00.9
Sum of active levers in priming session hrs 5-60.20.20.7-0.8-0.60.60.3-0.00.20.4-0.30.3-0.40.10.10.3-0.8-0.5
Progressive ratio0.40.51.5-0.5-0.60.8-0.30.8-0.3-0.3-1.01.2-0.4-0.5-0.3-0.5-1.20.1
Food seeking constrained by brief footshock0.30.41.10.50.6-0.4-0.60.0-1.1-1.0-0.2-0.3-0.2-1.0-1.0-0.60.30.2
Seeking ratio, punishment vs. effort0.20.20.70.50.6-0.5-0.3-0.3-0.6-0.60.4-0.8-0.2-0.3-0.6-0.10.80.1
Retroperitoneal fat weight1.44.726.84.65.2-3.9-1.5-0.1-0.8-0.8-0.30.6-0.2-0.6-0.2-0.51.5-0.5
Reaction time number correct1.11.64.4-0.5-0.6-0.21.3-0.91.21.31.5-2.11.81.41.11.21.70.0
Reaction time mean minus median0.10.10.3-0.1-0.0-0.10.10.10.50.4-0.10.5-0.20.10.10.2-0.4-0.5
Reaction time mean minus median AUC0.20.20.70.70.8-0.6-0.00.00.70.70.10.2-0.20.40.30.3-0.2-0.8
Reaction time num false alarms0.20.30.8-0.2-0.0-0.60.4-0.80.90.8-0.00.70.10.70.60.6-0.4-0.7
Reaction time num false alarms AUC0.20.30.8-0.3-0.2-0.40.5-0.90.90.80.20.40.30.70.50.6-0.2-0.4
Reaction time trials correct on left1.11.64.4-0.5-0.6-0.21.3-0.91.21.31.5-2.11.81.41.11.21.70.0
Reaction time trials on left1.11.64.6-0.6-0.6-0.21.3-0.91.31.31.5-2.21.81.41.21.21.70.1
Reaction time mean0.20.30.7-0.2-0.5-0.30.5-0.60.80.70.10.7-0.10.40.50.5-0.5-0.9
Reaction time mean AUC0.10.20.4-0.3-0.4-0.30.4-0.60.60.60.20.30.00.30.40.4-0.3-0.6
Median of all reaction times0.20.30.7-0.5-0.7-0.20.6-0.70.70.6-0.00.5-0.00.40.50.6-0.5-0.8
Reaction time omissions0.30.31.7-1.3-1.20.30.30.60.50.5-0.0-0.9-0.20.00.10.3-0.1-0.3
Reaction time false alarm rate0.20.21.4-0.20.0-0.30.1-0.50.40.3-0.31.2-0.30.30.30.3-0.8-0.6
Reaction time premature initiation rate0.91.24.10.4-0.0-0.2-1.11.1-0.8-0.6-1.42.0-2.0-0.6-1.1-1.1-1.5-0.1
Reaction time premature initiations0.20.31.30.4-0.1-0.3-0.60.7-0.2-0.1-0.70.8-1.1-0.0-0.6-0.7-0.50.1
Std. dev. reaction times0.10.20.90.70.4-0.7-0.20.00.40.4-0.21.0-0.50.00.10.0-0.5-0.4
Reaction time trials completed1.11.64.6-0.6-0.6-0.21.3-0.91.31.31.5-2.21.81.41.21.21.70.1
Reaction time trials AUC0.91.23.6-0.3-0.3-0.31.1-0.81.11.11.3-1.91.61.21.01.01.60.0
Run reversals in cocaine runway, females1.00.92.70.3-0.3-1.11.2-1.60.80.71.6-0.30.91.10.70.91.0-0.1
Run reversals in cocaine runway, males1.11.14.40.00.40.2-1.00.4-1.2-1.2-0.4-1.4-0.1-1.3-1.3-1.30.72.1
Latency to leave start box in cocaine runway0.70.82.90.01.1-1.70.2-0.20.90.80.3-0.80.40.70.90.90.4-1.6
Latency to leave start box in cocaine runway, F0.50.61.7-1.3-0.1-0.70.4-0.10.80.70.3-0.90.30.61.01.0-0.2-1.3
Latency to leave start box in cocaine runway, M0.90.93.81.51.7-2.00.0-0.30.60.60.2-0.20.30.50.40.50.9-1.1
Std. dev. time between licks in bursts0.50.61.7-0.9-1.20.8-0.31.2-0.1-0.3-1.01.1-0.6-0.4-0.2-0.3-1.30.3
Total sessions with >9 infusions2.32.64.61.51.50.5-2.11.7-2.1-2.1-1.60.9-1.3-2.1-1.9-1.8-0.70.8
Short access day 1 total inactive lever presses3.84.27.40.10.11.2-2.52.7-2.4-2.4-2.42.2-2.0-2.3-2.2-2.3-2.21.3
Short access day 10 total inactive lever presses0.70.82.91.40.1-0.3-1.01.1-0.3-0.3-0.91.7-0.9-0.4-0.7-0.8-0.81.0
Short access day 1 total infusions1.41.43.10.81.20.8-1.61.8-1.3-1.3-1.51.2-1.1-1.2-0.9-1.2-1.10.3
Short access day 10 total infusions2.42.75.50.91.20.3-2.32.3-1.9-1.9-2.11.0-2.0-1.9-1.7-1.6-1.40.0
Short access total infusions3.33.76.81.31.80.5-2.62.5-2.3-2.3-2.41.5-2.0-2.3-1.9-1.9-1.40.2
Short access day 1 locomotion1.01.02.7-0.00.41.1-1.31.6-0.8-0.7-1.51.3-1.0-0.7-0.9-0.7-1.5-0.3
Short access day 10 total locomotion1.21.45.1-0.40.01.8-1.11.90.00.1-1.41.6-1.3-0.1-0.3-0.3-2.3-0.8
Short access total locomotion2.72.96.30.91.11.1-2.32.5-1.6-1.5-2.12.0-1.9-1.5-1.6-1.4-2.1-0.1
One hour access (0.3 mA shock)0.81.04.4-1.6-1.42.1-0.30.9-0.6-0.6-0.6-1.1-0.2-0.9-1.0-0.40.10.8
Compulsive drug intake0.90.93.8-0.7-1.51.11.0-1.00.10.00.9-0.90.90.10.2-0.11.31.9
One hour access (shock baseline)0.20.30.7-0.40.00.7-0.60.9-0.3-0.3-0.7-0.2-0.4-0.5-0.5-0.0-0.6-0.7
Social response proportion1.11.15.0-1.1-0.6-1.10.21.10.60.6-0.80.9-0.70.30.61.1-2.0-2.2
Social responses0.30.41.2-1.1-0.20.2-0.40.7-0.6-0.5-0.5-0.1-1.0-1.0-0.6-0.2-0.60.4
Social time0.81.15.0-2.2-2.01.60.20.60.0-0.0-0.70.2-1.1-0.1-0.3-0.0-1.7-0.1
Soleus weight0.61.76.10.1-0.52.0-1.21.0-0.9-1.0-1.20.1-1.3-1.2-1.7-1.9-0.52.5
Bone: stiffness1.52.34.71.11.4-0.1-1.71.9-2.2-2.2-1.61.9-1.6-1.5-1.3-1.4-1.2-0.1
Tibialis anterior weight0.62.010.7-3.3-2.82.61.4-0.60.1-0.00.4-1.2-0.1-0.10.10.1-0.9-0.0
Time to tail flick, vehicle, before self-admin0.40.41.40.60.6-0.3-0.7-0.0-0.6-0.6-0.20.4-0.3-0.8-0.8-1.00.51.2
Time to tail flick, vehicle, after self-admin0.30.30.8-0.5-0.9-0.40.7-0.80.70.70.90.10.40.70.50.40.20.2
Time to tail flick, test, before self-admin0.40.41.8-0.3-0.20.40.5-0.6-0.2-0.30.8-1.40.2-0.3-0.2-0.21.20.5
Time to tail flick, test, after self-admin0.70.71.4-1.0-1.20.61.1-1.10.80.71.2-0.21.20.70.60.90.5-0.2
Delta time to tail flick, vehicle, before/after SA0.40.41.4-1.0-1.20.50.50.20.50.50.00.3-0.10.60.40.6-1.1-0.9
Delta time to tail flick, test, before/after SA1.61.52.7-1.2-1.40.31.6-1.41.41.31.40.41.61.41.31.50.1-0.5
Tibia length0.71.83.91.51.5-0.6-1.71.2-2.0-2.0-0.7-0.1-1.4-1.8-1.5-1.40.01.1
Ambulatory time before self-admin0.40.43.0-1.2-1.11.70.40.30.00.0-0.2-0.50.10.10.10.2-0.3-0.1
Ambulatory time after self-admin1.41.52.9-0.8-0.60.5-1.51.7-1.2-1.2-1.51.6-1.1-1.1-1.1-1.2-1.41.4
Bone: tissue strength0.20.20.70.40.5-0.6-0.70.8-0.3-0.3-0.50.4-0.1-0.4-0.3-0.2-0.30.2
Total heroin consumption0.30.41.0-0.60.10.5-0.30.2-1.0-1.0-0.3-0.7-0.3-0.8-0.8-0.60.20.6
Bone: trabecular number0.20.41.2-0.00.2-0.50.6-0.60.60.60.7-0.51.10.80.80.60.6-0.4
Bone: trabecular spacing2.32.95.01.51.30.2-2.11.4-2.2-2.2-1.70.8-2.1-2.2-2.2-2.0-0.61.3
Bone: trabecular thickness1.11.34.0-0.7-0.5-0.11.4-0.61.41.41.0-0.31.32.01.71.30.1-1.3
Bone: trabecular tissue density0.91.23.6-1.5-1.90.41.5-1.30.70.70.60.90.51.21.21.1-1.0-0.9
Water consumed over 24 hours0.60.72.30.40.00.1-0.80.6-1.5-1.4-0.40.30.1-0.9-0.9-1.20.31.5
Number of responses in last shaping day1.41.43.3-1.2-0.41.7-0.91.8-1.1-1.2-1.60.2-1.3-1.2-1.0-0.7-1.8-0.6