Hub : Genes

Kif3c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Kif3c 0.03 0.02 1.8e-04 0.02 0.03 0.02 0.02 1.4e-04 8.1e-05 1.3e-04 1.4e-04
2 PL gene expression Kif3c 0.04 0.07 2.0e-03 0.03 0.02 0.03 0.02 8.3e-04 2.8e-03 5.6e-04 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.03.84.0-2.01.9
Area under the delay curve0.00.00.0-0.10.2
BMI with tail2.06.87.02.6-2.6
BMI without tail1.26.36.42.5-2.5
Body weight2.08.78.83.0-2.9
Weight adjusted by age0.00.00.10.2-0.2
Bone surface0.30.50.6-0.80.7
Bone volume0.91.82.0-1.41.3
Breakpoint value in progressive ratio session0.50.91.0-0.91.0
Number of licking bursts0.61.71.71.3-1.3
Context. condit. distance diff. score0.30.40.5-0.60.7
Locomotion velocity, session 10.60.70.70.8-0.8
Locomotion distance, session 10.30.40.5-0.70.6
Locomotion velocity, session 20.00.00.10.2-0.2
Locomotion distance, session 20.10.10.10.2-0.3
Locomotion velocity, session 30.00.00.0-0.10.2
Locomotion distance, session 30.00.10.10.2-0.2
Stereotopy head waving bouts, day 32.12.62.6-1.61.6
Stereotopy head waving duration, day 30.60.70.8-0.80.9
Locomotion velocity, session 70.00.00.00.1-0.0
Locomotion distance, session 70.81.01.01.0-1.0
Stereotopy head waving bouts, day 70.00.00.00.1-0.1
Stereotopy head waving duration, day 70.30.40.4-0.60.6
Locomotion velocity, session 80.40.50.5-0.70.7
Locomotion distance, session 80.30.40.5-0.60.7
Degree of sensitization distance0.70.80.80.9-0.9
Degree of sensitization stereotypy0.30.30.30.6-0.6
Conditioned locomotion2.93.43.6-1.91.8
Cocaine response after cond. corrected0.10.10.2-0.40.4
Cocaine response after cond. not corrected0.50.70.8-0.90.9
Cocaine response before conditioning2.42.93.0-1.71.7
Saline control response1.11.61.6-1.31.2
Bone: connectivity density1.32.02.2-1.51.4
Bone: cortical apparent density0.00.00.0-0.20.2
Bone: cortical area0.00.00.00.2-0.1
Bone: cortical porosity3.43.73.8-1.91.9
Bone: cortical porosity2.93.23.3-1.81.8
Bone: cortical thickness0.20.40.40.6-0.6
Bone: cortical thickness0.30.30.3-0.60.6
Bone: cortical tissue density0.00.00.0-0.10.1
Condit. Reinf. active minus inactive responses2.12.32.51.6-1.5
Condit. Reinf. active-inactive response ratio1.81.92.21.5-1.3
Condit. Reinf. active responses0.10.20.20.4-0.4
Condit. Reinf. inactive responses0.91.21.3-1.11.0
Incentive salience index mean0.20.30.30.5-0.5
Condit. Reinf. lever presses0.81.21.2-1.11.1
Condit. Reinf. active minus inactive responses0.71.11.2-1.11.0
Condit. Reinf. active-inactive response ratio0.30.50.6-0.80.7
Condit. Reinf. active responses0.40.60.7-0.80.8
Condit. Reinf. inactive responses0.10.10.1-0.30.4
Condit. Reinf. lever presses0.91.31.3-1.11.1
Condit. Reinf. lever reinforcers received0.40.60.7-0.80.8
Conditioned reinforcement - actives1.45.76.0-2.42.3
Conditioned reinforcement - inactives2.56.87.0-2.62.6
Conditioned locomotion1.62.32.6-1.61.4
Patch foraging indifference point 0 sec0.30.80.90.9-0.9
Patch foraging indifference point AUC0.00.00.00.0-0.1
Delay disc. indifference point, 0s delay0.91.01.30.8-1.1
Delay disc. indifference point, 16s delay0.00.00.00.10.2
Delay disc. indifference point, 2s delay0.10.10.10.3-0.2
Delay disc. indifference point, 24s delay1.62.52.5-1.61.6
Delay disc. indifference point, 4s delay0.10.10.10.3-0.3
Delay disc. indifference point, 8s delay0.00.00.0-0.10.2
Indifference point function ln k0.72.22.3-1.51.5
Indifference point function log k0.72.22.3-1.51.5
Patch foraging total patch changes 0 sec0.30.80.80.9-0.9
Patch foraging total patch changes 12 sec1.01.31.31.1-1.1
Patch foraging total patch changes 18 sec0.61.31.31.1-1.2
Patch foraging total patch changes 24 sec0.51.81.81.3-1.3
Patch foraging total patch changes 6 sec1.72.92.91.7-1.7
Patch foraging time to switch 0 sec0.10.50.60.7-0.6
Patch foraging water rate 0 sec0.51.71.9-1.41.3
Patch foraging water rate 12 sec0.00.10.10.3-0.2
Patch foraging water rate 18 sec0.61.41.4-1.11.2
Patch foraging water rate 24 sec0.10.10.10.3-0.4
Patch foraging water rate 6 sec0.20.20.3-0.50.5
Seeking ratio, delayed vs. immediate footshock0.00.10.10.2-0.2
Distance traveled before self-admin0.00.10.1-0.30.2
Distance traveled after self-admin0.61.11.21.0-1.1
Extensor digitorum longus weight2.18.58.7-3.02.9
Bone: elastic displacement1.31.61.6-1.31.3
Bone: elastic work0.40.60.6-0.70.8
Bone: endosteal estimation0.10.20.2-0.40.4
Bone: endosteal perimeter0.00.00.0-0.10.1
Epididymis fat weight11.055.656.37.5-7.4
Delta time in closed arm before/after self-admin0.00.00.00.2-0.1
Delta time in open arm before/after self-admin0.00.00.00.1-0.0
Diff in mean of infusions in LGA sessions0.00.10.10.3-0.2
Delay discount exponential model param0.10.20.20.3-0.5
Extinction: sum of active levers before priming0.50.81.0-0.81.0
Active lever presses in extinction session 62.32.32.4-1.51.6
Bone: final force0.00.00.00.1-0.1
Bone: final moment0.00.00.00.1-0.1
Food consumed during 24 hour testing period0.00.10.10.3-0.3
Glucose0.81.31.31.2-1.2
Heart weight1.11.71.71.3-1.3
Delay discount hyperbolic model param0.00.00.00.1-0.2
Intermittent access intake day 1-15 change0.20.90.9-1.00.9
Intermittent access intake escalation0.10.30.3-0.60.6
Intermittent access intake escalation 20.00.00.0-0.10.1
Intermitt. access day 1 inactive lever presses0.11.51.5-1.21.2
Intermitt. access day 15 inactive lever presses0.41.92.1-1.31.5
Intermitt. access escalation Index1.85.75.72.4-2.4
Intermittent access day 1 total infusions1.23.63.8-1.81.9
Intermittent access day 15 total infusions1.33.23.3-1.81.8
Intermittent access terminal intake (last 3 days)2.54.34.4-2.12.1
Intermittent access total infusions4.35.15.2-2.22.3
Intermittent access day 1 locomotion1.63.03.2-1.81.7
Intermittent access day 15 total locomotion0.00.00.1-0.30.2
Intermittent access total locomotion1.21.51.6-1.31.2
Intermittent access standard deviation0.41.92.0-1.41.3
Left kidney weight0.10.91.0-0.91.0
Right kidney weight0.00.10.10.3-0.3
Cocaine induced anxiety0.00.10.1-0.20.3
Post-drug Anxiety1.41.61.71.3-1.2
Baseline Anxiety2.44.04.02.0-2.0
Tail length0.00.00.1-0.10.2
Length with tail0.00.10.20.4-0.3
Length without tail0.00.00.0-0.10.2
Times rat made contact with spout0.50.60.7-0.80.7
Lifetime Intake4.55.65.6-2.42.4
Liver weight, left1.73.03.01.7-1.7
Liver weight, right3.15.35.52.3-2.3
Locomotor activity0.50.80.90.9-0.9
Locomotor testing distance0.20.50.50.7-0.7
Locomotor testing rearing0.10.50.6-0.70.7
Locomotion in novel chamber0.10.10.10.2-0.3
Locomotion in novel chamber post-restriction1.23.74.01.9-2.0
Fecal boli incidents, locomotor time 11.23.03.1-1.71.7
Change in fecal boli incidents, locomotor task3.13.33.51.9-1.7
Time >=10cm from walls, locomotor time 10.40.50.5-0.70.7
Bouts of movement, locomotor time 10.00.00.00.1-0.1
Total resting periods, locomotor time 10.00.00.00.0-0.1
Rest time, locomotor task time 10.20.30.40.5-0.6
Distance moved, locomotor task time 10.00.00.10.3-0.0
Vertical activity count, locomotor time 10.00.00.00.2-0.1
Time >=10cm from walls, locomotor time 20.71.92.1-1.41.3
Bouts of movement, locomotor time 20.10.40.50.7-0.5
Total resting periods, locomotor time 20.10.40.50.7-0.6
Rest time, locomotor task time 20.00.00.00.0-0.2
Distance moved, locomotor task time 20.00.00.0-0.00.1
Vertical activity count, locomotor time 20.10.20.2-0.40.4
Light reinforcement 10.21.01.2-0.91.1
Light reinforcement 20.61.51.5-1.21.2
Bone: marrow area0.10.20.2-0.40.4
Bone: maximum diameter0.00.00.0-0.00.0
Bone: maximum force0.00.00.0-0.10.1
Bone: maximum moment0.00.00.0-0.10.2
Mean time between licks in bursts0.32.02.01.4-1.4
Mean num. licks in bursts0.72.02.1-1.41.4
Cd content in liver0.00.00.10.2-0.1
Co content in liver5.46.36.5-2.52.6
Cu content in liver0.40.40.5-0.60.7
Fe content in liver1.92.42.4-1.61.5
K content in liver0.10.10.10.4-0.3
Mg content in liver0.00.00.0-0.10.1
Mn content in liver0.60.70.70.8-0.8
Na content in liver2.22.52.5-1.61.6
Rb content in liver0.10.10.10.3-0.2
Se content in liver0.10.10.10.3-0.4
Sr content in liver0.10.10.1-0.20.3
Zn content in liver0.40.50.50.7-0.6
Bone: minimum diameter0.40.80.90.9-0.8
Time in familiar zone, hab. session 10.60.70.70.8-0.8
Time in novel zone, hab. session 10.20.30.30.5-0.5
Total zone transitions, hab. session 10.10.20.2-0.40.4
Total locomotion distance, hab. session 10.71.01.0-1.01.0
Locomotion velocity, hab. session 11.31.91.9-1.41.4
Time in familiar zone, hab. session 20.30.30.30.6-0.5
Time in novel zone, hab. session 20.00.00.00.1-0.2
Total zone transitions, hab. session 20.20.20.20.4-0.5
Total locomotion distance, hab. session 20.20.30.30.5-0.6
Locomotion velocity, hab. session 20.10.10.10.4-0.4
Novel to familiar place preference ratio0.30.40.50.6-0.7
Novelty place preference0.60.80.90.8-1.0
Time in novel zone, NPP test0.60.70.80.8-0.9
Total zone transitions, NPP test0.81.21.2-1.11.1
Total locomotion distance, NPP test1.21.71.7-1.31.3
Locomotion velocity, NPP test1.62.32.4-1.51.5
Intraocular pressure3.86.26.72.4-2.6
Delta distance traveled before/after self-admin2.12.32.41.5-1.5
Delta ambulatory time before/after self-admin0.30.50.60.7-0.7
Parametrial fat weight19.445.747.26.9-6.7
Pavlov. Cond. lever latency0.50.60.60.8-0.7
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.1
Pavlov. Cond. change in total contacts0.10.10.1-0.20.2
Pavlov. Cond. index score0.10.10.1-0.30.2
Pavlov. Cond. latency score0.00.00.0-0.20.1
Pavlov. Cond. lever contacts0.50.60.6-0.80.7
Pavlov. Cond. magazine entry number0.00.00.00.2-0.1
Pavlov. Cond. intertrial magazine entries2.12.52.7-1.51.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.5-0.70.6
Pavlov. Cond. response bias0.70.91.0-1.00.9
Pavlov. Cond. lever latency0.50.70.70.8-0.8
Pavlov. Cond. magazine entry latency0.00.10.10.2-0.2
Pavlov. Cond. change in total contacts0.00.00.0-0.10.1
Pavlov. Cond. index score0.20.30.3-0.50.5
Pavlov. Cond. latency score0.20.30.3-0.60.5
Pavlov. Cond. lever contacts0.30.40.4-0.60.6
Pavlov. Cond. magazine entry number0.10.20.2-0.40.4
Pavlov. Cond. intertrial magazine entries1.43.13.21.8-1.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.20.2
Pavlov. Cond. response bias0.40.50.6-0.70.7
Time in closed arm before self-admin0.30.50.70.5-0.8
Time in closed arm after self-admin1.01.11.30.9-1.2
Time in open arm before self-admin0.00.00.1-0.00.3
Time in open arm after self-admin0.20.20.3-0.40.5
Bone: periosteal estimation0.10.20.2-0.50.5
Bone: periosteal perimeter0.00.00.0-0.10.1
Bone: post-yield work1.62.72.8-1.61.7
Progressive ratio test 1 active lever presses2.03.53.6-1.81.9
Progressive ratio test 1 breakpoint2.13.63.8-1.81.9
Progressive ratio test 1 inactive lever presses2.56.56.7-2.52.6
Progressive ratio test 2 active lever presses2.63.73.8-1.92.0
Progressive ratio test 2 breakpoint2.73.53.6-1.81.9
Progressive ratio test 2 inactive lever presses1.44.54.6-2.12.1
Incentive Sensitization - Responses1.13.03.1-1.71.8
Incentive Sensitization - Breakpoint1.02.32.4-1.51.5
Sum of active levers in priming session hrs 5-60.10.10.10.3-0.2
Progressive ratio0.00.00.00.1-0.2
Food seeking constrained by brief footshock14.317.818.1-4.24.3
Seeking ratio, punishment vs. effort1.02.32.3-1.51.5
Retroperitoneal fat weight32.4145.0147.812.2-11.9
Reaction time number correct0.10.20.3-0.50.4
Reaction time mean minus median0.00.00.00.2-0.1
Reaction time mean minus median AUC0.00.20.20.5-0.3
Reaction time num false alarms1.32.22.21.5-1.5
Reaction time num false alarms AUC1.12.42.51.6-1.6
Reaction time trials correct on left0.10.20.3-0.50.4
Reaction time trials on left0.10.20.2-0.50.4
Reaction time mean0.00.10.10.3-0.2
Reaction time mean AUC0.00.00.00.2-0.1
Median of all reaction times0.00.00.00.2-0.1
Reaction time omissions0.10.20.30.5-0.4
Reaction time false alarm rate2.23.03.11.8-1.7
Reaction time premature initiation rate0.10.10.10.3-0.4
Reaction time premature initiations0.00.00.00.0-0.1
Std. dev. reaction times0.10.40.40.6-0.6
Reaction time trials completed0.10.20.2-0.50.4
Reaction time trials AUC0.10.20.3-0.50.4
Run reversals in cocaine runway, females0.50.50.6-0.80.7
Run reversals in cocaine runway, males0.80.80.9-0.90.9
Latency to leave start box in cocaine runway0.40.60.7-0.70.8
Latency to leave start box in cocaine runway, F0.10.10.1-0.10.3
Latency to leave start box in cocaine runway, M0.70.70.7-0.80.8
Std. dev. time between licks in bursts0.61.11.21.0-1.1
Total sessions with >9 infusions2.22.82.9-1.71.6
Short access day 1 total inactive lever presses3.16.16.4-2.52.4
Short access day 10 total inactive lever presses0.11.01.1-1.01.0
Short access day 1 total infusions2.44.74.7-2.22.1
Short access day 10 total infusions3.25.35.3-2.32.3
Short access total infusions2.33.23.3-1.81.8
Short access day 1 locomotion1.62.72.9-1.71.6
Short access day 10 total locomotion0.52.12.3-1.51.4
Short access total locomotion0.91.41.6-1.31.1
One hour access (0.3 mA shock)2.42.93.1-1.71.7
Compulsive drug intake2.23.23.41.7-1.8
One hour access (shock baseline)2.77.17.1-2.72.7
Social response proportion0.00.00.0-0.10.2
Social responses0.20.20.30.5-0.4
Social time0.00.00.0-0.20.2
Soleus weight2.88.48.5-2.92.9
Bone: stiffness0.00.00.00.2-0.2
Tibialis anterior weight0.82.93.0-1.71.7
Time to tail flick, vehicle, before self-admin0.00.00.0-0.10.1
Time to tail flick, vehicle, after self-admin3.06.16.32.4-2.5
Time to tail flick, test, before self-admin0.10.20.2-0.50.3
Time to tail flick, test, after self-admin1.51.61.6-1.31.2
Delta time to tail flick, vehicle, before/after SA2.12.32.31.5-1.5
Delta time to tail flick, test, before/after SA2.22.72.7-1.61.6
Tibia length0.72.02.11.5-1.3
Ambulatory time before self-admin0.00.10.1-0.40.3
Ambulatory time after self-admin0.20.30.40.5-0.6
Bone: tissue strength0.60.70.70.8-0.8
Total heroin consumption2.32.72.8-1.61.7
Bone: trabecular number2.03.83.8-2.01.9
Bone: trabecular spacing0.50.80.90.9-0.9
Bone: trabecular thickness0.30.40.4-0.70.6
Bone: trabecular tissue density0.20.30.3-0.50.6
Water consumed over 24 hours0.20.40.40.5-0.6
Number of responses in last shaping day1.41.91.9-1.31.4