Hub : Genes

LOC102550729

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC102550729	0.05	0.03	4.7e-06	0.06	0.05	0.04	0.05	4.1e-06	1.5e-05	2.0e-04	2.3e-05
2	Adipose	gene expression	LOC102550729	0.04	0.03	6.9e-05	0.03	0.04	0.04	0.03	1.1e-04	4.1e-05	6.3e-05	1.0e-04
3	PL	gene expression	LOC102550729	0.04	0.04	1.5e-03	0.01	0.01	0.02	0.01	3.8e-02	8.5e-03	4.4e-03	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.7	1.2	2.7	-1.6	1.0	0.2
Area under the delay curve	1.9	2.0	3.4	-1.0	1.3	-1.8
BMI with tail	20.2	65.4	93.7	-9.7	8.5	-5.5
BMI without tail	15.2	31.4	44.9	-6.7	5.8	-3.9
Body weight	18.4	77.2	113.6	-10.7	9.2	-5.8
Weight adjusted by age	5.2	5.9	7.9	-2.8	2.5	-1.9
Bone surface	0.8	1.5	2.9	-1.7	1.2	-0.1
Bone volume	2.3	4.0	6.7	-2.6	2.1	-0.8
Breakpoint value in progressive ratio session	3.4	3.8	4.8	-2.2	1.9	-1.7
Number of licking bursts	0.0	0.0	0.1	-0.3	-0.0	-0.1
Context. condit. distance diff. score	0.2	0.2	0.3	0.3	-0.5	0.5
Locomotion velocity, session 1	1.2	1.3	1.4	1.2	-1.2	1.1
Locomotion distance, session 1	1.7	2.2	3.6	1.9	-1.4	1.0
Locomotion velocity, session 2	1.0	1.2	1.8	1.3	-1.0	0.9
Locomotion distance, session 2	0.1	0.1	0.2	-0.2	0.4	-0.1
Locomotion velocity, session 3	1.9	2.3	3.3	1.8	-1.5	1.1
Locomotion distance, session 3	1.1	1.2	1.4	1.2	-1.1	1.0
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	0.5	-0.1	-0.2
Stereotopy head waving duration, day 3	0.2	0.3	0.6	0.3	0.2	-0.8
Locomotion velocity, session 7	0.2	0.2	0.2	0.4	-0.4	0.5
Locomotion distance, session 7	0.1	0.1	0.4	-0.2	-0.0	0.6
Stereotopy head waving bouts, day 7	0.5	0.5	1.4	-0.3	0.4	-1.2
Stereotopy head waving duration, day 7	0.4	0.5	1.4	-0.1	0.2	-1.2
Locomotion velocity, session 8	2.8	3.4	3.7	1.8	-1.9	1.8
Locomotion distance, session 8	1.5	2.1	3.0	1.2	-1.4	1.7
Degree of sensitization distance	0.8	0.8	1.5	-1.2	0.9	-0.3
Degree of sensitization stereotypy	1.2	1.3	2.3	-0.9	0.8	-1.5
Conditioned locomotion	0.0	0.0	0.1	0.1	0.0	-0.2
Cocaine response after cond. corrected	3.2	3.6	4.7	2.2	-1.7	1.8
Cocaine response after cond. not corrected	4.7	5.2	6.0	2.5	-2.2	2.2
Cocaine response before conditioning	0.2	0.2	0.3	0.1	-0.6	0.6
Saline control response	0.2	0.2	0.5	0.1	0.4	-0.7
Bone: connectivity density	0.3	0.4	1.1	0.1	-0.4	1.0
Bone: cortical apparent density	5.4	7.2	10.5	3.2	-2.8	1.8
Bone: cortical area	9.2	13.9	19.9	-4.5	3.9	-2.6
Bone: cortical porosity	0.6	0.7	1.1	-1.1	0.8	-0.6
Bone: cortical porosity	1.6	1.8	2.6	-1.6	1.3	-1.0
Bone: cortical thickness	5.8	9.5	12.5	-3.5	3.3	-2.3
Bone: cortical thickness	7.5	8.7	10.1	-2.9	3.2	-2.7
Bone: cortical tissue density	6.3	8.3	11.9	3.4	-3.0	2.0
Condit. Reinf. active minus inactive responses	4.0	4.5	6.0	1.7	-2.1	2.5
Condit. Reinf. active-inactive response ratio	2.8	3.0	3.4	1.5	-1.8	1.8
Condit. Reinf. active responses	1.4	1.7	3.7	0.5	-1.1	1.9
Condit. Reinf. inactive responses	0.4	0.5	1.0	-1.0	0.5	0.5
Incentive salience index mean	3.1	3.8	5.7	1.5	-1.8	2.4
Condit. Reinf. lever presses	1.5	2.0	3.2	1.1	-1.2	1.8
Condit. Reinf. active minus inactive responses	1.5	1.8	3.5	-1.9	1.2	-0.8
Condit. Reinf. active-inactive response ratio	3.3	3.4	4.8	-2.2	1.7	-1.6
Condit. Reinf. active responses	1.4	2.0	4.0	-2.0	1.2	-0.8
Condit. Reinf. inactive responses	0.3	0.3	0.8	-0.9	0.4	-0.1
Condit. Reinf. lever presses	1.0	1.3	2.3	-1.5	1.1	-0.6
Condit. Reinf. lever reinforcers received	0.6	0.8	2.1	-1.4	0.7	-0.2
Conditioned reinforcement - actives	5.0	5.0	5.7	2.4	-2.3	2.0
Conditioned reinforcement - inactives	0.5	0.6	0.8	0.9	-0.8	0.6
Conditioned locomotion	4.7	5.6	5.8	2.4	-2.3	2.4
Patch foraging indifference point 0 sec	4.6	7.5	8.8	-3.0	2.9	-2.3
Patch foraging indifference point AUC	1.0	1.2	1.6	-0.9	1.0	-1.3
Delay disc. indifference point, 0s delay	1.1	1.2	1.4	-0.9	1.1	-1.2
Delay disc. indifference point, 16s delay	1.0	1.0	1.8	-0.7	0.8	-1.4
Delay disc. indifference point, 2s delay	0.4	0.5	1.1	-0.1	0.5	-1.0
Delay disc. indifference point, 24s delay	1.4	1.4	2.2	-0.9	1.1	-1.5
Delay disc. indifference point, 4s delay	1.1	1.1	2.1	-0.6	0.9	-1.4
Delay disc. indifference point, 8s delay	0.7	0.7	1.6	-0.3	0.7	-1.3
Indifference point function ln k	0.0	0.1	0.1	-0.2	0.1	0.3
Indifference point function log k	0.0	0.1	0.1	-0.2	0.1	0.3
Patch foraging total patch changes 0 sec	5.8	9.4	11.0	-3.3	3.2	-2.6
Patch foraging total patch changes 12 sec	3.8	4.9	6.2	-2.5	2.3	-1.8
Patch foraging total patch changes 18 sec	1.8	2.4	2.7	-1.7	1.6	-1.3
Patch foraging total patch changes 24 sec	0.8	1.0	1.1	-0.9	1.0	-1.1
Patch foraging total patch changes 6 sec	4.7	6.9	7.5	-2.7	2.7	-2.4
Patch foraging time to switch 0 sec	1.5	2.3	2.5	1.5	-1.6	1.4
Patch foraging water rate 0 sec	3.0	4.8	5.3	-2.3	2.3	-2.0
Patch foraging water rate 12 sec	2.8	4.3	5.6	-2.4	2.1	-1.7
Patch foraging water rate 18 sec	1.3	1.8	2.2	-1.2	1.5	-1.3
Patch foraging water rate 24 sec	4.0	5.6	6.8	-2.3	2.6	-2.2
Patch foraging water rate 6 sec	1.7	2.5	3.1	-1.7	1.8	-1.2
Seeking ratio, delayed vs. immediate footshock	9.7	11.2	12.0	3.4	-3.5	3.1
Distance traveled before self-admin	0.2	0.2	0.6	0.3	0.2	-0.7
Distance traveled after self-admin	0.7	0.8	1.6	1.3	-0.8	0.2
Extensor digitorum longus weight	1.5	5.9	9.0	-3.0	2.5	-1.6
Bone: elastic displacement	0.7	0.8	1.4	-0.5	0.9	-1.2
Bone: elastic work	3.4	4.4	5.5	-1.8	2.3	-2.2
Bone: endosteal estimation	1.2	2.6	4.0	-2.0	1.7	-0.9
Bone: endosteal perimeter	3.4	7.0	8.6	-2.9	2.7	-2.2
Epididymis fat weight	22.7	52.8	81.5	-9.0	7.4	-4.7
Delta time in closed arm before/after self-admin	0.7	0.6	1.0	0.6	-0.7	1.0
Delta time in open arm before/after self-admin	0.2	0.2	0.6	-0.8	-0.0	0.2
Diff in mean of infusions in LGA sessions	1.2	1.3	1.8	-1.1	1.0	-1.3
Delay discount exponential model param	2.2	2.3	3.9	1.1	-1.4	2.0
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.0	-0.1	-0.1
Active lever presses in extinction session 6	4.2	4.0	4.6	-1.9	2.0	-2.2
Bone: final force	6.3	10.3	13.7	-3.7	3.5	-2.3
Bone: final moment	6.5	10.6	14.4	-3.8	3.5	-2.2
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.6	0.4	0.1
Glucose	8.1	12.3	15.6	-3.9	3.4	-3.1
Heart weight	8.2	11.6	15.5	-3.9	3.5	-2.7
Delay discount hyperbolic model param	1.8	1.9	3.4	0.9	-1.3	1.9
Intermittent access intake day 1-15 change	0.3	0.3	0.5	-0.3	0.5	-0.7
Intermittent access intake escalation	0.1	0.1	0.2	-0.1	0.3	-0.5
Intermittent access intake escalation 2	0.3	0.3	0.4	-0.6	0.5	-0.4
Intermitt. access day 1 inactive lever presses	0.9	1.0	1.1	-1.0	1.0	-1.0
Intermitt. access day 15 inactive lever presses	2.9	3.2	4.1	-1.4	1.9	-2.0
Intermitt. access escalation Index	0.2	0.2	0.3	0.3	-0.4	0.5
Intermittent access day 1 total infusions	0.4	0.5	0.7	0.9	-0.7	0.4
Intermittent access day 15 total infusions	0.1	0.1	0.3	0.6	-0.2	-0.0
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.1	0.3	0.0	-0.3
Intermittent access total infusions	0.5	0.6	1.1	1.1	-0.7	0.4
Intermittent access day 1 locomotion	2.2	2.3	3.6	1.9	-1.5	1.1
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.2	0.3	-0.4
Intermittent access total locomotion	1.1	1.3	1.9	1.4	-1.1	0.9
Intermittent access standard deviation	0.1	0.1	0.1	0.3	-0.3	0.2
Left kidney weight	6.9	19.4	28.8	-5.4	4.8	-2.5
Right kidney weight	6.7	18.9	27.3	-5.2	4.8	-2.6
Cocaine induced anxiety	3.3	3.8	4.2	2.0	-2.0	1.8
Post-drug Anxiety	0.8	0.8	1.1	0.9	-1.0	0.8
Baseline Anxiety	1.4	1.5	1.5	-1.2	1.2	-1.2
Tail length	1.0	2.9	4.2	-2.0	1.7	-1.3
Length with tail	2.4	8.6	12.9	-3.6	3.0	-2.0
Length without tail	2.4	5.2	8.6	-2.9	2.4	-1.2
Times rat made contact with spout	0.8	0.9	1.6	-1.3	1.0	-0.4
Lifetime Intake	0.8	0.9	1.7	1.3	-0.9	0.5
Liver weight, left	4.1	6.5	9.3	-3.1	2.6	-1.9
Liver weight, right	5.7	9.5	15.3	-3.9	3.1	-1.9
Locomotor activity	0.1	0.1	0.2	0.3	-0.4	0.4
Locomotor testing distance	0.3	0.5	0.8	0.9	-0.7	0.6
Locomotor testing rearing	0.4	0.6	1.0	-0.3	0.7	-1.0
Locomotion in novel chamber	0.4	0.5	0.8	-0.5	0.9	-0.7
Locomotion in novel chamber post-restriction	0.1	0.2	0.2	0.3	0.4	-0.5
Fecal boli incidents, locomotor time 1	0.4	0.4	0.6	-0.8	0.5	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.4	0.1	0.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.4	-0.6	0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	0.3	-0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.5	0.4	-0.2
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.4	0.4	0.2
Distance moved, locomotor task time 1	0.2	0.2	0.4	0.4	0.0	-0.7
Vertical activity count, locomotor time 1	0.3	0.3	0.6	0.8	-0.4	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.2	0.2	0.0
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.0	-0.1	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.0	-0.0	-0.1
Rest time, locomotor task time 2	0.0	0.0	0.0	0.1	-0.2	0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.4	0.0	-0.0
Vertical activity count, locomotor time 2	0.3	0.3	0.4	0.6	-0.5	0.5
Light reinforcement 1	0.1	0.2	0.3	0.5	-0.2	0.5
Light reinforcement 2	0.4	0.5	0.6	0.6	-0.7	0.8
Bone: marrow area	1.3	2.9	4.5	-2.1	1.8	-1.0
Bone: maximum diameter	4.5	8.2	12.4	-3.5	2.9	-2.0
Bone: maximum force	4.4	7.6	11.0	-3.3	3.0	-1.7
Bone: maximum moment	4.4	7.5	11.1	-3.3	3.0	-1.7
Mean time between licks in bursts	0.8	1.2	1.7	0.6	-1.2	1.3
Mean num. licks in bursts	0.2	0.2	0.4	-0.4	0.6	-0.2
Cd content in liver	2.8	3.1	3.7	1.6	-1.7	1.9
Co content in liver	0.1	0.1	0.2	0.3	-0.1	0.4
Cu content in liver	0.3	0.4	0.5	-0.6	0.7	-0.5
Fe content in liver	0.0	0.0	0.0	0.1	-0.2	0.1
K content in liver	0.7	0.7	0.8	-0.8	0.9	-0.8
Mg content in liver	1.8	1.9	2.5	-1.1	1.4	-1.6
Mn content in liver	0.2	0.2	0.4	-0.5	0.6	-0.4
Na content in liver	4.9	5.2	5.2	-2.3	2.3	-2.3
Rb content in liver	0.1	0.1	0.1	0.4	-0.1	-0.4
Se content in liver	0.0	0.0	0.1	0.2	-0.1	-0.3
Sr content in liver	1.0	0.9	1.9	1.4	-0.9	0.1
Zn content in liver	0.5	0.6	0.8	-0.4	0.9	-0.9
Bone: minimum diameter	4.9	9.1	13.4	-3.7	3.1	-2.1
Time in familiar zone, hab. session 1	3.4	3.1	3.4	-1.8	1.7	-1.8
Time in novel zone, hab. session 1	5.5	5.4	5.9	2.3	-2.4	2.3
Total zone transitions, hab. session 1	0.2	0.3	0.6	0.1	0.4	-0.8
Total locomotion distance, hab. session 1	0.2	0.3	0.3	0.6	-0.6	0.4
Locomotion velocity, hab. session 1	0.1	0.2	0.2	0.4	-0.5	0.4
Time in familiar zone, hab. session 2	0.9	0.9	1.2	0.5	-1.1	1.1
Time in novel zone, hab. session 2	0.4	0.4	0.6	-0.5	0.8	-0.7
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.2	0.6	-0.7
Total locomotion distance, hab. session 2	0.2	0.2	0.4	-0.6	0.5	-0.3
Locomotion velocity, hab. session 2	0.4	0.5	0.7	-0.8	0.8	-0.6
Novel to familiar place preference ratio	0.6	0.6	1.1	0.4	-0.9	1.0
Novelty place preference	0.6	0.6	1.0	0.5	-0.9	1.0
Time in novel zone, NPP test	0.7	0.7	1.2	0.3	-0.9	1.1
Total zone transitions, NPP test	0.1	0.1	0.2	-0.3	0.5	-0.1
Total locomotion distance, NPP test	0.0	0.0	0.1	0.0	-0.0	0.4
Locomotion velocity, NPP test	0.0	0.1	0.1	0.2	0.0	0.3
Intraocular pressure	0.1	0.2	0.3	0.2	-0.4	0.5
Delta distance traveled before/after self-admin	1.3	1.4	1.6	1.1	-1.3	1.1
Delta ambulatory time before/after self-admin	1.3	1.4	1.5	1.2	-1.2	1.2
Parametrial fat weight	17.0	33.1	49.1	-7.0	5.9	-3.9
Pavlov. Cond. lever latency	0.3	0.3	0.5	0.7	-0.7	0.3
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	-0.9	0.5	-0.0
Pavlov. Cond. change in total contacts	1.3	1.4	3.2	-1.8	1.0	-0.3
Pavlov. Cond. index score	0.6	0.7	1.5	-1.2	0.8	-0.2
Pavlov. Cond. latency score	0.5	0.6	1.2	-1.1	0.7	-0.2
Pavlov. Cond. lever contacts	0.8	1.0	1.6	-1.3	1.0	-0.6
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	1.0	-0.4	-0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.8	-0.9	0.7	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.6	-1.3	0.7	-0.1
Pavlov. Cond. response bias	0.4	0.5	1.0	-1.0	0.7	-0.2
Pavlov. Cond. lever latency	0.3	0.4	1.1	1.0	-0.4	-0.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.3	-0.6	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	-0.6	0.2	0.0
Pavlov. Cond. index score	0.0	0.1	0.1	-0.3	-0.1	0.3
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.3	-0.1	0.2
Pavlov. Cond. lever contacts	0.2	0.3	0.6	-0.8	0.4	0.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	0.3	-0.1
Pavlov. Cond. intertrial magazine entries	2.8	3.6	4.5	-2.1	2.1	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.2	-0.2	0.2
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.4	-0.2	0.4
Time in closed arm before self-admin	0.1	0.1	0.4	-0.0	0.2	-0.6
Time in closed arm after self-admin	0.1	0.1	0.2	0.5	-0.4	0.3
Time in open arm before self-admin	0.6	0.7	1.0	1.0	-0.8	0.7
Time in open arm after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.1
Bone: periosteal estimation	5.4	11.1	16.2	-4.0	3.5	-2.2
Bone: periosteal perimeter	9.7	16.1	20.8	-4.6	4.1	-3.2
Bone: post-yield work	0.2	0.3	0.5	-0.7	0.2	0.5
Progressive ratio test 1 active lever presses	0.8	0.8	1.4	1.2	-0.8	0.5
Progressive ratio test 1 breakpoint	0.5	0.5	1.1	1.1	-0.6	0.2
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.0	1.0	-0.8	0.7
Progressive ratio test 2 active lever presses	0.9	0.9	1.3	-0.7	1.0	-1.1
Progressive ratio test 2 breakpoint	0.9	1.0	1.3	-0.6	1.1	-1.1
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.0	-0.0	0.1
Incentive Sensitization - Responses	2.4	2.4	2.7	-1.5	1.6	-1.5
Incentive Sensitization - Breakpoint	2.0	2.0	2.2	-1.4	1.5	-1.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.0	0.0
Progressive ratio	1.3	1.5	2.5	1.6	-1.3	0.7
Food seeking constrained by brief footshock	4.5	5.5	9.1	3.0	-2.4	1.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.5	-0.4	0.4
Retroperitoneal fat weight	27.1	89.1	130.3	-11.4	9.8	-6.4
Reaction time number correct	0.4	0.6	0.9	-1.0	0.8	-0.7
Reaction time mean minus median	0.3	0.4	0.7	-0.2	0.6	-0.9
Reaction time mean minus median AUC	1.2	1.6	2.9	-0.7	1.2	-1.7
Reaction time num false alarms	0.1	0.1	0.3	-0.2	0.1	0.5
Reaction time num false alarms AUC	0.1	0.2	0.3	-0.5	0.5	0.1
Reaction time trials correct on left	0.4	0.6	0.9	-1.0	0.8	-0.7
Reaction time trials on left	0.4	0.6	0.9	-0.9	0.7	-0.7
Reaction time mean	0.5	0.6	1.4	1.2	-0.6	-0.4
Reaction time mean AUC	0.5	0.7	1.5	1.2	-0.6	-0.4
Median of all reaction times	0.6	0.9	1.9	1.4	-0.8	-0.3
Reaction time omissions	0.1	0.2	0.3	0.5	-0.6	0.3
Reaction time false alarm rate	0.1	0.1	0.4	0.0	-0.0	0.6
Reaction time premature initiation rate	0.0	0.0	0.1	0.2	0.1	-0.3
Reaction time premature initiations	0.4	0.5	0.7	-0.6	0.7	-0.8
Std. dev. reaction times	0.2	0.2	0.5	-0.1	0.4	-0.7
Reaction time trials completed	0.4	0.6	0.9	-0.9	0.7	-0.7
Reaction time trials AUC	0.6	0.9	1.4	-1.2	0.9	-0.7
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.3	-0.3	-0.2
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.5	-0.0	-0.1
Latency to leave start box in cocaine runway	0.4	0.5	1.0	-0.5	0.3	-1.0
Latency to leave start box in cocaine runway, F	0.5	0.5	0.8	-0.7	0.6	-0.9
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.3	0.2	-0.7
Std. dev. time between licks in bursts	2.6	3.1	3.5	1.6	-1.9	1.9
Total sessions with >9 infusions	0.4	0.4	0.8	0.9	-0.5	0.4
Short access day 1 total inactive lever presses	2.4	2.7	3.1	1.5	-1.6	1.8
Short access day 10 total inactive lever presses	1.3	1.4	1.8	-1.3	1.4	-0.8
Short access day 1 total infusions	1.4	1.5	2.1	1.5	-1.1	1.1
Short access day 10 total infusions	1.3	1.4	2.4	1.5	-1.2	0.8
Short access total infusions	1.2	1.3	2.5	1.6	-1.0	0.6
Short access day 1 locomotion	0.2	0.2	0.6	0.8	-0.3	0.1
Short access day 10 total locomotion	0.5	0.6	0.9	0.9	-0.7	0.6
Short access total locomotion	0.8	0.8	2.0	1.4	-0.6	0.2
One hour access (0.3 mA shock)	0.2	0.2	0.3	0.5	-0.6	0.3
Compulsive drug intake	0.2	0.2	0.4	-0.0	-0.4	0.7
One hour access (shock baseline)	0.3	0.3	0.7	0.8	-0.5	0.2
Social response proportion	0.4	0.4	1.1	0.3	-0.4	1.0
Social responses	1.1	1.4	2.3	-1.5	1.2	-0.7
Social time	0.3	0.4	0.5	-0.6	0.6	-0.7
Soleus weight	3.2	9.5	11.2	-3.1	3.4	-2.7
Bone: stiffness	1.7	2.7	4.2	-2.1	1.8	-0.9
Tibialis anterior weight	0.2	0.7	1.3	-1.1	0.8	-0.5
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.1	-0.3	0.6
Time to tail flick, vehicle, after self-admin	0.7	0.8	0.9	-1.0	0.9	-0.8
Time to tail flick, test, before self-admin	0.4	0.4	1.1	1.0	-0.4	0.1
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	-0.0	0.1
Delta time to tail flick, vehicle, before/after SA	5.0	4.9	5.8	-2.0	2.2	-2.4
Delta time to tail flick, test, before/after SA	0.7	0.6	1.7	-1.3	0.5	-0.0
Tibia length	0.1	0.4	0.7	-0.8	0.7	-0.3
Ambulatory time before self-admin	0.2	0.2	0.6	0.0	0.4	-0.8
Ambulatory time after self-admin	1.3	1.4	2.7	1.6	-1.2	0.5
Bone: tissue strength	0.2	0.2	0.2	0.5	-0.5	0.2
Total heroin consumption	6.7	7.9	8.6	-2.9	2.8	-2.7
Bone: trabecular number	0.5	0.8	1.7	-1.3	0.9	-0.1
Bone: trabecular spacing	2.9	3.7	4.4	2.0	-2.1	1.7
Bone: trabecular thickness	9.8	11.7	15.2	-3.9	3.6	-2.6
Bone: trabecular tissue density	2.3	3.2	3.7	1.9	-1.8	1.6
Water consumed over 24 hours	0.1	0.1	0.2	-0.3	0.5	-0.2
Number of responses in last shaping day	1.1	1.1	1.7	1.3	-1.0	0.9