Hub : Genes

Garem2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	isoform ratio	NM_001191874.1	0.02	0.02	3.3e-03	0.02	0.01	0	0.01	4.5e-03	1.2e-02	1.2e-01	8.6e-03
2	Adipose	gene expression	Garem2	0.03	0.03	7.4e-03	0.01	0.01	0	0.01	1.9e-02	1.7e-02	7.2e-02	2.7e-02
3	Liver	gene expression	Garem2	0.04	0.04	4.8e-04	0.02	0.02	0.02	0.02	2.4e-03	1.5e-03	1.6e-03	2.7e-03
4	PL	isoform ratio	NM_001191874.1	0.02	0.02	4.9e-03	0.01	0.01	0	0.01	2.5e-02	3.6e-02	3.4e-01	4.4e-02
5	LHb	gene expression	Garem2	0.18	0.14	7.9e-04	0.1	0.11	0.11	0.11	1.8e-03	1.6e-03	1.2e-03	1.7e-03
6	Brain	mRNA stability	Garem2	0.07	0.07	5.1e-06	0.06	0.06	0.06	0.06	1.8e-06	2.0e-06	3.4e-06	2.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	3.0	5.1	6.5	-2.5	2.2	2.2	-2.1	-2.2	2.3
Area under the delay curve	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2	0.1	-0.2
BMI with tail	2.6	8.5	9.2	3.0	-2.9	-2.9	2.9	2.9	-2.7
BMI without tail	0.5	1.1	1.2	1.1	-1.0	-1.0	1.0	0.9	-1.1
Body weight	2.1	8.7	9.6	3.1	-2.9	-3.0	2.8	3.1	-2.8
Weight adjusted by age	0.4	0.4	1.1	1.0	-0.6	-0.6	0.6	0.5	-0.6
Bone surface	0.6	1.0	1.7	-1.3	1.0	1.0	-0.9	-0.9	1.0
Bone volume	1.6	2.8	3.8	-1.9	1.6	1.6	-1.6	-1.6	1.7
Breakpoint value in progressive ratio session	1.0	1.0	1.3	-0.9	1.1	1.1	-1.1	-1.0	1.0
Number of licking bursts	1.3	1.5	1.6	1.3	-1.2	-1.2	1.2	1.2	-1.2
Context. condit. distance diff. score	0.2	0.2	0.3	-0.4	0.5	0.5	-0.5	-0.5	0.4
Locomotion velocity, session 1	0.8	0.8	1.2	1.1	-0.9	-0.9	0.9	0.9	-0.7
Locomotion distance, session 1	0.2	0.3	0.4	-0.4	0.6	0.6	-0.6	-0.5	0.6
Locomotion velocity, session 2	0.0	0.0	0.1	0.1	-0.2	-0.2	0.1	0.2	-0.2
Locomotion distance, session 2	0.1	0.1	0.2	0.2	-0.3	-0.3	0.4	0.5	-0.3
Locomotion velocity, session 3	0.0	0.0	0.1	-0.3	0.2	0.2	-0.1	-0.2	0.2
Locomotion distance, session 3	0.0	0.0	0.1	0.1	-0.2	-0.2	0.2	0.3	-0.1
Stereotopy head waving bouts, day 3	2.0	2.4	2.8	-1.3	1.6	1.6	-1.6	-1.7	1.5
Stereotopy head waving duration, day 3	0.5	0.6	0.8	-0.7	0.8	0.8	-0.9	-0.9	0.7
Locomotion velocity, session 7	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.1
Locomotion distance, session 7	0.9	1.2	1.4	1.1	-1.1	-1.1	1.1	1.2	-1.0
Stereotopy head waving bouts, day 7	0.0	0.1	0.3	0.6	0.0	0.0	-0.0	-0.1	0.1
Stereotopy head waving duration, day 7	0.4	0.5	0.7	-0.5	0.7	0.7	-0.7	-0.8	0.7
Locomotion velocity, session 8	0.5	0.6	0.7	-0.7	0.8	0.8	-0.8	-0.8	0.7
Locomotion distance, session 8	0.2	0.3	0.4	-0.5	0.6	0.6	-0.6	-0.6	0.6
Degree of sensitization distance	0.9	0.9	1.0	1.0	-0.9	-0.9	0.9	1.0	-0.9
Degree of sensitization stereotypy	0.4	0.4	0.9	0.9	-0.5	-0.5	0.6	0.5	-0.5
Conditioned locomotion	3.7	4.3	4.6	-2.0	2.1	2.1	-2.0	-2.1	2.1
Cocaine response after cond. corrected	0.2	0.2	0.2	-0.5	0.4	0.4	-0.4	-0.4	0.5
Cocaine response after cond. not corrected	0.8	0.8	0.9	-1.0	0.9	0.9	-0.9	-1.0	0.9
Cocaine response before conditioning	2.1	2.6	3.0	-1.5	1.6	1.6	-1.7	-1.7	1.5
Saline control response	1.6	2.1	3.0	-1.7	1.4	1.4	-1.4	-1.3	1.5
Bone: connectivity density	2.0	3.1	4.6	-2.1	1.7	1.7	-1.6	-1.6	1.7
Bone: cortical apparent density	0.0	0.0	0.2	-0.4	0.1	0.1	-0.0	-0.2	0.0
Bone: cortical area	0.0	0.1	0.1	-0.1	-0.3	-0.3	0.2	0.3	-0.2
Bone: cortical porosity	3.6	3.9	4.3	-1.9	2.0	2.0	-2.0	-2.0	2.1
Bone: cortical porosity	2.8	3.1	3.3	-1.8	1.7	1.7	-1.7	-1.8	1.8
Bone: cortical thickness	0.3	0.4	0.5	0.4	-0.7	-0.7	0.6	0.7	-0.7
Bone: cortical thickness	0.4	0.5	0.5	-0.6	0.7	0.7	-0.7	-0.7	0.7
Bone: cortical tissue density	0.0	0.0	0.1	-0.3	0.0	0.0	0.0	-0.1	-0.1
Condit. Reinf. active minus inactive responses	2.2	2.4	2.9	1.6	-1.5	-1.5	1.5	1.5	-1.7
Condit. Reinf. active-inactive response ratio	1.7	1.9	2.5	1.2	-1.4	-1.4	1.3	1.3	-1.6
Condit. Reinf. active responses	0.2	0.2	0.3	0.4	-0.4	-0.4	0.4	0.4	-0.6
Condit. Reinf. inactive responses	0.9	1.1	1.3	-1.0	1.1	1.1	-1.1	-1.0	1.1
Incentive salience index mean	0.2	0.3	0.4	0.5	-0.5	-0.5	0.5	0.6	-0.6
Condit. Reinf. lever presses	0.5	0.7	0.8	-0.8	0.9	0.8	-0.8	-0.7	0.9
Condit. Reinf. active minus inactive responses	1.2	1.5	1.7	-0.9	1.2	1.2	-1.2	-1.3	1.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.7	-0.5	0.8	0.8	-0.8	-0.9	0.9
Condit. Reinf. active responses	0.6	0.9	1.1	-0.6	1.0	1.0	-1.0	-1.1	0.9
Condit. Reinf. inactive responses	0.1	0.2	0.2	-0.2	0.4	0.4	-0.5	-0.5	0.4
Condit. Reinf. lever presses	0.9	1.3	1.6	-0.8	1.2	1.2	-1.2	-1.3	1.1
Condit. Reinf. lever reinforcers received	0.5	0.8	1.0	-0.6	0.9	0.9	-0.9	-1.0	0.9
Conditioned reinforcement - actives	4.3	4.3	6.4	-2.5	2.0	2.0	-1.9	-2.1	1.9
Conditioned reinforcement - inactives	5.8	6.6	7.7	-2.6	2.5	2.5	-2.5	-2.4	2.8
Conditioned locomotion	3.9	4.6	5.5	-2.4	2.1	2.1	-1.9	-2.1	2.3
Patch foraging indifference point 0 sec	0.5	0.8	1.2	0.9	-0.9	-0.9	0.8	1.1	-0.8
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.1	0.0	0.0	0.0	-0.0	0.3
Delay disc. indifference point, 0s delay	1.1	1.2	1.4	1.1	-1.1	-1.1	1.2	1.2	-0.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2	0.3	-0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.2	-0.3	-0.3	0.4	0.4	-0.4
Delay disc. indifference point, 24s delay	2.6	2.5	2.6	-1.5	1.6	1.6	-1.6	-1.6	1.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.4	-0.5	-0.5	0.5	0.5	-0.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.2	0.1	0.1	-0.0	-0.2	0.1
Indifference point function ln k	1.5	2.1	2.3	-1.3	1.5	1.5	-1.5	-1.4	1.5
Indifference point function log k	1.5	2.1	2.3	-1.3	1.5	1.5	-1.5	-1.4	1.5
Patch foraging total patch changes 0 sec	0.5	0.8	1.2	0.8	-0.9	-0.9	0.8	1.1	-0.7
Patch foraging total patch changes 12 sec	1.0	1.2	1.6	1.1	-1.1	-1.2	1.1	1.3	-1.0
Patch foraging total patch changes 18 sec	0.9	1.1	1.5	1.1	-1.1	-1.1	1.0	1.2	-0.8
Patch foraging total patch changes 24 sec	1.2	1.5	1.6	1.2	-1.2	-1.2	1.2	1.3	-1.1
Patch foraging total patch changes 6 sec	1.8	2.6	2.9	1.6	-1.7	-1.7	1.6	1.7	-1.5
Patch foraging time to switch 0 sec	0.4	0.6	1.0	1.0	-0.7	-0.7	0.6	0.5	-0.9
Patch foraging water rate 0 sec	1.2	1.9	2.5	-1.4	1.3	1.3	-1.3	-1.2	1.6
Patch foraging water rate 12 sec	0.1	0.1	0.1	0.2	-0.3	-0.3	0.3	0.4	-0.4
Patch foraging water rate 18 sec	1.1	1.4	1.6	-1.3	1.2	1.2	-1.3	-1.1	1.2
Patch foraging water rate 24 sec	0.1	0.1	0.2	-0.1	-0.3	-0.3	0.3	0.5	-0.1
Patch foraging water rate 6 sec	0.1	0.2	0.3	-0.4	0.4	0.4	-0.4	-0.3	0.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.0	0.1	0.0
Distance traveled before self-admin	0.2	0.2	0.3	-0.5	0.4	0.4	-0.3	-0.4	0.4
Distance traveled after self-admin	0.2	0.2	0.4	0.4	-0.4	-0.4	0.4	0.6	-0.3
Extensor digitorum longus weight	2.1	8.4	10.8	-3.3	2.8	2.8	-2.8	-2.8	2.8
Bone: elastic displacement	1.7	1.9	2.5	-1.6	1.3	1.3	-1.3	-1.4	1.2
Bone: elastic work	0.4	0.5	0.7	-0.7	0.7	0.7	-0.8	-0.8	0.6
Bone: endosteal estimation	0.1	0.1	0.2	-0.4	0.4	0.3	-0.4	-0.2	0.4
Bone: endosteal perimeter	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.1	0.1	0.1
Epididymis fat weight	16.0	37.2	39.2	5.9	-6.2	-6.1	6.3	6.0	-6.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	0.7	-0.5	-0.5	0.3	0.6	-0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.7	-0.8	0.2	0.2	-0.1	-0.2	0.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	-0.2	0.2
Delay discount exponential model param	0.0	0.0	0.0	0.2	-0.0	-0.0	0.0	0.1	0.0
Extinction: sum of active levers before priming	0.4	0.4	0.7	-0.2	0.7	0.7	-0.8	-0.5	0.7
Active lever presses in extinction session 6	1.8	1.7	2.0	-1.2	1.3	1.3	-1.4	-1.2	1.3
Bone: final force	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.2	-0.1
Bone: final moment	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.2	-0.1
Food consumed during 24 hour testing period	0.1	0.1	0.4	0.6	-0.3	-0.3	0.3	0.2	-0.2
Glucose	0.3	0.4	0.7	0.8	-0.6	-0.6	0.6	0.5	-0.6
Heart weight	4.5	6.4	7.2	2.1	-2.6	-2.6	2.6	2.6	-2.7
Delay discount hyperbolic model param	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.0	0.1
Intermittent access intake day 1-15 change	1.8	1.8	1.9	-1.2	1.4	1.4	-1.4	-1.3	1.3
Intermittent access intake escalation	0.9	0.9	1.0	-0.8	1.0	1.0	-1.0	-0.9	1.0
Intermittent access intake escalation 2	0.1	0.1	0.1	0.2	-0.2	-0.2	0.2	0.3	-0.2
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	-0.5	0.3	0.3	-0.2	-0.2	0.5
Intermitt. access day 15 inactive lever presses	1.7	1.8	2.1	-1.3	1.3	1.3	-1.4	-1.4	1.4
Intermitt. access escalation Index	3.4	3.0	4.5	2.1	-1.6	-1.6	1.7	1.6	-1.7
Intermittent access day 1 total infusions	4.0	4.6	5.9	-2.4	2.1	2.1	-2.1	-2.2	2.0
Intermittent access day 15 total infusions	4.5	5.1	6.1	-2.5	2.2	2.2	-2.3	-2.2	2.2
Intermittent access terminal intake (last 3 days)	3.8	4.2	4.6	-2.1	2.0	2.0	-2.1	-2.0	1.9
Intermittent access total infusions	5.5	6.1	7.4	-2.7	2.4	2.4	-2.5	-2.4	2.4
Intermittent access day 1 locomotion	2.5	2.6	3.0	-1.6	1.6	1.6	-1.5	-1.6	1.7
Intermittent access day 15 total locomotion	0.6	0.6	1.2	-1.1	0.7	0.7	-0.6	-0.8	0.7
Intermittent access total locomotion	1.1	1.2	1.8	-1.3	1.1	1.1	-1.0	-1.1	1.1
Intermittent access standard deviation	0.8	0.9	1.6	-1.3	0.9	0.9	-0.8	-0.8	0.9
Left kidney weight	0.6	1.6	2.5	-1.6	1.2	1.2	-1.2	-1.1	1.3
Right kidney weight	0.1	0.2	0.5	0.1	-0.5	-0.5	0.5	0.7	-0.4
Cocaine induced anxiety	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	-0.3	0.1
Post-drug Anxiety	1.3	1.5	1.8	0.9	-1.3	-1.3	1.2	1.2	-1.3
Baseline Anxiety	1.4	1.4	1.5	1.1	-1.2	-1.2	1.2	1.2	-1.2
Tail length	0.1	0.4	0.5	-0.7	0.6	0.6	-0.7	-0.7	0.5
Length with tail	0.1	0.3	0.5	0.5	-0.5	-0.5	0.4	0.7	-0.4
Length without tail	0.1	0.2	0.5	0.4	-0.4	-0.4	0.3	0.7	-0.1
Times rat made contact with spout	0.5	0.6	0.7	-0.7	0.8	0.8	-0.7	-0.8	0.8
Lifetime Intake	6.2	7.1	8.9	-3.0	2.6	2.6	-2.6	-2.6	2.5
Liver weight, left	1.1	1.7	1.9	1.3	-1.3	-1.3	1.4	1.3	-1.3
Liver weight, right	5.6	9.3	10.3	3.2	-3.0	-3.0	3.0	3.2	-2.8
Locomotor activity	0.7	1.0	1.6	1.3	-0.9	-0.9	0.9	1.0	-1.0
Locomotor testing distance	0.4	0.7	1.3	1.2	-0.8	-0.8	0.8	0.8	-0.9
Locomotor testing rearing	0.3	0.5	0.7	-0.3	0.8	0.8	-0.8	-0.6	0.8
Locomotion in novel chamber	0.4	0.5	0.6	0.6	-0.7	-0.7	0.7	0.8	-0.8
Locomotion in novel chamber post-restriction	3.1	3.7	5.1	2.2	-1.9	-1.9	1.9	2.0	-1.7
Fecal boli incidents, locomotor time 1	3.0	3.3	3.6	-1.9	1.8	1.8	-1.8	-1.6	1.9
Change in fecal boli incidents, locomotor task	3.4	3.2	3.4	1.8	-1.8	-1.8	1.8	1.9	-1.8
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.5	-0.7	0.7	0.7	-0.7	-0.6	0.7
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.3	0.0	0.0	-0.1	-0.1	0.0
Total resting periods, locomotor time 1	0.0	0.0	0.2	0.4	0.1	0.1	-0.2	-0.1	0.1
Rest time, locomotor task time 1	0.0	0.0	0.0	0.2	0.1	0.1	-0.0	-0.2	0.1
Distance moved, locomotor task time 1	0.2	0.2	0.2	0.3	-0.4	-0.4	0.4	0.5	-0.4
Vertical activity count, locomotor time 1	0.2	0.2	0.3	0.2	-0.5	-0.5	0.4	0.5	-0.5
Time >=10cm from walls, locomotor time 2	1.8	1.9	2.1	-1.5	1.4	1.4	-1.3	-1.3	1.4
Bouts of movement, locomotor time 2	0.7	0.7	1.1	1.1	-0.8	-0.8	0.7	0.8	-0.8
Total resting periods, locomotor time 2	0.8	0.8	1.2	1.1	-0.9	-0.9	0.8	0.8	-0.8
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1	-0.0	-0.1
Distance moved, locomotor task time 2	0.0	0.1	0.1	-0.3	0.2	0.2	-0.2	-0.2	0.2
Vertical activity count, locomotor time 2	0.4	0.5	0.7	-0.8	0.6	0.6	-0.7	-0.6	0.7
Light reinforcement 1	0.4	0.7	1.2	-0.5	0.9	0.9	-1.1	-0.8	0.8
Light reinforcement 2	1.1	1.5	2.2	-0.9	1.2	1.2	-1.3	-1.2	1.5
Bone: marrow area	0.1	0.1	0.2	-0.3	0.4	0.4	-0.4	-0.3	0.5
Bone: maximum diameter	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.1	0.1	0.0
Bone: maximum force	0.0	0.0	0.0	0.1	-0.1	-0.2	0.1	0.2	-0.1
Bone: maximum moment	0.0	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	-0.1
Mean time between licks in bursts	1.8	2.6	3.5	1.9	-1.6	-1.6	1.6	1.5	-1.5
Mean num. licks in bursts	1.5	1.8	1.9	-1.3	1.4	1.4	-1.3	-1.4	1.4
Cd content in liver	0.4	0.4	0.5	0.7	-0.6	-0.6	0.5	0.7	-0.7
Co content in liver	4.8	5.6	6.7	-2.2	2.4	2.4	-2.4	-2.6	2.2
Cu content in liver	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3	-0.2	0.3
Fe content in liver	0.1	0.1	0.2	-0.4	0.4	0.3	-0.4	-0.2	0.4
K content in liver	2.2	2.2	3.8	2.0	-1.3	-1.4	1.3	1.4	-1.3
Mg content in liver	1.8	1.8	2.2	1.5	-1.3	-1.3	1.2	1.5	-1.2
Mn content in liver	0.2	0.3	0.4	0.6	-0.5	-0.5	0.5	0.5	-0.3
Na content in liver	1.8	1.9	2.5	-0.9	1.4	1.4	-1.4	-1.3	1.6
Rb content in liver	0.5	0.7	1.2	1.1	-0.7	-0.8	0.6	0.9	-0.8
Se content in liver	0.8	1.0	1.4	0.9	-1.0	-1.0	1.0	1.2	-0.9
Sr content in liver	0.1	0.0	0.1	0.3	-0.2	-0.2	0.2	0.1	-0.2
Zn content in liver	1.5	1.7	2.2	1.5	-1.3	-1.3	1.2	1.4	-1.1
Bone: minimum diameter	0.4	0.8	1.2	0.4	-0.9	-1.0	0.8	1.1	-0.9
Time in familiar zone, hab. session 1	0.8	0.8	0.9	0.8	-0.9	-0.9	0.8	1.0	-0.9
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	0.4	-0.5
Total zone transitions, hab. session 1	0.1	0.2	0.2	-0.5	0.4	0.4	-0.4	-0.3	0.3
Total locomotion distance, hab. session 1	0.6	0.9	0.9	-0.9	1.0	1.0	-1.0	-1.0	0.9
Locomotion velocity, hab. session 1	1.2	1.8	1.9	-1.3	1.4	1.4	-1.3	-1.4	1.2
Time in familiar zone, hab. session 2	0.3	0.3	0.3	0.4	-0.6	-0.6	0.5	0.5	-0.5
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.1
Total zone transitions, hab. session 2	0.3	0.3	0.4	0.7	-0.5	-0.6	0.6	0.7	-0.6
Total locomotion distance, hab. session 2	0.3	0.4	0.5	0.7	-0.6	-0.6	0.6	0.5	-0.6
Locomotion velocity, hab. session 2	0.1	0.2	0.3	0.5	-0.4	-0.4	0.4	0.4	-0.4
Novel to familiar place preference ratio	0.5	0.5	1.1	1.1	-0.7	-0.7	0.7	0.7	-0.6
Novelty place preference	0.9	0.9	1.5	1.2	-0.9	-0.9	0.9	0.9	-0.8
Time in novel zone, NPP test	0.8	0.8	1.3	1.2	-0.8	-0.8	0.8	0.9	-0.7
Total zone transitions, NPP test	0.6	0.9	1.0	-0.8	1.0	1.0	-1.0	-0.9	1.0
Total locomotion distance, NPP test	1.0	1.4	1.7	-0.9	1.3	1.3	-1.2	-1.2	1.3
Locomotion velocity, NPP test	1.4	2.0	2.2	-1.2	1.5	1.5	-1.5	-1.4	1.5
Intraocular pressure	4.5	6.2	7.1	2.4	-2.5	-2.5	2.6	2.7	-2.3
Delta distance traveled before/after self-admin	1.7	1.8	2.1	1.4	-1.4	-1.4	1.2	1.5	-1.3
Delta ambulatory time before/after self-admin	0.4	0.4	0.7	0.8	-0.6	-0.6	0.5	0.7	-0.6
Parametrial fat weight	9.5	18.6	19.5	4.1	-4.4	-4.4	4.3	4.3	-4.4
Pavlov. Cond. lever latency	0.5	0.6	0.8	0.9	-0.7	-0.7	0.7	0.6	-0.8
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	0.1	-0.2	-0.3	0.2	0.4	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	0.2	0.2	-0.2	-0.1	0.2
Pavlov. Cond. index score	0.0	0.0	0.1	-0.3	0.2	0.2	-0.2	-0.0	0.3
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.2	0.1	0.1	-0.0	0.1	0.1
Pavlov. Cond. lever contacts	0.4	0.4	0.5	-0.7	0.7	0.7	-0.6	-0.5	0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0	-0.1	-0.0
Pavlov. Cond. intertrial magazine entries	2.2	2.6	3.0	-1.7	1.6	1.6	-1.6	-1.7	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	-0.7	0.7	0.6	-0.6	-0.5	0.7
Pavlov. Cond. response bias	0.9	1.1	1.3	-1.1	1.0	1.0	-1.0	-0.9	1.1
Pavlov. Cond. lever latency	0.8	1.0	1.3	0.7	-1.0	-1.0	1.0	1.2	-1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.3	0.5	-0.1	-0.1	0.1	0.0	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	0.2	0.2	-0.1	-0.3	0.2
Pavlov. Cond. index score	0.3	0.3	0.5	-0.3	0.6	0.6	-0.6	-0.7	0.6
Pavlov. Cond. latency score	0.3	0.4	0.5	-0.2	0.6	0.6	-0.6	-0.7	0.7
Pavlov. Cond. lever contacts	0.2	0.3	0.4	-0.3	0.5	0.5	-0.5	-0.6	0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.6	0.3	0.3	-0.3	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	2.5	3.3	3.5	1.6	-1.8	-1.8	1.8	1.8	-1.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.0	0.3	0.3	-0.3	-0.4	0.3
Pavlov. Cond. response bias	0.3	0.4	0.7	-0.4	0.7	0.7	-0.7	-0.8	0.7
Time in closed arm before self-admin	0.1	0.1	0.2	0.4	-0.4	-0.4	0.4	0.5	-0.1
Time in closed arm after self-admin	0.7	0.7	0.9	0.9	-0.8	-0.8	0.9	1.0	-0.7
Time in open arm before self-admin	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.1	0.0	-0.2
Time in open arm after self-admin	0.3	0.3	0.8	-0.9	0.5	0.5	-0.4	-0.5	0.3
Bone: periosteal estimation	0.1	0.2	0.4	-0.6	0.4	0.4	-0.4	-0.2	0.4
Bone: periosteal perimeter	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.0	0.2	-0.1
Bone: post-yield work	1.9	2.6	3.2	-1.8	1.6	1.6	-1.6	-1.6	1.5
Progressive ratio test 1 active lever presses	3.3	3.4	4.2	-2.1	1.8	1.8	-1.8	-1.9	1.7
Progressive ratio test 1 breakpoint	2.5	2.6	3.4	-1.8	1.6	1.6	-1.6	-1.6	1.4
Progressive ratio test 1 inactive lever presses	5.5	6.0	6.5	-2.5	2.4	2.4	-2.4	-2.5	2.4
Progressive ratio test 2 active lever presses	2.5	2.7	3.2	-1.8	1.6	1.6	-1.7	-1.5	1.6
Progressive ratio test 2 breakpoint	2.6	2.9	3.4	-1.8	1.7	1.6	-1.8	-1.6	1.7
Progressive ratio test 2 inactive lever presses	3.3	3.8	4.4	-2.1	1.9	1.9	-2.0	-1.9	1.9
Incentive Sensitization - Responses	1.5	1.5	2.1	-1.1	1.2	1.2	-1.4	-1.0	1.3
Incentive Sensitization - Breakpoint	1.0	1.0	1.4	-0.8	1.0	1.0	-1.2	-0.8	1.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.5	-0.3	-0.4	0.2	0.5	-0.2
Progressive ratio	0.2	0.2	0.3	-0.3	0.5	0.5	-0.4	-0.5	0.6
Food seeking constrained by brief footshock	14.9	18.4	19.8	-4.1	4.3	4.3	-4.4	-4.1	4.4
Seeking ratio, punishment vs. effort	1.5	1.8	2.4	-1.5	1.3	1.3	-1.4	-1.2	1.2
Retroperitoneal fat weight	30.0	98.5	101.6	9.6	-10.0	-10.0	10.0	9.8	-10.1
Reaction time number correct	0.2	0.2	0.6	-0.7	0.4	0.4	-0.4	-0.5	0.4
Reaction time mean minus median	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.0	-0.2	-0.2
Reaction time mean minus median AUC	0.1	0.1	0.3	0.3	-0.3	-0.3	0.3	0.1	-0.5
Reaction time num false alarms	1.8	2.5	3.3	1.8	-1.5	-1.6	1.4	1.7	-1.5
Reaction time num false alarms AUC	1.9	2.6	3.6	1.9	-1.6	-1.6	1.4	1.6	-1.5
Reaction time trials correct on left	0.2	0.2	0.6	-0.7	0.4	0.4	-0.4	-0.5	0.4
Reaction time trials on left	0.2	0.2	0.5	-0.7	0.4	0.4	-0.3	-0.4	0.4
Reaction time mean	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.2	0.0	-0.3
Reaction time mean AUC	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	-0.1	-0.2
Median of all reaction times	0.0	0.0	0.0	-0.2	-0.0	-0.0	0.0	-0.0	-0.1
Reaction time omissions	0.2	0.3	0.6	0.4	-0.5	-0.5	0.5	0.4	-0.8
Reaction time false alarm rate	2.4	3.3	4.8	2.2	-1.8	-1.8	1.6	1.8	-1.7
Reaction time premature initiation rate	0.2	0.3	0.7	0.8	-0.4	-0.4	0.4	0.4	-0.5
Reaction time premature initiations	0.0	0.0	0.1	0.3	-0.2	-0.2	0.2	0.1	-0.2
Std. dev. reaction times	0.2	0.3	0.5	0.3	-0.5	-0.5	0.6	0.3	-0.7
Reaction time trials completed	0.2	0.2	0.5	-0.7	0.4	0.4	-0.3	-0.4	0.4
Reaction time trials AUC	0.2	0.3	0.5	-0.7	0.5	0.5	-0.4	-0.5	0.4
Run reversals in cocaine runway, females	0.4	0.4	0.5	-0.6	0.6	0.6	-0.5	-0.7	0.7
Run reversals in cocaine runway, males	1.1	1.1	1.5	-1.2	1.1	1.1	-1.0	-1.0	0.9
Latency to leave start box in cocaine runway	0.4	0.4	0.7	-0.7	0.6	0.6	-0.7	-0.8	0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.2	0.3	0.3	-0.4	-0.4	0.1
Latency to leave start box in cocaine runway, M	1.9	1.8	2.2	-1.5	1.3	1.4	-1.2	-1.4	1.2
Std. dev. time between licks in bursts	1.0	1.2	2.1	1.4	-1.0	-1.0	1.0	1.0	-0.9
Total sessions with >9 infusions	7.0	7.7	8.0	-2.8	2.8	2.8	-2.8	-2.7	2.8
Short access day 1 total inactive lever presses	3.0	3.3	5.4	-2.3	1.7	1.8	-1.6	-1.8	1.7
Short access day 10 total inactive lever presses	0.1	0.1	0.1	0.4	-0.2	-0.2	0.3	0.3	-0.2
Short access day 1 total infusions	5.2	5.5	7.4	-2.7	2.3	2.3	-2.3	-2.4	2.1
Short access day 10 total infusions	7.1	7.9	9.9	-3.2	2.7	2.7	-2.7	-2.8	2.7
Short access total infusions	5.5	6.2	8.0	-2.8	2.4	2.4	-2.4	-2.5	2.3
Short access day 1 locomotion	5.6	6.0	6.9	-2.5	2.5	2.5	-2.3	-2.6	2.3
Short access day 10 total locomotion	1.3	1.5	2.1	-0.9	1.3	1.3	-1.2	-1.3	1.5
Short access total locomotion	2.4	2.5	2.8	-1.5	1.6	1.6	-1.4	-1.7	1.7
One hour access (0.3 mA shock)	2.5	2.9	5.2	-2.3	1.6	1.6	-1.6	-1.5	1.5
Compulsive drug intake	3.8	3.9	4.5	1.8	-1.9	-1.9	2.1	2.0	-2.0
One hour access (shock baseline)	6.8	7.8	9.6	-3.1	2.7	2.7	-2.8	-2.6	2.8
Social response proportion	0.2	0.2	0.6	-0.8	0.4	0.4	-0.3	-0.4	0.1
Social responses	0.1	0.1	0.2	0.1	-0.4	-0.4	0.4	0.4	-0.4
Social time	0.1	0.2	0.5	-0.7	0.3	0.3	-0.3	-0.3	0.2
Soleus weight	2.8	8.1	12.4	-3.5	2.7	2.7	-2.7	-2.7	2.7
Bone: stiffness	0.1	0.2	0.3	0.3	-0.4	-0.4	0.4	0.5	-0.4
Tibialis anterior weight	0.7	2.6	2.7	-1.7	1.6	1.6	-1.6	-1.6	1.6
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.4	1.2	-0.7	-0.7	0.5	0.8	-0.6
Time to tail flick, vehicle, after self-admin	6.0	6.4	7.5	2.2	-2.6	-2.5	2.7	2.3	-2.7
Time to tail flick, test, before self-admin	1.1	1.1	1.6	-0.6	1.1	1.1	-1.1	-1.1	1.3
Time to tail flick, test, after self-admin	1.0	1.0	1.1	-1.0	1.0	1.0	-1.0	-0.9	1.1
Delta time to tail flick, vehicle, before/after SA	2.0	2.0	2.8	0.9	-1.5	-1.4	1.7	1.2	-1.6
Delta time to tail flick, test, before/after SA	1.8	1.6	1.9	-1.4	1.2	1.2	-1.3	-1.2	1.2
Tibia length	0.7	2.0	2.5	1.1	-1.4	-1.4	1.3	1.5	-1.6
Ambulatory time before self-admin	0.1	0.1	0.1	-0.3	0.3	0.3	-0.2	-0.4	0.4
Ambulatory time after self-admin	0.1	0.1	0.2	0.4	-0.3	-0.3	0.2	0.4	-0.2
Bone: tissue strength	0.5	0.5	0.7	0.5	-0.7	-0.7	0.8	0.6	-0.8
Total heroin consumption	1.3	1.5	1.9	-1.0	1.3	1.3	-1.4	-1.2	1.2
Bone: trabecular number	3.5	5.4	7.6	-2.8	2.2	2.2	-2.3	-2.1	2.3
Bone: trabecular spacing	1.0	1.3	2.2	1.5	-1.0	-1.0	1.0	1.0	-1.1
Bone: trabecular thickness	0.5	0.6	0.7	-0.7	0.7	0.7	-0.7	-0.7	0.8
Bone: trabecular tissue density	0.1	0.2	0.3	-0.3	0.4	0.4	-0.3	-0.5	0.3
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1	0.2
Number of responses in last shaping day	2.7	2.8	3.1	-1.7	1.7	1.6	-1.8	-1.6	1.7