Garem2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Garem2	0.04	0.04	1.3e-03	0.03	0.02	0.02	0.02	8.3e-04	1.3e-03	1.1e-03	1.2e-03
2	Liver	gene expression	Garem2	0.04	0.04	8.2e-04	0.02	0.02	0.01	0.02	2.9e-03	1.8e-03	8.5e-03	3.5e-03
3	Brain	mRNA stability	Garem2	0.05	0.04	7.8e-05	0.04	0.04	0.02	0.04	1.2e-04	1.9e-04	2.9e-03	2.4e-04
4	BLA	mRNA stability	Garem2	0.05	0.06	9.4e-03	0.02	0.02	0.02	0.02	2.6e-02	2.7e-02	3.1e-02	3.7e-02
5	IC	mRNA stability	Garem2	0.06	0.06	9.7e-03	0.02	0.02	-0	0.01	4.8e-02	6.6e-02	3.5e-01	1.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.1	3.7	4.0	2.0	2.0	-1.9	-1.8	-2.0
Area under the delay curve	0.0	0.0	0.1	-0.0	0.1	-0.2	-0.3	-0.1
BMI with tail	1.9	6.5	7.7	-2.5	-2.6	2.8	2.4	2.5
BMI without tail	2.0	6.0	6.7	-2.5	-2.5	2.6	2.3	2.5
Body weight	2.1	9.4	10.5	-3.1	-3.1	2.9	3.2	2.9
Weight adjusted by age	0.0	0.0	0.1	-0.3	-0.2	0.0	0.3	-0.0
Bone surface	0.3	0.5	0.6	0.7	0.7	-0.7	-0.6	-0.8
Bone volume	0.9	1.6	1.9	1.3	1.3	-1.3	-1.0	-1.4
Breakpoint value in progressive ratio session	0.6	0.8	1.1	0.7	0.9	-1.0	-0.8	-0.9
Number of licking bursts	0.9	1.5	1.9	-1.4	-1.3	1.3	0.9	1.3
Context. condit. distance diff. score	0.3	0.4	0.6	0.6	0.6	-0.7	-0.6	-0.5
Locomotion velocity, session 1	0.5	0.5	0.7	-0.8	-0.8	0.8	0.3	0.7
Locomotion distance, session 1	0.3	0.4	0.4	0.6	0.6	-0.6	-0.6	-0.6
Locomotion velocity, session 2	0.0	0.0	0.1	-0.1	-0.2	0.2	0.3	0.2
Locomotion distance, session 2	0.1	0.1	0.2	-0.3	-0.3	0.3	0.5	0.3
Locomotion velocity, session 3	0.1	0.1	0.2	0.2	0.2	-0.2	-0.4	-0.1
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	-0.2	0.2	0.1	0.2
Stereotopy head waving bouts, day 3	2.0	2.3	2.6	1.5	1.6	-1.6	-1.3	-1.5
Stereotopy head waving duration, day 3	0.5	0.6	0.8	0.8	0.8	-0.9	-0.7	-0.7
Locomotion velocity, session 7	0.0	0.0	0.1	-0.1	-0.1	0.0	0.2	0.0
Locomotion distance, session 7	0.9	1.1	1.4	-1.1	-1.0	1.0	1.2	0.9
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3	0.0
Stereotopy head waving duration, day 7	0.4	0.5	0.6	0.7	0.7	-0.6	-0.8	-0.7
Locomotion velocity, session 8	0.5	0.6	0.9	0.8	0.8	-0.7	-0.9	-0.7
Locomotion distance, session 8	0.3	0.4	0.5	0.7	0.6	-0.7	-0.7	-0.6
Degree of sensitization distance	0.9	1.0	1.6	-0.9	-0.9	0.9	1.2	0.8
Degree of sensitization stereotypy	0.3	0.4	0.5	-0.6	-0.6	0.6	0.7	0.6
Conditioned locomotion	3.5	4.0	5.3	2.0	1.9	-1.8	-2.3	-1.9
Cocaine response after cond. corrected	0.1	0.2	0.2	0.4	0.4	-0.4	-0.4	-0.4
Cocaine response after cond. not corrected	0.7	0.8	0.9	0.9	0.9	-0.9	-0.9	-0.8
Cocaine response before conditioning	2.6	3.1	3.6	1.8	1.7	-1.7	-1.9	-1.6
Saline control response	1.1	1.4	1.6	1.2	1.2	-1.2	-0.9	-1.3
Bone: connectivity density	1.3	2.0	2.2	1.4	1.4	-1.4	-1.3	-1.5
Bone: cortical apparent density	0.1	0.1	0.2	0.3	0.2	-0.2	-0.4	-0.1
Bone: cortical area	0.0	0.1	0.2	-0.2	-0.2	0.1	0.4	0.2
Bone: cortical porosity	3.1	3.4	4.1	1.8	1.9	-1.9	-1.7	-2.0
Bone: cortical porosity	2.8	3.0	3.6	1.7	1.8	-1.7	-1.6	-1.9
Bone: cortical thickness	0.2	0.4	0.4	-0.6	-0.6	0.6	0.6	0.7
Bone: cortical thickness	0.3	0.3	0.5	0.5	0.5	-0.6	-0.7	-0.6
Bone: cortical tissue density	0.0	0.0	0.1	0.2	0.1	-0.1	-0.3	-0.0
Condit. Reinf. active minus inactive responses	2.0	2.3	2.9	-1.4	-1.5	1.5	1.5	1.7
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.4	-1.2	-1.4	1.3	1.3	1.6
Condit. Reinf. active responses	0.1	0.2	0.3	-0.3	-0.4	0.4	0.2	0.6
Condit. Reinf. inactive responses	0.9	1.1	1.2	1.0	1.1	-1.0	-1.0	-1.1
Incentive salience index mean	0.3	0.3	0.5	-0.4	-0.5	0.5	0.7	0.6
Condit. Reinf. lever presses	0.7	1.0	1.2	1.1	1.1	-1.1	-0.6	-1.1
Condit. Reinf. active minus inactive responses	1.1	1.5	2.8	1.0	1.1	-1.0	-1.7	-1.1
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.2	0.7	0.7	-0.7	-1.1	-0.8
Condit. Reinf. active responses	0.6	0.8	1.6	0.8	0.8	-0.8	-1.3	-0.8
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.4	0.4	-0.4	-0.5	-0.3
Condit. Reinf. lever presses	1.1	1.5	2.1	1.2	1.2	-1.1	-1.4	-1.2
Condit. Reinf. lever reinforcers received	0.6	0.8	1.5	0.8	0.8	-0.8	-1.2	-0.8
Conditioned reinforcement - actives	3.9	6.7	9.0	3.0	2.6	-2.4	-2.7	-2.2
Conditioned reinforcement - inactives	4.8	7.0	7.4	2.6	2.6	-2.7	-2.7	-2.6
Conditioned locomotion	1.8	2.3	2.5	1.6	1.6	-1.5	-1.4	-1.6
Patch foraging indifference point 0 sec	0.7	1.4	2.7	-1.2	-1.0	1.0	1.6	0.8
Patch foraging indifference point AUC	0.0	0.1	0.2	-0.3	-0.1	0.1	-0.4	-0.2
Delay disc. indifference point, 0s delay	0.8	0.9	1.2	-1.1	-0.9	1.1	0.8	0.6
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.2	-0.1	-0.2	0.0	0.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.4	-0.3	0.2	0.3	0.3
Delay disc. indifference point, 24s delay	2.1	2.3	2.5	1.6	1.5	-1.6	-1.3	-1.6
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.4	-0.3	0.3	0.1	0.2
Delay disc. indifference point, 8s delay	0.0	0.1	0.2	0.2	0.2	-0.2	-0.4	-0.2
Indifference point function ln k	1.2	2.0	2.6	1.5	1.5	-1.5	-0.9	-1.6
Indifference point function log k	1.2	2.0	2.6	1.5	1.5	-1.5	-0.9	-1.6
Patch foraging total patch changes 0 sec	0.8	1.5	2.9	-1.3	-1.1	1.0	1.7	0.8
Patch foraging total patch changes 12 sec	1.3	1.7	2.5	-1.6	-1.2	1.1	1.5	1.0
Patch foraging total patch changes 18 sec	1.2	1.8	2.5	-1.5	-1.3	1.2	1.6	1.0
Patch foraging total patch changes 24 sec	1.2	2.0	2.7	-1.7	-1.4	1.3	1.5	1.2
Patch foraging total patch changes 6 sec	2.0	3.0	4.2	-2.1	-1.7	1.7	1.7	1.5
Patch foraging time to switch 0 sec	0.3	0.5	0.8	-0.6	-0.7	0.6	0.8	0.9
Patch foraging water rate 0 sec	0.7	1.4	1.9	1.2	1.2	-1.3	-0.9	-1.4
Patch foraging water rate 12 sec	0.0	0.1	0.1	-0.2	-0.3	0.2	0.3	0.3
Patch foraging water rate 18 sec	0.7	1.0	1.2	1.1	1.1	-1.1	-0.8	-1.0
Patch foraging water rate 24 sec	0.1	0.2	0.5	-0.3	-0.4	0.4	0.7	0.3
Patch foraging water rate 6 sec	0.1	0.2	0.2	0.4	0.4	-0.5	-0.3	-0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	-0.3	-0.3	0.2	0.4	0.2
Distance traveled before self-admin	0.1	0.2	0.5	0.5	0.4	-0.1	-0.7	-0.2
Distance traveled after self-admin	0.9	1.1	1.4	-1.1	-1.0	1.1	1.2	0.9
Extensor digitorum longus weight	2.2	8.8	9.9	2.9	2.9	-2.9	-3.1	-2.9
Bone: elastic displacement	1.5	1.8	2.1	1.4	1.3	-1.2	-1.4	-1.2
Bone: elastic work	0.5	0.6	0.9	0.8	0.8	-0.8	-1.0	-0.6
Bone: endosteal estimation	0.1	0.2	0.2	0.4	0.4	-0.4	-0.2	-0.5
Bone: endosteal perimeter	0.0	0.0	0.0	-0.1	0.0	-0.1	0.1	-0.1
Epididymis fat weight	15.9	54.6	56.8	-7.5	-7.5	7.4	7.2	7.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	-0.6	-0.3	0.0	0.4	0.1
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.2	-0.0	0.1	0.0	0.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.3	-0.3	0.0	0.4	0.1
Delay discount exponential model param	0.1	0.1	0.3	-0.2	-0.3	0.5	0.5	0.3
Extinction: sum of active levers before priming	0.5	0.6	1.0	0.7	0.8	-1.0	-0.3	-0.8
Active lever presses in extinction session 6	2.0	2.0	2.4	1.3	1.4	-1.5	-1.3	-1.6
Bone: final force	0.0	0.0	0.0	-0.2	-0.1	0.1	0.2	0.1
Bone: final moment	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2	0.1
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.5	-0.3	0.3	0.0	0.2
Glucose	0.8	1.3	1.6	-1.3	-1.2	1.2	1.0	1.1
Heart weight	1.2	1.8	3.2	-1.0	-1.3	1.3	1.8	1.3
Delay discount hyperbolic model param	0.0	0.0	0.1	0.0	-0.1	0.2	0.3	0.1
Intermittent access intake day 1-15 change	0.4	0.8	1.0	1.0	1.0	-0.9	-0.9	-0.8
Intermittent access intake escalation	0.2	0.3	0.4	0.6	0.6	-0.5	-0.6	-0.5
Intermittent access intake escalation 2	0.0	0.0	0.1	0.3	0.1	-0.0	-0.1	0.0
Intermitt. access day 1 inactive lever presses	0.4	1.4	1.7	1.1	1.2	-1.2	-1.1	-1.3
Intermitt. access day 15 inactive lever presses	0.9	1.9	2.5	1.1	1.3	-1.4	-1.6	-1.3
Intermitt. access escalation Index	4.3	6.0	6.8	-2.6	-2.5	2.4	2.5	2.3
Intermittent access day 1 total infusions	2.5	4.1	4.9	2.2	2.0	-2.1	-2.0	-1.8
Intermittent access day 15 total infusions	2.2	3.4	4.0	2.0	1.9	-1.9	-1.7	-1.7
Intermittent access terminal intake (last 3 days)	3.4	4.5	5.1	2.2	2.1	-2.2	-2.0	-2.0
Intermittent access total infusions	4.6	5.4	6.2	2.5	2.3	-2.4	-2.2	-2.2
Intermittent access day 1 locomotion	2.3	2.9	3.4	1.8	1.8	-1.7	-1.3	-1.8
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.5	0.3	-0.2	-0.4	-0.1
Intermittent access total locomotion	1.2	1.4	2.0	1.4	1.3	-1.2	-0.9	-1.2
Intermittent access standard deviation	0.9	2.0	2.7	1.7	1.5	-1.4	-1.2	-1.3
Left kidney weight	0.1	0.7	1.0	0.7	0.8	-1.0	-0.3	-1.0
Right kidney weight	0.0	0.2	0.5	-0.2	-0.3	0.3	0.7	0.3
Cocaine induced anxiety	0.0	0.1	0.1	0.1	0.2	-0.3	-0.3	-0.3
Post-drug Anxiety	1.5	1.6	2.0	-1.4	-1.3	1.2	1.2	1.2
Baseline Anxiety	3.4	3.9	4.2	-2.0	-2.0	2.0	1.9	2.0
Tail length	0.0	0.0	0.1	-0.1	0.0	-0.3	0.3	-0.1
Length with tail	0.1	0.4	1.1	-0.7	-0.6	0.2	1.1	0.5
Length without tail	0.0	0.1	0.4	-0.3	-0.1	-0.2	0.7	-0.2
Times rat made contact with spout	0.5	0.6	0.7	0.7	0.8	-0.7	-0.8	-0.8
Lifetime Intake	5.0	6.1	7.3	2.7	2.5	-2.6	-2.3	-2.3
Liver weight, left	1.8	3.0	3.2	-1.6	-1.7	1.7	1.7	1.8
Liver weight, right	3.2	5.6	7.4	-2.2	-2.3	2.3	2.7	2.2
Locomotor activity	0.7	1.0	1.4	-1.0	-0.9	1.0	1.2	0.9
Locomotor testing distance	0.3	0.5	0.6	-0.7	-0.7	0.7	0.8	0.8
Locomotor testing rearing	0.2	0.4	0.5	0.6	0.7	-0.7	-0.3	-0.7
Locomotion in novel chamber	0.0	0.1	0.1	-0.3	-0.2	0.3	0.0	0.2
Locomotion in novel chamber post-restriction	2.3	3.7	4.4	-2.1	-2.0	1.8	1.9	1.9
Fecal boli incidents, locomotor time 1	1.8	2.5	3.3	1.5	1.7	-1.7	-1.2	-1.8
Change in fecal boli incidents, locomotor task	3.4	3.3	3.8	-2.0	-1.9	1.6	1.9	1.8
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.6	0.5	0.6	-0.6	-0.8	-0.7
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.1	-0.1	0.2	0.2	0.0
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.2	-0.1	0.2	0.1	0.0
Rest time, locomotor task time 1	0.2	0.3	0.6	-0.5	-0.5	0.8	0.4	0.5
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.2	-0.3	0.1	0.1	0.3
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	0.0	-0.1	0.2
Time >=10cm from walls, locomotor time 2	1.3	2.0	2.4	1.2	1.4	-1.3	-1.6	-1.5
Bouts of movement, locomotor time 2	0.3	0.5	0.6	-0.7	-0.7	0.6	0.8	0.7
Total resting periods, locomotor time 2	0.3	0.6	0.7	-0.8	-0.8	0.7	0.8	0.7
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	-0.0	0.3	-0.1	0.0
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.1	0.1	0.0	-0.2	-0.1
Vertical activity count, locomotor time 2	0.1	0.2	0.2	0.2	0.4	-0.4	-0.5	-0.4
Light reinforcement 1	0.3	0.7	1.2	0.8	0.9	-1.1	-0.1	-0.9
Light reinforcement 2	0.8	1.3	1.7	0.9	1.1	-1.2	-0.9	-1.3
Bone: marrow area	0.1	0.2	0.2	0.4	0.4	-0.4	-0.2	-0.5
Bone: maximum diameter	0.0	0.0	0.1	-0.0	0.0	-0.0	0.3	-0.0
Bone: maximum force	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1
Bone: maximum moment	0.0	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.1
Mean time between licks in bursts	0.8	1.9	2.2	-1.5	-1.4	1.4	1.3	1.3
Mean num. licks in bursts	1.1	1.8	2.1	1.4	1.4	-1.4	-1.0	-1.4
Cd content in liver	0.1	0.1	0.1	0.1	-0.2	0.1	0.3	0.4
Co content in liver	5.3	6.1	6.5	2.5	2.5	-2.6	-2.5	-2.3
Cu content in liver	0.4	0.5	0.6	0.7	0.7	-0.7	-0.8	-0.7
Fe content in liver	1.8	2.2	2.4	1.5	1.5	-1.5	-1.4	-1.5
K content in liver	0.2	0.1	0.2	-0.4	-0.4	0.3	0.5	0.3
Mg content in liver	0.1	0.1	0.4	-0.1	-0.0	-0.1	0.7	-0.1
Mn content in liver	0.9	1.0	2.0	-1.0	-0.9	0.8	1.4	0.7
Na content in liver	2.3	2.5	2.7	1.5	1.6	-1.6	-1.7	-1.6
Rb content in liver	0.1	0.2	0.5	-0.4	-0.3	0.2	0.7	0.3
Se content in liver	0.1	0.2	0.3	-0.5	-0.4	0.4	0.6	0.2
Sr content in liver	0.2	0.1	0.4	0.3	0.3	-0.3	-0.7	-0.2
Zn content in liver	0.5	0.6	0.9	-0.9	-0.7	0.6	1.0	0.6
Bone: minimum diameter	0.5	1.0	1.5	-1.0	-0.9	0.8	1.2	0.9
Time in familiar zone, hab. session 1	0.8	0.8	1.3	-0.8	-0.8	0.8	1.1	0.8
Time in novel zone, hab. session 1	0.3	0.3	0.3	-0.5	-0.5	0.5	0.5	0.5
Total zone transitions, hab. session 1	0.1	0.2	0.3	0.5	0.4	-0.4	-0.3	-0.3
Total locomotion distance, hab. session 1	0.6	0.8	1.1	1.0	1.0	-1.0	-0.6	-0.9
Locomotion velocity, hab. session 1	1.2	1.8	2.0	1.4	1.4	-1.4	-1.2	-1.3
Time in familiar zone, hab. session 2	0.3	0.4	0.5	-0.7	-0.6	0.5	0.7	0.5
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.0	-0.1	0.2	0.1	0.1
Total zone transitions, hab. session 2	0.2	0.3	0.6	-0.4	-0.5	0.5	0.8	0.5
Total locomotion distance, hab. session 2	0.3	0.3	0.4	-0.6	-0.6	0.6	0.6	0.6
Locomotion velocity, hab. session 2	0.1	0.2	0.2	-0.4	-0.4	0.4	0.4	0.4
Novel to familiar place preference ratio	0.5	0.6	1.0	-0.7	-0.7	0.7	1.0	0.5
Novelty place preference	0.9	0.9	1.5	-0.9	-0.9	1.0	1.2	0.8
Time in novel zone, NPP test	0.8	0.9	1.6	-0.9	-0.9	0.9	1.2	0.7
Total zone transitions, NPP test	0.8	1.2	1.4	1.2	1.1	-1.1	-1.0	-1.0
Total locomotion distance, NPP test	1.1	1.5	1.7	1.3	1.3	-1.3	-1.1	-1.3
Locomotion velocity, NPP test	1.5	2.2	2.3	1.5	1.5	-1.5	-1.3	-1.5
Intraocular pressure	4.7	6.7	7.9	-2.5	-2.5	2.7	2.8	2.5
Delta distance traveled before/after self-admin	2.5	2.7	3.5	-1.9	-1.6	1.5	1.8	1.4
Delta ambulatory time before/after self-admin	0.6	0.8	1.2	-1.1	-0.8	0.7	1.1	0.6
Parametrial fat weight	18.3	43.1	46.8	-6.6	-6.7	6.5	6.1	6.8
Pavlov. Cond. lever latency	0.5	0.6	0.7	-0.8	-0.8	0.8	0.7	0.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	0.2	-0.3	-0.3	-0.2
Pavlov. Cond. index score	0.0	0.1	0.1	0.3	0.3	-0.3	-0.1	-0.3
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	0.1	-0.1	0.0	-0.2
Pavlov. Cond. lever contacts	0.5	0.6	0.7	0.8	0.8	-0.7	-0.6	-0.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	0.1
Pavlov. Cond. intertrial magazine entries	2.1	2.5	2.7	1.6	1.6	-1.6	-1.6	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.7	0.6	-0.6	-0.6	-0.7
Pavlov. Cond. response bias	0.7	0.9	0.9	0.9	0.9	-1.0	-0.9	-1.0
Pavlov. Cond. lever latency	0.6	0.9	1.4	-0.8	-0.9	0.8	1.2	0.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.3	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	0.1	0.2	-0.1	-0.7	-0.3
Pavlov. Cond. index score	0.3	0.4	0.9	0.4	0.6	-0.5	-1.0	-0.6
Pavlov. Cond. latency score	0.3	0.5	1.0	0.5	0.6	-0.5	-1.0	-0.7
Pavlov. Cond. lever contacts	0.4	0.5	0.8	0.6	0.7	-0.6	-0.9	-0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.5	0.3	-0.4	0.2	-0.3
Pavlov. Cond. intertrial magazine entries	2.5	3.7	5.3	-1.8	-1.9	1.7	2.3	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.1	0.2	-0.2	-0.7	-0.3
Pavlov. Cond. response bias	0.6	0.8	1.6	0.7	0.8	-0.7	-1.3	-0.8
Time in closed arm before self-admin	0.3	0.4	0.8	-0.4	-0.6	0.9	0.9	0.3
Time in closed arm after self-admin	0.9	1.0	1.2	-1.0	-1.0	1.1	1.1	0.8
Time in open arm before self-admin	0.0	0.0	0.1	-0.3	0.0	-0.3	-0.2	0.1
Time in open arm after self-admin	0.2	0.2	0.4	0.6	0.5	-0.4	-0.6	-0.3
Bone: periosteal estimation	0.1	0.2	0.3	0.4	0.5	-0.5	-0.1	-0.5
Bone: periosteal perimeter	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	-0.1
Bone: post-yield work	1.7	2.6	2.8	1.6	1.6	-1.7	-1.5	-1.6
Progressive ratio test 1 active lever presses	2.9	3.5	4.6	2.2	1.9	-2.0	-1.5	-1.7
Progressive ratio test 1 breakpoint	3.0	3.6	4.7	2.2	2.0	-2.0	-1.5	-1.7
Progressive ratio test 1 inactive lever presses	4.7	6.8	7.2	2.7	2.6	-2.6	-2.7	-2.5
Progressive ratio test 2 active lever presses	3.2	3.7	4.2	2.0	2.0	-2.0	-1.7	-1.8
Progressive ratio test 2 breakpoint	3.0	3.4	3.9	2.0	1.9	-2.0	-1.6	-1.7
Progressive ratio test 2 inactive lever presses	2.7	4.5	5.0	2.2	2.1	-2.2	-2.0	-2.0
Incentive Sensitization - Responses	1.8	2.5	3.2	1.5	1.6	-1.8	-1.4	-1.7
Incentive Sensitization - Breakpoint	1.5	1.9	2.5	1.2	1.4	-1.6	-1.2	-1.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.7	-0.4	-0.1	0.6	0.3
Progressive ratio	0.0	0.0	0.1	-0.1	-0.2	0.1	0.4	0.1
Food seeking constrained by brief footshock	12.5	15.3	17.9	3.8	4.1	-4.2	-3.2	-4.2
Seeking ratio, punishment vs. effort	1.4	2.0	2.3	1.4	1.5	-1.4	-1.4	-1.5
Retroperitoneal fat weight	33.2	141.6	145.4	-12.0	-12.1	11.8	11.6	12.0
Reaction time number correct	0.1	0.2	0.3	0.6	0.5	-0.4	-0.4	-0.5
Reaction time mean minus median	0.0	0.1	0.4	-0.1	-0.1	0.2	-0.6	0.3
Reaction time mean minus median AUC	0.1	0.2	0.3	-0.4	-0.4	0.4	-0.1	0.6
Reaction time num false alarms	2.0	2.8	4.1	-1.7	-1.6	1.5	2.0	1.5
Reaction time num false alarms AUC	1.9	3.0	4.3	-1.7	-1.7	1.6	2.1	1.5
Reaction time trials correct on left	0.1	0.2	0.3	0.6	0.5	-0.4	-0.4	-0.5
Reaction time trials on left	0.1	0.2	0.3	0.5	0.4	-0.4	-0.4	-0.4
Reaction time mean	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.2	0.3
Reaction time mean AUC	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.2	0.2
Median of all reaction times	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.1	0.2
Reaction time omissions	0.2	0.2	0.5	-0.4	-0.5	0.4	0.4	0.7
Reaction time false alarm rate	2.5	3.4	4.3	-1.9	-1.8	1.7	2.1	1.7
Reaction time premature initiation rate	0.1	0.2	0.2	-0.5	-0.4	0.4	0.4	0.4
Reaction time premature initiations	0.0	0.0	0.1	-0.2	-0.1	0.1	0.2	0.1
Std. dev. reaction times	0.2	0.3	0.6	-0.5	-0.5	0.7	-0.2	0.7
Reaction time trials completed	0.1	0.2	0.3	0.5	0.4	-0.4	-0.4	-0.4
Reaction time trials AUC	0.1	0.3	0.4	0.6	0.5	-0.5	-0.5	-0.5
Run reversals in cocaine runway, females	0.7	0.7	1.0	0.9	0.8	-0.7	-1.0	-0.7
Run reversals in cocaine runway, males	0.8	0.8	0.9	0.9	1.0	-0.8	-0.8	-0.9
Latency to leave start box in cocaine runway	0.8	1.0	2.1	0.9	0.8	-1.0	-1.4	-0.6
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.3	0.2	-0.4	-0.7	-0.1
Latency to leave start box in cocaine runway, M	1.0	0.9	1.7	0.9	0.9	-0.8	-1.3	-0.8
Std. dev. time between licks in bursts	0.9	1.3	1.6	-1.2	-1.1	1.1	1.3	0.9
Total sessions with >9 infusions	2.4	3.0	4.3	2.1	1.8	-1.8	-1.3	-1.5
Short access day 1 total inactive lever presses	5.0	6.6	8.4	2.9	2.6	-2.5	-2.5	-2.3
Short access day 10 total inactive lever presses	0.5	1.1	1.7	1.0	1.1	-0.8	-1.3	-1.1
Short access day 1 total infusions	4.2	5.6	6.5	2.6	2.3	-2.5	-2.4	-2.0
Short access day 10 total infusions	4.3	5.5	6.9	2.6	2.4	-2.4	-2.0	-2.2
Short access total infusions	2.9	3.7	4.7	2.2	1.9	-2.1	-1.7	-1.7
Short access day 1 locomotion	2.5	3.1	3.9	2.0	1.8	-1.6	-1.9	-1.5
Short access day 10 total locomotion	1.0	1.8	2.3	1.4	1.5	-1.3	-0.9	-1.5
Short access total locomotion	1.0	1.3	1.6	1.3	1.2	-1.1	-0.7	-1.2
One hour access (0.3 mA shock)	3.1	3.6	5.1	2.3	1.9	-1.8	-2.0	-1.6
Compulsive drug intake	2.5	3.0	3.5	-1.5	-1.7	1.9	1.8	1.7
One hour access (shock baseline)	4.7	7.2	7.6	2.7	2.7	-2.8	-2.7	-2.6
Social response proportion	0.0	0.1	0.2	0.4	0.2	-0.2	-0.1	-0.0
Social responses	0.2	0.3	0.5	-0.3	-0.5	0.4	0.7	0.6
Social time	0.0	0.0	0.1	0.3	0.2	-0.3	0.2	-0.0
Soleus weight	3.0	8.8	10.5	3.0	2.9	-2.9	-3.2	-2.8
Bone: stiffness	0.0	0.1	0.1	-0.3	-0.2	0.2	0.2	0.2
Tibialis anterior weight	1.0	3.4	4.7	1.9	1.8	-1.7	-2.2	-1.6
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1	-0.0
Time to tail flick, vehicle, after self-admin	3.5	4.6	6.0	-2.0	-2.3	2.3	1.6	2.5
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.3	0.4	-0.3	-0.3	-0.4
Time to tail flick, test, after self-admin	1.6	1.6	2.1	1.3	1.2	-1.5	-1.0	-1.4
Delta time to tail flick, vehicle, before/after SA	1.6	1.5	2.0	-1.2	-1.3	1.4	0.8	1.4
Delta time to tail flick, test, before/after SA	2.9	2.9	3.4	1.8	1.7	-1.8	-1.5	-1.8
Tibia length	0.9	2.5	4.6	-1.3	-1.5	1.3	2.1	1.5
Ambulatory time before self-admin	0.2	0.2	0.4	0.7	0.4	-0.2	-0.7	-0.3
Ambulatory time after self-admin	0.3	0.4	0.6	-0.6	-0.6	0.6	0.8	0.4
Bone: tissue strength	0.5	0.5	0.7	-0.7	-0.8	0.8	0.4	0.8
Total heroin consumption	2.0	2.4	2.8	1.4	1.6	-1.7	-1.4	-1.6
Bone: trabecular number	2.2	3.7	3.9	1.9	1.9	-1.9	-1.9	-2.0
Bone: trabecular spacing	0.7	0.9	1.4	-0.9	-0.9	0.9	1.2	1.0
Bone: trabecular thickness	0.3	0.3	0.5	0.6	0.6	-0.6	-0.3	-0.7
Bone: trabecular tissue density	0.3	0.4	0.6	0.8	0.6	-0.6	-0.8	-0.5
Water consumed over 24 hours	0.2	0.3	0.4	-0.7	-0.6	0.6	0.2	0.5
Number of responses in last shaping day	1.5	1.7	2.2	1.3	1.3	-1.5	-0.9	-1.3