Clip4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Clip4	0.17	0.11	4.3e-08	0.1	0.12	0.12	0.11	7.7e-06	6.3e-07	5.4e-07	1.7e-06
2	PL	gene expression	Clip4	0.06	0.04	3.7e-08	0.07	0.07	0.07	0.07	3.0e-08	2.3e-08	2.7e-08	2.0e-08
3	Adipose	mRNA stability	Clip4	0.07	0.07	2.0e-04	0.03	0.03	0.01	0.03	2.2e-04	8.0e-04	7.3e-03	2.8e-04
4	pVTA	gene expression	Clip4	0.07	0.06	1.1e-03	0.05	0.06	0.05	0.04	4.3e-03	1.6e-03	4.7e-03	4.9e-03
5	Adipose	gene expression	Clip4	0.36	0.15	0.0e+00	0.38	0.38	0.38	0.38	3.4e-44	1.1e-44	5.8e-45	4.9e-44
6	Brain	gene expression	Clip4	0.15	0.08	0.0e+00	0.21	0.2	0.2	0.2	4.5e-19	6.1e-18	4.3e-18	1.8e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	5.6	9.3	10.4	-3.0	3.1	3.2	3.1	-2.9	-3.0
Area under the delay curve	1.5	1.5	1.8	-1.2	1.3	1.3	1.2	-1.2	-1.2
BMI with tail	0.3	1.1	1.4	1.2	-1.1	-1.1	-1.0	1.1	0.9
BMI without tail	0.1	0.1	0.2	0.2	-0.4	-0.3	-0.4	0.5	0.0
Body weight	1.6	6.5	7.2	2.5	-2.6	-2.4	-2.7	2.7	2.5
Weight adjusted by age	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.4	0.5	0.3
Bone surface	2.1	3.7	4.1	-2.0	2.0	2.0	1.9	-1.9	-1.7
Bone volume	2.8	4.7	5.9	-2.2	2.2	2.4	2.1	-2.0	-2.0
Breakpoint value in progressive ratio session	0.7	0.8	1.0	-1.0	0.8	0.8	0.9	-0.7	-0.9
Number of licking bursts	0.3	0.4	0.7	-0.5	0.6	0.8	0.5	-0.5	-0.7
Context. condit. distance diff. score	0.2	0.3	0.5	0.6	-0.3	-0.5	-0.4	0.3	0.7
Locomotion velocity, session 1	0.0	0.1	0.1	0.2	-0.2	0.0	-0.3	0.3	0.3
Locomotion distance, session 1	2.0	2.6	2.8	-1.7	1.6	1.6	1.7	-1.6	-1.5
Locomotion velocity, session 2	0.1	0.1	0.4	0.0	-0.3	-0.3	-0.4	0.4	0.6
Locomotion distance, session 2	0.0	0.0	0.1	-0.4	0.1	0.2	0.1	0.0	-0.1
Locomotion velocity, session 3	0.5	0.5	0.9	-0.9	0.7	0.7	0.7	-0.7	-0.7
Locomotion distance, session 3	1.5	1.6	2.4	-1.6	1.1	1.5	1.1	-1.0	-1.2
Stereotopy head waving bouts, day 3	1.1	1.3	1.7	-1.1	1.3	1.3	1.1	-1.3	-0.9
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.1	0.2	0.1	0.1	-0.2	-0.0
Locomotion velocity, session 7	0.7	0.7	1.2	-1.1	0.8	0.7	0.8	-0.9	-0.8
Locomotion distance, session 7	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.3	0.2	0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.3	-0.1	0.0	0.1	-0.1	-0.4
Stereotopy head waving duration, day 7	0.8	0.9	1.6	-1.3	0.7	0.8	0.9	-0.8	-1.1
Locomotion velocity, session 8	0.0	0.0	0.1	-0.3	0.1	0.3	0.0	0.1	0.1
Locomotion distance, session 8	0.1	0.1	0.2	-0.4	0.4	0.1	0.4	-0.5	-0.1
Degree of sensitization distance	1.8	1.8	2.6	1.6	-1.3	-1.4	-1.3	1.1	1.3
Degree of sensitization stereotypy	0.0	0.1	0.2	-0.4	-0.2	-0.1	0.0	0.1	-0.3
Conditioned locomotion	2.4	2.8	4.3	-1.5	1.8	1.3	1.8	-2.1	-1.5
Cocaine response after cond. corrected	2.7	3.0	4.0	-1.5	1.8	2.0	1.7	-1.6	-1.9
Cocaine response after cond. not corrected	3.5	3.8	4.3	-1.7	2.0	1.9	2.0	-2.0	-2.1
Cocaine response before conditioning	0.4	0.5	0.9	-0.8	0.6	0.2	0.8	-0.9	-0.5
Saline control response	1.2	1.5	2.6	-1.6	1.1	1.4	1.1	-0.9	-1.1
Bone: connectivity density	5.4	8.5	9.5	-2.8	2.9	3.1	2.9	-2.8	-2.9
Bone: cortical apparent density	0.5	0.7	1.1	-0.5	0.9	1.0	0.8	-0.8	-0.9
Bone: cortical area	0.3	0.4	0.6	-0.7	0.6	0.5	0.8	-0.7	-0.6
Bone: cortical porosity	1.0	1.1	1.2	-1.0	1.1	1.0	1.1	-1.1	-1.1
Bone: cortical porosity	0.9	1.0	1.1	-1.0	1.0	1.0	1.0	-1.0	-1.1
Bone: cortical thickness	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.0	0.1	0.1
Bone: cortical thickness	1.1	1.2	1.8	-0.8	1.2	1.0	1.3	-1.3	-1.0
Bone: cortical tissue density	0.4	0.5	0.8	-0.3	0.8	0.9	0.6	-0.7	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.4	-0.4	-0.3	-0.5	0.5	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	-0.4	-0.2	-0.4	0.5	0.5
Condit. Reinf. active responses	0.5	0.6	0.8	-0.7	0.9	0.9	0.8	-0.8	-0.6
Condit. Reinf. inactive responses	1.5	1.7	2.2	-0.9	1.5	1.4	1.4	-1.4	-1.2
Incentive salience index mean	0.3	0.3	0.6	-0.8	0.6	0.6	0.5	-0.4	-0.4
Condit. Reinf. lever presses	1.5	2.0	3.5	-1.9	1.3	1.4	1.3	-1.2	-1.3
Condit. Reinf. active minus inactive responses	2.9	3.5	4.9	-1.3	2.0	1.7	2.0	-2.2	-1.9
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.0	-0.5	0.8	0.5	0.8	-1.0	-0.7
Condit. Reinf. active responses	2.1	3.0	4.3	-1.1	1.8	1.5	1.9	-2.1	-1.7
Condit. Reinf. inactive responses	1.5	1.9	2.5	-1.0	1.4	1.2	1.5	-1.6	-1.4
Condit. Reinf. lever presses	1.3	1.8	2.6	-0.9	1.5	1.2	1.4	-1.6	-1.3
Condit. Reinf. lever reinforcers received	1.8	2.6	3.7	-1.0	1.7	1.4	1.7	-1.9	-1.7
Conditioned reinforcement - actives	0.4	0.4	1.0	-0.5	0.7	1.0	0.4	-0.6	-0.6
Conditioned reinforcement - inactives	2.3	2.6	3.5	-1.7	1.6	1.9	1.4	-1.4	-1.5
Conditioned locomotion	0.0	0.0	0.1	0.1	-0.0	0.3	-0.3	0.1	0.1
Patch foraging indifference point 0 sec	0.1	0.2	0.5	-0.0	-0.5	-0.2	-0.5	0.7	0.6
Patch foraging indifference point AUC	1.5	1.7	2.6	-1.2	1.3	1.4	1.3	-1.1	-1.6
Delay disc. indifference point, 0s delay	0.5	0.5	0.9	0.9	-0.7	-0.8	-0.6	0.6	0.7
Delay disc. indifference point, 16s delay	1.9	1.9	2.4	-1.6	1.3	1.5	1.3	-1.2	-1.3
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.1	0.1
Delay disc. indifference point, 24s delay	5.6	5.4	6.1	-2.3	2.5	2.2	2.3	-2.5	-2.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.5	0.5	0.6	0.4	-0.4	-0.5
Delay disc. indifference point, 8s delay	1.4	1.5	1.7	-1.3	1.2	1.3	1.2	-1.1	-1.1
Indifference point function ln k	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.2	-0.1	0.4
Indifference point function log k	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.2	-0.1	0.4
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	-0.1	-0.4	-0.2	-0.4	0.5	0.4
Patch foraging total patch changes 12 sec	0.7	0.9	1.3	0.8	-1.0	-0.9	-0.9	1.2	0.9
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.3	-0.0	0.3	0.0	0.3	-0.2
Patch foraging total patch changes 24 sec	1.3	1.6	2.0	1.1	-1.3	-1.2	-1.3	1.4	1.3
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.0	0.4	-0.0
Patch foraging time to switch 0 sec	0.1	0.2	0.2	-0.4	0.3	0.2	0.4	-0.5	-0.4
Patch foraging water rate 0 sec	0.0	0.1	0.1	0.4	-0.2	-0.0	-0.3	0.3	0.2
Patch foraging water rate 12 sec	2.2	3.4	4.5	2.1	-1.7	-2.1	-1.8	1.4	1.9
Patch foraging water rate 18 sec	0.6	0.8	1.3	1.1	-0.8	-1.0	-0.8	0.5	1.0
Patch foraging water rate 24 sec	2.3	3.2	4.2	2.1	-1.9	-1.8	-1.7	1.7	1.5
Patch foraging water rate 6 sec	1.6	2.4	3.3	1.7	-1.6	-1.8	-1.5	1.3	1.5
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.6	0.5	-0.8	-0.6	-0.6	0.7	0.7
Distance traveled before self-admin	0.0	0.1	0.1	-0.1	0.4	-0.0	0.2	-0.3	-0.1
Distance traveled after self-admin	0.1	0.2	0.4	0.5	-0.4	-0.0	-0.5	0.6	0.1
Extensor digitorum longus weight	4.9	19.4	20.2	-4.5	4.4	4.5	4.5	-4.3	-4.3
Bone: elastic displacement	0.6	0.6	1.0	-0.4	0.8	0.6	1.0	-1.0	-0.8
Bone: elastic work	0.9	1.1	1.4	-0.9	1.1	0.9	1.2	-1.2	-1.0
Bone: endosteal estimation	0.2	0.4	0.7	-0.8	0.7	0.5	0.6	-0.7	-0.2
Bone: endosteal perimeter	0.1	0.2	0.4	-0.6	0.4	0.3	0.3	-0.4	-0.2
Epididymis fat weight	14.8	34.6	36.6	5.9	-5.9	-5.6	-6.0	5.9	6.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.2	-0.3	-0.2	-0.3	0.2	0.3
Delta time in open arm before/after self-admin	1.2	1.1	1.8	-1.1	0.9	1.3	1.0	-0.7	-1.3
Diff in mean of infusions in LGA sessions	0.3	0.3	0.5	-0.5	0.4	0.7	0.5	-0.2	-0.7
Delay discount exponential model param	2.3	2.4	2.8	1.6	-1.6	-1.7	-1.5	1.5	1.5
Extinction: sum of active levers before priming	0.9	0.9	1.0	-1.0	1.0	0.8	1.0	-1.0	-0.9
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.0	0.2	0.2
Bone: final force	0.1	0.2	0.3	-0.5	0.4	0.5	0.4	-0.3	-0.1
Bone: final moment	0.1	0.2	0.3	-0.5	0.4	0.5	0.4	-0.3	-0.0
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.2	0.3	0.3	0.4	-0.4	-0.4
Glucose	0.5	0.7	0.9	0.9	-0.8	-0.5	-0.9	1.0	0.7
Heart weight	10.1	14.3	14.7	3.7	-3.8	-3.7	-3.8	3.8	3.8
Delay discount hyperbolic model param	2.0	2.1	2.4	1.4	-1.5	-1.6	-1.4	1.4	1.4
Intermittent access intake day 1-15 change	0.2	0.2	0.6	0.8	-0.1	-0.5	-0.2	-0.1	0.7
Intermittent access intake escalation	0.5	0.5	1.0	1.0	-0.4	-0.8	-0.5	0.2	0.9
Intermittent access intake escalation 2	1.2	1.2	1.9	1.4	-0.8	-1.2	-1.0	0.7	1.3
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.3	0.1	0.5	-0.1	0.2	-0.1
Intermitt. access day 15 inactive lever presses	4.3	4.7	5.8	-2.4	2.2	2.2	2.2	-2.0	-2.0
Intermitt. access escalation Index	0.3	0.3	0.8	0.3	-0.7	-0.2	-0.6	0.9	0.3
Intermittent access day 1 total infusions	5.5	6.4	8.7	-2.7	2.3	3.0	2.4	-2.1	-2.7
Intermittent access day 15 total infusions	1.7	1.9	2.6	-1.3	1.5	1.6	1.3	-1.3	-1.2
Intermittent access terminal intake (last 3 days)	1.8	1.9	2.9	-1.2	1.4	1.7	1.2	-1.3	-1.4
Intermittent access total infusions	2.1	2.3	3.5	-1.5	1.5	1.9	1.4	-1.4	-1.5
Intermittent access day 1 locomotion	3.0	3.1	4.0	-1.9	1.6	2.0	1.7	-1.5	-1.9
Intermittent access day 15 total locomotion	0.6	0.6	1.2	-0.6	0.9	1.1	0.6	-0.7	-0.7
Intermittent access total locomotion	0.4	0.5	1.1	-0.6	0.6	1.0	0.5	-0.4	-0.7
Intermittent access standard deviation	0.1	0.1	0.3	0.2	-0.0	-0.2	-0.1	0.1	0.5
Left kidney weight	0.0	0.1	0.3	0.1	0.4	-0.0	0.2	-0.6	0.0
Right kidney weight	0.7	1.9	3.0	1.5	-1.1	-1.5	-1.3	1.0	1.7
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	0.2	-0.1	0.3	-0.3	-0.3
Post-drug Anxiety	0.5	0.5	0.7	0.4	-0.9	-0.8	-0.8	0.8	0.5
Baseline Anxiety	0.3	0.3	0.5	0.6	-0.6	-0.4	-0.7	0.6	0.5
Tail length	0.1	0.3	0.6	0.4	-0.6	-0.4	-0.8	0.6	0.6
Length with tail	1.2	4.5	5.6	1.9	-2.1	-1.7	-2.4	2.2	2.2
Length without tail	0.9	1.9	2.7	1.2	-1.4	-1.1	-1.4	1.5	1.6
Times rat made contact with spout	3.3	3.8	5.2	-2.3	1.9	2.2	1.8	-1.7	-1.7
Lifetime Intake	2.4	2.7	4.1	-1.7	1.5	2.0	1.5	-1.4	-1.7
Liver weight, left	2.2	3.5	4.7	1.9	-1.8	-1.7	-1.9	1.7	2.2
Liver weight, right	9.7	16.1	18.1	3.8	-4.0	-3.9	-4.1	4.0	4.3
Locomotor activity	0.1	0.1	0.3	-0.4	0.2	0.6	0.3	0.0	-0.2
Locomotor testing distance	0.8	1.4	2.0	-1.2	1.2	1.4	1.1	-0.9	-1.1
Locomotor testing rearing	0.7	1.1	1.5	-0.8	1.0	1.2	1.0	-0.8	-1.2
Locomotion in novel chamber	1.4	1.7	2.1	1.3	-1.5	-1.3	-1.3	1.4	1.2
Locomotion in novel chamber post-restriction	1.5	1.9	2.1	1.3	-1.3	-1.2	-1.4	1.5	1.4
Fecal boli incidents, locomotor time 1	0.8	0.9	1.3	-0.9	0.9	1.1	0.9	-0.9	-0.9
Change in fecal boli incidents, locomotor task	4.5	4.3	5.4	2.3	-2.0	-1.9	-2.0	2.1	1.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.5	0.4	0.3	0.2	-0.3	-0.2
Bouts of movement, locomotor time 1	4.4	4.8	5.5	-2.3	2.2	2.1	2.2	-2.3	-2.1
Total resting periods, locomotor time 1	4.2	4.6	5.5	-2.2	2.1	2.0	2.1	-2.3	-2.0
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.2	0.2	0.1	0.1	-0.2	-0.1
Distance moved, locomotor task time 1	0.6	0.7	1.1	0.8	-1.0	-0.7	-0.8	1.0	0.7
Vertical activity count, locomotor time 1	0.4	0.4	0.6	0.7	-0.7	-0.7	-0.6	0.6	0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.7	0.8	0.1	0.0	-0.1	0.0	0.1
Bouts of movement, locomotor time 2	0.2	0.2	0.5	0.7	-0.2	-0.5	-0.4	0.1	0.6
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.5	0.0	-0.2	-0.2	-0.1	0.3
Rest time, locomotor task time 2	2.1	2.4	2.8	-1.3	1.7	1.7	1.4	-1.6	-1.6
Distance moved, locomotor task time 2	1.1	1.3	1.7	1.0	-1.3	-1.2	-1.1	1.3	1.1
Vertical activity count, locomotor time 2	1.7	1.8	2.4	1.3	-1.3	-1.5	-1.2	1.1	1.5
Light reinforcement 1	4.1	7.5	8.4	-2.9	2.6	2.6	2.8	-2.5	-2.9
Light reinforcement 2	3.2	4.3	5.4	-2.3	2.1	2.0	2.1	-2.0	-1.8
Bone: marrow area	0.2	0.4	0.8	-0.9	0.7	0.6	0.6	-0.8	-0.2
Bone: maximum diameter	0.9	1.7	2.0	-1.4	1.4	1.2	1.3	-1.3	-1.2
Bone: maximum force	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	-0.0	0.2
Bone: maximum moment	0.0	0.0	0.0	-0.1	0.0	0.1	0.1	-0.1	0.1
Mean time between licks in bursts	2.8	3.9	5.0	1.9	-2.0	-2.2	-1.9	1.8	1.9
Mean num. licks in bursts	0.1	0.2	0.4	-0.7	0.4	0.4	0.4	-0.3	-0.3
Cd content in liver	0.1	0.1	0.1	0.1	0.3	0.4	0.2	-0.2	-0.2
Co content in liver	6.9	8.1	9.1	-2.8	2.8	2.7	3.0	-2.9	-2.8
Cu content in liver	0.4	0.5	1.1	-0.9	0.7	1.0	0.5	-0.4	-0.4
Fe content in liver	0.1	0.1	0.2	0.2	0.1	0.5	-0.3	0.3	0.4
K content in liver	0.4	0.4	1.0	-0.1	-0.4	-0.7	-0.6	0.4	1.0
Mg content in liver	0.3	0.3	0.9	-0.5	-0.2	-0.2	-0.5	0.5	0.9
Mn content in liver	0.1	0.1	0.3	-0.4	0.3	-0.1	0.5	-0.6	-0.1
Na content in liver	0.2	0.3	0.8	-0.9	0.5	0.5	0.4	-0.4	-0.1
Rb content in liver	0.1	0.1	0.4	-0.6	0.0	0.2	-0.1	0.0	0.1
Se content in liver	0.4	0.5	0.8	0.4	-0.8	-0.4	-0.7	0.9	0.9
Sr content in liver	0.2	0.2	0.4	0.6	-0.4	-0.6	-0.4	0.2	0.4
Zn content in liver	0.2	0.3	0.9	0.0	-0.6	-0.1	-0.5	0.9	0.3
Bone: minimum diameter	0.1	0.1	0.2	-0.2	-0.3	-0.2	-0.3	0.4	0.5
Time in familiar zone, hab. session 1	0.6	0.6	0.9	0.5	-0.8	-0.6	-0.8	1.0	0.8
Time in novel zone, hab. session 1	0.7	0.7	1.2	1.1	-0.8	-0.9	-0.8	0.8	0.7
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.1	0.3	0.1	0.3	-0.4	-0.3
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.0	0.1	-0.3	0.2	-0.3	-0.1
Locomotion velocity, hab. session 1	0.6	0.8	1.3	-0.7	0.9	0.5	1.0	-1.1	-1.0
Time in familiar zone, hab. session 2	0.1	0.1	0.4	-0.6	0.0	0.1	0.1	0.0	-0.0
Time in novel zone, hab. session 2	0.5	0.5	1.2	1.1	-0.6	-0.6	-0.7	0.6	0.6
Total zone transitions, hab. session 2	0.1	0.2	0.4	-0.7	0.4	0.1	0.4	-0.5	-0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.5	0.3	-0.0	0.4	-0.5	-0.3
Locomotion velocity, hab. session 2	0.3	0.4	0.6	-0.8	0.6	0.2	0.7	-0.8	-0.6
Novel to familiar place preference ratio	1.0	1.0	2.0	1.4	-0.9	-1.2	-0.8	0.7	0.7
Novelty place preference	1.5	1.5	2.7	1.6	-1.2	-1.4	-1.1	1.0	1.0
Time in novel zone, NPP test	1.8	1.8	2.9	1.7	-1.3	-1.5	-1.2	1.1	1.1
Total zone transitions, NPP test	1.5	2.1	2.8	-1.7	1.5	1.2	1.5	-1.5	-1.2
Total locomotion distance, NPP test	1.3	1.8	2.7	-1.3	1.4	1.0	1.4	-1.6	-1.2
Locomotion velocity, NPP test	2.9	4.1	5.2	-2.0	2.1	1.6	2.1	-2.3	-1.9
Intraocular pressure	2.8	3.9	4.9	1.9	-1.9	-1.6	-2.1	2.1	2.2
Delta distance traveled before/after self-admin	1.3	1.4	2.3	1.2	-1.3	-0.7	-1.2	1.5	1.0
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	0.5	-0.6	0.0	-0.5	0.8	0.3
Parametrial fat weight	5.3	10.4	12.3	3.1	-3.5	-3.1	-3.2	3.5	2.9
Pavlov. Cond. lever latency	2.1	2.7	4.4	2.1	-1.6	-1.7	-1.5	1.5	1.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.6	0.2	0.2	0.1	-0.1	0.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	-0.8	0.3	0.5	0.2	-0.2	0.1
Pavlov. Cond. index score	0.9	1.1	2.1	-1.4	1.0	1.0	0.9	-1.0	-0.8
Pavlov. Cond. latency score	0.8	1.0	1.9	-1.4	1.0	1.0	0.9	-0.9	-0.7
Pavlov. Cond. lever contacts	1.4	1.6	2.9	-1.7	1.2	1.2	1.2	-1.2	-1.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	0.9	-0.6	-0.5	-0.6	0.7	0.4
Pavlov. Cond. intertrial magazine entries	1.5	1.9	2.4	-1.1	1.4	1.5	1.4	-1.3	-1.5
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	3.5	-1.9	1.5	1.4	1.4	-1.5	-1.2
Pavlov. Cond. response bias	1.4	1.7	2.7	-1.7	1.3	1.2	1.3	-1.3	-1.0
Pavlov. Cond. lever latency	1.4	1.9	2.1	1.3	-1.4	-1.2	-1.4	1.4	1.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	-0.3	0.4	0.4	0.4	-0.4	-0.4
Pavlov. Cond. change in total contacts	0.4	0.6	0.8	-0.5	0.9	0.7	0.7	-0.9	-0.7
Pavlov. Cond. index score	0.5	0.7	1.0	-0.6	0.9	0.7	0.9	-1.0	-0.8
Pavlov. Cond. latency score	0.5	0.6	0.9	-0.6	0.9	0.7	0.8	-0.9	-0.7
Pavlov. Cond. lever contacts	0.6	0.8	1.0	-0.7	0.9	0.7	0.9	-1.0	-0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.3	0.2
Pavlov. Cond. intertrial magazine entries	2.7	3.5	4.0	1.9	-1.9	-2.0	-1.8	1.8	1.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.4	0.7	0.4	0.6	-0.8	-0.6
Pavlov. Cond. response bias	1.2	1.7	2.2	-1.1	1.3	1.1	1.4	-1.5	-1.3
Time in closed arm before self-admin	0.5	0.6	1.1	1.0	-0.7	-0.7	-0.7	0.7	0.7
Time in closed arm after self-admin	1.3	1.3	1.7	1.3	-1.2	-1.0	-1.2	1.2	1.1
Time in open arm before self-admin	0.1	0.1	0.2	-0.5	0.4	0.1	0.3	-0.4	-0.1
Time in open arm after self-admin	3.0	3.3	4.3	-2.1	1.8	1.8	1.8	-1.6	-1.8
Bone: periosteal estimation	0.4	0.8	1.2	-1.1	1.0	0.9	0.9	-1.0	-0.6
Bone: periosteal perimeter	0.1	0.2	0.3	-0.5	0.4	0.3	0.5	-0.5	-0.4
Bone: post-yield work	0.4	0.6	0.7	-0.8	0.7	0.8	0.8	-0.7	-0.6
Progressive ratio test 1 active lever presses	0.5	0.6	1.2	-0.8	0.7	1.1	0.6	-0.5	-0.7
Progressive ratio test 1 breakpoint	0.5	0.5	1.1	-0.7	0.7	1.1	0.6	-0.5	-0.7
Progressive ratio test 1 inactive lever presses	1.2	1.3	2.3	-1.2	1.1	1.5	1.0	-0.8	-1.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.0	0.3	0.5	-0.1	-0.1	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.1	0.4	0.5	0.0	-0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.8	1.0	1.7	-0.9	1.0	1.3	0.8	-0.8	-1.0
Incentive Sensitization - Responses	0.1	0.1	0.3	0.5	0.0	-0.2	-0.3	0.0	0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	0.7	-0.1	-0.3	-0.4	0.2	0.4
Sum of active levers in priming session hrs 5-6	1.2	1.2	1.4	-1.2	1.1	0.9	1.1	-1.1	-1.0
Progressive ratio	0.7	0.8	1.1	1.0	-0.9	-0.8	-0.9	0.9	0.9
Food seeking constrained by brief footshock	2.7	3.3	4.1	-1.6	1.9	2.0	1.7	-1.8	-1.8
Seeking ratio, punishment vs. effort	1.8	2.2	2.5	-1.4	1.5	1.6	1.5	-1.5	-1.5
Retroperitoneal fat weight	21.5	70.6	73.7	8.3	-8.6	-8.3	-8.5	8.6	8.2
Reaction time number correct	0.6	0.9	1.3	-0.4	1.1	0.9	0.9	-1.2	-0.9
Reaction time mean minus median	0.1	0.1	0.2	-0.3	0.2	0.4	0.3	-0.1	-0.4
Reaction time mean minus median AUC	0.0	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	-0.2
Reaction time num false alarms	0.4	0.5	0.8	-0.9	0.7	0.8	0.7	-0.7	-0.5
Reaction time num false alarms AUC	0.7	1.0	1.3	-1.2	1.0	1.0	1.0	-1.0	-0.8
Reaction time trials correct on left	0.6	0.9	1.3	-0.4	1.1	0.9	0.9	-1.2	-0.9
Reaction time trials on left	0.6	0.9	1.4	-0.4	1.2	1.0	0.9	-1.2	-0.9
Reaction time mean	0.3	0.4	1.1	0.4	-0.7	-0.1	-0.8	1.0	0.5
Reaction time mean AUC	0.2	0.3	0.9	0.3	-0.6	-0.0	-0.7	0.9	0.4
Median of all reaction times	0.3	0.4	1.2	0.4	-0.7	-0.1	-0.8	1.1	0.5
Reaction time omissions	0.1	0.2	0.3	-0.6	0.3	0.4	0.5	-0.2	-0.4
Reaction time false alarm rate	0.1	0.2	0.6	-0.8	0.3	0.4	0.3	-0.2	-0.2
Reaction time premature initiation rate	0.2	0.2	0.4	0.2	-0.5	-0.6	-0.5	0.5	0.5
Reaction time premature initiations	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	-0.2	0.1
Std. dev. reaction times	0.1	0.2	0.4	0.3	-0.5	-0.1	-0.5	0.6	0.3
Reaction time trials completed	0.6	0.9	1.4	-0.4	1.2	1.0	0.9	-1.2	-0.9
Reaction time trials AUC	0.9	1.2	1.9	-0.5	1.3	1.1	1.0	-1.4	-1.1
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.3	0.2	0.2	-0.0	-0.2	-0.0
Run reversals in cocaine runway, males	0.5	0.5	0.7	-0.7	0.8	0.6	0.8	-0.9	-0.6
Latency to leave start box in cocaine runway	0.5	0.5	0.7	-0.6	0.6	0.9	0.6	-0.6	-0.9
Latency to leave start box in cocaine runway, F	0.7	0.7	0.9	-0.9	0.8	0.9	0.8	-0.7	-0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.1	0.2	0.4	0.2	-0.2	-0.4
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.2	-0.2	0.0	-0.2	0.3	-0.1
Total sessions with >9 infusions	0.6	0.7	1.3	-1.0	0.7	1.1	0.8	-0.5	-0.8
Short access day 1 total inactive lever presses	3.5	3.9	5.3	-2.1	1.9	2.3	1.9	-1.5	-2.0
Short access day 10 total inactive lever presses	0.3	0.3	0.4	-0.7	0.7	0.6	0.5	-0.5	-0.5
Short access day 1 total infusions	2.2	2.3	4.0	-1.7	1.2	2.0	1.4	-0.9	-1.7
Short access day 10 total infusions	3.8	4.2	5.3	-2.1	2.0	2.3	1.9	-1.8	-2.1
Short access total infusions	1.5	1.7	2.8	-1.5	1.1	1.7	1.2	-0.9	-1.3
Short access day 1 locomotion	4.3	4.7	5.0	-2.2	2.1	2.2	2.2	-2.0	-2.1
Short access day 10 total locomotion	1.2	1.4	1.7	-1.3	1.1	1.3	1.1	-1.1	-1.2
Short access total locomotion	0.5	0.5	0.9	-0.9	0.5	0.9	0.6	-0.4	-0.7
One hour access (0.3 mA shock)	1.4	1.7	2.7	-1.4	1.3	1.6	1.1	-1.1	-1.1
Compulsive drug intake	0.4	0.4	0.6	0.5	-0.8	-0.8	-0.5	0.7	0.6
One hour access (shock baseline)	1.8	2.1	3.1	-1.5	1.5	1.8	1.2	-1.3	-1.4
Social response proportion	0.3	0.3	0.7	0.4	-0.8	-0.4	-0.6	0.8	0.3
Social responses	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.1	0.3	-0.2
Social time	0.5	0.7	1.1	0.5	-1.0	-0.7	-0.8	1.1	0.6
Soleus weight	5.7	16.7	18.1	-4.2	4.1	4.0	4.2	-4.0	-4.0
Bone: stiffness	0.0	0.1	0.2	0.2	-0.2	-0.2	-0.3	0.2	0.4
Tibialis anterior weight	4.3	14.6	15.7	-4.0	3.7	3.7	3.9	-3.7	-3.9
Time to tail flick, vehicle, before self-admin	1.5	1.6	1.8	1.3	-1.2	-1.2	-1.3	1.1	1.3
Time to tail flick, vehicle, after self-admin	3.0	3.2	3.8	1.7	-1.8	-1.8	-1.8	1.8	2.0
Time to tail flick, test, before self-admin	0.5	0.5	0.7	-0.8	0.8	0.7	0.8	-0.6	-0.6
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.2	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.2	-0.2	-0.4	-0.3	0.2	0.6
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.3	0.5	0.3	0.4	-0.7	-0.3
Tibia length	2.4	6.8	8.1	2.5	-2.6	-2.1	-2.8	2.9	2.7
Ambulatory time before self-admin	0.2	0.2	0.4	-0.4	0.6	0.2	0.5	-0.7	-0.4
Ambulatory time after self-admin	0.1	0.1	0.2	0.4	-0.2	0.1	-0.3	0.4	0.0
Bone: tissue strength	0.2	0.2	0.5	0.4	-0.6	-0.3	-0.5	0.7	0.3
Total heroin consumption	2.5	2.9	3.3	-1.8	1.8	1.5	1.8	-1.8	-1.6
Bone: trabecular number	4.8	7.4	8.6	-2.7	2.7	2.9	2.7	-2.5	-2.9
Bone: trabecular spacing	1.8	2.3	2.8	1.2	-1.6	-1.5	-1.6	1.7	1.5
Bone: trabecular thickness	0.5	0.6	0.8	-0.8	0.7	0.6	0.9	-0.8	-0.9
Bone: trabecular tissue density	0.1	0.1	0.2	-0.1	0.4	0.4	0.2	-0.4	-0.3
Water consumed over 24 hours	1.1	1.4	1.6	-1.2	1.2	1.1	1.2	-1.3	-1.0
Number of responses in last shaping day	0.0	0.0	0.1	-0.1	0.3	0.3	0.1	-0.1	0.1