Hub : Genes

RGD1565766

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	RGD1565766	0.07	0.09	9.3e-03	0.02	0.01	-0	0.01	4.6e-02	1.1e-01	3.5e-01	9.3e-02
2	Brain	gene expression	RGD1565766	0.1	0.08	3.0e-06	0.05	0.05	0.07	0.05	1.4e-05	1.4e-05	5.3e-07	2.1e-05
3	Adipose	gene expression	RGD1565766	0.23	0.14	3.8e-12	0.1	0.1	0.07	0.1	3.4e-11	3.2e-11	1.3e-08	5.2e-11
4	Liver	gene expression	RGD1565766	0.39	0.25	1.4e-10	0.07	0.07	0.08	0.07	1.2e-08	5.2e-08	1.4e-09	3.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.6	4.3	4.9	-2.2	-2.1	2.1	-1.9
Area under the delay curve	0.0	0.1	0.2	-0.0	-0.0	-0.2	0.4
BMI with tail	2.5	8.2	15.6	4.0	3.0	-2.2	1.8
BMI without tail	0.6	1.1	3.2	1.8	0.8	-0.7	0.5
Body weight	2.0	8.2	17.7	4.2	3.1	-2.0	1.1
Weight adjusted by age	0.4	0.5	1.5	1.2	0.6	-0.2	0.1
Bone surface	0.4	0.6	0.9	-0.9	-0.4	1.0	-0.8
Bone volume	1.3	2.3	2.6	-1.6	-1.3	1.6	-1.5
Breakpoint value in progressive ratio session	1.5	1.7	3.3	-1.4	-1.8	0.9	-0.8
Number of licking bursts	1.6	1.9	3.0	1.7	1.7	-1.0	0.9
Context. condit. distance diff. score	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.1
Locomotion velocity, session 1	0.5	0.6	0.8	0.4	0.8	-0.9	0.9
Locomotion distance, session 1	0.6	0.7	1.2	-0.8	-0.7	0.7	-1.1
Locomotion velocity, session 2	0.5	0.5	1.1	1.1	1.0	-0.0	-0.2
Locomotion distance, session 2	0.1	0.1	0.5	0.1	0.2	-0.1	-0.7
Locomotion velocity, session 3	0.0	0.1	0.2	-0.0	0.4	0.1	0.1
Locomotion distance, session 3	0.0	0.1	0.1	0.1	0.4	-0.2	0.1
Stereotopy head waving bouts, day 3	2.0	2.4	4.6	-2.1	-1.7	1.2	-0.9
Stereotopy head waving duration, day 3	0.3	0.4	1.2	-1.1	-0.6	0.4	0.1
Locomotion velocity, session 7	0.1	0.1	0.2	0.5	0.4	0.0	-0.3
Locomotion distance, session 7	0.7	0.9	1.2	0.9	1.1	-0.9	0.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.1	-0.1	-0.1	0.6
Stereotopy head waving duration, day 7	0.2	0.3	0.4	-0.5	-0.7	0.6	-0.0
Locomotion velocity, session 8	0.5	0.6	1.3	-0.4	-0.6	0.8	-1.1
Locomotion distance, session 8	0.4	0.6	1.2	-1.1	-1.0	0.5	-0.3
Degree of sensitization distance	0.6	0.6	1.1	1.0	0.7	-0.7	0.7
Degree of sensitization stereotypy	0.5	0.6	1.2	0.9	0.4	-0.5	1.1
Conditioned locomotion	2.9	3.4	4.6	-1.5	-2.0	2.1	-1.7
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.2	-0.2	0.5	-0.3
Cocaine response after cond. not corrected	0.5	0.6	0.7	-0.7	-0.6	0.9	-0.8
Cocaine response before conditioning	1.9	2.3	2.6	-1.4	-1.6	1.5	-1.6
Saline control response	1.8	2.4	4.2	-1.6	-2.1	1.3	-0.9
Bone: connectivity density	1.6	2.5	3.1	-1.6	-1.8	1.6	-1.2
Bone: cortical apparent density	0.2	0.3	0.8	-0.5	-0.9	-0.2	0.4
Bone: cortical area	0.1	0.1	0.4	0.3	0.7	-0.1	0.0
Bone: cortical porosity	3.4	3.7	6.3	-1.4	-1.3	2.2	-2.5
Bone: cortical porosity	2.7	2.9	5.4	-1.1	-1.1	1.9	-2.3
Bone: cortical thickness	0.2	0.4	0.6	0.4	0.8	-0.7	0.5
Bone: cortical thickness	0.7	0.8	1.3	-1.0	-0.7	0.7	-1.1
Bone: cortical tissue density	0.2	0.2	0.6	-0.4	-0.8	-0.2	0.4
Condit. Reinf. active minus inactive responses	2.2	2.5	3.5	1.8	1.9	-1.5	1.0
Condit. Reinf. active-inactive response ratio	2.2	2.4	3.1	1.3	1.8	-1.6	1.5
Condit. Reinf. active responses	0.2	0.3	0.6	0.8	0.6	-0.3	-0.2
Condit. Reinf. inactive responses	1.8	2.1	3.3	-1.0	-1.5	1.4	-1.8
Incentive salience index mean	0.5	0.6	1.5	1.2	1.0	-0.3	-0.3
Condit. Reinf. lever presses	0.8	1.1	2.6	-0.1	-0.7	1.2	-1.6
Condit. Reinf. active minus inactive responses	1.4	1.8	1.9	-1.2	-1.4	1.3	-1.4
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.4	-0.4	-0.6	1.1	-1.2
Condit. Reinf. active responses	1.0	1.4	1.9	-1.0	-1.4	1.1	-1.2
Condit. Reinf. inactive responses	0.3	0.4	0.7	-0.5	-0.9	0.5	-0.5
Condit. Reinf. lever presses	1.0	1.3	1.5	-1.2	-1.1	1.1	-1.1
Condit. Reinf. lever reinforcers received	0.9	1.3	1.6	-0.9	-1.3	1.0	-1.2
Conditioned reinforcement - actives	3.2	3.2	4.5	-2.1	-1.9	1.6	-1.5
Conditioned reinforcement - inactives	5.3	6.0	8.5	-2.9	-2.5	2.4	-1.9
Conditioned locomotion	4.9	5.9	7.6	-2.4	-2.4	2.1	-2.8
Patch foraging indifference point 0 sec	0.5	0.8	1.7	0.2	0.6	-1.1	1.3
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.2	0.1	0.2	0.1
Delay disc. indifference point, 0s delay	1.6	1.7	4.4	0.2	1.0	-1.2	2.1
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.1	-0.2	-0.3	0.2
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	0.0	0.4	-0.4	0.5
Delay disc. indifference point, 24s delay	4.0	3.9	5.5	-1.5	-2.1	1.8	-2.3
Delay disc. indifference point, 4s delay	0.4	0.4	1.3	-0.1	0.1	-0.6	1.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	-0.2	0.1	0.1
Indifference point function ln k	1.3	1.9	2.4	-1.5	-1.3	1.4	-1.2
Indifference point function log k	1.3	1.9	2.4	-1.5	-1.3	1.4	-1.2
Patch foraging total patch changes 0 sec	0.4	0.7	1.5	0.1	0.6	-1.0	1.2
Patch foraging total patch changes 12 sec	0.8	1.0	1.2	1.1	1.0	-0.9	1.0
Patch foraging total patch changes 18 sec	0.6	0.8	1.5	0.4	0.6	-1.1	1.2
Patch foraging total patch changes 24 sec	1.3	1.5	2.3	0.8	1.5	-1.2	1.3
Patch foraging total patch changes 6 sec	1.5	2.3	3.0	0.9	1.6	-1.6	1.7
Patch foraging time to switch 0 sec	0.4	0.6	1.0	1.0	0.1	-0.8	0.9
Patch foraging water rate 0 sec	1.7	2.7	4.3	-2.1	-1.7	1.3	-1.3
Patch foraging water rate 12 sec	0.1	0.2	0.4	-0.0	0.6	-0.4	0.4
Patch foraging water rate 18 sec	1.3	1.8	4.0	-2.0	-1.3	0.9	-0.8
Patch foraging water rate 24 sec	0.0	0.1	0.1	0.2	0.3	-0.2	0.0
Patch foraging water rate 6 sec	0.3	0.5	1.9	-1.4	-0.1	0.2	-0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	0.5	0.6	0.1	-0.1
Distance traveled before self-admin	0.1	0.2	0.3	-0.5	-0.2	0.4	-0.4
Distance traveled after self-admin	0.3	0.3	0.6	-0.3	0.8	-0.6	0.5
Extensor digitorum longus weight	2.0	7.9	10.4	-2.6	-2.5	2.8	-3.2
Bone: elastic displacement	2.0	2.2	3.4	-1.8	-1.8	1.1	-1.1
Bone: elastic work	0.7	0.9	2.2	-1.5	-1.2	0.4	-0.1
Bone: endosteal estimation	0.1	0.1	0.2	-0.5	0.0	0.4	-0.3
Bone: endosteal perimeter	0.0	0.1	0.2	0.3	0.5	0.2	-0.1
Epididymis fat weight	16.4	38.2	60.6	7.8	6.3	-5.4	4.8
Delta time in closed arm before/after self-admin	0.6	0.6	1.5	0.3	0.6	-0.6	1.2
Delta time in open arm before/after self-admin	0.5	0.5	1.6	0.5	-0.0	0.6	-1.2
Diff in mean of infusions in LGA sessions	0.3	0.3	0.7	0.8	0.3	0.5	-0.5
Delay discount exponential model param	0.0	0.0	0.0	0.1	0.2	-0.1	-0.1
Extinction: sum of active levers before priming	0.4	0.4	0.8	0.1	-0.5	0.9	-0.6
Active lever presses in extinction session 6	2.4	2.4	3.6	-0.2	-1.5	1.9	-1.9
Bone: final force	0.1	0.2	0.6	0.5	0.7	-0.0	0.2
Bone: final moment	0.1	0.1	0.4	0.4	0.6	-0.0	0.3
Food consumed during 24 hour testing period	0.1	0.2	0.5	-0.1	0.7	-0.3	0.2
Glucose	0.3	0.5	1.4	0.1	-0.0	-0.7	1.2
Heart weight	4.9	7.0	8.4	2.3	2.9	-2.6	2.7
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	0.1	0.1	-0.3
Intermittent access intake day 1-15 change	2.7	2.7	6.9	-2.6	-1.7	0.8	-0.7
Intermittent access intake escalation	1.9	1.9	5.3	-2.3	-1.3	0.4	-0.4
Intermittent access intake escalation 2	0.6	0.6	1.5	-1.2	0.0	-0.7	0.6
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	0.2	0.4	0.7	-0.5
Intermitt. access day 15 inactive lever presses	0.9	1.0	1.8	-0.8	-1.1	1.3	-0.6
Intermitt. access escalation Index	3.4	3.0	4.5	1.1	1.6	-1.9	2.1
Intermittent access day 1 total infusions	2.0	2.3	4.2	-1.2	-1.4	2.0	-1.3
Intermittent access day 15 total infusions	3.2	3.6	5.0	-2.2	-1.8	1.9	-1.6
Intermittent access terminal intake (last 3 days)	2.9	3.1	3.8	-1.9	-1.7	1.8	-1.6
Intermittent access total infusions	4.1	4.6	6.2	-1.6	-2.1	2.5	-2.2
Intermittent access day 1 locomotion	2.0	2.1	2.6	-1.5	-1.3	1.6	-1.4
Intermittent access day 15 total locomotion	0.4	0.4	0.8	-0.9	-0.7	0.5	-0.2
Intermittent access total locomotion	1.1	1.3	1.5	-1.1	-1.1	1.1	-1.2
Intermittent access standard deviation	0.5	0.6	0.9	-0.9	-0.4	0.8	-0.8
Left kidney weight	0.5	1.4	2.0	-0.5	-1.3	1.4	-1.3
Right kidney weight	0.1	0.4	1.4	1.2	0.2	-0.2	0.0
Cocaine induced anxiety	0.7	0.8	1.2	-1.1	-1.0	-0.4	0.9
Post-drug Anxiety	1.4	1.5	2.9	0.4	0.8	-1.5	1.7
Baseline Anxiety	1.6	1.7	3.5	1.3	1.9	-1.0	0.8
Tail length	0.2	0.5	0.8	-0.9	-0.6	0.6	-0.8
Length with tail	0.1	0.4	0.7	0.7	0.6	-0.2	-0.8
Length without tail	0.3	0.6	1.2	0.9	0.7	0.1	-1.1
Times rat made contact with spout	0.7	0.9	2.0	-0.8	-0.4	0.8	-1.4
Lifetime Intake	4.6	5.2	6.8	-1.8	-2.3	2.6	-2.4
Liver weight, left	0.9	1.4	2.3	1.5	1.1	-1.1	1.0
Liver weight, right	4.5	7.5	9.4	3.0	3.1	-2.6	2.3
Locomotor activity	1.2	1.8	4.4	2.1	1.6	-0.6	0.2
Locomotor testing distance	0.8	1.3	2.7	1.7	1.3	-0.6	0.6
Locomotor testing rearing	0.7	1.0	2.2	0.5	-0.4	1.2	-1.5
Locomotion in novel chamber	0.8	0.9	3.0	1.7	0.8	-0.2	-0.3
Locomotion in novel chamber post-restriction	1.9	2.3	3.6	0.8	1.2	-1.9	1.9
Fecal boli incidents, locomotor time 1	3.0	3.3	3.8	-2.0	-1.8	1.8	-1.7
Change in fecal boli incidents, locomotor task	3.6	3.4	5.9	1.3	1.3	-2.1	2.4
Time >=10cm from walls, locomotor time 1	1.2	1.2	2.0	-0.8	-1.4	0.8	-1.2
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.3	0.2	0.0	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.6	-0.2	0.1	0.0
Rest time, locomotor task time 1	0.1	0.2	0.5	-0.7	-0.2	-0.0	0.3
Distance moved, locomotor task time 1	0.4	0.4	1.1	1.1	0.7	-0.2	-0.3
Vertical activity count, locomotor time 1	0.2	0.2	0.6	0.3	0.8	-0.5	0.2
Time >=10cm from walls, locomotor time 2	1.7	1.8	2.9	-1.5	-1.7	1.1	-0.9
Bouts of movement, locomotor time 2	0.4	0.5	0.7	0.1	0.7	-0.8	0.8
Total resting periods, locomotor time 2	0.7	0.7	1.3	0.0	0.9	-1.0	1.1
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.1
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.1	-0.0	0.2	-0.1
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.4	-0.1	0.5	0.1
Light reinforcement 1	0.4	0.7	1.5	-1.2	-0.9	0.7	0.1
Light reinforcement 2	1.5	2.0	4.4	-2.1	-1.6	0.9	-0.1
Bone: marrow area	0.1	0.1	0.2	-0.5	0.0	0.4	-0.4
Bone: maximum diameter	0.0	0.0	0.0	-0.1	0.2	0.0	0.1
Bone: maximum force	0.1	0.2	0.7	0.4	0.8	-0.0	0.0
Bone: maximum moment	0.1	0.1	0.5	0.2	0.7	0.0	0.1
Mean time between licks in bursts	1.6	2.3	2.9	1.5	1.4	-1.4	1.7
Mean num. licks in bursts	1.9	2.3	4.2	-2.1	-1.6	1.0	-1.2
Cd content in liver	0.4	0.5	1.2	0.1	1.1	-0.8	-0.0
Co content in liver	4.4	5.1	6.7	-1.5	-2.6	2.5	-2.3
Cu content in liver	0.7	0.8	1.4	1.1	-0.1	0.8	-1.2
Fe content in liver	0.3	0.3	0.6	-0.8	-0.5	0.3	-0.6
K content in liver	1.9	1.9	2.8	1.6	1.7	-1.2	0.9
Mg content in liver	1.5	1.6	2.1	1.0	1.2	-1.3	1.4
Mn content in liver	0.1	0.2	0.3	0.1	0.3	-0.5	0.6
Na content in liver	2.1	2.2	4.0	-2.0	-1.7	1.2	-0.6
Rb content in liver	0.4	0.4	0.7	0.7	0.8	-0.6	0.5
Se content in liver	0.5	0.6	0.7	0.9	0.6	-0.8	0.7
Sr content in liver	0.1	0.1	0.1	0.2	0.2	-0.3	0.4
Zn content in liver	2.1	2.3	6.7	2.6	1.4	-0.6	0.4
Bone: minimum diameter	0.8	1.6	2.8	1.6	1.7	-0.7	0.8
Time in familiar zone, hab. session 1	1.2	1.2	2.1	1.5	1.4	-0.6	0.4
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.4	0.3	-0.6	0.5
Total zone transitions, hab. session 1	0.3	0.5	0.7	-0.7	-0.7	0.5	-0.9
Total locomotion distance, hab. session 1	0.8	1.1	1.3	-1.1	-1.0	0.9	-1.1
Locomotion velocity, hab. session 1	1.4	2.0	2.9	-1.7	-1.5	1.2	-1.2
Time in familiar zone, hab. session 2	0.4	0.5	0.8	0.3	0.9	-0.7	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.6	-0.1	0.1	-0.3
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.0	0.4	-0.5	-0.1
Total locomotion distance, hab. session 2	0.1	0.2	0.4	0.0	0.6	-0.6	-0.0
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.0	0.5	-0.4	-0.2
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.1	0.6	-0.7	0.3
Novelty place preference	0.4	0.5	0.8	0.3	0.9	-0.9	0.4
Time in novel zone, NPP test	0.4	0.5	1.0	0.4	1.0	-0.8	0.1
Total zone transitions, NPP test	0.8	1.2	2.4	-0.6	-0.7	1.3	-1.6
Total locomotion distance, NPP test	1.4	2.0	3.6	-1.1	-1.0	1.5	-1.9
Locomotion velocity, NPP test	1.7	2.4	2.8	-1.5	-1.5	1.6	-1.7
Intraocular pressure	2.6	3.6	5.1	1.9	1.4	-2.3	2.0
Delta distance traveled before/after self-admin	1.9	2.0	2.8	0.9	1.6	-1.4	1.7
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	0.1	0.7	-0.7	0.9
Parametrial fat weight	10.8	21.0	28.8	5.3	5.4	-3.8	3.5
Pavlov. Cond. lever latency	0.5	0.7	1.2	0.0	0.6	-1.1	1.1
Pavlov. Cond. magazine entry latency	0.1	0.2	0.6	0.8	0.2	0.1	-0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.2	-0.2	0.3	-0.2
Pavlov. Cond. index score	0.2	0.3	0.4	0.6	-0.2	0.6	-0.6
Pavlov. Cond. latency score	0.1	0.2	0.3	0.5	-0.1	0.4	-0.5
Pavlov. Cond. lever contacts	0.5	0.6	1.0	0.0	-0.9	1.0	-0.8
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	-0.4	0.1	-0.3	0.6
Pavlov. Cond. intertrial magazine entries	1.7	2.0	2.6	-1.2	-1.6	1.5	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.0	0.1	-0.7	1.0	-0.9
Pavlov. Cond. response bias	0.9	1.1	1.7	-0.4	-1.1	1.3	-1.2
Pavlov. Cond. lever latency	0.7	0.9	1.1	1.0	1.0	-1.0	0.8
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.3	-0.3	-0.2	0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	-0.2	0.2	-0.4
Pavlov. Cond. index score	0.4	0.5	0.9	-0.9	-0.7	0.5	-0.5
Pavlov. Cond. latency score	0.4	0.5	0.9	-1.0	-0.7	0.5	-0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.4	-0.5	0.6	-0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.0
Pavlov. Cond. intertrial magazine entries	2.0	2.6	4.0	1.3	1.6	-2.0	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	-0.7	-0.4	0.2	-0.3
Pavlov. Cond. response bias	0.3	0.5	0.7	-0.6	-0.9	0.7	-0.5
Time in closed arm before self-admin	0.1	0.1	0.4	-0.2	-0.2	-0.1	-0.6
Time in closed arm after self-admin	0.5	0.5	1.1	1.0	0.7	-0.6	0.1
Time in open arm before self-admin	0.2	0.2	0.4	0.3	0.6	-0.2	0.6
Time in open arm after self-admin	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.3
Bone: periosteal estimation	0.1	0.1	0.2	-0.3	0.2	0.4	-0.5
Bone: periosteal perimeter	0.1	0.1	0.3	0.2	0.5	-0.1	0.2
Bone: post-yield work	1.6	2.2	4.4	-1.0	-0.8	1.7	-2.1
Progressive ratio test 1 active lever presses	2.6	2.8	4.1	-0.7	-1.5	2.0	-2.0
Progressive ratio test 1 breakpoint	1.8	1.9	3.0	-0.6	-1.3	1.7	-1.6
Progressive ratio test 1 inactive lever presses	4.3	4.6	6.5	-1.6	-2.2	2.6	-2.2
Progressive ratio test 2 active lever presses	2.4	2.6	3.0	-1.7	-1.6	1.5	-1.5
Progressive ratio test 2 breakpoint	2.5	2.8	3.3	-1.8	-1.7	1.6	-1.6
Progressive ratio test 2 inactive lever presses	2.9	3.3	5.4	-2.3	-1.9	1.7	-1.2
Incentive Sensitization - Responses	1.8	1.8	3.2	-1.8	-1.3	1.1	-1.1
Incentive Sensitization - Breakpoint	1.2	1.2	2.5	-1.6	-1.0	0.8	-0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.2	0.1	-0.3	0.4
Progressive ratio	0.6	0.7	1.9	0.3	0.3	1.0	-1.4
Food seeking constrained by brief footshock	15.3	18.8	26.0	-2.8	-4.3	4.8	-5.1
Seeking ratio, punishment vs. effort	1.7	2.1	4.5	-1.4	-2.1	1.0	-0.8
Retroperitoneal fat weight	30.1	99.0	118.5	10.9	10.2	-9.4	9.2
Reaction time number correct	0.2	0.2	0.4	-0.3	-0.4	0.5	-0.6
Reaction time mean minus median	0.4	0.6	2.1	1.4	-0.0	0.2	-0.4
Reaction time mean minus median AUC	0.4	0.5	1.9	1.4	0.4	-0.1	-0.1
Reaction time num false alarms	1.9	2.6	4.6	2.1	2.1	-1.1	0.7
Reaction time num false alarms AUC	1.8	2.5	4.2	2.0	2.0	-1.1	0.8
Reaction time trials correct on left	0.2	0.2	0.4	-0.3	-0.4	0.5	-0.6
Reaction time trials on left	0.2	0.2	0.4	-0.2	-0.4	0.5	-0.7
Reaction time mean	0.1	0.2	0.3	0.5	-0.1	-0.3	0.6
Reaction time mean AUC	0.1	0.1	0.2	0.4	-0.2	-0.1	0.3
Median of all reaction times	0.1	0.2	0.5	-0.1	-0.2	-0.3	0.7
Reaction time omissions	0.7	0.9	2.9	1.7	0.8	-0.3	0.1
Reaction time false alarm rate	2.2	3.1	4.6	2.0	2.1	-1.5	1.2
Reaction time premature initiation rate	0.1	0.1	0.3	-0.1	-0.0	-0.5	0.3
Reaction time premature initiations	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.1
Std. dev. reaction times	0.4	0.6	2.1	1.4	0.2	-0.4	0.2
Reaction time trials completed	0.2	0.2	0.4	-0.2	-0.4	0.5	-0.7
Reaction time trials AUC	0.2	0.3	0.5	-0.2	-0.4	0.6	-0.7
Run reversals in cocaine runway, females	0.8	0.8	2.0	-1.0	-1.4	0.4	-0.3
Run reversals in cocaine runway, males	0.9	0.9	1.8	-1.3	-0.8	0.8	-0.6
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.5	-0.1	0.4	0.0
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.0	0.3	0.2	0.2
Latency to leave start box in cocaine runway, M	1.3	1.2	1.4	-1.2	-1.1	1.2	-0.9
Std. dev. time between licks in bursts	0.6	0.7	1.2	0.4	0.7	-0.9	1.1
Total sessions with >9 infusions	6.4	7.0	9.2	-1.9	-2.5	3.0	-3.0
Short access day 1 total inactive lever presses	1.7	1.9	2.7	-1.6	-1.3	1.5	-0.9
Short access day 10 total inactive lever presses	0.3	0.3	0.6	0.6	0.4	-0.1	0.7
Short access day 1 total infusions	3.8	4.0	4.9	-1.5	-2.2	2.2	-2.0
Short access day 10 total infusions	4.6	5.1	6.7	-1.9	-2.5	2.6	-1.9
Short access total infusions	3.9	4.4	5.8	-1.5	-2.3	2.4	-2.1
Short access day 1 locomotion	5.3	5.7	9.1	-1.3	-2.2	2.6	-3.0
Short access day 10 total locomotion	1.3	1.4	1.9	-1.3	-0.8	1.3	-1.4
Short access total locomotion	2.1	2.2	2.7	-1.4	-1.2	1.6	-1.7
One hour access (0.3 mA shock)	2.5	3.0	7.0	-2.6	-1.7	1.0	-1.0
Compulsive drug intake	5.6	5.6	10.4	0.5	2.3	-2.6	3.2
One hour access (shock baseline)	7.1	8.3	10.8	-2.2	-3.1	2.8	-3.3
Social response proportion	0.1	0.1	0.3	-0.2	-0.6	0.1	-0.1
Social responses	0.1	0.2	0.2	0.4	0.4	-0.4	0.4
Social time	0.2	0.3	0.8	-0.2	-0.9	0.3	-0.3
Soleus weight	2.3	6.6	9.3	-3.0	-2.6	2.4	-2.3
Bone: stiffness	0.3	0.5	1.0	0.7	1.0	-0.3	0.7
Tibialis anterior weight	0.8	2.8	4.1	-1.7	-1.2	1.6	-2.0
Time to tail flick, vehicle, before self-admin	0.9	0.9	3.1	1.8	0.5	-0.1	-0.5
Time to tail flick, vehicle, after self-admin	5.3	5.6	8.6	2.9	2.2	-2.4	1.8
Time to tail flick, test, before self-admin	1.4	1.4	2.5	-0.9	-1.0	1.2	-1.6
Time to tail flick, test, after self-admin	0.7	0.7	1.2	-0.7	-0.7	1.1	-0.9
Delta time to tail flick, vehicle, before/after SA	2.5	2.5	3.8	0.9	1.4	-1.8	1.9
Delta time to tail flick, test, before/after SA	1.2	1.0	2.1	-1.4	-1.1	1.0	-0.2
Tibia length	0.6	1.6	2.2	1.3	1.5	-1.3	0.9
Ambulatory time before self-admin	0.1	0.1	0.2	-0.2	-0.2	0.3	-0.4
Ambulatory time after self-admin	0.2	0.2	0.3	-0.4	0.6	-0.4	0.5
Bone: tissue strength	0.8	0.8	1.6	0.5	0.7	-0.9	1.3
Total heroin consumption	2.5	2.9	5.8	-2.4	-2.2	0.9	-0.6
Bone: trabecular number	2.7	4.3	4.8	-2.2	-2.0	2.2	-1.9
Bone: trabecular spacing	0.6	0.7	1.1	0.6	0.7	-1.1	1.0
Bone: trabecular thickness	0.4	0.5	0.9	-0.3	-0.6	0.9	-1.0
Bone: trabecular tissue density	0.1	0.2	0.4	-0.1	-0.3	0.4	-0.6
Water consumed over 24 hours	0.1	0.1	0.3	-0.3	0.1	0.2	-0.5
Number of responses in last shaping day	2.2	2.3	3.0	-1.4	-1.7	1.7	-1.2