Hub : Genes

Nrbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Nrbp1 0.09 0.08 5.4e-03 0.08 0.07 0.04 0.07 4.6e-03 6.7e-03 3.9e-02 6.6e-03
2 Eye gene expression Nrbp1 0.4 0.17 9.0e-05 0.21 0.16 0.11 0.14 3.5e-04 1.9e-03 8.2e-03 3.2e-03
3 Brain gene expression Nrbp1 0.15 0.11 4.8e-13 0.13 0.13 0.13 0.13 4.7e-12 7.1e-12 3.6e-12 3.6e-12
4 LHb gene expression Nrbp1 0.43 0.25 2.4e-07 0.22 0.24 0.24 0.22 6.5e-06 2.0e-06 2.0e-06 5.9e-06
5 pVTA gene expression Nrbp1 0.6 0 0.0e+00 0.3 0.3 0.29 0.3 7.0e-25 3.1e-24 7.0e-24 1.2e-24
6 Adipose gene expression Nrbp1 0.56 0.19 0.0e+00 0.51 0.5 0.51 0.5 5.3e-65 4.5e-64 9.1e-65 5.7e-64
7 NAcc gene expression Nrbp1 0.03 0.02 1.5e-06 0.03 0.04 0.04 0.04 8.8e-06 3.1e-06 1.3e-06 1.4e-06
8 Liver gene expression Nrbp1 0.48 0.37 0.0e+00 0.24 0.25 0.25 0.25 2.6e-26 3.9e-27 2.7e-27 2.0e-27
9 Adipose mRNA stability Nrbp1 0.04 0.04 8.5e-04 0.03 0.01 0.01 0.03 7.9e-04 1.8e-02 7.1e-02 4.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density4.67.99.53.13.12.82.92.92.92.52.9-2.0
Area under the delay curve0.30.31.00.60.90.30.50.20.20.41.0-0.5
BMI with tail0.30.91.3-1.1-0.8-1.1-0.9-1.0-1.0-1.0-0.70.8
BMI without tail0.61.92.6-1.5-1.5-1.6-1.4-1.2-1.2-1.3-1.31.3
Body weight2.19.112.0-3.5-3.0-3.2-3.1-3.0-3.0-2.9-2.72.6
Weight adjusted by age0.00.00.20.3-0.10.50.10.20.1-0.0-0.20.1
Bone surface2.54.65.72.42.42.22.32.32.31.82.1-1.3
Bone volume2.54.55.82.42.32.12.32.32.31.82.1-1.1
Breakpoint value in progressive ratio session0.81.01.80.91.31.21.00.90.80.71.3-0.6
Number of licking bursts0.10.10.30.30.60.10.30.20.20.10.5-0.1
Context. condit. distance diff. score0.00.00.0-0.1-0.0-0.00.00.00.10.10.0-0.1
Locomotion velocity, session 10.10.10.30.1-0.2-0.2-0.10.00.0-0.2-0.30.5
Locomotion distance, session 12.02.53.01.71.51.31.61.61.61.61.6-1.6
Locomotion velocity, session 20.20.20.5-0.5-0.5-0.7-0.5-0.5-0.6-0.2-0.4-0.0
Locomotion distance, session 20.00.00.10.2-0.1-0.00.00.10.10.2-0.2-0.3
Locomotion velocity, session 30.50.60.90.80.71.00.80.90.90.60.7-0.4
Locomotion distance, session 30.80.91.01.01.00.81.01.01.01.00.9-1.0
Stereotopy head waving bouts, day 31.82.12.71.51.31.61.51.51.51.41.3-1.2
Stereotopy head waving duration, day 30.10.10.30.30.20.50.30.30.40.20.2-0.1
Locomotion velocity, session 70.91.01.61.30.91.21.11.21.20.60.80.0
Locomotion distance, session 70.10.20.90.4-0.10.40.20.40.4-0.3-0.10.9
Stereotopy head waving bouts, day 70.10.10.60.20.2-0.10.10.10.10.50.2-0.8
Stereotopy head waving duration, day 70.50.62.00.60.60.50.60.60.51.00.6-1.4
Locomotion velocity, session 80.10.20.40.50.10.60.40.60.60.2-0.00.1
Locomotion distance, session 80.30.50.60.70.50.60.70.70.80.80.6-0.7
Degree of sensitization distance1.11.23.0-0.9-1.0-0.8-0.9-0.9-0.8-1.3-1.01.7
Degree of sensitization stereotypy0.20.20.5-0.4-0.3-0.7-0.4-0.5-0.5-0.0-0.2-0.5
Conditioned locomotion3.03.54.21.81.71.91.91.81.82.01.9-2.0
Cocaine response after cond. corrected0.91.01.70.90.90.91.00.90.91.11.3-1.2
Cocaine response after cond. not corrected1.82.23.21.61.51.21.51.41.41.51.8-1.5
Cocaine response before conditioning1.21.42.51.61.31.11.21.31.21.01.0-0.8
Saline control response0.60.70.91.00.70.90.90.90.90.90.7-0.8
Bone: connectivity density4.46.98.52.82.92.62.72.72.72.42.7-2.0
Bone: cortical apparent density0.60.81.01.01.00.70.90.80.80.91.0-0.9
Bone: cortical area0.60.91.21.01.10.91.11.11.10.61.00.0
Bone: cortical porosity1.21.31.81.01.21.01.11.11.11.20.9-1.3
Bone: cortical porosity1.31.41.61.11.31.11.11.31.31.21.0-1.2
Bone: cortical thickness0.00.00.10.10.2-0.20.10.10.1-0.10.10.3
Bone: cortical thickness1.51.72.01.31.41.41.41.41.41.21.3-1.0
Bone: cortical tissue density0.40.60.80.90.80.60.70.60.70.70.9-0.8
Condit. Reinf. active minus inactive responses0.70.71.2-0.8-0.7-0.8-0.8-0.9-1.0-1.1-0.61.1
Condit. Reinf. active-inactive response ratio0.80.81.2-0.9-0.7-0.8-0.9-1.0-1.0-1.1-0.61.1
Condit. Reinf. active responses0.20.20.50.50.60.20.50.40.30.30.7-0.2
Condit. Reinf. inactive responses1.72.12.41.61.51.21.51.51.51.51.5-1.4
Incentive salience index mean0.00.00.10.20.30.10.20.1-0.0-0.20.30.4
Condit. Reinf. lever presses0.71.01.41.11.10.91.00.90.90.81.2-0.7
Condit. Reinf. active minus inactive responses3.54.65.42.02.22.02.12.12.02.22.2-2.3
Condit. Reinf. active-inactive response ratio1.01.22.30.91.10.81.01.01.01.31.1-1.5
Condit. Reinf. active responses2.83.84.62.12.12.02.02.01.91.82.1-1.5
Condit. Reinf. inactive responses1.31.72.51.61.51.61.41.31.30.81.4-0.3
Condit. Reinf. lever presses2.02.83.11.61.71.71.71.61.61.61.8-1.6
Condit. Reinf. lever reinforcers received2.53.54.22.02.01.91.91.81.81.71.9-1.5
Conditioned reinforcement - actives0.81.33.30.90.61.81.01.31.41.30.4-1.0
Conditioned reinforcement - inactives2.84.06.02.42.11.92.01.92.02.01.7-1.9
Conditioned locomotion0.30.41.60.0-0.60.8-0.00.30.4-0.4-0.91.3
Patch foraging indifference point 0 sec0.61.13.0-0.8-0.6-0.8-0.9-0.9-1.0-1.4-0.81.7
Patch foraging indifference point AUC1.42.03.01.41.41.21.41.71.71.51.1-1.3
Delay disc. indifference point, 0s delay2.22.53.6-1.5-1.3-1.8-1.7-1.9-1.9-1.4-1.31.0
Delay disc. indifference point, 16s delay0.20.31.10.50.70.00.40.20.20.31.0-0.4
Delay disc. indifference point, 2s delay0.10.10.2-0.2-0.2-0.4-0.4-0.4-0.4-0.4-0.40.5
Delay disc. indifference point, 24s delay1.92.15.21.21.80.91.30.80.81.42.3-1.9
Delay disc. indifference point, 4s delay0.00.00.20.40.20.00.10.10.10.20.1-0.3
Delay disc. indifference point, 8s delay0.20.20.70.30.80.20.30.00.00.20.9-0.4
Indifference point function ln k0.00.00.1-0.0-0.00.3-0.0-0.0-0.1-0.1-0.10.0
Indifference point function log k0.00.00.1-0.0-0.00.3-0.0-0.0-0.1-0.1-0.10.0
Patch foraging total patch changes 0 sec0.50.92.7-0.7-0.5-0.7-0.8-0.8-0.9-1.3-0.81.6
Patch foraging total patch changes 12 sec1.11.52.5-1.1-1.0-1.2-1.1-1.1-1.0-1.4-1.21.6
Patch foraging total patch changes 18 sec0.10.20.7-0.3-0.3-0.2-0.3-0.1-0.2-0.6-0.60.8
Patch foraging total patch changes 24 sec0.91.62.7-1.1-1.3-1.0-1.2-1.0-1.0-1.3-1.51.6
Patch foraging total patch changes 6 sec0.10.20.3-0.2-0.1-0.5-0.4-0.3-0.3-0.5-0.40.6
Patch foraging time to switch 0 sec0.00.00.1-0.2-0.2-0.2-0.1-0.3-0.2-0.20.30.2
Patch foraging water rate 0 sec0.00.00.10.10.00.30.00.20.10.1-0.3-0.1
Patch foraging water rate 12 sec0.92.02.4-1.5-1.6-1.3-1.5-1.4-1.4-1.3-1.51.0
Patch foraging water rate 18 sec0.60.91.1-0.9-1.0-1.0-1.0-1.0-0.9-0.8-1.00.7
Patch foraging water rate 24 sec2.23.14.3-2.1-1.9-1.4-1.8-1.8-1.9-1.7-1.61.6
Patch foraging water rate 6 sec1.11.62.0-1.2-1.4-1.4-1.4-1.3-1.3-1.1-1.40.9
Seeking ratio, delayed vs. immediate footshock0.10.20.6-0.1-0.7-0.1-0.3-0.20.1-0.2-0.80.5
Distance traveled before self-admin0.00.00.2-0.1-0.1-0.2-0.00.1-0.10.20.1-0.4
Distance traveled after self-admin1.72.13.0-1.7-1.6-1.6-1.5-1.3-1.4-1.3-1.31.1
Extensor digitorum longus weight4.317.118.64.24.34.24.34.24.24.04.3-3.6
Bone: elastic displacement0.70.81.80.70.91.00.80.60.61.00.9-1.3
Bone: elastic work0.91.21.51.01.21.21.11.00.91.01.2-1.1
Bone: endosteal estimation0.61.32.01.21.21.41.31.31.30.81.1-0.2
Bone: endosteal perimeter0.20.50.80.70.70.90.80.80.80.40.8-0.0
Epididymis fat weight16.657.063.4-8.0-7.5-7.2-7.6-7.7-7.7-7.6-7.47.2
Delta time in closed arm before/after self-admin0.00.00.00.00.10.20.10.20.20.10.1-0.1
Delta time in open arm before/after self-admin0.10.10.20.40.30.40.30.20.30.10.40.1
Diff in mean of infusions in LGA sessions0.00.00.10.20.30.40.10.20.0-0.20.00.3
Delay discount exponential model param0.60.71.7-0.9-1.1-0.6-0.8-0.5-0.5-0.7-1.30.7
Extinction: sum of active levers before priming0.40.41.00.40.90.60.70.60.40.61.0-0.6
Active lever presses in extinction session 60.30.31.00.40.31.00.60.70.60.20.20.2
Bone: final force0.10.20.60.30.30.50.40.50.5-0.10.40.8
Bone: final moment0.20.30.60.40.40.50.50.60.6-0.10.40.8
Food consumed during 24 hour testing period0.10.20.30.50.50.30.50.60.50.40.4-0.3
Glucose0.30.40.6-0.6-0.7-0.5-0.6-0.5-0.6-0.7-0.80.8
Heart weight3.14.86.2-1.9-2.2-2.5-2.1-2.0-2.0-2.2-2.32.3
Delay discount hyperbolic model param0.30.41.0-0.7-0.9-0.4-0.6-0.4-0.4-0.4-1.00.4
Intermittent access intake day 1-15 change0.10.20.4-0.5-0.10.30.10.60.5-0.1-0.50.6
Intermittent access intake escalation0.10.20.6-0.7-0.2-0.0-0.20.30.2-0.3-0.70.7
Intermittent access intake escalation 20.20.31.1-0.2-0.3-0.2-0.10.40.3-0.4-0.81.1
Intermitt. access day 1 inactive lever presses0.31.32.41.51.11.31.11.11.11.00.8-0.9
Intermitt. access day 15 inactive lever presses3.26.69.33.02.02.52.72.92.92.61.8-2.3
Intermitt. access escalation Index0.40.51.1-0.6-0.9-0.8-0.6-0.3-0.4-0.8-0.81.1
Intermittent access day 1 total infusions2.84.46.42.51.92.22.22.02.02.12.0-2.0
Intermittent access day 15 total infusions1.01.52.31.11.01.41.31.51.51.20.8-0.8
Intermittent access terminal intake (last 3 days)1.62.13.11.51.31.61.61.81.71.41.1-1.0
Intermittent access total infusions1.72.03.11.41.31.81.41.31.31.51.2-1.4
Intermittent access day 1 locomotion1.52.02.51.61.51.51.51.31.31.31.5-1.1
Intermittent access day 15 total locomotion0.10.20.40.60.50.60.40.40.40.30.0-0.1
Intermittent access total locomotion0.10.20.60.50.40.80.40.30.30.30.2-0.2
Intermittent access standard deviation0.61.21.71.21.11.31.21.21.31.00.8-0.7
Left kidney weight0.00.00.1-0.3-0.2-0.1-0.2-0.2-0.2-0.1-0.0-0.0
Right kidney weight0.31.52.6-1.3-0.8-1.6-1.3-1.5-1.5-1.1-0.70.8
Cocaine induced anxiety0.20.20.50.50.40.50.50.70.70.30.20.1
Post-drug Anxiety1.01.11.6-1.1-0.9-1.2-1.1-1.1-1.0-0.9-1.10.8
Baseline Anxiety2.73.14.6-1.9-1.6-1.9-1.9-2.2-2.0-1.5-1.61.0
Tail length0.41.72.3-1.5-1.5-1.3-1.4-1.2-1.0-1.2-1.51.3
Length with tail1.98.310.3-3.2-3.0-2.7-2.9-2.9-2.8-2.8-2.92.7
Length without tail0.72.22.9-1.7-1.5-1.2-1.5-1.6-1.6-1.5-1.51.4
Times rat made contact with spout2.12.43.11.51.71.51.61.51.41.41.8-1.4
Lifetime Intake1.72.13.71.51.31.91.51.41.41.51.1-1.3
Liver weight, left3.96.56.9-2.6-2.5-2.6-2.5-2.6-2.5-2.5-2.52.5
Liver weight, right10.418.219.2-4.3-4.4-4.4-4.2-4.3-4.2-4.3-4.24.2
Locomotor activity0.20.30.7-0.3-0.0-0.6-0.5-0.8-0.7-0.6-0.10.5
Locomotor testing distance0.20.30.70.50.80.50.50.40.40.40.8-0.4
Locomotor testing rearing0.40.82.10.81.01.40.90.80.80.71.0-0.4
Locomotion in novel chamber0.60.82.4-1.1-1.2-0.2-0.6-0.5-0.3-0.9-0.71.6
Locomotion in novel chamber post-restriction2.84.65.5-2.3-2.3-2.0-2.2-2.3-2.3-2.1-1.71.9
Fecal boli incidents, locomotor time 10.30.41.30.40.40.30.50.50.60.90.7-1.1
Change in fecal boli incidents, locomotor task4.03.94.7-2.0-1.9-1.9-2.1-2.1-2.2-2.0-2.01.7
Time >=10cm from walls, locomotor time 10.10.10.3-0.5-0.0-0.1-0.2-0.4-0.50.00.3-0.6
Bouts of movement, locomotor time 11.92.12.91.11.31.21.51.51.61.61.7-1.5
Total resting periods, locomotor time 12.12.42.91.31.41.31.61.61.71.71.7-1.6
Rest time, locomotor task time 10.10.10.3-0.3-0.6-0.2-0.3-0.2-0.2-0.4-0.30.5
Distance moved, locomotor task time 10.81.21.5-1.1-0.9-1.2-1.1-1.1-1.2-1.2-0.91.1
Vertical activity count, locomotor time 10.20.40.8-0.9-0.3-0.8-0.7-0.7-0.8-0.5-0.50.2
Time >=10cm from walls, locomotor time 20.10.20.60.5-0.00.80.40.50.60.20.20.2
Bouts of movement, locomotor time 20.00.00.1-0.2-0.2-0.2-0.1-0.1-0.10.1-0.0-0.4
Total resting periods, locomotor time 20.10.10.40.10.10.20.20.20.30.50.2-0.7
Rest time, locomotor task time 21.41.72.21.51.41.21.31.31.31.31.3-1.2
Distance moved, locomotor task time 21.51.83.7-1.2-1.3-1.1-1.2-1.2-1.2-1.6-1.31.9
Vertical activity count, locomotor time 20.60.81.2-1.0-1.1-0.6-0.9-0.8-0.8-0.9-1.11.0
Light reinforcement 12.87.08.83.02.92.42.82.82.82.42.7-1.8
Light reinforcement 23.24.96.22.52.52.02.22.32.32.12.1-1.8
Bone: marrow area0.61.32.01.11.21.41.31.31.30.81.1-0.2
Bone: maximum diameter1.12.12.71.51.71.61.61.61.61.11.5-0.5
Bone: maximum force0.10.30.40.40.40.60.50.60.6-0.00.40.6
Bone: maximum moment0.20.30.50.50.60.70.60.70.70.10.60.6
Mean time between licks in bursts1.43.54.0-1.9-1.8-2.0-1.9-1.9-2.0-1.8-1.91.5
Mean num. licks in bursts0.10.10.20.40.20.40.40.40.40.40.3-0.4
Cd content in liver0.00.00.00.1-0.00.10.10.10.10.20.1-0.2
Co content in liver6.27.27.82.72.82.72.72.72.72.62.8-2.3
Cu content in liver0.10.10.10.30.30.30.30.30.30.20.3-0.2
Fe content in liver0.60.71.30.90.71.10.90.90.90.70.7-0.4
K content in liver0.40.40.70.70.50.50.70.80.80.60.6-0.4
Mg content in liver0.50.50.70.80.60.60.80.80.80.60.8-0.3
Mn content in liver0.10.10.20.2-0.00.40.30.30.30.10.20.1
Na content in liver0.40.40.70.70.60.60.70.80.80.60.5-0.4
Rb content in liver0.00.00.00.10.00.10.10.10.10.00.2-0.0
Se content in liver0.20.30.8-0.3-0.7-0.1-0.4-0.3-0.3-0.6-0.70.9
Sr content in liver0.10.10.2-0.4-0.3-0.5-0.3-0.4-0.4-0.4-0.20.3
Zn content in liver0.80.91.3-0.8-1.0-0.9-0.9-0.9-0.9-1.0-1.01.1
Bone: minimum diameter0.20.31.8-0.2-0.2-0.1-0.1-0.1-0.1-0.7-0.21.3
Time in familiar zone, hab. session 10.80.71.1-0.8-1.0-0.7-0.8-0.7-0.7-0.9-1.01.1
Time in novel zone, hab. session 10.70.70.9-0.9-0.9-0.5-0.8-0.9-0.9-0.9-0.80.7
Total zone transitions, hab. session 10.10.20.30.50.30.40.40.40.40.30.4-0.3
Total locomotion distance, hab. session 10.20.20.50.70.40.50.50.50.50.40.4-0.2
Locomotion velocity, hab. session 11.11.52.11.51.31.11.31.31.31.21.3-1.0
Time in familiar zone, hab. session 20.00.00.2-0.0-0.00.20.10.10.2-0.1-0.10.4
Time in novel zone, hab. session 20.50.50.8-0.7-0.6-0.8-0.7-0.8-0.9-0.7-0.50.4
Total zone transitions, hab. session 20.10.20.30.50.40.30.40.40.30.50.5-0.5
Total locomotion distance, hab. session 20.30.40.80.70.60.30.60.60.60.80.6-0.9
Locomotion velocity, hab. session 20.60.81.30.90.80.50.80.80.81.00.9-1.2
Novel to familiar place preference ratio0.70.81.1-1.1-0.7-1.1-1.0-1.1-1.1-0.7-0.80.2
Novelty place preference1.31.41.9-1.4-1.0-1.3-1.3-1.4-1.4-1.0-1.10.5
Time in novel zone, NPP test1.61.72.2-1.5-1.1-1.4-1.4-1.5-1.5-1.1-1.20.7
Total zone transitions, NPP test1.62.32.61.61.51.31.51.51.51.61.5-1.6
Total locomotion distance, NPP test2.22.93.71.81.61.51.71.71.71.81.7-1.9
Locomotion velocity, NPP test3.75.16.52.32.22.02.22.22.22.42.3-2.5
Intraocular pressure5.27.59.3-3.0-2.5-2.8-2.8-3.0-3.0-2.7-2.22.3
Delta distance traveled before/after self-admin2.02.13.1-1.5-1.6-1.3-1.4-1.2-1.1-1.5-1.61.8
Delta ambulatory time before/after self-admin0.30.41.2-0.6-0.6-0.5-0.4-0.3-0.2-0.7-0.61.1
Parametrial fat weight11.126.130.8-5.2-5.2-5.5-5.1-4.9-4.8-5.1-5.15.0
Pavlov. Cond. lever latency1.72.22.9-1.7-1.6-1.4-1.5-1.5-1.5-1.3-1.41.1
Pavlov. Cond. magazine entry latency0.10.10.20.50.20.20.30.40.30.40.3-0.4
Pavlov. Cond. change in total contacts0.00.00.10.30.20.10.20.20.20.20.2-0.1
Pavlov. Cond. index score0.70.91.41.21.00.81.01.01.00.90.9-0.8
Pavlov. Cond. latency score0.70.91.41.21.00.81.01.01.00.80.9-0.7
Pavlov. Cond. lever contacts1.21.41.91.41.31.11.21.21.21.11.2-0.9
Pavlov. Cond. magazine entry number0.40.60.9-0.9-0.6-0.6-0.8-0.8-0.8-0.7-0.70.6
Pavlov. Cond. intertrial magazine entries1.11.32.11.21.41.11.21.11.10.91.4-0.6
Pavlov. Cond. lever-magazine prob. diff.1.51.82.41.51.31.21.41.41.31.31.4-1.3
Pavlov. Cond. response bias1.41.72.31.51.21.11.31.31.31.31.2-1.3
Pavlov. Cond. lever latency1.52.12.5-1.4-1.5-1.6-1.4-1.4-1.4-1.4-1.51.4
Pavlov. Cond. magazine entry latency0.20.30.60.50.50.80.50.60.60.30.20.0
Pavlov. Cond. change in total contacts0.81.32.41.01.21.31.00.91.01.31.1-1.5
Pavlov. Cond. index score1.11.52.31.21.31.51.21.21.31.21.1-1.1
Pavlov. Cond. latency score1.21.62.41.21.21.51.21.31.31.21.0-1.1
Pavlov. Cond. lever contacts1.11.51.81.11.31.31.21.11.21.21.3-1.3
Pavlov. Cond. magazine entry number0.10.20.5-0.3-0.4-0.7-0.4-0.5-0.5-0.3-0.20.0
Pavlov. Cond. intertrial magazine entries3.45.16.0-2.3-2.1-2.5-2.3-2.3-2.3-2.3-2.02.2
Pavlov. Cond. lever-magazine prob. diff.0.81.01.61.01.11.31.01.01.11.00.8-0.8
Pavlov. Cond. response bias1.72.32.71.41.61.61.51.51.51.51.5-1.4
Time in closed arm before self-admin1.11.32.6-0.9-1.2-0.7-1.1-1.2-1.1-1.4-1.11.6
Time in closed arm after self-admin1.71.83.0-1.2-1.3-0.8-1.3-1.4-1.3-1.5-1.31.7
Time in open arm before self-admin0.30.31.30.30.60.00.40.40.10.70.6-1.1
Time in open arm after self-admin1.51.62.01.31.41.01.31.41.31.21.4-1.1
Bone: periosteal estimation0.92.02.61.51.51.51.61.61.61.01.5-0.3
Bone: periosteal perimeter0.40.81.00.90.90.91.01.01.00.61.0-0.1
Bone: post-yield work0.71.01.71.00.91.31.11.21.20.81.0-0.4
Progressive ratio test 1 active lever presses1.01.32.11.41.31.41.20.90.91.01.0-0.9
Progressive ratio test 1 breakpoint1.11.32.11.41.31.41.20.80.91.11.1-1.0
Progressive ratio test 1 inactive lever presses2.43.54.71.91.52.11.81.81.92.11.3-2.2
Progressive ratio test 2 active lever presses0.10.10.40.20.10.70.30.30.30.1-0.10.2
Progressive ratio test 2 breakpoint0.00.10.30.1-0.00.50.20.20.20.0-0.20.2
Progressive ratio test 2 inactive lever presses0.81.22.51.30.81.61.11.41.41.00.3-0.5
Incentive Sensitization - Responses0.10.10.3-0.0-0.10.30.20.50.5-0.0-0.20.4
Incentive Sensitization - Breakpoint0.10.10.4-0.1-0.30.20.10.40.4-0.2-0.40.6
Sum of active levers in priming session hrs 5-60.80.81.31.11.00.40.90.80.80.81.1-0.7
Progressive ratio0.10.10.6-0.2-0.20.0-0.3-0.2-0.1-0.3-0.80.5
Food seeking constrained by brief footshock3.03.75.12.11.82.31.82.02.02.01.2-2.0
Seeking ratio, punishment vs. effort0.60.81.90.90.90.60.80.80.71.01.0-1.4
Retroperitoneal fat weight22.596.099.1-10.0-9.9-9.6-9.8-9.8-9.7-9.9-9.89.7
Reaction time number correct0.61.11.31.01.00.91.01.01.01.11.1-1.1
Reaction time mean minus median0.00.00.1-0.0-0.3-0.0-0.1-0.2-0.2-0.0-0.3-0.0
Reaction time mean minus median AUC0.00.10.1-0.2-0.3-0.3-0.3-0.4-0.3-0.1-0.4-0.0
Reaction time num false alarms0.10.10.40.20.6-0.10.2-0.0-0.10.10.5-0.3
Reaction time num false alarms AUC0.10.10.60.30.8-0.10.20.0-0.00.10.6-0.3
Reaction time trials correct on left0.61.11.31.01.00.91.01.01.01.11.1-1.1
Reaction time trials on left0.61.11.41.11.10.91.01.11.01.11.1-1.2
Reaction time mean1.21.82.2-1.2-1.1-1.5-1.4-1.4-1.4-1.4-1.41.4
Reaction time mean AUC1.01.52.0-1.0-1.0-1.4-1.2-1.3-1.3-1.3-1.21.3
Median of all reaction times1.42.02.5-1.3-1.1-1.6-1.4-1.4-1.4-1.6-1.41.6
Reaction time omissions0.00.10.20.40.30.20.30.20.20.20.3-0.2
Reaction time false alarm rate0.10.10.3-0.10.2-0.5-0.3-0.5-0.5-0.40.00.4
Reaction time premature initiation rate0.10.20.3-0.4-0.5-0.5-0.5-0.5-0.6-0.1-0.4-0.3
Reaction time premature initiations0.10.21.00.20.10.00.10.1-0.00.50.2-1.0
Std. dev. reaction times0.30.60.8-0.6-0.7-0.8-0.8-0.8-0.8-0.8-0.90.9
Reaction time trials completed0.61.11.41.11.10.91.01.11.01.11.1-1.2
Reaction time trials AUC0.71.31.41.21.21.01.11.21.11.11.2-1.2
Run reversals in cocaine runway, females0.10.10.9-0.2-0.2-0.3-0.2-0.3-0.30.3-0.0-0.9
Run reversals in cocaine runway, males0.50.52.7-0.00.30.30.30.00.10.90.8-1.6
Latency to leave start box in cocaine runway0.50.61.00.90.70.80.70.91.00.70.6-0.3
Latency to leave start box in cocaine runway, F0.30.40.80.80.90.40.60.60.60.50.7-0.3
Latency to leave start box in cocaine runway, M0.10.10.3-0.0-0.50.40.10.20.50.3-0.40.0
Std. dev. time between licks in bursts0.10.10.3-0.2-0.3-0.4-0.2-0.1-0.1-0.3-0.30.5
Total sessions with >9 infusions0.40.41.60.60.31.30.70.60.70.60.3-0.4
Short access day 1 total inactive lever presses7.19.311.93.42.72.93.03.03.03.32.5-3.4
Short access day 10 total inactive lever presses1.84.45.92.32.11.92.02.01.92.21.9-2.4
Short access day 1 total infusions2.63.56.71.91.52.61.91.92.11.91.2-1.5
Short access day 10 total infusions1.72.22.81.61.31.71.51.31.31.61.4-1.7
Short access total infusions0.60.82.10.90.51.50.90.91.00.90.5-0.6
Short access day 1 locomotion1.92.44.51.41.32.11.61.61.71.61.1-1.3
Short access day 10 total locomotion1.01.82.41.51.51.31.41.21.21.31.3-1.2
Short access total locomotion0.00.10.30.30.20.60.20.10.10.10.00.0
One hour access (0.3 mA shock)0.70.81.41.00.71.21.01.11.10.80.5-0.4
Compulsive drug intake0.50.51.5-0.8-0.6-1.2-0.7-0.8-0.9-0.1-0.2-0.7
One hour access (shock baseline)1.01.52.81.31.31.71.31.41.51.00.9-0.4
Social response proportion0.60.61.7-0.6-0.7-0.5-0.7-0.6-0.6-0.9-0.91.3
Social responses0.20.20.7-0.1-0.4-0.4-0.3-0.2-0.2-0.5-0.60.8
Social time0.60.92.2-0.7-1.1-0.4-0.8-0.5-0.5-0.9-1.51.3
Soleus weight4.914.516.53.83.93.63.83.73.63.84.1-3.8
Bone: stiffness0.10.10.40.10.20.10.20.30.3-0.20.10.7
Tibialis anterior weight3.612.314.13.73.73.53.73.53.53.23.7-2.8
Time to tail flick, vehicle, before self-admin1.31.31.9-1.4-1.2-0.8-1.2-1.2-1.3-1.0-1.40.8
Time to tail flick, vehicle, after self-admin3.64.85.8-2.4-2.1-1.8-2.3-2.4-2.4-2.2-2.21.9
Time to tail flick, test, before self-admin0.10.10.30.30.40.20.20.10.10.40.3-0.6
Time to tail flick, test, after self-admin0.10.10.20.30.40.40.20.10.3-0.10.20.4
Delta time to tail flick, vehicle, before/after SA0.20.20.7-0.3-0.2-0.1-0.2-0.3-0.2-0.5-0.20.8
Delta time to tail flick, test, before/after SA1.41.41.81.31.31.21.31.31.31.01.2-0.6
Tibia length3.08.211.3-2.8-2.8-2.8-2.8-2.7-2.6-3.1-2.93.4
Ambulatory time before self-admin0.00.10.40.10.1-0.10.10.20.00.30.2-0.6
Ambulatory time after self-admin1.21.42.1-1.4-1.4-1.4-1.1-0.9-1.0-1.1-1.11.0
Bone: tissue strength0.90.91.2-1.1-0.8-1.1-0.9-1.0-1.0-1.0-0.71.0
Total heroin consumption3.13.75.52.02.31.82.02.01.81.62.2-1.3
Bone: trabecular number3.66.07.32.62.72.32.52.52.52.32.5-2.0
Bone: trabecular spacing2.93.94.8-2.2-2.2-2.2-2.1-2.1-2.1-1.7-1.71.2
Bone: trabecular thickness0.70.91.21.11.11.11.01.11.10.50.80.1
Bone: trabecular tissue density0.30.40.60.70.60.50.70.80.80.70.4-0.5
Water consumed over 24 hours0.50.71.31.01.10.70.90.90.80.61.0-0.3
Number of responses in last shaping day0.10.20.5-0.3-0.40.70.20.40.40.4-0.5-0.2