Hub : Genes

Otof

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Otof 0.18 0.1 7.0e-10 0.2 0.22 0.23 0.23 6.9e-09 7.9e-10 6.1e-10 5.3e-10
2 Brain intron excision ratio chr6_31741943_31743487 0.03 0.03 9.8e-03 0.02 0.01 0.02 0.01 5.3e-03 3.8e-02 8.6e-03 1.4e-02
3 IL gene expression Otof 0.24 0.18 2.4e-04 0.1 0.12 0.08 0.13 1.7e-03 8.1e-04 5.6e-03 4.9e-04
4 NAcc gene expression Otof 0.06 0.05 8.9e-10 0.06 0.07 0.06 0.06 1.3e-09 3.0e-10 1.6e-09 9.0e-10
5 pVTA gene expression Otof 0.08 0.05 7.5e-10 0.1 0.12 0.1 0.1 1.5e-08 1.1e-09 1.4e-08 1.2e-08
6 PL intron excision ratio chr6_31741943_31743487 0.03 0.02 1.6e-03 0.01 0.02 0.01 0.01 1.8e-02 5.1e-03 2.8e-02 1.4e-02
7 OFC gene expression Otof 0.5 0.25 3.0e-08 0.29 0.3 0.31 0.3 1.2e-07 6.6e-08 5.1e-08 9.6e-08
8 Brain gene expression Otof 0.37 0.1 0.0e+00 0.52 0.54 0.53 0.54 7.6e-56 9.1e-60 6.6e-58 1.8e-58
9 NAcc intron excision ratio chr6_31741943_31743487 0.03 0.03 2.5e-03 0.01 0.01 0.01 0.01 7.2e-03 1.6e-02 1.3e-02 1.8e-02
10 PL gene expression Otof 0.13 0.07 0.0e+00 0.19 0.18 0.17 0.18 7.4e-20 3.8e-19 3.1e-18 8.2e-19
11 Brain mRNA stability Otof 0.05 0.05 7.8e-04 0.02 0.02 0.02 0.02 2.5e-03 8.0e-03 3.6e-03 4.9e-03
12 Adipose gene expression Otof 0.04 0.04 1.8e-03 0.02 0.01 0.01 0.01 4.3e-03 8.0e-03 8.0e-03 7.9e-03
13 RMTg gene expression Otof 0.13 0.1 6.8e-03 0.07 0.05 0.1 0.09 6.5e-03 2.0e-02 1.7e-03 1.9e-03
14 PL intron excision ratio chr6_31741325_31743487 0.03 0.02 6.3e-04 0.02 0.03 0.06 0.02 2.2e-03 1.6e-04 1.3e-06 1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.44.27.12.02.22.12.32.12.22.31.91.91.9-2.7-2.41.50.7
Area under the delay curve0.00.00.10.1-0.00.10.00.00.00.20.0-0.00.2-0.1-0.1-0.2-0.3
BMI with tail1.34.47.1-2.0-2.5-2.5-1.9-2.4-2.1-1.7-2.7-2.6-2.61.20.9-0.3-2.3
BMI without tail1.44.26.3-1.9-2.2-2.4-2.1-2.3-2.2-1.9-2.5-2.5-2.51.61.4-0.9-1.4
Body weight2.310.113.7-3.4-3.7-3.2-3.4-3.3-3.3-3.5-3.1-3.3-2.93.33.2-2.4-2.1
Weight adjusted by age0.30.43.9-0.00.5-0.40.2-0.10.10.4-0.3-0.3-0.2-0.5-0.6-0.12.0
Bone surface0.61.13.80.81.20.81.10.91.01.20.70.60.7-2.0-1.50.40.8
Bone volume1.01.83.81.11.41.41.51.41.51.51.31.21.3-2.0-1.60.60.2
Breakpoint value in progressive ratio session0.91.02.30.80.51.01.00.91.01.00.80.81.0-1.3-1.21.1-1.5
Number of licking bursts0.61.02.0-0.8-1.1-1.3-0.8-1.1-0.9-0.7-1.3-1.3-1.30.20.2-0.1-1.4
Context. condit. distance diff. score0.10.20.40.50.30.60.30.50.40.20.60.60.60.1-0.00.4-0.1
Locomotion velocity, session 10.50.51.3-0.8-0.7-0.7-0.6-0.8-0.7-0.3-0.8-0.8-0.90.40.2-0.8-1.2
Locomotion distance, session 10.40.51.20.50.90.70.80.70.81.00.60.70.6-1.1-0.90.10.3
Locomotion velocity, session 20.10.20.6-0.4-0.4-0.2-0.4-0.3-0.4-0.6-0.1-0.1-0.20.80.7-0.1-0.2
Locomotion distance, session 20.10.10.7-0.50.2-0.3-0.2-0.3-0.3-0.2-0.3-0.3-0.30.10.1-0.40.9
Locomotion velocity, session 30.50.61.60.50.90.30.80.40.61.00.10.10.2-1.1-1.30.51.2
Locomotion distance, session 30.30.31.7-0.10.6-0.10.3-0.00.20.6-0.3-0.3-0.2-0.8-0.9-0.21.3
Stereotopy head waving bouts, day 32.32.73.31.81.61.61.81.71.81.61.51.61.6-1.7-1.81.70.4
Stereotopy head waving duration, day 30.50.71.10.90.50.80.80.90.90.70.80.90.9-0.7-0.81.1-0.6
Locomotion velocity, session 70.20.31.30.20.30.00.50.10.40.6-0.1-0.1-0.1-1.2-1.1-0.10.4
Locomotion distance, session 70.50.61.3-1.0-0.9-1.0-0.6-0.9-0.7-0.4-1.1-1.1-1.0-0.2-0.1-0.6-0.7
Stereotopy head waving bouts, day 70.10.11.1-0.10.3-0.10.0-0.0-0.0-0.1-0.1-0.0-0.1-0.0-0.10.21.1
Stereotopy head waving duration, day 70.70.82.80.81.30.70.80.80.80.80.70.70.7-0.6-0.70.71.7
Locomotion velocity, session 80.40.50.80.80.90.80.70.70.70.70.80.70.8-0.5-0.50.50.4
Locomotion distance, session 80.20.30.60.50.70.70.50.60.50.40.60.60.6-0.5-0.30.40.3
Degree of sensitization distance1.21.23.2-1.0-1.6-1.0-1.1-1.0-1.0-1.2-1.0-1.0-0.91.01.0-0.6-1.8
Degree of sensitization stereotypy0.30.41.7-0.6-0.1-0.6-0.5-0.5-0.6-0.7-0.6-0.5-0.60.60.5-0.21.3
Conditioned locomotion3.33.75.02.22.22.02.12.02.02.11.91.91.8-2.0-1.91.80.6
Cocaine response after cond. corrected0.30.31.50.20.00.40.40.40.50.50.40.30.4-0.9-0.60.4-1.2
Cocaine response after cond. not corrected0.70.81.30.90.71.01.00.91.01.10.90.90.9-1.1-1.00.9-0.6
Cocaine response before conditioning2.42.94.32.02.11.81.71.81.71.71.81.91.7-0.9-1.31.71.3
Saline control response1.01.42.11.31.41.21.21.21.20.91.21.21.2-1.0-0.91.21.2
Bone: connectivity density1.93.06.21.52.01.61.91.61.82.01.41.41.4-2.5-2.31.20.9
Bone: cortical apparent density0.10.20.70.40.10.30.40.30.30.40.20.20.2-0.7-0.50.6-0.8
Bone: cortical area0.10.10.5-0.20.1-0.10.1-0.10.10.2-0.2-0.2-0.2-0.7-0.5-0.30.4
Bone: cortical porosity2.52.73.81.61.91.71.71.81.71.61.81.71.9-1.1-1.31.51.3
Bone: cortical porosity2.12.33.11.41.71.71.61.71.61.61.71.61.8-1.1-1.31.20.7
Bone: cortical thickness0.20.30.5-0.6-0.3-0.6-0.6-0.6-0.6-0.6-0.6-0.7-0.60.30.5-0.70.6
Bone: cortical thickness0.50.51.50.70.80.50.80.60.80.90.50.40.5-1.2-1.10.5-0.0
Bone: cortical tissue density0.10.11.00.3-0.10.20.30.20.20.30.10.10.1-0.5-0.40.5-1.0
Condit. Reinf. active minus inactive responses1.61.83.1-1.4-1.8-1.4-1.3-1.4-1.3-1.2-1.5-1.5-1.51.00.9-1.3-1.1
Condit. Reinf. active-inactive response ratio1.41.52.3-1.3-1.5-1.2-1.1-1.3-1.2-1.0-1.3-1.3-1.30.90.7-1.4-1.1
Condit. Reinf. active responses0.10.10.8-0.2-0.4-0.3-0.1-0.3-0.20.1-0.4-0.4-0.4-0.0-0.1-0.0-0.9
Condit. Reinf. inactive responses1.01.22.31.11.21.11.11.11.11.21.01.01.0-1.1-1.11.5-0.0
Incentive salience index mean0.20.31.2-0.5-0.9-0.4-0.3-0.5-0.4-0.3-0.5-0.5-0.50.10.0-0.5-1.1
Condit. Reinf. lever presses0.50.71.10.80.41.10.90.90.90.81.01.01.0-0.8-0.70.7-0.7
Condit. Reinf. active minus inactive responses2.63.46.21.92.51.21.91.51.72.31.01.01.0-1.9-2.42.02.3
Condit. Reinf. active-inactive response ratio1.01.22.81.31.40.71.10.91.01.20.70.70.7-0.8-1.11.71.3
Condit. Reinf. active responses1.92.75.31.72.20.91.71.21.52.10.80.80.8-1.9-2.31.42.2
Condit. Reinf. inactive responses0.60.82.20.71.00.50.90.60.91.20.40.40.4-1.5-1.50.10.8
Condit. Reinf. lever presses1.62.34.21.92.01.21.51.41.41.61.21.21.1-1.3-1.51.32.0
Condit. Reinf. lever reinforcers received1.82.65.71.62.10.91.71.21.52.00.80.70.8-1.8-2.21.42.4
Conditioned reinforcement - actives3.35.78.72.92.53.02.52.62.52.42.82.82.3-1.9-1.91.70.7
Conditioned reinforcement - inactives4.05.88.02.81.42.62.42.52.52.22.62.52.6-2.0-2.12.6-2.6
Conditioned locomotion1.51.93.01.71.51.61.41.51.41.41.61.71.4-1.0-1.01.10.8
Patch foraging indifference point 0 sec0.50.91.6-1.2-1.1-1.2-0.9-1.0-0.9-1.0-1.1-1.0-0.90.60.5-0.6-0.2
Patch foraging indifference point AUC0.40.53.90.1-0.2-0.20.40.10.30.6-0.2-0.3-0.1-1.1-1.00.6-2.0
Delay disc. indifference point, 0s delay2.22.44.6-1.6-1.8-1.2-1.7-1.3-1.5-1.7-1.0-1.1-1.12.02.1-1.7-1.4
Delay disc. indifference point, 16s delay0.10.11.00.10.3-0.20.0-0.1-0.00.2-0.2-0.20.1-0.1-0.1-0.21.0
Delay disc. indifference point, 2s delay0.20.20.5-0.6-0.6-0.3-0.5-0.4-0.4-0.4-0.3-0.5-0.30.60.6-0.7-0.4
Delay disc. indifference point, 24s delay1.31.42.61.21.21.51.21.41.31.11.51.61.6-0.7-0.80.20.3
Delay disc. indifference point, 4s delay0.10.10.6-0.2-0.4-0.3-0.3-0.3-0.3-0.1-0.4-0.4-0.30.10.1-0.0-0.7
Delay disc. indifference point, 8s delay0.00.00.10.20.20.10.10.10.10.20.10.20.2-0.1-0.0-0.20.2
Indifference point function ln k0.81.33.01.21.31.40.91.21.00.61.51.51.5-0.3-0.20.41.7
Indifference point function log k0.81.33.01.21.31.40.91.21.00.61.51.51.5-0.3-0.20.41.7
Patch foraging total patch changes 0 sec0.51.01.8-1.3-1.2-1.3-1.0-1.0-1.0-1.0-1.2-1.2-0.90.60.6-0.3-0.3
Patch foraging total patch changes 12 sec1.51.93.8-1.5-1.9-1.5-1.3-1.3-1.3-1.4-1.4-1.5-1.11.21.0-0.6-2.0
Patch foraging total patch changes 18 sec0.71.12.2-1.2-1.2-1.4-0.9-1.1-1.0-0.9-1.4-1.5-1.20.20.3-0.3-0.8
Patch foraging total patch changes 24 sec0.91.62.3-1.3-1.3-1.5-1.3-1.4-1.4-1.2-1.5-1.5-1.31.21.1-0.5-0.2
Patch foraging total patch changes 6 sec1.31.93.8-1.7-1.5-1.9-1.1-1.5-1.3-0.8-1.9-1.9-1.70.50.1-0.9-1.1
Patch foraging time to switch 0 sec0.10.20.4-0.4-0.5-0.5-0.3-0.5-0.4-0.3-0.7-0.6-0.60.2-0.10.0-0.3
Patch foraging water rate 0 sec0.40.92.50.71.10.90.71.00.80.51.21.11.3-0.2-0.10.41.6
Patch foraging water rate 12 sec0.40.73.8-0.3-0.0-0.2-0.8-0.4-0.7-0.9-0.1-0.2-0.21.21.4-1.01.9
Patch foraging water rate 18 sec0.71.06.20.61.00.90.30.80.5-0.11.21.11.20.80.7-0.42.5
Patch foraging water rate 24 sec0.60.82.4-0.6-0.4-0.4-0.9-0.6-0.8-1.3-0.3-0.5-0.41.51.5-0.91.0
Patch foraging water rate 6 sec0.40.62.4-0.10.20.3-0.40.1-0.2-0.60.50.40.51.41.3-0.71.6
Seeking ratio, delayed vs. immediate footshock0.10.10.3-0.3-0.0-0.3-0.2-0.2-0.20.0-0.3-0.3-0.20.20.0-0.10.6
Distance traveled before self-admin0.20.32.50.40.60.50.00.20.10.00.50.50.20.20.4-0.61.6
Distance traveled after self-admin1.51.83.2-1.4-1.3-1.1-1.5-1.3-1.4-1.6-1.0-1.1-1.11.61.8-1.70.1
Extensor digitorum longus weight3.011.717.03.54.03.13.73.33.53.92.92.82.9-4.1-4.03.32.2
Bone: elastic displacement1.31.52.11.41.11.41.21.31.31.31.41.41.3-1.4-1.01.1-0.5
Bone: elastic work0.60.81.90.90.90.81.00.90.91.10.80.80.8-1.4-1.10.6-0.2
Bone: endosteal estimation0.20.41.50.30.50.50.70.50.70.70.40.50.4-1.2-1.10.0-0.5
Bone: endosteal perimeter0.00.10.5-0.00.10.00.20.10.20.5-0.00.10.1-0.7-0.6-0.2-0.3
Epididymis fat weight14.951.259.7-7.6-7.7-7.6-7.7-7.7-7.7-7.6-7.5-7.5-7.47.27.0-5.9-2.1
Delta time in closed arm before/after self-admin0.30.21.5-0.5-0.6-0.6-0.2-0.3-0.2-0.3-0.4-0.6-0.1-0.3-0.10.2-1.2
Delta time in open arm before/after self-admin0.10.10.20.30.10.10.30.10.20.3-0.00.1-0.0-0.4-0.50.4-0.4
Diff in mean of infusions in LGA sessions0.10.10.2-0.3-0.3-0.2-0.1-0.2-0.1-0.0-0.3-0.2-0.2-0.4-0.20.5-0.4
Delay discount exponential model param0.10.10.2-0.4-0.3-0.3-0.4-0.3-0.3-0.5-0.3-0.2-0.40.40.4-0.10.3
Extinction: sum of active levers before priming0.80.94.40.7-0.10.90.70.80.80.30.70.71.0-0.5-0.61.5-2.1
Active lever presses in extinction session 61.61.62.51.21.01.41.41.41.41.21.31.41.6-1.0-1.31.2-0.9
Bone: final force0.00.10.4-0.3-0.2-0.2-0.1-0.1-0.1-0.0-0.2-0.3-0.1-0.2-0.2-0.2-0.7
Bone: final moment0.00.10.5-0.3-0.2-0.1-0.0-0.1-0.00.0-0.2-0.3-0.1-0.3-0.2-0.2-0.7
Food consumed during 24 hour testing period0.00.10.10.10.1-0.4-0.0-0.2-0.10.2-0.4-0.3-0.3-0.4-0.30.10.2
Glucose0.60.91.4-1.1-1.0-1.2-1.0-1.1-1.0-0.8-1.2-1.1-1.20.40.6-0.8-0.3
Heart weight2.03.15.9-1.8-2.1-1.3-1.9-1.6-1.8-2.2-1.2-1.2-1.32.42.3-1.6-1.0
Delay discount hyperbolic model param0.10.10.5-0.10.1-0.1-0.2-0.1-0.1-0.3-0.00.0-0.20.30.3-0.00.7
Intermittent access intake day 1-15 change0.40.81.91.01.11.00.70.90.70.61.11.20.9-0.4-0.20.31.4
Intermittent access intake escalation0.20.31.40.60.70.60.30.50.40.30.70.80.6-0.00.1-0.01.2
Intermittent access intake escalation 20.10.21.60.20.50.30.00.1-0.0-0.00.20.20.10.00.2-0.31.3
Intermitt. access day 1 inactive lever presses0.41.63.01.41.01.11.41.31.31.51.11.11.2-1.2-1.41.70.0
Intermitt. access day 15 inactive lever presses1.73.46.91.91.41.32.01.61.92.31.21.21.5-2.5-2.62.4-0.9
Intermitt. access escalation Index2.53.56.7-2.2-2.0-2.5-1.8-2.2-1.9-1.7-2.6-2.4-2.40.80.7-0.7-0.7
Intermittent access day 1 total infusions3.04.96.72.62.52.32.42.22.32.52.12.11.9-2.3-2.42.00.8
Intermittent access day 15 total infusions2.23.34.42.12.12.01.91.91.91.82.02.11.8-1.5-1.51.41.1
Intermittent access terminal intake (last 3 days)3.34.46.12.42.52.32.22.22.22.12.22.32.1-1.8-1.81.71.3
Intermittent access total infusions4.24.96.82.62.52.52.32.42.32.22.42.52.3-1.9-1.91.70.9
Intermittent access day 1 locomotion2.32.94.71.91.41.91.81.81.81.81.81.71.7-1.5-1.62.2-0.1
Intermittent access day 15 total locomotion0.20.41.11.00.50.50.60.50.50.80.40.60.2-0.7-0.71.10.0
Intermittent access total locomotion1.31.53.11.60.81.41.21.21.21.11.31.51.2-0.9-0.91.7-0.5
Intermittent access standard deviation1.02.12.91.71.31.71.51.51.51.51.51.61.3-1.4-1.31.40.2
Left kidney weight0.10.30.90.20.10.50.30.60.5-0.10.80.81.00.20.10.2-0.8
Right kidney weight0.21.02.5-1.0-1.2-0.4-1.0-0.6-0.8-1.5-0.3-0.2-0.31.61.5-1.0-1.2
Cocaine induced anxiety0.20.32.50.2-0.20.20.30.30.30.30.10.20.3-0.5-0.50.8-1.6
Post-drug Anxiety1.71.82.9-1.4-1.7-1.4-1.4-1.4-1.4-1.3-1.3-1.3-1.21.31.3-1.0-1.1
Baseline Anxiety3.23.74.5-2.0-1.7-2.1-2.1-2.1-2.1-1.9-2.0-2.0-2.01.91.9-2.00.5
Tail length0.10.61.9-0.6-0.3-0.2-0.7-0.3-0.5-1.00.1-0.10.21.31.4-1.20.7
Length with tail0.62.87.8-1.7-1.6-0.9-1.8-1.1-1.5-2.3-0.5-0.7-0.42.62.8-2.2-0.3
Length without tail0.20.81.9-1.2-1.1-0.4-0.8-0.4-0.6-1.3-0.1-0.20.21.31.4-1.1-1.0
Times rat made contact with spout0.81.02.11.11.00.81.10.91.01.10.70.70.7-1.5-1.21.00.5
Lifetime Intake4.55.57.82.82.42.72.52.52.52.32.62.72.4-2.0-2.12.10.3
Liver weight, left2.74.57.3-2.3-2.3-1.8-2.3-2.0-2.1-2.4-1.7-1.8-1.72.72.5-2.3-1.2
Liver weight, right5.49.518.3-3.0-3.6-2.5-3.3-2.8-3.1-3.8-2.3-2.3-2.34.33.9-2.5-2.2
Locomotor activity0.81.25.4-0.9-1.7-1.0-0.9-0.9-0.8-1.0-1.0-1.0-0.90.60.60.1-2.3
Locomotor testing distance0.30.52.6-0.2-0.8-0.6-0.1-0.4-0.2-0.1-0.7-0.7-0.7-0.6-0.60.7-1.6
Locomotor testing rearing0.61.22.90.90.40.71.10.91.11.00.60.60.7-1.5-1.61.7-1.5
Locomotion in novel chamber0.00.00.1-0.10.1-0.2-0.1-0.2-0.1-0.1-0.3-0.3-0.30.2-0.00.00.4
Locomotion in novel chamber post-restriction2.43.94.7-2.1-2.2-2.1-2.1-2.0-2.0-2.1-2.0-2.1-2.01.91.8-1.3-1.4
Fecal boli incidents, locomotor time 11.11.63.01.31.51.51.11.51.30.81.61.71.7-0.5-0.60.91.0
Change in fecal boli incidents, locomotor task3.93.95.1-2.1-2.3-2.0-2.1-2.0-2.1-2.1-1.9-2.0-1.71.92.0-1.9-1.2
Time >=10cm from walls, locomotor time 10.20.20.50.50.30.50.10.50.30.10.70.70.70.40.40.0-0.2
Bouts of movement, locomotor time 10.70.85.50.31.0-0.00.60.20.40.8-0.1-0.2-0.1-1.1-1.20.22.3
Total resting periods, locomotor time 10.91.06.50.31.2-0.00.70.30.50.9-0.1-0.20.0-1.3-1.30.22.5
Rest time, locomotor task time 10.30.31.9-0.50.1-0.5-0.3-0.4-0.4-0.1-0.5-0.5-0.60.10.1-1.01.4
Distance moved, locomotor task time 10.50.85.0-0.4-1.1-0.3-0.7-0.5-0.6-1.0-0.2-0.2-0.11.11.10.0-2.2
Vertical activity count, locomotor time 10.10.41.7-0.3-0.6-0.3-0.5-0.4-0.4-0.7-0.2-0.4-0.10.80.8-0.2-1.3
Time >=10cm from walls, locomotor time 20.81.12.01.21.01.41.01.21.11.01.41.31.3-0.4-0.41.0-0.5
Bouts of movement, locomotor time 20.40.62.6-0.7-0.3-0.8-0.7-0.7-0.7-0.7-0.7-0.8-0.50.50.7-0.91.6
Total resting periods, locomotor time 20.40.64.3-0.6-0.0-0.8-0.5-0.6-0.6-0.4-0.8-0.8-0.50.10.3-0.82.1
Rest time, locomotor task time 20.40.52.60.30.90.00.60.20.40.8-0.10.1-0.1-1.2-1.10.21.6
Distance moved, locomotor task time 20.50.65.0-0.1-0.90.0-0.5-0.2-0.3-0.60.1-0.10.01.10.90.3-2.2
Vertical activity count, locomotor time 20.20.32.00.1-0.40.3-0.20.2-0.0-0.30.40.20.40.80.7-0.1-1.4
Light reinforcement 10.92.25.71.01.51.01.61.21.51.60.80.91.1-2.4-2.21.31.8
Light reinforcement 21.32.03.91.21.81.21.41.31.41.41.11.11.2-1.9-1.60.82.0
Bone: marrow area0.20.41.50.30.50.50.70.50.70.70.40.50.4-1.2-1.10.1-0.4
Bone: maximum diameter0.20.31.90.00.30.10.50.20.40.6-0.10.00.0-1.4-1.2-0.10.1
Bone: maximum force0.00.00.20.00.10.00.20.10.20.30.10.00.1-0.4-0.30.1-0.4
Bone: maximum moment0.00.10.30.10.20.10.30.20.30.40.10.10.2-0.5-0.50.1-0.4
Mean time between licks in bursts1.12.74.0-1.6-1.8-1.5-1.8-1.6-1.7-1.9-1.4-1.3-1.42.01.9-1.6-1.0
Mean num. licks in bursts0.91.32.61.11.31.41.01.31.10.91.41.41.4-0.7-0.50.31.6
Cd content in liver0.00.00.1-0.2-0.3-0.0-0.1-0.1-0.1-0.3-0.1-0.0-0.1-0.20.00.1-0.2
Co content in liver4.95.67.12.52.42.42.52.62.62.52.52.72.6-2.5-2.21.90.5
Cu content in liver0.30.40.50.70.40.70.60.70.60.70.70.70.7-0.2-0.40.7-0.6
Fe content in liver2.12.54.81.40.91.61.61.61.71.61.51.61.5-1.2-1.61.7-2.2
K content in liver0.20.21.5-0.7-0.6-0.4-0.2-0.3-0.1-0.0-0.4-0.1-0.3-0.3-0.3-0.6-1.2
Mg content in liver0.40.43.6-0.7-0.7-0.2-0.0-0.00.1-0.1-0.10.30.1-0.4-0.3-0.1-1.9
Mn content in liver0.50.61.3-1.1-0.9-1.0-0.4-0.8-0.5-0.3-1.1-0.7-0.8-0.5-0.4-0.4-0.9
Na content in liver1.41.52.51.31.11.41.21.41.31.31.61.61.6-0.6-0.80.8-0.5
Rb content in liver0.40.44.0-0.7-0.9-0.4-0.2-0.3-0.2-0.2-0.4-0.3-0.2-0.0-0.2-0.2-2.0
Se content in liver0.30.43.2-0.5-0.8-0.4-0.3-0.4-0.3-0.2-0.4-0.2-0.40.2-0.00.5-1.8
Sr content in liver0.10.10.50.30.30.2-0.10.1-0.0-0.00.30.30.30.50.6-0.40.7
Zn content in liver0.91.01.7-1.2-1.3-1.0-1.0-0.9-0.9-1.0-0.8-0.5-0.61.01.1-1.0-1.1
Bone: minimum diameter0.40.71.4-1.2-0.9-1.0-0.8-0.9-0.8-0.8-1.0-0.9-0.90.30.4-1.1-0.4
Time in familiar zone, hab. session 10.90.91.4-1.2-1.2-0.8-0.9-0.9-0.9-1.1-0.9-0.9-0.80.70.8-0.9-1.0
Time in novel zone, hab. session 10.20.20.3-0.3-0.4-0.5-0.4-0.4-0.4-0.4-0.5-0.4-0.50.50.3-0.30.5
Total zone transitions, hab. session 10.20.21.10.30.50.50.30.40.40.20.50.40.4-0.3-0.10.31.0
Total locomotion distance, hab. session 10.30.51.00.70.51.00.60.80.70.41.01.01.0-0.4-0.20.5-0.3
Locomotion velocity, hab. session 10.91.31.91.21.01.41.11.31.21.01.41.31.4-1.0-0.81.0-0.3
Time in familiar zone, hab. session 20.10.20.4-0.4-0.4-0.6-0.3-0.5-0.4-0.3-0.6-0.5-0.5-0.20.10.10.2
Time in novel zone, hab. session 20.20.20.6-0.4-0.5-0.1-0.3-0.2-0.3-0.4-0.1-0.1-0.10.80.5-0.7-0.7
Total zone transitions, hab. session 20.20.31.4-0.60.1-0.4-0.3-0.4-0.3-0.2-0.5-0.5-0.5-0.1-0.0-0.71.2
Total locomotion distance, hab. session 20.20.21.0-0.50.1-0.5-0.2-0.4-0.3-0.0-0.6-0.5-0.5-0.2-0.1-0.41.0
Locomotion velocity, hab. session 20.10.21.1-0.30.3-0.3-0.0-0.2-0.10.2-0.4-0.4-0.4-0.4-0.3-0.21.0
Novel to familiar place preference ratio0.80.91.6-1.1-0.9-0.8-1.0-0.8-0.9-1.2-0.7-0.7-0.71.31.2-1.10.5
Novelty place preference1.31.42.2-1.3-1.1-1.0-1.2-1.1-1.2-1.5-0.9-0.9-0.91.51.4-1.30.5
Time in novel zone, NPP test1.21.32.5-1.3-1.1-0.9-1.2-1.1-1.2-1.5-0.9-0.9-0.91.61.4-1.30.3
Total zone transitions, NPP test1.01.42.31.11.51.21.31.21.21.31.11.21.1-1.1-1.21.10.9
Total locomotion distance, NPP test1.31.82.51.31.61.31.51.41.41.51.21.31.3-1.4-1.51.30.9
Locomotion velocity, NPP test1.92.73.81.51.91.61.81.61.71.91.51.51.5-1.9-1.81.50.9
Intraocular pressure5.27.511.2-2.9-3.4-2.6-2.9-2.8-2.8-3.1-2.6-2.5-2.52.82.8-2.4-2.1
Delta distance traveled before/after self-admin2.22.33.6-1.6-1.8-1.8-1.6-1.6-1.6-1.5-1.7-1.9-1.51.41.2-1.0-0.9
Delta ambulatory time before/after self-admin0.60.71.3-1.0-1.1-1.0-0.8-0.8-0.8-0.8-1.0-1.1-0.70.50.4-0.4-1.1
Parametrial fat weight15.736.945.4-6.5-5.6-6.7-6.6-6.7-6.7-6.1-6.6-6.5-6.75.75.9-5.61.2
Pavlov. Cond. lever latency0.60.81.7-0.8-0.7-0.8-1.0-0.8-0.9-1.1-0.7-0.8-0.71.31.2-0.80.5
Pavlov. Cond. magazine entry latency0.10.10.8-0.2-0.4-0.10.0-0.1-0.00.1-0.2-0.1-0.1-0.1-0.3-0.0-0.9
Pavlov. Cond. change in total contacts0.10.10.90.0-0.20.30.20.20.20.20.20.30.2-0.1-0.1-0.0-1.0
Pavlov. Cond. index score0.20.21.20.1-0.10.30.40.30.40.50.20.20.2-0.7-0.70.3-1.1
Pavlov. Cond. latency score0.10.20.90.0-0.10.20.40.20.30.50.00.10.1-0.7-0.70.2-1.0
Pavlov. Cond. lever contacts0.50.51.00.60.50.80.80.70.80.90.70.80.7-1.0-0.90.4-0.6
Pavlov. Cond. magazine entry number0.10.10.5-0.10.1-0.2-0.3-0.2-0.3-0.5-0.0-0.1-0.10.50.6-0.20.7
Pavlov. Cond. intertrial magazine entries1.92.33.81.91.41.61.51.61.61.51.61.61.7-1.1-1.32.0-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.30.50.40.70.80.70.80.90.60.60.6-1.1-1.10.6-0.9
Pavlov. Cond. response bias0.70.91.40.80.61.01.00.91.01.10.90.90.9-1.1-1.20.7-0.9
Pavlov. Cond. lever latency1.11.53.7-1.5-1.7-0.9-1.2-1.0-1.1-1.4-0.9-0.8-0.81.11.2-1.0-1.9
Pavlov. Cond. magazine entry latency0.20.32.30.40.6-0.30.1-0.00.00.5-0.2-0.3-0.2-0.4-0.4-0.01.5
Pavlov. Cond. change in total contacts0.30.62.30.91.10.20.60.40.40.90.1-0.00.1-0.9-0.80.71.5
Pavlov. Cond. index score0.81.14.01.21.50.50.90.70.81.20.50.40.5-1.0-1.10.72.0
Pavlov. Cond. latency score0.81.14.51.31.50.50.90.80.81.20.60.50.5-1.0-1.00.82.1
Pavlov. Cond. lever contacts0.71.02.71.21.40.61.00.80.91.10.70.60.6-0.9-1.00.91.6
Pavlov. Cond. magazine entry number0.10.21.0-0.2-0.30.40.00.20.1-0.30.40.50.40.30.2-0.1-1.0
Pavlov. Cond. intertrial magazine entries2.74.05.5-2.3-2.2-1.9-2.1-2.0-2.1-2.2-1.8-1.8-1.72.32.1-1.9-0.6
Pavlov. Cond. lever-magazine prob. diff.0.40.62.80.91.10.10.60.40.50.90.20.10.2-0.8-0.80.51.7
Pavlov. Cond. response bias1.01.42.71.51.60.81.21.01.11.50.80.70.7-1.2-1.31.01.6
Time in closed arm before self-admin0.30.40.8-0.6-0.8-0.5-0.8-0.7-0.8-0.9-0.6-0.4-0.80.80.90.1-0.1
Time in closed arm after self-admin0.80.91.3-0.8-1.1-0.9-1.0-1.1-1.0-1.0-1.0-1.0-1.20.80.8-0.2-0.6
Time in open arm before self-admin0.00.00.4-0.10.2-0.2-0.00.10.00.0-0.0-0.30.3-0.1-0.1-0.10.6
Time in open arm after self-admin0.50.61.10.80.60.60.90.70.80.80.50.60.5-1.0-1.10.9-0.3
Bone: periosteal estimation0.20.51.80.30.60.50.70.50.70.70.40.50.5-1.3-1.10.0-0.1
Bone: periosteal perimeter0.00.10.40.00.20.00.30.20.30.40.00.10.1-0.7-0.6-0.10.0
Bone: post-yield work1.52.22.81.61.51.61.51.71.61.51.61.61.7-1.2-1.21.60.3
Progressive ratio test 1 active lever presses2.63.24.72.11.72.21.92.01.91.82.02.11.9-1.5-1.61.40.1
Progressive ratio test 1 breakpoint2.73.34.82.11.72.21.92.02.01.82.12.11.9-1.5-1.61.50.1
Progressive ratio test 1 inactive lever presses4.36.28.83.02.12.72.72.72.72.62.62.72.6-2.2-2.42.5-0.8
Progressive ratio test 2 active lever presses2.12.44.21.91.62.01.51.81.61.22.12.02.0-0.7-0.80.70.4
Progressive ratio test 2 breakpoint1.92.24.01.81.51.91.41.71.51.12.01.91.9-0.6-0.70.60.5
Progressive ratio test 2 inactive lever presses2.33.75.52.31.82.22.02.12.11.92.22.22.1-1.6-1.61.7-0.3
Incentive Sensitization - Responses0.91.33.11.31.11.41.01.41.20.71.61.51.8-0.4-0.40.5-0.1
Incentive Sensitization - Breakpoint0.70.92.41.10.91.20.81.21.00.51.41.31.5-0.2-0.20.40.0
Sum of active levers in priming session hrs 5-60.40.42.7-0.4-0.7-0.5-0.1-0.3-0.1-0.0-0.6-0.6-0.2-0.3-0.50.7-1.6
Progressive ratio0.00.10.6-0.2-0.4-0.3-0.1-0.2-0.1-0.0-0.3-0.2-0.20.0-0.10.2-0.8
Food seeking constrained by brief footshock8.710.618.03.32.83.73.43.83.62.94.03.84.2-2.3-2.52.9-0.7
Seeking ratio, punishment vs. effort0.91.42.51.21.11.51.21.41.30.91.61.51.6-0.7-0.60.60.2
Retroperitoneal fat weight26.9114.8145.3-11.6-10.9-12.0-11.4-11.9-11.6-10.8-12.1-11.8-11.99.59.4-8.9-1.4
Reaction time number correct0.30.52.60.51.10.40.60.50.60.70.50.40.4-0.8-0.70.21.6
Reaction time mean minus median0.00.10.40.60.40.30.10.10.10.40.00.0-0.1-0.2-0.20.30.3
Reaction time mean minus median AUC0.00.00.10.1-0.2-0.1-0.2-0.3-0.3-0.1-0.3-0.3-0.30.10.20.1-0.1
Reaction time num false alarms1.11.52.9-1.6-1.4-1.6-1.1-1.4-1.2-1.0-1.7-1.7-1.50.20.2-0.90.0
Reaction time num false alarms AUC1.11.73.2-1.6-1.4-1.7-1.1-1.5-1.2-1.1-1.8-1.7-1.60.20.3-0.80.0
Reaction time trials correct on left0.30.52.60.51.10.40.60.50.60.70.50.40.4-0.8-0.70.21.6
Reaction time trials on left0.30.52.40.51.10.40.70.50.60.70.50.30.4-0.8-0.70.21.6
Reaction time mean0.40.62.0-0.4-0.8-0.1-0.8-0.5-0.7-0.9-0.1-0.1-0.21.41.4-0.7-1.2
Reaction time mean AUC0.30.51.8-0.3-0.70.0-0.7-0.4-0.6-0.9-0.0-0.0-0.11.31.2-0.7-1.2
Median of all reaction times0.60.92.6-0.5-1.0-0.1-0.9-0.5-0.7-1.1-0.0-0.1-0.11.61.6-0.8-1.6
Reaction time omissions0.10.21.6-0.2-0.5-0.1-0.1-0.3-0.1-0.1-0.4-0.4-0.4-0.1-0.30.2-1.3
Reaction time false alarm rate1.52.13.6-1.8-1.8-1.8-1.4-1.7-1.5-1.3-1.9-1.8-1.70.50.6-1.0-0.6
Reaction time premature initiation rate0.10.20.7-0.3-0.1-0.4-0.4-0.4-0.4-0.2-0.4-0.4-0.40.50.3-0.20.8
Reaction time premature initiations0.10.21.9-0.00.4-0.2-0.0-0.1-0.10.1-0.1-0.2-0.10.1-0.1-0.01.4
Std. dev. reaction times0.10.20.5-0.1-0.3-0.2-0.5-0.5-0.5-0.4-0.4-0.4-0.60.60.6-0.7-0.2
Reaction time trials completed0.30.52.40.51.10.40.70.50.60.70.50.30.4-0.8-0.70.21.6
Reaction time trials AUC0.30.72.80.61.20.50.80.60.70.80.50.40.4-0.9-0.90.31.7
Run reversals in cocaine runway, females0.40.41.70.60.80.70.30.60.40.20.80.80.60.20.2-0.41.3
Run reversals in cocaine runway, males0.60.61.00.80.90.90.70.80.70.61.00.90.9-0.3-0.1-0.00.8
Latency to leave start box in cocaine runway0.60.71.21.00.90.90.90.90.91.10.90.90.8-0.9-0.80.7-0.3
Latency to leave start box in cocaine runway, F0.20.20.60.50.20.30.40.30.40.50.30.30.3-0.5-0.40.8-0.7
Latency to leave start box in cocaine runway, M0.70.61.40.71.20.80.70.80.70.80.90.90.8-0.4-0.4-0.51.1
Std. dev. time between licks in bursts0.81.11.9-1.0-1.4-1.2-1.0-1.1-1.0-1.1-1.2-1.1-1.10.60.6-0.3-1.4
Total sessions with >9 infusions2.22.74.32.01.52.11.71.81.71.51.92.01.6-1.3-1.41.30.4
Short access day 1 total inactive lever presses5.97.710.43.21.93.03.02.82.92.82.72.72.4-2.9-3.13.1-2.0
Short access day 10 total inactive lever presses0.92.13.91.41.21.21.71.31.51.91.01.01.0-1.9-2.01.9-0.3
Short access day 1 total infusions4.56.08.52.92.12.72.72.52.62.62.52.52.1-2.6-2.72.3-0.6
Short access day 10 total infusions3.74.76.82.62.12.62.32.42.32.12.52.52.3-1.7-1.91.80.1
Short access total infusions2.63.34.92.21.62.21.91.91.91.62.02.01.8-1.5-1.61.8-0.3
Short access day 1 locomotion3.44.26.22.52.22.02.22.02.12.41.91.91.6-2.2-2.31.81.2
Short access day 10 total locomotion1.32.42.91.51.71.51.61.61.61.61.51.61.4-1.3-1.51.61.6
Short access total locomotion0.91.11.61.20.91.31.11.21.11.01.31.31.1-0.6-0.81.00.3
One hour access (0.3 mA shock)2.63.05.02.12.12.21.71.81.71.62.12.11.7-1.2-1.10.81.2
Compulsive drug intake2.02.43.3-1.7-1.8-1.5-1.6-1.7-1.7-1.7-1.7-1.6-1.81.31.3-1.1-0.7
One hour access (shock baseline)3.65.57.92.72.82.72.32.62.42.32.72.72.7-1.7-1.71.31.3
Social response proportion0.10.11.1-0.1-0.10.2-0.20.0-0.1-0.20.30.40.20.40.5-1.00.2
Social responses0.20.30.7-0.7-0.4-0.6-0.5-0.5-0.5-0.5-0.5-0.3-0.40.40.4-0.90.6
Social time0.10.10.6-0.1-0.10.1-0.20.1-0.1-0.40.30.30.20.60.6-0.30.8
Soleus weight3.39.713.33.33.63.13.33.23.23.42.92.92.9-3.5-3.22.91.9
Bone: stiffness0.00.00.2-0.2-0.1-0.3-0.2-0.2-0.2-0.1-0.3-0.4-0.20.20.10.10.3
Tibialis anterior weight1.86.211.22.33.12.02.72.22.53.01.71.71.7-3.3-3.22.32.2
Time to tail flick, vehicle, before self-admin0.10.20.4-0.3-0.2-0.3-0.4-0.2-0.3-0.6-0.1-0.10.10.70.7-0.60.3
Time to tail flick, vehicle, after self-admin3.04.06.3-1.9-1.7-2.1-2.2-2.3-2.3-1.9-2.2-1.9-2.51.72.0-2.10.4
Time to tail flick, test, before self-admin0.20.20.50.60.20.30.40.40.40.30.30.40.3-0.3-0.40.7-0.7
Time to tail flick, test, after self-admin0.90.91.80.91.21.00.71.00.80.51.21.41.2-0.3-0.20.41.3
Delta time to tail flick, vehicle, before/after SA0.80.82.4-0.8-0.6-1.1-0.8-1.2-1.0-0.5-1.3-1.2-1.50.10.3-0.60.4
Delta time to tail flick, test, before/after SA2.02.03.01.41.71.61.41.61.41.21.61.71.6-1.1-0.91.01.2
Tibia length1.64.57.7-2.3-2.5-1.5-2.3-1.8-2.0-2.7-1.4-1.4-1.32.82.7-2.6-1.4
Ambulatory time before self-admin0.20.32.00.50.70.60.20.30.20.10.60.70.30.10.3-0.21.4
Ambulatory time after self-admin0.80.92.0-1.0-1.1-0.6-1.1-0.8-1.0-1.2-0.6-0.6-0.61.41.4-1.1-0.3
Bone: tissue strength0.70.71.5-0.8-0.4-0.8-0.9-0.8-0.9-0.8-0.7-0.9-0.81.00.9-1.20.8
Total heroin consumption2.12.53.11.81.41.71.71.71.71.61.51.51.7-1.7-1.61.7-0.3
Bone: trabecular number2.03.44.91.71.82.02.02.02.12.01.91.91.9-2.2-2.10.9-0.1
Bone: trabecular spacing1.21.64.8-1.1-1.4-1.0-1.4-1.1-1.3-1.6-0.9-0.9-0.92.21.8-0.4-0.5
Bone: trabecular thickness0.30.41.10.40.40.60.70.60.70.70.60.70.6-1.1-0.80.1-0.6
Bone: trabecular tissue density0.30.51.01.00.60.70.70.70.70.70.70.60.5-0.5-0.60.9-0.4
Water consumed over 24 hours0.10.20.4-0.1-0.1-0.6-0.1-0.4-0.20.1-0.6-0.7-0.6-0.5-0.40.1-0.2
Number of responses in last shaping day1.01.12.11.40.81.21.01.21.10.71.41.11.4-0.7-0.70.5-0.8