Hub : Genes

Cacul1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio NM_001014248.2 0.03 0.02 3.8e-03 0.02 0.02 0.01 0.02 1.2e-03 6.3e-03 3.7e-02 2.3e-03
2 NAcc isoform ratio NM_001014248.2 0.06 0.04 1.1e-05 0.06 0.04 0.05 0.05 6.0e-07 6.2e-06 3.8e-06 1.8e-06
3 PL intron excision ratio chr1_259677583_259686255 0.02 0.02 9.7e-03 0.02 0.02 0.01 0.02 1.6e-03 5.5e-03 8.7e-03 3.9e-03
4 Brain isoform ratio NM_001014248.2 0.12 0.07 5.2e-08 0.09 0.09 0.08 0.09 1.5e-08 8.4e-09 3.0e-08 1.1e-08
5 Brain intron excision ratio chr1_259677583_259686255 0.12 0.06 3.4e-09 0.09 0.1 0.11 0.1 7.8e-09 8.5e-10 1.9e-10 2.5e-09
6 Liver isoform ratio NM_001014248.2 0.03 0.02 9.1e-03 0.01 0.02 0.01 0.01 6.0e-02 6.6e-03 5.8e-02 3.0e-02
7 Brain isoform ratio NM_001416001.1 0.09 0.05 9.8e-08 0.06 0.09 0.08 0.08 3.5e-06 1.4e-08 2.9e-08 3.4e-08
8 NAcc isoform ratio NM_001416001.1 0.04 0.03 1.1e-04 0.03 0.04 0.04 0.04 2.9e-04 2.4e-05 3.3e-05 3.0e-05
9 BLA isoform ratio NM_001014248.2 0.08 0.05 6.3e-03 0 0.02 0.01 0.01 2.1e-01 2.9e-02 9.3e-02 6.3e-02
10 Brain alternative TSS XM_039085812.1 0.03 0.02 9.8e-03 0.02 0.03 0.02 0.03 3.4e-03 1.0e-03 9.9e-03 1.3e-03
11 Brain alternative TSS NM_001014248.2 0.03 0.02 8.9e-03 0.02 0.03 0.03 0.03 2.9e-03 8.3e-04 9.9e-04 1.0e-03
12 NAcc gene expression Cacul1 0.15 0.07 1.9e-10 0.11 0.09 0.09 0.1 3.0e-12 8.9e-11 1.0e-10 4.0e-11
13 Adipose gene expression Cacul1 0.12 0.07 5.5e-10 0.07 0.08 0.1 0.09 2.1e-08 1.6e-09 6.0e-11 7.7e-10
14 Brain gene expression Cacul1 0.06 0.03 1.3e-05 0.01 0.04 0.04 0.03 1.4e-02 5.1e-05 9.6e-05 4.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density4.88.113.8-3.6-3.5-3.43.7-2.83.0-3.5-2.60.52.6-2.62.81.8-1.3
Area under the delay curve0.60.64.20.10.30.3-0.5-0.60.10.5-0.42.0-0.30.3-1.0-1.10.9
BMI with tail24.479.1152.9-12.4-11.8-11.711.2-10.410.2-9.9-9.46.66.1-6.15.61.20.2
BMI without tail17.836.863.4-7.7-8.0-8.07.4-7.27.0-6.7-6.84.74.5-4.54.21.8-0.5
Body weight23.096.2178.1-13.3-12.9-12.812.3-11.311.3-11.0-10.57.07.1-7.16.62.1-0.4
Weight adjusted by age3.53.98.9-2.5-3.0-2.92.4-2.32.3-2.0-2.31.51.1-1.10.90.40.3
Bone surface3.76.511.5-3.2-3.3-3.33.4-2.72.7-3.1-2.50.82.1-2.12.41.4-0.8
Bone volume5.49.217.2-4.1-4.2-4.04.0-3.33.3-3.5-3.01.52.3-2.32.41.2-0.5
Breakpoint value in progressive ratio session1.71.93.7-1.1-1.4-1.40.9-1.61.7-1.1-1.91.71.4-1.40.21.7-0.5
Number of licking bursts0.70.81.7-0.3-0.3-0.30.6-0.80.9-0.9-0.90.41.3-1.31.01.2-1.2
Context. condit. distance diff. score0.20.30.6-0.6-0.1-0.30.8-0.80.4-0.7-0.1-0.30.5-0.50.60.2-0.5
Locomotion velocity, session 10.90.92.41.61.11.2-1.01.3-1.20.91.0-1.1-0.60.60.1-0.3-0.4
Locomotion distance, session 12.22.84.31.71.91.8-1.71.6-2.01.82.1-1.0-1.81.8-1.4-1.60.9
Locomotion velocity, session 21.72.02.81.51.31.7-1.41.6-1.71.51.7-1.2-1.51.5-1.0-1.40.7
Locomotion distance, session 20.30.41.2-0.9-0.7-0.70.5-0.30.0-0.10.20.1-0.60.6-0.4-1.11.1
Locomotion velocity, session 31.61.93.51.71.91.4-1.71.7-1.61.51.6-1.0-1.01.0-1.1-0.30.2
Locomotion distance, session 30.80.91.71.11.00.9-1.01.3-1.21.01.2-1.1-0.80.8-0.5-0.20.1
Stereotopy head waving bouts, day 31.11.41.91.11.00.9-1.31.3-1.31.41.1-0.0-1.41.4-1.2-1.21.0
Stereotopy head waving duration, day 31.41.72.81.41.31.2-1.71.0-1.31.71.00.5-1.41.4-1.6-1.31.2
Locomotion velocity, session 70.10.10.2-0.20.20.00.3-0.40.3-0.3-0.00.00.3-0.30.10.0-0.2
Locomotion distance, session 70.70.82.3-1.4-1.2-1.51.4-0.80.8-1.1-0.4-0.40.5-0.50.70.4-0.1
Stereotopy head waving bouts, day 70.50.52.21.11.11.0-0.9-0.5-0.20.6-0.21.50.0-0.0-0.5-0.3-0.0
Stereotopy head waving duration, day 70.81.03.01.41.71.6-1.3-0.4-0.30.9-0.11.70.0-0.1-0.7-0.4-0.1
Locomotion velocity, session 80.50.62.80.91.00.4-0.40.8-0.80.30.9-1.70.0-0.00.50.5-1.0
Locomotion distance, session 80.20.32.4-0.30.0-0.40.60.2-0.2-0.40.6-1.60.0-0.00.70.2-0.5
Degree of sensitization distance2.62.64.9-2.1-2.1-2.22.1-1.81.8-1.9-1.50.41.3-1.31.30.7-0.4
Degree of sensitization stereotypy0.50.63.90.40.70.7-0.3-1.30.50.1-0.82.00.5-0.5-0.3-0.2-0.1
Conditioned locomotion0.10.20.50.60.60.5-0.70.1-0.40.50.20.2-0.20.2-0.5-0.10.1
Cocaine response after cond. corrected3.53.97.51.21.41.6-1.62.7-2.41.92.7-2.4-2.32.3-1.5-1.81.3
Cocaine response after cond. not corrected3.53.98.91.81.71.8-1.83.0-2.41.92.6-2.8-1.81.8-1.0-0.80.5
Cocaine response before conditioning1.21.46.60.70.1-0.10.10.00.6-0.6-0.9-0.61.5-1.51.52.6-2.1
Saline control response1.11.52.91.31.01.3-1.71.0-1.21.60.90.3-1.21.2-1.5-0.91.0
Bone: connectivity density1.11.73.2-1.5-1.4-1.41.8-1.21.2-1.7-0.9-0.41.3-1.31.51.2-1.0
Bone: cortical apparent density7.09.213.93.33.73.7-3.53.6-3.63.33.6-2.4-2.62.6-2.3-1.70.9
Bone: cortical area9.714.625.4-5.0-5.0-4.84.6-4.74.5-4.2-4.23.02.8-2.82.31.2-0.1
Bone: cortical porosity1.71.92.8-1.5-1.6-1.71.5-1.21.6-1.6-1.60.81.4-1.41.11.2-0.7
Bone: cortical porosity2.62.94.2-1.8-2.0-2.11.9-1.72.0-1.9-2.01.31.6-1.61.31.3-0.6
Bone: cortical thickness4.98.116.7-4.1-4.0-3.83.4-3.43.3-3.0-3.02.41.7-1.71.20.40.6
Bone: cortical thickness2.52.96.2-2.5-2.3-2.41.5-1.91.7-1.1-1.62.50.1-0.1-0.6-0.91.8
Bone: cortical tissue density7.59.915.13.53.93.9-3.63.7-3.73.43.8-2.5-2.62.6-2.3-1.70.8
Condit. Reinf. active minus inactive responses0.50.63.8-0.10.50.30.60.5-0.3-0.50.7-1.90.4-0.41.10.4-1.2
Condit. Reinf. active-inactive response ratio0.60.62.90.90.90.7-0.20.9-0.80.20.9-1.7-0.10.10.70.3-0.9
Condit. Reinf. active responses1.72.15.0-2.1-1.1-1.02.2-1.01.2-2.0-0.6-1.11.4-1.41.90.6-1.2
Condit. Reinf. inactive responses3.54.210.0-3.2-2.3-1.92.9-2.02.3-2.7-1.70.21.9-1.91.90.9-0.8
Incentive salience index mean0.40.53.5-0.60.1-0.10.90.3-0.1-0.70.6-1.90.3-0.31.00.1-0.8
Condit. Reinf. lever presses0.20.31.6-0.8-0.2-0.20.80.1-0.0-0.60.5-1.30.1-0.10.5-0.1-0.2
Condit. Reinf. active minus inactive responses2.53.14.7-1.5-1.8-1.51.9-1.92.0-2.0-2.21.01.9-1.92.01.4-1.2
Condit. Reinf. active-inactive response ratio2.12.24.4-1.2-1.7-1.61.5-1.71.8-1.5-2.11.61.4-1.41.30.9-0.6
Condit. Reinf. active responses3.75.17.3-2.3-2.2-1.82.6-2.72.6-2.7-2.61.32.5-2.52.31.4-1.5
Condit. Reinf. inactive responses1.82.33.5-1.6-1.3-1.01.9-1.81.7-1.9-1.50.51.7-1.71.70.8-1.2
Condit. Reinf. lever presses2.33.15.0-2.2-1.9-1.82.0-2.22.1-2.0-1.91.11.8-1.71.40.9-0.7
Condit. Reinf. lever reinforcers received2.73.85.4-1.9-1.7-1.42.2-2.22.2-2.3-2.10.82.3-2.32.21.4-1.6
Conditioned reinforcement - actives3.83.88.12.82.12.1-2.12.7-2.52.02.1-2.3-1.41.4-0.4-0.2-0.4
Conditioned reinforcement - inactives0.20.20.50.30.70.7-0.50.5-0.30.30.3-0.30.2-0.2-0.30.5-0.4
Conditioned locomotion2.22.66.62.11.51.5-1.62.4-2.11.51.9-2.6-1.11.10.10.1-0.6
Patch foraging indifference point 0 sec4.26.712.9-3.6-3.3-3.22.9-3.43.1-2.6-2.92.71.9-1.90.90.50.3
Patch foraging indifference point AUC0.20.21.5-0.40.10.1-0.3-0.50.50.1-0.41.20.3-0.3-0.80.20.3
Delay disc. indifference point, 0s delay0.30.30.8-0.7-0.7-0.70.3-0.30.3-0.1-0.40.9-0.30.3-0.3-0.80.9
Delay disc. indifference point, 16s delay0.40.42.80.50.40.4-0.5-0.8-0.00.4-0.41.7-0.20.2-0.4-0.90.4
Delay disc. indifference point, 2s delay0.91.02.70.40.80.8-0.90.4-0.71.00.60.9-1.11.1-1.4-1.61.3
Delay disc. indifference point, 24s delay0.40.43.00.20.10.1-0.4-0.50.20.3-0.51.7-0.10.1-0.8-0.60.7
Delay disc. indifference point, 4s delay0.40.52.80.30.30.3-0.6-0.2-0.00.5-0.31.7-0.40.3-0.9-1.00.8
Delay disc. indifference point, 8s delay0.60.72.00.50.70.7-1.00.0-0.40.90.21.4-0.60.5-1.3-1.00.9
Indifference point function ln k0.20.31.0-0.9-0.8-1.00.9-0.20.2-0.5-0.0-0.5-0.20.20.5-0.70.4
Indifference point function log k0.20.31.0-0.9-0.8-1.00.9-0.20.2-0.5-0.0-0.5-0.20.20.5-0.70.4
Patch foraging total patch changes 0 sec4.98.015.4-3.9-3.7-3.53.1-3.63.4-2.9-3.23.02.0-2.01.00.50.4
Patch foraging total patch changes 12 sec3.64.78.2-2.9-2.7-2.52.2-2.72.6-2.2-2.52.21.9-1.90.91.0-0.1
Patch foraging total patch changes 18 sec2.33.05.1-2.3-2.2-1.81.7-2.12.1-1.8-2.01.61.6-1.60.81.0-0.3
Patch foraging total patch changes 24 sec0.81.02.2-1.1-0.5-0.40.4-1.41.3-0.8-1.11.51.2-1.2-0.11.1-0.3
Patch foraging total patch changes 6 sec3.85.610.3-3.2-2.7-2.42.2-3.03.0-2.3-2.82.72.2-2.20.51.4-0.1
Patch foraging time to switch 0 sec0.91.33.31.81.21.5-1.21.7-1.41.11.1-1.4-0.60.6-0.10.2-0.6
Patch foraging water rate 0 sec1.93.07.6-2.8-2.1-2.22.0-2.32.0-1.7-1.72.00.8-0.80.2-0.60.9
Patch foraging water rate 12 sec2.23.45.5-2.3-2.2-2.32.1-2.32.2-1.9-2.21.91.4-1.41.10.5-0.0
Patch foraging water rate 18 sec0.60.82.0-1.4-1.2-1.30.7-0.80.5-0.3-0.40.9-0.50.5-0.4-1.21.4
Patch foraging water rate 24 sec2.33.28.5-2.9-2.6-2.61.9-1.81.5-1.2-1.32.0-0.10.1-0.3-1.71.9
Patch foraging water rate 6 sec0.91.43.6-1.9-1.9-1.71.4-1.21.1-1.0-1.01.00.1-0.10.1-0.71.0
Seeking ratio, delayed vs. immediate footshock4.04.710.02.33.23.1-2.02.6-2.51.82.9-2.8-1.11.1-0.7-0.2-0.6
Distance traveled before self-admin3.33.65.71.71.31.3-2.11.9-1.92.21.8-0.0-2.32.3-2.4-1.92.0
Distance traveled after self-admin2.32.63.71.71.61.6-1.91.8-1.81.91.8-0.8-1.71.7-1.8-0.81.0
Extensor digitorum longus weight1.76.813.2-3.3-3.6-3.53.2-2.83.0-2.9-2.81.42.0-2.01.91.2-0.4
Bone: elastic displacement0.50.61.00.80.10.2-1.00.9-0.61.00.20.6-0.90.9-1.0-0.71.0
Bone: elastic work0.91.24.5-0.7-1.2-1.50.2-0.30.20.3-0.51.7-1.01.0-1.2-1.22.1
Bone: endosteal estimation1.73.77.4-2.4-2.7-2.62.5-2.12.1-2.2-2.11.31.3-1.31.50.6-0.1
Bone: endosteal perimeter2.04.27.9-2.4-2.6-2.32.3-2.82.3-2.0-2.52.51.3-1.31.10.00.3
Epididymis fat weight33.979.1139.8-11.8-11.0-11.011.0-10.510.4-10.1-9.56.07.2-7.26.43.1-1.4
Delta time in closed arm before/after self-admin0.20.21.8-0.2-0.2-0.20.30.6-0.4-0.10.6-1.4-0.30.40.3-0.0-0.0
Delta time in open arm before/after self-admin3.13.08.8-0.4-0.7-0.71.2-1.41.6-1.6-1.7-0.12.2-2.22.13.0-2.4
Diff in mean of infusions in LGA sessions0.30.41.60.2-0.3-0.3-0.2-0.60.6-0.1-1.01.30.6-0.6-0.41.0-0.2
Delay discount exponential model param0.70.74.7-0.2-0.3-0.30.70.6-0.0-0.60.3-2.20.4-0.41.21.1-1.0
Extinction: sum of active levers before priming0.40.41.0-0.30.30.30.3-0.60.7-0.6-0.60.41.0-1.00.41.0-0.8
Active lever presses in extinction session 60.80.83.7-0.8-0.9-0.90.2-1.01.0-0.3-1.11.90.3-0.3-1.00.10.8
Bone: final force5.58.918.7-4.3-4.2-4.13.8-3.53.3-3.1-3.12.61.6-1.61.4-0.10.8
Bone: final moment6.210.020.2-4.5-4.5-4.54.0-3.63.5-3.4-3.32.61.8-1.81.70.30.6
Food consumed during 24 hour testing period0.50.52.1-0.7-1.2-1.40.9-0.40.7-0.8-0.6-0.20.4-0.40.70.5-0.1
Glucose5.17.714.3-2.5-2.9-2.92.7-3.83.4-2.8-3.83.52.5-2.51.81.3-0.6
Heart weight6.38.917.6-3.7-4.0-4.23.6-3.73.4-3.1-3.52.81.9-1.91.80.30.2
Delay discount hyperbolic model param0.80.84.3-0.3-0.5-0.50.80.40.1-0.70.2-2.10.5-0.51.31.3-1.1
Intermittent access intake day 1-15 change0.10.10.70.4-0.1-0.1-0.3-0.00.20.1-0.40.30.2-0.20.10.8-0.2
Intermittent access intake escalation0.10.10.30.40.10.1-0.50.5-0.40.50.2-0.1-0.50.5-0.30.10.3
Intermittent access intake escalation 20.20.10.6-0.1-0.6-0.60.2-0.10.2-0.2-0.5-0.20.1-0.10.50.8-0.3
Intermitt. access day 1 inactive lever presses1.11.12.1-1.2-0.8-0.80.8-1.31.5-1.0-1.31.11.3-1.30.21.2-0.4
Intermitt. access day 15 inactive lever presses0.60.62.8-0.6-0.7-0.70.0-1.00.70.0-0.81.7-0.10.1-1.0-0.21.1
Intermitt. access escalation Index0.10.10.4-0.2-0.3-0.30.20.0-0.0-0.20.0-0.60.2-0.20.70.3-0.4
Intermittent access day 1 total infusions0.40.50.80.90.90.9-0.90.8-0.80.70.7-0.6-0.40.4-0.5-0.0-0.1
Intermittent access day 15 total infusions0.50.61.21.00.70.8-1.11.1-0.91.00.7-0.4-0.70.7-0.60.00.2
Intermittent access terminal intake (last 3 days)0.20.20.60.60.60.6-0.80.7-0.50.70.4-0.1-0.40.4-0.40.10.1
Intermittent access total infusions0.80.81.51.21.21.2-1.21.2-1.11.00.9-0.7-0.60.6-0.5-0.1-0.1
Intermittent access day 1 locomotion2.12.23.71.21.81.8-1.61.8-1.81.51.9-1.0-1.31.3-1.3-1.20.5
Intermittent access day 15 total locomotion0.10.20.5-0.20.10.10.1-0.40.4-0.3-0.50.70.5-0.5-0.00.5-0.3
Intermittent access total locomotion1.01.11.90.81.21.2-1.11.4-1.31.11.4-0.9-1.01.0-0.8-0.80.4
Intermittent access standard deviation0.30.31.10.80.50.5-0.50.2-0.20.2-0.2-0.20.4-0.40.71.0-0.9
Left kidney weight6.919.547.3-6.7-6.8-6.95.9-4.34.6-4.8-4.12.11.9-1.92.7-0.21.3
Right kidney weight6.718.748.5-7.0-6.7-6.65.8-4.24.5-4.7-3.82.01.9-1.82.3-0.31.4
Cocaine induced anxiety3.03.46.72.62.02.0-2.12.2-2.32.02.1-2.3-1.41.4-0.50.0-0.2
Post-drug Anxiety0.50.51.21.01.11.1-0.70.7-0.80.60.8-1.0-0.30.3-0.10.2-0.5
Baseline Anxiety2.42.54.5-2.0-1.2-1.21.7-2.12.1-1.8-1.91.81.8-1.80.70.6-0.6
Tail length0.82.34.5-0.9-2.0-2.01.3-1.61.7-1.4-2.11.11.4-1.41.31.7-0.8
Length with tail2.79.717.3-3.7-4.1-4.23.7-3.53.6-3.4-3.62.22.4-2.42.41.4-0.5
Length without tail4.19.119.0-4.4-3.9-4.04.0-3.23.4-3.5-3.01.72.2-2.12.30.4-0.2
Times rat made contact with spout1.41.74.6-1.4-1.9-2.11.6-1.11.3-1.4-1.30.50.9-0.81.10.5-0.2
Lifetime Intake1.11.22.11.31.41.4-1.41.4-1.31.31.2-0.8-0.80.8-0.9-0.30.1
Liver weight, left6.610.517.8-4.2-3.7-3.73.8-4.13.9-3.6-3.62.72.8-2.82.01.2-0.5
Liver weight, right11.218.631.9-5.6-5.1-5.15.4-5.15.0-5.1-4.62.83.8-3.73.31.6-1.1
Locomotor activity0.10.10.40.60.10.0-0.20.3-0.20.10.1-0.40.0-0.00.30.6-0.4
Locomotor testing distance0.50.81.71.30.70.4-1.11.3-1.11.11.0-0.9-0.90.9-0.60.10.3
Locomotor testing rearing0.50.81.71.30.30.4-1.30.9-0.81.30.40.3-1.11.1-1.1-0.40.9
Locomotion in novel chamber0.60.72.3-1.1-0.5-0.60.2-0.10.00.10.40.5-0.80.8-1.5-1.31.5
Locomotion in novel chamber post-restriction1.82.25.70.20.50.6-1.01.0-1.21.41.40.2-1.91.9-2.2-2.42.2
Fecal boli incidents, locomotor time 10.40.41.2-0.2-0.4-0.30.6-1.10.7-0.6-0.90.80.6-0.70.90.1-0.6
Change in fecal boli incidents, locomotor task1.00.92.1-1.2-1.3-1.51.2-0.50.9-1.1-0.7-0.40.8-0.81.00.9-0.4
Time >=10cm from walls, locomotor time 10.10.10.30.20.20.30.00.1-0.1-0.10.1-0.50.2-0.20.40.4-0.5
Bouts of movement, locomotor time 10.70.83.3-0.1-0.6-0.80.4-0.60.8-0.7-0.9-0.11.0-1.01.01.8-1.0
Total resting periods, locomotor time 10.40.52.2-0.1-0.7-0.90.3-0.30.6-0.5-0.7-0.20.6-0.60.81.5-0.6
Rest time, locomotor task time 10.40.41.2-0.3-1.0-1.10.20.6-0.30.10.3-1.0-0.70.8-0.1-0.00.7
Distance moved, locomotor task time 10.40.41.00.20.81.0-0.6-0.0-0.20.50.31.0-0.20.2-0.9-0.90.5
Vertical activity count, locomotor time 10.60.61.50.31.11.2-0.80.3-0.60.70.70.5-0.50.5-1.1-1.20.6
Time >=10cm from walls, locomotor time 20.30.31.5-1.2-0.5-0.40.8-0.60.6-0.7-0.20.10.3-0.30.2-0.40.2
Bouts of movement, locomotor time 20.40.41.31.20.50.5-0.91.1-0.70.80.5-0.5-0.60.6-0.20.20.0
Total resting periods, locomotor time 20.60.61.71.30.60.6-1.11.3-0.91.00.5-0.4-0.70.7-0.40.20.1
Rest time, locomotor task time 20.40.41.31.10.10.1-0.91.0-0.80.80.5-0.6-0.60.7-0.40.40.1
Distance moved, locomotor task time 20.10.10.6-0.80.20.20.3-0.50.2-0.20.20.20.0-0.0-0.4-0.70.4
Vertical activity count, locomotor time 20.10.10.6-0.80.50.50.4-0.30.2-0.40.3-0.20.2-0.2-0.0-0.5-0.0
Light reinforcement 10.20.40.7-0.10.00.1-0.30.8-0.60.50.8-0.6-0.80.8-0.7-0.50.8
Light reinforcement 20.20.20.80.70.50.6-0.20.5-0.50.30.5-0.9-0.20.20.5-0.0-0.4
Bone: marrow area1.94.18.1-2.5-2.8-2.72.6-2.32.2-2.3-2.21.41.4-1.41.60.7-0.1
Bone: maximum diameter6.111.218.3-3.9-3.8-3.83.8-4.33.9-3.7-3.92.73.0-3.02.41.8-0.9
Bone: maximum force5.28.919.1-4.4-4.3-4.33.9-3.33.2-3.3-2.92.01.6-1.61.70.00.6
Bone: maximum moment5.79.721.0-4.5-4.5-4.64.1-3.33.4-3.5-3.12.01.8-1.81.90.40.4
Mean time between licks in bursts1.31.95.3-0.5-0.4-0.51.0-0.30.9-1.3-0.7-1.11.8-1.81.92.3-2.2
Mean num. licks in bursts0.50.61.8-0.6-0.9-1.00.40.2-0.20.10.3-0.1-1.01.0-0.5-1.21.3
Cd content in liver0.50.63.40.20.80.5-0.20.9-0.40.00.8-1.80.3-0.30.50.9-1.0
Co content in liver0.20.20.8-0.8-0.3-0.50.40.0-0.1-0.20.4-0.5-0.40.4-0.2-0.90.6
Cu content in liver0.10.10.3-0.4-0.5-0.20.2-0.20.2-0.2-0.40.50.1-0.10.1-0.30.2
Fe content in liver0.10.10.3-0.40.10.10.3-0.50.3-0.4-0.10.10.4-0.40.2-0.4-0.3
K content in liver0.10.10.30.1-0.10.3-0.30.00.00.2-0.20.5-0.10.1-0.3-0.20.3
Mg content in liver0.40.51.20.50.20.5-0.80.2-0.30.8-0.11.1-0.60.6-1.0-0.90.9
Mn content in liver0.10.10.4-0.5-0.5-0.50.10.20.10.0-0.00.1-0.30.3-0.3-0.10.6
Na content in liver0.80.84.1-0.5-1.0-0.60.4-1.11.1-0.4-1.42.00.4-0.4-0.1-0.40.5
Rb content in liver1.01.22.61.31.51.6-1.41.0-1.11.30.90.1-0.90.9-1.1-1.00.5
Se content in liver0.20.31.20.50.91.1-0.60.2-0.30.50.40.1-0.20.2-0.4-0.60.1
Sr content in liver6.96.39.02.52.62.3-2.92.5-2.73.02.7-0.9-2.72.7-2.8-2.11.8
Zn content in liver1.71.95.50.50.40.6-1.01.0-1.21.41.10.1-1.91.9-1.5-2.42.0
Bone: minimum diameter5.19.517.0-3.7-4.1-3.93.7-3.63.6-3.4-3.62.52.3-2.32.21.1-0.3
Time in familiar zone, hab. session 11.00.92.9-1.0-1.0-1.20.9-1.51.0-0.7-1.21.70.3-0.30.1-0.60.6
Time in novel zone, hab. session 11.51.53.21.61.71.7-1.11.5-1.10.71.1-1.80.2-0.20.40.9-1.5
Total zone transitions, hab. session 10.50.62.2-0.10.50.5-0.5-0.4-0.40.60.60.8-0.80.8-1.3-1.51.2
Total locomotion distance, hab. session 10.10.10.4-0.10.40.40.1-0.50.2-0.20.0-0.10.5-0.50.20.3-0.6
Locomotion velocity, hab. session 10.10.10.3-0.40.10.20.3-0.60.3-0.4-0.0-0.20.6-0.50.20.3-0.5
Time in familiar zone, hab. session 21.51.54.5-0.2-0.0-0.50.8-0.80.9-1.2-0.8-0.51.7-1.71.62.1-2.0
Time in novel zone, hab. session 20.60.62.60.2-0.10.3-0.40.4-0.50.70.40.4-1.11.1-0.8-1.61.2
Total zone transitions, hab. session 20.20.30.9-0.2-0.1-0.0-0.2-0.3-0.10.30.20.7-0.50.5-0.8-0.81.0
Total locomotion distance, hab. session 20.50.61.1-1.1-0.8-0.81.0-1.00.9-1.0-0.80.50.7-0.70.60.3-0.2
Locomotion velocity, hab. session 20.40.61.2-1.1-0.9-0.80.9-1.00.9-0.8-0.80.70.6-0.60.30.10.0
Novel to familiar place preference ratio0.80.82.3-0.5-0.4-0.30.9-0.40.6-1.1-0.5-0.71.1-1.11.50.6-1.4
Novelty place preference0.50.51.8-0.2-0.2-0.10.7-0.10.4-0.8-0.3-0.70.9-0.91.30.5-1.3
Time in novel zone, NPP test1.41.44.1-0.5-0.5-0.41.2-0.70.9-1.4-0.9-0.61.5-1.52.01.0-1.9
Total zone transitions, NPP test0.30.41.5-1.2-1.0-0.80.8-0.70.5-0.5-0.10.1-0.10.1-0.1-0.50.7
Total locomotion distance, NPP test0.20.31.4-1.2-0.7-0.50.9-0.60.5-0.7-0.1-0.20.3-0.30.3-0.10.1
Locomotion velocity, NPP test0.20.30.9-0.9-0.5-0.30.30.2-0.0-0.10.5-0.4-0.40.5-0.6-0.60.9
Intraocular pressure1.21.73.2-1.0-0.3-1.01.2-1.01.3-1.4-1.20.51.8-1.81.31.7-1.5
Delta distance traveled before/after self-admin0.20.30.90.50.60.6-0.40.5-0.40.20.5-1.00.1-0.10.30.5-0.6
Delta ambulatory time before/after self-admin0.20.20.70.20.50.5-0.20.3-0.20.00.4-0.80.3-0.30.30.7-0.7
Parametrial fat weight23.345.575.8-8.7-8.2-8.28.0-8.18.0-7.6-7.44.85.7-5.74.52.8-1.2
Pavlov. Cond. lever latency0.50.61.51.21.21.2-1.20.7-0.60.80.5-0.40.0-0.0-0.20.6-0.6
Pavlov. Cond. magazine entry latency1.01.32.5-1.5-1.5-1.51.6-1.01.2-1.4-1.10.30.8-0.81.00.6-0.3
Pavlov. Cond. change in total contacts3.43.66.5-2.1-2.2-2.32.6-1.72.0-2.3-2.00.71.7-1.72.01.0-1.0
Pavlov. Cond. index score1.41.73.4-1.7-1.7-1.81.8-1.31.4-1.6-1.30.51.0-1.01.20.6-0.3
Pavlov. Cond. latency score1.11.42.9-1.6-1.6-1.61.7-1.11.3-1.5-1.20.40.8-0.81.00.5-0.2
Pavlov. Cond. lever contacts1.11.22.3-1.5-1.5-1.51.5-1.31.2-1.3-1.20.80.7-0.70.80.10.0
Pavlov. Cond. magazine entry number1.41.73.21.61.61.5-1.81.1-1.41.71.2-0.1-1.21.2-1.4-1.00.7
Pavlov. Cond. intertrial magazine entries2.02.46.0-2.5-2.2-2.12.2-1.51.6-1.9-1.20.11.0-1.01.20.2-0.1
Pavlov. Cond. lever-magazine prob. diff.1.62.04.0-1.8-1.8-1.92.0-1.41.5-1.8-1.40.51.1-1.11.30.7-0.4
Pavlov. Cond. response bias0.91.12.3-1.5-1.5-1.41.5-1.01.0-1.2-0.90.40.6-0.60.80.20.0
Pavlov. Cond. lever latency2.63.55.02.11.61.6-2.12.0-2.02.21.8-0.4-2.22.2-1.9-1.51.5
Pavlov. Cond. magazine entry latency0.40.41.1-0.20.40.30.5-1.00.6-0.7-0.40.41.0-1.00.60.5-0.9
Pavlov. Cond. change in total contacts0.91.32.2-1.2-0.7-0.61.1-1.31.2-1.3-1.10.41.5-1.51.21.1-1.1
Pavlov. Cond. index score1.11.42.5-1.3-0.6-0.51.3-1.61.3-1.4-1.00.41.6-1.61.10.9-1.1
Pavlov. Cond. latency score1.01.32.3-1.3-0.6-0.51.2-1.51.3-1.4-1.00.31.5-1.51.10.9-1.0
Pavlov. Cond. lever contacts1.52.13.0-1.7-1.2-1.21.6-1.71.6-1.7-1.40.51.7-1.71.41.1-1.1
Pavlov. Cond. magazine entry number0.20.20.90.6-0.3-0.3-0.50.9-0.50.50.3-0.5-0.60.6-0.20.20.4
Pavlov. Cond. intertrial magazine entries1.52.05.9-2.0-2.4-2.31.6-1.11.5-1.3-1.51.00.5-0.50.40.40.7
Pavlov. Cond. lever-magazine prob. diff.0.70.91.8-1.0-0.3-0.31.0-1.31.0-1.1-0.80.41.3-1.30.90.6-0.9
Pavlov. Cond. response bias1.82.54.2-1.5-0.9-1.01.7-1.71.7-1.9-1.50.32.0-2.01.81.5-1.7
Time in closed arm before self-admin0.20.30.50.60.60.6-0.6-0.1-0.40.60.20.6-0.40.4-0.7-0.60.3
Time in closed arm after self-admin0.80.81.31.00.70.7-0.91.1-1.11.01.1-0.8-1.11.1-0.8-0.60.6
Time in open arm before self-admin0.80.91.71.31.21.2-1.11.2-1.11.10.9-0.6-0.70.7-0.3-0.30.1
Time in open arm after self-admin0.91.03.40.50.30.30.3-0.80.7-0.6-1.00.01.3-1.31.41.8-1.8
Bone: periosteal estimation6.212.824.3-4.7-4.9-4.74.5-4.24.1-4.0-3.92.72.4-2.42.30.90.0
Bone: periosteal perimeter6.711.119.1-4.1-4.4-4.03.8-4.33.9-3.4-4.03.52.3-2.31.80.60.3
Bone: post-yield work2.33.16.3-2.4-1.9-1.82.5-1.81.9-2.3-1.4-0.01.7-1.71.90.8-1.0
Progressive ratio test 1 active lever presses1.21.32.31.31.41.4-1.51.3-1.31.41.3-0.6-0.90.9-1.1-0.40.4
Progressive ratio test 1 breakpoint1.21.32.51.31.41.4-1.61.2-1.21.41.2-0.4-0.90.9-1.3-0.30.4
Progressive ratio test 1 inactive lever presses0.30.30.80.20.90.9-0.60.5-0.30.30.6-0.60.2-0.2-0.50.6-0.4
Progressive ratio test 2 active lever presses0.20.21.0-0.1-0.3-0.3-0.3-0.1-0.00.4-0.21.0-0.40.4-0.7-0.60.9
Progressive ratio test 2 breakpoint0.20.31.1-0.2-0.3-0.3-0.3-0.10.00.4-0.21.0-0.40.4-0.8-0.60.9
Progressive ratio test 2 inactive lever presses0.10.10.4-0.5-0.3-0.30.2-0.20.4-0.4-0.3-0.10.5-0.50.40.6-0.4
Incentive Sensitization - Responses0.80.82.5-1.0-1.3-1.30.6-0.90.9-0.5-1.11.60.2-0.2-0.1-0.30.6
Incentive Sensitization - Breakpoint0.70.72.2-1.0-1.2-1.20.6-0.90.9-0.6-1.11.50.4-0.40.1-0.20.5
Sum of active levers in priming session hrs 5-60.30.32.20.3-0.1-0.1-0.30.20.2-0.0-0.3-0.00.5-0.5-0.01.5-0.6
Progressive ratio3.23.76.22.42.42.4-2.52.1-2.22.32.0-1.0-1.61.6-1.7-0.70.6
Food seeking constrained by brief footshock4.35.312.13.23.53.5-3.02.3-2.52.52.4-1.3-1.31.3-1.5-0.3-0.2
Seeking ratio, punishment vs. effort0.00.00.2-0.2-0.0-0.00.3-0.10.1-0.20.0-0.20.2-0.20.4-0.1-0.2
Retroperitoneal fat weight37.1121.9221.7-14.9-13.8-13.813.8-13.512.9-12.5-11.88.18.4-8.47.32.4-0.8
Reaction time number correct0.30.40.9-0.6-0.7-0.70.7-0.90.7-0.7-0.90.80.6-0.60.60.1-0.2
Reaction time mean minus median0.50.71.80.40.70.8-0.80.1-0.50.80.41.0-0.80.8-1.3-1.41.1
Reaction time mean minus median AUC1.72.24.91.00.91.0-1.40.5-1.01.60.81.4-1.71.7-2.2-2.22.1
Reaction time num false alarms0.81.12.8-1.6-1.7-1.71.7-0.60.8-1.2-0.6-0.30.3-0.30.9-0.20.2
Reaction time num false alarms AUC0.91.23.5-1.6-1.8-1.91.7-0.80.8-1.2-0.70.10.1-0.10.8-0.50.5
Reaction time trials correct on left0.30.40.9-0.6-0.7-0.70.7-0.90.7-0.7-0.90.80.6-0.60.60.1-0.2
Reaction time trials on left0.30.40.9-0.6-0.7-0.70.7-0.90.7-0.7-0.90.80.6-0.60.60.2-0.3
Reaction time mean2.53.56.12.22.42.4-2.51.4-1.92.31.70.4-1.61.6-2.2-1.41.1
Reaction time mean AUC3.44.67.82.42.72.7-2.81.8-2.22.62.00.3-1.91.9-2.5-1.71.3
Median of all reaction times3.04.27.12.42.62.6-2.71.6-2.12.51.90.2-1.81.8-2.4-1.51.1
Reaction time omissions0.10.20.50.30.60.7-0.3-0.00.10.00.10.10.5-0.5-0.00.6-0.6
Reaction time false alarm rate0.50.82.1-1.4-1.4-1.41.4-0.50.6-1.0-0.4-0.30.1-0.10.7-0.30.3
Reaction time premature initiation rate0.30.41.3-0.20.40.1-0.3-0.6-0.30.50.60.5-0.70.7-1.1-1.11.1
Reaction time premature initiations0.20.31.0-0.5-0.1-0.50.1-1.00.20.1-0.00.9-0.30.3-0.7-0.91.0
Std. dev. reaction times0.40.51.30.40.70.7-0.70.0-0.40.70.41.0-0.60.6-1.1-1.20.9
Reaction time trials completed0.30.40.9-0.6-0.7-0.70.7-0.90.7-0.7-0.90.80.6-0.60.60.2-0.3
Reaction time trials AUC0.50.81.3-0.8-1.0-1.11.0-1.10.9-0.9-1.10.90.7-0.70.80.3-0.3
Run reversals in cocaine runway, females0.30.21.00.61.00.9-0.7-0.2-0.20.40.20.40.1-0.1-0.50.1-0.2
Run reversals in cocaine runway, males2.01.92.91.20.80.9-1.61.6-1.51.71.5-0.5-1.71.7-1.6-1.01.4
Latency to leave start box in cocaine runway0.60.72.91.70.70.9-1.20.5-0.30.8-0.40.60.2-0.2-0.01.1-0.8
Latency to leave start box in cocaine runway, F0.30.31.40.7-0.2-0.1-0.40.10.30.1-0.80.60.5-0.50.31.2-0.7
Latency to leave start box in cocaine runway, M0.70.62.21.51.11.1-1.30.6-0.71.00.30.4-0.40.4-0.5-0.1-0.1
Std. dev. time between licks in bursts0.50.62.70.20.70.50.00.5-0.4-0.20.6-1.60.5-0.50.90.8-1.3
Total sessions with >9 infusions1.21.32.20.41.21.2-1.21.4-1.21.21.5-0.5-1.11.1-1.5-1.10.9
Short access day 1 total inactive lever presses0.40.51.7-0.20.60.6-0.10.7-0.1-0.20.6-1.30.7-0.70.20.9-1.1
Short access day 10 total inactive lever presses1.41.65.4-2.3-1.8-1.81.5-1.01.5-1.4-1.10.60.8-0.80.10.30.5
Short access day 1 total infusions0.90.92.00.51.31.3-1.01.2-1.00.91.4-0.8-0.60.6-1.0-0.70.3
Short access day 10 total infusions1.82.03.82.01.71.7-1.81.7-1.71.61.5-1.0-1.11.1-0.9-0.30.0
Short access total infusions1.82.03.11.41.81.8-1.81.6-1.61.61.7-0.8-1.21.2-1.5-0.80.5
Short access day 1 locomotion0.50.61.20.41.01.0-1.00.8-0.60.80.80.1-0.50.5-1.1-0.70.5
Short access day 10 total locomotion0.40.40.80.60.90.9-0.60.6-0.80.60.9-0.5-0.50.5-0.4-0.60.2
Short access total locomotion3.33.45.21.11.91.9-1.91.7-2.02.02.2-0.4-2.02.0-2.2-2.31.7
One hour access (0.3 mA shock)0.40.51.80.80.80.8-0.80.7-0.20.40.1-0.30.4-0.5-0.21.3-0.9
Compulsive drug intake0.60.61.3-0.9-0.5-0.50.9-0.30.8-1.0-0.5-0.51.0-1.00.71.1-0.9
One hour access (shock baseline)0.81.02.21.41.11.1-1.51.3-1.11.20.8-0.5-0.60.6-0.70.3-0.1
Social response proportion1.01.12.8-1.6-1.0-1.31.7-1.00.8-1.4-0.4-0.60.7-0.71.20.0-0.3
Social responses2.93.77.1-2.5-1.8-2.02.3-2.72.3-2.3-2.01.21.8-1.81.40.8-0.6
Social time0.10.10.6-0.1-0.3-0.20.2-0.60.4-0.2-0.60.80.2-0.20.1-0.10.0
Soleus weight1.44.29.5-3.1-3.1-3.02.2-2.12.0-1.6-1.92.50.2-0.2-0.1-1.01.9
Bone: stiffness2.23.48.1-2.8-2.8-2.52.6-2.11.9-2.1-1.71.00.9-0.91.1-0.30.4
Tibialis anterior weight0.20.81.6-1.1-1.3-1.11.0-0.80.9-1.0-1.00.40.8-0.80.90.6-0.4
Time to tail flick, vehicle, before self-admin1.11.12.2-1.1-0.7-0.71.1-1.01.0-1.2-0.8-0.21.3-1.31.50.9-1.1
Time to tail flick, vehicle, after self-admin0.30.30.7-0.7-0.9-0.90.6-0.80.6-0.5-0.70.40.2-0.20.20.30.1
Time to tail flick, test, before self-admin2.22.22.91.31.11.1-1.61.6-1.61.71.6-0.5-1.71.7-1.7-1.51.3
Time to tail flick, test, after self-admin0.91.01.8-1.1-0.3-0.30.9-1.01.1-1.1-0.80.11.3-1.31.01.1-1.1
Delta time to tail flick, vehicle, before/after SA0.80.83.6-0.4-0.9-0.90.2-1.10.7-0.0-1.01.9-0.30.3-0.9-0.61.2
Delta time to tail flick, test, before/after SA5.34.86.7-2.4-1.8-1.82.5-2.32.4-2.6-2.10.22.5-2.52.52.1-1.9
Tibia length0.41.02.1-1.4-1.4-1.41.4-1.31.0-1.2-0.90.70.6-0.60.7-0.10.1
Ambulatory time before self-admin2.02.13.91.31.01.0-1.61.5-1.41.81.30.1-1.81.8-2.0-1.31.6
Ambulatory time after self-admin2.83.04.92.01.91.9-2.22.1-1.92.11.9-0.9-1.61.6-1.9-0.50.8
Bone: tissue strength0.20.20.60.70.80.5-0.50.4-0.20.30.0-0.10.3-0.30.10.7-0.7
Total heroin consumption2.93.47.4-2.0-2.2-2.21.5-2.42.3-1.5-2.42.71.4-1.4-0.00.90.3
Bone: trabecular number2.64.06.9-2.5-2.3-2.22.6-1.92.2-2.5-2.00.71.9-1.91.91.2-0.9
Bone: trabecular spacing1.92.45.52.32.32.3-1.81.9-1.61.41.5-1.6-0.50.5-0.20.4-1.0
Bone: trabecular thickness8.910.619.5-4.3-4.4-4.33.7-3.83.8-3.4-3.73.02.3-2.31.71.10.2
Bone: trabecular tissue density1.01.43.11.31.41.4-1.21.4-1.51.11.6-1.7-0.80.8-0.3-0.1-0.2
Water consumed over 24 hours0.10.20.80.1-0.6-0.90.00.4-0.20.20.1-0.2-0.50.5-0.2-0.30.6
Number of responses in last shaping day0.50.51.30.61.11.1-0.90.7-0.80.71.0-0.5-0.30.3-0.6-0.3-0.0