Hub : Genes

Acsl5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Acsl5 0.08 0.06 2.0e-08 0.04 0.05 0.06 0.06 1.7e-06 6.0e-08 4.1e-09 9.2e-09
2 Liver gene expression Acsl5 0.05 0.04 2.3e-05 0.04 0.03 0.04 0.03 4.7e-05 1.5e-04 6.4e-05 1.0e-04
3 pVTA gene expression Acsl5 0.03 0.02 9.0e-03 0.03 0.02 0.02 0.02 2.5e-03 1.0e-02 6.5e-03 6.5e-03
4 Adipose gene expression Acsl5 0.02 0.02 5.7e-03 0.02 0.01 0.02 0.02 2.5e-03 1.5e-02 1.4e-03 1.7e-03
5 OFC gene expression Acsl5 0.28 0.16 2.2e-05 0.17 0.17 0.15 0.14 7.0e-05 7.0e-05 2.4e-04 3.7e-04
6 Liver mRNA stability Acsl5 0.07 0.05 2.6e-09 0.06 0.07 0.07 0.06 1.3e-07 2.9e-08 3.7e-08 1.0e-07
7 PL mRNA stability Acsl5 0.04 0.03 4.5e-03 0.02 0.02 0.01 0.02 1.2e-03 5.9e-03 2.2e-02 4.2e-03
8 IC intron excision ratio chr1_264299839_264315405 0.07 0.06 5.8e-03 0.04 0.02 0.04 0.04 1.1e-02 3.7e-02 5.8e-03 1.0e-02
9 IC mRNA stability Acsl5 0.08 0.06 3.0e-03 0.05 0.04 0.02 0.03 4.0e-03 6.5e-03 4.6e-02 1.5e-02
10 NAcc intron excision ratio chr1_264299839_264315405 0.02 0.02 1.7e-03 0.02 0.02 0.01 0.01 9.1e-04 1.3e-03 2.3e-03 2.1e-03
11 pVTA mRNA stability Acsl5 0.08 0.06 3.2e-05 0.06 0.06 0.05 0.06 3.2e-05 3.1e-05 3.4e-05 2.5e-05
12 PL isoform ratio XM_039093168.2 0.46 0.21 5.0e-03 -0 0.01 0.01 0.01 3.9e-01 5.2e-02 1.2e-02 5.1e-02
13 PL intron excision ratio chr1_264299839_264315405 0.04 0.03 4.2e-03 0.01 0.02 0.02 0.01 8.9e-03 4.8e-03 3.3e-03 2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.62.96.6-2.6-1.9-2.1-1.7-1.71.32.0-2.01.8-1.80.6-1.00.3
Area under the delay curve0.61.02.0-1.1-0.8-1.1-0.4-0.60.31.4-1.41.4-1.4-0.4-1.0-0.8
BMI with tail7.024.450.6-7.0-7.1-6.8-6.8-6.76.32.0-1.81.9-2.24.10.72.8
BMI without tail2.111.326.3-4.5-5.1-4.7-4.7-4.64.31.2-1.11.3-1.52.2-1.61.8
Body weight7.733.969.7-8.4-8.3-8.2-7.8-7.97.32.8-2.62.7-3.14.6-0.62.6
Weight adjusted by age1.75.010.3-2.4-3.0-2.9-3.2-2.82.9-0.50.5-0.00.21.9-1.03.1
Bone surface0.51.12.7-1.6-1.5-1.3-1.5-1.11.00.6-0.60.9-0.60.8-0.30.6
Bone volume2.14.19.7-3.1-2.7-2.7-2.6-2.52.21.5-1.41.6-1.31.5-0.21.0
Breakpoint value in progressive ratio session0.81.43.5-0.9-0.8-0.8-0.2-0.4-0.01.7-1.71.9-1.7-0.8-0.9-1.1
Number of licking bursts0.41.23.3-0.9-1.0-0.6-0.2-0.3-0.01.7-1.71.6-1.8-0.5-0.2-0.9
Context. condit. distance diff. score0.60.72.00.80.50.60.20.5-0.1-1.11.0-1.31.2-0.1-1.41.0
Locomotion velocity, session 11.61.84.21.61.61.82.11.9-2.00.6-0.70.4-0.5-1.4-0.00.3
Locomotion distance, session 10.30.41.00.80.70.80.50.6-0.4-0.50.5-1.00.7-0.0-0.50.8
Locomotion velocity, session 21.31.63.91.01.11.10.30.7-0.3-1.71.7-2.01.90.60.11.7
Locomotion distance, session 21.01.32.5-1.6-1.5-1.5-1.4-1.61.50.6-0.60.1-0.61.1-0.51.3
Locomotion velocity, session 30.30.32.40.0-0.00.1-0.10.00.1-0.30.3-0.70.00.0-1.51.0
Locomotion distance, session 30.80.95.4-0.1-0.3-0.3-0.6-0.50.8-0.70.7-1.50.70.5-1.22.3
Stereotopy head waving bouts, day 30.20.31.4-0.3-0.3-0.30.0-0.30.20.5-0.50.4-0.60.11.20.8
Stereotopy head waving duration, day 30.70.81.60.90.81.11.31.1-1.30.6-0.60.6-0.7-1.10.7-0.4
Locomotion velocity, session 70.20.21.6-0.4-0.1-0.3-0.3-0.10.10.4-0.40.4-0.4-0.1-1.30.4
Locomotion distance, session 70.20.31.60.10.30.1-0.10.10.1-0.50.5-0.80.60.3-1.30.4
Stereotopy head waving bouts, day 70.10.10.3-0.2-0.4-0.1-0.1-0.10.00.4-0.40.4-0.5-0.10.5-0.2
Stereotopy head waving duration, day 70.40.51.2-0.6-1.0-0.4-0.4-0.40.20.9-0.81.0-1.1-0.10.5-0.9
Locomotion velocity, session 80.91.12.61.31.51.61.21.4-1.2-0.90.8-1.00.7-0.20.2-0.0
Locomotion distance, session 80.40.73.00.40.30.4-0.10.20.1-0.90.9-1.31.00.2-1.70.9
Degree of sensitization distance0.90.94.40.60.90.90.91.1-1.30.4-0.41.0-0.4-0.8-0.1-2.1
Degree of sensitization stereotypy0.20.20.7-0.3-0.5-0.3-0.1-0.20.00.7-0.70.8-0.8-0.3-0.3-0.5
Conditioned locomotion0.00.10.20.00.30.20.10.00.1-0.30.3-0.20.20.30.40.3
Cocaine response after cond. corrected0.91.42.91.71.21.21.01.1-0.8-1.41.3-1.21.3-0.8-1.50.2
Cocaine response after cond. not corrected1.42.14.62.11.81.71.61.6-1.4-1.41.4-1.31.3-1.0-0.8-0.4
Cocaine response before conditioning0.50.72.30.50.80.80.91.0-1.00.3-0.40.4-0.5-0.41.5-1.1
Saline control response0.71.01.81.21.31.31.01.1-0.9-0.90.9-1.31.2-0.20.4-0.0
Bone: connectivity density0.10.11.4-0.30.2-0.0-0.30.2-0.20.2-0.20.2-0.2-0.1-1.20.1
Bone: cortical apparent density2.74.310.82.01.71.60.51.1-0.4-3.23.2-3.33.20.60.21.5
Bone: cortical area4.47.216.1-3.7-4.0-3.4-3.2-3.22.72.3-2.22.5-2.21.2-1.50.7
Bone: cortical porosity0.50.51.6-0.40.1-0.10.20.1-0.31.1-1.11.0-1.3-0.6-0.9-0.3
Bone: cortical porosity1.01.13.3-0.9-0.4-0.6-0.1-0.40.01.6-1.61.6-1.8-0.6-1.2-0.6
Bone: cortical thickness2.33.88.0-2.7-2.8-2.5-2.6-2.52.31.1-1.01.1-0.91.4-1.51.1
Bone: cortical thickness1.51.93.5-1.7-1.9-1.6-1.9-1.81.80.1-0.10.0-0.11.80.61.3
Bone: cortical tissue density2.84.410.92.21.81.70.61.3-0.6-3.23.2-3.33.20.60.31.4
Condit. Reinf. active minus inactive responses0.80.93.30.80.30.40.90.6-0.70.8-0.80.2-0.7-1.5-1.81.3
Condit. Reinf. active-inactive response ratio0.80.92.51.20.70.81.11.0-1.00.4-0.4-0.0-0.3-1.6-1.51.0
Condit. Reinf. active responses1.01.33.1-0.1-0.4-0.50.3-0.2-0.11.7-1.70.9-1.6-1.2-1.81.4
Condit. Reinf. inactive responses1.01.33.7-1.0-0.8-1.0-0.3-0.70.41.9-1.91.4-1.9-0.5-0.80.4
Incentive salience index mean1.01.33.61.41.00.91.41.2-1.20.6-0.70.0-0.6-1.9-1.71.0
Condit. Reinf. lever presses0.60.92.01.21.21.01.41.2-1.30.5-0.50.1-0.6-1.4-0.60.0
Condit. Reinf. active minus inactive responses2.74.29.50.8-0.40.61.51.1-1.72.7-2.82.5-2.4-3.1-2.9-1.2
Condit. Reinf. active-inactive response ratio1.82.98.51.40.11.01.71.4-1.81.7-1.81.6-1.5-2.9-2.5-1.3
Condit. Reinf. active responses2.73.99.4-0.3-1.0-0.30.60.3-1.03.0-3.12.8-2.8-2.4-2.7-0.9
Condit. Reinf. inactive responses0.81.12.5-1.1-0.7-0.9-0.5-0.50.21.5-1.51.5-1.6-0.4-1.40.0
Condit. Reinf. lever presses1.21.74.4-0.1-0.5-0.10.50.4-0.82.1-2.12.0-1.7-1.8-1.5-0.7
Condit. Reinf. lever reinforcers received2.63.78.5-0.1-0.8-0.20.70.4-1.12.9-2.92.7-2.5-2.5-2.8-0.8
Conditioned reinforcement - actives0.20.61.70.20.1-0.00.50.3-0.61.1-1.11.0-0.9-1.1-1.3-0.3
Conditioned reinforcement - inactives0.30.81.6-0.8-0.8-1.0-0.5-0.60.41.2-1.21.2-1.2-0.5-1.00.6
Conditioned locomotion0.30.52.5-0.30.10.1-0.4-0.10.3-0.60.6-0.60.70.91.6-0.8
Patch foraging indifference point 0 sec1.02.95.9-2.3-2.4-2.4-2.1-2.32.11.0-1.01.0-1.11.0-0.41.0
Patch foraging indifference point AUC0.61.54.0-1.2-0.4-0.80.0-0.3-0.12.0-1.92.0-2.00.01.1-0.3
Delay disc. indifference point, 0s delay0.91.13.4-1.8-1.2-1.3-1.6-1.21.10.5-0.50.7-0.60.9-0.3-0.1
Delay disc. indifference point, 16s delay0.40.61.6-0.2-0.1-0.40.40.1-0.41.1-1.11.3-1.1-0.8-0.6-1.1
Delay disc. indifference point, 2s delay0.10.10.6-0.4-0.1-0.2-0.3-0.20.20.1-0.0-0.1-0.00.40.5-0.8
Delay disc. indifference point, 24s delay1.01.74.4-0.7-0.7-0.90.5-0.3-0.22.0-2.02.0-2.1-0.7-0.2-1.5
Delay disc. indifference point, 4s delay0.60.64.1-0.1-0.2-0.30.3-0.0-0.20.8-0.80.8-0.9-0.8-2.0-0.6
Delay disc. indifference point, 8s delay1.52.64.7-2.2-1.9-2.1-1.4-1.51.01.9-1.91.8-1.90.0-1.0-0.5
Indifference point function ln k0.20.62.80.90.40.80.40.5-0.2-0.90.9-1.00.9-0.3-1.7-0.4
Indifference point function log k0.20.62.80.90.40.80.40.5-0.2-0.90.9-1.00.9-0.3-1.7-0.4
Patch foraging total patch changes 0 sec1.02.95.7-2.4-2.4-2.4-2.0-2.32.01.3-1.21.2-1.30.9-0.20.8
Patch foraging total patch changes 12 sec1.11.53.4-1.5-1.1-1.4-0.6-1.00.71.8-1.81.6-1.8-0.0-0.50.1
Patch foraging total patch changes 18 sec1.74.08.6-2.5-1.9-2.1-1.1-1.71.12.9-2.92.7-2.90.3-0.0-0.1
Patch foraging total patch changes 24 sec1.03.310.1-1.8-1.0-1.6-0.5-0.90.42.8-2.72.9-3.2-0.7-0.2-0.7
Patch foraging total patch changes 6 sec2.54.18.0-2.8-2.8-2.7-2.2-2.52.21.8-1.81.8-1.81.0-0.30.9
Patch foraging time to switch 0 sec0.31.12.21.51.11.30.81.0-0.7-1.21.1-1.21.1-0.5-1.0-0.7
Patch foraging water rate 0 sec0.20.92.2-1.5-1.0-1.2-0.9-1.00.91.0-1.00.7-0.70.60.71.1
Patch foraging water rate 12 sec0.21.01.9-1.3-1.4-1.2-0.8-1.10.91.1-1.11.0-0.90.30.20.6
Patch foraging water rate 18 sec0.30.61.7-0.9-1.3-0.9-1.1-1.01.0-0.00.1-0.20.10.7-0.00.9
Patch foraging water rate 24 sec1.72.45.5-2.3-2.4-2.1-1.9-1.91.71.1-1.10.9-0.90.9-0.60.9
Patch foraging water rate 6 sec0.71.04.0-0.9-1.0-0.4-0.9-0.70.9-0.20.2-0.80.51.42.01.1
Seeking ratio, delayed vs. immediate footshock0.10.10.60.20.30.50.30.3-0.2-0.20.2-0.3-0.10.40.4-0.8
Distance traveled before self-admin1.43.18.00.80.60.6-0.60.10.5-2.82.8-2.72.81.50.92.0
Distance traveled after self-admin1.42.55.1-0.5-0.4-0.5-1.5-0.81.3-2.22.3-1.92.22.11.61.5
Extensor digitorum longus weight0.41.63.3-1.8-1.2-1.6-1.2-1.51.31.3-1.21.1-1.50.8-0.20.8
Bone: elastic displacement0.40.44.5-0.10.0-0.3-0.1-0.10.00.5-0.50.4-0.4-0.6-2.1-0.2
Bone: elastic work1.11.53.1-1.3-1.2-1.4-1.8-1.61.7-0.60.6-0.60.61.4-1.11.1
Bone: endosteal estimation1.33.26.4-2.5-2.5-2.3-2.0-2.01.61.6-1.61.9-1.70.80.10.5
Bone: endosteal perimeter1.84.411.5-3.0-3.4-2.6-2.8-2.52.21.5-1.41.7-1.41.30.50.8
Epididymis fat weight4.924.647.2-6.9-6.8-6.7-5.8-6.05.14.2-4.14.4-4.52.2-2.01.6
Delta time in closed arm before/after self-admin1.11.03.90.2-0.1-0.2-0.5-0.40.6-1.11.1-1.11.11.31.52.0
Delta time in open arm before/after self-admin1.01.12.7-1.2-1.0-1.0-0.6-0.60.21.2-1.21.6-1.3-0.3-0.8-1.6
Diff in mean of infusions in LGA sessions0.81.43.51.91.41.41.61.4-1.3-0.10.1-0.20.1-1.5-1.50.4
Delay discount exponential model param0.81.12.21.00.91.10.30.6-0.3-1.41.4-1.41.50.41.00.9
Extinction: sum of active levers before priming0.81.23.00.10.40.30.90.6-1.01.4-1.51.5-1.5-1.0-0.4-1.7
Active lever presses in extinction session 60.40.41.1-0.9-0.7-0.7-0.6-0.50.40.4-0.40.6-0.50.61.0-0.6
Bone: final force1.11.84.5-1.9-2.1-1.6-1.8-1.61.40.9-0.80.8-0.91.10.61.0
Bone: final moment1.52.55.7-2.3-2.4-2.0-2.0-1.91.71.1-1.11.0-1.11.20.31.1
Food consumed during 24 hour testing period0.20.42.7-0.1-0.3-0.1-0.2-0.10.20.2-0.2-0.50.1-0.2-1.61.3
Glucose1.21.93.8-1.7-1.5-1.6-1.9-1.82.0-0.30.4-0.50.51.81.31.1
Heart weight2.03.27.1-2.0-2.3-2.3-2.1-2.01.81.0-1.00.9-1.00.2-2.72.3
Delay discount hyperbolic model param0.60.81.50.90.81.00.30.6-0.4-1.21.2-1.21.20.21.00.6
Intermittent access intake day 1-15 change0.31.93.5-1.8-1.9-1.9-1.6-1.71.51.1-1.01.0-1.10.6-0.71.1
Intermittent access intake escalation0.41.93.6-1.9-1.9-1.9-1.6-1.71.51.1-1.11.1-1.20.6-0.71.1
Intermittent access intake escalation 20.61.02.1-1.4-1.3-1.4-1.2-1.21.00.8-0.80.9-0.90.5-0.40.5
Intermitt. access day 1 inactive lever presses0.22.85.2-2.2-1.8-2.1-1.2-1.40.92.2-2.22.2-2.3-0.2-0.3-0.8
Intermitt. access day 15 inactive lever presses0.10.41.4-0.1-0.4-0.5-0.1-0.1-0.10.7-0.70.9-0.9-0.8-1.2-0.0
Intermitt. access escalation Index0.10.41.5-0.7-0.3-0.2-0.6-0.50.6-0.40.4-0.70.61.11.20.3
Intermittent access day 1 total infusions0.20.72.1-0.8-0.6-0.5-0.1-0.3-0.01.4-1.41.2-1.1-0.6-0.8-0.4
Intermittent access day 15 total infusions0.61.42.7-1.3-1.2-1.2-0.8-0.90.61.5-1.51.4-1.5-0.4-1.60.7
Intermittent access terminal intake (last 3 days)0.30.61.1-0.9-0.8-0.8-0.6-0.60.41.0-1.01.0-1.0-0.2-1.00.1
Intermittent access total infusions0.91.12.3-1.3-1.1-1.0-0.7-0.70.41.5-1.51.4-1.5-0.3-0.8-0.3
Intermittent access day 1 locomotion0.20.40.9-0.3-0.5-0.2-0.7-0.50.6-0.70.7-0.60.70.7-0.20.9
Intermittent access day 15 total locomotion0.51.83.9-2.0-1.9-1.9-2.0-1.71.60.4-0.30.8-0.71.0-0.70.7
Intermittent access total locomotion0.70.91.9-0.9-0.9-0.7-1.4-1.01.2-0.90.9-0.60.61.40.10.8
Intermittent access standard deviation0.21.12.8-1.2-1.1-1.0-0.5-0.80.41.7-1.71.4-1.5-0.3-0.3-0.2
Left kidney weight1.310.122.8-4.0-3.6-3.9-4.8-4.24.5-0.91.0-1.10.73.70.13.1
Right kidney weight1.913.127.0-4.5-4.3-4.6-5.2-4.85.0-0.20.3-0.50.23.5-0.94.6
Cocaine induced anxiety1.02.64.72.01.91.81.21.5-1.1-2.22.1-1.92.00.31.0-0.3
Post-drug Anxiety0.10.10.60.10.2-0.0-0.00.1-0.1-0.50.5-0.20.40.20.3-0.8
Baseline Anxiety1.72.86.3-2.0-1.7-1.8-0.9-1.30.72.5-2.52.2-2.4-0.4-0.6-0.6
Tail length0.31.48.8-1.0-1.1-1.2-0.9-1.00.90.6-0.60.8-0.9-0.2-3.0-0.5
Length with tail1.35.611.5-3.4-3.1-3.3-3.0-3.22.91.2-1.11.3-1.31.8-1.80.1
Length without tail2.211.527.3-5.2-4.3-4.7-4.2-4.43.92.4-2.32.3-2.42.80.20.1
Times rat made contact with spout1.11.23.4-1.8-1.3-1.4-1.3-1.51.40.8-0.80.3-0.61.0-0.00.7
Lifetime Intake1.11.42.8-1.3-1.2-1.1-0.7-0.80.41.7-1.71.6-1.6-0.4-1.1-0.4
Liver weight, left3.15.311.4-3.4-3.4-3.1-3.2-3.02.71.3-1.21.7-1.51.60.20.3
Liver weight, right5.69.819.9-4.5-4.1-4.0-4.4-4.34.30.5-0.30.5-0.53.51.71.6
Locomotor activity1.11.73.6-1.1-1.3-0.9-1.7-1.31.5-1.11.1-0.80.61.61.31.9
Locomotor testing distance1.12.74.4-0.9-1.2-0.9-2.0-1.31.7-2.02.0-1.61.52.11.52.1
Locomotor testing rearing0.41.43.1-1.0-1.2-1.1-1.8-1.31.5-1.31.3-0.80.81.30.50.9
Locomotion in novel chamber1.21.64.30.1-0.1-0.0-0.9-0.50.9-1.92.0-2.12.01.20.11.1
Locomotion in novel chamber post-restriction0.31.02.51.31.61.21.11.2-1.0-0.60.7-0.80.9-0.6-1.00.8
Fecal boli incidents, locomotor time 10.10.21.9-0.10.20.0-0.10.3-0.40.3-0.40.5-0.5-0.30.1-1.4
Change in fecal boli incidents, locomotor task0.40.41.70.90.40.30.70.3-0.3-0.40.30.2-0.1-0.5-1.11.3
Time >=10cm from walls, locomotor time 10.50.71.90.81.41.10.81.0-0.9-0.50.5-0.50.5-0.30.4-1.0
Bouts of movement, locomotor time 11.72.24.7-1.9-1.4-1.7-1.2-0.90.42.0-2.02.2-2.2-0.4-0.5-0.3
Total resting periods, locomotor time 11.61.83.8-1.5-1.4-1.7-0.7-0.90.51.9-2.01.9-1.9-0.3-0.3-0.2
Rest time, locomotor task time 10.20.41.5-0.3-0.9-1.0-0.2-0.70.70.2-0.10.2-0.10.3-0.01.2
Distance moved, locomotor task time 10.00.10.4-0.20.20.1-0.2-0.00.1-0.20.2-0.40.20.3-0.3-0.7
Vertical activity count, locomotor time 10.21.43.21.00.91.10.10.5-0.2-1.81.7-1.71.60.2-1.31.2
Time >=10cm from walls, locomotor time 20.20.61.5-1.2-0.7-0.9-1.1-0.80.70.3-0.30.8-0.70.50.5-1.0
Bouts of movement, locomotor time 20.10.41.00.81.00.90.51.0-0.9-0.40.3-0.10.1-0.6-0.4-0.3
Total resting periods, locomotor time 20.00.20.40.40.60.50.30.7-0.7-0.20.10.1-0.1-0.4-0.4-0.2
Rest time, locomotor task time 20.20.31.20.10.00.1-0.2-0.10.2-0.80.9-1.10.90.5-0.1-0.1
Distance moved, locomotor task time 20.50.61.5-0.8-0.3-0.4-0.6-0.1-0.21.0-1.11.2-1.2-0.7-0.9-0.2
Vertical activity count, locomotor time 20.20.41.8-1.1-0.5-0.5-1.3-0.40.30.3-0.30.4-0.30.1-0.50.6
Light reinforcement 10.21.12.31.51.41.41.21.4-1.4-0.80.7-0.10.1-0.9-0.0-0.8
Light reinforcement 20.61.32.51.51.61.51.21.5-1.4-1.00.9-0.70.6-0.7-0.3-1.1
Bone: marrow area1.33.26.6-2.6-2.5-2.3-2.0-2.11.71.7-1.61.9-1.70.80.20.5
Bone: maximum diameter3.97.816.9-4.0-4.1-3.5-3.2-3.22.72.4-2.42.9-2.51.5-0.1-0.6
Bone: maximum force0.61.33.6-1.5-1.9-1.2-1.5-1.31.10.9-0.80.7-0.80.70.20.8
Bone: maximum moment0.91.74.4-1.8-2.1-1.6-1.6-1.51.31.1-1.10.9-1.10.7-0.20.9
Mean time between licks in bursts0.21.02.3-0.2-0.2-0.20.30.1-0.41.5-1.51.4-1.3-1.4-1.5-0.0
Mean num. licks in bursts0.51.42.7-0.6-0.2-0.7-1.1-1.01.3-1.31.4-1.51.61.50.31.6
Cd content in liver2.02.26.01.20.40.6-0.20.20.3-2.42.5-2.42.40.60.61.7
Co content in liver1.21.43.51.11.30.80.40.6-0.2-1.91.8-1.71.70.51.20.6
Cu content in liver0.10.20.40.10.40.2-0.10.2-0.0-0.60.6-0.50.50.30.7-0.0
Fe content in liver1.01.22.3-1.2-0.8-1.1-0.6-0.90.51.3-1.41.4-1.5-0.3-1.5-0.9
K content in liver0.30.31.20.31.00.60.30.7-0.6-0.50.4-0.30.2-0.10.1-1.1
Mg content in liver0.20.22.10.00.50.30.10.4-0.5-0.10.00.1-0.1-0.3-0.3-1.4
Mn content in liver0.10.10.20.40.30.40.20.4-0.3-0.40.4-0.40.3-0.10.20.2
Na content in liver1.01.22.51.31.01.41.41.5-1.60.2-0.20.1-0.2-1.4-0.6-1.1
Rb content in liver1.31.53.11.01.41.11.41.3-1.50.7-0.70.8-0.8-1.6-1.3-1.8
Se content in liver1.01.12.41.21.41.51.21.5-1.5-0.30.3-0.40.4-0.9-0.9-0.9
Sr content in liver2.01.73.11.61.41.50.91.3-1.0-1.81.7-1.71.7-0.40.1-0.2
Zn content in liver0.60.71.70.71.10.70.40.6-0.3-1.21.1-1.31.20.20.7-0.1
Bone: minimum diameter2.64.99.8-3.0-3.1-2.9-2.6-2.62.21.8-1.82.2-1.70.9-1.31.2
Time in familiar zone, hab. session 11.01.13.21.10.70.80.20.6-0.2-1.81.8-1.51.60.10.20.3
Time in novel zone, hab. session 11.31.43.5-1.3-1.1-0.9-0.5-0.60.21.9-1.91.7-1.8-0.1-0.8-0.4
Total zone transitions, hab. session 11.21.73.7-1.6-1.6-1.6-1.6-1.61.60.3-0.2-0.2-0.41.3-0.91.9
Total locomotion distance, hab. session 10.20.32.2-0.4-0.5-0.3-0.1-0.20.10.7-0.70.3-0.60.0-1.50.2
Locomotion velocity, hab. session 10.20.32.6-0.3-0.3-0.30.0-0.10.00.7-0.70.2-0.6-0.0-1.60.4
Time in familiar zone, hab. session 22.52.96.6-1.7-2.0-1.8-0.9-1.51.02.2-2.22.5-2.6-0.3-0.60.0
Time in novel zone, hab. session 21.41.54.41.11.21.00.30.8-0.3-1.81.8-2.02.10.4-0.20.6
Total zone transitions, hab. session 21.82.34.4-1.6-1.9-2.0-1.7-2.01.90.5-0.50.2-0.50.9-1.52.1
Total locomotion distance, hab. session 21.01.32.5-1.4-1.5-1.6-1.2-1.51.40.7-0.60.4-0.60.7-1.41.1
Locomotion velocity, hab. session 20.60.81.4-1.0-1.1-1.2-0.9-1.21.10.5-0.40.1-0.30.7-1.00.8
Novel to familiar place preference ratio0.10.10.4-0.00.10.00.30.2-0.30.6-0.60.5-0.5-0.30.10.3
Novelty place preference0.10.10.4-0.2-0.1-0.10.10.0-0.20.6-0.60.7-0.5-0.20.10.1
Time in novel zone, NPP test0.40.51.4-0.6-0.6-0.5-0.1-0.30.01.1-1.11.2-1.0-0.3-0.30.2
Total zone transitions, NPP test1.52.34.1-2.0-1.9-2.0-1.5-1.91.71.3-1.30.8-1.30.9-0.51.5
Total locomotion distance, NPP test1.21.72.6-1.5-1.6-1.6-1.0-1.51.31.5-1.51.0-1.30.4-1.20.9
Locomotion velocity, NPP test0.50.71.3-1.0-1.1-1.1-0.7-1.11.00.8-0.80.2-0.60.5-0.60.5
Intraocular pressure2.54.17.2-2.3-2.7-2.6-1.7-2.21.72.3-2.22.2-2.2-0.0-1.41.4
Delta distance traveled before/after self-admin0.91.02.3-1.5-1.3-1.3-1.3-1.21.10.2-0.20.5-0.31.11.1-0.2
Delta ambulatory time before/after self-admin0.81.43.2-1.8-1.4-1.5-1.1-1.20.91.1-1.11.3-1.20.60.7-0.8
Parametrial fat weight7.517.734.1-5.7-5.8-5.6-4.5-4.94.04.0-3.94.3-4.11.4-1.31.3
Pavlov. Cond. lever latency0.40.41.0-0.9-1.0-0.9-0.6-0.80.60.7-0.70.8-0.30.3-0.30.4
Pavlov. Cond. magazine entry latency0.30.40.8-0.9-0.4-0.9-0.5-0.80.70.7-0.60.4-0.70.50.10.8
Pavlov. Cond. change in total contacts0.20.20.8-0.00.2-0.1-0.2-0.10.3-0.50.5-0.70.30.50.30.9
Pavlov. Cond. index score0.20.20.5-0.5-0.1-0.5-0.5-0.60.7-0.20.2-0.4-0.20.70.60.6
Pavlov. Cond. latency score0.10.20.4-0.3-0.0-0.4-0.4-0.40.5-0.30.3-0.4-0.10.60.50.3
Pavlov. Cond. lever contacts0.40.51.01.01.00.90.80.9-0.8-0.50.5-0.60.2-0.50.4-0.4
Pavlov. Cond. magazine entry number1.01.22.41.41.01.51.31.5-1.5-0.30.20.10.4-1.2-0.5-1.5
Pavlov. Cond. intertrial magazine entries0.20.31.8-0.3-0.6-0.5-0.4-0.40.30.3-0.30.3-0.3-0.2-1.30.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.5-0.4-0.0-0.4-0.3-0.50.5-0.10.1-0.3-0.30.60.70.4
Pavlov. Cond. response bias0.10.10.5-0.00.2-0.2-0.1-0.20.2-0.20.2-0.4-0.10.30.30.7
Pavlov. Cond. lever latency1.52.16.00.20.30.0-0.7-0.51.0-2.42.4-2.21.91.71.40.8
Pavlov. Cond. magazine entry latency1.21.83.3-1.8-1.3-1.6-1.1-1.20.91.8-1.81.6-1.60.1-0.3-0.2
Pavlov. Cond. change in total contacts1.23.07.8-0.7-0.8-0.70.3-0.1-0.42.8-2.82.5-2.3-1.7-2.7-0.6
Pavlov. Cond. index score1.52.47.1-1.2-1.1-1.0-0.2-0.5-0.02.7-2.72.3-2.1-1.1-1.4-0.5
Pavlov. Cond. latency score1.42.36.8-1.4-1.1-1.1-0.4-0.60.12.6-2.62.3-2.1-0.8-1.0-0.4
Pavlov. Cond. lever contacts1.01.54.4-0.3-0.4-0.20.40.2-0.62.1-2.11.8-1.5-1.4-1.5-0.3
Pavlov. Cond. magazine entry number1.31.74.41.61.21.40.81.1-0.7-2.12.1-1.71.60.10.5-0.2
Pavlov. Cond. intertrial magazine entries0.00.10.30.1-0.50.1-0.40.00.0-0.60.6-0.10.10.30.2-0.2
Pavlov. Cond. lever-magazine prob. diff.1.32.06.2-1.2-1.1-1.0-0.3-0.50.12.5-2.52.1-1.8-0.9-1.1-0.4
Pavlov. Cond. response bias1.52.16.4-0.8-0.8-0.70.1-0.2-0.32.5-2.52.2-1.9-1.3-1.7-0.3
Time in closed arm before self-admin0.20.42.80.60.20.30.20.3-0.2-0.50.5-0.30.4-0.6-1.70.1
Time in closed arm after self-admin0.60.71.81.30.60.70.50.5-0.3-1.01.0-0.91.0-0.3-0.71.4
Time in open arm before self-admin0.91.14.40.91.41.41.21.2-1.1-0.20.2-0.40.20.02.1-1.1
Time in open arm after self-admin1.01.15.2-0.8-0.0-0.10.20.2-0.51.2-1.21.4-1.3-0.31.0-2.3
Bone: periosteal estimation3.37.716.5-4.0-4.1-3.6-3.4-3.42.92.2-2.12.5-2.11.6-0.61.0
Bone: periosteal perimeter4.48.619.9-4.2-4.5-3.7-3.7-3.63.12.2-2.12.4-2.11.90.10.7
Bone: post-yield work0.71.22.60.3-0.30.30.90.5-0.81.6-1.61.5-1.6-1.31.2-0.9
Progressive ratio test 1 active lever presses0.81.53.2-1.0-1.2-1.0-0.6-0.70.31.6-1.61.8-1.6-0.8-1.80.3
Progressive ratio test 1 breakpoint0.81.43.5-0.9-1.1-0.9-0.5-0.70.21.6-1.61.8-1.6-0.9-1.90.2
Progressive ratio test 1 inactive lever presses0.82.25.9-1.2-0.9-1.2-0.1-0.5-0.02.4-2.42.3-2.3-1.1-0.9-0.8
Progressive ratio test 2 active lever presses1.82.54.1-2.0-1.7-2.0-1.3-1.41.01.9-1.91.9-1.9-0.2-1.30.7
Progressive ratio test 2 breakpoint2.02.64.5-2.1-1.7-2.1-1.4-1.51.11.9-1.91.9-1.8-0.0-1.30.7
Progressive ratio test 2 inactive lever presses0.62.03.9-1.6-1.4-1.7-0.9-0.90.51.9-1.92.0-2.0-0.5-1.0-0.5
Incentive Sensitization - Responses0.61.73.3-1.8-1.3-1.7-1.0-1.20.91.8-1.71.5-1.50.20.10.4
Incentive Sensitization - Breakpoint0.71.53.1-1.8-1.2-1.6-0.9-1.10.81.7-1.61.4-1.50.30.20.3
Sum of active levers in priming session hrs 5-60.70.72.50.61.00.81.00.9-1.00.4-0.40.4-0.4-0.40.8-1.6
Progressive ratio0.30.71.91.20.81.21.41.1-1.20.3-0.3-0.0-0.2-1.0-0.4-0.5
Food seeking constrained by brief footshock1.31.63.70.40.40.41.20.9-1.31.9-1.91.5-1.8-1.8-0.9-0.3
Seeking ratio, punishment vs. effort0.20.41.0-1.0-0.7-0.9-0.8-0.70.60.6-0.60.7-0.70.2-0.00.4
Retroperitoneal fat weight7.634.268.2-8.3-8.0-8.1-6.8-7.16.04.9-4.75.3-5.12.8-0.91.8
Reaction time number correct0.51.73.7-1.9-1.5-1.6-1.1-1.41.11.6-1.51.5-1.50.6-0.00.1
Reaction time mean minus median0.00.31.0-0.7-0.7-0.5-0.5-0.40.40.3-0.30.3-0.20.41.0-0.2
Reaction time mean minus median AUC0.10.61.6-0.8-0.9-0.7-1.0-0.80.9-0.30.4-0.30.41.01.30.5
Reaction time num false alarms0.10.10.3-0.20.0-0.20.1-0.0-0.10.5-0.50.5-0.5-0.20.30.2
Reaction time num false alarms AUC0.00.00.2-0.20.1-0.2-0.0-0.00.00.2-0.20.2-0.20.00.30.5
Reaction time trials correct on left0.51.73.7-1.9-1.5-1.6-1.1-1.41.11.6-1.51.5-1.50.6-0.00.1
Reaction time trials on left0.51.83.9-2.0-1.6-1.7-1.2-1.41.11.6-1.61.5-1.50.6-0.10.2
Reaction time mean0.30.71.70.1-0.00.1-0.4-0.00.3-1.11.1-1.31.30.91.30.3
Reaction time mean AUC0.30.61.70.50.40.60.00.4-0.1-1.21.1-1.21.30.51.10.2
Median of all reaction times0.71.13.00.30.20.4-0.30.10.3-1.51.5-1.71.71.01.40.5
Reaction time omissions0.10.20.6-0.2-0.7-0.4-0.3-0.20.10.5-0.50.5-0.2-0.3-0.50.4
Reaction time false alarm rate0.20.30.80.90.80.70.70.7-0.7-0.40.3-0.30.3-0.6-0.10.1
Reaction time premature initiation rate0.91.53.9-0.9-0.4-0.8-1.3-1.11.4-1.31.3-1.31.02.01.40.5
Reaction time premature initiations0.82.56.1-2.1-1.4-1.8-2.0-2.02.1-0.40.5-0.60.22.51.60.9
Std. dev. reaction times0.20.71.6-1.2-1.3-1.1-1.2-1.01.00.2-0.10.1-0.00.90.80.5
Reaction time trials completed0.51.83.9-2.0-1.6-1.7-1.2-1.41.11.6-1.61.5-1.50.6-0.10.2
Reaction time trials AUC0.61.94.1-2.0-1.6-1.7-1.2-1.51.11.7-1.61.6-1.60.6-0.20.3
Run reversals in cocaine runway, females0.91.02.0-1.2-1.1-1.0-1.4-1.21.3-0.50.5-0.80.81.30.60.2
Run reversals in cocaine runway, males0.80.91.81.31.01.21.21.3-1.3-0.30.20.1-0.0-1.00.1-1.0
Latency to leave start box in cocaine runway0.50.71.41.11.21.10.91.0-0.9-0.70.7-0.40.7-0.40.0-1.0
Latency to leave start box in cocaine runway, F0.81.02.01.41.31.30.91.1-0.9-1.21.2-0.81.1-0.2-0.1-0.2
Latency to leave start box in cocaine runway, M0.10.10.4-0.3-0.2-0.3-0.1-0.10.00.5-0.50.5-0.5-0.20.0-0.6
Std. dev. time between licks in bursts1.01.93.90.10.10.30.90.7-1.11.9-2.01.9-1.9-1.8-1.3-1.4
Total sessions with >9 infusions1.51.93.5-1.8-1.9-1.9-1.6-1.61.31.2-1.21.0-1.20.3-1.30.8
Short access day 1 total inactive lever presses0.71.43.0-1.7-1.1-1.4-1.0-1.00.71.2-1.11.5-1.50.40.3-1.3
Short access day 10 total inactive lever presses0.10.71.2-1.1-1.0-1.1-0.8-1.00.90.6-0.50.4-0.40.51.10.4
Short access day 1 total infusions0.20.40.9-1.0-0.8-0.9-0.7-0.70.50.6-0.60.8-0.60.3-0.4-0.4
Short access day 10 total infusions0.30.61.40.10.00.20.60.3-0.51.1-1.10.8-0.8-1.0-1.2-0.3
Short access total infusions0.50.71.6-0.8-0.8-0.6-0.3-0.50.21.3-1.31.0-1.1-0.4-0.9-0.3
Short access day 1 locomotion0.30.51.3-0.9-0.8-0.9-0.5-0.40.20.9-0.91.2-1.0-0.1-0.2-0.7
Short access day 10 total locomotion0.52.14.2-0.8-1.1-0.9-1.7-1.31.6-1.71.7-1.41.52.01.01.3
Short access total locomotion0.60.91.8-0.8-1.1-1.0-1.3-1.11.2-0.60.6-0.60.41.1-0.11.3
One hour access (0.3 mA shock)3.44.010.6-1.6-1.2-1.0-0.0-0.4-0.33.3-3.33.2-3.2-1.1-0.3-1.7
Compulsive drug intake1.01.45.8-0.7-0.2-0.20.40.2-0.61.6-1.61.5-1.9-0.50.7-2.4
One hour access (shock baseline)0.20.50.9-0.8-0.9-0.7-0.7-0.70.50.6-0.60.8-0.7-0.0-0.90.6
Social response proportion2.53.16.8-2.0-1.7-1.8-2.3-2.02.3-0.50.6-1.10.92.21.42.6
Social responses3.04.08.4-2.9-2.4-2.8-2.3-2.42.01.7-1.71.8-2.00.90.01.3
Social time1.01.53.2-1.6-1.0-1.7-1.8-1.61.6-0.30.4-0.10.21.61.00.8
Soleus weight3.39.819.3-4.3-3.5-3.9-4.3-4.34.4-0.10.3-0.2-0.44.22.12.0
Bone: stiffness0.10.10.8-0.3-0.90.1-0.5-0.10.10.2-0.20.2-0.10.0-0.00.6
Tibialis anterior weight0.20.62.2-0.10.4-0.10.70.2-0.51.3-1.30.9-1.5-0.8-0.60.2
Time to tail flick, vehicle, before self-admin0.30.41.0-1.0-0.7-0.7-0.8-0.70.70.1-0.0-0.1-0.20.91.0-0.3
Time to tail flick, vehicle, after self-admin0.30.54.1-0.10.60.60.40.5-0.50.4-0.4-0.1-0.2-0.21.0-2.0
Time to tail flick, test, before self-admin1.01.23.1-0.2-0.2-0.2-0.8-0.50.8-1.41.4-1.41.41.30.91.8
Time to tail flick, test, after self-admin0.50.61.2-0.9-0.8-0.6-0.4-0.40.21.1-1.11.0-1.0-0.20.1-1.0
Delta time to tail flick, vehicle, before/after SA0.70.72.00.20.40.40.70.6-0.81.0-1.00.9-0.9-1.1-1.0-1.4
Delta time to tail flick, test, before/after SA0.40.51.3-0.4-0.4-0.20.0-0.1-0.11.0-1.00.9-1.0-0.6-0.2-1.2
Tibia length1.13.17.4-2.1-2.3-2.0-2.7-2.22.4-0.70.8-0.60.52.30.40.9
Ambulatory time before self-admin0.92.96.60.2-0.2-0.2-1.2-0.61.1-2.52.6-2.42.51.70.52.5
Ambulatory time after self-admin1.82.96.6-1.1-0.8-0.8-1.9-1.21.6-2.12.1-1.72.02.62.30.8
Bone: tissue strength0.40.41.90.70.50.40.70.6-0.70.2-0.20.1-0.5-1.1-1.4-0.1
Total heroin consumption2.22.54.4-1.9-2.0-2.1-1.5-1.61.21.8-1.71.7-1.7-0.1-1.60.6
Bone: trabecular number0.51.02.2-1.3-0.7-0.9-0.6-0.50.21.5-1.51.4-1.4-0.2-1.10.1
Bone: trabecular spacing0.10.20.50.70.60.50.70.6-0.6-0.10.10.00.2-0.6-0.2-0.1
Bone: trabecular thickness3.54.811.3-3.4-2.8-2.8-2.5-2.62.21.9-1.82.2-1.91.60.3-0.4
Bone: trabecular tissue density0.40.61.70.8-0.00.80.10.4-0.1-1.21.2-0.91.30.51.2-0.3
Water consumed over 24 hours0.40.81.6-1.2-1.0-0.7-1.3-1.01.1-0.30.3-0.60.41.1-0.31.3
Number of responses in last shaping day0.30.42.3-0.0-0.2-0.40.0-0.20.10.6-0.60.4-0.3-0.5-1.51.0