Hub : Genes

Acsl5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Acsl5 0.08 0.06 2.0e-08 0.04 0.05 0.06 0.06 1.7e-06 6.0e-08 4.1e-09 9.1e-09
2 Liver gene expression Acsl5 0.05 0.04 2.3e-05 0.04 0.03 0.04 0.03 4.7e-05 1.5e-04 6.4e-05 1.0e-04
3 pVTA gene expression Acsl5 0.03 0.02 9.0e-03 0.03 0.02 0.02 0.02 2.5e-03 1.0e-02 6.5e-03 6.4e-03
4 Adipose gene expression Acsl5 0.02 0.02 5.7e-03 0.02 0.01 0.02 0.02 2.5e-03 1.5e-02 1.2e-03 1.5e-03
5 OFC gene expression Acsl5 0.28 0.16 2.2e-05 0.17 0.17 0.15 0.14 7.0e-05 7.0e-05 2.4e-04 3.7e-04
6 Liver mRNA stability Acsl5 0.07 0.05 2.6e-09 0.06 0.07 0.07 0.06 1.3e-07 2.9e-08 3.7e-08 1.0e-07
7 PL mRNA stability Acsl5 0.04 0.03 4.5e-03 0.02 0.02 0.01 0.02 1.2e-03 5.9e-03 2.2e-02 4.2e-03
8 IC intron excision ratio chr1_264299839_264315405 0.07 0.06 5.8e-03 0.04 0.02 0.04 0.04 1.1e-02 3.7e-02 5.8e-03 1.0e-02
9 IC mRNA stability Acsl5 0.08 0.06 3.0e-03 0.05 0.04 0.02 0.03 4.0e-03 6.5e-03 4.6e-02 1.7e-02
10 NAcc intron excision ratio chr1_264299839_264315405 0.02 0.02 1.7e-03 0.02 0.02 0.01 0.01 9.1e-04 1.3e-03 2.3e-03 2.3e-03
11 pVTA mRNA stability Acsl5 0.08 0.06 3.2e-05 0.06 0.06 0.05 0.06 3.2e-05 3.1e-05 3.4e-05 2.4e-05
12 PL isoform ratio XM_039093168.2 0.46 0.21 5.0e-03 -0 0.01 0.01 0.01 3.9e-01 5.2e-02 1.2e-02 5.1e-02
13 PL intron excision ratio chr1_264299839_264315405 0.04 0.03 4.2e-03 0.01 0.02 0.02 0.01 8.9e-03 4.8e-03 3.2e-03 2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.72.96.62.61.92.11.7-1.71.3-2.02.0-1.81.80.61.0-0.2
Area under the delay curve0.81.02.01.10.81.10.4-0.60.3-1.41.4-1.41.4-0.41.00.8
BMI with tail7.124.350.67.07.16.86.8-6.76.3-2.01.8-1.92.24.1-0.7-2.8
BMI without tail3.711.326.34.55.14.74.7-4.64.3-1.21.1-1.31.52.21.6-1.7
Body weight7.733.969.78.48.38.27.8-7.97.3-2.82.6-2.73.14.60.6-2.5
Weight adjusted by age3.35.010.32.43.02.93.2-2.82.90.5-0.50.0-0.21.91.0-3.2
Bone surface0.61.12.71.61.51.31.5-1.11.0-0.60.6-0.90.60.80.3-0.6
Bone volume2.34.19.73.12.72.72.6-2.52.2-1.51.4-1.61.31.50.2-0.9
Breakpoint value in progressive ratio session1.11.43.50.90.80.80.2-0.4-0.0-1.71.7-1.91.7-0.80.91.1
Number of licking bursts0.71.23.30.91.00.60.2-0.3-0.0-1.71.7-1.61.8-0.50.21.0
Context. condit. distance diff. score0.60.72.0-0.8-0.5-0.6-0.20.5-0.11.1-1.01.3-1.2-0.11.4-1.0
Locomotion velocity, session 11.71.84.2-1.6-1.6-1.8-2.11.9-2.0-0.60.7-0.40.5-1.40.0-0.2
Locomotion distance, session 10.30.41.0-0.8-0.7-0.8-0.50.6-0.40.5-0.51.0-0.7-0.00.5-0.8
Locomotion velocity, session 21.41.63.9-1.0-1.1-1.1-0.30.7-0.31.7-1.72.0-1.90.6-0.1-1.7
Locomotion distance, session 21.01.32.51.61.51.51.4-1.61.5-0.60.6-0.10.61.10.5-1.2
Locomotion velocity, session 30.30.32.4-0.00.0-0.10.10.00.10.3-0.30.7-0.00.01.5-0.9
Locomotion distance, session 30.80.95.20.10.30.30.6-0.50.80.7-0.71.5-0.70.51.2-2.3
Stereotopy head waving bouts, day 30.20.31.40.30.30.3-0.0-0.30.2-0.50.5-0.40.60.1-1.2-0.8
Stereotopy head waving duration, day 30.70.81.6-0.9-0.8-1.1-1.31.1-1.3-0.60.6-0.60.7-1.1-0.70.5
Locomotion velocity, session 70.20.21.60.40.10.30.3-0.10.1-0.40.4-0.40.4-0.11.3-0.3
Locomotion distance, session 70.20.31.6-0.1-0.3-0.10.10.10.10.5-0.50.8-0.60.31.3-0.4
Stereotopy head waving bouts, day 70.10.10.30.20.40.10.1-0.10.0-0.40.4-0.40.5-0.1-0.50.2
Stereotopy head waving duration, day 70.40.51.20.61.00.40.4-0.40.2-0.90.8-1.01.1-0.1-0.50.9
Locomotion velocity, session 80.91.12.6-1.3-1.5-1.6-1.21.4-1.20.9-0.81.0-0.7-0.2-0.20.0
Locomotion distance, session 80.40.73.0-0.4-0.3-0.40.10.20.10.9-0.91.3-1.00.21.7-0.9
Degree of sensitization distance0.90.94.3-0.6-0.9-0.9-0.91.1-1.3-0.40.4-1.00.4-0.80.12.1
Degree of sensitization stereotypy0.20.20.70.30.50.30.1-0.20.0-0.70.7-0.80.8-0.30.30.5
Conditioned locomotion0.10.10.2-0.0-0.3-0.2-0.10.00.10.3-0.30.2-0.20.3-0.4-0.3
Cocaine response after cond. corrected1.21.42.9-1.7-1.2-1.2-1.01.1-0.81.4-1.31.2-1.3-0.81.5-0.2
Cocaine response after cond. not corrected1.82.14.6-2.1-1.8-1.7-1.61.6-1.41.4-1.41.3-1.3-1.00.80.4
Cocaine response before conditioning0.60.72.3-0.5-0.8-0.8-0.91.0-1.0-0.30.4-0.40.5-0.4-1.51.1
Saline control response0.71.01.8-1.2-1.3-1.3-1.01.1-0.90.9-0.91.3-1.2-0.2-0.4-0.0
Bone: connectivity density0.10.11.40.3-0.20.00.30.2-0.2-0.20.2-0.20.2-0.11.2-0.1
Bone: cortical apparent density3.14.310.8-2.0-1.7-1.6-0.51.1-0.43.2-3.23.3-3.20.6-0.2-1.5
Bone: cortical area4.77.216.13.74.03.43.2-3.22.7-2.32.2-2.52.21.21.5-0.7
Bone: cortical porosity0.50.51.60.4-0.10.1-0.20.1-0.3-1.11.1-1.01.3-0.60.90.4
Bone: cortical porosity1.11.13.30.90.40.60.1-0.40.0-1.61.6-1.61.8-0.61.20.6
Bone: cortical thickness2.33.88.02.72.82.52.6-2.52.3-1.11.0-1.10.91.41.5-1.0
Bone: cortical thickness1.61.93.51.71.91.61.9-1.81.8-0.10.1-0.00.11.8-0.6-1.3
Bone: cortical tissue density3.34.410.9-2.2-1.8-1.7-0.61.3-0.63.2-3.23.3-3.20.6-0.3-1.4
Condit. Reinf. active minus inactive responses0.80.93.3-0.8-0.3-0.4-0.90.6-0.7-0.80.8-0.20.7-1.51.8-1.2
Condit. Reinf. active-inactive response ratio0.80.92.5-1.2-0.7-0.8-1.11.0-1.0-0.40.40.00.3-1.61.5-0.9
Condit. Reinf. active responses1.01.23.10.10.40.5-0.3-0.2-0.1-1.71.7-0.91.6-1.21.8-1.4
Condit. Reinf. inactive responses1.11.33.71.00.81.00.3-0.70.4-1.91.9-1.41.9-0.50.8-0.4
Incentive salience index mean1.11.33.6-1.4-1.0-0.9-1.41.2-1.2-0.60.7-0.00.6-1.91.7-0.9
Condit. Reinf. lever presses0.70.92.0-1.2-1.2-1.0-1.41.2-1.3-0.50.5-0.10.6-1.40.6-0.0
Condit. Reinf. active minus inactive responses3.24.29.5-0.80.4-0.6-1.51.1-1.7-2.72.8-2.52.4-3.12.91.3
Condit. Reinf. active-inactive response ratio2.52.98.5-1.4-0.1-1.0-1.71.4-1.8-1.71.8-1.61.5-2.92.51.3
Condit. Reinf. active responses2.83.99.40.31.00.3-0.60.3-1.0-3.03.1-2.82.8-2.42.70.9
Condit. Reinf. inactive responses0.91.12.51.10.70.90.5-0.50.2-1.51.5-1.51.6-0.41.40.0
Condit. Reinf. lever presses1.31.74.40.10.50.1-0.50.4-0.8-2.12.1-2.01.7-1.81.50.8
Condit. Reinf. lever reinforcers received2.63.78.50.10.80.2-0.70.4-1.1-2.92.9-2.72.5-2.52.80.9
Conditioned reinforcement - actives0.40.61.7-0.2-0.10.0-0.50.3-0.6-1.11.1-1.00.9-1.11.30.4
Conditioned reinforcement - inactives0.50.81.60.80.81.00.5-0.60.4-1.21.2-1.21.2-0.51.0-0.5
Conditioned locomotion0.30.52.50.3-0.1-0.10.4-0.10.30.6-0.60.6-0.70.9-1.60.8
Patch foraging indifference point 0 sec1.62.95.92.32.42.42.1-2.32.1-1.01.0-1.01.11.00.4-1.0
Patch foraging indifference point AUC1.01.54.01.20.40.8-0.0-0.3-0.1-2.01.9-2.02.00.0-1.10.4
Delay disc. indifference point, 0s delay1.01.13.41.81.21.31.6-1.21.1-0.50.5-0.70.60.90.30.1
Delay disc. indifference point, 16s delay0.60.61.60.20.10.4-0.40.1-0.4-1.11.1-1.31.1-0.80.61.1
Delay disc. indifference point, 2s delay0.10.10.60.40.10.20.3-0.20.2-0.10.00.10.00.4-0.50.8
Delay disc. indifference point, 24s delay1.51.74.40.70.70.9-0.5-0.3-0.2-2.02.0-2.02.1-0.70.21.5
Delay disc. indifference point, 4s delay0.60.64.10.10.20.3-0.3-0.0-0.2-0.80.8-0.80.9-0.82.00.7
Delay disc. indifference point, 8s delay2.22.64.72.21.92.11.4-1.51.0-1.91.9-1.81.90.01.00.5
Indifference point function ln k0.40.62.8-0.9-0.4-0.8-0.40.5-0.20.9-0.91.0-0.9-0.31.70.3
Indifference point function log k0.40.62.8-0.9-0.4-0.8-0.40.5-0.20.9-0.91.0-0.9-0.31.70.3
Patch foraging total patch changes 0 sec1.62.95.72.42.42.42.0-2.32.0-1.31.2-1.21.30.90.2-0.8
Patch foraging total patch changes 12 sec1.21.53.41.51.11.40.6-1.00.7-1.81.8-1.61.8-0.00.5-0.0
Patch foraging total patch changes 18 sec2.64.08.62.51.92.11.1-1.71.1-2.92.9-2.72.90.30.00.2
Patch foraging total patch changes 24 sec1.93.310.11.81.01.60.5-0.90.4-2.82.7-2.93.2-0.70.20.8
Patch foraging total patch changes 6 sec2.74.18.02.82.82.72.2-2.52.2-1.81.8-1.81.81.00.3-0.9
Patch foraging time to switch 0 sec0.51.12.2-1.5-1.1-1.3-0.81.0-0.71.2-1.11.2-1.1-0.51.00.6
Patch foraging water rate 0 sec0.40.92.21.51.01.20.9-1.00.9-1.01.0-0.70.70.6-0.7-1.0
Patch foraging water rate 12 sec0.51.01.91.31.41.20.8-1.10.9-1.11.1-1.00.90.3-0.2-0.6
Patch foraging water rate 18 sec0.40.61.70.91.30.91.1-1.01.00.0-0.10.2-0.10.70.0-0.9
Patch foraging water rate 24 sec1.72.45.52.32.42.11.9-1.91.7-1.11.1-0.90.90.90.6-0.9
Patch foraging water rate 6 sec0.71.04.00.91.00.40.9-0.70.90.2-0.20.8-0.51.4-2.0-1.1
Seeking ratio, delayed vs. immediate footshock0.10.10.6-0.2-0.3-0.5-0.30.3-0.20.2-0.20.30.10.4-0.40.8
Distance traveled before self-admin2.43.18.0-0.8-0.6-0.60.60.10.52.8-2.82.7-2.81.5-0.9-2.1
Distance traveled after self-admin2.12.55.10.50.40.51.5-0.81.32.2-2.31.9-2.22.1-1.6-1.5
Extensor digitorum longus weight0.41.63.31.81.21.61.2-1.51.3-1.31.2-1.11.50.80.2-0.8
Bone: elastic displacement0.40.44.50.1-0.00.30.1-0.10.0-0.50.5-0.40.4-0.62.10.2
Bone: elastic work1.21.53.11.31.21.41.8-1.61.70.6-0.60.6-0.61.41.1-1.1
Bone: endosteal estimation1.43.26.42.52.52.32.0-2.01.6-1.61.6-1.91.70.8-0.1-0.4
Bone: endosteal perimeter2.14.411.53.03.42.62.8-2.52.2-1.51.4-1.71.41.3-0.5-0.7
Epididymis fat weight7.224.547.26.96.86.75.8-6.05.1-4.24.1-4.44.52.22.0-1.6
Delta time in closed arm before/after self-admin1.11.03.9-0.20.10.20.5-0.40.61.1-1.11.1-1.11.3-1.5-2.0
Delta time in open arm before/after self-admin1.11.12.61.21.01.00.6-0.60.2-1.21.2-1.61.3-0.30.81.6
Diff in mean of infusions in LGA sessions1.21.43.5-1.9-1.4-1.4-1.61.4-1.30.1-0.10.2-0.1-1.51.5-0.4
Delay discount exponential model param1.01.12.2-1.0-0.9-1.1-0.30.6-0.31.4-1.41.4-1.50.4-1.0-0.9
Extinction: sum of active levers before priming1.11.23.0-0.1-0.4-0.3-0.90.6-1.0-1.41.5-1.51.5-1.00.41.7
Active lever presses in extinction session 60.40.41.10.90.70.70.6-0.50.4-0.40.4-0.60.50.6-1.00.6
Bone: final force1.11.84.51.92.11.61.8-1.61.4-0.90.8-0.80.91.1-0.6-1.0
Bone: final moment1.52.55.72.32.42.02.0-1.91.7-1.11.1-1.01.11.2-0.3-1.0
Food consumed during 24 hour testing period0.30.42.70.10.30.10.2-0.10.2-0.20.20.5-0.1-0.21.6-1.2
Glucose1.21.93.81.71.51.61.9-1.82.00.3-0.40.5-0.51.8-1.3-1.1
Heart weight2.13.27.12.02.32.32.1-2.01.8-1.01.0-0.91.00.22.7-2.2
Delay discount hyperbolic model param0.70.81.5-0.9-0.8-1.0-0.30.6-0.41.2-1.21.2-1.20.2-1.0-0.6
Intermittent access intake day 1-15 change0.91.93.51.81.91.91.6-1.71.5-1.11.0-1.01.10.60.7-1.0
Intermittent access intake escalation0.91.93.61.91.91.91.6-1.71.5-1.11.1-1.11.20.60.7-1.1
Intermittent access intake escalation 20.91.02.11.41.31.41.2-1.21.0-0.80.8-0.90.90.50.4-0.5
Intermitt. access day 1 inactive lever presses0.82.85.22.21.82.11.2-1.40.9-2.22.2-2.22.3-0.20.30.8
Intermitt. access day 15 inactive lever presses0.20.41.40.10.40.50.1-0.1-0.1-0.70.7-0.90.9-0.81.2-0.0
Intermitt. access escalation Index0.30.41.50.70.30.20.6-0.50.60.4-0.40.7-0.61.1-1.2-0.3
Intermittent access day 1 total infusions0.40.72.10.80.60.50.1-0.3-0.0-1.41.4-1.21.1-0.60.80.4
Intermittent access day 15 total infusions1.01.42.71.31.21.20.8-0.90.6-1.51.5-1.41.5-0.41.6-0.6
Intermittent access terminal intake (last 3 days)0.50.61.10.90.80.80.6-0.60.4-1.01.0-1.01.0-0.21.0-0.1
Intermittent access total infusions1.01.12.31.31.11.00.7-0.70.4-1.51.5-1.41.5-0.30.80.3
Intermittent access day 1 locomotion0.30.40.90.30.50.20.7-0.50.60.7-0.70.6-0.70.70.2-0.9
Intermittent access day 15 total locomotion1.01.83.92.01.91.92.0-1.71.6-0.40.3-0.80.71.00.7-0.7
Intermittent access total locomotion0.70.91.90.90.90.71.4-1.01.20.9-0.90.6-0.61.4-0.1-0.8
Intermittent access standard deviation0.51.12.81.21.11.00.5-0.80.4-1.71.7-1.41.5-0.30.30.3
Left kidney weight2.210.122.84.03.63.94.8-4.24.50.9-1.01.1-0.73.7-0.1-3.1
Right kidney weight2.913.027.04.54.34.65.2-4.85.00.2-0.30.5-0.23.50.9-4.6
Cocaine induced anxiety1.82.64.7-2.0-1.9-1.8-1.21.5-1.12.2-2.11.9-2.00.3-1.00.3
Post-drug Anxiety0.10.10.6-0.1-0.20.00.00.1-0.10.5-0.50.2-0.40.2-0.30.8
Baseline Anxiety2.52.96.32.01.71.80.9-1.30.7-2.52.5-2.22.4-0.40.60.7
Tail length0.31.48.81.01.11.20.9-1.00.9-0.60.6-0.80.9-0.23.00.5
Length with tail1.35.611.53.43.13.33.0-3.22.9-1.21.1-1.31.31.81.8-0.1
Length without tail3.611.527.35.24.34.74.2-4.43.9-2.42.3-2.32.42.8-0.2-0.0
Times rat made contact with spout1.11.23.41.81.31.41.3-1.51.4-0.80.8-0.30.61.00.0-0.6
Lifetime Intake1.11.42.81.31.21.10.7-0.80.4-1.71.7-1.61.6-0.41.10.5
Liver weight, left3.25.311.43.43.43.13.2-3.02.7-1.31.2-1.71.51.6-0.2-0.2
Liver weight, right5.69.819.94.54.14.04.4-4.34.3-0.50.3-0.50.53.5-1.7-1.6
Locomotor activity1.11.73.61.11.30.91.7-1.31.51.1-1.10.8-0.61.6-1.3-1.9
Locomotor testing distance1.52.74.40.91.20.92.0-1.31.72.0-2.01.6-1.52.1-1.5-2.1
Locomotor testing rearing0.71.43.11.01.21.11.8-1.31.51.3-1.30.8-0.81.3-0.5-1.0
Locomotion in novel chamber1.21.64.3-0.10.10.00.9-0.50.91.9-2.02.1-2.01.2-0.1-1.2
Locomotion in novel chamber post-restriction0.61.02.5-1.3-1.6-1.2-1.11.2-1.00.6-0.70.8-0.9-0.61.0-0.8
Fecal boli incidents, locomotor time 10.20.21.90.1-0.2-0.00.10.3-0.4-0.30.4-0.50.5-0.3-0.11.4
Change in fecal boli incidents, locomotor task0.40.41.6-0.9-0.4-0.3-0.70.3-0.30.4-0.3-0.20.1-0.51.1-1.3
Time >=10cm from walls, locomotor time 10.60.71.9-0.8-1.4-1.1-0.81.0-0.90.5-0.50.5-0.5-0.3-0.41.0
Bouts of movement, locomotor time 11.92.24.71.91.41.71.2-0.90.4-2.02.0-2.22.2-0.40.50.4
Total resting periods, locomotor time 11.71.83.81.51.41.70.7-0.90.5-1.92.0-1.91.9-0.30.30.2
Rest time, locomotor task time 10.30.41.40.30.91.00.2-0.70.7-0.20.1-0.20.10.30.0-1.2
Distance moved, locomotor task time 10.10.10.40.2-0.2-0.10.2-0.00.10.2-0.20.4-0.20.30.30.6
Vertical activity count, locomotor time 10.61.43.2-1.0-0.9-1.1-0.10.5-0.21.8-1.71.7-1.60.21.3-1.2
Time >=10cm from walls, locomotor time 20.40.61.51.20.70.91.1-0.80.7-0.30.3-0.80.70.5-0.50.9
Bouts of movement, locomotor time 20.30.41.0-0.8-1.0-0.9-0.51.0-0.90.4-0.30.1-0.1-0.60.40.3
Total resting periods, locomotor time 20.10.20.4-0.4-0.6-0.5-0.30.7-0.70.2-0.1-0.10.1-0.40.40.3
Rest time, locomotor task time 20.20.31.2-0.1-0.0-0.10.2-0.10.20.8-0.91.1-0.90.50.10.1
Distance moved, locomotor task time 20.50.61.50.80.30.40.6-0.1-0.2-1.01.1-1.21.2-0.70.90.3
Vertical activity count, locomotor time 20.30.41.81.10.50.51.3-0.40.3-0.30.3-0.40.30.10.5-0.6
Light reinforcement 10.41.12.3-1.5-1.4-1.4-1.21.4-1.40.8-0.70.1-0.1-0.90.00.7
Light reinforcement 20.91.32.5-1.5-1.6-1.5-1.21.5-1.41.0-0.90.7-0.6-0.70.31.1
Bone: marrow area1.53.26.62.62.52.32.0-2.11.7-1.71.6-1.91.70.9-0.2-0.5
Bone: maximum diameter4.27.816.94.04.13.53.2-3.22.7-2.42.4-2.92.51.50.10.6
Bone: maximum force0.71.33.61.51.91.21.5-1.31.1-0.90.8-0.70.80.7-0.2-0.8
Bone: maximum moment1.01.74.41.82.11.61.6-1.51.3-1.11.1-0.91.10.70.2-0.9
Mean time between licks in bursts0.41.02.30.20.20.2-0.30.1-0.4-1.51.5-1.41.3-1.41.50.1
Mean num. licks in bursts0.91.42.80.60.20.71.1-1.01.31.3-1.41.5-1.61.5-0.3-1.7
Cd content in liver2.02.36.0-1.2-0.4-0.60.20.20.32.4-2.52.4-2.40.6-0.6-1.7
Co content in liver1.21.43.5-1.1-1.3-0.8-0.40.6-0.21.9-1.81.7-1.70.5-1.2-0.7
Cu content in liver0.10.20.4-0.1-0.4-0.20.10.2-0.00.6-0.60.5-0.50.3-0.70.0
Fe content in liver1.01.22.31.20.81.10.6-0.90.5-1.31.4-1.41.5-0.31.50.9
K content in liver0.30.31.1-0.3-1.0-0.6-0.30.7-0.60.5-0.40.3-0.2-0.1-0.11.1
Mg content in liver0.20.22.0-0.0-0.5-0.3-0.10.4-0.50.1-0.0-0.10.1-0.30.31.4
Mn content in liver0.10.10.2-0.4-0.3-0.4-0.20.4-0.30.4-0.40.4-0.3-0.1-0.2-0.2
Na content in liver1.11.22.5-1.3-1.0-1.4-1.41.5-1.6-0.20.2-0.10.2-1.40.61.1
Rb content in liver1.31.53.1-1.0-1.4-1.1-1.41.3-1.5-0.70.7-0.80.8-1.61.31.8
Se content in liver1.01.12.4-1.2-1.4-1.5-1.21.5-1.50.3-0.30.4-0.4-0.90.90.9
Sr content in liver2.01.73.1-1.6-1.4-1.5-0.91.3-1.01.8-1.71.7-1.7-0.4-0.10.1
Zn content in liver0.60.71.7-0.7-1.1-0.7-0.40.6-0.31.2-1.11.3-1.20.2-0.70.1
Bone: minimum diameter2.74.99.83.03.12.92.6-2.62.2-1.81.8-2.21.70.91.3-1.2
Time in familiar zone, hab. session 11.11.13.2-1.1-0.7-0.8-0.20.6-0.21.8-1.81.5-1.60.1-0.2-0.3
Time in novel zone, hab. session 11.41.43.51.31.10.90.5-0.60.2-1.91.9-1.71.8-0.10.80.4
Total zone transitions, hab. session 11.21.73.61.61.61.61.6-1.61.6-0.30.20.20.41.30.9-1.9
Total locomotion distance, hab. session 10.20.32.20.40.50.30.1-0.20.1-0.70.7-0.30.60.01.5-0.2
Locomotion velocity, hab. session 10.20.32.60.30.30.3-0.0-0.10.0-0.70.7-0.20.6-0.01.6-0.4
Time in familiar zone, hab. session 22.72.96.61.72.01.80.9-1.51.0-2.22.2-2.52.6-0.30.60.0
Time in novel zone, hab. session 21.51.54.4-1.1-1.2-1.0-0.30.8-0.31.8-1.82.0-2.10.40.2-0.7
Total zone transitions, hab. session 21.82.24.31.61.92.01.7-2.01.9-0.50.5-0.20.50.91.5-2.1
Total locomotion distance, hab. session 21.01.32.51.41.51.61.2-1.51.4-0.70.6-0.40.60.71.4-1.1
Locomotion velocity, hab. session 20.60.81.41.01.11.20.9-1.21.1-0.50.4-0.10.30.71.0-0.8
Novel to familiar place preference ratio0.10.10.40.0-0.1-0.0-0.30.2-0.3-0.60.6-0.50.5-0.3-0.1-0.3
Novelty place preference0.10.10.40.20.10.1-0.10.0-0.2-0.60.6-0.70.5-0.2-0.1-0.0
Time in novel zone, NPP test0.40.51.40.60.60.50.1-0.30.0-1.11.1-1.21.0-0.30.3-0.2
Total zone transitions, NPP test1.62.34.12.01.92.01.5-1.91.7-1.31.3-0.81.30.90.5-1.5
Total locomotion distance, NPP test1.21.72.61.51.61.61.0-1.51.3-1.51.5-1.01.30.41.2-0.8
Locomotion velocity, NPP test0.50.71.31.01.11.10.7-1.11.0-0.80.8-0.20.60.50.6-0.4
Intraocular pressure2.84.17.22.32.72.61.7-2.21.7-2.32.2-2.22.2-0.01.4-1.4
Delta distance traveled before/after self-admin1.01.02.31.51.31.31.3-1.21.1-0.20.2-0.50.31.1-1.10.2
Delta ambulatory time before/after self-admin1.11.43.21.81.41.51.1-1.20.9-1.11.1-1.31.20.6-0.70.8
Parametrial fat weight7.517.734.15.75.85.64.5-4.94.0-4.03.9-4.34.11.41.3-1.2
Pavlov. Cond. lever latency0.40.41.00.91.00.90.6-0.80.6-0.70.7-0.80.30.30.3-0.3
Pavlov. Cond. magazine entry latency0.30.40.80.90.40.90.5-0.80.7-0.70.6-0.40.70.5-0.1-0.8
Pavlov. Cond. change in total contacts0.20.20.80.0-0.20.10.2-0.10.30.5-0.50.7-0.30.5-0.3-0.9
Pavlov. Cond. index score0.20.20.50.50.10.50.5-0.60.70.2-0.20.40.20.7-0.6-0.6
Pavlov. Cond. latency score0.10.20.40.30.00.40.4-0.40.50.3-0.30.40.10.6-0.5-0.4
Pavlov. Cond. lever contacts0.40.51.0-1.0-1.0-0.9-0.80.9-0.80.5-0.50.6-0.2-0.5-0.40.3
Pavlov. Cond. magazine entry number1.01.22.4-1.4-1.0-1.5-1.31.5-1.50.3-0.2-0.1-0.4-1.20.51.5
Pavlov. Cond. intertrial magazine entries0.20.31.80.30.60.50.4-0.40.3-0.30.3-0.30.3-0.21.3-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.40.00.40.3-0.50.50.1-0.10.30.30.6-0.7-0.4
Pavlov. Cond. response bias0.10.10.50.0-0.20.20.1-0.20.20.2-0.20.40.10.3-0.3-0.7
Pavlov. Cond. lever latency1.62.16.0-0.2-0.3-0.00.7-0.51.02.4-2.42.2-1.91.7-1.4-0.9
Pavlov. Cond. magazine entry latency1.51.83.31.81.31.61.1-1.20.9-1.81.8-1.61.60.10.30.2
Pavlov. Cond. change in total contacts1.93.07.80.70.80.7-0.3-0.1-0.4-2.82.8-2.52.3-1.72.70.7
Pavlov. Cond. index score1.82.47.11.21.11.00.2-0.5-0.0-2.72.7-2.32.1-1.11.40.5
Pavlov. Cond. latency score1.72.36.81.41.11.10.4-0.60.1-2.62.6-2.32.1-0.81.00.4
Pavlov. Cond. lever contacts1.11.54.40.30.40.2-0.40.2-0.6-2.12.1-1.81.5-1.41.50.4
Pavlov. Cond. magazine entry number1.41.74.4-1.6-1.2-1.4-0.81.1-0.72.1-2.11.7-1.60.1-0.50.2
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.10.5-0.10.40.00.00.6-0.60.1-0.10.3-0.20.2
Pavlov. Cond. lever-magazine prob. diff.1.52.06.21.21.11.00.3-0.50.1-2.52.5-2.11.8-0.91.10.5
Pavlov. Cond. response bias1.62.16.40.80.80.7-0.1-0.2-0.3-2.52.5-2.21.9-1.31.70.4
Time in closed arm before self-admin0.30.42.8-0.6-0.2-0.3-0.20.3-0.20.5-0.50.3-0.4-0.61.7-0.1
Time in closed arm after self-admin0.70.71.9-1.3-0.6-0.7-0.50.5-0.31.0-1.00.9-1.0-0.30.7-1.4
Time in open arm before self-admin1.01.14.4-0.9-1.4-1.4-1.21.2-1.10.2-0.20.4-0.20.0-2.11.1
Time in open arm after self-admin1.01.15.20.80.00.1-0.20.2-0.5-1.21.2-1.41.3-0.3-1.02.3
Bone: periosteal estimation3.77.716.54.04.13.63.4-3.42.9-2.22.1-2.52.11.60.6-0.9
Bone: periosteal perimeter5.08.619.94.24.53.73.7-3.63.1-2.22.1-2.42.11.9-0.1-0.7
Bone: post-yield work0.81.22.6-0.30.3-0.3-0.90.5-0.8-1.61.6-1.51.6-1.3-1.21.0
Progressive ratio test 1 active lever presses1.21.53.21.01.21.00.6-0.70.3-1.61.6-1.81.6-0.81.8-0.2
Progressive ratio test 1 breakpoint1.21.43.50.91.10.90.5-0.70.2-1.61.6-1.81.6-0.91.9-0.2
Progressive ratio test 1 inactive lever presses1.52.25.91.20.91.20.1-0.5-0.0-2.42.4-2.32.3-1.10.90.9
Progressive ratio test 2 active lever presses2.12.54.12.01.72.01.3-1.41.0-1.91.9-1.91.9-0.21.3-0.6
Progressive ratio test 2 breakpoint2.32.64.52.11.72.11.4-1.51.1-1.91.9-1.91.8-0.01.3-0.6
Progressive ratio test 2 inactive lever presses1.22.03.91.61.41.70.9-0.90.5-1.91.9-2.02.0-0.51.00.5
Incentive Sensitization - Responses1.21.63.31.81.31.71.0-1.20.9-1.81.7-1.51.50.2-0.1-0.4
Incentive Sensitization - Breakpoint1.11.53.11.81.21.60.9-1.10.8-1.71.6-1.41.50.3-0.2-0.3
Sum of active levers in priming session hrs 5-60.70.72.5-0.6-1.0-0.8-1.00.9-1.0-0.40.4-0.40.4-0.4-0.81.6
Progressive ratio0.50.71.9-1.2-0.8-1.2-1.41.1-1.2-0.30.30.00.2-1.00.40.5
Food seeking constrained by brief footshock1.31.63.7-0.4-0.4-0.4-1.20.9-1.3-1.91.9-1.51.8-1.80.90.4
Seeking ratio, punishment vs. effort0.30.41.01.00.70.90.8-0.70.6-0.60.6-0.70.70.20.0-0.3
Retroperitoneal fat weight8.034.168.28.38.08.16.8-7.16.0-4.94.7-5.35.12.80.9-1.7
Reaction time number correct0.91.73.71.91.51.61.1-1.41.1-1.61.5-1.51.50.60.0-0.1
Reaction time mean minus median0.10.31.00.70.70.50.5-0.40.4-0.30.3-0.30.20.4-1.00.2
Reaction time mean minus median AUC0.20.61.60.80.90.71.0-0.80.90.3-0.40.3-0.41.0-1.3-0.5
Reaction time num false alarms0.10.10.30.2-0.00.2-0.1-0.0-0.1-0.50.5-0.50.5-0.2-0.3-0.2
Reaction time num false alarms AUC0.00.00.20.2-0.10.20.0-0.00.0-0.20.2-0.20.20.0-0.3-0.5
Reaction time trials correct on left0.91.73.71.91.51.61.1-1.41.1-1.61.5-1.51.50.60.0-0.1
Reaction time trials on left1.01.83.92.01.61.71.2-1.41.1-1.61.6-1.51.50.60.1-0.2
Reaction time mean0.40.71.7-0.10.0-0.10.4-0.00.31.1-1.11.3-1.30.9-1.3-0.4
Reaction time mean AUC0.40.61.7-0.5-0.4-0.6-0.00.4-0.11.2-1.11.2-1.30.5-1.1-0.2
Median of all reaction times0.81.13.0-0.3-0.2-0.40.30.10.31.5-1.51.7-1.71.0-1.4-0.5
Reaction time omissions0.10.20.60.20.70.40.3-0.20.1-0.50.5-0.50.2-0.30.5-0.4
Reaction time false alarm rate0.20.30.8-0.9-0.8-0.7-0.70.7-0.70.4-0.30.3-0.3-0.60.1-0.1
Reaction time premature initiation rate1.11.53.90.90.40.81.3-1.11.41.3-1.31.3-1.02.0-1.4-0.5
Reaction time premature initiations1.42.56.12.11.41.82.0-2.02.10.4-0.50.6-0.22.5-1.6-0.9
Std. dev. reaction times0.40.71.61.21.31.11.2-1.01.0-0.20.1-0.10.00.9-0.8-0.5
Reaction time trials completed1.01.83.92.01.61.71.2-1.41.1-1.61.6-1.51.50.60.1-0.2
Reaction time trials AUC1.01.94.12.01.61.71.2-1.51.1-1.71.6-1.61.60.60.2-0.3
Run reversals in cocaine runway, females1.01.02.01.21.11.01.4-1.21.30.5-0.50.8-0.81.3-0.6-0.2
Run reversals in cocaine runway, males0.90.91.8-1.3-1.0-1.2-1.21.3-1.30.3-0.2-0.10.0-1.0-0.11.0
Latency to leave start box in cocaine runway0.60.71.4-1.1-1.2-1.1-0.91.0-0.90.7-0.70.4-0.7-0.4-0.01.0
Latency to leave start box in cocaine runway, F0.91.02.0-1.4-1.3-1.3-0.91.1-0.91.2-1.20.8-1.1-0.20.10.2
Latency to leave start box in cocaine runway, M0.10.10.40.30.20.30.1-0.10.0-0.50.5-0.50.5-0.2-0.00.6
Std. dev. time between licks in bursts1.41.93.9-0.1-0.1-0.3-0.90.7-1.1-1.92.0-1.91.9-1.81.31.5
Total sessions with >9 infusions1.61.93.51.81.91.91.6-1.61.3-1.21.2-1.01.20.31.3-0.7
Short access day 1 total inactive lever presses1.11.43.01.71.11.41.0-1.00.7-1.21.1-1.51.50.4-0.31.3
Short access day 10 total inactive lever presses0.30.71.21.11.01.10.8-1.00.9-0.60.5-0.40.40.5-1.1-0.4
Short access day 1 total infusions0.30.40.91.00.80.90.7-0.70.5-0.60.6-0.80.60.30.40.4
Short access day 10 total infusions0.40.61.4-0.1-0.0-0.2-0.60.3-0.5-1.11.1-0.80.8-1.01.20.3
Short access total infusions0.50.71.60.80.80.60.3-0.50.2-1.31.3-1.01.1-0.40.90.3
Short access day 1 locomotion0.40.51.30.90.80.90.5-0.40.2-0.90.9-1.21.0-0.10.20.7
Short access day 10 total locomotion1.12.14.20.81.10.91.7-1.31.61.7-1.71.4-1.52.0-1.0-1.3
Short access total locomotion0.70.91.80.81.11.01.3-1.11.20.6-0.60.6-0.41.10.1-1.3
One hour access (0.3 mA shock)3.54.010.61.61.21.00.0-0.4-0.3-3.33.3-3.23.2-1.10.31.8
Compulsive drug intake1.21.45.90.70.20.2-0.40.2-0.6-1.61.6-1.51.9-0.5-0.72.4
One hour access (shock baseline)0.30.50.90.80.90.70.7-0.70.5-0.60.6-0.80.7-0.00.9-0.5
Social response proportion2.83.16.72.01.71.82.3-2.02.30.5-0.61.1-0.92.2-1.4-2.6
Social responses3.14.08.42.92.42.82.3-2.42.0-1.71.7-1.82.00.9-0.0-1.3
Social time1.11.53.21.61.01.71.8-1.61.60.3-0.40.1-0.21.6-1.0-0.8
Soleus weight3.39.819.34.33.53.94.3-4.34.40.1-0.30.20.44.2-2.1-2.0
Bone: stiffness0.10.10.80.30.9-0.10.5-0.10.1-0.20.2-0.20.10.00.0-0.6
Tibialis anterior weight0.20.62.20.1-0.40.1-0.70.2-0.5-1.31.3-0.91.5-0.80.6-0.1
Time to tail flick, vehicle, before self-admin0.40.41.01.00.70.70.8-0.70.7-0.10.00.10.20.9-1.00.3
Time to tail flick, vehicle, after self-admin0.40.54.10.1-0.6-0.6-0.40.5-0.5-0.40.40.10.2-0.2-1.02.0
Time to tail flick, test, before self-admin1.21.23.20.20.20.20.8-0.50.81.4-1.41.4-1.41.3-0.9-1.8
Time to tail flick, test, after self-admin0.50.61.20.90.80.60.4-0.40.2-1.11.1-1.01.0-0.2-0.11.0
Delta time to tail flick, vehicle, before/after SA0.80.72.1-0.2-0.4-0.4-0.70.6-0.8-1.01.0-0.90.9-1.11.01.4
Delta time to tail flick, test, before/after SA0.40.51.40.40.40.2-0.0-0.1-0.1-1.01.0-0.91.0-0.60.21.2
Tibia length1.13.17.42.12.32.02.7-2.22.40.7-0.80.6-0.52.3-0.4-0.9
Ambulatory time before self-admin1.92.96.6-0.20.20.21.2-0.61.12.5-2.62.4-2.51.7-0.5-2.5
Ambulatory time after self-admin2.52.96.61.10.80.81.9-1.21.62.1-2.11.7-2.02.6-2.3-0.8
Bone: tissue strength0.40.41.9-0.7-0.5-0.4-0.70.6-0.7-0.20.2-0.10.5-1.11.40.1
Total heroin consumption2.22.54.41.92.02.11.5-1.61.2-1.81.7-1.71.7-0.11.6-0.6
Bone: trabecular number0.61.02.21.30.70.90.6-0.50.2-1.51.5-1.41.4-0.21.10.0
Bone: trabecular spacing0.20.20.5-0.7-0.6-0.5-0.70.6-0.60.1-0.1-0.0-0.2-0.60.20.1
Bone: trabecular thickness3.94.811.33.42.82.82.5-2.62.2-1.91.8-2.21.91.6-0.30.5
Bone: trabecular tissue density0.40.61.7-0.80.0-0.8-0.10.4-0.11.2-1.20.9-1.30.5-1.20.2
Water consumed over 24 hours0.60.81.61.21.00.71.3-1.01.10.3-0.30.6-0.41.10.3-1.2
Number of responses in last shaping day0.30.42.30.00.20.4-0.0-0.20.1-0.60.6-0.40.3-0.51.5-1.0