Hub : Genes

Them7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Them7 0.27 0.3 2.4e-03 0.03 0.05 0.06 0.06 6.8e-02 1.9e-02 1.3e-02 1.4e-02
2 Liver intron excision ratio chr3_91813900_91833570 0.1 0.09 1.6e-10 0.08 0.08 0.07 0.08 2.9e-09 3.2e-09 9.4e-09 3.4e-09
3 Liver intron excision ratio chr3_91668585_91746652 0.09 0.07 5.7e-09 0.06 0.06 0.06 0.06 1.3e-07 1.2e-07 2.0e-07 1.8e-07
4 pVTA gene expression Them7 0.09 0.07 1.8e-04 0.09 0.09 0.08 0.08 1.6e-04 9.7e-05 1.7e-04 2.5e-04
5 Liver gene expression Them7 0.21 0.14 0.0e+00 0.17 0.17 0.17 0.17 1.3e-18 5.7e-19 6.5e-19 9.7e-19
6 Liver mRNA stability Them7 0.58 0.21 0.0e+00 0.35 0.35 0.35 0.35 4.1e-40 1.3e-40 3.5e-40 4.8e-40
7 Liver intron excision ratio chr3_91740600_91746652 0.75 0.15 0.0e+00 0.51 0.5 0.5 0.5 5.1e-65 1.7e-64 8.0e-64 3.3e-64

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.50.91.2-1.00.81.01.01.00.81.1
Area under the delay curve0.30.30.70.8-0.5-0.5-0.5-0.5-0.5-0.2
BMI with tail0.31.01.3-0.71.11.11.11.11.11.0
BMI without tail0.20.50.7-0.80.90.70.70.70.60.3
Body weight1.04.24.5-1.92.12.02.02.12.12.0
Weight adjusted by age0.00.00.10.3-0.0-0.0-0.1-0.0-0.1-0.0
Bone surface0.30.50.7-0.80.60.80.70.70.60.8
Bone volume0.81.41.9-1.11.01.21.21.21.11.4
Breakpoint value in progressive ratio session1.71.93.90.8-1.2-1.3-1.2-1.3-1.5-2.0
Number of licking bursts0.30.40.5-0.70.70.70.70.60.60.5
Context. condit. distance diff. score4.45.35.6-2.42.32.32.32.32.32.2
Locomotion velocity, session 11.61.82.31.5-1.4-1.4-1.4-1.3-1.3-1.0
Locomotion distance, session 10.20.20.30.5-0.5-0.5-0.5-0.4-0.4-0.3
Locomotion velocity, session 20.00.00.00.20.10.00.00.10.20.1
Locomotion distance, session 20.00.00.00.1-0.1-0.1-0.1-0.1-0.10.0
Locomotion velocity, session 30.10.10.3-0.30.30.40.40.40.40.5
Locomotion distance, session 30.10.10.2-0.40.30.30.30.30.20.3
Stereotopy head waving bouts, day 30.10.20.30.3-0.4-0.4-0.4-0.4-0.5-0.6
Stereotopy head waving duration, day 30.20.20.3-0.50.50.50.50.50.40.3
Locomotion velocity, session 70.10.10.2-0.20.30.30.30.30.40.5
Locomotion distance, session 70.10.10.20.2-0.4-0.4-0.4-0.4-0.4-0.3
Stereotopy head waving bouts, day 70.00.00.0-0.20.00.00.0-0.0-0.2-0.1
Stereotopy head waving duration, day 70.00.00.10.1-0.2-0.2-0.2-0.2-0.3-0.2
Locomotion velocity, session 80.20.30.4-0.20.50.50.50.50.60.6
Locomotion distance, session 82.63.84.0-2.01.92.02.02.01.92.0
Degree of sensitization distance0.40.40.40.6-0.6-0.6-0.6-0.6-0.5-0.6
Degree of sensitization stereotypy0.20.20.40.3-0.5-0.5-0.5-0.5-0.6-0.5
Conditioned locomotion5.96.98.92.3-2.5-2.6-2.6-2.6-2.6-3.0
Cocaine response after cond. corrected3.64.14.62.1-2.1-2.1-2.1-2.0-1.9-1.8
Cocaine response after cond. not corrected0.91.01.31.1-1.1-1.0-1.0-1.0-1.0-0.8
Cocaine response before conditioning5.87.07.9-2.82.72.72.72.72.52.4
Saline control response0.10.10.2-0.40.40.30.30.30.40.1
Bone: connectivity density0.60.91.1-1.10.81.01.01.00.71.0
Bone: cortical apparent density0.00.00.0-0.1-0.00.00.00.0-0.1-0.1
Bone: cortical area0.60.91.2-0.80.90.90.90.91.11.0
Bone: cortical porosity0.60.70.80.9-0.8-0.9-0.9-0.9-0.8-0.8
Bone: cortical porosity0.10.10.20.4-0.3-0.4-0.4-0.4-0.3-0.4
Bone: cortical thickness0.00.00.1-0.30.20.20.20.20.20.1
Bone: cortical thickness1.21.41.71.0-1.2-1.2-1.2-1.2-1.3-1.3
Bone: cortical tissue density0.00.00.0-0.20.00.10.10.0-0.0-0.1
Condit. Reinf. active minus inactive responses2.22.52.7-1.61.61.71.61.61.51.5
Condit. Reinf. active-inactive response ratio6.67.17.5-2.62.62.72.72.72.62.6
Condit. Reinf. active responses0.30.30.4-0.60.60.60.60.60.50.5
Condit. Reinf. inactive responses2.32.83.01.7-1.7-1.7-1.7-1.7-1.6-1.6
Incentive salience index mean1.31.61.9-1.41.31.31.31.31.21.0
Condit. Reinf. lever presses0.40.50.9-0.90.70.70.70.70.50.4
Condit. Reinf. active minus inactive responses2.32.93.3-1.61.71.71.71.71.81.6
Condit. Reinf. active-inactive response ratio5.55.86.3-2.32.52.42.42.42.52.2
Condit. Reinf. active responses1.52.12.5-1.21.51.51.51.51.61.5
Condit. Reinf. inactive responses0.00.00.00.1-0.00.00.00.00.10.1
Condit. Reinf. lever presses1.72.33.3-1.11.41.51.51.61.71.8
Condit. Reinf. lever reinforcers received1.62.32.6-1.31.51.51.51.51.61.5
Conditioned reinforcement - actives7.37.311.6-3.42.92.72.72.72.42.0
Conditioned reinforcement - inactives14.716.517.5-4.24.14.24.14.13.93.8
Conditioned locomotion5.36.36.5-2.52.52.52.52.52.52.6
Patch foraging indifference point 0 sec0.10.20.70.40.00.10.10.20.50.8
Patch foraging indifference point AUC1.11.21.51.1-1.2-1.1-1.2-1.1-1.2-0.8
Delay disc. indifference point, 0s delay0.10.10.50.30.10.20.20.30.40.7
Delay disc. indifference point, 16s delay0.50.50.80.9-0.8-0.8-0.8-0.7-0.7-0.3
Delay disc. indifference point, 2s delay0.20.20.4-0.20.40.40.40.50.50.6
Delay disc. indifference point, 24s delay0.40.40.50.4-0.7-0.7-0.7-0.7-0.7-0.5
Delay disc. indifference point, 4s delay0.30.30.60.8-0.5-0.6-0.6-0.6-0.6-0.5
Delay disc. indifference point, 8s delay0.00.00.20.40.1-0.0-0.00.00.00.1
Indifference point function ln k0.60.81.0-0.91.00.90.90.91.00.6
Indifference point function log k0.60.81.0-0.91.00.90.90.91.00.6
Patch foraging total patch changes 0 sec0.10.20.90.40.00.20.10.20.50.9
Patch foraging total patch changes 12 sec0.81.13.2-0.10.70.90.90.91.21.8
Patch foraging total patch changes 18 sec0.10.10.40.4-0.20.00.00.00.10.7
Patch foraging total patch changes 24 sec0.10.10.50.1-0.10.10.00.10.20.7
Patch foraging total patch changes 6 sec0.10.20.80.5-0.10.10.10.10.30.9
Patch foraging time to switch 0 sec0.50.70.9-0.70.80.90.90.90.90.9
Patch foraging water rate 0 sec0.00.00.10.2-0.0-0.0-0.00.00.10.4
Patch foraging water rate 12 sec0.00.00.00.2-0.2-0.2-0.2-0.2-0.2-0.1
Patch foraging water rate 18 sec0.30.40.7-0.80.70.60.60.60.50.3
Patch foraging water rate 24 sec0.10.10.10.10.30.30.30.30.30.4
Patch foraging water rate 6 sec0.10.10.10.3-0.3-0.3-0.3-0.3-0.3-0.2
Seeking ratio, delayed vs. immediate footshock0.20.30.6-0.50.40.50.40.50.50.8
Distance traveled before self-admin0.20.20.5-0.70.70.40.50.40.3-0.2
Distance traveled after self-admin0.91.01.1-0.91.11.01.01.01.10.9
Extensor digitorum longus weight0.10.50.60.8-0.7-0.7-0.7-0.7-0.5-0.6
Bone: elastic displacement0.70.80.90.8-0.9-0.9-0.9-0.9-1.0-0.9
Bone: elastic work0.00.00.0-0.00.0-0.0-0.0-0.00.00.0
Bone: endosteal estimation0.00.10.10.4-0.2-0.2-0.2-0.2-0.0-0.2
Bone: endosteal perimeter0.30.60.9-0.60.70.70.70.80.90.8
Epididymis fat weight1.53.63.8-1.81.91.91.91.91.91.9
Delta time in closed arm before/after self-admin0.00.00.10.30.00.00.10.10.20.1
Delta time in open arm before/after self-admin1.41.31.71.2-1.3-1.2-1.2-1.2-1.2-0.7
Diff in mean of infusions in LGA sessions0.00.00.0-0.10.10.10.10.10.00.1
Delay discount exponential model param0.30.40.7-0.80.50.60.60.60.60.3
Extinction: sum of active levers before priming0.10.10.6-0.40.1-0.0-0.0-0.1-0.3-0.8
Active lever presses in extinction session 60.50.51.2-1.10.70.70.70.70.60.1
Bone: final force0.20.30.5-0.40.50.50.50.60.70.7
Bone: final moment0.10.10.3-0.20.30.30.30.30.50.5
Food consumed during 24 hour testing period3.64.34.5-2.02.12.12.12.12.11.9
Glucose1.11.61.7-1.31.31.31.31.31.31.2
Heart weight0.40.60.70.5-0.8-0.8-0.8-0.8-0.8-0.8
Delay discount hyperbolic model param0.20.20.6-0.80.40.50.50.40.40.2
Intermittent access intake day 1-15 change0.70.71.0-0.71.00.90.90.90.90.5
Intermittent access intake escalation0.90.91.1-0.51.11.01.01.01.10.9
Intermittent access intake escalation 21.01.01.3-0.61.11.11.11.11.10.9
Intermitt. access day 1 inactive lever presses3.03.24.8-2.21.81.81.81.81.61.3
Intermitt. access day 15 inactive lever presses4.34.78.9-3.02.32.22.22.11.71.3
Intermitt. access escalation Index0.60.50.91.0-0.5-0.6-0.6-0.6-0.6-0.9
Intermittent access day 1 total infusions2.93.37.2-2.71.91.81.71.71.41.1
Intermittent access day 15 total infusions4.65.16.2-2.52.42.32.32.32.11.9
Intermittent access terminal intake (last 3 days)4.85.26.0-2.42.52.32.32.32.32.0
Intermittent access total infusions4.85.37.6-2.72.42.32.32.32.11.9
Intermittent access day 1 locomotion2.62.74.7-2.21.71.61.61.61.41.4
Intermittent access day 15 total locomotion1.11.22.1-1.51.11.11.11.00.90.9
Intermittent access total locomotion2.93.45.9-2.41.91.81.81.81.61.3
Intermittent access standard deviation2.52.63.4-1.81.71.71.71.61.51.1
Left kidney weight1.13.03.5-1.51.71.71.71.71.81.9
Right kidney weight1.13.03.9-1.41.71.71.71.71.92.0
Cocaine induced anxiety2.52.93.3-1.71.81.71.71.71.71.6
Post-drug Anxiety0.50.50.9-0.90.90.70.70.70.70.5
Baseline Anxiety4.75.06.82.6-2.5-2.3-2.3-2.2-2.0-1.5
Tail length0.10.30.7-0.80.70.50.50.50.40.4
Length with tail0.51.92.4-1.31.31.31.31.31.41.6
Length without tail1.02.33.9-1.01.31.51.41.51.72.0
Times rat made contact with spout0.30.40.5-0.40.60.60.60.60.70.7
Lifetime Intake4.55.16.4-2.52.32.32.32.32.12.1
Liver weight, left0.71.21.6-1.31.11.11.11.11.00.9
Liver weight, right2.54.25.1-2.32.22.12.12.12.11.6
Locomotor activity0.00.00.00.0-0.1-0.1-0.0-0.10.0-0.1
Locomotor testing distance1.52.52.8-1.71.51.61.61.61.71.5
Locomotor testing rearing0.50.80.9-0.70.80.90.90.90.90.9
Locomotion in novel chamber0.50.61.0-1.00.70.70.70.80.80.8
Locomotion in novel chamber post-restriction1.61.92.21.1-1.5-1.4-1.4-1.4-1.4-1.4
Fecal boli incidents, locomotor time 16.97.67.82.7-2.8-2.8-2.8-2.8-2.7-2.7
Change in fecal boli incidents, locomotor task2.01.92.0-1.21.41.41.41.41.41.4
Time >=10cm from walls, locomotor time 11.11.11.50.8-1.1-1.1-1.1-1.1-1.2-1.1
Bouts of movement, locomotor time 10.30.30.90.1-0.4-0.3-0.3-0.4-0.7-0.9
Total resting periods, locomotor time 10.50.61.30.3-0.6-0.6-0.6-0.7-1.0-1.1
Rest time, locomotor task time 12.83.13.92.0-1.8-1.7-1.7-1.7-1.7-1.7
Distance moved, locomotor task time 12.72.93.9-2.01.71.71.71.71.61.5
Vertical activity count, locomotor time 10.60.71.1-1.00.80.80.80.80.70.7
Time >=10cm from walls, locomotor time 22.62.73.1-1.81.71.71.61.71.61.5
Bouts of movement, locomotor time 21.61.72.0-1.21.31.41.41.41.21.3
Total resting periods, locomotor time 21.51.61.9-1.21.31.41.31.31.21.2
Rest time, locomotor task time 23.84.45.51.8-2.0-2.1-2.1-2.1-2.2-2.4
Distance moved, locomotor task time 22.83.33.5-1.71.81.81.81.81.91.8
Vertical activity count, locomotor time 23.74.05.0-1.72.02.02.02.02.12.2
Light reinforcement 10.10.20.40.00.30.40.40.40.50.6
Light reinforcement 20.71.01.21.0-0.9-1.0-1.0-1.0-0.9-1.1
Bone: marrow area0.00.10.10.4-0.2-0.2-0.2-0.2-0.0-0.2
Bone: maximum diameter0.30.50.7-0.50.70.70.70.70.90.7
Bone: maximum force0.50.91.3-0.70.90.90.90.91.11.1
Bone: maximum moment0.20.40.7-0.40.60.50.60.60.80.8
Mean time between licks in bursts0.20.30.50.5-0.5-0.5-0.5-0.5-0.6-0.7
Mean num. licks in bursts0.00.00.10.3-0.2-0.2-0.2-0.1-0.10.1
Cd content in liver0.20.20.5-0.10.40.50.50.50.60.7
Co content in liver1.82.12.91.0-1.4-1.4-1.4-1.5-1.6-1.7
Cu content in liver1.21.52.11.1-1.1-1.2-1.2-1.2-1.2-1.4
Fe content in liver0.10.20.20.5-0.4-0.4-0.4-0.4-0.4-0.2
K content in liver0.70.70.80.6-0.8-0.8-0.8-0.8-0.8-0.9
Mg content in liver0.60.70.70.7-0.8-0.8-0.8-0.8-0.8-0.8
Mn content in liver1.51.62.20.9-1.3-1.3-1.3-1.3-1.4-1.5
Na content in liver0.20.20.7-0.80.50.40.40.30.2-0.1
Rb content in liver1.01.21.61.3-1.2-1.1-1.1-1.1-1.0-0.8
Se content in liver3.84.76.11.9-2.1-2.2-2.2-2.2-2.2-2.5
Sr content in liver0.00.00.0-0.20.10.10.10.0-0.0-0.2
Zn content in liver1.61.72.21.2-1.3-1.3-1.3-1.3-1.4-1.5
Bone: minimum diameter1.32.53.2-1.31.61.61.61.61.81.6
Time in familiar zone, hab. session 11.01.01.11.0-1.0-1.0-1.1-1.0-0.9-0.7
Time in novel zone, hab. session 11.91.92.0-1.31.41.41.41.41.41.2
Total zone transitions, hab. session 12.02.73.2-1.81.61.61.61.61.51.8
Total locomotion distance, hab. session 10.40.60.9-0.90.80.80.80.70.60.7
Locomotion velocity, hab. session 10.30.40.6-0.80.60.60.60.60.50.5
Time in familiar zone, hab. session 20.20.30.30.3-0.4-0.5-0.5-0.5-0.5-0.6
Time in novel zone, hab. session 20.20.20.4-0.20.40.50.50.50.60.7
Total zone transitions, hab. session 20.40.50.7-0.90.70.70.70.70.60.6
Total locomotion distance, hab. session 20.40.60.70.5-0.7-0.8-0.8-0.8-0.8-0.8
Locomotion velocity, hab. session 20.30.40.50.4-0.6-0.7-0.7-0.7-0.7-0.7
Novel to familiar place preference ratio3.53.63.9-1.71.91.91.91.92.01.9
Novelty place preference3.73.84.1-1.82.02.02.02.02.01.9
Time in novel zone, NPP test3.13.13.4-1.61.81.81.81.81.81.7
Total zone transitions, NPP test1.82.63.01.3-1.6-1.6-1.6-1.6-1.7-1.6
Total locomotion distance, NPP test2.33.23.81.5-1.8-1.8-1.8-1.8-1.9-1.9
Locomotion velocity, NPP test2.02.83.31.4-1.7-1.7-1.7-1.7-1.8-1.8
Intraocular pressure0.20.30.40.6-0.6-0.6-0.6-0.6-0.6-0.1
Delta distance traveled before/after self-admin0.00.00.1-0.20.00.10.10.10.10.3
Delta ambulatory time before/after self-admin0.20.20.4-0.30.40.50.50.50.50.6
Parametrial fat weight0.10.30.4-0.20.50.50.50.50.60.6
Pavlov. Cond. lever latency0.20.31.01.0-0.5-0.5-0.5-0.5-0.2-0.1
Pavlov. Cond. magazine entry latency1.01.31.7-1.31.11.21.21.11.01.0
Pavlov. Cond. change in total contacts0.10.10.20.0-0.2-0.2-0.2-0.2-0.4-0.5
Pavlov. Cond. index score0.10.10.4-0.60.30.40.40.30.10.1
Pavlov. Cond. latency score0.10.20.5-0.70.40.40.40.40.20.2
Pavlov. Cond. lever contacts0.10.20.6-0.80.40.40.40.30.10.0
Pavlov. Cond. magazine entry number1.11.41.71.3-1.2-1.2-1.2-1.2-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.10.30.30.30.30.40.4
Pavlov. Cond. lever-magazine prob. diff.0.00.10.2-0.50.20.20.20.1-0.1-0.1
Pavlov. Cond. response bias0.40.51.0-1.00.70.70.70.70.50.4
Pavlov. Cond. lever latency1.92.52.81.4-1.5-1.7-1.6-1.6-1.5-1.7
Pavlov. Cond. magazine entry latency1.01.21.4-1.11.11.21.21.11.11.0
Pavlov. Cond. change in total contacts0.40.50.7-0.60.60.70.70.70.70.8
Pavlov. Cond. index score1.82.32.5-1.41.51.61.61.61.51.6
Pavlov. Cond. latency score1.72.12.3-1.41.41.51.51.51.41.5
Pavlov. Cond. lever contacts2.63.54.2-1.61.81.91.91.91.92.0
Pavlov. Cond. magazine entry number0.91.11.30.9-1.0-1.1-1.1-1.1-1.1-1.1
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.10.20.20.20.20.30.3
Pavlov. Cond. lever-magazine prob. diff.1.72.12.4-1.31.41.51.51.51.41.5
Pavlov. Cond. response bias2.63.64.2-1.61.82.01.92.01.92.0
Time in closed arm before self-admin3.64.16.1-2.52.02.12.12.01.81.6
Time in closed arm after self-admin3.13.23.4-1.61.81.81.81.81.91.6
Time in open arm before self-admin3.13.43.71.9-1.7-1.9-1.9-1.9-1.8-1.9
Time in open arm after self-admin7.17.88.32.6-2.8-2.9-2.9-2.8-2.9-2.7
Bone: periosteal estimation0.00.10.2-0.10.30.30.30.30.50.4
Bone: periosteal perimeter0.61.01.4-0.81.01.01.01.01.21.0
Bone: post-yield work0.00.00.00.1-0.1-0.1-0.1-0.1-0.00.1
Progressive ratio test 1 active lever presses2.62.74.3-2.11.71.61.61.61.41.4
Progressive ratio test 1 breakpoint2.42.53.9-2.01.71.51.51.51.31.4
Progressive ratio test 1 inactive lever presses3.23.55.5-2.32.01.91.91.91.61.3
Progressive ratio test 2 active lever presses3.43.75.9-2.42.01.91.91.91.71.4
Progressive ratio test 2 breakpoint4.14.67.4-2.72.32.22.22.11.81.6
Progressive ratio test 2 inactive lever presses7.48.610.3-3.23.03.02.92.92.72.7
Incentive Sensitization - Responses1.31.32.9-1.71.31.11.21.10.80.3
Incentive Sensitization - Breakpoint1.21.22.6-1.61.21.11.11.00.80.3
Sum of active levers in priming session hrs 5-61.81.83.90.5-1.1-1.3-1.3-1.3-1.5-2.0
Progressive ratio0.20.20.5-0.70.60.50.50.40.2-0.1
Food seeking constrained by brief footshock0.20.20.4-0.60.50.50.50.50.30.4
Seeking ratio, punishment vs. effort0.20.20.70.8-0.6-0.5-0.5-0.4-0.20.2
Retroperitoneal fat weight15.851.853.6-6.87.27.37.27.37.37.3
Reaction time number correct0.20.30.70.8-0.5-0.5-0.5-0.5-0.3-0.3
Reaction time mean minus median0.00.10.10.4-0.3-0.2-0.3-0.2-0.10.0
Reaction time mean minus median AUC0.00.00.10.4-0.2-0.2-0.2-0.2-0.00.1
Reaction time num false alarms1.92.63.31.8-1.6-1.7-1.7-1.6-1.4-1.4
Reaction time num false alarms AUC2.94.04.52.1-2.0-2.1-2.1-2.0-1.8-1.8
Reaction time trials correct on left0.20.30.70.8-0.5-0.5-0.5-0.5-0.3-0.3
Reaction time trials on left0.20.30.80.9-0.6-0.6-0.6-0.5-0.4-0.3
Reaction time mean0.10.20.3-0.10.40.40.40.40.50.6
Reaction time mean AUC0.20.30.4-0.30.50.60.60.50.60.6
Median of all reaction times0.30.40.6-0.40.60.70.70.70.70.8
Reaction time omissions0.30.30.60.8-0.6-0.6-0.6-0.6-0.5-0.4
Reaction time false alarm rate2.33.23.51.8-1.8-1.9-1.8-1.8-1.7-1.7
Reaction time premature initiation rate0.00.00.10.0-0.00.00.0-0.00.0-0.3
Reaction time premature initiations0.10.10.30.4-0.3-0.3-0.3-0.3-0.2-0.6
Std. dev. reaction times0.00.00.20.4-0.1-0.0-0.1-0.00.10.2
Reaction time trials completed0.20.30.80.9-0.6-0.6-0.6-0.5-0.4-0.3
Reaction time trials AUC0.10.20.50.7-0.4-0.4-0.4-0.3-0.2-0.2
Run reversals in cocaine runway, females1.51.42.0-1.31.41.31.31.21.00.8
Run reversals in cocaine runway, males0.10.10.2-0.1-0.3-0.2-0.3-0.3-0.4-0.4
Latency to leave start box in cocaine runway0.80.82.20.1-0.7-0.8-0.8-0.9-1.0-1.5
Latency to leave start box in cocaine runway, F0.80.91.90.2-0.8-0.9-0.9-0.9-1.0-1.4
Latency to leave start box in cocaine runway, M0.10.10.4-0.30.1-0.1-0.1-0.1-0.2-0.6
Std. dev. time between licks in bursts0.60.70.8-0.70.80.90.90.90.90.9
Total sessions with >9 infusions2.73.03.8-1.51.71.71.71.71.82.0
Short access day 1 total inactive lever presses1.11.21.4-1.11.11.11.11.11.11.2
Short access day 10 total inactive lever presses0.40.50.6-0.40.80.70.70.70.80.6
Short access day 1 total infusions6.26.68.1-2.32.52.62.62.62.62.8
Short access day 10 total infusions1.92.22.6-1.51.51.41.41.41.41.6
Short access total infusions2.73.03.3-1.81.81.71.71.71.61.7
Short access day 1 locomotion0.60.71.1-0.70.70.80.80.80.91.1
Short access day 10 total locomotion1.82.15.5-2.31.61.41.41.31.00.2
Short access total locomotion1.31.42.2-1.51.21.11.11.21.11.0
One hour access (0.3 mA shock)3.54.15.3-2.32.22.12.12.01.81.6
Compulsive drug intake2.62.73.51.6-1.6-1.6-1.6-1.6-1.7-1.9
One hour access (shock baseline)6.47.48.7-2.92.72.72.72.72.62.7
Social response proportion3.84.15.42.3-2.2-2.1-2.1-2.1-1.9-1.1
Social responses0.50.61.21.1-1.0-0.8-0.8-0.7-0.60.3
Social time7.09.310.33.2-3.2-3.1-3.1-3.1-3.0-2.6
Soleus weight0.41.11.30.9-1.1-1.1-1.1-1.1-1.1-1.1
Bone: stiffness1.01.62.3-0.91.21.21.21.21.51.5
Tibialis anterior weight1.55.35.72.3-2.4-2.3-2.3-2.3-2.2-2.1
Time to tail flick, vehicle, before self-admin0.30.40.6-0.30.50.60.60.60.60.8
Time to tail flick, vehicle, after self-admin3.63.84.3-1.92.12.02.02.01.91.8
Time to tail flick, test, before self-admin0.20.20.6-0.80.50.50.50.40.20.0
Time to tail flick, test, after self-admin1.11.11.6-1.31.11.01.01.01.01.0
Delta time to tail flick, vehicle, before/after SA1.51.41.8-1.31.31.21.21.21.11.0
Delta time to tail flick, test, before/after SA0.10.10.20.4-0.3-0.3-0.3-0.2-0.10.1
Tibia length0.10.20.30.5-0.4-0.5-0.5-0.5-0.4-0.6
Ambulatory time before self-admin0.20.20.4-0.60.60.40.50.40.30.0
Ambulatory time after self-admin1.41.52.8-1.71.31.21.21.21.00.7
Bone: tissue strength0.50.50.50.7-0.7-0.7-0.7-0.7-0.7-0.6
Total heroin consumption0.70.92.60.2-0.6-0.8-0.8-0.9-1.0-1.6
Bone: trabecular number0.50.81.2-0.90.81.00.90.90.71.1
Bone: trabecular spacing0.00.00.1-0.10.30.10.20.20.3-0.0
Bone: trabecular thickness0.20.20.4-0.40.40.50.50.50.50.7
Bone: trabecular tissue density0.81.11.31.0-1.0-1.0-1.0-1.0-1.1-1.2
Water consumed over 24 hours0.50.60.6-0.70.70.80.80.80.70.7
Number of responses in last shaping day2.12.22.6-1.61.41.51.51.51.41.5