Hub : Genes

Slc4a1ap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Slc4a1ap	0.02	0.02	2.4e-03	0.01	0.02	0.01	0.01	1.1e-02	6.6e-03	1.3e-02	2.1e-02
2	Adipose	gene expression	Slc4a1ap	0.05	0.05	1.9e-04	0.03	0.02	0.02	0.02	6.6e-04	1.8e-03	9.9e-04	1.8e-03
3	Brain	gene expression	Slc4a1ap	0.08	0.08	3.0e-05	0.05	0.04	0.04	0.04	2.9e-05	7.4e-05	4.6e-05	4.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	4.9	8.3	9.3	3.0	-3.0	-2.6
Area under the delay curve	0.3	0.3	0.8	0.4	-0.9	0.2
BMI with tail	0.4	1.4	1.4	-1.1	1.2	1.2
BMI without tail	0.2	0.5	0.7	-0.7	0.9	0.4
Body weight	1.8	7.4	7.9	-2.8	2.8	2.6
Weight adjusted by age	0.1	0.1	0.2	-0.1	0.1	-0.4
Bone surface	2.2	3.9	4.9	2.2	-2.0	-1.7
Bone volume	2.4	4.1	5.0	2.2	-2.1	-1.7
Breakpoint value in progressive ratio session	1.5	1.7	2.1	1.1	-1.3	-1.5
Number of licking bursts	0.1	0.2	0.3	0.4	-0.5	0.1
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	0.1	0.2
Locomotion velocity, session 1	0.1	0.1	0.1	-0.2	0.3	0.2
Locomotion distance, session 1	1.7	2.1	2.7	1.6	-1.6	-1.1
Locomotion velocity, session 2	0.2	0.3	0.5	-0.4	0.4	0.7
Locomotion distance, session 2	0.0	0.0	0.0	0.0	0.1	0.2
Locomotion velocity, session 3	0.6	0.7	1.0	0.8	-0.7	-1.0
Locomotion distance, session 3	0.8	0.9	1.0	1.0	-1.0	-0.8
Stereotopy head waving bouts, day 3	1.9	2.2	2.9	1.4	-1.3	-1.7
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.3	-0.3	-0.6
Locomotion velocity, session 7	0.8	0.8	1.0	1.0	-0.8	-0.9
Locomotion distance, session 7	0.0	0.0	0.0	0.1	0.1	0.0
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	0.0	0.1
Stereotopy head waving duration, day 7	0.4	0.5	0.6	0.6	-0.7	-0.8
Locomotion velocity, session 8	0.1	0.1	0.2	0.3	0.0	-0.4
Locomotion distance, session 8	0.2	0.3	0.4	0.7	-0.6	-0.2
Degree of sensitization distance	1.0	1.0	1.0	-1.0	1.0	1.0
Degree of sensitization stereotypy	0.1	0.2	0.3	-0.4	0.2	0.5
Conditioned locomotion	3.3	3.9	4.0	2.0	-2.0	-1.9
Cocaine response after cond. corrected	1.1	1.2	1.7	1.2	-1.3	-0.7
Cocaine response after cond. not corrected	2.2	2.4	3.2	1.6	-1.8	-1.1
Cocaine response before conditioning	1.1	1.3	1.5	1.1	-1.1	-1.2
Saline control response	0.6	0.8	0.9	0.9	-0.7	-1.0
Bone: connectivity density	4.9	7.8	8.5	2.9	-2.9	-2.5
Bone: cortical apparent density	0.3	0.4	0.6	0.7	-0.7	-0.3
Bone: cortical area	0.2	0.3	0.5	0.7	-0.6	-0.2
Bone: cortical porosity	1.5	1.6	2.4	1.2	-1.0	-1.6
Bone: cortical porosity	1.2	1.3	1.7	1.1	-0.9	-1.3
Bone: cortical thickness	0.1	0.2	0.5	-0.1	0.2	0.7
Bone: cortical thickness	1.4	1.7	1.9	1.4	-1.4	-1.1
Bone: cortical tissue density	0.2	0.3	0.4	0.6	-0.6	-0.2
Condit. Reinf. active minus inactive responses	0.5	0.5	0.7	-0.7	0.6	0.9
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.6	-0.8	0.6	0.6
Condit. Reinf. active responses	0.2	0.3	0.5	0.6	-0.7	-0.1
Condit. Reinf. inactive responses	1.5	1.8	2.3	1.5	-1.5	-0.9
Incentive salience index mean	0.0	0.1	0.1	0.2	-0.3	-0.0
Condit. Reinf. lever presses	0.6	0.9	1.2	1.0	-1.1	-0.6
Condit. Reinf. active minus inactive responses	4.3	5.3	5.7	2.2	-2.3	-2.4
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.2	1.1	-1.1	-1.1
Condit. Reinf. active responses	3.6	5.0	5.8	2.1	-2.2	-2.4
Condit. Reinf. inactive responses	2.0	2.4	2.7	1.5	-1.6	-1.6
Condit. Reinf. lever presses	2.1	2.9	3.3	1.7	-1.8	-1.6
Condit. Reinf. lever reinforcers received	3.1	4.4	5.2	2.0	-2.0	-2.3
Conditioned reinforcement - actives	0.9	0.9	2.1	0.7	-0.3	-1.4
Conditioned reinforcement - inactives	2.4	2.7	3.2	1.7	-1.4	-1.8
Conditioned locomotion	0.5	0.6	1.2	-0.1	0.7	-1.1
Patch foraging indifference point 0 sec	0.3	0.5	0.6	-0.8	0.7	0.5
Patch foraging indifference point AUC	1.9	2.2	2.5	1.6	-1.4	-1.4
Delay disc. indifference point, 0s delay	2.6	2.9	4.8	-1.5	1.2	2.2
Delay disc. indifference point, 16s delay	0.6	0.6	1.4	0.8	-1.2	-0.1
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	-0.5	0.3	0.8
Delay disc. indifference point, 24s delay	2.8	2.7	5.1	1.6	-2.3	-0.7
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.1	-0.2	0.2
Delay disc. indifference point, 8s delay	0.3	0.4	0.8	0.5	-0.9	0.0
Indifference point function ln k	0.0	0.0	0.1	-0.2	0.2	-0.0
Indifference point function log k	0.0	0.0	0.1	-0.2	0.2	-0.0
Patch foraging total patch changes 0 sec	0.2	0.3	0.4	-0.6	0.6	0.5
Patch foraging total patch changes 12 sec	0.8	1.0	1.0	-1.0	1.0	1.0
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.1	0.2	0.0
Patch foraging total patch changes 24 sec	1.0	1.2	1.6	-1.1	1.3	0.9
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	-0.2	0.2	0.2
Patch foraging time to switch 0 sec	0.0	0.0	0.1	0.1	-0.3	0.0
Patch foraging water rate 0 sec	0.0	0.0	0.1	-0.1	0.3	-0.1
Patch foraging water rate 12 sec	1.7	2.6	2.7	-1.6	1.6	1.6
Patch foraging water rate 18 sec	0.7	1.0	1.0	-1.0	1.0	0.9
Patch foraging water rate 24 sec	1.8	2.5	2.8	-1.7	1.5	1.5
Patch foraging water rate 6 sec	1.4	2.0	2.1	-1.4	1.5	1.4
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.3	0.7	0.0
Distance traveled before self-admin	0.0	0.0	0.1	0.2	-0.3	-0.1
Distance traveled after self-admin	0.6	0.7	1.0	-0.8	0.6	1.0
Extensor digitorum longus weight	4.5	17.7	18.5	4.3	-4.3	-4.0
Bone: elastic displacement	1.0	1.1	1.2	1.0	-1.1	-1.1
Bone: elastic work	1.2	1.5	1.8	1.2	-1.3	-1.1
Bone: endosteal estimation	0.3	0.7	0.8	0.9	-0.8	-0.8
Bone: endosteal perimeter	0.1	0.2	0.3	0.6	-0.6	-0.3
Epididymis fat weight	14.5	33.8	36.0	-6.0	6.0	5.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.2	0.1	0.1
Delta time in open arm before/after self-admin	0.4	0.3	0.4	0.6	-0.5	-0.6
Diff in mean of infusions in LGA sessions	0.3	0.3	0.5	0.5	-0.3	-0.7
Delay discount exponential model param	0.6	0.7	1.4	-0.7	1.2	0.1
Extinction: sum of active levers before priming	0.6	0.6	0.8	0.8	-0.9	-0.5
Active lever presses in extinction session 6	0.4	0.4	1.0	0.4	-0.2	-1.0
Bone: final force	0.1	0.1	0.2	0.4	-0.3	-0.2
Bone: final moment	0.1	0.1	0.2	0.5	-0.4	-0.2
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.5	-0.5	-0.3
Glucose	0.2	0.4	0.6	-0.6	0.8	0.3
Heart weight	10.4	14.7	16.4	-3.7	4.1	3.7
Delay discount hyperbolic model param	0.5	0.6	1.2	-0.7	1.1	0.1
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.2	0.0	-0.4
Intermittent access intake escalation	0.0	0.0	0.1	-0.1	0.3	-0.2
Intermittent access intake escalation 2	0.4	0.4	0.6	-0.5	0.7	0.5
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.2	0.1	-0.3
Intermitt. access day 15 inactive lever presses	6.5	7.1	8.7	2.8	-2.3	-2.9
Intermitt. access escalation Index	0.3	0.3	0.4	-0.4	0.6	0.4
Intermittent access day 1 total infusions	4.7	5.5	5.8	2.4	-2.2	-2.4
Intermittent access day 15 total infusions	1.9	2.1	2.5	1.5	-1.2	-1.6
Intermittent access terminal intake (last 3 days)	1.5	1.7	2.1	1.3	-1.1	-1.4
Intermittent access total infusions	1.9	2.1	2.7	1.4	-1.3	-1.6
Intermittent access day 1 locomotion	2.0	2.1	2.5	1.6	-1.4	-1.4
Intermittent access day 15 total locomotion	0.5	0.6	0.8	0.8	-0.6	-0.9
Intermittent access total locomotion	0.2	0.2	0.5	0.5	-0.2	-0.7
Intermittent access standard deviation	0.1	0.1	0.3	0.3	0.0	-0.6
Left kidney weight	0.0	0.0	0.0	-0.0	0.0	0.2
Right kidney weight	1.0	2.8	4.1	-1.6	1.4	2.0
Cocaine induced anxiety	0.2	0.2	0.4	0.5	-0.2	-0.6
Post-drug Anxiety	0.9	1.0	1.6	-0.8	0.9	1.3
Baseline Anxiety	1.2	1.3	2.2	-1.0	0.8	1.5
Tail length	0.1	0.3	0.4	-0.6	0.6	0.3
Length with tail	1.3	4.9	5.4	-2.3	2.2	2.1
Length without tail	0.7	1.5	1.8	-1.2	1.1	1.3
Times rat made contact with spout	2.1	2.4	3.1	1.6	-1.8	-1.2
Lifetime Intake	2.7	3.0	4.2	1.7	-1.5	-2.0
Liver weight, left	1.3	2.1	2.1	-1.4	1.5	1.5
Liver weight, right	9.5	15.7	16.6	-3.9	3.9	4.1
Locomotor activity	0.2	0.2	0.5	-0.4	0.1	0.7
Locomotor testing distance	0.2	0.3	0.5	0.5	-0.7	-0.4
Locomotor testing rearing	0.9	1.5	2.4	1.0	-1.0	-1.6
Locomotion in novel chamber	1.0	1.3	1.5	-1.1	1.2	1.0
Locomotion in novel chamber post-restriction	1.8	2.2	2.6	-1.6	1.4	1.4
Fecal boli incidents, locomotor time 1	0.2	0.3	0.4	0.6	-0.4	-0.5
Change in fecal boli incidents, locomotor task	4.2	3.9	4.2	-2.1	1.9	2.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.1	-0.2	0.3
Bouts of movement, locomotor time 1	2.2	2.4	3.0	1.7	-1.6	-1.3
Total resting periods, locomotor time 1	2.5	2.7	3.3	1.8	-1.6	-1.5
Rest time, locomotor task time 1	0.1	0.1	0.2	0.2	-0.0	-0.5
Distance moved, locomotor task time 1	1.0	1.1	1.5	-1.1	0.8	1.2
Vertical activity count, locomotor time 1	0.5	0.5	0.9	-0.6	0.3	1.0
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.2	-0.1	-0.4
Bouts of movement, locomotor time 2	0.2	0.2	0.4	-0.3	0.4	0.6
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.0	0.2	0.3
Rest time, locomotor task time 2	1.5	1.7	1.9	1.4	-1.4	-1.2
Distance moved, locomotor task time 2	0.9	1.1	1.3	-1.1	1.0	1.0
Vertical activity count, locomotor time 2	0.6	0.6	0.8	-0.9	0.9	0.6
Light reinforcement 1	4.0	7.2	8.1	2.8	-2.8	-2.4
Light reinforcement 2	3.2	4.3	5.3	2.3	-2.2	-1.7
Bone: marrow area	0.4	0.8	0.9	0.9	-0.9	-0.8
Bone: maximum diameter	0.7	1.4	1.7	1.3	-1.3	-0.9
Bone: maximum force	0.0	0.0	0.0	0.1	0.0	0.0
Bone: maximum moment	0.0	0.0	0.1	0.2	-0.1	-0.1
Mean time between licks in bursts	2.4	3.4	3.6	-1.9	1.8	1.9
Mean num. licks in bursts	0.1	0.1	0.2	0.3	-0.3	-0.4
Cd content in liver	0.0	0.0	0.1	0.1	-0.0	0.3
Co content in liver	5.4	6.3	6.8	2.6	-2.6	-2.3
Cu content in liver	0.0	0.0	0.1	0.2	-0.2	-0.3
Fe content in liver	0.1	0.1	0.1	-0.2	0.3	-0.4
K content in liver	0.1	0.1	0.3	-0.2	0.2	0.5
Mg content in liver	0.2	0.2	0.3	-0.4	0.4	0.6
Mn content in liver	0.7	0.8	1.2	0.8	-0.7	-1.1
Na content in liver	0.4	0.4	0.5	0.7	-0.5	-0.7
Rb content in liver	0.0	0.0	0.0	-0.1	0.1	0.0
Se content in liver	0.4	0.5	0.7	-0.7	0.9	0.3
Sr content in liver	0.2	0.2	0.4	-0.2	0.1	0.7
Zn content in liver	1.5	1.6	1.8	-1.2	1.2	1.3
Bone: minimum diameter	0.1	0.3	0.4	-0.4	0.5	0.7
Time in familiar zone, hab. session 1	0.9	0.8	1.0	-0.9	1.0	0.8
Time in novel zone, hab. session 1	0.5	0.5	0.7	-0.8	0.8	0.4
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.4	-0.4	0.0
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.4	-0.3	-0.2
Locomotion velocity, hab. session 1	0.9	1.2	1.5	1.2	-1.2	-0.8
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.0	0.1	-0.0
Time in novel zone, hab. session 2	0.4	0.4	0.5	-0.7	0.6	0.6
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	-0.5	-0.0
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.6	-0.6	-0.2
Locomotion velocity, hab. session 2	0.4	0.5	0.7	0.8	-0.8	-0.5
Novel to familiar place preference ratio	0.9	0.9	1.1	-1.0	0.8	1.0
Novelty place preference	1.4	1.5	1.6	-1.2	1.1	1.3
Time in novel zone, NPP test	1.6	1.7	1.9	-1.4	1.2	1.3
Total zone transitions, NPP test	1.4	1.9	2.1	1.5	-1.5	-1.2
Total locomotion distance, NPP test	1.9	2.7	2.7	1.7	-1.6	-1.6
Locomotion velocity, NPP test	3.2	4.6	5.0	2.2	-2.2	-1.9
Intraocular pressure	4.8	6.6	8.4	-2.6	2.2	2.9
Delta distance traveled before/after self-admin	1.5	1.6	1.8	-1.3	1.3	1.2
Delta ambulatory time before/after self-admin	0.3	0.3	0.4	-0.5	0.6	0.6
Parametrial fat weight	6.0	11.8	13.5	-3.3	3.3	3.7
Pavlov. Cond. lever latency	1.6	2.0	2.3	-1.5	1.4	1.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	-0.2	0.0
Pavlov. Cond. index score	0.6	0.8	1.0	1.0	-0.9	-0.7
Pavlov. Cond. latency score	0.6	0.7	0.9	1.0	-0.9	-0.7
Pavlov. Cond. lever contacts	1.0	1.2	1.4	1.2	-1.2	-0.9
Pavlov. Cond. magazine entry number	0.4	0.4	0.6	-0.7	0.7	0.6
Pavlov. Cond. intertrial magazine entries	1.3	1.6	1.8	1.3	-1.4	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.1	1.5	-1.4	-1.2
Pavlov. Cond. response bias	1.4	1.7	1.9	1.4	-1.3	-1.2
Pavlov. Cond. lever latency	1.7	2.3	2.5	-1.6	1.6	1.4
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.5	-0.3	-0.5
Pavlov. Cond. change in total contacts	0.6	0.8	1.0	1.0	-1.0	-0.7
Pavlov. Cond. index score	0.9	1.2	1.4	1.2	-1.1	-1.0
Pavlov. Cond. latency score	0.9	1.1	1.3	1.1	-1.0	-1.0
Pavlov. Cond. lever contacts	0.9	1.2	1.5	1.2	-1.2	-0.9
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	0.2	0.2
Pavlov. Cond. intertrial magazine entries	3.1	4.0	4.4	-2.1	1.9	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.0	1.0	-0.9	-0.8
Pavlov. Cond. response bias	1.6	2.2	2.5	1.6	-1.6	-1.3
Time in closed arm before self-admin	0.5	0.5	0.7	-0.8	0.9	0.5
Time in closed arm after self-admin	1.3	1.3	1.6	-1.3	1.2	0.8
Time in open arm before self-admin	0.1	0.1	0.3	0.3	-0.5	0.3
Time in open arm after self-admin	2.0	2.1	2.7	1.6	-1.6	-1.0
Bone: periosteal estimation	0.5	1.0	1.3	1.1	-1.0	-0.7
Bone: periosteal perimeter	0.2	0.3	0.4	0.6	-0.6	-0.2
Bone: post-yield work	0.4	0.6	0.8	0.7	-0.6	-0.9
Progressive ratio test 1 active lever presses	1.2	1.2	2.4	1.0	-0.6	-1.6
Progressive ratio test 1 breakpoint	1.0	1.1	2.1	0.9	-0.5	-1.5
Progressive ratio test 1 inactive lever presses	2.9	3.2	5.8	1.7	-1.1	-2.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.0	0.2	-0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.1	0.1	-0.5
Progressive ratio test 2 inactive lever presses	1.6	1.8	2.9	1.3	-0.9	-1.7
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.3	0.3	0.3
Incentive Sensitization - Breakpoint	0.3	0.3	0.3	-0.5	0.6	0.5
Sum of active levers in priming session hrs 5-6	1.0	0.9	1.4	1.0	-1.2	-0.5
Progressive ratio	0.1	0.1	0.2	-0.2	0.2	-0.5
Food seeking constrained by brief footshock	3.6	4.5	6.6	1.9	-1.8	-2.6
Seeking ratio, punishment vs. effort	0.6	0.8	1.0	1.0	-1.0	-0.6
Retroperitoneal fat weight	21.3	70.0	72.9	-8.5	8.5	8.0
Reaction time number correct	0.5	0.7	1.0	0.9	-1.0	-0.6
Reaction time mean minus median	0.0	0.0	0.0	-0.1	0.2	-0.2
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.3	0.3	0.1
Reaction time num false alarms	0.2	0.2	0.5	0.4	-0.7	0.2
Reaction time num false alarms AUC	0.3	0.4	0.7	0.6	-0.8	0.3
Reaction time trials correct on left	0.5	0.7	1.0	0.9	-1.0	-0.6
Reaction time trials on left	0.6	0.8	1.0	1.0	-1.0	-0.6
Reaction time mean	1.2	1.7	1.9	-1.3	1.2	1.4
Reaction time mean AUC	1.0	1.4	1.5	-1.2	1.1	1.2
Median of all reaction times	1.3	1.8	2.4	-1.3	1.2	1.5
Reaction time omissions	0.1	0.1	0.1	0.3	-0.3	-0.4
Reaction time false alarm rate	0.1	0.1	0.3	-0.0	-0.2	0.6
Reaction time premature initiation rate	0.2	0.2	0.2	-0.5	0.5	0.5
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.1	0.1
Std. dev. reaction times	0.4	0.5	0.6	-0.8	0.8	0.6
Reaction time trials completed	0.6	0.8	1.0	1.0	-1.0	-0.6
Reaction time trials AUC	0.7	1.0	1.3	1.1	-1.1	-0.8
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.2	-0.0	0.3
Run reversals in cocaine runway, males	0.3	0.3	0.5	0.5	-0.7	-0.4
Latency to leave start box in cocaine runway	0.5	0.5	0.6	0.7	-0.6	-0.8
Latency to leave start box in cocaine runway, F	0.6	0.6	0.7	0.8	-0.8	-0.7
Latency to leave start box in cocaine runway, M	0.5	0.5	1.0	0.6	-0.3	-1.0
Std. dev. time between licks in bursts	0.1	0.2	0.3	-0.3	0.4	0.5
Total sessions with >9 infusions	2.2	2.4	4.5	1.3	-1.0	-2.1
Short access day 1 total inactive lever presses	4.1	4.6	5.1	2.3	-1.9	-2.3
Short access day 10 total inactive lever presses	0.8	0.9	1.1	1.0	-0.9	-1.0
Short access day 1 total infusions	4.4	4.6	7.5	2.0	-1.6	-2.7
Short access day 10 total infusions	3.6	4.0	5.0	2.0	-1.8	-2.2
Short access total infusions	2.5	2.8	4.6	1.5	-1.3	-2.1
Short access day 1 locomotion	5.9	6.4	9.3	2.4	-2.0	-3.0
Short access day 10 total locomotion	0.5	0.5	0.8	0.9	-0.4	-0.8
Short access total locomotion	0.4	0.4	0.8	0.6	-0.2	-0.9
One hour access (0.3 mA shock)	1.6	1.9	2.2	1.4	-1.3	-1.5
Compulsive drug intake	0.3	0.3	0.7	-0.4	-0.0	0.8
One hour access (shock baseline)	1.5	1.7	2.9	1.2	-0.9	-1.7
Social response proportion	0.4	0.4	0.6	-0.7	0.8	0.4
Social responses	0.2	0.2	0.3	-0.4	0.6	0.4
Social time	0.9	1.1	2.1	-1.0	1.4	0.5
Soleus weight	4.4	12.9	15.0	3.7	-3.9	-3.1
Bone: stiffness	0.0	0.1	0.1	-0.2	0.3	0.3
Tibialis anterior weight	3.4	11.8	12.8	3.6	-3.6	-3.1
Time to tail flick, vehicle, before self-admin	2.3	2.4	2.8	-1.7	1.7	1.3
Time to tail flick, vehicle, after self-admin	4.1	4.3	5.3	-2.2	2.3	1.7
Time to tail flick, test, before self-admin	0.5	0.5	0.6	0.7	-0.6	-0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	0.4	0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	0.3	-0.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.3	0.6	-0.5	-0.5
Tibia length	2.5	7.1	7.9	-2.7	2.8	2.5
Ambulatory time before self-admin	0.2	0.2	0.3	0.4	-0.5	-0.0
Ambulatory time after self-admin	0.5	0.5	0.9	-0.7	0.5	0.9
Bone: tissue strength	0.8	0.8	1.1	-0.8	0.7	1.0
Total heroin consumption	3.0	3.6	3.9	1.9	-2.0	-1.8
Bone: trabecular number	4.0	6.2	6.8	2.6	-2.6	-2.3
Bone: trabecular spacing	3.0	3.9	4.2	-2.0	1.8	2.0
Bone: trabecular thickness	0.6	0.7	0.8	0.9	-0.8	-0.8
Bone: trabecular tissue density	0.1	0.2	0.2	0.4	-0.3	-0.5
Water consumed over 24 hours	1.4	1.6	2.2	1.5	-1.5	-0.8
Number of responses in last shaping day	0.4	0.4	1.1	0.4	-0.2	-1.1