Hub : Genes

Otof

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Otof 0.18 0.1 7.0e-10 0.2 0.22 0.23 0.23 6.9e-09 7.9e-10 6.1e-10 5.2e-10
2 Brain intron excision ratio chr6_31741943_31743487 0.03 0.03 9.8e-03 0.02 0.01 0.02 0.01 5.3e-03 3.8e-02 8.6e-03 1.4e-02
3 IL gene expression Otof 0.24 0.18 2.4e-04 0.1 0.12 0.1 0.13 1.7e-03 8.1e-04 1.9e-03 4.6e-04
4 NAcc gene expression Otof 0.06 0.05 8.9e-10 0.06 0.07 0.06 0.06 1.3e-09 3.0e-10 1.6e-09 9.1e-10
5 pVTA gene expression Otof 0.08 0.05 7.5e-10 0.1 0.12 0.1 0.1 1.5e-08 1.1e-09 1.3e-08 1.1e-08
6 PL intron excision ratio chr6_31741943_31743487 0.03 0.02 1.6e-03 0.01 0.02 0.01 0.01 1.8e-02 5.1e-03 2.8e-02 1.4e-02
7 OFC gene expression Otof 0.5 0.25 3.0e-08 0.29 0.3 0.31 0.3 1.2e-07 6.6e-08 5.1e-08 9.7e-08
8 Brain gene expression Otof 0.37 0.1 0.0e+00 0.52 0.54 0.53 0.53 7.6e-56 9.1e-60 6.3e-58 1.9e-58
9 NAcc intron excision ratio chr6_31741943_31743487 0.03 0.03 2.5e-03 0.01 0.01 0.01 0.01 7.2e-03 1.6e-02 1.3e-02 1.8e-02
10 PL gene expression Otof 0.13 0.07 0.0e+00 0.19 0.18 0.17 0.18 7.4e-20 3.8e-19 3.3e-18 8.1e-19
11 Brain mRNA stability Otof 0.05 0.05 7.8e-04 0.02 0.02 0.02 0.02 2.5e-03 8.0e-03 3.6e-03 4.1e-03
12 Adipose gene expression Otof 0.04 0.04 1.8e-03 0.02 0.01 0.01 0.01 4.3e-03 8.0e-03 8.0e-03 8.1e-03
13 RMTg gene expression Otof 0.13 0.1 6.8e-03 0.07 0.05 0.1 0.09 6.5e-03 2.0e-02 1.6e-03 2.0e-03
14 PL intron excision ratio chr6_31741325_31743487 0.03 0.02 6.3e-04 0.02 0.03 0.06 0.02 2.2e-03 1.6e-04 1.3e-06 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.24.17.12.0-2.22.02.32.12.2-2.31.9-1.9-1.92.72.4-1.4-0.6
Area under the delay curve0.00.00.10.10.00.10.00.00.0-0.20.00.0-0.20.10.10.20.3
BMI with tail1.34.47.1-2.02.5-2.5-1.9-2.4-2.11.7-2.72.62.6-1.2-0.90.02.3
BMI without tail0.84.16.3-1.92.2-2.4-2.1-2.3-2.21.9-2.52.52.5-1.6-1.40.71.3
Body weight2.310.013.7-3.43.7-3.2-3.4-3.3-3.33.5-3.13.32.9-3.3-3.22.22.0
Weight adjusted by age0.10.43.8-0.0-0.5-0.40.2-0.10.1-0.4-0.30.30.20.50.60.0-2.0
Bone surface0.61.13.80.8-1.20.81.10.91.0-1.20.7-0.6-0.72.01.5-0.3-0.8
Bone volume0.91.83.81.1-1.41.31.51.41.5-1.51.3-1.2-1.32.01.6-0.5-0.2
Breakpoint value in progressive ratio session0.61.02.30.8-0.51.01.00.91.0-1.00.8-0.8-1.01.31.2-1.11.5
Number of licking bursts0.31.01.9-0.81.1-1.3-0.8-1.1-0.90.7-1.31.31.3-0.2-0.2-0.11.4
Context. condit. distance diff. score0.10.20.40.5-0.30.60.30.50.4-0.20.6-0.6-0.6-0.10.0-0.30.2
Locomotion velocity, session 10.50.51.2-0.80.7-0.7-0.6-0.8-0.70.3-0.80.80.9-0.4-0.20.81.1
Locomotion distance, session 10.40.51.20.5-0.90.70.80.70.8-1.00.6-0.7-0.61.10.9-0.1-0.3
Locomotion velocity, session 20.10.20.6-0.40.4-0.2-0.4-0.3-0.40.6-0.10.10.2-0.8-0.70.10.2
Locomotion distance, session 20.10.10.8-0.5-0.2-0.3-0.2-0.3-0.30.2-0.30.30.3-0.1-0.10.4-0.9
Locomotion velocity, session 30.50.61.60.5-0.90.30.80.40.6-1.00.1-0.1-0.21.11.3-0.5-1.2
Locomotion distance, session 30.30.31.7-0.1-0.6-0.10.3-0.00.2-0.6-0.30.30.20.80.90.2-1.3
Stereotopy head waving bouts, day 32.22.73.31.8-1.61.61.81.71.8-1.61.5-1.6-1.61.71.8-1.7-0.4
Stereotopy head waving duration, day 30.50.71.00.9-0.50.80.80.90.9-0.70.8-0.9-0.90.70.8-1.00.7
Locomotion velocity, session 70.20.31.30.2-0.30.00.50.10.4-0.6-0.10.10.11.21.10.1-0.3
Locomotion distance, session 70.50.61.3-1.00.9-1.0-0.6-0.9-0.70.4-1.11.11.00.20.10.60.6
Stereotopy head waving bouts, day 70.10.11.1-0.1-0.3-0.10.0-0.0-0.00.1-0.10.00.10.00.1-0.2-1.0
Stereotopy head waving duration, day 70.60.82.60.8-1.30.70.80.80.8-0.80.7-0.7-0.70.60.7-0.7-1.6
Locomotion velocity, session 80.40.50.80.8-0.90.80.70.70.7-0.70.8-0.7-0.80.50.5-0.5-0.3
Locomotion distance, session 80.20.30.60.5-0.70.70.50.60.5-0.40.6-0.6-0.60.50.3-0.3-0.3
Degree of sensitization distance1.11.23.0-1.01.6-1.0-1.1-1.0-1.01.2-1.01.00.9-1.0-1.00.51.7
Degree of sensitization stereotypy0.30.41.7-0.60.1-0.6-0.5-0.5-0.60.7-0.60.50.6-0.6-0.50.1-1.3
Conditioned locomotion3.23.75.02.2-2.22.02.12.02.0-2.11.9-1.9-1.82.01.9-1.8-0.6
Cocaine response after cond. corrected0.20.31.40.2-0.00.40.40.40.5-0.50.4-0.3-0.40.90.6-0.41.2
Cocaine response after cond. not corrected0.60.81.30.9-0.71.01.00.91.0-1.10.9-0.9-0.91.11.0-0.90.6
Cocaine response before conditioning2.42.94.32.0-2.11.81.71.81.7-1.71.8-1.9-1.70.91.3-1.6-1.2
Saline control response1.01.42.11.3-1.41.21.21.21.2-0.91.2-1.2-1.21.00.9-1.2-1.2
Bone: connectivity density1.93.06.21.5-2.01.61.91.61.8-2.01.4-1.4-1.42.52.3-1.1-0.9
Bone: cortical apparent density0.10.20.70.4-0.10.30.40.30.3-0.40.2-0.2-0.20.70.5-0.60.8
Bone: cortical area0.10.10.5-0.2-0.1-0.10.1-0.10.1-0.2-0.20.20.20.70.50.4-0.4
Bone: cortical porosity2.42.73.81.6-1.91.71.71.81.7-1.61.8-1.7-1.91.11.3-1.4-1.2
Bone: cortical porosity2.12.33.11.4-1.71.71.61.71.6-1.61.7-1.6-1.81.11.3-1.1-0.7
Bone: cortical thickness0.20.30.5-0.60.3-0.6-0.6-0.6-0.60.6-0.60.70.6-0.3-0.50.7-0.6
Bone: cortical thickness0.40.51.50.7-0.80.50.80.60.8-0.90.5-0.4-0.51.21.1-0.40.0
Bone: cortical tissue density0.10.11.00.30.10.20.30.20.2-0.30.1-0.1-0.10.50.4-0.51.0
Condit. Reinf. active minus inactive responses1.61.83.1-1.41.8-1.4-1.3-1.4-1.31.2-1.51.51.5-1.0-0.91.21.1
Condit. Reinf. active-inactive response ratio1.31.42.3-1.31.5-1.2-1.1-1.3-1.21.0-1.31.31.3-0.9-0.71.31.0
Condit. Reinf. active responses0.10.10.8-0.20.4-0.3-0.1-0.3-0.2-0.1-0.40.40.40.00.10.00.9
Condit. Reinf. inactive responses0.91.22.31.1-1.21.11.11.11.1-1.21.0-1.0-1.01.11.1-1.50.1
Incentive salience index mean0.20.31.1-0.50.9-0.4-0.3-0.5-0.40.3-0.50.50.5-0.1-0.00.51.1
Condit. Reinf. lever presses0.50.71.10.8-0.41.10.90.90.9-0.81.0-1.0-1.00.80.7-0.60.7
Condit. Reinf. active minus inactive responses2.23.36.21.9-2.51.21.91.51.7-2.31.0-1.0-1.01.92.4-2.0-2.2
Condit. Reinf. active-inactive response ratio0.71.23.01.3-1.40.71.10.91.0-1.20.7-0.7-0.70.81.1-1.7-1.2
Condit. Reinf. active responses1.82.65.31.7-2.20.91.71.21.5-2.10.8-0.8-0.81.92.3-1.4-2.1
Condit. Reinf. inactive responses0.50.82.20.7-1.00.50.90.60.9-1.20.4-0.4-0.41.51.5-0.1-0.8
Condit. Reinf. lever presses1.52.24.01.9-2.01.21.51.41.4-1.61.2-1.2-1.11.31.5-1.2-1.9
Condit. Reinf. lever reinforcers received1.82.55.21.6-2.10.91.71.21.5-2.00.8-0.7-0.81.82.2-1.4-2.3
Conditioned reinforcement - actives1.45.78.72.9-2.53.02.52.62.5-2.42.8-2.8-2.31.91.9-1.5-0.6
Conditioned reinforcement - inactives2.15.88.02.8-1.42.62.42.52.5-2.22.6-2.5-2.62.02.1-2.52.7
Conditioned locomotion1.31.93.01.7-1.51.61.41.51.4-1.41.6-1.7-1.41.01.0-0.9-0.8
Patch foraging indifference point 0 sec0.30.91.6-1.21.1-1.2-0.9-1.0-0.91.0-1.11.00.9-0.6-0.50.50.1
Patch foraging indifference point AUC0.20.53.80.10.2-0.20.40.10.3-0.6-0.20.30.11.11.0-0.62.0
Delay disc. indifference point, 0s delay2.12.44.6-1.61.8-1.2-1.7-1.3-1.51.7-1.01.11.1-2.0-2.11.71.3
Delay disc. indifference point, 16s delay0.10.10.90.1-0.3-0.20.0-0.1-0.0-0.2-0.20.2-0.10.10.10.2-0.9
Delay disc. indifference point, 2s delay0.20.20.5-0.60.6-0.3-0.5-0.4-0.40.4-0.30.50.3-0.6-0.60.70.4
Delay disc. indifference point, 24s delay0.91.42.61.2-1.21.51.21.41.3-1.11.5-1.6-1.60.70.8-0.1-0.3
Delay disc. indifference point, 4s delay0.10.10.5-0.20.4-0.3-0.3-0.3-0.30.1-0.40.40.3-0.1-0.1-0.10.7
Delay disc. indifference point, 8s delay0.00.00.10.2-0.20.10.10.10.1-0.20.1-0.2-0.20.10.00.3-0.2
Indifference point function ln k0.41.32.81.2-1.31.40.91.21.0-0.61.5-1.5-1.50.30.2-0.3-1.7
Indifference point function log k0.41.32.81.2-1.31.40.91.21.0-0.61.5-1.5-1.50.30.2-0.3-1.7
Patch foraging total patch changes 0 sec0.30.91.8-1.31.2-1.3-1.0-1.0-1.01.0-1.21.20.9-0.6-0.60.30.3
Patch foraging total patch changes 12 sec1.41.93.7-1.51.9-1.5-1.3-1.3-1.31.4-1.41.51.1-1.2-1.00.51.9
Patch foraging total patch changes 18 sec0.51.12.2-1.21.2-1.4-0.9-1.1-1.00.9-1.41.51.2-0.2-0.30.20.8
Patch foraging total patch changes 24 sec0.51.62.3-1.31.3-1.5-1.3-1.4-1.41.2-1.51.51.3-1.2-1.10.40.2
Patch foraging total patch changes 6 sec1.11.93.8-1.71.5-1.9-1.1-1.5-1.30.8-1.91.91.7-0.5-0.10.81.0
Patch foraging time to switch 0 sec0.00.20.4-0.40.5-0.5-0.3-0.5-0.40.3-0.70.60.6-0.20.1-0.20.3
Patch foraging water rate 0 sec0.20.92.40.7-1.10.90.71.00.8-0.51.2-1.1-1.30.20.1-0.3-1.6
Patch foraging water rate 12 sec0.20.83.8-0.30.0-0.2-0.8-0.4-0.70.9-0.10.20.2-1.2-1.41.0-2.0
Patch foraging water rate 18 sec0.51.16.10.6-1.00.90.30.80.50.11.2-1.1-1.2-0.8-0.70.7-2.5
Patch foraging water rate 24 sec0.60.82.4-0.60.4-0.4-0.9-0.6-0.81.3-0.30.50.4-1.5-1.51.0-1.1
Patch foraging water rate 6 sec0.40.62.4-0.1-0.20.3-0.40.1-0.20.60.5-0.4-0.5-1.4-1.30.9-1.6
Seeking ratio, delayed vs. immediate footshock0.00.10.3-0.30.0-0.3-0.2-0.2-0.2-0.0-0.30.30.2-0.2-0.00.1-0.6
Distance traveled before self-admin0.10.32.50.4-0.60.50.00.20.1-0.00.5-0.5-0.2-0.2-0.40.7-1.6
Distance traveled after self-admin1.01.83.2-1.41.3-1.1-1.5-1.3-1.41.6-1.01.11.1-1.6-1.81.7-0.2
Extensor digitorum longus weight2.911.617.03.5-4.03.13.73.33.5-3.92.9-2.8-2.94.14.0-3.2-2.1
Bone: elastic displacement1.21.52.11.4-1.11.41.21.31.3-1.31.4-1.4-1.31.41.0-1.10.5
Bone: elastic work0.60.81.90.9-0.90.81.00.90.9-1.10.8-0.8-0.81.41.1-0.60.2
Bone: endosteal estimation0.20.41.50.3-0.50.50.70.50.7-0.70.4-0.5-0.41.21.10.00.4
Bone: endosteal perimeter0.00.10.5-0.0-0.10.00.20.10.2-0.5-0.0-0.1-0.10.70.60.20.3
Epididymis fat weight10.050.759.7-7.67.7-7.6-7.7-7.7-7.77.6-7.57.57.4-7.2-7.05.51.8
Delta time in closed arm before/after self-admin0.30.21.5-0.50.6-0.6-0.2-0.3-0.20.3-0.40.60.10.30.1-0.21.2
Delta time in open arm before/after self-admin0.10.10.20.3-0.10.10.30.10.2-0.3-0.0-0.10.00.40.5-0.50.4
Diff in mean of infusions in LGA sessions0.00.10.3-0.30.3-0.2-0.1-0.2-0.10.0-0.30.20.20.40.2-0.60.4
Delay discount exponential model param0.10.10.2-0.40.3-0.3-0.4-0.3-0.30.5-0.30.20.4-0.4-0.40.1-0.3
Extinction: sum of active levers before priming0.60.94.60.70.10.90.70.80.8-0.30.7-0.7-1.00.50.6-1.52.1
Active lever presses in extinction session 61.61.62.51.2-1.01.41.41.41.4-1.21.3-1.4-1.61.01.3-1.30.9
Bone: final force0.00.10.4-0.30.2-0.2-0.1-0.1-0.10.0-0.20.30.10.20.20.20.6
Bone: final moment0.00.10.4-0.30.2-0.2-0.0-0.1-0.0-0.1-0.20.30.10.30.20.30.7
Food consumed during 24 hour testing period0.00.10.10.1-0.1-0.4-0.0-0.2-0.1-0.2-0.40.30.30.40.3-0.2-0.2
Glucose0.60.91.4-1.11.0-1.2-1.0-1.1-1.00.8-1.21.11.2-0.4-0.60.70.3
Heart weight1.93.15.9-1.82.1-1.3-1.9-1.6-1.82.2-1.21.21.3-2.4-2.31.61.0
Delay discount hyperbolic model param0.00.10.5-0.1-0.1-0.1-0.2-0.1-0.10.3-0.0-0.00.2-0.3-0.30.0-0.7
Intermittent access intake day 1-15 change0.10.81.81.0-1.11.00.70.90.7-0.61.1-1.2-0.90.40.2-0.2-1.3
Intermittent access intake escalation0.10.31.30.6-0.70.60.30.50.4-0.30.7-0.8-0.60.0-0.10.1-1.2
Intermittent access intake escalation 20.10.21.60.2-0.50.30.00.1-0.00.00.2-0.2-0.1-0.0-0.20.4-1.3
Intermitt. access day 1 inactive lever presses0.11.63.11.4-1.01.11.41.31.3-1.51.1-1.1-1.21.21.4-1.80.0
Intermitt. access day 15 inactive lever presses0.63.46.91.9-1.41.32.01.61.9-2.31.2-1.2-1.52.52.6-2.51.0
Intermitt. access escalation Index1.13.56.7-2.22.0-2.5-1.8-2.2-1.91.7-2.62.42.4-0.8-0.70.50.7
Intermittent access day 1 total infusions1.64.96.72.6-2.52.32.42.22.3-2.52.1-2.1-1.92.32.4-1.9-0.7
Intermittent access day 15 total infusions1.33.24.42.1-2.12.01.91.91.9-1.82.0-2.1-1.81.51.5-1.2-1.0
Intermittent access terminal intake (last 3 days)2.54.36.12.4-2.52.32.22.22.2-2.12.2-2.3-2.11.81.8-1.5-1.2
Intermittent access total infusions4.14.96.82.6-2.52.52.32.42.3-2.22.4-2.5-2.31.91.9-1.6-0.8
Intermittent access day 1 locomotion1.62.94.61.9-1.41.91.81.81.8-1.81.8-1.7-1.71.51.6-2.20.2
Intermittent access day 15 total locomotion0.10.41.11.0-0.50.50.60.50.5-0.80.4-0.6-0.20.70.7-1.10.0
Intermittent access total locomotion1.31.53.01.6-0.81.41.21.21.2-1.11.3-1.5-1.20.90.9-1.70.6
Intermittent access standard deviation0.42.02.91.7-1.31.71.51.51.5-1.51.5-1.6-1.31.41.3-1.3-0.1
Left kidney weight0.00.30.90.2-0.10.50.30.60.50.10.8-0.8-1.0-0.2-0.1-0.20.8
Right kidney weight0.11.02.5-1.01.2-0.4-1.0-0.6-0.81.5-0.30.20.3-1.6-1.51.01.1
Cocaine induced anxiety0.10.32.60.20.20.20.30.30.3-0.30.1-0.2-0.30.50.5-0.91.6
Post-drug Anxiety1.51.82.9-1.41.7-1.4-1.4-1.4-1.41.3-1.31.31.2-1.3-1.30.91.1
Baseline Anxiety2.23.74.5-2.01.7-2.1-2.1-2.1-2.11.9-2.02.02.0-1.9-1.91.9-0.6
Tail length0.10.61.9-0.60.3-0.2-0.7-0.3-0.51.00.10.1-0.2-1.3-1.41.4-0.8
Length with tail0.62.87.8-1.71.6-0.9-1.8-1.1-1.52.3-0.50.70.4-2.6-2.82.30.2
Length without tail0.20.81.9-1.21.1-0.4-0.8-0.4-0.61.2-0.10.2-0.2-1.3-1.41.10.9
Times rat made contact with spout0.80.92.11.1-1.00.81.10.91.0-1.10.7-0.7-0.71.51.2-0.9-0.5
Lifetime Intake4.45.47.82.8-2.42.72.52.52.5-2.32.6-2.7-2.42.02.1-1.9-0.2
Liver weight, left2.64.47.3-2.32.3-1.8-2.3-2.0-2.12.4-1.71.81.7-2.7-2.52.31.1
Liver weight, right5.49.418.3-3.03.6-2.5-3.3-2.8-3.13.8-2.32.32.3-4.3-3.92.42.0
Locomotor activity0.81.25.4-0.91.7-1.0-0.9-0.9-0.81.0-1.01.00.9-0.6-0.6-0.32.3
Locomotor testing distance0.20.52.7-0.20.8-0.6-0.1-0.4-0.20.1-0.70.70.70.60.6-0.91.6
Locomotor testing rearing0.31.23.20.9-0.40.71.10.91.1-1.00.6-0.6-0.71.51.6-1.81.5
Locomotion in novel chamber0.00.00.1-0.1-0.1-0.2-0.1-0.2-0.10.1-0.30.30.3-0.20.0-0.0-0.3
Locomotion in novel chamber post-restriction1.33.84.7-2.12.2-2.1-2.1-2.0-2.02.1-2.02.12.0-1.9-1.81.21.3
Fecal boli incidents, locomotor time 10.61.63.01.3-1.51.51.11.51.3-0.81.6-1.7-1.70.50.6-0.7-1.0
Change in fecal boli incidents, locomotor task3.63.95.1-2.12.3-2.0-2.1-2.0-2.12.1-1.92.01.7-1.9-2.01.81.1
Time >=10cm from walls, locomotor time 10.20.20.50.5-0.30.50.10.50.3-0.10.7-0.7-0.7-0.4-0.40.10.3
Bouts of movement, locomotor time 10.60.75.20.3-1.0-0.00.60.20.4-0.8-0.10.20.11.11.2-0.2-2.3
Total resting periods, locomotor time 10.80.96.20.3-1.2-0.00.70.30.5-0.9-0.10.2-0.01.31.3-0.3-2.5
Rest time, locomotor task time 10.20.31.9-0.5-0.1-0.5-0.3-0.4-0.40.1-0.50.50.6-0.1-0.11.0-1.4
Distance moved, locomotor task time 10.30.84.9-0.41.1-0.3-0.7-0.5-0.61.0-0.20.20.1-1.1-1.1-0.12.2
Vertical activity count, locomotor time 10.10.31.7-0.30.6-0.3-0.5-0.4-0.40.7-0.20.40.1-0.8-0.80.21.3
Time >=10cm from walls, locomotor time 20.41.12.01.2-1.01.41.01.21.1-1.01.4-1.3-1.30.40.4-0.90.5
Bouts of movement, locomotor time 20.20.62.7-0.70.3-0.8-0.7-0.7-0.70.7-0.70.80.5-0.5-0.70.9-1.6
Total resting periods, locomotor time 20.20.64.4-0.60.0-0.8-0.5-0.6-0.60.4-0.80.80.5-0.1-0.30.8-2.1
Rest time, locomotor task time 20.30.52.40.3-0.90.00.60.20.4-0.8-0.1-0.10.11.21.1-0.2-1.6
Distance moved, locomotor task time 20.50.64.9-0.10.90.0-0.5-0.2-0.30.60.10.1-0.0-1.1-0.9-0.32.2
Vertical activity count, locomotor time 20.10.31.90.10.40.3-0.20.2-0.00.30.4-0.2-0.4-0.8-0.70.21.4
Light reinforcement 10.52.25.71.0-1.51.01.61.21.5-1.60.8-0.9-1.12.42.2-1.4-1.8
Light reinforcement 20.92.03.81.2-1.81.21.41.31.4-1.41.1-1.1-1.21.91.6-0.7-1.9
Bone: marrow area0.20.41.50.3-0.50.50.70.50.7-0.80.4-0.5-0.41.21.1-0.00.4
Bone: maximum diameter0.20.31.90.0-0.30.10.50.20.4-0.6-0.1-0.0-0.01.41.20.2-0.1
Bone: maximum force0.00.00.20.0-0.10.00.20.10.2-0.30.1-0.0-0.10.40.3-0.10.4
Bone: maximum moment0.00.10.30.1-0.20.10.30.20.3-0.40.1-0.1-0.20.50.5-0.00.4
Mean time between licks in bursts0.42.74.0-1.61.8-1.5-1.8-1.6-1.71.9-1.41.31.4-2.0-1.91.60.9
Mean num. licks in bursts0.51.32.51.1-1.31.41.01.31.1-0.81.4-1.4-1.40.70.5-0.1-1.6
Cd content in liver0.00.00.1-0.20.3-0.0-0.1-0.1-0.10.3-0.10.00.10.2-0.0-0.10.2
Co content in liver4.85.67.12.5-2.42.42.52.62.6-2.52.5-2.7-2.62.52.2-1.8-0.5
Cu content in liver0.30.40.50.7-0.40.70.60.70.6-0.70.7-0.7-0.70.20.4-0.70.6
Fe content in liver2.02.55.01.4-0.91.61.61.61.7-1.61.5-1.6-1.51.21.6-1.62.2
K content in liver0.20.21.4-0.70.6-0.4-0.2-0.3-0.10.0-0.40.10.30.30.30.61.2
Mg content in liver0.30.43.4-0.70.7-0.2-0.0-0.00.10.1-0.1-0.3-0.10.40.30.21.9
Mn content in liver0.50.61.3-1.10.9-1.0-0.4-0.8-0.50.3-1.10.70.80.50.40.40.9
Na content in liver1.31.52.51.3-1.11.41.21.41.3-1.31.6-1.6-1.60.60.8-0.60.5
Rb content in liver0.30.43.7-0.70.9-0.4-0.2-0.3-0.20.2-0.40.30.20.00.20.21.9
Se content in liver0.30.43.1-0.50.8-0.4-0.3-0.4-0.30.2-0.40.20.4-0.20.0-0.61.8
Sr content in liver0.10.10.50.3-0.30.2-0.10.1-0.00.00.3-0.3-0.3-0.5-0.60.4-0.7
Zn content in liver0.81.01.7-1.21.3-1.0-1.0-0.9-0.91.0-0.80.50.6-1.0-1.11.11.0
Bone: minimum diameter0.40.71.4-1.20.9-1.0-0.8-0.9-0.80.8-1.00.90.9-0.3-0.41.10.3
Time in familiar zone, hab. session 10.80.81.4-1.21.2-0.8-0.9-0.9-0.91.0-0.90.90.8-0.7-0.80.91.0
Time in novel zone, hab. session 10.20.20.3-0.30.4-0.5-0.4-0.4-0.40.4-0.50.40.5-0.5-0.30.2-0.5
Total zone transitions, hab. session 10.10.21.00.3-0.50.50.30.40.4-0.20.5-0.4-0.40.30.1-0.3-1.0
Total locomotion distance, hab. session 10.30.51.00.7-0.51.00.60.80.7-0.41.0-1.0-1.00.40.2-0.40.4
Locomotion velocity, hab. session 10.91.31.91.2-1.01.41.11.31.2-1.01.4-1.3-1.41.00.8-0.90.3
Time in familiar zone, hab. session 20.10.20.4-0.40.4-0.6-0.3-0.5-0.40.3-0.60.50.50.2-0.1-0.1-0.2
Time in novel zone, hab. session 20.20.20.6-0.40.5-0.1-0.3-0.2-0.30.4-0.10.10.1-0.8-0.50.80.6
Total zone transitions, hab. session 20.20.31.5-0.6-0.1-0.4-0.3-0.4-0.30.2-0.50.50.50.10.00.7-1.2
Total locomotion distance, hab. session 20.20.21.0-0.5-0.1-0.5-0.2-0.4-0.30.0-0.60.50.50.20.10.4-1.0
Locomotion velocity, hab. session 20.10.21.1-0.3-0.3-0.3-0.0-0.2-0.1-0.2-0.40.40.40.40.30.2-1.1
Novel to familiar place preference ratio0.70.91.6-1.10.9-0.8-1.0-0.8-0.91.2-0.70.70.7-1.3-1.21.1-0.5
Novelty place preference1.11.42.2-1.31.1-1.0-1.2-1.1-1.21.5-0.90.90.9-1.5-1.41.3-0.5
Time in novel zone, NPP test1.11.32.5-1.31.1-0.9-1.2-1.1-1.21.5-0.90.90.9-1.6-1.41.3-0.4
Total zone transitions, NPP test1.01.42.31.1-1.51.21.31.21.2-1.31.1-1.2-1.11.11.2-1.1-0.8
Total locomotion distance, NPP test1.31.82.51.3-1.61.31.51.41.4-1.51.2-1.3-1.31.41.5-1.2-0.9
Locomotion velocity, NPP test1.82.63.81.5-1.91.61.81.61.7-1.91.5-1.5-1.51.91.8-1.4-0.9
Intraocular pressure4.67.511.2-2.93.4-2.6-2.9-2.8-2.83.1-2.62.52.5-2.8-2.82.32.0
Delta distance traveled before/after self-admin2.12.33.6-1.61.8-1.8-1.6-1.6-1.61.5-1.71.91.5-1.4-1.20.90.8
Delta ambulatory time before/after self-admin0.40.71.3-1.01.1-1.0-0.8-0.8-0.80.8-1.01.10.7-0.5-0.40.31.1
Parametrial fat weight15.636.745.3-6.55.6-6.7-6.6-6.7-6.76.1-6.66.56.7-5.7-5.95.3-1.4
Pavlov. Cond. lever latency0.60.81.7-0.80.7-0.8-1.0-0.8-0.91.1-0.70.80.7-1.3-1.20.7-0.6
Pavlov. Cond. magazine entry latency0.10.10.8-0.20.4-0.10.0-0.1-0.0-0.1-0.20.10.10.10.30.00.9
Pavlov. Cond. change in total contacts0.10.10.90.00.20.30.20.20.2-0.20.2-0.3-0.20.10.10.11.0
Pavlov. Cond. index score0.20.21.20.10.10.30.40.30.4-0.50.2-0.2-0.20.70.7-0.21.1
Pavlov. Cond. latency score0.10.20.90.00.10.20.40.20.3-0.50.0-0.1-0.10.70.7-0.21.0
Pavlov. Cond. lever contacts0.50.51.00.6-0.50.80.80.70.8-0.90.7-0.8-0.71.00.9-0.40.6
Pavlov. Cond. magazine entry number0.10.10.5-0.1-0.1-0.2-0.3-0.2-0.30.5-0.00.10.1-0.5-0.60.1-0.7
Pavlov. Cond. intertrial magazine entries1.92.33.81.9-1.41.61.51.61.6-1.51.6-1.6-1.71.11.3-1.90.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.30.5-0.40.70.80.70.8-0.90.6-0.6-0.61.11.1-0.51.0
Pavlov. Cond. response bias0.70.91.40.8-0.61.01.00.91.0-1.10.9-0.9-0.91.11.2-0.60.9
Pavlov. Cond. lever latency1.01.53.4-1.51.7-0.9-1.2-1.0-1.11.4-0.90.80.8-1.1-1.21.01.8
Pavlov. Cond. magazine entry latency0.20.32.20.4-0.6-0.30.1-0.00.0-0.5-0.20.30.20.40.4-0.0-1.5
Pavlov. Cond. change in total contacts0.20.52.10.9-1.10.20.60.40.4-0.80.10.0-0.10.90.8-0.7-1.4
Pavlov. Cond. index score0.71.03.71.2-1.50.50.90.70.8-1.20.5-0.4-0.51.01.1-0.7-1.9
Pavlov. Cond. latency score0.71.14.11.3-1.50.50.90.80.8-1.20.6-0.5-0.51.01.0-0.8-2.0
Pavlov. Cond. lever contacts0.71.02.51.2-1.40.61.00.80.9-1.10.7-0.6-0.60.91.0-0.8-1.6
Pavlov. Cond. magazine entry number0.10.20.9-0.20.30.40.00.20.10.30.4-0.5-0.4-0.3-0.20.11.0
Pavlov. Cond. intertrial magazine entries1.84.05.5-2.32.2-1.9-2.1-2.0-2.12.2-1.81.81.7-2.3-2.11.90.5
Pavlov. Cond. lever-magazine prob. diff.0.40.62.60.9-1.10.10.60.40.5-0.90.2-0.1-0.20.80.8-0.5-1.6
Pavlov. Cond. response bias1.01.42.71.5-1.60.81.21.01.1-1.50.8-0.7-0.71.21.3-1.0-1.5
Time in closed arm before self-admin0.30.40.8-0.60.8-0.5-0.8-0.7-0.80.9-0.60.40.8-0.8-0.9-0.30.2
Time in closed arm after self-admin0.70.81.3-0.81.1-0.9-1.0-1.1-1.01.0-1.01.01.2-0.8-0.80.10.6
Time in open arm before self-admin0.00.00.4-0.1-0.2-0.2-0.00.10.0-0.0-0.00.3-0.30.10.10.1-0.6
Time in open arm after self-admin0.50.61.10.8-0.60.60.90.70.8-0.80.5-0.6-0.51.01.1-0.80.4
Bone: periosteal estimation0.20.51.80.3-0.60.50.70.50.7-0.80.4-0.5-0.51.31.10.00.0
Bone: periosteal perimeter0.00.10.40.0-0.20.00.30.20.3-0.40.0-0.1-0.10.70.60.1-0.0
Bone: post-yield work1.32.22.81.6-1.51.61.51.71.6-1.51.6-1.6-1.71.21.2-1.5-0.3
Progressive ratio test 1 active lever presses1.83.24.72.1-1.72.21.92.01.9-1.82.0-2.1-1.91.51.6-1.3-0.0
Progressive ratio test 1 breakpoint1.93.34.82.1-1.72.21.92.02.0-1.82.1-2.1-1.91.51.6-1.3-0.1
Progressive ratio test 1 inactive lever presses2.46.28.83.0-2.12.72.72.72.7-2.62.6-2.7-2.62.22.4-2.40.9
Progressive ratio test 2 active lever presses1.72.44.21.9-1.62.01.51.81.6-1.22.1-2.0-2.00.70.8-0.5-0.4
Progressive ratio test 2 breakpoint1.72.24.01.8-1.51.91.41.71.5-1.12.0-1.9-1.90.60.7-0.4-0.5
Progressive ratio test 2 inactive lever presses1.23.75.52.3-1.82.22.02.12.1-1.92.2-2.2-2.11.61.6-1.50.3
Incentive Sensitization - Responses0.51.33.11.3-1.11.41.01.41.2-0.71.6-1.5-1.80.40.4-0.40.1
Incentive Sensitization - Breakpoint0.40.92.41.1-0.91.20.81.21.0-0.51.4-1.3-1.50.20.2-0.2-0.0
Sum of active levers in priming session hrs 5-60.40.42.7-0.40.7-0.5-0.1-0.3-0.10.0-0.60.60.20.30.5-0.81.6
Progressive ratio0.00.10.5-0.20.4-0.3-0.1-0.2-0.10.0-0.30.20.2-0.00.1-0.20.7
Food seeking constrained by brief footshock8.410.518.03.3-2.83.73.43.83.6-2.94.0-3.8-4.22.32.5-2.60.8
Seeking ratio, punishment vs. effort0.61.42.51.2-1.11.51.21.41.3-0.91.6-1.5-1.60.70.6-0.4-0.1
Retroperitoneal fat weight25.4113.9145.3-11.610.9-12.0-11.4-11.9-11.610.7-12.111.811.9-9.5-9.48.31.0
Reaction time number correct0.10.52.50.5-1.10.40.60.50.6-0.70.5-0.4-0.40.80.7-0.1-1.6
Reaction time mean minus median0.00.10.40.6-0.40.30.10.10.1-0.40.0-0.00.10.20.2-0.4-0.2
Reaction time mean minus median AUC0.00.00.10.10.2-0.1-0.2-0.3-0.30.1-0.30.30.3-0.1-0.2-0.20.1
Reaction time num false alarms0.91.52.9-1.61.4-1.6-1.1-1.4-1.21.0-1.71.71.5-0.2-0.20.8-0.1
Reaction time num false alarms AUC0.71.63.2-1.61.4-1.7-1.1-1.5-1.21.1-1.81.71.6-0.2-0.30.7-0.0
Reaction time trials correct on left0.10.52.50.5-1.10.40.60.50.6-0.70.5-0.4-0.40.80.7-0.1-1.6
Reaction time trials on left0.10.52.30.5-1.10.40.70.50.6-0.70.5-0.3-0.40.80.7-0.1-1.5
Reaction time mean0.30.62.0-0.40.8-0.1-0.8-0.5-0.71.0-0.10.10.2-1.4-1.40.81.2
Reaction time mean AUC0.20.51.8-0.30.70.0-0.7-0.4-0.60.9-0.00.00.1-1.3-1.20.71.1
Median of all reaction times0.60.92.6-0.51.0-0.1-0.9-0.5-0.71.1-0.00.10.1-1.6-1.60.81.5
Reaction time omissions0.10.21.6-0.20.5-0.1-0.1-0.3-0.10.1-0.40.40.40.10.3-0.31.3
Reaction time false alarm rate1.52.13.6-1.81.8-1.8-1.4-1.7-1.51.3-1.91.81.7-0.5-0.60.90.5
Reaction time premature initiation rate0.10.20.7-0.30.1-0.4-0.4-0.4-0.40.2-0.40.40.4-0.5-0.30.1-0.8
Reaction time premature initiations0.10.21.9-0.0-0.4-0.2-0.0-0.1-0.1-0.1-0.10.20.1-0.10.1-0.0-1.4
Std. dev. reaction times0.10.20.5-0.10.3-0.2-0.5-0.5-0.50.4-0.40.40.6-0.6-0.60.70.2
Reaction time trials completed0.10.52.30.5-1.10.40.70.50.6-0.70.5-0.3-0.40.80.7-0.1-1.5
Reaction time trials AUC0.20.62.60.6-1.20.40.80.60.7-0.80.5-0.4-0.40.90.9-0.3-1.6
Run reversals in cocaine runway, females0.40.41.70.6-0.80.70.30.60.4-0.20.8-0.8-0.6-0.2-0.20.5-1.3
Run reversals in cocaine runway, males0.50.61.00.8-0.90.90.70.80.7-0.61.0-0.9-0.90.30.10.1-0.8
Latency to leave start box in cocaine runway0.50.71.11.0-0.90.90.90.90.9-1.10.9-0.9-0.80.90.8-0.60.3
Latency to leave start box in cocaine runway, F0.20.20.60.5-0.20.30.40.30.4-0.50.3-0.3-0.30.50.4-0.80.8
Latency to leave start box in cocaine runway, M0.70.61.40.7-1.20.80.70.80.7-0.80.9-0.9-0.80.40.40.6-1.2
Std. dev. time between licks in bursts0.61.11.9-1.01.4-1.2-1.0-1.1-1.01.1-1.21.11.1-0.6-0.60.21.4
Total sessions with >9 infusions2.22.74.32.0-1.52.11.71.81.7-1.51.9-2.0-1.61.31.4-1.1-0.3
Short access day 1 total inactive lever presses3.97.710.43.2-1.93.03.02.82.9-2.82.7-2.7-2.42.93.1-2.92.1
Short access day 10 total inactive lever presses0.32.13.91.5-1.21.21.71.31.5-1.91.0-1.0-1.01.92.0-1.90.3
Short access day 1 total infusions3.06.08.52.9-2.12.62.72.52.6-2.62.5-2.5-2.12.62.7-2.20.7
Short access day 10 total infusions2.84.76.82.6-2.12.62.32.42.3-2.12.5-2.5-2.31.71.9-1.7-0.0
Short access total infusions2.33.24.92.2-1.62.21.91.91.9-1.62.0-2.0-1.81.51.6-1.70.4
Short access day 1 locomotion2.54.26.22.5-2.22.02.22.02.1-2.41.9-1.9-1.62.22.3-1.7-1.1
Short access day 10 total locomotion0.62.32.91.5-1.71.51.61.61.6-1.61.5-1.6-1.41.31.5-1.5-1.6
Short access total locomotion0.71.11.61.2-0.91.31.11.21.1-1.01.3-1.3-1.10.60.8-1.0-0.3
One hour access (0.3 mA shock)2.52.95.02.1-2.12.21.71.81.7-1.62.1-2.1-1.71.21.1-0.6-1.2
Compulsive drug intake1.62.43.3-1.71.8-1.5-1.6-1.7-1.71.7-1.71.61.8-1.3-1.31.00.6
One hour access (shock baseline)2.15.47.92.7-2.82.72.32.62.4-2.32.7-2.7-2.71.71.7-1.0-1.2
Social response proportion0.10.21.2-0.10.10.2-0.20.0-0.10.20.3-0.4-0.2-0.4-0.51.1-0.2
Social responses0.20.30.8-0.70.4-0.6-0.5-0.5-0.50.5-0.50.30.4-0.4-0.40.9-0.6
Social time0.10.10.6-0.10.10.1-0.20.1-0.10.40.3-0.3-0.2-0.6-0.60.3-0.8
Soleus weight3.39.613.33.3-3.63.13.33.23.2-3.42.9-2.9-2.93.53.2-2.8-1.7
Bone: stiffness0.00.00.2-0.20.1-0.3-0.2-0.2-0.20.1-0.30.40.2-0.2-0.1-0.1-0.3
Tibialis anterior weight1.86.211.22.3-3.12.02.72.22.5-3.01.7-1.7-1.73.33.2-2.3-2.1
Time to tail flick, vehicle, before self-admin0.10.20.4-0.30.2-0.3-0.4-0.2-0.30.6-0.10.1-0.1-0.7-0.70.6-0.3
Time to tail flick, vehicle, after self-admin2.04.06.3-1.91.7-2.1-2.2-2.3-2.31.9-2.21.92.5-1.7-2.02.0-0.5
Time to tail flick, test, before self-admin0.20.20.50.6-0.20.30.40.40.4-0.30.3-0.4-0.30.30.4-0.60.7
Time to tail flick, test, after self-admin0.90.91.80.9-1.21.00.71.00.8-0.51.2-1.4-1.20.30.2-0.3-1.3
Delta time to tail flick, vehicle, before/after SA0.70.82.4-0.80.6-1.1-0.8-1.2-1.00.5-1.31.21.5-0.1-0.30.4-0.4
Delta time to tail flick, test, before/after SA1.62.03.01.4-1.71.61.41.61.4-1.21.6-1.7-1.61.10.9-0.9-1.1
Tibia length1.64.57.7-2.32.5-1.5-2.3-1.8-2.02.7-1.41.41.3-2.8-2.72.61.2
Ambulatory time before self-admin0.10.32.00.5-0.70.60.20.30.2-0.10.6-0.7-0.3-0.1-0.30.2-1.4
Ambulatory time after self-admin0.60.92.0-1.01.1-0.6-1.1-0.8-1.01.2-0.60.60.6-1.4-1.41.00.3
Bone: tissue strength0.70.71.6-0.80.4-0.8-0.9-0.8-0.90.8-0.70.90.8-1.0-0.91.3-0.8
Total heroin consumption2.12.53.11.8-1.41.71.71.71.7-1.61.5-1.5-1.71.71.6-1.70.4
Bone: trabecular number1.83.44.91.7-1.82.02.02.02.1-2.01.9-1.9-1.92.22.1-0.80.1
Bone: trabecular spacing1.11.64.8-1.11.4-1.0-1.4-1.1-1.31.6-0.90.90.9-2.2-1.80.30.5
Bone: trabecular thickness0.30.41.10.4-0.40.60.70.60.7-0.70.6-0.7-0.61.10.8-0.00.6
Bone: trabecular tissue density0.30.51.01.0-0.60.70.70.70.7-0.70.7-0.6-0.50.50.6-1.00.4
Water consumed over 24 hours0.10.20.4-0.10.1-0.6-0.1-0.4-0.2-0.1-0.60.70.60.50.4-0.20.2
Number of responses in last shaping day0.81.12.11.4-0.81.21.01.21.1-0.71.4-1.1-1.40.70.7-0.40.8