Hub : Genes

Otof

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Otof 0.18 0.12 2.5e-08 0.13 0.16 0.16 0.15 2.7e-06 1.4e-07 2.3e-07 3.7e-07
2 PL intron excision ratio chr6_26022098_26023642 0.02 0.02 2.5e-03 0.01 0.01 0 0.01 2.9e-02 9.9e-03 8.0e-02 3.0e-02
3 IL gene expression Otof 0.27 0.17 2.1e-05 0.13 0.17 0.14 0.16 6.1e-04 7.8e-05 2.5e-04 1.1e-04
4 NAcc gene expression Otof 0.03 0.03 3.7e-05 0.02 0.03 0.02 0.02 1.3e-03 2.1e-04 1.1e-03 2.0e-03
5 NAcc alternative TSS XM_039113011.1 0.02 0.02 7.3e-03 0.01 0.01 0.01 0.01 3.3e-02 1.2e-02 2.4e-02 3.9e-02
6 PL gene expression Otof 0.14 0.08 0.0e+00 0.17 0.17 0.17 0.17 1.1e-18 3.7e-18 1.3e-18 3.9e-18
7 Brain gene expression Otof 0.41 0.12 0.0e+00 0.5 0.52 0.52 0.52 9.9e-53 1.3e-56 1.1e-55 1.8e-55
8 RMTg gene expression Otof 0.16 0.13 3.0e-03 0.12 0.05 0.12 0.09 3.8e-04 1.9e-02 3.5e-04 2.1e-03
9 OFC gene expression Otof 0.39 0.19 2.9e-07 0.29 0.26 0.27 0.27 1.2e-07 6.0e-07 4.1e-07 3.3e-07
10 Adipose gene expression Otof 0.03 0.03 2.3e-03 0.02 0.01 0.01 0.01 3.8e-03 8.4e-03 7.4e-03 8.2e-03
11 Brain mRNA stability Otof 0.07 0.06 2.3e-04 0.05 0.03 0.03 0.04 2.5e-05 1.3e-03 7.4e-04 9.9e-05
12 PL intron excision ratio chr6_26021480_26023642 0.03 0.02 6.3e-04 0.02 0.03 0.05 0.02 1.8e-03 4.1e-04 5.6e-06 1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density3.35.48.02.42.42.42.32.3-2.12.1-2.8-2.42.42.61.4
Area under the delay curve0.10.10.3-0.2-0.2-0.2-0.2-0.30.2-0.20.00.4-0.6-0.20.1
BMI with tail1.54.99.6-2.4-2.5-2.7-2.6-2.62.9-3.10.91.4-1.9-1.20.5
BMI without tail0.30.61.1-0.8-0.8-0.9-0.9-0.91.0-1.0-0.20.3-0.5-0.50.4
Body weight1.87.59.6-3.1-3.0-3.1-3.1-3.02.8-3.01.72.7-3.1-2.60.6
Weight adjusted by age0.60.74.6-0.3-0.4-0.5-0.5-0.50.6-0.71.3-0.20.50.4-2.2
Bone surface1.11.93.31.21.21.11.11.1-0.90.8-1.8-1.61.61.61.7
Bone volume1.62.74.41.71.71.61.61.6-1.61.5-2.1-1.61.61.71.4
Breakpoint value in progressive ratio session1.61.75.21.21.21.11.11.1-1.10.9-1.6-1.20.91.52.3
Number of licking bursts0.70.81.7-1.0-1.1-1.1-1.1-1.11.2-1.30.60.3-0.3-0.2-0.0
Context. condit. distance diff. score0.10.10.50.30.30.30.40.4-0.50.5-0.0-0.10.1-0.2-0.7
Locomotion velocity, session 10.60.61.9-0.7-0.7-0.8-0.8-0.80.9-1.00.20.4-0.6-0.21.4
Locomotion distance, session 10.60.81.40.80.70.70.70.7-0.60.5-1.0-1.21.11.11.2
Locomotion velocity, session 20.10.20.5-0.4-0.3-0.3-0.3-0.30.1-0.10.60.7-0.4-0.7-0.2
Locomotion distance, session 20.00.10.1-0.3-0.3-0.3-0.3-0.30.4-0.4-0.2-0.20.0-0.2-0.1
Locomotion velocity, session 30.50.51.60.60.50.50.40.4-0.10.1-0.2-1.11.31.0-1.1
Locomotion distance, session 30.30.31.10.20.20.10.10.10.2-0.3-0.7-1.11.00.8-0.3
Stereotopy head waving bouts, day 31.92.33.01.71.71.71.71.7-1.61.6-0.6-1.51.51.7-0.7
Stereotopy head waving duration, day 30.40.50.80.80.80.80.80.8-0.90.90.2-0.30.50.6-0.4
Locomotion velocity, session 70.30.31.00.30.20.20.10.10.1-0.2-0.3-0.90.80.9-1.0
Locomotion distance, session 70.40.51.4-0.7-0.8-0.9-0.9-0.91.1-1.2-0.1-0.20.1-0.10.1
Stereotopy head waving bouts, day 70.40.43.0-0.0-0.0-0.0-0.0-0.0-0.00.11.40.4-0.2-0.1-1.7
Stereotopy head waving duration, day 70.50.62.10.80.80.80.80.7-0.70.70.6-0.50.60.8-1.4
Locomotion velocity, session 80.40.50.80.70.80.80.80.8-0.80.9-0.4-0.70.60.4-0.2
Locomotion distance, session 80.20.41.00.50.50.60.60.6-0.60.7-0.3-0.60.50.2-1.0
Degree of sensitization distance0.90.91.0-1.0-1.0-1.0-1.0-1.00.9-0.90.71.0-1.0-1.00.3
Degree of sensitization stereotypy0.60.73.1-0.6-0.6-0.5-0.6-0.60.6-0.51.50.7-0.5-0.5-1.8
Conditioned locomotion3.23.84.72.22.12.22.12.1-2.02.1-1.3-2.02.12.00.1
Cocaine response after cond. corrected0.20.20.50.50.50.50.50.5-0.40.4-0.7-0.2-0.10.70.7
Cocaine response after cond. not corrected0.70.71.31.01.01.01.00.9-0.90.9-0.8-0.70.51.10.5
Cocaine response before conditioning1.92.33.51.71.71.71.71.7-1.71.7-0.7-1.61.91.2-0.3
Saline control response1.11.52.01.21.31.31.31.3-1.41.4-1.4-1.11.10.90.7
Bone: connectivity density3.04.78.82.12.01.91.91.9-1.61.5-3.0-2.42.42.52.4
Bone: cortical apparent density0.20.31.10.30.20.30.20.2-0.00.2-0.9-0.91.00.30.5
Bone: cortical area0.10.21.0-0.1-0.1-0.2-0.2-0.20.2-0.3-1.0-0.30.30.20.8
Bone: cortical porosity2.72.93.81.91.91.91.91.9-2.01.9-1.2-1.71.51.5-0.5
Bone: cortical porosity2.02.12.91.61.61.71.71.7-1.71.7-1.2-1.31.21.3-0.3
Bone: cortical thickness0.20.40.5-0.7-0.7-0.7-0.7-0.70.6-0.70.20.5-0.5-0.7-0.6
Bone: cortical thickness0.70.81.50.90.80.80.80.8-0.70.6-1.2-1.21.21.10.4
Bone: cortical tissue density0.20.20.90.20.10.20.10.10.00.1-0.8-0.80.90.20.5
Condit. Reinf. active minus inactive responses1.41.62.3-1.3-1.3-1.4-1.4-1.41.5-1.51.31.3-1.3-0.80.2
Condit. Reinf. active-inactive response ratio1.01.11.8-1.1-1.2-1.2-1.2-1.21.3-1.30.80.9-0.9-0.60.4
Condit. Reinf. active responses0.10.10.2-0.2-0.2-0.3-0.3-0.30.4-0.40.40.3-0.40.10.2
Condit. Reinf. inactive responses0.70.91.21.11.11.11.11.1-1.11.1-0.6-0.80.60.9-0.1
Incentive salience index mean0.10.20.3-0.3-0.4-0.4-0.4-0.40.5-0.50.30.4-0.50.10.5
Condit. Reinf. lever presses0.30.40.70.70.80.80.80.8-0.80.8-0.7-0.30.10.60.3
Condit. Reinf. active minus inactive responses2.32.95.71.91.71.61.61.6-1.21.1-0.8-2.22.42.4-0.7
Condit. Reinf. active-inactive response ratio0.70.71.11.01.00.90.90.9-0.80.8-0.0-0.90.81.1-0.2
Condit. Reinf. active responses1.82.55.81.71.51.41.41.3-1.00.9-0.5-2.12.32.4-1.3
Condit. Reinf. inactive responses0.91.12.71.00.90.80.80.7-0.50.3-0.5-1.41.61.7-1.2
Condit. Reinf. lever presses1.42.03.61.41.41.31.31.3-1.21.20.0-1.71.91.6-1.6
Condit. Reinf. lever reinforcers received1.72.35.31.61.41.31.31.3-0.90.8-0.5-2.12.32.3-1.4
Conditioned reinforcement - actives3.33.44.81.92.02.02.02.0-1.92.1-2.2-1.61.51.40.9
Conditioned reinforcement - inactives4.85.47.42.32.42.42.42.4-2.52.4-2.7-1.91.91.82.7
Conditioned locomotion2.32.84.61.81.92.01.91.9-1.92.1-1.5-1.31.31.10.0
Patch foraging indifference point 0 sec0.40.71.1-0.9-0.9-1.0-0.9-0.90.8-1.10.60.7-0.8-0.50.2
Patch foraging indifference point AUC0.80.92.50.60.50.30.30.40.0-0.2-1.4-1.31.31.41.6
Delay disc. indifference point, 0s delay2.72.96.5-1.7-1.6-1.5-1.5-1.51.2-1.11.52.5-2.6-2.20.3
Delay disc. indifference point, 16s delay0.10.11.0-0.1-0.2-0.2-0.2-0.20.2-0.30.2-0.30.10.1-1.0
Delay disc. indifference point, 2s delay0.30.40.8-0.6-0.5-0.5-0.5-0.50.4-0.30.80.9-0.9-0.8-0.5
Delay disc. indifference point, 24s delay1.51.42.61.31.31.41.41.4-1.61.6-0.8-0.60.80.70.8
Delay disc. indifference point, 4s delay0.20.20.7-0.5-0.5-0.5-0.5-0.50.5-0.50.00.5-0.8-0.20.3
Delay disc. indifference point, 8s delay0.00.00.10.00.00.10.10.0-0.00.10.00.3-0.2-0.0-0.1
Indifference point function ln k0.70.92.60.91.01.11.11.1-1.51.6-0.1-0.1-0.0-0.0-0.7
Indifference point function log k0.70.92.60.91.01.11.11.1-1.51.6-0.1-0.1-0.0-0.0-0.7
Patch foraging total patch changes 0 sec0.40.61.1-0.9-0.9-1.0-0.9-0.90.8-1.10.50.7-0.7-0.50.4
Patch foraging total patch changes 12 sec0.91.21.6-1.2-1.2-1.3-1.2-1.21.1-1.20.91.2-0.9-1.00.5
Patch foraging total patch changes 18 sec0.50.71.5-0.8-0.8-1.0-0.9-0.91.0-1.20.10.3-0.3-0.01.1
Patch foraging total patch changes 24 sec1.01.32.1-1.2-1.2-1.2-1.2-1.21.2-1.31.41.2-0.7-0.9-0.3
Patch foraging total patch changes 6 sec0.91.33.4-1.1-1.2-1.4-1.4-1.31.6-1.80.70.4-0.4-0.2-0.1
Patch foraging time to switch 0 sec0.10.20.4-0.4-0.4-0.4-0.5-0.50.6-0.60.50.00.20.0-0.2
Patch foraging water rate 0 sec0.50.71.80.80.91.01.01.1-1.31.3-0.7-0.40.20.1-0.2
Patch foraging water rate 12 sec0.40.72.6-0.7-0.7-0.5-0.6-0.60.3-0.10.60.7-0.1-1.6-1.6
Patch foraging water rate 18 sec0.50.61.80.40.60.70.70.8-1.31.30.20.5-0.1-0.9-0.9
Patch foraging water rate 24 sec0.40.62.4-0.9-0.8-0.7-0.7-0.60.3-0.20.21.0-0.9-1.6-0.5
Patch foraging water rate 6 sec0.30.42.0-0.4-0.2-0.1-0.1-0.1-0.40.50.70.9-0.7-1.4-0.6
Seeking ratio, delayed vs. immediate footshock0.00.00.00.0-0.0-0.0-0.0-0.0-0.0-0.2-0.2-0.2-0.1-0.0-0.2
Distance traveled before self-admin0.30.33.00.20.20.40.30.3-0.30.60.0-0.20.10.1-1.7
Distance traveled after self-admin0.70.82.0-0.8-0.7-0.7-0.7-0.70.4-0.40.91.4-1.4-1.0-0.6
Extensor digitorum longus weight2.911.316.33.53.43.33.33.2-2.82.7-3.9-4.04.04.00.6
Bone: elastic displacement1.31.41.91.41.41.41.41.3-1.31.4-1.2-0.90.91.10.4
Bone: elastic work0.60.81.31.00.90.90.90.9-0.80.7-1.0-0.90.91.10.6
Bone: endosteal estimation0.40.85.20.50.50.40.40.5-0.40.2-1.3-0.70.80.82.3
Bone: endosteal perimeter0.10.21.80.10.10.00.10.1-0.1-0.1-0.8-0.30.30.41.4
Epididymis fat weight14.132.839.2-6.1-6.2-6.2-6.2-6.26.3-6.05.25.4-5.5-5.5-3.3
Delta time in closed arm before/after self-admin0.40.42.2-0.5-0.5-0.6-0.6-0.50.3-0.7-0.10.3-0.1-0.11.5
Delta time in open arm before/after self-admin0.30.21.00.40.40.40.40.3-0.10.2-1.0-0.80.40.60.3
Diff in mean of infusions in LGA sessions0.30.31.30.30.30.30.30.3-0.20.1-0.8-0.60.20.71.1
Delay discount exponential model param0.00.00.1-0.0-0.0-0.0-0.00.00.00.00.1-0.10.3-0.1-0.1
Extinction: sum of active levers before priming1.11.15.40.70.70.70.70.7-0.80.6-1.8-0.80.70.52.3
Active lever presses in extinction session 61.81.73.31.31.31.31.31.3-1.41.2-1.7-1.10.81.01.8
Bone: final force0.10.21.1-0.1-0.1-0.1-0.1-0.10.1-0.2-0.9-0.30.40.11.1
Bone: final moment0.10.21.4-0.0-0.0-0.1-0.1-0.10.1-0.2-0.9-0.30.40.21.2
Food consumed during 24 hour testing period0.20.21.3-0.2-0.2-0.2-0.2-0.20.3-0.31.20.2-0.10.2-0.6
Glucose0.20.30.5-0.6-0.6-0.6-0.6-0.60.6-0.60.50.4-0.7-0.30.1
Heart weight6.49.113.7-3.2-3.1-2.9-2.9-2.92.6-2.33.33.6-3.3-3.7-2.1
Delay discount hyperbolic model param0.00.00.10.00.00.00.00.1-0.10.10.1-0.20.3-0.1-0.2
Intermittent access intake day 1-15 change1.01.02.11.01.01.11.11.2-1.41.5-1.0-0.60.60.40.5
Intermittent access intake escalation0.50.51.20.60.70.80.80.8-1.01.1-0.8-0.40.40.20.5
Intermittent access intake escalation 20.10.10.2-0.4-0.4-0.3-0.3-0.30.2-0.1-0.20.3-0.4-0.5-0.1
Intermitt. access day 1 inactive lever presses0.20.21.20.30.30.20.20.2-0.20.1-1.1-0.80.70.3-0.2
Intermitt. access day 15 inactive lever presses3.94.39.02.12.01.81.81.8-1.41.1-2.1-3.02.82.90.2
Intermitt. access escalation Index1.71.52.9-1.3-1.3-1.4-1.4-1.41.7-1.71.20.7-0.9-0.40.3
Intermittent access day 1 total infusions4.24.96.22.42.42.32.32.3-2.12.0-2.2-2.52.42.40.0
Intermittent access day 15 total infusions3.54.05.22.12.12.22.22.2-2.32.2-2.2-1.81.71.60.9
Intermittent access terminal intake (last 3 days)3.13.44.42.02.02.02.02.0-2.12.0-1.9-1.81.71.40.5
Intermittent access total infusions4.24.66.12.32.32.42.42.4-2.52.4-2.3-1.91.91.61.1
Intermittent access day 1 locomotion2.42.53.61.61.61.61.61.6-1.51.5-1.9-1.71.61.40.8
Intermittent access day 15 total locomotion0.80.82.20.90.80.80.80.8-0.60.7-1.5-1.21.10.90.3
Intermittent access total locomotion1.11.23.71.01.01.11.01.0-1.01.1-1.9-1.21.00.70.9
Intermittent access standard deviation0.80.82.80.80.80.80.80.8-0.80.9-1.7-0.90.80.60.2
Left kidney weight0.20.61.70.60.80.80.90.9-1.21.3-0.50.20.1-0.20.0
Right kidney weight0.51.54.0-1.2-1.0-0.9-0.9-0.90.5-0.31.32.0-1.7-2.0-0.5
Cocaine induced anxiety0.30.41.70.40.40.30.30.3-0.20.1-1.0-0.80.70.61.3
Post-drug Anxiety1.31.41.8-1.3-1.3-1.3-1.3-1.31.2-1.20.41.2-1.3-1.30.5
Baseline Anxiety2.22.33.5-1.4-1.4-1.4-1.4-1.41.2-1.21.91.8-1.8-1.5-1.8
Tail length0.10.20.60.30.40.40.40.5-0.70.8-0.50.0-0.0-0.40.3
Length with tail0.51.74.4-1.3-1.1-1.0-1.0-1.00.4-0.41.22.0-2.0-2.10.3
Length without tail0.40.92.4-0.9-0.8-0.8-0.7-0.70.3-0.41.21.5-1.5-1.30.5
Times rat made contact with spout0.70.81.50.90.90.90.90.9-0.70.7-0.4-1.01.01.2-1.1
Lifetime Intake5.25.97.42.62.62.62.62.6-2.62.6-2.7-2.22.12.01.4
Liver weight, left1.32.13.5-1.5-1.5-1.4-1.4-1.51.4-1.21.41.8-1.9-1.5-0.0
Liver weight, right6.911.416.7-3.7-3.6-3.5-3.5-3.43.0-3.03.13.8-3.8-4.1-0.6
Locomotor activity0.81.35.9-1.0-0.9-1.0-0.9-0.90.9-1.0-0.01.0-1.4-0.72.4
Locomotor testing distance0.20.31.7-0.3-0.4-0.4-0.4-0.50.8-0.8-0.1-0.2-0.20.41.3
Locomotor testing rearing1.01.65.51.11.11.01.01.0-0.80.6-1.3-1.21.21.62.3
Locomotion in novel chamber0.40.51.0-0.8-0.8-0.8-0.8-0.80.7-0.70.20.4-0.8-1.00.1
Locomotion in novel chamber post-restriction2.22.74.1-1.8-1.8-1.9-1.9-1.81.9-2.00.81.3-1.3-1.41.2
Fecal boli incidents, locomotor time 11.71.83.41.31.51.51.51.6-1.81.8-1.4-0.80.80.51.0
Change in fecal boli incidents, locomotor task3.93.76.1-2.0-2.0-2.0-2.0-2.01.8-1.81.62.3-2.5-2.00.4
Time >=10cm from walls, locomotor time 10.20.20.70.30.40.40.40.4-0.70.7-0.20.2-0.1-0.30.8
Bouts of movement, locomotor time 11.21.39.10.60.50.40.40.3-0.1-0.00.5-1.31.51.3-3.0
Total resting periods, locomotor time 11.41.610.50.70.60.50.50.4-0.20.00.7-1.51.41.5-3.2
Rest time, locomotor task time 10.60.66.00.30.20.20.20.2-0.00.11.1-0.30.20.5-2.4
Distance moved, locomotor task time 10.80.94.6-0.8-0.7-0.7-0.7-0.60.4-0.4-0.21.0-1.0-1.22.1
Vertical activity count, locomotor time 10.50.51.0-0.7-0.7-0.6-0.6-0.60.4-0.50.10.8-0.9-1.01.0
Time >=10cm from walls, locomotor time 20.91.01.91.01.11.21.11.1-1.31.4-0.9-0.50.60.40.6
Bouts of movement, locomotor time 21.01.04.7-0.8-0.8-0.8-0.8-0.80.7-0.81.70.5-0.0-0.6-2.2
Total resting periods, locomotor time 21.11.27.1-0.7-0.7-0.8-0.8-0.80.8-0.91.80.30.2-0.3-2.7
Rest time, locomotor task time 20.80.97.10.50.30.30.30.20.1-0.10.8-1.00.71.2-2.7
Distance moved, locomotor task time 20.60.75.5-0.2-0.1-0.1-0.1-0.1-0.20.3-0.70.7-0.8-1.02.3
Vertical activity count, locomotor time 20.30.42.20.20.30.30.30.4-0.70.7-0.40.5-0.5-0.61.5
Light reinforcement 11.22.15.71.51.41.21.31.3-1.10.7-1.2-2.01.82.40.3
Light reinforcement 21.21.62.91.51.41.31.41.4-1.31.1-0.5-1.31.41.70.4
Bone: marrow area0.40.85.00.50.50.40.50.5-0.40.2-1.2-0.80.80.82.2
Bone: maximum diameter0.30.51.70.30.30.20.20.2-0.1-0.2-1.2-0.80.90.91.3
Bone: maximum force0.10.21.5-0.1-0.1-0.2-0.2-0.10.1-0.2-0.8-0.10.1-0.01.2
Bone: maximum moment0.10.21.7-0.0-0.0-0.1-0.1-0.10.1-0.1-0.8-0.10.20.11.3
Mean time between licks in bursts2.13.03.8-1.9-1.8-1.8-1.8-1.81.6-1.51.91.9-1.9-1.9-0.2
Mean num. licks in bursts0.81.01.91.11.21.21.21.2-1.31.4-0.4-0.40.40.4-0.7
Cd content in liver0.20.20.5-0.4-0.5-0.5-0.5-0.50.5-0.70.50.4-0.3-0.20.7
Co content in liver4.35.06.32.52.52.52.52.5-2.42.5-1.2-2.32.12.40.0
Cu content in liver0.20.22.10.30.30.30.30.3-0.30.2-0.4-0.10.10.31.5
Fe content in liver0.50.64.70.30.40.30.30.4-0.40.3-1.0-0.30.30.32.2
K content in liver1.31.22.1-1.2-1.2-1.3-1.3-1.21.3-1.50.90.7-1.0-0.50.9
Mg content in liver1.41.53.1-1.3-1.3-1.4-1.3-1.21.2-1.50.30.9-1.2-0.61.8
Mn content in liver0.30.31.2-0.0-0.1-0.2-0.2-0.20.5-0.7-0.3-0.80.71.1-0.2
Na content in liver1.11.12.11.11.21.21.21.2-1.41.3-0.9-0.40.20.71.0
Rb content in liver0.40.52.6-0.5-0.6-0.7-0.6-0.60.6-0.8-0.00.2-0.3-0.01.6
Se content in liver0.70.92.9-0.9-0.9-1.0-1.0-0.91.0-1.20.20.5-0.5-0.41.7
Sr content in liver0.40.41.1-0.4-0.4-0.3-0.3-0.30.2-0.10.90.8-1.0-0.7-0.7
Zn content in liver1.61.82.5-1.4-1.4-1.4-1.4-1.41.2-1.31.61.3-1.4-1.30.2
Bone: minimum diameter0.40.71.4-0.9-0.9-0.9-0.9-0.90.8-1.0-0.30.6-0.6-0.61.2
Time in familiar zone, hab. session 11.01.02.5-0.9-0.9-0.9-0.9-0.90.8-0.90.51.1-1.1-0.81.6
Time in novel zone, hab. session 10.40.42.6-0.4-0.4-0.4-0.4-0.40.5-0.40.4-0.10.0-0.4-1.6
Total zone transitions, hab. session 10.10.10.20.30.30.40.40.4-0.40.5-0.1-0.10.3-0.00.2
Total locomotion distance, hab. session 10.40.61.10.80.80.90.90.9-1.01.1-0.2-0.30.40.2-1.0
Locomotion velocity, hab. session 10.91.32.11.31.31.31.31.3-1.31.4-0.7-0.90.90.8-0.9
Time in familiar zone, hab. session 20.20.20.4-0.4-0.4-0.5-0.5-0.50.5-0.60.50.2-0.10.00.1
Time in novel zone, hab. session 20.10.10.4-0.2-0.2-0.2-0.2-0.20.1-0.1-0.10.3-0.4-0.60.1
Total zone transitions, hab. session 20.10.20.3-0.4-0.4-0.4-0.4-0.40.6-0.60.50.00.00.0-0.3
Total locomotion distance, hab. session 20.20.20.7-0.3-0.4-0.4-0.4-0.40.6-0.60.5-0.20.30.2-0.9
Locomotion velocity, hab. session 20.10.20.7-0.1-0.2-0.2-0.2-0.20.4-0.40.3-0.40.50.5-0.8
Novel to familiar place preference ratio1.21.24.5-0.9-0.9-0.8-0.8-0.90.7-0.61.41.0-1.0-1.0-2.1
Novelty place preference1.51.64.5-1.1-1.1-1.1-1.1-1.10.9-0.91.61.1-1.2-1.3-2.1
Time in novel zone, NPP test1.51.54.3-1.1-1.1-1.0-1.0-1.00.8-0.81.61.2-1.3-1.3-2.1
Total zone transitions, NPP test0.91.32.11.21.11.11.11.1-1.01.0-1.2-1.41.51.20.9
Total locomotion distance, NPP test1.42.03.21.41.41.41.41.4-1.21.2-1.5-1.81.71.60.5
Locomotion velocity, NPP test2.02.84.51.71.71.61.61.6-1.51.4-1.8-2.12.02.00.6
Intraocular pressure5.17.111.1-2.9-2.8-2.8-2.8-2.72.6-2.52.43.3-2.8-2.90.5
Delta distance traveled before/after self-admin1.71.82.5-1.4-1.4-1.5-1.4-1.41.2-1.41.41.6-1.5-1.20.1
Delta ambulatory time before/after self-admin0.40.50.9-0.7-0.7-0.7-0.7-0.70.5-0.70.80.9-0.9-0.60.3
Parametrial fat weight8.716.918.9-4.3-4.4-4.3-4.4-4.44.3-4.24.33.6-3.8-3.7-3.6
Pavlov. Cond. lever latency0.81.01.7-0.9-0.9-0.9-0.9-0.90.7-0.61.31.2-1.2-1.3-1.0
Pavlov. Cond. magazine entry latency0.00.00.1-0.1-0.2-0.2-0.2-0.20.2-0.30.1-0.20.10.10.2
Pavlov. Cond. change in total contacts0.00.00.10.10.10.10.10.1-0.20.1-0.3-0.20.1-0.00.0
Pavlov. Cond. index score0.20.20.50.40.30.30.30.3-0.20.1-0.7-0.70.70.70.5
Pavlov. Cond. latency score0.20.20.60.30.20.20.20.2-0.0-0.0-0.7-0.70.70.70.8
Pavlov. Cond. lever contacts0.50.61.00.70.70.70.70.7-0.60.6-1.0-1.00.90.90.5
Pavlov. Cond. magazine entry number0.10.10.3-0.2-0.2-0.1-0.1-0.1-0.00.10.20.6-0.6-0.6-0.2
Pavlov. Cond. intertrial magazine entries1.72.12.71.61.61.61.61.6-1.61.7-1.5-1.11.11.10.9
Pavlov. Cond. lever-magazine prob. diff.0.60.81.50.80.80.80.80.8-0.60.6-1.0-1.21.21.20.5
Pavlov. Cond. response bias1.01.21.71.11.11.11.11.1-1.01.0-1.1-1.31.21.20.3
Pavlov. Cond. lever latency1.01.32.0-1.3-1.2-1.2-1.2-1.11.0-1.1-0.11.2-1.3-1.40.9
Pavlov. Cond. magazine entry latency0.10.10.50.20.10.10.00.00.1-0.10.5-0.60.70.5-0.5
Pavlov. Cond. change in total contacts0.30.41.90.40.30.30.30.2-0.10.20.5-0.70.90.7-1.4
Pavlov. Cond. index score0.60.71.80.80.80.80.70.7-0.60.60.1-1.21.31.0-0.9
Pavlov. Cond. latency score0.60.71.90.80.80.80.70.7-0.60.60.1-1.21.41.0-0.8
Pavlov. Cond. lever contacts0.40.61.40.70.70.70.70.6-0.50.60.5-0.81.00.9-1.2
Pavlov. Cond. magazine entry number0.10.10.60.10.20.20.20.2-0.30.3-0.70.3-0.4-0.20.7
Pavlov. Cond. intertrial magazine entries2.63.44.7-1.9-1.9-1.9-1.9-1.91.8-1.81.82.2-2.0-2.0-0.5
Pavlov. Cond. lever-magazine prob. diff.0.30.41.30.50.50.40.40.4-0.30.30.3-1.01.10.8-1.0
Pavlov. Cond. response bias0.60.91.81.00.90.90.90.8-0.70.70.1-1.11.31.3-0.9
Time in closed arm before self-admin0.20.20.3-0.5-0.5-0.5-0.5-0.50.4-0.40.10.4-0.4-0.5-0.3
Time in closed arm after self-admin0.60.60.9-0.9-0.9-0.9-0.9-0.90.9-0.90.10.6-0.6-0.80.6
Time in open arm before self-admin0.00.00.1-0.2-0.2-0.2-0.2-0.2-0.1-0.10.30.3-0.0-0.3-0.2
Time in open arm after self-admin0.60.71.20.80.80.80.70.7-0.40.5-1.1-1.11.01.00.3
Bone: periosteal estimation0.40.84.20.50.50.40.40.5-0.40.2-1.6-0.80.80.72.1
Bone: periosteal perimeter0.10.10.7-0.0-0.0-0.1-0.1-0.10.0-0.2-0.6-0.20.20.20.8
Bone: post-yield work1.42.02.81.41.41.51.51.5-1.61.7-1.6-1.00.80.91.5
Progressive ratio test 1 active lever presses3.03.25.01.91.91.91.91.9-1.81.8-2.2-1.71.61.61.1
Progressive ratio test 1 breakpoint2.52.64.61.71.71.71.71.7-1.61.6-2.1-1.71.51.50.9
Progressive ratio test 1 inactive lever presses5.76.28.22.72.62.62.62.6-2.42.4-2.7-2.92.72.40.8
Progressive ratio test 2 active lever presses1.41.53.01.21.31.31.31.4-1.71.6-1.4-0.50.50.41.4
Progressive ratio test 2 breakpoint1.51.63.31.31.41.41.41.4-1.81.6-1.4-0.60.60.51.2
Progressive ratio test 2 inactive lever presses3.03.54.32.02.01.91.92.0-2.01.8-2.1-1.91.81.71.0
Incentive Sensitization - Responses1.01.04.50.60.80.80.80.9-1.41.2-0.80.2-0.2-0.32.1
Incentive Sensitization - Breakpoint0.60.63.00.40.50.50.60.7-1.20.9-0.50.4-0.5-0.51.7
Sum of active levers in priming session hrs 5-60.20.21.0-0.0-0.1-0.2-0.2-0.20.2-0.6-0.4-0.50.20.51.0
Progressive ratio0.20.20.30.50.40.40.40.4-0.40.3-0.4-0.60.50.50.6
Food seeking constrained by brief footshock11.514.119.83.84.03.94.04.1-4.44.2-3.8-2.83.02.63.8
Seeking ratio, punishment vs. effort1.11.32.01.11.21.31.31.3-1.41.4-1.3-0.60.90.61.0
Retroperitoneal fat weight25.182.599.8-9.7-9.8-9.9-9.9-9.910.0-9.88.98.0-8.0-8.0-6.1
Reaction time number correct0.20.30.50.60.60.60.50.5-0.40.5-0.6-0.60.70.6-0.6
Reaction time mean minus median0.20.22.20.10.00.10.00.00.00.00.4-0.20.10.2-1.5
Reaction time mean minus median AUC0.10.21.0-0.2-0.2-0.2-0.2-0.20.3-0.20.70.3-0.2-0.1-1.0
Reaction time num false alarms0.81.13.1-1.1-1.2-1.3-1.3-1.21.4-1.80.60.2-0.4-0.20.5
Reaction time num false alarms AUC0.91.23.2-1.1-1.2-1.4-1.3-1.31.4-1.80.70.3-0.5-0.30.3
Reaction time trials correct on left0.20.30.50.60.60.60.50.5-0.40.5-0.6-0.60.70.6-0.6
Reaction time trials on left0.20.30.50.60.60.60.60.5-0.30.4-0.6-0.70.70.6-0.6
Reaction time mean0.50.61.8-0.6-0.5-0.4-0.5-0.50.2-0.01.21.1-0.8-1.4-1.1
Reaction time mean AUC0.40.51.5-0.5-0.4-0.3-0.3-0.30.10.11.11.0-0.8-1.2-1.0
Median of all reaction times0.40.62.3-0.6-0.5-0.4-0.4-0.40.00.11.11.2-0.9-1.5-0.7
Reaction time omissions0.10.10.6-0.2-0.2-0.2-0.2-0.30.5-0.5-0.30.2-0.40.40.8
Reaction time false alarm rate1.21.73.8-1.4-1.5-1.6-1.6-1.51.6-2.01.10.6-0.9-0.60.3
Reaction time premature initiation rate0.20.31.5-0.5-0.5-0.5-0.5-0.50.4-0.41.20.7-0.3-0.5-0.4
Reaction time premature initiations0.10.10.5-0.1-0.1-0.1-0.1-0.10.2-0.10.70.30.2-0.1-0.6
Std. dev. reaction times0.40.52.5-0.5-0.5-0.5-0.5-0.50.6-0.41.10.5-0.3-0.6-1.6
Reaction time trials completed0.20.30.50.60.60.60.60.5-0.30.4-0.6-0.70.70.6-0.6
Reaction time trials AUC0.30.50.80.70.70.70.60.6-0.40.5-0.7-0.80.90.8-0.6
Run reversals in cocaine runway, females0.20.20.60.20.30.40.40.4-0.50.70.30.10.0-0.3-0.8
Run reversals in cocaine runway, males0.60.61.30.80.91.00.90.9-1.01.1-0.5-0.50.50.4-0.4
Latency to leave start box in cocaine runway0.50.50.60.80.80.80.80.7-0.70.7-0.5-0.80.50.8-0.7
Latency to leave start box in cocaine runway, F0.20.20.50.50.50.40.40.4-0.40.3-0.4-0.70.40.70.1
Latency to leave start box in cocaine runway, M1.41.42.01.31.31.41.31.3-1.21.4-1.0-1.11.01.0-0.6
Std. dev. time between licks in bursts0.70.91.3-1.0-1.0-1.1-1.1-1.01.0-1.10.60.9-0.8-0.50.6
Total sessions with >9 infusions5.96.57.92.72.82.82.82.8-2.82.8-2.7-2.12.12.12.1
Short access day 1 total inactive lever presses3.84.26.62.12.12.12.12.0-1.61.8-2.6-2.32.32.31.0
Short access day 10 total inactive lever presses0.40.41.30.30.20.10.10.00.3-0.4-0.5-1.21.11.0-0.9
Short access day 1 total infusions5.96.37.92.62.62.62.62.6-2.32.3-2.8-2.62.62.71.5
Short access day 10 total infusions5.96.58.32.72.72.82.82.7-2.72.7-2.9-2.32.22.21.3
Short access total infusions5.05.77.42.52.52.52.52.5-2.42.5-2.7-2.32.12.11.6
Short access day 1 locomotion7.07.511.03.02.92.92.82.8-2.32.5-2.3-3.33.33.0-0.1
Short access day 10 total locomotion1.11.21.71.21.21.21.21.2-1.21.2-0.8-1.31.30.8-0.3
Short access total locomotion1.71.82.81.51.51.61.51.6-1.41.7-1.1-1.21.20.90.2
One hour access (0.3 mA shock)2.52.97.01.71.71.71.71.7-1.61.7-2.6-1.61.51.51.4
Compulsive drug intake2.22.34.5-1.6-1.7-1.7-1.7-1.72.1-1.90.81.2-1.4-0.80.3
One hour access (shock baseline)4.65.47.82.42.52.52.52.5-2.82.7-2.5-1.91.91.71.3
Social response proportion0.30.31.10.00.10.20.20.2-0.30.50.51.0-1.1-0.4-0.9
Social responses0.10.20.4-0.4-0.4-0.4-0.4-0.40.4-0.40.20.5-0.6-0.4-0.5
Social time0.10.20.7-0.00.10.20.20.2-0.30.5-0.10.5-0.5-0.5-0.8
Soleus weight2.88.211.13.03.03.03.02.9-2.72.7-3.3-3.13.03.10.2
Bone: stiffness0.10.20.6-0.4-0.4-0.5-0.5-0.40.4-0.5-0.50.1-0.1-0.30.8
Tibialis anterior weight1.75.812.32.42.22.12.12.1-1.61.4-2.8-3.53.43.1-0.5
Time to tail flick, vehicle, before self-admin0.91.02.0-1.0-1.0-1.0-1.0-0.90.5-0.71.41.1-1.0-1.3-0.0
Time to tail flick, vehicle, after self-admin4.75.17.5-2.3-2.4-2.3-2.4-2.52.7-2.42.01.8-2.0-1.7-2.2
Time to tail flick, test, before self-admin0.90.91.21.01.01.01.01.0-1.11.0-0.6-0.90.90.81.1
Time to tail flick, test, after self-admin0.30.31.00.50.60.60.60.7-1.01.0-0.30.1-0.2-0.20.1
Delta time to tail flick, vehicle, before/after SA1.41.34.8-0.9-1.0-1.0-1.1-1.21.7-1.40.80.3-0.60.1-2.2
Delta time to tail flick, test, before/after SA0.90.81.60.91.01.01.01.1-1.31.3-0.9-0.50.40.5-0.1
Tibia length1.23.57.2-2.0-1.8-1.8-1.8-1.71.3-1.31.12.6-2.7-2.50.6
Ambulatory time before self-admin0.30.32.80.30.30.40.30.3-0.20.50.0-0.50.40.0-1.7
Ambulatory time after self-admin0.40.40.9-0.6-0.5-0.4-0.5-0.50.2-0.20.60.9-0.9-0.9-0.8
Bone: tissue strength0.90.91.6-0.8-0.8-0.7-0.8-0.80.8-0.61.21.1-1.1-1.1-1.3
Total heroin consumption2.12.53.61.51.41.41.41.4-1.41.2-1.9-1.91.61.81.9
Bone: trabecular number3.35.18.62.32.32.22.32.3-2.32.1-2.9-1.91.82.32.3
Bone: trabecular spacing1.62.03.9-1.4-1.3-1.3-1.3-1.21.0-0.91.81.8-1.7-2.0-0.9
Bone: trabecular thickness0.50.61.10.80.70.70.70.7-0.70.6-1.0-0.90.80.80.2
Bone: trabecular tissue density0.30.41.40.50.50.60.50.5-0.30.6-0.4-1.01.20.5-0.7
Water consumed over 24 hours0.10.10.70.30.30.20.20.2-0.1-0.00.1-0.30.30.8-0.0
Number of responses in last shaping day1.61.73.11.41.51.51.51.5-1.81.6-0.8-0.70.91.10.4