Hub : Genes

Clip4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative polyA NM_001013942.1 0.04 0.04 3.5e-03 0.01 0.01 0.01 0.01 1.5e-02 4.5e-02 1.9e-02 2.8e-02
2 Brain alternative polyA XM_063261626.1 0.04 0.04 4.3e-03 0.01 0.01 0.01 0.01 1.8e-02 6.1e-02 2.5e-02 3.7e-02
3 BLA gene expression Clip4 0.19 0.1 6.9e-12 0.17 0.2 0.19 0.18 3.4e-09 7.8e-11 3.7e-10 9.3e-10
4 NAcc gene expression Clip4 0.03 0.02 3.8e-05 0.03 0.03 0.03 0.03 8.5e-05 3.0e-05 4.2e-05 6.2e-05
5 pVTA gene expression Clip4 0.26 0.2 1.1e-16 0.21 0.22 0.22 0.21 7.8e-17 2.2e-17 3.2e-17 4.1e-17
6 LHb gene expression Clip4 0.22 0.16 5.0e-04 0.12 0.12 0.12 0.11 1.1e-03 7.2e-04 1.2e-03 1.2e-03
7 Adipose gene expression Clip4 0.41 0.16 0.0e+00 0.41 0.41 0.41 0.41 4.2e-48 7.3e-49 1.6e-49 4.4e-49
8 IL gene expression Clip4 0.17 0.14 7.0e-03 0.05 0.02 0.04 0.03 2.7e-02 1.3e-01 4.9e-02 7.9e-02
9 RMTg gene expression Clip4 0.11 0.1 5.8e-03 0.07 0.08 0.08 0.08 6.2e-03 4.2e-03 3.9e-03 3.8e-03
10 PL gene expression Clip4 0.11 0.07 5.5e-14 0.13 0.13 0.13 0.13 3.8e-14 5.0e-14 1.1e-13 4.7e-14
11 OFC gene expression Clip4 0.19 0.19 4.3e-03 0.07 0.08 0.07 0.08 9.6e-03 5.6e-03 8.8e-03 5.7e-03
12 Adipose mRNA stability Clip4 0.08 0.06 1.6e-06 0.06 0.05 0.06 0.06 2.1e-07 4.5e-06 2.9e-07 4.3e-07
13 IC gene expression Clip4 0.24 0.16 1.3e-09 0.25 0.23 0.24 0.24 8.8e-11 3.3e-10 1.4e-10 1.3e-10
14 Brain gene expression Clip4 0.29 0.13 0.0e+00 0.32 0.32 0.33 0.32 4.9e-31 1.4e-30 3.0e-31 1.1e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density5.18.810.1-3.23.23.03.03.03.02.82.63.12.62.9-3.12.93.0
Area under the delay curve2.02.33.2-1.71.71.51.51.41.41.41.41.81.41.3-1.71.51.6
BMI with tail0.20.72.31.5-1.5-0.7-0.7-0.7-0.6-0.6-0.6-0.9-0.6-0.50.8-0.7-0.6
BMI without tail0.31.01.31.1-1.1-1.0-1.0-1.1-1.0-1.0-1.0-0.8-1.1-1.00.7-1.0-0.8
Body weight1.56.67.02.5-2.5-2.6-2.6-2.6-2.6-2.6-2.6-2.5-2.6-2.62.4-2.6-2.5
Weight adjusted by age0.10.10.10.2-0.2-0.3-0.3-0.3-0.3-0.3-0.2-0.1-0.4-0.30.2-0.2-0.2
Bone surface2.13.95.2-2.32.32.01.91.91.91.81.92.21.91.8-1.82.01.8
Bone volume2.64.66.0-2.42.42.22.22.22.12.01.92.41.92.0-2.12.12.1
Breakpoint value in progressive ratio session0.70.81.5-1.21.20.90.90.90.80.80.71.00.70.8-0.80.80.9
Number of licking bursts0.20.40.8-0.80.80.50.60.60.50.50.30.90.30.4-0.80.40.7
Context. condit. distance diff. score0.10.20.80.9-0.9-0.3-0.3-0.3-0.3-0.2-0.0-0.5-0.1-0.20.30.0-0.5
Locomotion velocity, session 10.10.10.20.1-0.1-0.3-0.2-0.2-0.2-0.4-0.4-0.1-0.4-0.30.3-0.1-0.3
Locomotion distance, session 12.02.63.0-1.71.71.71.71.71.71.51.61.51.61.7-1.31.71.4
Locomotion velocity, session 20.10.10.30.1-0.1-0.4-0.4-0.4-0.4-0.4-0.4-0.2-0.3-0.50.5-0.4-0.5
Locomotion distance, session 20.10.10.4-0.70.70.10.10.10.0-0.1-0.20.3-0.1-0.00.10.10.1
Locomotion velocity, session 30.50.50.9-1.01.00.70.70.70.60.70.70.70.70.6-0.70.70.7
Locomotion distance, session 31.11.22.0-1.41.41.11.11.11.01.00.81.10.80.9-1.11.21.2
Stereotopy head waving bouts, day 31.01.21.4-1.21.21.11.11.11.11.11.21.11.21.0-1.00.81.0
Stereotopy head waving duration, day 30.00.00.1-0.20.20.10.10.10.00.10.10.10.20.0-0.0-0.2-0.0
Locomotion velocity, session 70.80.91.8-1.31.30.90.90.90.90.90.90.90.90.8-0.91.00.9
Locomotion distance, session 70.00.00.1-0.10.1-0.2-0.2-0.2-0.3-0.2-0.2-0.2-0.2-0.30.2-0.3-0.2
Stereotopy head waving bouts, day 70.10.10.3-0.50.50.20.30.30.20.20.10.30.10.2-0.20.30.4
Stereotopy head waving duration, day 70.60.71.2-1.11.10.80.90.80.80.70.60.90.60.7-0.90.81.0
Locomotion velocity, session 80.00.00.1-0.30.3-0.00.0-0.0-0.1-0.1-0.20.1-0.2-0.2-0.2-0.20.0
Locomotion distance, session 80.10.20.5-0.20.20.40.40.30.40.50.60.20.60.4-0.10.70.2
Degree of sensitization distance1.51.62.01.4-1.4-1.2-1.3-1.2-1.2-1.2-1.0-1.2-1.0-1.11.3-1.4-1.3
Degree of sensitization stereotypy0.00.00.1-0.30.3-0.1-0.0-0.0-0.1-0.1-0.2-0.0-0.2-0.10.10.10.1
Conditioned locomotion2.22.53.4-1.21.21.71.61.61.71.81.81.31.81.7-1.31.71.4
Cocaine response after cond. corrected2.32.84.0-1.71.71.61.71.61.61.51.52.01.61.6-2.01.61.7
Cocaine response after cond. not corrected3.23.84.4-1.81.81.91.91.92.01.92.01.92.02.0-1.92.11.9
Cocaine response before conditioning0.50.71.2-0.60.60.90.80.80.91.01.00.31.01.0-0.21.10.7
Saline control response1.01.32.4-1.61.61.11.21.11.10.80.61.40.60.9-1.21.01.1
Bone: connectivity density5.07.89.3-3.03.02.82.82.82.82.62.53.02.42.7-2.92.72.8
Bone: cortical apparent density0.91.21.7-1.01.01.11.11.11.11.11.01.11.01.1-1.31.01.2
Bone: cortical area0.71.11.6-1.01.01.11.11.11.11.01.01.01.01.1-0.81.20.9
Bone: cortical porosity0.80.91.3-0.70.71.00.91.01.01.00.90.81.01.0-1.10.91.1
Bone: cortical porosity1.11.11.8-0.90.91.11.11.11.11.10.91.11.01.1-1.31.01.2
Bone: cortical thickness0.00.00.20.3-0.30.20.20.20.30.10.10.10.10.4-0.10.40.1
Bone: cortical thickness1.31.52.4-0.70.71.31.21.21.31.31.51.11.51.5-1.11.51.1
Bone: cortical tissue density0.60.91.3-0.80.80.90.90.90.90.90.91.00.90.9-1.20.81.0
Condit. Reinf. active minus inactive responses0.20.20.5-0.30.3-0.5-0.5-0.5-0.5-0.5-0.6-0.1-0.5-0.60.4-0.7-0.5
Condit. Reinf. active-inactive response ratio0.20.20.3-0.40.4-0.4-0.3-0.4-0.4-0.4-0.5-0.0-0.5-0.60.3-0.6-0.4
Condit. Reinf. active responses0.70.81.9-1.41.40.80.80.80.80.70.61.10.70.7-0.90.70.8
Condit. Reinf. inactive responses1.62.02.3-1.31.31.41.41.51.51.31.31.51.31.5-1.51.41.4
Incentive salience index mean0.50.62.5-1.61.60.50.60.50.50.40.30.90.40.3-0.80.30.5
Condit. Reinf. lever presses1.82.56.1-2.52.51.41.51.41.31.31.11.81.11.1-1.71.21.5
Condit. Reinf. active minus inactive responses2.73.54.8-1.21.21.91.81.92.02.12.21.72.12.1-1.82.01.9
Condit. Reinf. active-inactive response ratio0.50.61.1-0.60.60.80.70.70.80.91.10.51.00.8-0.60.90.7
Condit. Reinf. active responses2.13.04.4-0.90.91.81.71.71.92.02.11.42.02.0-1.61.81.7
Condit. Reinf. inactive responses1.31.72.5-0.50.51.41.31.41.41.51.61.11.61.6-1.21.41.3
Condit. Reinf. lever presses1.42.03.0-0.60.61.51.41.41.51.61.71.31.61.6-1.41.41.5
Condit. Reinf. lever reinforcers received1.92.63.7-0.80.81.71.61.61.71.91.91.51.91.9-1.51.71.7
Conditioned reinforcement - actives0.20.30.7-0.70.70.50.40.40.40.50.60.60.50.4-0.80.30.4
Conditioned reinforcement - inactives2.03.04.1-1.81.81.71.71.71.61.71.71.81.61.6-2.01.71.8
Conditioned locomotion0.20.30.7-0.10.1-0.6-0.6-0.7-0.7-0.6-0.6-0.1-0.6-0.80.1-0.7-0.5
Patch foraging indifference point 0 sec0.20.30.70.1-0.1-0.6-0.5-0.6-0.6-0.7-0.8-0.3-0.8-0.80.5-0.6-0.5
Patch foraging indifference point AUC1.01.42.8-1.11.11.11.21.31.21.00.81.40.71.1-1.71.21.5
Delay disc. indifference point, 0s delay0.70.71.71.3-1.3-0.8-0.8-0.8-0.7-0.7-0.7-0.9-0.7-0.60.9-0.7-0.7
Delay disc. indifference point, 16s delay1.61.72.4-1.61.61.31.31.31.21.11.01.51.01.1-1.51.31.4
Delay disc. indifference point, 2s delay0.00.00.0-0.10.1-0.0-0.0-0.0-0.0-0.0-0.00.10.1-0.1-0.00.10.1
Delay disc. indifference point, 24s delay5.35.96.8-2.52.52.42.42.32.42.42.62.62.62.3-2.32.42.4
Delay disc. indifference point, 4s delay0.20.20.5-0.60.60.40.40.40.40.30.30.60.30.3-0.70.40.6
Delay disc. indifference point, 8s delay1.51.82.6-1.61.61.21.31.21.21.11.21.61.21.1-1.41.41.3
Indifference point function ln k0.10.10.40.5-0.5-0.1-0.2-0.2-0.10.00.3-0.50.3-0.00.6-0.0-0.4
Indifference point function log k0.10.10.40.5-0.5-0.1-0.2-0.2-0.10.00.3-0.50.3-0.00.6-0.0-0.4
Patch foraging total patch changes 0 sec0.20.30.60.1-0.1-0.5-0.5-0.5-0.6-0.6-0.8-0.3-0.7-0.70.5-0.5-0.4
Patch foraging total patch changes 12 sec0.91.12.00.8-0.8-1.1-1.0-1.0-1.1-1.2-1.4-0.9-1.4-1.10.9-1.0-0.9
Patch foraging total patch changes 18 sec0.10.10.5-0.20.2-0.3-0.1-0.2-0.3-0.3-0.60.1-0.7-0.4-0.3-0.30.2
Patch foraging total patch changes 24 sec1.32.22.91.2-1.2-1.5-1.5-1.5-1.6-1.6-1.7-1.4-1.7-1.71.2-1.6-1.3
Patch foraging total patch changes 6 sec0.00.10.2-0.10.1-0.2-0.1-0.1-0.2-0.3-0.50.1-0.4-0.30.0-0.10.0
Patch foraging time to switch 0 sec0.10.20.3-0.60.60.40.40.40.40.40.40.20.40.4-0.20.40.4
Patch foraging water rate 0 sec0.10.10.20.5-0.5-0.3-0.3-0.3-0.3-0.4-0.4-0.2-0.3-0.40.1-0.4-0.2
Patch foraging water rate 12 sec1.53.15.62.4-2.4-1.7-1.8-1.8-1.7-1.4-1.2-2.1-1.2-1.52.0-1.4-1.8
Patch foraging water rate 18 sec0.61.02.41.5-1.5-0.8-0.9-0.9-0.8-0.7-0.5-1.1-0.5-0.71.2-0.8-1.2
Patch foraging water rate 24 sec2.63.66.72.6-2.6-1.8-1.8-1.8-1.7-1.8-1.8-1.9-1.7-1.61.7-1.7-1.6
Patch foraging water rate 6 sec1.52.23.21.8-1.8-1.5-1.5-1.5-1.5-1.3-1.1-1.6-1.2-1.41.6-1.4-1.4
Seeking ratio, delayed vs. immediate footshock0.50.60.80.7-0.7-0.7-0.7-0.7-0.7-0.8-0.9-0.7-0.8-0.70.8-0.5-0.8
Distance traveled before self-admin0.00.00.10.2-0.20.10.00.00.00.10.20.20.30.10.2-0.0-0.2
Distance traveled after self-admin1.11.32.21.1-1.1-1.2-1.1-1.1-1.2-1.3-1.5-0.8-1.4-1.20.8-1.3-1.0
Extensor digitorum longus weight4.818.920.7-3.93.94.54.54.54.54.44.24.34.34.5-4.24.44.5
Bone: elastic displacement0.60.71.2-0.50.50.80.80.91.00.91.00.51.01.1-0.91.00.8
Bone: elastic work1.01.31.7-1.31.31.11.11.11.21.11.20.81.21.3-1.01.31.0
Bone: endosteal estimation0.40.92.1-1.41.40.90.90.80.80.91.00.81.00.7-0.50.80.5
Bone: endosteal perimeter0.20.51.5-1.21.20.60.60.60.50.50.60.70.60.4-0.40.60.4
Epididymis fat weight15.653.556.37.0-7.0-7.5-7.5-7.5-7.5-7.4-7.3-7.2-7.3-7.47.2-7.2-7.4
Delta time in closed arm before/after self-admin0.00.00.0-0.10.1-0.0-0.0-0.0-0.0-0.00.1-0.1-0.00.0-0.10.1-0.0
Delta time in open arm before/after self-admin0.70.71.3-0.70.70.70.90.90.80.70.41.10.40.8-1.10.71.1
Diff in mean of infusions in LGA sessions0.10.10.2-0.30.30.00.10.10.1-0.0-0.20.4-0.2-0.0-0.4-0.10.4
Delay discount exponential model param3.03.44.52.0-2.0-1.8-1.8-1.7-1.7-1.7-1.7-2.1-1.7-1.62.0-1.8-1.9
Extinction: sum of active levers before priming1.11.21.5-1.21.21.11.11.11.11.11.21.21.11.0-1.01.11.1
Active lever presses in extinction session 60.00.00.1-0.00.0-0.1-0.00.0-0.0-0.2-0.20.0-0.2-0.00.40.0-0.1
Bone: final force0.20.30.6-0.80.80.50.50.50.50.40.40.50.40.4-0.50.40.5
Bone: final moment0.20.30.7-0.80.80.50.50.50.50.50.40.50.50.4-0.50.50.4
Food consumed during 24 hour testing period0.10.10.20.2-0.20.40.30.40.40.30.30.30.40.5-0.10.50.3
Glucose0.50.71.30.6-0.6-0.9-0.8-0.8-0.9-0.9-1.0-0.6-1.1-1.00.5-1.1-0.7
Heart weight2.84.45.61.9-1.9-2.1-2.2-2.2-2.2-2.1-2.0-2.4-2.0-2.12.0-2.0-2.2
Delay discount hyperbolic model param2.12.43.31.7-1.7-1.5-1.5-1.4-1.4-1.4-1.4-1.8-1.4-1.31.7-1.5-1.6
Intermittent access intake day 1-15 change0.30.51.51.2-1.2-0.6-0.7-0.7-0.6-0.40.0-0.9-0.1-0.40.9-0.5-0.8
Intermittent access intake escalation0.40.81.91.4-1.4-0.7-0.9-0.8-0.7-0.5-0.2-1.1-0.3-0.61.1-0.7-1.0
Intermittent access intake escalation 20.70.81.71.3-1.3-0.8-0.9-0.9-0.8-0.6-0.2-1.1-0.4-0.71.1-0.7-1.0
Intermitt. access day 1 inactive lever presses0.20.81.9-1.31.30.80.90.80.70.60.41.40.40.6-1.30.70.9
Intermitt. access day 15 inactive lever presses1.73.54.5-2.12.11.81.91.81.81.71.72.01.61.7-1.92.01.8
Intermitt. access escalation Index0.50.71.40.9-0.9-0.9-0.8-0.8-0.8-0.9-1.1-0.7-1.2-0.80.7-0.8-0.6
Intermittent access day 1 total infusions2.74.46.1-2.52.52.02.12.12.01.81.72.41.61.9-2.41.92.3
Intermittent access day 15 total infusions0.60.91.4-1.01.01.00.90.90.91.01.21.01.00.9-1.00.90.9
Intermittent access terminal intake (last 3 days)1.41.92.3-1.51.51.31.31.31.31.41.51.51.31.3-1.51.11.4
Intermittent access total infusions1.51.82.5-1.51.51.31.31.31.31.31.41.51.21.2-1.61.11.4
Intermittent access day 1 locomotion1.92.53.6-1.91.91.51.61.61.51.41.11.71.21.4-1.71.51.6
Intermittent access day 15 total locomotion0.00.10.2-0.40.40.10.10.10.10.10.10.40.20.0-0.50.00.1
Intermittent access total locomotion0.10.10.4-0.60.60.30.30.30.20.20.10.60.10.1-0.70.20.4
Intermittent access standard deviation0.30.50.8-0.80.80.70.70.70.70.70.90.70.80.7-0.60.80.5
Left kidney weight0.00.10.2-0.20.20.20.10.10.20.30.40.30.40.1-0.20.20.2
Right kidney weight0.00.20.30.6-0.6-0.5-0.5-0.6-0.5-0.4-0.3-0.3-0.3-0.50.5-0.2-0.5
Cocaine induced anxiety0.10.20.5-0.70.70.30.40.40.30.30.20.40.00.3-0.30.20.4
Post-drug Anxiety1.11.22.10.5-0.5-1.1-1.1-1.1-1.2-1.2-1.4-0.9-1.4-1.31.0-1.3-1.0
Baseline Anxiety1.82.02.71.0-1.0-1.5-1.5-1.5-1.6-1.6-1.5-1.1-1.5-1.61.3-1.6-1.4
Tail length0.41.72.70.7-0.7-1.4-1.4-1.5-1.5-1.4-1.3-1.1-1.3-1.71.0-1.4-1.5
Length with tail1.77.49.22.2-2.2-2.9-2.9-2.9-3.0-2.8-2.7-2.5-2.7-3.02.6-2.8-2.9
Length without tail0.82.73.51.8-1.8-1.6-1.7-1.6-1.6-1.6-1.5-1.7-1.5-1.61.9-1.6-1.7
Times rat made contact with spout2.93.34.8-2.12.11.91.91.91.81.61.52.21.61.6-2.21.61.7
Lifetime Intake1.21.52.2-1.51.51.21.21.21.11.01.11.40.91.0-1.51.01.2
Liver weight, left3.65.97.72.0-2.0-2.5-2.4-2.4-2.5-2.7-2.8-2.1-2.7-2.62.1-2.6-2.4
Liver weight, right8.915.518.83.6-3.6-4.1-4.0-4.0-4.0-4.2-4.3-3.5-4.3-4.13.5-4.0-3.9
Locomotor activity0.10.20.5-0.70.70.30.40.40.30.1-0.10.70.00.2-0.40.50.3
Locomotor testing distance1.11.92.9-1.71.71.31.41.31.31.21.01.61.11.2-1.51.41.4
Locomotor testing rearing0.51.11.6-1.21.20.91.01.11.00.80.61.10.61.0-1.11.21.1
Locomotion in novel chamber0.81.11.51.0-1.0-1.1-1.1-1.0-1.0-1.0-1.1-1.2-1.1-1.01.0-0.9-1.0
Locomotion in novel chamber post-restriction1.83.03.41.5-1.5-1.8-1.8-1.8-1.8-1.8-1.8-1.6-1.8-1.81.5-1.8-1.7
Fecal boli incidents, locomotor time 10.60.81.4-0.90.90.90.90.90.90.90.90.80.90.8-1.20.60.9
Change in fecal boli incidents, locomotor task4.04.04.52.1-2.1-2.1-2.0-2.0-2.0-2.0-2.1-1.8-2.1-1.91.8-2.0-1.8
Time >=10cm from walls, locomotor time 10.10.10.20.4-0.40.20.20.30.30.30.30.50.40.4-0.30.10.1
Bouts of movement, locomotor time 13.54.04.8-1.81.82.12.02.02.02.12.21.82.12.0-2.02.01.9
Total resting periods, locomotor time 13.43.84.9-1.71.72.12.01.92.02.12.21.72.12.0-1.92.01.8
Rest time, locomotor task time 10.10.10.40.1-0.1-0.3-0.3-0.4-0.4-0.3-0.2-0.2-0.2-0.50.4-0.7-0.5
Distance moved, locomotor task time 10.40.61.00.6-0.6-0.8-0.8-0.8-0.8-0.9-1.0-0.8-1.0-0.70.6-0.5-0.6
Vertical activity count, locomotor time 10.20.40.80.9-0.9-0.6-0.6-0.6-0.6-0.6-0.5-0.7-0.5-0.60.6-0.4-0.7
Time >=10cm from walls, locomotor time 20.00.10.40.6-0.60.0-0.00.10.10.00.00.40.10.2-0.10.0-0.0
Bouts of movement, locomotor time 20.10.10.30.5-0.5-0.3-0.4-0.3-0.3-0.20.0-0.3-0.0-0.20.5-0.4-0.5
Total resting periods, locomotor time 20.00.00.10.2-0.2-0.1-0.1-0.1-0.10.10.2-0.00.2-0.00.3-0.2-0.3
Rest time, locomotor task time 21.62.02.4-1.41.41.41.41.41.41.51.51.61.41.3-1.50.91.4
Distance moved, locomotor task time 21.21.51.81.3-1.3-1.2-1.2-1.1-1.1-1.3-1.3-1.2-1.3-1.11.3-0.8-1.1
Vertical activity count, locomotor time 21.52.03.21.8-1.8-1.3-1.4-1.4-1.3-1.3-1.1-1.7-1.1-1.21.6-1.1-1.6
Light reinforcement 13.17.79.4-2.52.52.92.93.02.92.72.42.62.42.9-3.03.12.9
Light reinforcement 22.64.04.3-2.02.02.12.12.12.02.01.92.01.92.0-1.92.01.9
Bone: marrow area0.40.92.1-1.51.51.00.90.80.80.91.00.81.00.7-0.60.90.5
Bone: maximum diameter1.42.53.2-1.81.81.61.61.61.61.51.51.81.51.5-1.41.61.4
Bone: maximum force0.10.30.4-0.60.60.50.50.50.50.50.40.40.40.5-0.40.50.5
Bone: maximum moment0.20.30.5-0.70.70.60.60.60.60.50.50.50.50.6-0.50.50.5
Mean time between licks in bursts1.64.05.11.8-1.8-2.0-2.1-2.1-2.1-1.9-1.9-2.3-1.8-2.02.2-2.0-2.1
Mean num. licks in bursts0.10.10.2-0.40.40.40.40.40.40.30.40.30.40.3-0.40.40.1
Cd content in liver0.10.20.5-0.70.70.30.30.30.30.30.20.20.20.3-0.20.40.4
Co content in liver8.710.111.8-3.43.43.13.13.13.23.13.03.12.93.1-3.43.33.2
Cu content in liver0.60.71.8-1.31.30.60.70.60.60.50.41.20.40.4-1.10.50.6
Fe content in liver0.70.82.1-1.11.10.80.90.80.80.70.71.40.70.7-1.30.60.7
K content in liver0.10.10.3-0.40.40.40.30.20.20.30.60.30.50.0-0.40.2-0.1
Mg content in liver0.80.82.3-1.51.50.80.80.60.60.60.71.10.70.3-1.20.60.5
Mn content in liver0.00.00.00.1-0.10.10.00.00.00.10.1-0.20.10.0-0.10.1-0.1
Na content in liver0.30.31.2-1.11.10.50.40.30.30.40.50.50.40.2-0.50.30.1
Rb content in liver0.20.20.6-0.70.70.40.40.30.30.30.30.70.30.1-0.80.30.3
Se content in liver0.20.30.50.4-0.4-0.6-0.5-0.5-0.6-0.7-0.7-0.3-0.7-0.60.1-0.6-0.5
Sr content in liver0.30.20.60.1-0.1-0.4-0.5-0.5-0.5-0.4-0.3-0.7-0.3-0.50.8-0.4-0.7
Zn content in liver0.30.30.7-0.20.2-0.6-0.5-0.6-0.6-0.7-0.8-0.1-0.8-0.70.1-0.6-0.4
Bone: minimum diameter0.00.10.1-0.40.4-0.1-0.1-0.1-0.2-0.3-0.3-0.0-0.3-0.30.3-0.1-0.3
Time in familiar zone, hab. session 10.60.51.00.4-0.4-0.8-0.7-0.7-0.8-0.9-1.0-0.6-1.0-0.80.4-0.8-0.6
Time in novel zone, hab. session 10.80.81.31.1-1.1-0.8-0.8-0.8-0.8-0.8-0.8-1.0-0.8-0.71.0-0.9-0.8
Total zone transitions, hab. session 10.10.20.4-0.60.60.40.40.40.40.40.40.20.30.5-0.10.60.3
Total locomotion distance, hab. session 10.00.00.1-0.20.20.20.10.20.20.20.2-0.20.20.30.30.30.0
Locomotion velocity, hab. session 10.71.01.3-0.90.91.01.01.01.11.11.10.71.11.1-0.51.10.9
Time in familiar zone, hab. session 20.00.00.2-0.50.5-0.00.10.0-0.0-0.1-0.20.3-0.2-0.1-0.00.10.0
Time in novel zone, hab. session 20.50.51.21.1-1.1-0.6-0.7-0.6-0.6-0.6-0.4-0.8-0.4-0.50.6-0.8-0.6
Total zone transitions, hab. session 20.20.20.4-0.60.60.50.40.40.40.40.40.30.40.4-0.00.60.2
Total locomotion distance, hab. session 20.10.10.3-0.30.30.40.40.30.40.40.50.20.50.4-0.10.50.2
Locomotion velocity, hab. session 20.30.40.6-0.50.50.70.60.60.70.70.80.50.80.7-0.40.70.5
Novel to familiar place preference ratio0.70.82.01.4-1.4-0.8-0.8-0.8-0.7-0.5-0.4-1.0-0.4-0.51.2-0.6-0.7
Novelty place preference1.21.32.81.7-1.7-1.1-1.1-1.1-1.0-0.8-0.7-1.2-0.7-0.81.5-0.9-1.0
Time in novel zone, NPP test1.51.63.01.7-1.7-1.2-1.3-1.2-1.1-1.0-0.9-1.3-0.9-0.91.6-1.0-1.2
Total zone transitions, NPP test1.52.23.4-1.81.81.51.51.51.51.41.41.31.41.4-1.21.71.3
Total locomotion distance, NPP test1.41.92.6-1.31.31.41.41.41.41.41.61.01.61.5-0.91.61.1
Locomotion velocity, NPP test2.94.15.1-2.02.02.12.02.02.12.12.21.62.32.1-1.62.21.8
Intraocular pressure2.73.94.91.5-1.5-2.1-2.1-2.1-2.1-2.1-1.9-1.6-2.0-2.12.1-2.1-2.2
Delta distance traveled before/after self-admin2.12.23.51.3-1.3-1.6-1.5-1.4-1.5-1.6-1.9-1.4-1.8-1.51.0-1.5-1.2
Delta ambulatory time before/after self-admin0.30.30.90.4-0.4-0.6-0.5-0.4-0.5-0.7-0.9-0.5-0.9-0.50.1-0.6-0.3
Parametrial fat weight9.221.727.44.6-4.6-4.8-4.6-4.6-4.7-5.0-5.2-4.3-5.2-4.74.1-4.6-4.2
Pavlov. Cond. lever latency2.32.95.32.3-2.3-1.6-1.7-1.6-1.5-1.5-1.4-2.0-1.5-1.31.8-1.4-1.5
Pavlov. Cond. magazine entry latency0.10.20.8-0.90.90.30.30.30.30.30.30.60.30.1-0.30.20.2
Pavlov. Cond. change in total contacts0.30.31.6-1.31.30.30.30.20.20.10.10.70.2-0.0-0.40.20.1
Pavlov. Cond. index score0.91.22.7-1.71.71.01.00.90.90.90.91.41.00.7-1.00.80.8
Pavlov. Cond. latency score0.91.12.5-1.61.61.01.00.90.80.90.91.31.00.7-1.00.80.8
Pavlov. Cond. lever contacts1.72.04.6-2.22.21.31.31.21.21.11.11.71.21.0-1.41.11.1
Pavlov. Cond. magazine entry number0.30.41.11.0-1.0-0.6-0.6-0.6-0.6-0.6-0.6-0.8-0.7-0.50.5-0.4-0.4
Pavlov. Cond. intertrial magazine entries1.62.03.1-1.01.01.41.41.51.51.41.31.51.31.5-1.81.31.5
Pavlov. Cond. lever-magazine prob. diff.1.82.34.5-2.12.11.41.41.41.31.31.31.81.41.2-1.41.21.3
Pavlov. Cond. response bias1.31.63.2-1.81.81.21.21.21.11.11.11.51.21.0-1.10.91.0
Pavlov. Cond. lever latency1.11.51.81.0-1.0-1.3-1.2-1.3-1.3-1.3-1.3-1.2-1.3-1.31.4-1.1-1.3
Pavlov. Cond. magazine entry latency0.10.10.1-0.30.30.30.30.30.30.30.20.30.20.3-0.40.10.3
Pavlov. Cond. change in total contacts0.40.61.1-0.30.30.80.80.80.80.91.10.81.00.8-0.90.80.7
Pavlov. Cond. index score0.50.71.1-0.50.50.90.80.80.91.01.00.71.00.9-0.90.70.8
Pavlov. Cond. latency score0.50.70.9-0.50.50.90.80.80.90.91.00.80.90.9-0.90.70.8
Pavlov. Cond. lever contacts0.71.01.3-0.70.71.01.01.01.01.11.10.91.11.1-1.10.91.1
Pavlov. Cond. magazine entry number0.10.10.10.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.2-0.2-0.30.4-0.1-0.3
Pavlov. Cond. intertrial magazine entries2.43.64.62.0-2.0-2.0-2.0-2.0-1.9-1.8-1.8-2.1-1.7-1.82.0-1.8-1.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.20.20.60.60.60.60.70.80.40.70.7-0.60.50.6
Pavlov. Cond. response bias1.31.72.2-1.01.01.41.31.31.41.51.51.01.41.4-1.41.21.4
Time in closed arm before self-admin1.21.52.51.6-1.6-1.2-1.3-1.2-1.2-1.1-1.0-1.3-1.1-1.11.3-1.1-1.1
Time in closed arm after self-admin1.71.82.01.4-1.4-1.4-1.4-1.4-1.3-1.4-1.3-1.4-1.4-1.31.2-1.4-1.3
Time in open arm before self-admin0.20.30.5-0.70.70.50.50.50.50.50.50.40.60.4-0.40.40.3
Time in open arm after self-admin2.42.73.5-1.81.81.61.71.71.61.51.21.91.31.5-1.81.41.7
Bone: periosteal estimation0.91.82.8-1.71.71.41.41.31.31.31.41.31.41.3-1.01.41.0
Bone: periosteal perimeter0.40.70.9-0.90.90.90.90.80.80.80.80.80.80.8-0.60.90.7
Bone: post-yield work0.71.01.2-1.01.01.01.01.01.01.01.01.11.00.9-0.90.80.9
Progressive ratio test 1 active lever presses0.91.11.9-1.21.21.11.11.11.01.00.91.30.90.9-1.40.81.1
Progressive ratio test 1 breakpoint1.01.22.0-1.31.31.11.11.11.11.00.91.30.91.0-1.40.81.1
Progressive ratio test 1 inactive lever presses1.31.82.9-1.61.61.31.31.41.31.10.91.70.91.2-1.71.31.5
Progressive ratio test 2 active lever presses0.10.10.2-0.30.30.10.10.00.00.20.30.40.3-0.0-0.3-0.40.0
Progressive ratio test 2 breakpoint0.00.00.2-0.20.20.10.0-0.1-0.00.10.30.30.3-0.1-0.2-0.4-0.1
Progressive ratio test 2 inactive lever presses0.10.20.5-0.60.60.40.40.40.40.40.50.70.50.3-0.60.20.5
Incentive Sensitization - Responses0.00.10.20.3-0.30.1-0.1-0.10.00.20.5-0.10.50.10.2-0.3-0.1
Incentive Sensitization - Breakpoint0.10.10.20.4-0.4-0.1-0.2-0.3-0.10.10.3-0.20.3-0.10.3-0.4-0.3
Sum of active levers in priming session hrs 5-61.41.31.7-1.31.31.11.11.11.11.11.21.01.31.0-0.91.11.0
Progressive ratio1.11.71.81.3-1.3-1.3-1.3-1.2-1.3-1.3-1.2-1.3-1.3-1.21.3-1.3-1.3
Food seeking constrained by brief footshock1.82.23.1-1.41.41.51.51.51.51.51.51.61.31.5-1.71.31.6
Seeking ratio, punishment vs. effort1.42.12.6-1.41.41.41.41.41.41.51.41.51.41.4-1.61.41.5
Retroperitoneal fat weight21.089.597.29.2-9.2-9.6-9.5-9.5-9.6-9.7-9.9-9.2-9.9-9.58.9-9.5-9.1
Reaction time number correct0.50.91.8-0.40.40.90.90.81.01.11.30.91.41.0-0.81.00.8
Reaction time mean minus median0.00.10.3-0.50.50.20.20.20.30.1-0.00.3-0.00.3-0.50.20.4
Reaction time mean minus median AUC0.00.00.0-0.00.0-0.00.00.00.0-0.1-0.20.1-0.10.1-0.10.10.1
Reaction time num false alarms0.30.40.7-0.40.40.70.70.70.60.70.60.70.60.6-0.90.70.8
Reaction time num false alarms AUC0.50.81.1-0.60.60.90.90.90.90.90.90.90.90.8-1.10.91.0
Reaction time trials correct on left0.50.91.8-0.40.40.90.90.81.01.11.30.91.41.0-0.81.00.8
Reaction time trials on left0.50.91.9-0.40.41.00.90.91.01.11.30.91.41.1-0.91.00.8
Reaction time mean0.40.61.40.2-0.2-0.9-0.7-0.8-0.8-0.9-1.2-0.2-1.2-1.00.3-1.1-0.5
Reaction time mean AUC0.30.51.20.1-0.1-0.7-0.6-0.7-0.7-0.8-1.1-0.1-1.0-0.80.2-0.9-0.3
Median of all reaction times0.50.71.70.2-0.2-0.9-0.8-0.9-0.9-1.0-1.3-0.2-1.2-1.10.3-1.2-0.5
Reaction time omissions0.10.10.2-0.20.20.30.30.40.30.20.00.30.00.3-0.40.30.4
Reaction time false alarm rate0.10.10.2-0.30.30.30.30.30.20.20.10.30.10.1-0.40.20.4
Reaction time premature initiation rate0.10.20.30.3-0.3-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.5-0.50.4-0.5-0.4
Reaction time premature initiations0.00.00.10.1-0.10.10.10.10.10.20.30.10.30.1-0.00.10.0
Std. dev. reaction times0.10.20.50.2-0.2-0.5-0.4-0.5-0.5-0.6-0.7-0.3-0.7-0.50.2-0.5-0.3
Reaction time trials completed0.50.91.9-0.40.41.00.90.91.01.11.30.91.41.1-0.91.00.8
Reaction time trials AUC0.61.22.4-0.60.61.11.01.01.11.31.51.11.51.2-1.01.10.9
Run reversals in cocaine runway, females0.10.10.30.5-0.5-0.0-0.1-0.1-0.00.20.3-0.40.30.10.0-0.0-0.1
Run reversals in cocaine runway, males0.50.51.0-0.40.40.70.60.60.70.81.00.40.90.8-0.50.80.6
Latency to leave start box in cocaine runway0.30.30.5-0.70.70.60.60.60.60.50.40.60.50.6-0.60.60.6
Latency to leave start box in cocaine runway, F0.30.40.7-0.80.80.60.60.60.60.60.60.60.60.6-0.50.60.5
Latency to leave start box in cocaine runway, M0.10.10.20.3-0.3-0.3-0.3-0.3-0.3-0.3-0.5-0.2-0.5-0.20.0-0.2-0.1
Std. dev. time between licks in bursts0.00.10.2-0.30.3-0.2-0.2-0.2-0.2-0.2-0.50.1-0.4-0.20.0-0.30.1
Total sessions with >9 infusions0.10.20.5-0.70.70.20.30.30.2-0.0-0.30.5-0.30.1-0.60.10.3
Short access day 1 total inactive lever presses5.06.67.8-2.82.82.52.62.62.52.42.22.82.22.5-2.82.52.6
Short access day 10 total inactive lever presses1.02.53.4-1.31.31.61.61.71.61.51.51.51.41.7-1.71.91.7
Short access day 1 total infusions1.01.32.3-1.51.51.01.11.21.00.70.41.30.40.9-1.51.01.2
Short access day 10 total infusions1.82.33.5-1.91.91.41.51.51.41.31.31.81.21.3-1.71.11.5
Short access total infusions0.20.20.8-0.90.90.30.40.40.30.10.00.7-0.10.2-0.70.20.4
Short access day 1 locomotion1.41.72.9-1.71.71.21.31.31.21.10.91.50.91.1-1.51.11.3
Short access day 10 total locomotion1.52.74.4-2.12.11.61.61.61.61.51.41.71.41.4-1.81.51.6
Short access total locomotion0.10.10.3-0.60.60.10.10.10.1-0.1-0.30.3-0.2-0.0-0.40.00.1
One hour access (0.3 mA shock)0.30.40.8-0.90.90.60.60.50.50.50.50.90.50.4-0.80.10.5
Compulsive drug intake0.50.61.11.1-1.1-0.7-0.7-0.6-0.6-0.8-1.0-0.8-1.0-0.50.7-0.7-0.7
One hour access (shock baseline)1.11.62.4-1.51.51.21.21.11.11.31.41.41.31.0-1.40.91.2
Social response proportion0.50.61.10.9-0.9-0.8-0.7-0.7-0.7-0.9-1.1-0.6-1.1-0.70.5-0.6-0.5
Social responses0.10.10.30.5-0.5-0.2-0.2-0.2-0.2-0.3-0.50.0-0.5-0.2-0.2-0.10.1
Social time0.70.91.61.0-1.0-1.0-0.9-0.9-1.0-1.1-1.3-0.7-1.2-1.00.7-0.9-0.7
Soleus weight5.917.419.1-3.83.84.34.44.44.44.34.24.14.24.3-3.94.24.2
Bone: stiffness0.00.00.0-0.00.00.10.10.10.10.10.10.20.10.0-0.10.00.1
Tibialis anterior weight4.515.417.6-3.63.64.14.14.14.14.13.93.63.94.1-3.64.14.2
Time to tail flick, vehicle, before self-admin0.80.91.11.0-1.0-1.0-1.0-1.0-1.0-0.8-0.6-1.0-0.7-0.91.1-0.9-0.9
Time to tail flick, vehicle, after self-admin2.02.63.21.2-1.2-1.7-1.7-1.8-1.7-1.6-1.5-1.6-1.6-1.71.7-1.6-1.8
Time to tail flick, test, before self-admin0.10.10.2-0.10.10.30.30.30.30.20.10.40.10.3-0.40.20.3
Time to tail flick, test, after self-admin0.10.10.2-0.20.20.40.30.30.30.40.50.10.50.3-0.20.20.3
Delta time to tail flick, vehicle, before/after SA0.00.00.2-0.20.2-0.1-0.2-0.2-0.2-0.2-0.1-0.2-0.1-0.20.3-0.0-0.4
Delta time to tail flick, test, before/after SA1.31.32.1-1.01.01.21.11.11.11.31.40.91.51.1-0.91.11.0
Tibia length2.77.49.31.9-1.9-2.9-2.8-2.9-2.9-3.0-3.0-2.1-3.0-3.12.5-2.8-2.8
Ambulatory time before self-admin0.00.10.30.0-0.00.30.20.20.20.30.40.30.50.20.10.10.0
Ambulatory time after self-admin0.70.81.41.0-1.0-0.9-0.9-0.9-0.9-1.0-1.2-0.6-1.1-0.90.6-1.0-0.7
Bone: tissue strength0.40.40.50.7-0.7-0.6-0.6-0.5-0.6-0.6-0.7-0.6-0.7-0.60.4-0.6-0.5
Total heroin consumption3.33.94.3-1.91.92.12.12.02.12.01.92.12.02.0-1.81.92.0
Bone: trabecular number4.37.08.6-2.92.92.62.72.72.62.52.22.92.22.6-2.82.52.8
Bone: trabecular spacing1.72.32.71.3-1.3-1.6-1.5-1.6-1.6-1.6-1.5-1.6-1.5-1.61.6-1.4-1.6
Bone: trabecular thickness0.70.81.2-1.11.10.90.91.00.90.90.70.80.70.9-0.90.91.0
Bone: trabecular tissue density0.20.30.4-0.40.40.50.50.40.40.60.60.50.60.4-0.60.30.6
Water consumed over 24 hours0.40.50.7-0.80.80.80.80.80.70.70.80.80.80.7-0.80.60.6
Number of responses in last shaping day0.20.20.5-0.10.1-0.4-0.4-0.5-0.5-0.5-0.40.0-0.4-0.60.6-0.5-0.7