Hub : Genes

Fam228b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA XM_008764558.3 0.09 0.05 1.2e-09 0.06 0.03 0.06 0.05 9.0e-07 1.1e-04 8.0e-07 1.6e-06
2 Liver alternative polyA XM_008764559.3 0.1 0.05 8.3e-10 0.07 0.04 0.06 0.06 6.0e-08 4.7e-05 1.2e-07 1.7e-07
3 Liver alternative polyA NM_001419693.1 0.08 0.04 2.3e-09 0.06 0.03 0.05 0.04 5.2e-07 8.2e-04 3.3e-06 7.0e-05
4 Liver alternative polyA NM_001419693.1 0.09 0.05 3.0e-09 0.06 0.03 0.05 0.04 6.5e-07 6.2e-04 4.0e-06 2.6e-05
5 Adipose gene expression Fam228b 0.04 0.03 6.5e-03 0.01 0 0 0.01 4.4e-02 2.8e-01 8.2e-02 3.0e-02
6 Brain gene expression Fam228b 0.09 0.14 9.1e-03 0 0.01 0.02 0.01 1.0e-01 4.1e-02 4.5e-03 8.1e-02
7 pVTA alternative TSS XM_008764559.3 0.05 0.04 7.1e-03 0.03 0.03 0.02 0.02 1.3e-02 2.3e-02 4.5e-02 5.4e-02
8 Liver isoform ratio XM_008764559.3 0.04 0.03 4.7e-05 0.02 0.01 0.02 0 1.3e-03 5.0e-02 4.0e-03 2.5e-01
9 Liver gene expression Fam228b 0.05 0.03 2.1e-03 0.01 -0 0.01 0 1.6e-02 6.3e-01 2.6e-02 2.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density3.86.411.73.42.6-2.3-2.33.1-2.93.20.00.0
Area under the delay curve0.00.00.10.2-0.2-0.0-0.00.20.4-0.1-0.10.1
BMI with tail2.16.811.7-3.0-3.43.43.4-2.82.5-1.90.00.0
BMI without tail1.53.15.2-1.7-2.32.22.2-1.42.3-1.80.00.0
Body weight2.18.815.8-3.4-4.03.83.8-3.33.1-1.70.00.0
Weight adjusted by age0.50.51.4-0.8-0.51.21.2-0.7-0.4-0.2-0.40.4
Bone surface1.32.24.62.11.5-1.5-1.52.0-1.51.60.00.0
Bone volume2.44.08.02.82.1-2.0-2.02.6-2.02.20.00.0
Breakpoint value in progressive ratio session3.03.35.12.21.8-1.7-1.72.2-1.61.51.8-1.8
Number of licking bursts1.72.03.5-1.8-1.91.71.7-1.91.3-0.60.00.0
Context. condit. distance diff. score0.81.03.21.10.9-0.6-0.61.0-1.41.80.00.0
Locomotion velocity, session 10.20.20.5-0.4-0.70.70.7-0.40.3-0.40.00.0
Locomotion distance, session 10.10.20.30.50.6-0.5-0.50.6-0.50.20.00.0
Locomotion velocity, session 20.10.10.3-0.4-0.60.40.4-0.50.0-0.30.00.0
Locomotion distance, session 20.00.00.10.1-0.10.10.10.10.1-0.30.00.0
Locomotion velocity, session 30.10.10.6-0.1-0.10.20.2-0.2-0.30.80.00.0
Locomotion distance, session 30.10.10.60.20.00.10.10.0-0.20.80.00.0
Stereotopy head waving bouts, day 32.73.25.52.31.9-1.9-1.92.1-2.11.80.00.0
Stereotopy head waving duration, day 30.40.50.80.70.8-0.8-0.80.7-0.90.70.00.0
Locomotion velocity, session 70.10.10.30.50.1-0.2-0.20.4-0.60.40.00.0
Locomotion distance, session 70.20.20.6-0.4-0.70.70.7-0.50.10.20.00.0
Stereotopy head waving bouts, day 70.00.00.1-0.00.00.10.10.10.2-0.30.00.0
Stereotopy head waving duration, day 70.10.10.20.10.5-0.3-0.30.2-0.30.00.00.0
Locomotion velocity, session 81.01.23.31.21.1-0.9-0.91.1-1.81.50.00.0
Locomotion distance, session 81.42.13.21.81.6-1.4-1.41.6-1.81.80.00.0
Degree of sensitization distance0.50.51.2-0.8-1.11.01.0-0.80.4-0.50.00.0
Degree of sensitization stereotypy0.60.71.4-1.0-0.80.80.8-0.81.0-1.20.00.0
Conditioned locomotion1.82.15.01.61.7-1.4-1.41.5-1.72.20.00.0
Cocaine response after cond. corrected0.10.10.60.1-0.10.20.20.40.8-0.70.00.0
Cocaine response after cond. not corrected0.20.20.70.30.2-0.3-0.30.50.7-0.80.00.0
Cocaine response before conditioning0.60.82.10.61.2-1.5-1.50.4-0.80.20.00.0
Saline control response1.01.32.31.51.4-1.4-1.41.5-0.80.50.00.0
Bone: connectivity density2.43.87.42.72.0-1.8-1.82.6-2.32.30.00.0
Bone: cortical apparent density0.20.31.20.80.2-0.1-0.11.10.5-0.70.00.0
Bone: cortical area0.10.20.5-0.5-0.60.50.5-0.50.7-0.20.00.0
Bone: cortical porosity1.21.32.41.21.6-1.6-1.61.1-1.00.90.00.0
Bone: cortical porosity1.01.12.01.21.4-1.4-1.41.1-0.80.80.00.0
Bone: cortical thickness0.50.92.8-0.9-0.90.80.8-0.71.7-1.30.00.0
Bone: cortical thickness0.40.40.90.90.8-0.8-0.81.0-0.10.10.00.0
Bone: cortical tissue density0.20.31.10.70.1-0.0-0.01.00.6-0.70.00.0
Condit. Reinf. active minus inactive responses2.62.94.5-1.9-2.12.12.1-1.81.9-1.70.00.0
Condit. Reinf. active-inactive response ratio1.51.72.8-1.4-1.61.71.7-1.31.3-1.10.00.0
Condit. Reinf. active responses0.50.60.9-0.9-1.00.90.9-0.80.9-0.60.00.0
Condit. Reinf. inactive responses0.70.91.41.21.1-1.1-1.11.1-0.71.00.00.0
Incentive salience index mean1.11.32.0-1.4-1.41.41.4-1.41.1-0.90.00.0
Condit. Reinf. lever presses0.00.00.1-0.30.1-0.1-0.1-0.30.1-0.10.00.0
Condit. Reinf. active minus inactive responses0.10.10.30.40.5-0.5-0.50.4-0.20.20.00.0
Condit. Reinf. active-inactive response ratio0.00.00.2-0.4-0.10.00.0-0.40.2-0.10.00.0
Condit. Reinf. active responses0.10.10.40.00.1-0.1-0.10.10.5-0.60.00.0
Condit. Reinf. inactive responses0.00.00.20.0-0.10.10.10.10.3-0.50.00.0
Condit. Reinf. lever presses0.20.20.80.30.4-0.6-0.60.50.3-0.90.00.0
Condit. Reinf. lever reinforcers received0.10.10.60.10.0-0.1-0.10.20.6-0.80.00.0
Conditioned reinforcement - actives3.03.03.91.92.0-1.8-1.81.8-1.00.92.0-2.0
Conditioned reinforcement - inactives4.24.87.52.02.7-2.6-2.62.0-1.20.72.4-2.4
Conditioned locomotion4.14.97.02.42.4-2.5-2.52.7-0.5-0.32.5-2.5
Patch foraging indifference point 0 sec0.10.21.10.1-0.1-0.1-0.1-0.2-0.61.10.00.0
Patch foraging indifference point AUC0.20.20.8-0.6-0.10.30.3-0.7-0.50.90.00.0
Delay disc. indifference point, 0s delay0.70.82.1-0.8-0.70.60.6-0.61.4-1.4-0.60.6
Delay disc. indifference point, 16s delay0.00.00.10.30.1-0.1-0.10.3-0.10.20.1-0.1
Delay disc. indifference point, 2s delay0.20.31.30.00.0-0.1-0.10.20.9-1.1-0.10.1
Delay disc. indifference point, 24s delay3.83.66.52.51.8-1.5-1.52.6-1.71.51.9-1.9
Delay disc. indifference point, 4s delay0.10.10.4-0.3-0.1-0.1-0.1-0.30.6-0.2-0.20.2
Delay disc. indifference point, 8s delay0.10.10.40.6-0.1-0.1-0.10.6-0.20.10.2-0.2
Indifference point function ln k1.11.52.81.61.5-1.7-1.71.6-0.50.10.00.0
Indifference point function log k1.11.52.81.61.5-1.7-1.71.6-0.50.10.00.0
Patch foraging total patch changes 0 sec0.10.21.10.20.1-0.2-0.2-0.0-0.71.00.00.0
Patch foraging total patch changes 12 sec0.91.22.9-1.5-1.31.31.3-1.70.30.50.00.0
Patch foraging total patch changes 18 sec0.40.52.80.2-0.20.20.2-0.2-1.21.70.00.0
Patch foraging total patch changes 24 sec0.40.51.0-0.9-0.90.90.9-1.00.30.20.00.0
Patch foraging total patch changes 6 sec0.60.92.3-1.3-1.21.11.1-1.5-0.10.70.00.0
Patch foraging time to switch 0 sec0.20.30.8-0.2-0.80.80.8-0.10.9-0.50.00.0
Patch foraging water rate 0 sec1.62.64.31.72.1-2.0-2.01.6-1.71.40.00.0
Patch foraging water rate 12 sec0.20.31.3-0.5-0.20.20.2-0.21.1-1.20.00.0
Patch foraging water rate 18 sec1.11.53.60.91.8-1.9-1.91.2-0.4-0.60.00.0
Patch foraging water rate 24 sec0.00.00.00.10.1-0.1-0.10.1-0.00.20.00.0
Patch foraging water rate 6 sec0.20.30.80.30.9-0.8-0.80.40.1-0.50.00.0
Seeking ratio, delayed vs. immediate footshock0.91.01.8-1.2-1.00.60.6-1.31.0-0.6-1.21.2
Distance traveled before self-admin0.20.20.8-0.2-0.5-0.1-0.1-0.30.9-0.2-0.60.6
Distance traveled after self-admin0.10.10.2-0.1-0.2-0.3-0.3-0.1-0.40.40.2-0.2
Extensor digitorum longus weight0.93.67.02.62.2-2.2-2.22.6-1.41.30.00.0
Bone: elastic displacement1.01.22.11.41.4-1.3-1.31.5-0.80.70.00.0
Bone: elastic work0.91.12.11.41.3-1.4-1.41.4-0.70.60.00.0
Bone: endosteal estimation0.30.71.71.00.7-0.8-0.80.8-1.31.20.00.0
Bone: endosteal perimeter0.00.10.50.0-0.10.10.1-0.2-0.40.70.00.0
Epididymis fat weight11.526.945.8-6.6-6.66.66.6-6.83.8-2.50.00.0
Delta time in closed arm before/after self-admin0.20.20.4-0.2-0.30.40.4-0.3-0.60.6-0.30.3
Delta time in open arm before/after self-admin0.30.30.6-0.3-0.70.80.8-0.20.5-0.5-0.50.5
Diff in mean of infusions in LGA sessions0.10.10.6-0.00.00.50.50.0-0.70.4-0.00.0
Delay discount exponential model param0.10.10.3-0.5-0.10.30.3-0.50.0-0.2-0.20.2
Extinction: sum of active levers before priming0.50.51.50.60.9-0.3-0.30.7-1.20.60.7-0.7
Active lever presses in extinction session 60.20.21.1-0.20.40.20.2-0.1-1.10.6-0.00.0
Bone: final force0.10.20.6-0.7-0.50.30.3-0.80.6-0.40.00.0
Bone: final moment0.10.10.3-0.5-0.40.20.2-0.60.4-0.20.00.0
Food consumed during 24 hour testing period0.10.10.4-0.60.00.00.0-0.6-0.0-0.10.00.0
Glucose0.10.20.6-0.3-0.60.80.8-0.30.40.20.00.0
Heart weight2.73.87.0-2.6-2.32.22.2-2.61.9-1.50.00.0
Delay discount hyperbolic model param0.00.10.2-0.4-0.10.20.2-0.4-0.20.1-0.10.1
Intermittent access intake day 1-15 change2.72.74.32.11.6-1.9-1.91.9-0.40.81.6-1.6
Intermittent access intake escalation1.91.83.31.81.3-1.5-1.51.5-0.41.11.3-1.3
Intermittent access intake escalation 20.50.51.11.10.5-0.8-0.80.8-0.10.80.5-0.5
Intermitt. access day 1 inactive lever presses0.20.20.6-0.8-0.20.30.3-0.80.5-0.3-0.40.4
Intermitt. access day 15 inactive lever presses0.20.20.7-0.20.4-0.4-0.4-0.4-0.70.80.4-0.4
Intermitt. access escalation Index1.61.42.4-1.0-1.01.31.3-0.81.3-1.6-1.21.2
Intermittent access day 1 total infusions1.51.72.51.11.6-1.4-1.41.2-1.10.21.6-1.6
Intermittent access day 15 total infusions1.92.13.11.61.6-1.8-1.81.6-0.30.21.5-1.5
Intermittent access terminal intake (last 3 days)1.61.72.81.11.5-1.7-1.71.30.1-0.51.5-1.5
Intermittent access total infusions1.82.03.01.31.7-1.5-1.51.5-0.7-0.11.7-1.7
Intermittent access day 1 locomotion2.02.13.21.31.6-1.8-1.81.6-0.3-0.61.6-1.6
Intermittent access day 15 total locomotion0.30.30.90.20.4-1.0-1.00.20.7-0.40.3-0.3
Intermittent access total locomotion1.01.21.60.91.3-1.3-1.31.20.0-0.71.2-1.2
Intermittent access standard deviation0.20.20.40.3-0.0-0.7-0.70.00.60.4-0.00.0
Left kidney weight0.00.10.2-0.10.3-0.4-0.4-0.00.1-0.30.00.0
Right kidney weight0.41.12.2-1.5-1.21.21.2-1.50.9-0.60.00.0
Cocaine induced anxiety1.92.24.11.81.4-1.0-1.01.5-1.62.01.3-1.3
Post-drug Anxiety0.30.31.0-0.2-0.00.70.7-0.4-0.71.0-0.10.1
Baseline Anxiety2.62.73.9-2.0-1.61.41.4-1.91.6-1.6-1.71.7
Tail length0.00.00.10.10.1-0.3-0.30.10.3-0.00.00.0
Length with tail0.20.71.8-0.9-1.00.80.8-0.81.3-0.50.00.0
Length without tail0.00.10.3-0.4-0.30.30.3-0.50.30.10.00.0
Times rat made contact with spout1.21.42.41.31.3-1.2-1.21.2-1.51.50.00.0
Lifetime Intake1.72.02.91.41.7-1.6-1.61.5-0.60.11.6-1.6
Liver weight, left2.74.26.9-2.5-2.22.12.1-2.22.6-2.60.00.0
Liver weight, right3.66.010.8-3.2-3.12.92.9-3.32.0-1.50.00.0
Locomotor activity2.03.25.2-2.2-2.32.32.3-2.11.5-1.10.00.0
Locomotor testing distance1.52.54.9-1.9-2.12.22.2-1.91.0-0.50.00.0
Locomotor testing rearing0.20.30.5-0.7-0.60.70.7-0.60.4-0.30.00.0
Locomotion in novel chamber1.51.93.7-1.2-1.31.51.5-1.01.2-1.9-1.21.2
Locomotion in novel chamber post-restriction0.20.20.7-0.7-0.50.50.5-0.5-0.0-0.8-0.10.1
Fecal boli incidents, locomotor time 13.43.76.22.41.9-2.1-2.12.5-0.90.81.9-1.9
Change in fecal boli incidents, locomotor task2.32.23.7-1.7-1.71.21.2-1.91.4-0.4-1.61.6
Time >=10cm from walls, locomotor time 10.70.71.61.20.6-0.8-0.81.0-0.80.50.7-0.7
Bouts of movement, locomotor time 10.30.30.60.70.5-0.3-0.30.8-0.5-0.10.7-0.7
Total resting periods, locomotor time 10.50.60.90.90.7-0.5-0.51.0-0.90.40.9-0.9
Rest time, locomotor task time 10.20.30.50.60.5-0.2-0.20.7-0.6-0.00.6-0.6
Distance moved, locomotor task time 10.50.50.8-0.9-0.60.60.6-0.80.5-0.6-0.80.8
Vertical activity count, locomotor time 10.40.41.4-0.3-0.4-0.2-0.2-0.21.1-1.2-0.60.6
Time >=10cm from walls, locomotor time 22.12.23.61.91.2-1.7-1.71.6-1.11.31.3-1.3
Bouts of movement, locomotor time 20.00.00.20.0-0.0-0.2-0.20.10.4-0.1-0.10.1
Total resting periods, locomotor time 20.00.00.00.10.1-0.1-0.10.10.10.20.1-0.1
Rest time, locomotor task time 20.10.10.20.40.10.30.30.4-0.40.20.2-0.2
Distance moved, locomotor task time 20.20.21.1-0.40.2-0.3-0.3-0.20.5-1.00.1-0.1
Vertical activity count, locomotor time 20.20.20.40.20.4-0.5-0.50.40.2-0.70.4-0.4
Light reinforcement 10.00.00.10.10.2-0.2-0.20.30.2-0.20.00.0
Light reinforcement 21.62.13.91.81.9-2.0-2.01.9-0.70.40.00.0
Bone: marrow area0.30.71.61.00.7-0.8-0.80.8-1.31.20.00.0
Bone: maximum diameter0.10.10.80.10.1-0.2-0.2-0.2-0.40.90.00.0
Bone: maximum force0.10.10.4-0.5-0.40.20.2-0.60.3-0.20.00.0
Bone: maximum moment0.00.00.1-0.2-0.20.00.0-0.30.1-0.00.00.0
Mean time between licks in bursts0.81.12.2-1.3-1.51.41.4-1.40.0-0.30.00.0
Mean num. licks in bursts3.23.86.02.52.5-2.2-2.22.4-2.11.50.00.0
Cd content in liver0.00.00.1-0.00.2-0.1-0.10.0-0.30.20.00.0
Co content in liver1.11.23.01.11.6-1.7-1.71.2-0.4-0.30.00.0
Cu content in liver0.20.30.7-0.3-0.80.90.9-0.30.20.10.00.0
Fe content in liver0.60.72.70.60.9-0.6-0.60.5-1.21.60.00.0
K content in liver1.91.94.9-2.0-1.51.51.5-2.20.8-0.20.00.0
Mg content in liver0.60.61.3-1.1-1.01.01.0-1.20.5-0.10.00.0
Mn content in liver0.20.20.80.2-0.0-0.2-0.20.40.8-0.90.00.0
Na content in liver0.90.92.40.71.5-1.5-1.50.8-0.50.10.00.0
Rb content in liver0.60.82.2-1.2-0.70.90.9-1.5-0.50.90.00.0
Se content in liver0.30.40.6-0.7-0.70.80.8-0.70.8-0.40.00.0
Sr content in liver0.10.10.30.50.2-0.2-0.20.6-0.00.10.00.0
Zn content in liver4.54.99.5-3.1-2.62.62.6-3.01.9-1.60.00.0
Bone: minimum diameter0.61.22.1-1.3-1.41.31.3-1.31.2-0.80.00.0
Time in familiar zone, hab. session 10.80.81.3-0.9-1.11.11.1-0.71.0-0.90.00.0
Time in novel zone, hab. session 10.10.10.4-0.3-0.30.40.4-0.4-0.30.60.00.0
Total zone transitions, hab. session 10.10.20.50.20.5-0.5-0.50.0-0.70.60.00.0
Total locomotion distance, hab. session 10.20.30.70.50.8-0.8-0.80.6-0.40.00.00.0
Locomotion velocity, hab. session 10.50.71.60.71.3-1.3-1.30.8-0.5-0.10.00.0
Time in familiar zone, hab. session 20.00.00.10.2-0.30.20.20.20.20.00.00.0
Time in novel zone, hab. session 20.10.10.2-0.1-0.40.40.4-0.1-0.10.30.00.0
Total zone transitions, hab. session 20.20.31.50.00.3-0.1-0.1-0.2-0.81.20.00.0
Total locomotion distance, hab. session 20.20.21.40.00.10.00.0-0.2-0.81.20.00.0
Locomotion velocity, hab. session 20.20.31.5-0.10.2-0.0-0.0-0.3-0.91.20.00.0
Novel to familiar place preference ratio0.00.00.00.00.10.00.00.10.0-0.00.00.0
Novelty place preference0.10.10.2-0.4-0.30.40.4-0.30.4-0.40.00.0
Time in novel zone, NPP test0.10.10.2-0.1-0.30.40.4-0.10.2-0.20.00.0
Total zone transitions, NPP test0.30.41.70.50.5-0.4-0.40.3-1.11.30.00.0
Total locomotion distance, NPP test0.71.02.41.11.0-1.0-1.00.9-1.31.50.00.0
Locomotion velocity, NPP test0.70.91.90.91.1-1.1-1.10.8-1.21.40.00.0
Intraocular pressure0.91.33.2-0.9-1.81.71.7-0.91.1-0.60.00.0
Delta distance traveled before/after self-admin0.40.40.8-0.8-0.60.90.9-0.7-0.70.3-0.30.3
Delta ambulatory time before/after self-admin0.20.20.80.30.3-0.2-0.20.4-0.90.70.5-0.5
Parametrial fat weight11.422.335.1-5.5-5.95.85.8-5.25.0-4.00.00.0
Pavlov. Cond. lever latency0.00.10.3-0.1-0.20.10.10.00.4-0.50.00.0
Pavlov. Cond. magazine entry latency0.20.20.90.0-0.40.60.6-0.1-0.50.90.00.0
Pavlov. Cond. change in total contacts0.20.20.90.90.1-0.2-0.20.90.00.00.00.0
Pavlov. Cond. index score0.10.10.50.2-0.00.10.10.1-0.50.70.00.0
Pavlov. Cond. latency score0.10.21.00.2-0.00.10.10.1-0.61.00.00.0
Pavlov. Cond. lever contacts0.10.10.40.10.2-0.1-0.1-0.1-0.50.70.00.0
Pavlov. Cond. magazine entry number0.20.21.2-0.30.1-0.2-0.2-0.10.7-1.10.00.0
Pavlov. Cond. intertrial magazine entries1.11.32.41.51.3-1.4-1.41.5-0.70.70.00.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.80.60.4-0.3-0.30.5-0.70.90.00.0
Pavlov. Cond. response bias0.50.61.70.90.7-0.6-0.60.7-1.11.30.00.0
Pavlov. Cond. lever latency0.30.50.9-0.5-1.00.90.9-0.40.9-0.60.00.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.10.10.00.0-0.3-0.70.50.00.0
Pavlov. Cond. change in total contacts0.00.10.2-0.20.2-0.1-0.1-0.2-0.50.40.00.0
Pavlov. Cond. index score0.20.30.70.20.8-0.7-0.70.1-0.80.60.00.0
Pavlov. Cond. latency score0.30.40.90.30.8-0.7-0.70.2-0.90.70.00.0
Pavlov. Cond. lever contacts0.10.10.2-0.40.2-0.2-0.2-0.4-0.30.30.00.0
Pavlov. Cond. magazine entry number0.10.10.30.40.3-0.3-0.30.50.6-0.50.00.0
Pavlov. Cond. intertrial magazine entries0.60.82.4-0.4-1.10.90.9-0.21.5-1.30.00.0
Pavlov. Cond. lever-magazine prob. diff.0.20.20.60.10.6-0.5-0.50.0-0.80.50.00.0
Pavlov. Cond. response bias0.20.20.70.10.5-0.5-0.5-0.1-0.80.80.00.0
Time in closed arm before self-admin0.10.10.2-0.3-0.0-0.1-0.1-0.40.10.5-0.30.3
Time in closed arm after self-admin1.01.02.4-1.5-0.71.01.0-1.30.2-1.0-0.90.9
Time in open arm before self-admin0.20.20.90.0-0.40.20.20.20.9-0.9-0.40.4
Time in open arm after self-admin0.20.31.01.0-0.0-0.3-0.30.90.60.00.2-0.2
Bone: periosteal estimation0.10.20.60.60.4-0.4-0.40.4-0.50.80.00.0
Bone: periosteal perimeter0.10.10.4-0.4-0.30.20.2-0.60.00.40.00.0
Bone: post-yield work1.01.43.51.21.2-1.2-1.21.0-1.91.50.00.0
Progressive ratio test 1 active lever presses0.80.81.50.31.2-0.9-0.90.6-0.8-0.41.2-1.2
Progressive ratio test 1 breakpoint0.91.01.80.41.3-0.9-0.90.7-0.9-0.41.3-1.3
Progressive ratio test 1 inactive lever presses1.01.11.90.51.4-1.3-1.30.4-0.80.61.3-1.3
Progressive ratio test 2 active lever presses2.12.23.01.71.7-1.7-1.71.7-0.60.21.6-1.6
Progressive ratio test 2 breakpoint2.52.94.01.92.0-1.9-1.92.0-0.80.21.8-1.8
Progressive ratio test 2 inactive lever presses1.92.24.51.31.6-2.1-2.11.1-0.50.81.5-1.5
Incentive Sensitization - Responses2.12.14.42.11.2-1.8-1.82.10.4-0.31.1-1.1
Incentive Sensitization - Breakpoint1.71.73.61.91.0-1.6-1.61.90.7-0.60.8-0.8
Sum of active levers in priming session hrs 5-60.30.31.10.70.1-0.1-0.10.6-0.81.00.4-0.4
Progressive ratio0.20.20.5-0.2-0.60.10.1-0.60.30.5-0.70.7
Food seeking constrained by brief footshock6.27.69.03.02.9-3.0-3.02.7-2.32.32.8-2.8
Seeking ratio, punishment vs. effort1.72.02.81.31.6-1.5-1.51.4-1.20.71.7-1.7
Retroperitoneal fat weight21.370.1113.9-10.2-10.710.510.5-9.97.6-5.80.00.0
Reaction time number correct0.20.30.60.80.6-0.7-0.70.7-0.70.40.00.0
Reaction time mean minus median0.81.12.8-0.4-1.71.61.6-0.31.0-0.60.00.0
Reaction time mean minus median AUC1.11.43.2-0.9-1.81.81.8-0.81.0-0.70.00.0
Reaction time num false alarms1.52.04.5-1.8-1.81.91.9-2.10.20.50.00.0
Reaction time num false alarms AUC1.41.94.0-1.8-1.81.81.8-2.00.40.20.00.0
Reaction time trials correct on left0.20.30.60.80.6-0.7-0.70.7-0.70.40.00.0
Reaction time trials on left0.20.30.50.70.5-0.6-0.60.7-0.60.30.00.0
Reaction time mean0.20.30.80.7-0.60.50.50.90.4-0.70.00.0
Reaction time mean AUC0.20.30.80.8-0.50.40.40.90.4-0.70.00.0
Median of all reaction times0.40.52.41.40.1-0.3-0.31.50.0-0.50.00.0
Reaction time omissions0.71.02.8-0.4-1.71.61.6-0.50.30.10.00.0
Reaction time false alarm rate1.72.45.0-2.1-1.91.91.9-2.20.9-0.20.00.0
Reaction time premature initiation rate0.10.10.6-0.10.3-0.3-0.3-0.3-0.60.80.00.0
Reaction time premature initiations0.30.41.00.40.7-0.7-0.70.3-1.01.00.00.0
Std. dev. reaction times0.81.13.0-0.3-1.71.71.7-0.21.0-0.50.00.0
Reaction time trials completed0.20.30.50.70.5-0.6-0.60.7-0.60.30.00.0
Reaction time trials AUC0.10.20.50.70.4-0.5-0.50.7-0.50.20.00.0
Run reversals in cocaine runway, females0.60.61.00.80.9-0.7-0.70.6-0.70.61.0-1.0
Run reversals in cocaine runway, males0.50.51.00.20.9-0.8-0.80.4-0.2-0.51.0-1.0
Latency to leave start box in cocaine runway1.41.58.21.10.6-0.7-0.70.5-1.62.90.4-0.4
Latency to leave start box in cocaine runway, F0.60.74.30.10.2-0.0-0.0-0.3-1.32.10.2-0.2
Latency to leave start box in cocaine runway, M2.12.04.81.81.2-1.3-1.31.4-1.42.20.9-0.9
Std. dev. time between licks in bursts0.10.10.3-0.3-0.60.50.5-0.50.10.40.00.0
Total sessions with >9 infusions2.42.74.31.42.1-1.7-1.71.7-0.5-0.92.0-2.0
Short access day 1 total inactive lever presses1.41.62.81.01.7-1.4-1.41.1-0.90.31.5-1.5
Short access day 10 total inactive lever presses0.60.71.4-0.5-0.51.11.1-0.6-0.91.2-0.60.6
Short access day 1 total infusions1.31.42.11.31.4-1.2-1.21.3-0.60.41.3-1.3
Short access day 10 total infusions1.71.93.51.31.5-1.9-1.91.3-0.40.31.4-1.4
Short access total infusions1.71.92.91.41.7-1.5-1.51.5-1.00.41.6-1.6
Short access day 1 locomotion2.12.33.41.51.8-1.4-1.41.7-0.90.11.9-1.9
Short access day 10 total locomotion1.31.52.71.51.1-1.3-1.31.6-0.4-0.11.2-1.2
Short access total locomotion3.13.25.12.02.0-1.9-1.92.3-0.8-0.42.0-2.0
One hour access (0.3 mA shock)4.14.87.22.72.4-2.0-2.02.6-1.51.32.3-2.3
Compulsive drug intake0.30.30.7-0.1-0.50.60.6-0.2-0.20.8-0.60.6
One hour access (shock baseline)2.73.14.41.92.1-1.8-1.82.1-0.80.32.0-2.0
Social response proportion0.20.20.70.30.3-0.5-0.50.50.6-0.80.00.0
Social responses0.20.30.6-0.6-0.70.80.8-0.50.4-0.20.00.0
Social time0.20.31.80.20.1-0.3-0.30.50.7-1.30.00.0
Soleus weight2.05.99.52.93.1-2.9-2.92.9-2.42.10.00.0
Bone: stiffness0.20.31.1-0.9-0.50.30.3-1.00.3-0.40.00.0
Tibialis anterior weight0.51.73.41.91.5-1.4-1.41.8-1.21.10.00.0
Time to tail flick, vehicle, before self-admin1.51.62.9-1.2-0.91.71.7-0.80.7-1.6-1.11.1
Time to tail flick, vehicle, after self-admin4.54.87.3-2.3-2.42.72.7-2.10.5-0.8-2.42.4
Time to tail flick, test, before self-admin2.22.13.61.51.8-1.2-1.21.9-1.2-0.31.7-1.7
Time to tail flick, test, after self-admin1.11.22.21.31.1-1.3-1.31.5-0.4-0.41.0-1.0
Delta time to tail flick, vehicle, before/after SA0.70.71.1-0.8-1.00.80.8-1.0-0.30.7-0.90.9
Delta time to tail flick, test, before/after SA1.31.22.91.20.7-1.7-1.71.00.00.60.8-0.8
Tibia length1.02.74.1-2.0-2.01.81.8-1.82.0-1.60.00.0
Ambulatory time before self-admin0.30.30.6-0.4-0.70.10.1-0.50.8-0.7-0.60.6
Ambulatory time after self-admin0.10.10.3-0.4-0.5-0.2-0.2-0.50.10.0-0.10.1
Bone: tissue strength0.70.61.8-0.7-0.90.70.7-0.51.3-1.30.00.0
Total heroin consumption2.83.35.92.41.6-2.3-2.32.2-0.31.11.5-1.5
Bone: trabecular number3.25.09.13.02.4-2.2-2.22.9-2.52.50.00.0
Bone: trabecular spacing1.41.94.7-1.7-1.21.01.0-1.51.8-2.20.00.0
Bone: trabecular thickness0.91.04.01.30.5-0.2-0.21.1-1.42.00.00.0
Bone: trabecular tissue density0.10.10.40.00.1-0.1-0.1-0.2-0.50.60.00.0
Water consumed over 24 hours0.60.71.81.00.7-0.5-0.50.9-1.21.40.00.0
Number of responses in last shaping day1.21.21.81.31.2-1.1-1.11.3-0.60.91.1-1.1