Hub : Genes

Acsl5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Acsl5 0.05 0.04 1.3e-04 0.03 0.02 0.03 0.02 5.2e-04 1.6e-03 3.6e-04 1.4e-03
2 NAcc gene expression Acsl5 0.06 0.04 1.0e-06 0.04 0.05 0.04 0.04 5.2e-06 4.0e-06 3.4e-05 1.8e-05
3 PL gene expression Acsl5 0.02 0.02 3.7e-03 0 0.01 0.01 -0 2.3e-01 1.1e-02 3.4e-02 4.4e-01
4 OFC gene expression Acsl5 0.26 0.15 3.6e-05 0.15 0.17 0.16 0.16 1.8e-04 6.0e-05 1.1e-04 1.6e-04
5 Liver mRNA stability Acsl5 0.08 0.05 1.6e-09 0.07 0.07 0.07 0.06 6.2e-08 1.9e-08 2.9e-08 2.2e-07
6 Adipose gene expression Acsl5 0.02 0.02 3.1e-03 0.01 0.02 0.01 0 7.0e-03 5.4e-03 2.8e-02 8.0e-02
7 PL mRNA stability Acsl5 0.04 0.03 3.8e-03 0.02 0.02 0.01 0.02 1.1e-03 2.5e-03 1.2e-02 5.4e-03
8 PL intron excision ratio chr1_254294502_254310070 0.04 0.04 2.4e-03 0.02 0.02 0.01 0.02 4.1e-03 3.1e-03 8.7e-03 5.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.52.54.8-2.22.1-1.5-1.41.01.01.81.3
Area under the delay curve0.80.91.9-1.21.2-0.6-0.50.20.21.41.3
BMI with tail7.624.735.7-6.05.8-5.8-5.85.45.41.7-0.4
BMI without tail3.36.811.5-3.43.2-2.9-2.92.52.51.70.5
Body weight9.338.954.8-7.37.1-7.4-7.36.96.91.8-0.6
Weight adjusted by age4.95.57.8-2.62.4-2.8-2.82.82.8-0.0-1.0
Bone surface0.61.02.5-1.61.2-1.0-1.00.80.80.80.4
Bone volume2.64.48.2-2.92.6-2.3-2.21.91.91.50.7
Breakpoint value in progressive ratio session1.01.13.7-1.11.0-0.1-0.1-0.3-0.31.91.7
Number of licking bursts0.80.92.4-1.41.1-0.4-0.3-0.0-0.01.51.4
Context. condit. distance diff. score0.60.72.20.8-1.00.40.3-0.1-0.0-1.5-1.3
Locomotion velocity, session 12.22.43.91.2-1.31.81.9-2.0-2.00.41.1
Locomotion distance, session 10.40.51.00.9-0.90.60.6-0.4-0.4-1.0-0.7
Locomotion velocity, session 21.21.44.11.4-1.40.60.5-0.1-0.1-2.0-1.7
Locomotion distance, session 21.21.72.4-1.41.5-1.6-1.61.51.50.3-0.2
Locomotion velocity, session 30.20.20.70.2-0.3-0.0-0.10.20.2-0.8-0.8
Locomotion distance, session 30.90.92.90.2-0.2-0.5-0.60.90.9-1.6-1.7
Stereotopy head waving bouts, day 30.10.10.2-0.30.4-0.3-0.30.20.20.30.2
Stereotopy head waving duration, day 30.91.01.70.6-0.81.21.2-1.3-1.30.50.9
Locomotion velocity, session 70.00.00.1-0.30.2-0.1-0.10.00.00.20.2
Locomotion distance, session 70.10.20.60.3-0.40.00.00.10.1-0.8-0.7
Stereotopy head waving bouts, day 70.10.10.2-0.50.2-0.00.0-0.1-0.10.40.4
Stereotopy head waving duration, day 70.40.41.2-1.10.8-0.4-0.40.20.20.90.7
Locomotion velocity, session 81.31.52.61.6-1.61.31.3-1.0-1.0-1.1-0.5
Locomotion distance, session 80.40.51.90.6-0.70.10.10.20.2-1.4-1.2
Degree of sensitization distance1.21.22.10.3-0.51.11.1-1.3-1.31.11.4
Degree of sensitization stereotypy0.20.20.6-0.60.4-0.1-0.1-0.0-0.00.70.6
Conditioned locomotion0.10.10.20.4-0.30.10.00.00.0-0.4-0.3
Cocaine response after cond. corrected1.11.22.31.5-1.41.01.0-0.7-0.7-1.2-1.0
Cocaine response after cond. not corrected2.02.24.02.0-1.91.61.5-1.2-1.2-1.2-0.7
Cocaine response before conditioning0.70.81.30.7-0.61.01.0-1.1-1.20.51.0
Saline control response0.40.51.01.0-0.90.60.6-0.4-0.4-0.9-0.6
Bone: connectivity density0.00.10.10.1-0.20.30.3-0.4-0.40.10.3
Bone: cortical apparent density2.53.39.82.0-2.00.70.60.10.1-3.1-2.8
Bone: cortical area6.59.720.9-4.63.9-3.3-3.22.72.72.41.1
Bone: cortical porosity0.40.51.4-0.60.50.00.1-0.3-0.31.21.2
Bone: cortical porosity0.80.82.5-0.91.0-0.3-0.3-0.1-0.11.61.4
Bone: cortical thickness3.25.29.6-3.12.6-2.6-2.52.32.31.00.0
Bone: cortical thickness1.72.02.8-1.61.4-1.7-1.71.71.7-0.1-0.6
Bone: cortical tissue density2.73.610.22.2-2.20.80.7-0.0-0.0-3.2-2.8
Condit. Reinf. active minus inactive responses0.30.30.50.2-0.30.70.7-0.7-0.70.30.4
Condit. Reinf. active-inactive response ratio0.60.61.10.5-0.71.01.0-1.0-1.00.10.3
Condit. Reinf. active responses0.30.31.1-0.70.7-0.1-0.1-0.1-0.11.10.8
Condit. Reinf. inactive responses0.70.81.9-1.11.2-0.6-0.50.20.21.41.1
Incentive salience index mean0.81.01.60.8-0.81.21.2-1.2-1.20.20.5
Condit. Reinf. lever presses0.81.11.70.9-0.91.21.2-1.3-1.30.30.7
Condit. Reinf. active minus inactive responses2.63.27.5-1.10.41.11.2-1.8-1.82.72.7
Condit. Reinf. active-inactive response ratio2.12.23.7-0.5-0.31.41.5-1.8-1.81.81.9
Condit. Reinf. active responses2.33.29.7-1.81.20.30.5-1.1-1.13.12.9
Condit. Reinf. inactive responses0.70.92.4-1.11.1-0.5-0.40.10.11.51.3
Condit. Reinf. lever presses1.31.85.1-1.20.60.50.6-1.0-1.02.32.2
Condit. Reinf. lever reinforcers received2.13.08.9-1.61.00.50.6-1.2-1.23.02.8
Conditioned reinforcement - actives0.20.20.30.4-0.40.50.5-0.5-0.5-0.00.1
Conditioned reinforcement - inactives0.50.61.3-1.01.0-0.6-0.50.30.31.10.9
Conditioned locomotion0.20.30.60.8-0.60.50.6-0.5-0.5-0.30.1
Patch foraging indifference point 0 sec2.74.37.1-2.72.6-2.4-2.32.12.11.20.4
Patch foraging indifference point AUC1.31.44.4-1.01.3-0.4-0.3-0.2-0.22.12.1
Delay disc. indifference point, 0s delay0.91.01.5-1.21.2-1.1-1.11.00.90.60.3
Delay disc. indifference point, 16s delay0.60.62.0-0.30.30.30.3-0.6-0.61.21.4
Delay disc. indifference point, 2s delay0.10.10.1-0.20.3-0.4-0.40.30.3-0.0-0.0
Delay disc. indifference point, 24s delay1.51.44.5-1.21.2-0.2-0.1-0.3-0.32.02.1
Delay disc. indifference point, 4s delay0.20.20.7-0.20.20.20.2-0.4-0.40.80.8
Delay disc. indifference point, 8s delay2.42.54.5-2.12.1-1.4-1.30.90.91.81.5
Indifference point function ln k0.40.61.80.6-0.90.30.20.00.1-1.3-1.3
Indifference point function log k0.40.61.80.6-0.90.30.20.00.1-1.3-1.3
Patch foraging total patch changes 0 sec2.74.37.2-2.72.6-2.3-2.21.91.91.50.7
Patch foraging total patch changes 12 sec1.21.63.1-1.61.7-0.9-0.90.50.51.81.6
Patch foraging total patch changes 18 sec3.24.07.4-2.52.7-1.6-1.50.80.82.72.3
Patch foraging total patch changes 24 sec2.83.510.2-1.92.2-0.8-0.70.00.03.22.8
Patch foraging total patch changes 6 sec3.75.510.1-3.23.1-2.4-2.41.91.92.11.3
Patch foraging time to switch 0 sec0.61.01.71.2-1.31.01.0-0.8-0.8-1.0-0.7
Patch foraging water rate 0 sec0.60.91.4-1.11.2-1.1-1.11.01.00.50.2
Patch foraging water rate 12 sec0.91.32.2-1.51.5-1.2-1.20.90.91.10.6
Patch foraging water rate 18 sec0.71.01.4-1.11.0-1.2-1.21.21.2-0.2-0.5
Patch foraging water rate 24 sec2.12.95.1-2.32.0-1.9-1.91.71.70.90.1
Patch foraging water rate 6 sec0.50.81.1-0.60.4-0.9-0.91.11.1-0.9-0.9
Seeking ratio, delayed vs. immediate footshock0.00.00.00.2-0.20.10.2-0.1-0.2-0.00.1
Distance traveled before self-admin1.71.95.91.1-1.0-0.1-0.20.70.7-2.4-2.4
Distance traveled after self-admin2.22.55.1-0.10.2-1.3-1.41.81.8-2.2-2.2
Extensor digitorum longus weight0.52.03.4-1.71.8-1.6-1.51.31.31.10.6
Bone: elastic displacement0.10.10.3-0.30.30.00.0-0.1-0.10.50.5
Bone: elastic work1.31.62.6-1.11.0-1.5-1.51.61.6-0.5-1.0
Bone: endosteal estimation1.73.77.1-2.72.4-2.0-1.91.61.61.70.9
Bone: endosteal perimeter2.75.512.5-3.52.8-2.5-2.42.12.11.60.6
Epididymis fat weight12.629.246.9-6.86.7-6.1-6.05.35.33.31.1
Delta time in closed arm before/after self-admin0.40.41.40.3-0.3-0.2-0.20.40.5-1.1-1.2
Delta time in open arm before/after self-admin1.21.13.5-1.11.1-0.3-0.2-0.1-0.11.91.7
Diff in mean of infusions in LGA sessions2.12.33.51.4-1.61.91.9-1.8-1.80.20.4
Delay discount exponential model param1.01.02.31.3-1.30.60.6-0.2-0.2-1.5-1.4
Extinction: sum of active levers before priming0.60.62.2-0.20.20.50.5-0.8-0.81.01.5
Active lever presses in extinction session 60.40.40.7-0.80.8-0.6-0.50.40.40.80.7
Bone: final force1.72.76.2-2.51.9-1.8-1.71.51.50.90.3
Bone: final moment2.23.67.8-2.82.3-2.1-2.01.81.81.10.4
Food consumed during 24 hour testing period0.10.10.4-0.1-0.1-0.1-0.10.20.2-0.5-0.6
Glucose3.45.17.5-2.22.2-2.7-2.72.72.7-0.1-1.0
Heart weight1.62.34.2-2.01.7-1.7-1.71.61.60.2-0.4
Delay discount hyperbolic model param0.60.71.41.0-1.10.60.5-0.3-0.3-1.2-1.0
Intermittent access intake day 1-15 change2.02.03.8-1.91.8-1.4-1.31.01.01.40.9
Intermittent access intake escalation2.82.84.7-2.22.0-1.9-1.91.71.70.80.2
Intermittent access intake escalation 21.61.62.5-1.61.5-1.5-1.51.31.30.60.1
Intermitt. access day 1 inactive lever presses1.81.93.6-1.81.8-1.1-1.10.70.71.91.4
Intermitt. access day 15 inactive lever presses0.20.20.8-0.40.30.10.1-0.3-0.20.90.6
Intermitt. access escalation Index0.20.20.3-0.20.1-0.5-0.40.50.5-0.5-0.5
Intermittent access day 1 total infusions0.60.72.4-0.60.60.20.2-0.5-0.61.41.5
Intermittent access day 15 total infusions1.51.63.2-1.81.7-1.0-0.90.50.51.71.4
Intermittent access terminal intake (last 3 days)0.80.92.1-1.21.1-0.5-0.40.10.11.41.3
Intermittent access total infusions0.91.02.6-1.21.2-0.5-0.40.00.01.61.5
Intermittent access day 1 locomotion0.10.10.20.2-0.20.00.00.10.1-0.4-0.4
Intermittent access day 15 total locomotion1.41.62.8-1.71.6-1.3-1.31.01.01.10.7
Intermittent access total locomotion0.10.10.2-0.10.1-0.4-0.40.50.5-0.4-0.4
Intermittent access standard deviation2.02.25.1-1.71.8-0.7-0.60.10.12.32.2
Left kidney weight4.512.620.0-2.82.6-4.1-4.14.54.5-1.9-3.0
Right kidney weight4.713.120.0-3.53.2-4.3-4.34.54.5-0.9-2.3
Cocaine induced anxiety3.33.87.12.7-2.61.51.5-0.9-0.9-2.5-2.0
Post-drug Anxiety0.50.51.20.8-0.90.30.3-0.1-0.0-1.1-1.0
Baseline Anxiety5.55.911.0-3.33.2-2.3-2.21.61.62.51.9
Tail length0.30.81.6-1.21.2-0.7-0.70.40.41.30.8
Length with tail2.27.911.2-3.33.2-3.3-3.33.13.10.8-0.2
Length without tail5.311.516.8-3.63.5-4.1-4.14.04.00.0-1.0
Times rat made contact with spout1.21.42.1-1.21.4-1.4-1.41.31.30.3-0.1
Lifetime Intake1.11.23.1-1.41.3-0.5-0.40.00.01.81.7
Liver weight, left3.35.39.2-2.93.0-2.3-2.21.71.62.51.7
Liver weight, right7.111.916.8-4.04.1-4.1-4.03.73.71.40.2
Locomotor activity1.01.62.5-1.00.8-1.4-1.41.61.6-0.8-1.3
Locomotor testing distance1.72.94.6-0.90.7-1.7-1.82.12.1-1.5-2.1
Locomotor testing rearing0.81.32.1-0.90.8-1.3-1.31.41.4-0.5-1.1
Locomotion in novel chamber0.91.13.20.2-0.2-0.6-0.71.01.0-1.7-1.8
Locomotion in novel chamber post-restriction0.81.02.01.4-1.30.90.9-0.7-0.7-0.9-0.8
Fecal boli incidents, locomotor time 10.10.10.4-0.10.10.20.2-0.3-0.30.50.6
Change in fecal boli incidents, locomotor task0.10.10.10.4-0.30.30.3-0.3-0.30.0-0.2
Time >=10cm from walls, locomotor time 10.70.81.61.3-1.00.90.9-0.8-0.8-0.5-0.2
Bouts of movement, locomotor time 11.92.04.9-1.81.7-0.8-0.70.30.22.22.0
Total resting periods, locomotor time 11.71.94.2-1.81.7-0.8-0.80.30.32.01.8
Rest time, locomotor task time 10.30.30.4-0.60.6-0.6-0.60.60.60.2-0.2
Distance moved, locomotor task time 10.00.10.20.10.1-0.2-0.20.20.2-0.5-0.2
Vertical activity count, locomotor time 11.11.23.41.2-1.20.40.30.10.1-1.8-1.7
Time >=10cm from walls, locomotor time 20.50.50.9-0.81.0-0.7-0.70.50.50.90.5
Bouts of movement, locomotor time 20.80.91.31.0-1.11.11.1-1.1-1.1-0.20.1
Total resting periods, locomotor time 20.40.50.70.6-0.70.80.8-0.8-0.80.00.3
Rest time, locomotor task time 20.20.20.80.3-0.3-0.1-0.10.30.3-0.9-0.8
Distance moved, locomotor task time 20.50.51.8-0.70.8-0.1-0.1-0.2-0.21.31.2
Vertical activity count, locomotor time 20.20.20.4-0.60.6-0.5-0.50.40.40.40.2
Light reinforcement 10.81.42.11.2-1.31.41.5-1.4-1.4-0.20.3
Light reinforcement 21.21.62.51.5-1.61.51.5-1.3-1.3-0.8-0.1
Bone: marrow area1.83.87.3-2.72.5-2.0-2.01.61.61.70.9
Bone: maximum diameter5.610.221.5-4.64.0-3.3-3.22.62.62.81.6
Bone: maximum force1.32.25.4-2.31.7-1.6-1.61.41.40.70.1
Bone: maximum moment1.83.06.7-2.62.0-1.9-1.81.61.70.90.2
Mean time between licks in bursts0.30.41.3-0.50.50.20.2-0.5-0.51.21.1
Mean num. licks in bursts1.21.43.10.30.1-1.0-1.01.31.3-1.5-1.8
Cd content in liver2.32.53.81.4-1.61.92.0-1.9-1.90.10.6
Co content in liver0.50.61.71.1-0.6-0.0-0.10.40.4-1.3-1.2
Cu content in liver0.20.30.5-0.10.3-0.6-0.60.70.7-0.5-0.6
Fe content in liver0.10.10.2-0.10.5-0.4-0.40.30.30.30.1
K content in liver0.10.10.40.7-0.20.30.3-0.3-0.40.20.4
Mg content in liver0.50.51.7-0.30.40.10.2-0.4-0.41.21.3
Mn content in liver0.30.40.70.8-0.80.50.5-0.4-0.4-0.7-0.5
Na content in liver1.41.52.50.6-0.81.41.4-1.6-1.60.81.2
Rb content in liver1.31.62.40.9-0.61.31.3-1.5-1.51.11.5
Se content in liver0.91.11.60.9-1.11.21.3-1.2-1.2-0.10.4
Sr content in liver1.81.62.91.6-1.71.31.2-0.9-0.9-1.4-0.9
Zn content in liver2.02.24.42.1-1.91.31.2-0.9-0.9-1.8-1.2
Bone: minimum diameter3.36.112.2-3.53.1-2.6-2.52.12.12.00.9
Time in familiar zone, hab. session 11.00.92.41.0-1.10.50.4-0.1-0.1-1.5-1.4
Time in novel zone, hab. session 11.41.33.4-1.51.3-0.5-0.50.10.11.91.6
Total zone transitions, hab. session 11.21.72.5-1.31.3-1.6-1.61.61.60.0-0.5
Total locomotion distance, hab. session 10.10.10.3-0.50.4-0.2-0.20.00.00.50.5
Locomotion velocity, hab. session 10.00.10.2-0.30.3-0.1-0.1-0.0-0.00.40.4
Time in familiar zone, hab. session 23.03.05.9-2.32.3-1.4-1.30.80.82.41.7
Time in novel zone, hab. session 21.51.53.91.5-1.50.70.6-0.2-0.2-2.0-1.6
Total zone transitions, hab. session 22.02.53.6-1.71.8-1.9-1.91.81.80.4-0.4
Total locomotion distance, hab. session 21.21.52.2-1.31.4-1.5-1.51.41.40.4-0.1
Locomotion velocity, hab. session 20.60.91.3-1.01.1-1.1-1.11.11.10.2-0.2
Novel to familiar place preference ratio0.20.20.5-0.10.10.20.2-0.4-0.40.70.7
Novelty place preference0.20.20.6-0.30.30.10.1-0.3-0.30.80.8
Time in novel zone, NPP test0.50.61.7-0.80.8-0.2-0.2-0.1-0.11.31.2
Total zone transitions, NPP test1.82.54.0-1.92.0-1.8-1.81.61.61.00.3
Total locomotion distance, NPP test1.31.83.1-1.71.8-1.5-1.41.21.21.10.5
Locomotion velocity, NPP test0.60.81.2-1.01.1-1.1-1.11.01.00.3-0.0
Intraocular pressure3.44.79.0-3.02.9-2.0-2.01.41.42.51.5
Delta distance traveled before/after self-admin1.61.82.6-1.61.5-1.6-1.61.51.50.2-0.1
Delta ambulatory time before/after self-admin1.61.83.2-1.81.7-1.4-1.31.11.11.10.9
Parametrial fat weight6.913.423.1-4.74.8-3.9-3.83.13.03.31.9
Pavlov. Cond. lever latency0.50.71.2-1.01.1-0.8-0.80.60.60.90.6
Pavlov. Cond. magazine entry latency0.40.50.8-0.60.9-0.8-0.90.80.80.40.1
Pavlov. Cond. change in total contacts0.10.20.40.3-0.2-0.2-0.20.30.3-0.7-0.6
Pavlov. Cond. index score0.20.30.5-0.10.4-0.6-0.60.70.7-0.3-0.4
Pavlov. Cond. latency score0.10.20.30.00.2-0.5-0.50.50.5-0.3-0.4
Pavlov. Cond. lever contacts0.30.40.60.8-0.80.70.7-0.7-0.6-0.3-0.1
Pavlov. Cond. magazine entry number1.11.42.20.8-1.21.41.5-1.5-1.50.00.5
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.60.4-0.4-0.40.30.30.2-0.0
Pavlov. Cond. lever-magazine prob. diff.0.10.20.3-0.10.4-0.5-0.50.50.5-0.1-0.2
Pavlov. Cond. response bias0.10.20.30.00.2-0.4-0.40.50.5-0.3-0.4
Pavlov. Cond. lever latency2.12.88.21.1-0.8-0.6-0.81.31.3-2.8-2.9
Pavlov. Cond. magazine entry latency1.41.72.9-1.61.7-1.1-1.10.80.81.71.2
Pavlov. Cond. change in total contacts1.72.47.6-1.61.4-0.1-0.0-0.5-0.52.82.5
Pavlov. Cond. index score1.72.26.4-1.81.6-0.5-0.4-0.1-0.12.52.2
Pavlov. Cond. latency score1.72.16.2-1.81.6-0.5-0.4-0.1-0.12.52.2
Pavlov. Cond. lever contacts1.01.44.5-1.20.90.10.2-0.6-0.62.12.0
Pavlov. Cond. magazine entry number1.31.52.91.6-1.61.01.0-0.6-0.6-1.7-1.3
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.3-0.10.10.1-0.1-0.1-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.1.51.95.4-1.71.5-0.5-0.4-0.1-0.12.32.0
Pavlov. Cond. response bias1.31.85.5-1.61.4-0.3-0.2-0.2-0.22.42.1
Time in closed arm before self-admin0.10.10.2-0.20.2-0.4-0.40.40.50.0-0.5
Time in closed arm after self-admin0.20.20.60.6-0.60.40.3-0.2-0.2-0.5-0.8
Time in open arm before self-admin1.41.52.41.6-1.41.41.4-1.3-1.3-0.60.0
Time in open arm after self-admin1.21.43.90.1-0.00.80.9-1.2-1.31.52.0
Bone: periosteal estimation5.010.420.4-4.54.0-3.5-3.42.92.92.41.0
Bone: periosteal perimeter6.811.423.4-4.84.1-3.7-3.53.13.12.30.9
Bone: post-yield work0.50.61.6-0.60.30.40.5-0.7-0.71.21.3
Progressive ratio test 1 active lever presses0.50.51.1-1.00.9-0.5-0.40.20.20.90.8
Progressive ratio test 1 breakpoint0.30.41.0-0.60.50.00.1-0.3-0.31.01.0
Progressive ratio test 1 inactive lever presses0.50.62.1-0.70.7-0.0-0.0-0.3-0.31.41.3
Progressive ratio test 2 active lever presses1.41.53.2-1.81.6-1.1-1.00.70.71.41.0
Progressive ratio test 2 breakpoint1.41.63.1-1.81.6-1.0-0.90.60.61.71.2
Progressive ratio test 2 inactive lever presses1.11.23.6-1.41.2-0.5-0.40.00.01.91.5
Incentive Sensitization - Responses0.90.91.9-1.41.2-0.7-0.60.30.31.41.1
Incentive Sensitization - Breakpoint1.01.02.1-1.41.2-0.7-0.60.30.31.41.1
Sum of active levers in priming session hrs 5-61.41.41.91.4-1.31.41.4-1.4-1.4-0.10.4
Progressive ratio1.01.21.90.8-0.91.31.3-1.4-1.40.60.8
Food seeking constrained by brief footshock1.11.43.1-0.0-0.01.01.0-1.3-1.31.61.8
Seeking ratio, punishment vs. effort0.20.30.5-0.70.7-0.6-0.60.50.50.30.2
Retroperitoneal fat weight11.437.354.4-7.47.3-7.1-7.16.56.52.60.2
Reaction time number correct1.21.72.9-1.71.7-1.3-1.31.01.01.40.9
Reaction time mean minus median0.10.20.4-0.70.5-0.4-0.40.30.30.50.3
Reaction time mean minus median AUC0.40.50.8-0.70.5-0.8-0.80.90.9-0.2-0.5
Reaction time num false alarms0.10.10.4-0.30.20.00.0-0.1-0.10.70.5
Reaction time num false alarms AUC0.00.00.1-0.00.1-0.0-0.0-0.0-0.00.20.1
Reaction time trials correct on left1.21.72.9-1.71.7-1.3-1.31.01.01.40.9
Reaction time trials on left1.21.83.0-1.71.7-1.3-1.31.01.01.40.9
Reaction time mean0.20.30.80.4-0.4-0.0-0.10.30.3-0.9-0.9
Reaction time mean AUC0.30.30.80.7-0.80.40.4-0.2-0.2-0.9-0.7
Median of all reaction times0.50.62.10.7-0.70.10.00.30.3-1.4-1.3
Reaction time omissions0.10.20.6-0.80.4-0.3-0.30.30.30.40.1
Reaction time false alarm rate0.30.40.60.7-0.70.80.8-0.7-0.7-0.2-0.0
Reaction time premature initiation rate1.21.52.5-0.10.5-1.3-1.31.61.6-1.3-1.5
Reaction time premature initiations2.13.05.0-1.21.5-2.1-2.12.22.2-0.6-1.1
Std. dev. reaction times0.50.71.2-1.10.9-1.0-1.01.01.00.3-0.1
Reaction time trials completed1.21.83.0-1.71.7-1.3-1.31.01.01.40.9
Reaction time trials AUC1.31.93.2-1.81.8-1.4-1.31.01.01.40.9
Run reversals in cocaine runway, females1.01.01.6-0.40.5-1.1-1.11.21.2-0.9-1.0
Run reversals in cocaine runway, males1.51.52.21.1-1.21.51.5-1.5-1.50.00.6
Latency to leave start box in cocaine runway0.60.71.21.1-1.10.90.9-0.7-0.7-0.5-0.3
Latency to leave start box in cocaine runway, F1.01.12.01.4-1.40.80.8-0.5-0.5-1.3-1.1
Latency to leave start box in cocaine runway, M0.20.20.7-0.40.4-0.0-0.0-0.1-0.10.80.7
Std. dev. time between licks in bursts1.11.33.6-0.50.30.70.8-1.1-1.11.71.9
Total sessions with >9 infusions3.13.44.8-2.12.1-2.2-2.22.12.10.4-0.2
Short access day 1 total inactive lever presses1.11.22.1-1.41.5-1.2-1.10.90.91.00.7
Short access day 10 total inactive lever presses0.40.40.8-0.80.9-0.6-0.60.40.40.80.5
Short access day 1 total infusions0.50.50.9-0.90.9-0.8-0.80.60.60.60.4
Short access day 10 total infusions0.40.41.3-0.30.20.30.4-0.6-0.60.91.2
Short access total infusions0.60.71.8-1.00.9-0.3-0.2-0.1-0.11.31.3
Short access day 1 locomotion0.30.31.0-0.70.6-0.3-0.30.10.11.00.8
Short access day 10 total locomotion1.11.32.1-0.30.3-1.1-1.11.41.4-1.3-1.5
Short access total locomotion0.60.71.0-0.30.3-0.8-0.81.01.0-0.8-1.0
One hour access (0.3 mA shock)2.83.27.9-2.12.1-0.8-0.70.10.02.82.8
Compulsive drug intake0.60.61.6-0.10.00.50.6-0.8-0.81.01.3
One hour access (shock baseline)1.01.12.2-1.51.4-1.1-1.10.80.80.90.7
Social response proportion3.13.35.4-1.31.3-2.1-2.22.32.3-1.0-1.6
Social responses3.64.68.0-2.72.8-2.3-2.31.91.91.81.0
Social time1.31.82.8-1.01.3-1.6-1.71.71.7-0.1-0.7
Soleus weight4.111.918.4-2.93.3-4.2-4.34.34.3-0.4-1.7
Bone: stiffness0.20.31.5-1.20.5-0.5-0.50.50.50.1-0.1
Tibialis anterior weight0.10.31.0-0.10.30.20.3-0.5-0.51.01.0
Time to tail flick, vehicle, before self-admin1.21.32.0-1.41.4-1.3-1.21.01.00.80.4
Time to tail flick, vehicle, after self-admin0.30.30.90.3-0.2-0.3-0.30.40.4-0.9-0.8
Time to tail flick, test, before self-admin1.81.83.1-0.30.4-1.3-1.41.61.6-1.4-1.8
Time to tail flick, test, after self-admin1.51.52.6-1.61.6-1.4-1.31.21.20.70.3
Delta time to tail flick, vehicle, before/after SA0.20.20.30.6-0.60.40.4-0.3-0.3-0.5-0.4
Delta time to tail flick, test, before/after SA0.80.71.6-1.21.1-0.6-0.60.30.31.21.0
Tibia length1.43.96.0-1.91.6-2.3-2.32.42.4-0.7-1.4
Ambulatory time before self-admin1.71.85.50.3-0.3-0.8-0.81.31.3-2.0-2.4
Ambulatory time after self-admin2.42.64.6-0.30.3-1.5-1.51.91.9-2.0-2.1
Bone: tissue strength0.30.30.40.2-0.30.60.6-0.7-0.60.30.4
Total heroin consumption1.31.53.1-1.71.6-0.9-0.90.50.51.81.2
Bone: trabecular number0.40.71.7-1.00.9-0.4-0.30.00.01.31.2
Bone: trabecular spacing0.20.20.30.4-0.40.50.5-0.6-0.60.10.3
Bone: trabecular thickness4.75.610.0-3.23.0-2.5-2.42.02.02.11.2
Bone: trabecular tissue density0.20.20.7-0.1-0.3-0.1-0.10.30.3-0.8-0.9
Water consumed over 24 hours0.91.01.6-0.50.5-1.1-1.11.31.3-0.9-1.2
Number of responses in last shaping day0.20.20.3-0.20.4-0.5-0.50.50.5-0.0-0.4