Hub : Genes

Fam228b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_063261377.1 0.11 0.06 9.9e-07 0.04 0.01 0.04 0.04 5.5e-05 2.4e-02 4.1e-05 8.2e-05
2 Liver isoform ratio XM_063261375.1 0.09 0.06 2.2e-06 0.04 0.01 0.04 0.04 9.4e-06 1.0e-02 4.5e-05 3.2e-05
3 Liver gene expression Fam228b 0.07 0.05 7.9e-04 0.01 0 0.02 0 8.1e-03 1.2e-01 4.7e-03 1.4e-01
4 Brain gene expression Fam228b 0.03 0.03 2.5e-03 0.01 0.02 0.01 0.01 7.4e-02 3.7e-03 2.3e-02 2.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density2.44.19.2-1.61.81.23.0
Area under the delay curve0.10.10.2-0.40.20.5-0.2
BMI with tail2.17.210.23.1-3.2-2.8-1.1
BMI without tail1.85.58.02.8-2.8-2.5-0.2
Body weight2.29.513.03.5-3.6-3.0-1.9
Weight adjusted by age0.20.20.40.6-0.6-0.50.1
Bone surface0.71.22.3-1.00.90.91.5
Bone volume1.52.64.3-1.51.51.32.1
Breakpoint value in progressive ratio session1.51.82.2-1.51.31.41.2
Number of licking bursts1.42.42.81.7-1.7-1.5-1.3
Context. condit. distance diff. score0.70.83.0-0.30.50.11.7
Locomotion velocity, session 10.10.10.10.2-0.40.1-0.2
Locomotion distance, session 10.50.60.9-0.90.80.90.4
Locomotion velocity, session 20.10.10.10.4-0.4-0.2-0.4
Locomotion distance, session 20.10.20.4-0.40.20.6-0.3
Locomotion velocity, session 30.10.10.20.3-0.2-0.40.4
Locomotion distance, session 30.10.20.40.3-0.2-0.40.6
Stereotopy head waving bouts, day 32.42.83.6-1.71.61.51.9
Stereotopy head waving duration, day 30.30.30.4-0.60.60.50.6
Locomotion velocity, session 70.00.00.10.0-0.10.10.4
Locomotion distance, session 70.40.50.70.8-0.8-0.80.0
Stereotopy head waving bouts, day 70.20.20.30.4-0.5-0.3-0.4
Stereotopy head waving duration, day 70.00.00.10.2-0.1-0.3-0.2
Locomotion velocity, session 81.11.32.3-1.01.00.91.5
Locomotion distance, session 81.31.83.1-1.21.31.01.8
Degree of sensitization distance0.70.71.00.9-1.0-0.7-0.7
Degree of sensitization stereotypy1.21.32.21.0-1.2-0.7-1.5
Conditioned locomotion1.61.84.6-0.91.20.42.1
Cocaine response after cond. corrected0.10.20.4-0.2-0.10.4-0.6
Cocaine response after cond. not corrected0.40.50.7-0.70.50.9-0.7
Cocaine response before conditioning1.21.52.6-1.41.61.10.5
Saline control response0.81.11.5-1.11.21.00.7
Bone: connectivity density1.32.14.7-1.21.21.02.2
Bone: cortical apparent density0.91.32.9-1.30.71.7-0.3
Bone: cortical area0.10.20.30.3-0.4-0.2-0.6
Bone: cortical porosity1.01.12.0-1.21.41.00.3
Bone: cortical porosity1.21.32.0-1.21.40.90.9
Bone: cortical thickness0.50.82.90.3-0.50.1-1.7
Bone: cortical thickness0.50.61.0-0.90.71.00.0
Bone: cortical tissue density0.81.12.7-1.20.61.6-0.3
Condit. Reinf. active minus inactive responses2.42.64.11.5-1.7-1.1-2.0
Condit. Reinf. active-inactive response ratio1.51.62.11.3-1.4-1.0-1.3
Condit. Reinf. active responses0.30.40.80.6-0.6-0.4-0.9
Condit. Reinf. inactive responses0.91.01.4-1.01.20.81.0
Incentive salience index mean1.01.21.81.0-1.1-0.8-1.3
Condit. Reinf. lever presses0.10.10.2-0.30.40.2-0.2
Condit. Reinf. active minus inactive responses0.20.30.4-0.60.70.50.2
Condit. Reinf. active-inactive response ratio0.10.10.20.20.1-0.4-0.3
Condit. Reinf. active responses0.20.20.3-0.40.40.5-0.5
Condit. Reinf. inactive responses0.10.10.2-0.30.10.5-0.3
Condit. Reinf. lever presses0.71.01.4-1.11.01.2-0.6
Condit. Reinf. lever reinforcers received0.20.30.5-0.50.40.6-0.7
Conditioned reinforcement - actives2.23.76.0-2.21.72.51.0
Conditioned reinforcement - inactives2.73.95.2-2.32.32.01.1
Conditioned locomotion4.05.18.8-2.72.13.00.7
Patch foraging indifference point 0 sec0.10.20.60.3-0.1-0.50.8
Patch foraging indifference point AUC0.71.12.51.0-0.5-1.60.7
Delay disc. indifference point, 0s delay0.40.41.60.1-0.30.1-1.3
Delay disc. indifference point, 16s delay0.00.10.1-0.30.00.40.1
Delay disc. indifference point, 2s delay0.30.30.8-0.40.40.5-0.9
Delay disc. indifference point, 24s delay2.93.24.1-1.91.52.01.7
Delay disc. indifference point, 4s delay0.10.10.2-0.10.4-0.3-0.4
Delay disc. indifference point, 8s delay0.30.30.7-0.70.40.80.3
Indifference point function ln k1.62.74.5-1.91.62.10.4
Indifference point function log k1.62.74.5-1.91.62.10.4
Patch foraging total patch changes 0 sec0.10.20.50.3-0.1-0.40.7
Patch foraging total patch changes 12 sec2.63.45.92.1-1.8-2.4-0.4
Patch foraging total patch changes 18 sec0.81.22.11.1-0.7-1.41.1
Patch foraging total patch changes 24 sec0.91.62.61.5-1.3-1.6-0.4
Patch foraging total patch changes 6 sec1.62.44.41.8-1.4-2.1-0.1
Patch foraging time to switch 0 sec0.10.20.60.5-0.8-0.1-0.3
Patch foraging water rate 0 sec1.63.55.0-2.02.21.61.4
Patch foraging water rate 12 sec0.20.41.4-0.0-0.10.2-1.2
Patch foraging water rate 18 sec1.52.33.6-1.81.91.5-0.2
Patch foraging water rate 24 sec0.00.00.00.0-0.0-0.00.1
Patch foraging water rate 6 sec0.81.21.8-1.31.31.1-0.3
Seeking ratio, delayed vs. immediate footshock0.81.01.71.0-0.7-1.3-0.9
Distance traveled before self-admin0.00.00.1-0.00.3-0.2-0.0
Distance traveled after self-admin0.10.10.30.3-0.1-0.5-0.0
Extensor digitorum longus weight1.24.75.9-2.42.22.31.7
Bone: elastic displacement1.31.51.8-1.41.31.20.9
Bone: elastic work1.21.51.9-1.41.31.30.7
Bone: endosteal estimation0.30.72.4-0.30.6-0.01.5
Bone: endosteal perimeter0.20.40.80.5-0.3-0.70.9
Epididymis fat weight14.248.662.17.9-7.8-7.1-4.5
Delta time in closed arm before/after self-admin0.10.10.4-0.00.2-0.10.7
Delta time in open arm before/after self-admin0.90.91.31.0-1.2-1.0-0.4
Diff in mean of infusions in LGA sessions0.20.30.60.5-0.8-0.4-0.0
Delay discount exponential model param0.30.40.60.7-0.6-0.7-0.2
Extinction: sum of active levers before priming0.30.31.1-0.30.10.41.0
Active lever presses in extinction session 60.10.10.5-0.00.20.00.7
Bone: final force0.30.40.60.6-0.6-0.6-0.8
Bone: final moment0.10.20.30.5-0.4-0.4-0.6
Food consumed during 24 hour testing period0.00.10.20.1-0.0-0.3-0.4
Glucose0.61.01.61.2-1.3-1.0-0.1
Heart weight0.60.91.11.0-0.9-1.0-0.7
Delay discount hyperbolic model param0.20.20.30.5-0.5-0.50.0
Intermittent access intake day 1-15 change1.73.54.7-2.22.02.11.0
Intermittent access intake escalation1.42.94.0-2.01.82.00.8
Intermittent access intake escalation 22.02.32.9-1.71.61.61.0
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.1-0.00.0
Intermitt. access day 15 inactive lever presses0.20.30.6-0.30.8-0.30.7
Intermitt. access escalation Index1.41.92.61.6-1.6-1.5-0.5
Intermittent access day 1 total infusions0.40.71.8-0.80.31.40.1
Intermittent access day 15 total infusions1.82.65.3-1.91.32.30.4
Intermittent access terminal intake (last 3 days)2.83.77.4-2.21.62.7-0.1
Intermittent access total infusions2.52.96.6-1.91.22.60.2
Intermittent access day 1 locomotion2.02.55.1-1.71.22.3-0.7
Intermittent access day 15 total locomotion0.50.91.6-1.00.61.3-0.9
Intermittent access total locomotion2.73.27.0-2.01.32.6-0.7
Intermittent access standard deviation0.61.31.7-1.31.31.10.7
Left kidney weight0.10.20.40.6-0.6-0.5-0.1
Right kidney weight0.52.53.31.8-1.8-1.7-0.7
Cocaine induced anxiety0.81.12.8-0.70.51.01.7
Post-drug Anxiety1.31.41.91.4-1.4-1.30.4
Baseline Anxiety3.54.15.22.2-1.8-2.3-1.7
Tail length0.10.30.5-0.60.50.70.0
Length with tail0.10.51.10.5-0.7-0.3-1.1
Length without tail0.20.71.10.8-0.8-0.8-1.0
Times rat made contact with spout0.91.02.2-0.71.00.31.5
Lifetime Intake2.32.86.1-1.91.32.5-0.0
Liver weight, left2.23.79.21.4-1.7-0.9-3.0
Liver weight, right2.23.96.22.1-2.5-1.5-1.7
Locomotor activity3.14.86.02.5-2.5-2.2-1.5
Locomotor testing distance1.93.44.62.1-2.1-2.0-0.8
Locomotor testing rearing0.20.30.40.6-0.6-0.6-0.4
Locomotion in novel chamber1.31.73.01.0-1.7-0.3-1.7
Locomotion in novel chamber post-restriction0.30.51.30.4-0.8-0.1-1.1
Fecal boli incidents, locomotor time 11.21.82.0-1.41.31.41.2
Change in fecal boli incidents, locomotor task1.31.32.11.2-0.9-1.4-0.9
Time >=10cm from walls, locomotor time 10.80.80.9-0.90.90.90.9
Bouts of movement, locomotor time 10.20.20.6-0.50.20.80.2
Total resting periods, locomotor time 10.30.30.5-0.50.30.70.7
Rest time, locomotor task time 10.10.10.3-0.1-0.00.30.5
Distance moved, locomotor task time 10.30.50.90.6-0.5-0.7-0.9
Vertical activity count, locomotor time 10.10.20.9-0.0-0.10.2-0.9
Time >=10cm from walls, locomotor time 21.31.92.3-1.41.51.11.5
Bouts of movement, locomotor time 20.00.00.1-0.20.20.2-0.1
Total resting periods, locomotor time 20.00.00.0-0.00.10.10.0
Rest time, locomotor task time 20.00.10.20.0-0.10.10.4
Distance moved, locomotor task time 20.30.41.0-0.40.40.4-1.0
Vertical activity count, locomotor time 20.30.40.8-0.70.50.9-0.3
Light reinforcement 10.10.20.4-0.50.40.6-0.2
Light reinforcement 21.82.83.8-2.01.91.80.7
Bone: marrow area0.30.72.1-0.40.60.01.5
Bone: maximum diameter0.10.20.50.20.1-0.50.7
Bone: maximum force0.10.10.20.3-0.2-0.3-0.5
Bone: maximum moment0.00.00.10.1-0.0-0.2-0.2
Mean time between licks in bursts0.30.71.01.0-0.9-1.0-0.2
Mean num. licks in bursts2.33.74.4-1.92.11.52.1
Cd content in liver0.20.20.30.5-0.5-0.50.3
Co content in liver1.51.72.4-1.51.41.50.3
Cu content in liver0.10.10.20.3-0.5-0.20.3
Fe content in liver1.51.83.6-1.11.40.71.9
K content in liver1.61.52.51.4-1.1-1.6-0.6
Mg content in liver0.10.10.10.3-0.2-0.30.1
Mn content in liver0.10.10.30.0-0.30.4-0.5
Na content in liver1.01.11.9-1.21.41.00.4
Rb content in liver0.91.01.80.9-0.5-1.41.1
Se content in liver0.20.20.70.2-0.50.1-0.8
Sr content in liver1.31.11.3-1.10.91.11.1
Zn content in liver1.92.12.61.6-1.5-1.6-1.0
Bone: minimum diameter0.91.72.21.4-1.5-1.1-1.1
Time in familiar zone, hab. session 10.90.91.21.0-1.1-0.7-1.0
Time in novel zone, hab. session 10.20.20.20.3-0.3-0.40.5
Total zone transitions, hab. session 10.10.20.2-0.30.50.20.5
Total locomotion distance, hab. session 10.50.71.0-1.01.00.90.3
Locomotion velocity, hab. session 11.01.42.0-1.41.41.30.2
Time in familiar zone, hab. session 20.00.00.1-0.20.00.30.2
Time in novel zone, hab. session 20.10.10.30.4-0.5-0.30.1
Total zone transitions, hab. session 20.20.31.00.00.2-0.31.0
Total locomotion distance, hab. session 20.30.41.20.2-0.0-0.41.1
Locomotion velocity, hab. session 20.30.41.20.3-0.0-0.61.1
Novel to familiar place preference ratio0.00.00.10.2-0.3-0.1-0.1
Novelty place preference0.20.20.40.5-0.6-0.3-0.5
Time in novel zone, NPP test0.20.20.40.5-0.6-0.2-0.3
Total zone transitions, NPP test0.40.61.9-0.40.60.11.4
Total locomotion distance, NPP test1.01.32.8-0.91.10.71.7
Locomotion velocity, NPP test0.91.22.2-1.01.20.61.5
Intraocular pressure1.01.42.41.3-1.6-1.0-0.7
Delta distance traveled before/after self-admin1.01.11.51.1-1.2-1.1-0.6
Delta ambulatory time before/after self-admin0.00.00.1-0.0-0.10.10.3
Parametrial fat weight24.257.073.98.2-8.6-7.1-6.0
Pavlov. Cond. lever latency0.10.10.20.2-0.2-0.1-0.5
Pavlov. Cond. magazine entry latency0.10.20.60.2-0.2-0.30.8
Pavlov. Cond. change in total contacts0.30.41.0-0.60.31.00.1
Pavlov. Cond. index score0.10.10.4-0.00.10.00.6
Pavlov. Cond. latency score0.10.20.6-0.00.1-0.00.8
Pavlov. Cond. lever contacts0.00.00.1-0.20.20.20.2
Pavlov. Cond. magazine entry number0.30.31.40.0-0.10.1-1.2
Pavlov. Cond. intertrial magazine entries0.70.91.1-1.01.10.90.8
Pavlov. Cond. lever-magazine prob. diff.0.20.20.5-0.30.30.20.7
Pavlov. Cond. response bias0.30.41.1-0.40.50.31.1
Pavlov. Cond. lever latency0.30.51.00.6-1.0-0.2-0.7
Pavlov. Cond. magazine entry latency0.20.20.40.3-0.0-0.70.5
Pavlov. Cond. change in total contacts0.00.10.20.10.2-0.40.2
Pavlov. Cond. index score0.20.20.5-0.30.7-0.10.5
Pavlov. Cond. latency score0.30.40.7-0.40.9-0.10.7
Pavlov. Cond. lever contacts0.10.10.4-0.30.6-0.10.3
Pavlov. Cond. magazine entry number0.40.51.0-0.70.41.0-0.4
Pavlov. Cond. intertrial magazine entries0.40.61.50.3-0.70.3-1.2
Pavlov. Cond. lever-magazine prob. diff.0.10.20.3-0.20.6-0.30.5
Pavlov. Cond. response bias0.20.30.6-0.30.8-0.10.8
Time in closed arm before self-admin0.50.71.60.9-0.4-1.30.1
Time in closed arm after self-admin1.11.21.41.2-1.0-1.1-1.1
Time in open arm before self-admin0.20.20.4-0.3-0.00.7-0.6
Time in open arm after self-admin0.10.10.1-0.30.10.30.2
Bone: periosteal estimation0.10.20.6-0.30.40.10.8
Bone: periosteal perimeter0.20.30.50.5-0.3-0.70.4
Bone: post-yield work1.01.52.6-1.11.40.61.6
Progressive ratio test 1 active lever presses0.81.02.0-1.10.71.4-0.4
Progressive ratio test 1 breakpoint0.81.02.0-1.20.81.4-0.2
Progressive ratio test 1 inactive lever presses0.40.50.8-0.80.90.80.1
Progressive ratio test 2 active lever presses3.43.97.8-2.31.62.80.1
Progressive ratio test 2 breakpoint3.54.18.2-2.31.72.9-0.1
Progressive ratio test 2 inactive lever presses2.03.24.9-2.12.21.80.5
Incentive Sensitization - Responses3.14.48.0-2.41.92.80.2
Incentive Sensitization - Breakpoint3.14.17.8-2.31.82.8-0.1
Sum of active levers in priming session hrs 5-60.10.10.30.1-0.3-0.10.5
Progressive ratio0.50.72.00.9-0.4-1.40.3
Food seeking constrained by brief footshock5.06.18.0-2.52.82.12.4
Seeking ratio, punishment vs. effort1.42.02.5-1.61.61.51.0
Retroperitoneal fat weight30.1128.3166.012.5-12.9-10.8-8.6
Reaction time number correct0.20.40.4-0.60.70.60.6
Reaction time mean minus median0.30.61.80.7-1.3-0.0-0.5
Reaction time mean minus median AUC0.41.12.31.1-1.5-0.5-0.8
Reaction time num false alarms2.63.75.62.3-2.0-2.4-0.2
Reaction time num false alarms AUC2.43.75.22.3-2.1-2.2-0.4
Reaction time trials correct on left0.20.40.4-0.60.70.60.6
Reaction time trials on left0.20.30.3-0.60.60.50.6
Reaction time mean0.20.30.7-0.1-0.60.8-0.3
Reaction time mean AUC0.20.30.7-0.1-0.60.9-0.3
Median of all reaction times0.30.51.6-0.6-0.11.30.1
Reaction time omissions1.62.34.41.8-2.1-1.3-0.5
Reaction time false alarm rate2.73.75.12.3-2.1-2.2-0.9
Reaction time premature initiation rate0.10.20.4-0.00.4-0.40.6
Reaction time premature initiations0.20.40.9-0.50.80.10.9
Std. dev. reaction times0.40.82.20.9-1.5-0.2-0.4
Reaction time trials completed0.20.30.3-0.60.60.50.6
Reaction time trials AUC0.10.30.4-0.60.50.60.4
Run reversals in cocaine runway, females0.50.51.1-0.60.60.41.0
Run reversals in cocaine runway, males0.20.20.3-0.40.40.4-0.5
Latency to leave start box in cocaine runway2.02.38.4-0.40.80.02.9
Latency to leave start box in cocaine runway, F1.01.13.90.4-0.1-0.72.0
Latency to leave start box in cocaine runway, M2.12.04.7-1.01.20.82.2
Std. dev. time between licks in bursts0.10.10.20.4-0.5-0.30.2
Total sessions with >9 infusions3.03.67.2-2.21.52.7-0.3
Short access day 1 total inactive lever presses2.12.73.5-1.91.81.80.9
Short access day 10 total inactive lever presses0.40.93.30.4-0.3-0.41.8
Short access day 1 total infusions0.91.22.4-1.30.91.60.1
Short access day 10 total infusions1.31.73.4-1.51.11.80.2
Short access total infusions1.11.43.1-1.30.81.8-0.3
Short access day 1 locomotion1.11.43.7-1.30.61.9-0.3
Short access day 10 total locomotion1.42.75.1-1.91.42.30.1
Short access total locomotion3.44.18.0-2.31.72.8-0.5
One hour access (0.3 mA shock)5.26.08.8-2.72.33.01.5
Compulsive drug intake0.10.10.20.2-0.0-0.40.3
One hour access (shock baseline)2.74.17.1-2.31.82.70.7
Social response proportion0.40.50.9-0.70.50.9-0.5
Social responses0.10.10.30.4-0.5-0.3-0.1
Social time0.30.51.0-0.3-0.10.8-1.0
Soleus weight2.67.79.6-2.93.12.42.6
Bone: stiffness0.20.30.60.5-0.3-0.6-0.8
Tibialis anterior weight0.82.73.4-1.81.71.71.4
Time to tail flick, vehicle, before self-admin0.50.51.10.3-0.80.5-1.1
Time to tail flick, vehicle, after self-admin2.43.24.92.1-2.2-1.6-0.9
Time to tail flick, test, before self-admin1.51.53.8-1.30.72.0-0.2
Time to tail flick, test, after self-admin2.12.23.7-1.61.41.90.6
Delta time to tail flick, vehicle, before/after SA0.80.71.11.0-0.8-1.00.5
Delta time to tail flick, test, before/after SA2.22.23.6-1.51.91.01.4
Tibia length0.61.63.91.0-1.1-0.7-2.0
Ambulatory time before self-admin0.00.00.00.00.2-0.2-0.1
Ambulatory time after self-admin0.20.20.60.5-0.3-0.8-0.1
Bone: tissue strength0.40.41.40.2-0.50.2-1.2
Total heroin consumption4.35.06.7-2.62.62.21.4
Bone: trabecular number1.93.26.1-1.51.61.22.5
Bone: trabecular spacing1.01.44.30.6-0.8-0.3-2.1
Bone: trabecular thickness0.50.72.6-0.10.2-0.11.6
Bone: trabecular tissue density0.10.10.20.10.2-0.30.5
Water consumed over 24 hours0.20.30.40.5-0.4-0.50.7
Number of responses in last shaping day0.60.71.2-0.81.10.50.8