Hub : Genes

Fam228b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_063261377.1 0.11 0.06 9.9e-07 0.04 0.01 0.04 0.04 5.5e-05 2.4e-02 4.1e-05 8.9e-05
2 Liver isoform ratio XM_063261375.1 0.09 0.06 2.2e-06 0.04 0.01 0.04 0.04 9.4e-06 1.0e-02 4.5e-05 3.4e-05
3 Liver gene expression Fam228b 0.07 0.05 7.9e-04 0.01 0 0.02 0 8.1e-03 1.2e-01 4.7e-03 1.4e-01
4 Brain gene expression Fam228b 0.03 0.03 2.5e-03 0.01 0.02 0.01 0.01 7.4e-02 3.7e-03 2.3e-02 2.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density2.24.19.21.6-1.8-1.23.0
Area under the delay curve0.10.10.20.4-0.2-0.5-0.2
BMI with tail2.07.210.2-3.13.22.8-1.1
BMI without tail1.05.58.0-2.82.82.5-0.2
Body weight2.29.513.0-3.53.63.0-1.9
Weight adjusted by age0.10.20.4-0.60.60.50.1
Bone surface0.61.22.31.0-0.9-0.91.5
Bone volume1.32.64.31.5-1.5-1.32.1
Breakpoint value in progressive ratio session1.01.82.21.5-1.3-1.41.2
Number of licking bursts0.82.42.8-1.71.71.5-1.3
Context. condit. distance diff. score0.70.83.00.3-0.5-0.11.7
Locomotion velocity, session 10.10.10.1-0.20.4-0.1-0.2
Locomotion distance, session 10.50.60.90.9-0.8-0.90.4
Locomotion velocity, session 20.10.10.1-0.40.40.2-0.4
Locomotion distance, session 20.10.20.40.4-0.2-0.6-0.3
Locomotion velocity, session 30.10.10.2-0.30.20.40.4
Locomotion distance, session 30.10.20.4-0.30.20.40.6
Stereotopy head waving bouts, day 32.42.83.61.7-1.6-1.51.9
Stereotopy head waving duration, day 30.20.30.40.6-0.6-0.50.6
Locomotion velocity, session 70.00.00.1-0.00.1-0.10.4
Locomotion distance, session 70.40.50.7-0.80.80.80.0
Stereotopy head waving bouts, day 70.10.20.3-0.40.50.3-0.4
Stereotopy head waving duration, day 70.00.00.1-0.20.10.3-0.2
Locomotion velocity, session 81.11.32.31.0-1.0-0.91.5
Locomotion distance, session 81.31.83.11.2-1.3-1.01.8
Degree of sensitization distance0.60.71.0-0.91.00.7-0.7
Degree of sensitization stereotypy1.21.32.2-1.01.20.7-1.5
Conditioned locomotion1.51.84.60.9-1.2-0.42.1
Cocaine response after cond. corrected0.10.20.40.20.1-0.4-0.6
Cocaine response after cond. not corrected0.30.50.70.7-0.5-0.9-0.7
Cocaine response before conditioning1.21.52.61.4-1.6-1.10.5
Saline control response0.81.11.51.1-1.2-1.00.7
Bone: connectivity density1.32.14.71.2-1.2-1.02.2
Bone: cortical apparent density0.81.32.91.3-0.7-1.7-0.3
Bone: cortical area0.10.20.3-0.30.40.2-0.6
Bone: cortical porosity1.01.12.01.2-1.4-1.00.3
Bone: cortical porosity1.21.32.01.2-1.4-0.90.9
Bone: cortical thickness0.50.82.9-0.30.5-0.1-1.7
Bone: cortical thickness0.50.61.00.9-0.7-1.00.0
Bone: cortical tissue density0.71.12.71.2-0.6-1.6-0.3
Condit. Reinf. active minus inactive responses2.32.64.1-1.51.71.1-2.0
Condit. Reinf. active-inactive response ratio1.51.62.1-1.31.41.0-1.3
Condit. Reinf. active responses0.30.40.8-0.60.60.4-0.9
Condit. Reinf. inactive responses0.81.01.41.0-1.2-0.81.0
Incentive salience index mean0.91.21.8-1.01.10.8-1.3
Condit. Reinf. lever presses0.10.10.20.3-0.4-0.2-0.2
Condit. Reinf. active minus inactive responses0.20.30.40.6-0.7-0.50.2
Condit. Reinf. active-inactive response ratio0.10.10.2-0.2-0.10.4-0.3
Condit. Reinf. active responses0.20.20.30.4-0.4-0.5-0.5
Condit. Reinf. inactive responses0.10.10.20.3-0.1-0.5-0.3
Condit. Reinf. lever presses0.71.01.41.1-1.0-1.2-0.6
Condit. Reinf. lever reinforcers received0.20.30.50.5-0.4-0.6-0.7
Conditioned reinforcement - actives0.93.76.02.2-1.7-2.51.0
Conditioned reinforcement - inactives1.43.95.22.3-2.3-2.01.1
Conditioned locomotion3.55.18.82.7-2.1-3.00.7
Patch foraging indifference point 0 sec0.10.20.6-0.30.10.50.8
Patch foraging indifference point AUC0.41.12.5-1.00.51.60.7
Delay disc. indifference point, 0s delay0.40.41.6-0.10.3-0.1-1.3
Delay disc. indifference point, 16s delay0.00.10.10.3-0.0-0.40.1
Delay disc. indifference point, 2s delay0.30.30.80.4-0.4-0.5-0.9
Delay disc. indifference point, 24s delay2.03.24.11.9-1.5-2.01.7
Delay disc. indifference point, 4s delay0.10.10.20.1-0.40.3-0.4
Delay disc. indifference point, 8s delay0.20.30.70.7-0.4-0.80.3
Indifference point function ln k0.92.74.51.9-1.6-2.10.4
Indifference point function log k0.92.74.51.9-1.6-2.10.4
Patch foraging total patch changes 0 sec0.10.20.5-0.30.10.40.7
Patch foraging total patch changes 12 sec2.63.45.9-2.11.82.4-0.4
Patch foraging total patch changes 18 sec0.51.22.1-1.10.71.41.1
Patch foraging total patch changes 24 sec0.51.62.6-1.51.31.6-0.4
Patch foraging total patch changes 6 sec1.42.44.4-1.81.42.1-0.1
Patch foraging time to switch 0 sec0.10.20.6-0.50.80.1-0.3
Patch foraging water rate 0 sec0.93.55.02.0-2.2-1.61.4
Patch foraging water rate 12 sec0.10.41.40.00.1-0.2-1.2
Patch foraging water rate 18 sec1.02.33.61.8-1.9-1.5-0.2
Patch foraging water rate 24 sec0.00.00.0-0.00.00.00.1
Patch foraging water rate 6 sec0.81.21.81.3-1.3-1.1-0.3
Seeking ratio, delayed vs. immediate footshock0.71.01.7-1.00.71.3-0.9
Distance traveled before self-admin0.00.00.10.0-0.30.2-0.0
Distance traveled after self-admin0.10.10.3-0.30.10.5-0.0
Extensor digitorum longus weight1.24.75.92.4-2.2-2.31.7
Bone: elastic displacement1.21.51.81.4-1.3-1.20.9
Bone: elastic work1.11.51.91.4-1.3-1.30.7
Bone: endosteal estimation0.30.72.40.3-0.60.01.5
Bone: endosteal perimeter0.20.40.8-0.50.30.70.9
Epididymis fat weight9.648.662.1-7.97.87.1-4.5
Delta time in closed arm before/after self-admin0.10.10.40.0-0.20.10.7
Delta time in open arm before/after self-admin0.80.91.3-1.01.21.0-0.4
Diff in mean of infusions in LGA sessions0.10.30.6-0.50.80.4-0.0
Delay discount exponential model param0.30.40.6-0.70.60.7-0.2
Extinction: sum of active levers before priming0.20.31.10.3-0.1-0.41.0
Active lever presses in extinction session 60.10.10.50.0-0.2-0.00.7
Bone: final force0.30.40.6-0.60.60.6-0.8
Bone: final moment0.10.20.3-0.50.40.4-0.6
Food consumed during 24 hour testing period0.00.10.2-0.10.00.3-0.4
Glucose0.61.01.6-1.21.31.0-0.1
Heart weight0.60.91.1-1.00.91.0-0.7
Delay discount hyperbolic model param0.20.20.3-0.50.50.50.0
Intermittent access intake day 1-15 change0.63.54.72.2-2.0-2.11.0
Intermittent access intake escalation0.52.94.02.0-1.8-2.00.8
Intermittent access intake escalation 21.32.32.91.7-1.6-1.61.0
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.10.00.0
Intermitt. access day 15 inactive lever presses0.10.30.60.3-0.80.30.7
Intermitt. access escalation Index0.61.92.6-1.61.61.5-0.5
Intermittent access day 1 total infusions0.20.71.80.8-0.3-1.40.1
Intermittent access day 15 total infusions1.12.65.31.9-1.3-2.30.4
Intermittent access terminal intake (last 3 days)2.13.77.42.2-1.6-2.7-0.1
Intermittent access total infusions2.52.96.61.9-1.2-2.60.2
Intermittent access day 1 locomotion1.42.55.11.7-1.2-2.3-0.7
Intermittent access day 15 total locomotion0.20.91.61.0-0.6-1.3-0.9
Intermittent access total locomotion2.73.27.02.0-1.3-2.6-0.7
Intermittent access standard deviation0.21.31.71.3-1.3-1.10.7
Left kidney weight0.00.20.4-0.60.60.5-0.1
Right kidney weight0.42.53.3-1.81.81.7-0.7
Cocaine induced anxiety0.41.12.80.7-0.5-1.01.7
Post-drug Anxiety1.21.41.9-1.41.41.30.4
Baseline Anxiety2.44.15.2-2.21.82.3-1.7
Tail length0.00.30.50.6-0.5-0.70.0
Length with tail0.10.51.1-0.50.70.3-1.1
Length without tail0.10.71.1-0.80.80.8-1.0
Times rat made contact with spout0.91.02.20.7-1.0-0.31.5
Lifetime Intake2.32.86.11.9-1.3-2.5-0.0
Liver weight, left2.13.79.2-1.41.70.9-3.0
Liver weight, right2.23.96.2-2.12.51.5-1.7
Locomotor activity3.14.86.0-2.52.52.2-1.5
Locomotor testing distance1.43.44.6-2.12.12.0-0.8
Locomotor testing rearing0.10.30.4-0.60.60.6-0.4
Locomotion in novel chamber1.31.73.0-1.01.70.3-1.7
Locomotion in novel chamber post-restriction0.20.51.3-0.40.80.1-1.1
Fecal boli incidents, locomotor time 10.71.82.01.4-1.3-1.41.2
Change in fecal boli incidents, locomotor task1.21.32.1-1.20.91.4-0.9
Time >=10cm from walls, locomotor time 10.70.80.90.9-0.9-0.90.9
Bouts of movement, locomotor time 10.20.20.60.5-0.2-0.80.2
Total resting periods, locomotor time 10.30.30.50.5-0.3-0.70.7
Rest time, locomotor task time 10.10.10.30.10.0-0.30.5
Distance moved, locomotor task time 10.20.50.9-0.60.50.7-0.9
Vertical activity count, locomotor time 10.00.20.90.00.1-0.2-0.9
Time >=10cm from walls, locomotor time 20.71.92.31.4-1.5-1.11.5
Bouts of movement, locomotor time 20.00.00.10.2-0.2-0.2-0.1
Total resting periods, locomotor time 20.00.00.00.0-0.1-0.10.0
Rest time, locomotor task time 20.00.10.2-0.00.1-0.10.4
Distance moved, locomotor task time 20.30.41.00.4-0.4-0.4-1.0
Vertical activity count, locomotor time 20.20.40.80.7-0.5-0.9-0.3
Light reinforcement 10.00.20.40.5-0.4-0.6-0.2
Light reinforcement 21.32.83.82.0-1.9-1.80.7
Bone: marrow area0.30.72.10.4-0.6-0.01.5
Bone: maximum diameter0.10.20.5-0.2-0.10.50.7
Bone: maximum force0.00.10.2-0.30.20.3-0.5
Bone: maximum moment0.00.00.1-0.10.00.2-0.2
Mean time between licks in bursts0.10.71.0-1.00.91.0-0.2
Mean num. licks in bursts1.43.74.41.9-2.1-1.52.1
Cd content in liver0.20.20.3-0.50.50.50.3
Co content in liver1.41.72.41.5-1.4-1.50.3
Cu content in liver0.10.10.2-0.30.50.20.3
Fe content in liver1.51.83.61.1-1.4-0.71.9
K content in liver1.61.52.5-1.41.11.6-0.6
Mg content in liver0.10.10.1-0.30.20.30.1
Mn content in liver0.10.10.3-0.00.3-0.4-0.5
Na content in liver1.01.11.91.2-1.4-1.00.4
Rb content in liver0.91.01.8-0.90.51.41.1
Se content in liver0.20.20.7-0.20.5-0.1-0.8
Sr content in liver1.31.11.31.1-0.9-1.11.1
Zn content in liver1.82.12.6-1.61.51.6-1.0
Bone: minimum diameter0.91.72.2-1.41.51.1-1.1
Time in familiar zone, hab. session 10.80.91.2-1.01.10.7-1.0
Time in novel zone, hab. session 10.10.20.2-0.30.30.40.5
Total zone transitions, hab. session 10.10.20.20.3-0.5-0.20.5
Total locomotion distance, hab. session 10.50.71.01.0-1.0-0.90.3
Locomotion velocity, hab. session 11.01.42.01.4-1.4-1.30.2
Time in familiar zone, hab. session 20.00.00.10.2-0.0-0.30.2
Time in novel zone, hab. session 20.10.10.3-0.40.50.30.1
Total zone transitions, hab. session 20.20.31.0-0.0-0.20.31.0
Total locomotion distance, hab. session 20.30.41.2-0.20.00.41.1
Locomotion velocity, hab. session 20.30.41.2-0.30.00.61.1
Novel to familiar place preference ratio0.00.00.1-0.20.30.1-0.1
Novelty place preference0.20.20.4-0.50.60.3-0.5
Time in novel zone, NPP test0.20.20.4-0.50.60.2-0.3
Total zone transitions, NPP test0.40.61.90.4-0.6-0.11.4
Total locomotion distance, NPP test1.01.32.80.9-1.1-0.71.7
Locomotion velocity, NPP test0.91.22.21.0-1.2-0.61.5
Intraocular pressure0.91.42.4-1.31.61.0-0.7
Delta distance traveled before/after self-admin1.01.11.5-1.11.21.1-0.6
Delta ambulatory time before/after self-admin0.00.00.10.00.1-0.10.3
Parametrial fat weight24.257.073.9-8.28.67.1-6.0
Pavlov. Cond. lever latency0.10.10.2-0.20.20.1-0.5
Pavlov. Cond. magazine entry latency0.10.20.6-0.20.20.30.8
Pavlov. Cond. change in total contacts0.30.41.00.6-0.3-1.00.1
Pavlov. Cond. index score0.10.10.40.0-0.1-0.00.6
Pavlov. Cond. latency score0.10.20.60.0-0.10.00.8
Pavlov. Cond. lever contacts0.00.00.10.2-0.2-0.20.2
Pavlov. Cond. magazine entry number0.30.31.4-0.00.1-0.1-1.2
Pavlov. Cond. intertrial magazine entries0.70.91.11.0-1.1-0.90.8
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.3-0.3-0.20.7
Pavlov. Cond. response bias0.30.41.10.4-0.5-0.31.1
Pavlov. Cond. lever latency0.30.51.0-0.61.00.2-0.7
Pavlov. Cond. magazine entry latency0.10.20.4-0.30.00.70.5
Pavlov. Cond. change in total contacts0.00.10.2-0.1-0.20.40.2
Pavlov. Cond. index score0.20.20.50.3-0.70.10.5
Pavlov. Cond. latency score0.20.40.70.4-0.90.10.7
Pavlov. Cond. lever contacts0.10.10.40.3-0.60.10.3
Pavlov. Cond. magazine entry number0.40.51.00.7-0.4-1.0-0.4
Pavlov. Cond. intertrial magazine entries0.30.61.5-0.30.7-0.3-1.2
Pavlov. Cond. lever-magazine prob. diff.0.10.20.30.2-0.60.30.5
Pavlov. Cond. response bias0.20.30.60.3-0.80.10.8
Time in closed arm before self-admin0.40.71.6-0.90.41.30.1
Time in closed arm after self-admin1.01.21.4-1.21.01.1-1.1
Time in open arm before self-admin0.20.20.40.30.0-0.7-0.6
Time in open arm after self-admin0.10.10.10.3-0.1-0.30.2
Bone: periosteal estimation0.10.20.60.3-0.4-0.10.8
Bone: periosteal perimeter0.10.30.5-0.50.30.70.4
Bone: post-yield work0.91.52.61.1-1.4-0.61.6
Progressive ratio test 1 active lever presses0.61.02.01.1-0.7-1.4-0.4
Progressive ratio test 1 breakpoint0.61.02.01.2-0.8-1.4-0.2
Progressive ratio test 1 inactive lever presses0.20.50.80.8-0.9-0.80.1
Progressive ratio test 2 active lever presses2.83.97.82.3-1.6-2.80.1
Progressive ratio test 2 breakpoint3.24.18.22.3-1.7-2.9-0.1
Progressive ratio test 2 inactive lever presses1.03.24.92.1-2.2-1.80.5
Incentive Sensitization - Responses1.64.48.02.4-1.9-2.80.2
Incentive Sensitization - Breakpoint1.84.17.82.3-1.8-2.8-0.1
Sum of active levers in priming session hrs 5-60.10.10.3-0.10.30.10.5
Progressive ratio0.20.72.0-0.90.41.40.3
Food seeking constrained by brief footshock4.96.18.02.5-2.8-2.12.4
Seeking ratio, punishment vs. effort0.92.02.51.6-1.6-1.51.0
Retroperitoneal fat weight28.7128.3166.0-12.512.910.8-8.6
Reaction time number correct0.10.40.40.6-0.7-0.60.6
Reaction time mean minus median0.10.61.8-0.71.30.0-0.5
Reaction time mean minus median AUC0.21.12.3-1.11.50.5-0.8
Reaction time num false alarms2.23.75.6-2.32.02.4-0.2
Reaction time num false alarms AUC1.63.75.2-2.32.12.2-0.4
Reaction time trials correct on left0.10.40.40.6-0.7-0.60.6
Reaction time trials on left0.10.30.30.6-0.6-0.50.6
Reaction time mean0.10.30.70.10.6-0.8-0.3
Reaction time mean AUC0.10.30.70.10.6-0.9-0.3
Median of all reaction times0.30.51.60.60.1-1.30.1
Reaction time omissions1.42.34.4-1.82.11.3-0.5
Reaction time false alarm rate2.73.75.1-2.32.12.2-0.9
Reaction time premature initiation rate0.10.20.40.0-0.40.40.6
Reaction time premature initiations0.10.40.90.5-0.8-0.10.9
Std. dev. reaction times0.20.82.2-0.91.50.2-0.4
Reaction time trials completed0.10.30.30.6-0.6-0.50.6
Reaction time trials AUC0.10.30.40.6-0.5-0.60.4
Run reversals in cocaine runway, females0.40.51.10.6-0.6-0.41.0
Run reversals in cocaine runway, males0.20.20.30.4-0.4-0.4-0.5
Latency to leave start box in cocaine runway1.72.38.40.4-0.8-0.02.9
Latency to leave start box in cocaine runway, F0.91.13.9-0.40.10.72.0
Latency to leave start box in cocaine runway, M2.12.04.71.0-1.2-0.82.2
Std. dev. time between licks in bursts0.10.10.2-0.40.50.30.2
Total sessions with >9 infusions2.93.67.22.2-1.5-2.7-0.3
Short access day 1 total inactive lever presses1.42.73.51.9-1.8-1.80.9
Short access day 10 total inactive lever presses0.10.93.3-0.40.30.41.8
Short access day 1 total infusions0.61.22.41.3-0.9-1.60.1
Short access day 10 total infusions1.01.73.41.5-1.1-1.80.2
Short access total infusions1.01.43.11.3-0.8-1.8-0.3
Short access day 1 locomotion0.91.43.71.3-0.6-1.9-0.3
Short access day 10 total locomotion0.72.75.11.9-1.4-2.30.1
Short access total locomotion2.74.18.02.3-1.7-2.8-0.5
One hour access (0.3 mA shock)5.06.08.82.7-2.3-3.01.5
Compulsive drug intake0.10.10.2-0.20.00.40.3
One hour access (shock baseline)1.64.17.12.3-1.8-2.70.7
Social response proportion0.40.50.90.7-0.5-0.9-0.5
Social responses0.10.10.3-0.40.50.3-0.1
Social time0.30.51.00.30.1-0.8-1.0
Soleus weight2.67.79.62.9-3.1-2.42.6
Bone: stiffness0.20.30.6-0.50.30.6-0.8
Tibialis anterior weight0.82.73.41.8-1.7-1.71.4
Time to tail flick, vehicle, before self-admin0.40.51.1-0.30.8-0.5-1.1
Time to tail flick, vehicle, after self-admin1.63.24.9-2.12.21.6-0.9
Time to tail flick, test, before self-admin1.31.53.81.3-0.7-2.0-0.2
Time to tail flick, test, after self-admin2.12.23.71.6-1.4-1.90.6
Delta time to tail flick, vehicle, before/after SA0.70.71.1-1.00.81.00.5
Delta time to tail flick, test, before/after SA1.82.23.61.5-1.9-1.01.4
Tibia length0.61.63.9-1.01.10.7-2.0
Ambulatory time before self-admin0.00.00.0-0.0-0.20.2-0.1
Ambulatory time after self-admin0.10.20.6-0.50.30.8-0.1
Bone: tissue strength0.40.41.4-0.20.5-0.2-1.2
Total heroin consumption4.35.06.72.6-2.6-2.21.4
Bone: trabecular number1.73.26.11.5-1.6-1.22.5
Bone: trabecular spacing0.91.44.3-0.60.80.3-2.1
Bone: trabecular thickness0.50.72.60.1-0.20.11.6
Bone: trabecular tissue density0.10.10.2-0.1-0.20.30.5
Water consumed over 24 hours0.10.30.4-0.50.40.50.7
Number of responses in last shaping day0.50.71.20.8-1.1-0.50.8