Hub : Genes

Clip4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative polyA NM_001013942.1 0.04 0.04 3.5e-03 0.01 0.01 0.01 0.01 1.5e-02 4.5e-02 1.9e-02 3.1e-02
2 Brain alternative polyA XM_063261626.1 0.04 0.04 4.3e-03 0.01 0.01 0.01 0.01 1.8e-02 6.1e-02 2.5e-02 3.9e-02
3 RMTg gene expression Clip4 0.11 0.1 5.8e-03 0.07 0.08 0.08 0.08 6.2e-03 4.2e-03 3.9e-03 3.9e-03
4 BLA gene expression Clip4 0.19 0.1 6.9e-12 0.17 0.2 0.19 0.18 3.4e-09 7.8e-11 3.7e-10 8.0e-10
5 NAcc gene expression Clip4 0.03 0.02 3.8e-05 0.03 0.03 0.03 0.03 8.5e-05 3.0e-05 4.3e-05 6.0e-05
6 pVTA gene expression Clip4 0.26 0.2 1.1e-16 0.21 0.22 0.22 0.21 7.8e-17 2.2e-17 3.2e-17 4.2e-17
7 LHb gene expression Clip4 0.22 0.16 5.0e-04 0.12 0.12 0.12 0.11 1.1e-03 7.2e-04 9.9e-04 1.2e-03
8 Adipose gene expression Clip4 0.41 0.16 0.0e+00 0.41 0.41 0.41 0.41 4.2e-48 7.3e-49 1.5e-49 4.0e-49
9 IL gene expression Clip4 0.17 0.14 7.0e-03 0.05 0.02 0.04 0.03 2.7e-02 1.3e-01 4.9e-02 8.1e-02
10 PL gene expression Clip4 0.11 0.07 5.5e-14 0.13 0.13 0.13 0.13 3.8e-14 5.0e-14 1.1e-13 4.7e-14
11 OFC gene expression Clip4 0.19 0.19 4.3e-03 0.07 0.08 0.07 0.08 9.6e-03 5.6e-03 8.8e-03 5.7e-03
12 Adipose mRNA stability Clip4 0.08 0.06 1.6e-06 0.06 0.05 0.06 0.06 2.1e-07 4.5e-06 2.9e-07 4.7e-07
13 IC gene expression Clip4 0.24 0.16 1.3e-09 0.25 0.23 0.24 0.24 8.8e-11 3.3e-10 1.6e-10 1.3e-10
14 Brain gene expression Clip4 0.29 0.13 0.0e+00 0.32 0.32 0.33 0.32 4.9e-31 1.4e-30 3.0e-31 1.1e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density4.78.810.13.2-3.2-3.13.03.03.03.0-2.8-2.6-2.62.93.1-2.9-3.0
Area under the delay curve1.52.22.81.7-1.7-1.61.51.51.41.4-1.4-1.4-1.41.31.7-1.5-1.6
BMI with tail0.20.72.3-1.51.50.8-0.7-0.7-0.7-0.60.60.60.6-0.5-0.80.70.6
BMI without tail0.21.11.6-1.11.11.3-1.0-1.0-1.1-1.01.01.01.1-1.0-0.71.00.8
Body weight1.56.77.0-2.52.52.6-2.6-2.6-2.6-2.62.62.62.6-2.6-2.42.62.5
Weight adjusted by age0.00.10.1-0.20.20.2-0.3-0.3-0.3-0.30.30.20.4-0.3-0.20.20.2
Bone surface2.03.95.22.3-2.3-2.22.01.91.91.9-1.8-1.9-1.91.81.8-2.0-1.8
Bone volume2.34.66.02.4-2.4-2.32.22.22.22.1-2.0-1.9-1.92.02.1-2.1-2.1
Breakpoint value in progressive ratio session0.50.81.51.2-1.2-0.90.90.90.90.8-0.8-0.7-0.70.80.8-0.8-0.9
Number of licking bursts0.10.30.70.8-0.8-0.70.50.60.60.5-0.5-0.3-0.30.40.8-0.4-0.7
Context. condit. distance diff. score0.10.20.8-0.90.90.2-0.3-0.3-0.3-0.30.20.00.1-0.2-0.3-0.00.5
Locomotion velocity, session 10.10.10.2-0.10.10.3-0.3-0.2-0.2-0.20.40.40.4-0.3-0.30.10.3
Locomotion distance, session 12.02.63.01.7-1.7-1.61.71.71.71.7-1.5-1.6-1.61.71.3-1.7-1.4
Locomotion velocity, session 20.10.20.3-0.10.10.3-0.4-0.4-0.4-0.40.40.40.3-0.5-0.50.40.5
Locomotion distance, session 20.00.10.40.7-0.7-0.00.10.10.10.00.10.20.1-0.0-0.1-0.1-0.1
Locomotion velocity, session 30.50.50.91.0-1.0-0.70.70.70.70.6-0.7-0.7-0.70.60.7-0.7-0.7
Locomotion distance, session 31.01.22.01.4-1.4-1.01.11.11.11.0-1.0-0.8-0.80.91.1-1.2-1.2
Stereotopy head waving bouts, day 31.01.21.71.2-1.2-1.31.11.11.11.1-1.1-1.2-1.21.01.0-0.8-1.0
Stereotopy head waving duration, day 30.00.00.10.2-0.2-0.20.10.10.10.0-0.1-0.1-0.20.00.00.20.0
Locomotion velocity, session 70.80.91.81.3-1.3-0.90.90.90.90.9-0.9-0.9-0.90.80.9-1.0-0.9
Locomotion distance, session 70.00.00.10.1-0.10.1-0.2-0.2-0.2-0.30.20.20.2-0.3-0.20.30.2
Stereotopy head waving bouts, day 70.10.10.30.5-0.5-0.20.20.30.30.2-0.2-0.1-0.10.20.2-0.3-0.4
Stereotopy head waving duration, day 70.60.71.21.1-1.1-0.70.80.90.80.8-0.7-0.6-0.60.70.9-0.8-1.0
Locomotion velocity, session 80.00.00.10.3-0.3-0.0-0.00.0-0.0-0.10.10.20.2-0.20.20.2-0.0
Locomotion distance, session 80.10.20.50.2-0.2-0.40.40.40.30.4-0.5-0.6-0.60.40.1-0.7-0.2
Degree of sensitization distance1.41.52.0-1.41.41.1-1.2-1.3-1.2-1.21.21.01.0-1.1-1.31.41.3
Degree of sensitization stereotypy0.00.00.10.3-0.30.3-0.1-0.0-0.0-0.10.10.20.2-0.1-0.1-0.1-0.1
Conditioned locomotion2.22.63.41.2-1.2-1.81.71.61.61.7-1.8-1.8-1.81.71.3-1.7-1.4
Cocaine response after cond. corrected1.82.74.01.7-1.7-1.61.61.71.61.6-1.5-1.5-1.61.62.0-1.6-1.7
Cocaine response after cond. not corrected2.63.84.41.8-1.8-1.91.91.91.92.0-1.9-2.0-2.02.01.9-2.1-1.9
Cocaine response before conditioning0.60.71.20.6-0.6-0.70.90.80.80.9-1.0-1.0-1.01.00.2-1.1-0.7
Saline control response0.91.22.41.6-1.6-1.01.11.21.11.1-0.8-0.6-0.60.91.2-1.0-1.1
Bone: connectivity density4.97.89.23.0-3.0-2.92.82.82.82.8-2.6-2.5-2.42.72.9-2.7-2.8
Bone: cortical apparent density0.81.21.71.0-1.0-1.21.11.11.11.1-1.1-1.0-1.01.11.3-1.0-1.2
Bone: cortical area0.71.11.61.0-1.0-1.01.11.11.11.1-1.0-1.0-1.01.10.8-1.2-0.9
Bone: cortical porosity0.80.91.30.7-0.7-0.91.00.91.01.0-1.0-0.9-1.01.01.1-0.9-1.1
Bone: cortical porosity1.01.11.80.9-0.9-1.11.11.11.11.1-1.1-0.9-1.01.11.3-1.0-1.2
Bone: cortical thickness0.00.00.2-0.30.3-0.10.20.20.20.3-0.1-0.1-0.10.40.1-0.4-0.1
Bone: cortical thickness1.31.62.40.7-0.7-1.31.31.21.21.3-1.3-1.5-1.51.51.1-1.5-1.1
Bone: cortical tissue density0.50.91.30.8-0.8-1.00.90.90.90.9-0.9-0.9-0.90.91.2-0.8-1.0
Condit. Reinf. active minus inactive responses0.20.20.50.3-0.30.5-0.5-0.5-0.5-0.50.50.60.5-0.6-0.40.70.5
Condit. Reinf. active-inactive response ratio0.20.20.30.4-0.40.4-0.4-0.3-0.4-0.40.40.50.5-0.6-0.30.60.4
Condit. Reinf. active responses0.60.81.91.4-1.4-0.80.80.80.80.8-0.7-0.6-0.70.70.9-0.7-0.8
Condit. Reinf. inactive responses1.52.02.41.3-1.3-1.51.41.41.51.5-1.3-1.3-1.31.51.5-1.4-1.4
Incentive salience index mean0.40.62.51.6-1.6-0.60.50.60.50.5-0.4-0.3-0.40.30.8-0.3-0.5
Condit. Reinf. lever presses1.62.56.12.5-2.5-1.51.41.51.41.3-1.3-1.1-1.11.11.7-1.2-1.5
Condit. Reinf. active minus inactive responses2.33.64.81.2-1.2-2.01.91.81.92.0-2.1-2.2-2.12.11.8-2.0-1.9
Condit. Reinf. active-inactive response ratio0.40.61.10.6-0.6-0.90.80.70.70.8-0.9-1.1-1.00.80.6-0.9-0.7
Condit. Reinf. active responses2.13.14.40.9-0.9-1.91.81.71.71.9-2.0-2.1-2.02.01.6-1.8-1.7
Condit. Reinf. inactive responses1.21.82.50.5-0.5-1.41.41.31.41.4-1.5-1.6-1.61.61.2-1.4-1.3
Condit. Reinf. lever presses1.42.03.00.6-0.6-1.61.51.41.41.5-1.6-1.7-1.61.61.4-1.4-1.5
Condit. Reinf. lever reinforcers received1.92.73.70.8-0.8-1.71.71.61.61.7-1.9-1.9-1.91.91.5-1.7-1.7
Conditioned reinforcement - actives0.10.30.70.7-0.7-0.60.50.40.40.4-0.5-0.6-0.50.40.8-0.3-0.4
Conditioned reinforcement - inactives1.12.94.11.8-1.8-1.61.71.71.71.6-1.7-1.7-1.61.62.0-1.7-1.8
Conditioned locomotion0.20.30.70.1-0.10.6-0.6-0.6-0.7-0.70.60.60.6-0.8-0.10.70.5
Patch foraging indifference point 0 sec0.10.40.7-0.10.10.7-0.6-0.5-0.6-0.60.70.80.8-0.8-0.50.60.5
Patch foraging indifference point AUC0.61.42.81.1-1.1-1.11.11.21.31.2-1.0-0.8-0.71.11.7-1.2-1.5
Delay disc. indifference point, 0s delay0.70.71.7-1.31.30.9-0.8-0.8-0.8-0.70.70.70.7-0.6-0.90.70.7
Delay disc. indifference point, 16s delay1.21.72.41.6-1.6-1.31.31.31.31.2-1.1-1.0-1.01.11.5-1.3-1.4
Delay disc. indifference point, 2s delay0.00.00.00.1-0.10.1-0.0-0.0-0.0-0.00.00.0-0.1-0.10.0-0.1-0.1
Delay disc. indifference point, 24s delay3.75.96.72.5-2.5-2.62.42.42.32.4-2.4-2.6-2.62.32.3-2.4-2.4
Delay disc. indifference point, 4s delay0.20.20.50.6-0.6-0.50.40.40.40.4-0.3-0.3-0.30.30.7-0.4-0.6
Delay disc. indifference point, 8s delay1.01.72.61.6-1.6-1.31.21.31.21.2-1.1-1.2-1.21.11.4-1.4-1.3
Indifference point function ln k0.00.10.4-0.50.50.1-0.1-0.2-0.2-0.1-0.0-0.3-0.3-0.0-0.60.00.4
Indifference point function log k0.00.10.4-0.50.50.1-0.1-0.2-0.2-0.1-0.0-0.3-0.3-0.0-0.60.00.4
Patch foraging total patch changes 0 sec0.10.30.6-0.10.10.6-0.5-0.5-0.5-0.60.60.80.7-0.7-0.50.50.4
Patch foraging total patch changes 12 sec0.91.22.0-0.80.81.1-1.1-1.0-1.0-1.11.21.41.4-1.1-0.91.00.9
Patch foraging total patch changes 18 sec0.10.10.50.2-0.20.4-0.3-0.1-0.2-0.30.30.60.7-0.40.30.3-0.2
Patch foraging total patch changes 24 sec0.72.22.9-1.21.21.4-1.5-1.5-1.5-1.61.61.71.7-1.7-1.21.61.3
Patch foraging total patch changes 6 sec0.00.10.20.1-0.10.3-0.2-0.1-0.1-0.20.30.50.4-0.3-0.00.1-0.0
Patch foraging time to switch 0 sec0.00.20.30.6-0.6-0.30.40.40.40.4-0.4-0.4-0.40.40.2-0.4-0.4
Patch foraging water rate 0 sec0.00.10.2-0.50.50.3-0.3-0.3-0.3-0.30.40.40.3-0.4-0.10.40.2
Patch foraging water rate 12 sec0.73.05.6-2.42.41.6-1.7-1.8-1.8-1.71.41.21.2-1.5-2.01.41.8
Patch foraging water rate 18 sec0.40.92.4-1.51.50.7-0.8-0.9-0.9-0.80.70.50.5-0.7-1.20.81.2
Patch foraging water rate 24 sec2.53.66.7-2.62.61.9-1.8-1.8-1.8-1.71.81.81.7-1.6-1.71.71.6
Patch foraging water rate 6 sec1.52.23.2-1.81.81.5-1.5-1.5-1.5-1.51.31.11.2-1.4-1.61.41.4
Seeking ratio, delayed vs. immediate footshock0.40.60.8-0.70.70.7-0.7-0.7-0.7-0.70.80.90.8-0.7-0.80.50.8
Distance traveled before self-admin0.00.00.1-0.20.2-0.40.10.00.00.0-0.1-0.2-0.30.1-0.20.00.2
Distance traveled after self-admin0.81.42.2-1.11.11.0-1.2-1.1-1.1-1.21.31.51.4-1.2-0.81.31.0
Extensor digitorum longus weight4.719.020.73.9-3.9-4.44.54.54.54.5-4.4-4.2-4.34.54.2-4.4-4.5
Bone: elastic displacement0.60.81.20.5-0.5-0.80.80.80.91.0-0.9-1.0-1.01.10.9-1.0-0.8
Bone: elastic work1.01.41.71.3-1.3-1.11.11.11.11.2-1.1-1.2-1.21.31.0-1.3-1.0
Bone: endosteal estimation0.40.92.11.4-1.4-1.10.90.90.80.8-0.9-1.0-1.00.70.5-0.8-0.5
Bone: endosteal perimeter0.20.51.51.2-1.2-0.80.60.60.60.5-0.5-0.6-0.60.40.4-0.6-0.4
Epididymis fat weight10.753.958.5-7.07.07.6-7.5-7.5-7.5-7.57.47.37.3-7.4-7.27.27.4
Delta time in closed arm before/after self-admin0.00.00.00.1-0.10.0-0.0-0.0-0.0-0.00.0-0.10.00.00.1-0.10.0
Delta time in open arm before/after self-admin0.50.61.30.7-0.7-0.60.70.90.90.8-0.7-0.4-0.40.81.1-0.7-1.1
Diff in mean of infusions in LGA sessions0.00.10.20.3-0.3-0.10.00.10.10.10.00.20.2-0.00.40.1-0.4
Delay discount exponential model param2.43.34.1-2.02.01.9-1.8-1.8-1.7-1.71.71.71.7-1.6-2.01.81.9
Extinction: sum of active levers before priming0.81.21.51.2-1.2-1.11.11.11.11.1-1.1-1.2-1.11.01.0-1.1-1.1
Active lever presses in extinction session 60.00.00.10.0-0.0-0.0-0.1-0.00.0-0.00.20.20.2-0.0-0.4-0.00.1
Bone: final force0.20.30.60.8-0.8-0.40.50.50.50.5-0.4-0.4-0.40.40.5-0.4-0.5
Bone: final moment0.20.30.70.8-0.8-0.50.50.50.50.5-0.5-0.4-0.50.40.5-0.5-0.4
Food consumed during 24 hour testing period0.10.10.2-0.20.2-0.40.40.30.40.4-0.3-0.3-0.40.50.1-0.5-0.3
Glucose0.50.71.3-0.60.60.8-0.9-0.8-0.8-0.90.91.01.1-1.0-0.51.10.7
Heart weight2.74.45.3-1.91.92.3-2.1-2.2-2.2-2.22.12.02.0-2.1-2.02.02.2
Delay discount hyperbolic model param1.82.32.9-1.71.71.6-1.5-1.5-1.4-1.41.41.41.4-1.3-1.71.51.6
Intermittent access intake day 1-15 change0.10.51.5-1.21.20.5-0.6-0.7-0.7-0.60.4-0.00.1-0.4-0.90.50.8
Intermittent access intake escalation0.10.71.9-1.41.40.7-0.7-0.9-0.8-0.70.50.20.3-0.6-1.10.71.0
Intermittent access intake escalation 20.50.81.7-1.31.30.7-0.8-0.9-0.9-0.80.60.20.4-0.7-1.10.71.0
Intermitt. access day 1 inactive lever presses0.10.81.81.3-1.3-0.90.80.90.80.7-0.6-0.4-0.40.61.3-0.7-0.9
Intermitt. access day 15 inactive lever presses0.63.44.52.1-2.1-1.81.81.91.81.8-1.7-1.7-1.61.71.9-2.0-1.8
Intermitt. access escalation Index0.20.81.4-0.90.91.1-0.9-0.8-0.8-0.80.91.11.2-0.8-0.70.80.6
Intermittent access day 1 total infusions1.44.36.12.5-2.5-2.02.02.12.12.0-1.8-1.7-1.61.92.4-1.9-2.3
Intermittent access day 15 total infusions0.40.91.41.0-1.0-1.01.00.90.90.9-1.0-1.2-1.00.91.0-0.9-0.9
Intermittent access terminal intake (last 3 days)1.11.92.31.5-1.5-1.31.31.31.31.3-1.4-1.5-1.31.31.5-1.1-1.4
Intermittent access total infusions1.51.82.51.5-1.5-1.31.31.31.31.3-1.3-1.4-1.21.21.6-1.1-1.4
Intermittent access day 1 locomotion1.32.43.61.9-1.9-1.51.51.61.61.5-1.4-1.1-1.21.41.7-1.5-1.6
Intermittent access day 15 total locomotion0.00.00.20.4-0.4-0.30.10.10.10.1-0.1-0.1-0.20.00.5-0.0-0.1
Intermittent access total locomotion0.10.10.40.6-0.6-0.30.30.30.30.2-0.2-0.1-0.10.10.7-0.2-0.4
Intermittent access standard deviation0.10.50.80.8-0.8-0.80.70.70.70.7-0.7-0.9-0.80.70.6-0.8-0.5
Left kidney weight0.00.10.20.2-0.2-0.20.20.10.10.2-0.3-0.4-0.40.10.2-0.2-0.2
Right kidney weight0.00.20.3-0.60.60.5-0.5-0.5-0.6-0.50.40.30.3-0.5-0.50.20.5
Cocaine induced anxiety0.10.10.50.7-0.7-0.30.30.40.40.3-0.3-0.2-0.00.30.3-0.2-0.4
Post-drug Anxiety1.11.22.1-0.50.51.0-1.1-1.1-1.1-1.21.21.41.4-1.3-1.01.31.0
Baseline Anxiety1.32.12.7-1.01.01.5-1.5-1.5-1.5-1.61.61.51.5-1.6-1.31.61.4
Tail length0.31.82.7-0.70.71.4-1.4-1.4-1.5-1.51.41.31.3-1.7-1.01.41.5
Length with tail1.77.59.2-2.22.22.6-2.9-2.9-2.9-3.02.82.72.7-3.0-2.62.82.9
Length without tail0.52.63.5-1.81.81.4-1.6-1.7-1.6-1.61.61.51.5-1.6-1.91.61.7
Times rat made contact with spout2.93.34.82.1-2.1-2.01.91.91.91.8-1.6-1.5-1.61.62.2-1.6-1.7
Lifetime Intake1.21.42.21.5-1.5-1.21.21.21.21.1-1.0-1.1-0.91.01.5-1.0-1.2
Liver weight, left3.56.07.7-2.02.02.5-2.5-2.4-2.4-2.52.72.82.7-2.6-2.12.62.4
Liver weight, right9.115.818.8-3.63.64.0-4.1-4.0-4.0-4.04.24.34.3-4.1-3.54.03.9
Locomotor activity0.10.20.50.7-0.7-0.40.30.40.40.3-0.10.1-0.00.20.4-0.5-0.3
Locomotor testing distance0.81.92.91.7-1.7-1.31.31.41.31.3-1.2-1.0-1.11.21.5-1.4-1.4
Locomotor testing rearing0.31.01.61.2-1.2-1.00.91.01.11.0-0.8-0.6-0.61.01.1-1.2-1.1
Locomotion in novel chamber0.81.01.2-1.01.01.1-1.1-1.1-1.0-1.01.01.11.1-1.0-1.00.91.0
Locomotion in novel chamber post-restriction1.03.03.4-1.51.51.8-1.8-1.8-1.8-1.81.81.81.8-1.8-1.51.81.7
Fecal boli incidents, locomotor time 10.30.81.40.9-0.9-0.80.90.90.90.9-0.9-0.9-0.90.81.2-0.6-0.9
Change in fecal boli incidents, locomotor task3.84.04.5-2.12.12.0-2.1-2.0-2.0-2.02.02.12.1-1.9-1.82.01.8
Time >=10cm from walls, locomotor time 10.10.10.2-0.40.4-0.40.20.20.30.3-0.3-0.3-0.40.40.3-0.1-0.1
Bouts of movement, locomotor time 13.14.04.81.8-1.8-2.12.12.02.02.0-2.1-2.2-2.12.02.0-2.0-1.9
Total resting periods, locomotor time 13.43.94.91.7-1.7-2.12.12.01.92.0-2.1-2.2-2.12.01.9-2.0-1.8
Rest time, locomotor task time 10.10.10.4-0.10.10.2-0.3-0.3-0.4-0.40.30.20.2-0.5-0.40.70.5
Distance moved, locomotor task time 10.20.61.0-0.60.61.0-0.8-0.8-0.8-0.80.91.01.0-0.7-0.60.50.6
Vertical activity count, locomotor time 10.10.40.8-0.90.90.6-0.6-0.6-0.6-0.60.60.50.5-0.6-0.60.40.7
Time >=10cm from walls, locomotor time 20.00.10.4-0.60.6-0.20.0-0.00.10.1-0.0-0.0-0.10.20.1-0.00.0
Bouts of movement, locomotor time 20.00.10.3-0.50.50.1-0.3-0.4-0.3-0.30.2-0.00.0-0.2-0.50.40.5
Total resting periods, locomotor time 20.00.00.1-0.20.2-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.2-0.0-0.30.20.3
Rest time, locomotor task time 21.22.02.41.4-1.4-1.61.41.41.41.4-1.5-1.5-1.41.31.5-0.9-1.4
Distance moved, locomotor task time 21.11.51.9-1.31.31.4-1.2-1.2-1.1-1.11.31.31.3-1.1-1.30.81.1
Vertical activity count, locomotor time 20.82.03.2-1.81.81.4-1.3-1.4-1.4-1.31.31.11.1-1.2-1.61.11.6
Light reinforcement 11.77.79.42.5-2.5-2.72.92.93.02.9-2.7-2.4-2.42.93.0-3.1-2.9
Light reinforcement 21.84.04.42.0-2.0-2.12.12.12.12.0-2.0-1.9-1.92.01.9-2.0-1.9
Bone: marrow area0.41.02.11.5-1.5-1.11.00.90.80.8-0.9-1.0-1.00.70.6-0.9-0.5
Bone: maximum diameter1.32.53.21.8-1.8-1.71.61.61.61.6-1.5-1.5-1.51.51.4-1.6-1.4
Bone: maximum force0.10.30.40.6-0.6-0.50.50.50.50.5-0.5-0.4-0.40.50.4-0.5-0.5
Bone: maximum moment0.20.30.50.7-0.7-0.60.60.60.60.6-0.5-0.5-0.50.60.5-0.5-0.5
Mean time between licks in bursts0.74.05.0-1.81.82.1-2.0-2.1-2.1-2.11.91.91.8-2.0-2.22.02.1
Mean num. licks in bursts0.00.10.20.4-0.4-0.40.40.40.40.4-0.3-0.4-0.40.30.4-0.4-0.1
Cd content in liver0.10.20.50.7-0.7-0.20.30.30.30.3-0.3-0.2-0.20.30.2-0.4-0.4
Co content in liver8.510.011.83.4-3.4-3.13.13.13.13.2-3.1-3.0-2.93.13.4-3.3-3.2
Cu content in liver0.50.61.81.3-1.3-0.70.60.70.60.6-0.5-0.4-0.40.41.1-0.5-0.6
Fe content in liver0.60.81.61.1-1.1-1.00.80.90.80.8-0.7-0.7-0.70.71.3-0.6-0.7
K content in liver0.10.10.30.4-0.4-0.50.40.30.20.2-0.3-0.6-0.50.00.4-0.20.1
Mg content in liver0.70.82.31.5-1.5-0.90.80.80.60.6-0.6-0.7-0.70.31.2-0.6-0.5
Mn content in liver0.00.00.0-0.10.1-0.00.10.00.00.0-0.1-0.1-0.10.00.1-0.10.1
Na content in liver0.30.31.21.1-1.1-0.50.50.40.30.3-0.4-0.5-0.40.20.5-0.3-0.1
Rb content in liver0.20.20.60.7-0.7-0.40.40.40.30.3-0.3-0.3-0.30.10.8-0.3-0.3
Se content in liver0.30.30.5-0.40.40.5-0.6-0.5-0.5-0.60.70.70.7-0.6-0.10.60.5
Sr content in liver0.20.20.6-0.10.10.4-0.4-0.5-0.5-0.50.40.30.3-0.5-0.80.40.7
Zn content in liver0.30.30.70.2-0.20.6-0.6-0.5-0.6-0.60.70.80.8-0.7-0.10.60.4
Bone: minimum diameter0.00.10.10.4-0.40.2-0.1-0.1-0.1-0.20.30.30.3-0.3-0.30.10.3
Time in familiar zone, hab. session 10.50.51.0-0.40.40.8-0.8-0.7-0.7-0.80.91.01.0-0.8-0.40.80.6
Time in novel zone, hab. session 10.70.81.3-1.11.11.0-0.8-0.8-0.8-0.80.80.80.8-0.7-1.00.90.8
Total zone transitions, hab. session 10.10.20.40.6-0.6-0.30.40.40.40.4-0.4-0.4-0.30.50.1-0.6-0.3
Total locomotion distance, hab. session 10.00.00.10.2-0.2-0.10.20.10.20.2-0.2-0.2-0.20.3-0.3-0.3-0.0
Locomotion velocity, hab. session 10.71.01.30.9-0.9-1.01.01.01.01.1-1.1-1.1-1.11.10.5-1.1-0.9
Time in familiar zone, hab. session 20.00.00.20.5-0.50.1-0.00.10.0-0.00.10.20.2-0.10.0-0.1-0.0
Time in novel zone, hab. session 20.40.51.2-1.11.10.5-0.6-0.7-0.6-0.60.60.40.4-0.5-0.60.80.6
Total zone transitions, hab. session 20.20.20.40.6-0.6-0.40.50.40.40.4-0.4-0.4-0.40.40.0-0.6-0.2
Total locomotion distance, hab. session 20.10.10.30.3-0.3-0.40.40.40.30.4-0.4-0.5-0.50.40.1-0.5-0.2
Locomotion velocity, hab. session 20.30.40.60.5-0.5-0.70.70.60.60.7-0.7-0.8-0.80.70.4-0.7-0.5
Novel to familiar place preference ratio0.60.72.0-1.41.40.8-0.8-0.8-0.8-0.70.50.40.4-0.5-1.20.60.7
Novelty place preference1.01.32.8-1.71.71.1-1.1-1.1-1.1-1.00.80.70.7-0.8-1.50.91.0
Time in novel zone, NPP test1.31.63.0-1.71.71.2-1.2-1.3-1.2-1.11.00.90.9-0.9-1.61.01.2
Total zone transitions, NPP test1.52.33.41.8-1.8-1.41.51.51.51.5-1.4-1.4-1.41.41.2-1.7-1.3
Total locomotion distance, NPP test1.42.02.61.3-1.3-1.41.41.41.41.4-1.4-1.6-1.61.50.9-1.6-1.1
Locomotion velocity, NPP test3.04.25.12.0-2.0-2.02.12.02.02.1-2.1-2.2-2.32.11.6-2.2-1.8
Intraocular pressure2.54.04.9-1.51.52.0-2.1-2.1-2.1-2.12.11.92.0-2.1-2.12.12.2
Delta distance traveled before/after self-admin2.12.33.5-1.31.31.7-1.6-1.5-1.4-1.51.61.91.8-1.5-1.01.51.2
Delta ambulatory time before/after self-admin0.20.30.9-0.40.40.7-0.6-0.5-0.4-0.50.70.90.9-0.5-0.10.60.3
Parametrial fat weight9.422.127.4-4.64.64.8-4.8-4.6-4.6-4.75.05.25.2-4.7-4.14.64.2
Pavlov. Cond. lever latency2.22.85.3-2.32.31.7-1.6-1.7-1.6-1.51.51.41.5-1.3-1.81.41.5
Pavlov. Cond. magazine entry latency0.10.20.80.9-0.9-0.40.30.30.30.3-0.3-0.3-0.30.10.3-0.2-0.2
Pavlov. Cond. change in total contacts0.30.31.61.3-1.3-0.40.30.30.20.2-0.1-0.1-0.2-0.00.4-0.2-0.1
Pavlov. Cond. index score0.91.12.71.7-1.7-1.11.01.00.90.9-0.9-0.9-1.00.71.0-0.8-0.8
Pavlov. Cond. latency score0.81.02.51.6-1.6-1.11.01.00.90.8-0.9-0.9-1.00.71.0-0.8-0.8
Pavlov. Cond. lever contacts1.61.94.62.2-2.2-1.41.31.31.21.2-1.1-1.1-1.21.01.4-1.1-1.1
Pavlov. Cond. magazine entry number0.30.41.1-1.01.00.7-0.6-0.6-0.6-0.60.60.60.7-0.5-0.50.40.4
Pavlov. Cond. intertrial magazine entries1.62.03.11.0-1.0-1.51.41.41.51.5-1.4-1.3-1.31.51.8-1.3-1.5
Pavlov. Cond. lever-magazine prob. diff.1.82.24.52.1-2.1-1.61.41.41.41.3-1.3-1.3-1.41.21.4-1.2-1.3
Pavlov. Cond. response bias1.31.63.21.8-1.8-1.31.21.21.21.1-1.1-1.1-1.21.01.1-0.9-1.0
Pavlov. Cond. lever latency1.11.51.8-1.01.01.4-1.3-1.2-1.3-1.31.31.31.3-1.3-1.41.11.3
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.3-0.30.30.30.30.3-0.3-0.2-0.20.30.4-0.1-0.3
Pavlov. Cond. change in total contacts0.30.71.10.3-0.3-1.00.80.80.80.8-0.9-1.1-1.00.80.9-0.8-0.7
Pavlov. Cond. index score0.50.71.10.5-0.5-1.00.90.80.80.9-1.0-1.0-1.00.90.9-0.7-0.8
Pavlov. Cond. latency score0.40.71.00.5-0.5-1.00.90.80.80.9-0.9-1.0-0.90.90.9-0.7-0.8
Pavlov. Cond. lever contacts0.71.01.30.7-0.7-1.11.01.01.01.0-1.1-1.1-1.11.11.1-0.9-1.1
Pavlov. Cond. magazine entry number0.10.10.1-0.30.30.3-0.3-0.3-0.2-0.30.30.30.2-0.3-0.40.10.3
Pavlov. Cond. intertrial magazine entries1.73.74.7-2.02.02.2-2.0-2.0-2.0-1.91.81.81.7-1.8-2.01.81.8
Pavlov. Cond. lever-magazine prob. diff.0.20.40.60.2-0.2-0.70.60.60.60.6-0.7-0.8-0.70.70.6-0.5-0.6
Pavlov. Cond. response bias1.31.82.21.0-1.0-1.41.41.31.31.4-1.5-1.5-1.41.41.4-1.2-1.4
Time in closed arm before self-admin0.91.62.5-1.61.61.4-1.2-1.3-1.2-1.21.11.01.1-1.1-1.31.11.1
Time in closed arm after self-admin1.61.82.2-1.41.41.5-1.4-1.4-1.4-1.31.41.31.4-1.3-1.21.41.3
Time in open arm before self-admin0.20.30.50.7-0.7-0.70.50.50.50.5-0.5-0.5-0.60.40.4-0.4-0.3
Time in open arm after self-admin2.42.63.41.8-1.8-1.71.61.71.71.6-1.5-1.2-1.31.51.8-1.4-1.7
Bone: periosteal estimation0.81.82.81.7-1.7-1.51.41.41.31.3-1.3-1.4-1.41.31.0-1.4-1.0
Bone: periosteal perimeter0.40.70.90.9-0.9-0.90.90.90.80.8-0.8-0.8-0.80.80.6-0.9-0.7
Bone: post-yield work0.61.01.31.0-1.0-1.11.01.01.01.0-1.0-1.0-1.00.90.9-0.8-0.9
Progressive ratio test 1 active lever presses0.61.11.91.2-1.2-1.11.11.11.11.0-1.0-0.9-0.90.91.4-0.8-1.1
Progressive ratio test 1 breakpoint0.71.22.01.3-1.3-1.21.11.11.11.1-1.0-0.9-0.91.01.4-0.8-1.1
Progressive ratio test 1 inactive lever presses0.71.72.91.6-1.6-1.21.31.31.41.3-1.1-0.9-0.91.21.7-1.3-1.5
Progressive ratio test 2 active lever presses0.00.10.10.3-0.3-0.30.10.10.00.0-0.2-0.3-0.3-0.00.30.4-0.0
Progressive ratio test 2 breakpoint0.00.00.20.2-0.2-0.20.10.0-0.1-0.0-0.1-0.3-0.3-0.10.20.40.1
Progressive ratio test 2 inactive lever presses0.10.20.40.6-0.6-0.50.40.40.40.4-0.4-0.5-0.50.30.6-0.2-0.5
Incentive Sensitization - Responses0.00.10.2-0.30.3-0.10.1-0.1-0.10.0-0.2-0.5-0.50.1-0.20.30.1
Incentive Sensitization - Breakpoint0.00.10.2-0.40.40.1-0.1-0.2-0.3-0.1-0.1-0.3-0.3-0.1-0.30.40.3
Sum of active levers in priming session hrs 5-61.41.31.71.3-1.3-1.21.11.11.11.1-1.1-1.2-1.31.00.9-1.1-1.0
Progressive ratio0.61.71.8-1.31.31.2-1.3-1.3-1.2-1.31.31.21.3-1.2-1.31.31.3
Food seeking constrained by brief footshock1.72.23.11.4-1.4-1.41.51.51.51.5-1.5-1.5-1.31.51.7-1.3-1.6
Seeking ratio, punishment vs. effort0.92.12.61.4-1.4-1.41.41.41.41.4-1.5-1.4-1.41.41.6-1.4-1.5
Retroperitoneal fat weight20.290.397.2-9.29.29.8-9.6-9.5-9.5-9.69.79.99.9-9.5-8.99.59.1
Reaction time number correct0.30.91.80.4-0.4-1.00.90.90.81.0-1.1-1.3-1.41.00.8-1.0-0.8
Reaction time mean minus median0.00.10.30.5-0.5-0.10.20.20.20.3-0.10.00.00.30.5-0.2-0.4
Reaction time mean minus median AUC0.00.00.00.0-0.00.1-0.00.00.00.00.10.20.10.10.1-0.1-0.1
Reaction time num false alarms0.20.40.70.4-0.4-0.60.70.70.70.6-0.7-0.6-0.60.60.9-0.7-0.8
Reaction time num false alarms AUC0.30.81.10.6-0.6-0.80.90.90.90.9-0.9-0.9-0.90.81.1-0.9-1.0
Reaction time trials correct on left0.30.91.80.4-0.4-1.00.90.90.81.0-1.1-1.3-1.41.00.8-1.0-0.8
Reaction time trials on left0.31.01.90.4-0.4-1.01.00.90.91.0-1.1-1.3-1.41.10.9-1.0-0.8
Reaction time mean0.30.71.4-0.20.20.9-0.9-0.7-0.8-0.80.91.21.2-1.0-0.31.10.5
Reaction time mean AUC0.20.51.2-0.10.10.8-0.7-0.6-0.7-0.70.81.11.0-0.8-0.20.90.3
Median of all reaction times0.50.81.7-0.20.21.0-0.9-0.8-0.9-0.91.01.31.2-1.1-0.31.20.5
Reaction time omissions0.10.10.20.2-0.2-0.20.30.30.40.3-0.2-0.0-0.00.30.4-0.3-0.4
Reaction time false alarm rate0.10.10.20.3-0.3-0.20.30.30.30.2-0.2-0.1-0.10.10.4-0.2-0.4
Reaction time premature initiation rate0.10.20.3-0.30.30.4-0.4-0.4-0.4-0.40.40.40.5-0.5-0.40.50.4
Reaction time premature initiations0.00.00.1-0.10.1-0.20.10.10.10.1-0.2-0.3-0.30.10.0-0.1-0.0
Std. dev. reaction times0.10.20.5-0.20.20.6-0.5-0.4-0.5-0.50.60.70.7-0.5-0.20.50.3
Reaction time trials completed0.31.01.90.4-0.4-1.01.00.90.91.0-1.1-1.3-1.41.10.9-1.0-0.8
Reaction time trials AUC0.41.22.40.6-0.6-1.21.11.01.01.1-1.3-1.5-1.51.21.0-1.1-0.9
Run reversals in cocaine runway, females0.10.10.3-0.50.50.1-0.0-0.1-0.1-0.0-0.2-0.3-0.30.1-0.00.00.1
Run reversals in cocaine runway, males0.50.51.00.4-0.4-0.60.70.60.60.7-0.8-1.0-0.90.80.5-0.8-0.6
Latency to leave start box in cocaine runway0.20.30.50.7-0.7-0.50.60.60.60.6-0.5-0.4-0.50.60.6-0.6-0.6
Latency to leave start box in cocaine runway, F0.30.40.70.8-0.8-0.60.60.60.60.6-0.6-0.6-0.60.60.5-0.6-0.5
Latency to leave start box in cocaine runway, M0.10.10.2-0.30.30.3-0.3-0.3-0.3-0.30.30.50.5-0.2-0.00.20.1
Std. dev. time between licks in bursts0.00.10.20.3-0.30.2-0.2-0.2-0.2-0.20.20.50.4-0.2-0.00.3-0.1
Total sessions with >9 infusions0.10.10.50.7-0.7-0.20.20.30.30.20.00.30.30.10.6-0.1-0.3
Short access day 1 total inactive lever presses3.36.57.82.8-2.8-2.62.52.62.62.5-2.4-2.2-2.22.52.8-2.5-2.6
Short access day 10 total inactive lever presses0.42.53.41.3-1.3-1.71.61.61.71.6-1.5-1.5-1.41.71.7-1.9-1.7
Short access day 1 total infusions0.61.22.31.5-1.5-1.01.01.11.21.0-0.7-0.4-0.40.91.5-1.0-1.2
Short access day 10 total infusions1.32.23.51.9-1.9-1.51.41.51.51.4-1.3-1.3-1.21.31.7-1.1-1.5
Short access total infusions0.20.20.80.9-0.9-0.40.30.40.40.3-0.1-0.00.10.20.7-0.2-0.4
Short access day 1 locomotion1.01.72.91.7-1.7-1.31.21.31.31.2-1.1-0.9-0.91.11.5-1.1-1.3
Short access day 10 total locomotion0.72.74.42.1-2.1-1.51.61.61.61.6-1.5-1.4-1.41.41.8-1.5-1.6
Short access total locomotion0.00.10.30.6-0.6-0.10.10.10.10.10.10.30.2-0.00.4-0.0-0.1
One hour access (0.3 mA shock)0.30.40.80.9-0.9-0.80.60.60.50.5-0.5-0.5-0.50.40.8-0.1-0.5
Compulsive drug intake0.40.61.1-1.11.10.5-0.7-0.7-0.6-0.60.81.01.0-0.5-0.70.70.7
One hour access (shock baseline)0.61.62.41.5-1.5-1.31.21.21.11.1-1.3-1.4-1.31.01.4-0.9-1.2
Social response proportion0.50.61.1-0.90.90.7-0.8-0.7-0.7-0.70.91.11.1-0.7-0.50.60.5
Social responses0.10.10.3-0.50.50.3-0.2-0.2-0.2-0.20.30.50.5-0.20.20.1-0.1
Social time0.61.01.6-1.01.01.0-1.0-0.9-0.9-1.01.11.31.2-1.0-0.70.90.7
Soleus weight5.917.519.13.8-3.8-4.24.34.44.44.4-4.3-4.2-4.24.33.9-4.2-4.2
Bone: stiffness0.00.00.00.0-0.0-0.10.10.10.10.1-0.1-0.1-0.10.00.1-0.0-0.1
Tibialis anterior weight4.515.517.63.6-3.6-3.84.14.14.14.1-4.1-3.9-3.94.13.6-4.1-4.2
Time to tail flick, vehicle, before self-admin0.70.91.4-1.01.01.2-1.0-1.0-1.0-1.00.80.60.7-0.9-1.10.90.9
Time to tail flick, vehicle, after self-admin1.32.73.3-1.21.21.8-1.7-1.7-1.8-1.71.61.51.6-1.7-1.71.61.8
Time to tail flick, test, before self-admin0.10.10.20.1-0.1-0.30.30.30.30.3-0.2-0.1-0.10.30.4-0.2-0.3
Time to tail flick, test, after self-admin0.10.10.20.2-0.2-0.40.40.30.30.3-0.4-0.5-0.50.30.2-0.2-0.3
Delta time to tail flick, vehicle, before/after SA0.00.00.20.2-0.20.1-0.1-0.2-0.2-0.20.20.10.1-0.2-0.30.00.4
Delta time to tail flick, test, before/after SA1.11.42.11.0-1.0-1.21.21.11.11.1-1.3-1.4-1.51.10.9-1.1-1.0
Tibia length2.87.79.3-1.91.92.8-2.9-2.8-2.9-2.93.03.03.0-3.1-2.52.82.8
Ambulatory time before self-admin0.00.10.3-0.00.0-0.50.30.20.20.2-0.3-0.4-0.50.2-0.1-0.1-0.0
Ambulatory time after self-admin0.50.91.4-1.01.00.9-0.9-0.9-0.9-0.91.01.21.1-0.9-0.61.00.7
Bone: tissue strength0.40.40.5-0.70.70.6-0.6-0.6-0.5-0.60.60.70.7-0.6-0.40.60.5
Total heroin consumption3.33.94.41.9-1.9-2.12.12.12.02.1-2.0-1.9-2.02.01.8-1.9-2.0
Bone: trabecular number3.77.08.62.9-2.9-2.72.62.72.72.6-2.5-2.2-2.22.62.8-2.5-2.8
Bone: trabecular spacing1.62.32.8-1.31.31.7-1.6-1.5-1.6-1.61.61.51.5-1.6-1.61.41.6
Bone: trabecular thickness0.60.91.21.1-1.1-0.90.90.91.00.9-0.9-0.7-0.70.90.9-0.9-1.0
Bone: trabecular tissue density0.10.30.40.4-0.4-0.60.50.50.40.4-0.6-0.6-0.60.40.6-0.3-0.6
Water consumed over 24 hours0.30.60.80.8-0.8-0.90.80.80.80.7-0.7-0.8-0.80.70.8-0.6-0.6
Number of responses in last shaping day0.20.20.50.1-0.10.2-0.4-0.4-0.5-0.50.50.40.4-0.6-0.60.50.7