Hub : Genes

Zfp133

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Zfp133 0.14 0.06 1.1e-16 0.16 0.14 0.16 0.02 5.4e-17 9.3e-15 7.0e-17 2.9e-03
2 Brain gene expression Zfp133 0.16 0.08 4.0e-12 0.14 0.12 0.15 0.1 3.0e-13 1.1e-11 9.1e-14 2.5e-09
3 IC gene expression Zfp133 0.07 0.05 9.6e-03 0.04 0.03 0.04 0.04 9.8e-03 1.5e-02 9.7e-03 1.2e-02
4 NAcc gene expression Zfp133 0.07 0.04 1.3e-10 0.06 0.06 0.07 0.04 1.3e-09 4.2e-09 2.0e-10 3.2e-06
5 LHb gene expression Zfp133 0.17 0.13 8.1e-03 0.03 0.02 -0.01 0.03 6.4e-02 1.0e-01 6.1e-01 7.2e-02
6 Adipose gene expression Zfp133 0.16 0.08 5.1e-15 0.07 0.12 0.12 0.12 1.7e-08 3.7e-13 4.5e-13 3.0e-13
7 pVTA gene expression Zfp133 0.07 0.04 4.6e-06 0.06 0.05 0.05 0.05 1.2e-05 1.2e-04 3.5e-05 4.8e-05
8 LHb isoform ratio NM_001024313.1 0.17 0.11 3.6e-03 0.09 0.04 0.02 0.06 3.1e-03 3.2e-02 1.0e-01 1.3e-02
9 LHb isoform ratio XM_063284386.1 0.18 0.11 2.3e-03 0.1 0.05 0.06 0.07 2.0e-03 2.7e-02 1.9e-02 9.7e-03
10 Liver alternative TSS NM_001024313.1 0.04 0.04 2.5e-03 0.01 0.02 0.03 0.01 4.9e-02 6.1e-03 6.3e-04 2.0e-02
11 Liver alternative TSS XM_063284386.1 0.04 0.04 2.8e-03 0.02 0.01 0.03 0.01 4.3e-03 7.7e-03 6.0e-04 2.1e-02
12 BLA gene expression Zfp133 0.05 0.04 9.4e-03 0.03 0.01 0.04 0 7.1e-03 7.6e-02 3.1e-03 3.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.30.62.6-0.4-0.1-0.2-0.30.00.9-0.1-0.30.31.6-1.60.4
Area under the delay curve1.21.95.1-1.4-1.1-0.8-1.10.32.2-0.5-0.10.12.2-2.2-1.4
BMI with tail8.028.139.36.36.16.26.06.2-4.65.85.7-5.7-2.42.24.2
BMI without tail3.820.331.75.35.45.45.35.6-4.04.94.5-4.5-1.71.63.3
Body weight9.340.561.87.97.47.47.07.1-6.16.76.4-6.4-3.63.45.1
Weight adjusted by age0.10.20.5-0.4-0.4-0.4-0.5-0.30.0-0.7-0.70.7-0.00.1-0.3
Bone surface0.20.40.70.70.80.70.80.7-0.50.60.5-0.50.3-0.40.6
Bone volume0.10.10.40.30.40.20.30.3-0.10.1-0.10.10.6-0.60.2
Breakpoint value in progressive ratio session0.20.41.00.60.80.61.00.4-0.90.50.6-0.6-0.40.40.0
Number of licking bursts0.10.41.50.10.20.30.10.50.60.40.4-0.41.2-1.20.5
Context. condit. distance diff. score0.10.10.40.20.30.20.30.0-0.60.00.1-0.1-0.20.30.3
Locomotion velocity, session 11.41.54.8-1.3-1.2-1.4-0.9-1.40.2-1.4-1.11.1-0.80.8-2.2
Locomotion distance, session 13.74.77.5-2.5-2.6-2.5-2.5-2.32.1-2.3-2.12.10.2-0.1-2.7
Locomotion velocity, session 22.02.45.1-1.8-1.9-1.6-1.9-1.32.3-1.2-1.21.20.3-0.3-2.0
Locomotion distance, session 24.66.49.5-2.7-2.8-2.9-2.7-2.91.6-2.9-2.92.90.3-0.2-3.1
Locomotion velocity, session 32.73.14.6-2.1-2.0-2.0-2.0-1.91.8-1.8-1.81.80.7-0.6-1.7
Locomotion distance, session 31.01.12.1-1.3-1.2-1.1-1.2-1.01.4-0.9-1.01.00.7-0.7-0.9
Stereotopy head waving bouts, day 30.10.20.90.2-0.1-0.1-0.0-0.2-0.4-0.2-0.20.2-0.90.9-0.1
Stereotopy head waving duration, day 30.20.20.70.40.30.20.30.1-0.70.10.1-0.1-0.80.90.1
Locomotion velocity, session 71.51.72.7-1.0-1.3-1.3-1.5-1.30.6-1.2-1.31.3-1.61.7-1.2
Locomotion distance, session 70.70.93.8-0.1-0.5-0.5-0.7-0.6-0.1-0.6-0.70.7-1.92.0-0.9
Stereotopy head waving bouts, day 70.10.10.20.30.20.40.20.50.10.50.3-0.3-0.20.20.4
Stereotopy head waving duration, day 70.10.10.2-0.5-0.4-0.3-0.3-0.20.4-0.2-0.40.40.3-0.3-0.0
Locomotion velocity, session 81.11.43.5-1.0-1.1-1.2-1.0-1.3-0.0-1.3-1.11.1-1.01.1-1.9
Locomotion distance, session 82.13.14.8-1.8-1.9-2.0-1.9-2.10.7-2.1-2.02.0-0.30.4-2.2
Degree of sensitization distance1.31.45.91.10.70.60.50.5-1.40.30.3-0.3-2.42.4-0.1
Degree of sensitization stereotypy0.30.30.50.50.60.70.70.7-0.30.70.4-0.40.2-0.20.6
Conditioned locomotion0.40.51.2-0.3-0.2-0.4-0.1-0.6-0.7-0.7-0.70.7-1.11.1-0.7
Cocaine response after cond. corrected1.11.62.4-1.0-1.4-1.4-1.6-1.50.7-1.4-1.51.5-0.40.5-1.4
Cocaine response after cond. not corrected1.82.64.2-1.5-1.9-1.9-2.1-1.81.0-1.8-1.91.90.00.1-1.6
Cocaine response before conditioning0.20.20.6-0.6-0.5-0.5-0.5-0.20.3-0.4-0.10.10.7-0.70.1
Saline control response1.01.45.91.10.80.60.70.2-2.4-0.1-0.50.5-1.91.9-0.5
Bone: connectivity density0.40.62.8-0.7-0.4-0.5-0.4-0.30.8-0.3-0.40.41.6-1.70.3
Bone: cortical apparent density0.30.51.5-0.7-0.4-0.4-0.4-0.20.9-0.2-0.10.11.2-1.20.8
Bone: cortical area0.20.31.00.50.40.60.41.00.20.60.6-0.60.6-0.70.5
Bone: cortical porosity0.30.41.00.40.50.60.70.7-0.10.50.4-0.40.9-1.0-0.0
Bone: cortical porosity0.50.51.00.70.80.80.91.0-0.50.70.6-0.60.8-0.90.1
Bone: cortical thickness0.71.24.8-0.00.30.50.41.10.80.70.8-0.82.1-2.21.0
Bone: cortical thickness0.80.92.8-1.2-1.1-0.8-1.2-0.21.7-0.6-0.60.61.0-1.0-0.7
Bone: cortical tissue density0.20.41.1-0.7-0.4-0.4-0.4-0.30.8-0.2-0.10.11.0-1.00.8
Condit. Reinf. active minus inactive responses0.20.21.2-0.00.0-0.0-0.0-0.10.2-0.1-0.10.11.1-1.10.4
Condit. Reinf. active-inactive response ratio0.20.31.4-0.1-0.1-0.2-0.2-0.20.3-0.2-0.10.11.2-1.20.2
Condit. Reinf. active responses0.10.20.6-0.2-0.2-0.2-0.3-0.30.5-0.2-0.40.40.8-0.80.1
Condit. Reinf. inactive responses0.20.31.50.1-0.1-0.0-0.1-0.1-0.1-0.0-0.30.3-1.21.2-0.2
Incentive salience index mean0.60.82.5-0.8-0.6-0.5-0.7-0.31.5-0.2-0.40.41.6-1.6-0.0
Condit. Reinf. lever presses0.60.94.9-0.7-0.6-0.2-0.60.32.20.4-0.10.11.5-1.50.2
Condit. Reinf. active minus inactive responses1.21.84.11.51.41.21.50.9-2.00.90.8-0.8-1.81.70.8
Condit. Reinf. active-inactive response ratio0.71.22.21.21.31.21.40.9-1.50.90.9-0.9-0.90.90.7
Condit. Reinf. active responses0.81.21.71.11.21.11.31.1-1.21.11.0-1.0-0.80.81.2
Condit. Reinf. inactive responses0.20.20.80.20.20.40.40.60.40.70.5-0.50.4-0.40.9
Condit. Reinf. lever presses2.74.06.62.22.52.32.61.9-2.41.91.8-1.8-1.00.91.9
Condit. Reinf. lever reinforcers received1.01.52.41.31.41.21.61.1-1.41.21.1-1.1-0.90.91.3
Conditioned reinforcement - actives0.52.03.7-0.5-1.0-1.2-1.0-1.6-0.9-1.7-1.51.5-1.81.9-1.6
Conditioned reinforcement - inactives0.82.34.8-0.7-1.0-1.5-1.1-2.2-1.3-2.0-1.31.3-1.81.9-1.3
Conditioned locomotion0.30.40.9-1.0-0.7-0.8-0.5-0.70.5-0.8-0.20.20.8-0.8-0.4
Patch foraging indifference point 0 sec0.51.33.8-0.0-0.4-0.7-0.4-1.4-1.3-1.1-1.01.0-1.92.0-0.7
Patch foraging indifference point AUC0.51.33.3-1.3-1.1-1.0-0.9-0.71.6-0.7-0.60.61.8-1.8-0.4
Delay disc. indifference point, 0s delay0.70.71.50.10.40.70.51.20.90.91.1-1.11.1-1.10.0
Delay disc. indifference point, 16s delay1.52.14.4-1.6-1.4-1.2-1.4-0.62.1-1.0-1.01.02.0-2.0-1.5
Delay disc. indifference point, 2s delay0.70.72.60.20.50.70.51.60.90.90.9-0.91.0-1.00.1
Delay disc. indifference point, 24s delay2.84.58.0-2.5-2.5-2.2-2.6-1.32.8-1.9-1.61.61.7-1.7-2.5
Delay disc. indifference point, 4s delay0.60.62.20.00.10.50.01.51.20.70.7-0.71.0-1.0-0.6
Delay disc. indifference point, 8s delay1.11.94.0-1.7-1.3-1.2-1.1-0.41.7-1.1-0.60.62.0-2.0-1.5
Indifference point function ln k0.30.84.00.1-0.0-0.2-0.1-0.3-1.1-0.5-0.10.1-2.02.0-0.3
Indifference point function log k0.30.84.00.1-0.0-0.2-0.1-0.3-1.1-0.5-0.10.1-2.02.0-0.3
Patch foraging total patch changes 0 sec0.41.22.5-0.3-0.6-0.9-0.6-1.6-1.0-1.3-1.11.1-1.51.5-0.9
Patch foraging total patch changes 12 sec0.10.10.30.30.10.30.10.4-0.20.20.3-0.3-0.60.6-0.3
Patch foraging total patch changes 18 sec0.51.33.0-1.0-1.2-1.3-1.2-1.70.1-1.5-1.41.40.00.1-0.6
Patch foraging total patch changes 24 sec0.10.20.4-0.2-0.3-0.3-0.3-0.50.2-0.3-0.60.60.6-0.5-0.7
Patch foraging total patch changes 6 sec0.10.20.9-0.3-0.4-0.5-0.5-1.0-0.0-0.6-0.60.6-0.30.3-0.3
Patch foraging time to switch 0 sec0.62.33.61.91.61.91.41.9-0.91.91.6-1.6-0.70.61.5
Patch foraging water rate 0 sec0.82.84.4-2.1-1.8-2.0-1.7-2.01.5-1.9-1.61.61.1-1.1-1.4
Patch foraging water rate 12 sec1.24.87.5-2.5-2.4-2.2-2.4-1.82.7-1.8-1.61.62.6-2.6-1.5
Patch foraging water rate 18 sec5.211.716.8-3.7-3.9-3.8-4.1-3.62.9-3.7-3.83.81.0-0.9-3.9
Patch foraging water rate 24 sec3.14.46.2-2.3-2.4-2.4-2.4-2.41.2-2.5-2.32.30.3-0.2-2.4
Patch foraging water rate 6 sec3.95.77.6-2.7-2.7-2.7-2.6-2.52.1-2.5-2.52.51.4-1.4-2.3
Seeking ratio, delayed vs. immediate footshock0.30.51.40.90.60.40.60.1-1.20.40.2-0.2-1.11.10.2
Distance traveled before self-admin0.20.41.00.50.40.60.21.00.60.80.8-0.80.1-0.10.5
Distance traveled after self-admin0.50.83.3-1.0-0.4-0.5-0.2-0.11.1-0.3-0.20.21.8-1.80.3
Extensor digitorum longus weight0.10.30.90.90.50.50.50.3-0.70.1-0.10.1-0.70.7-0.0
Bone: elastic displacement0.30.40.90.50.60.80.70.7-0.10.90.8-0.8-0.60.60.3
Bone: elastic work2.33.15.41.81.92.12.02.3-0.82.22.1-2.1-0.50.51.3
Bone: endosteal estimation1.84.39.82.62.01.91.81.6-2.61.31.3-1.3-3.13.10.3
Bone: endosteal perimeter0.30.72.71.10.80.50.60.3-1.60.1-0.10.1-1.31.3-0.4
Epididymis fat weight5.427.537.56.16.05.85.85.5-5.55.25.2-5.2-3.93.74.3
Delta time in closed arm before/after self-admin0.20.20.4-0.5-0.4-0.6-0.5-0.70.3-0.6-0.20.20.2-0.20.2
Delta time in open arm before/after self-admin1.92.33.41.81.81.81.81.4-1.41.61.5-1.5-0.50.41.8
Diff in mean of infusions in LGA sessions0.30.61.90.20.10.50.00.61.40.90.9-0.90.8-0.90.6
Delay discount exponential model param1.52.05.31.61.21.01.3-0.2-2.30.70.3-0.3-2.22.11.5
Extinction: sum of active levers before priming0.20.31.0-0.4-0.5-0.6-0.4-1.0-0.0-0.6-0.50.5-0.40.4-0.6
Active lever presses in extinction session 61.91.93.01.51.51.21.61.2-1.71.01.3-1.3-1.51.50.8
Bone: final force0.30.51.40.90.70.80.61.2-0.30.70.8-0.8-0.10.00.2
Bone: final moment0.20.41.10.80.60.70.51.1-0.10.70.7-0.70.0-0.00.2
Food consumed during 24 hour testing period0.10.10.40.50.20.4-0.10.60.30.4-0.20.2-0.20.2-0.3
Glucose1.11.84.51.41.20.91.20.6-2.10.60.9-0.9-2.12.10.6
Heart weight1.22.03.61.51.41.41.51.7-1.90.91.1-1.1-1.61.60.3
Delay discount hyperbolic model param1.01.33.91.20.90.60.9-0.5-2.00.3-0.00.0-1.91.91.2
Intermittent access intake day 1-15 change0.31.73.31.51.21.01.10.8-1.80.91.3-1.3-1.71.60.8
Intermittent access intake escalation0.21.32.81.30.90.80.80.6-1.50.71.2-1.2-1.71.60.7
Intermittent access intake escalation 21.01.72.61.51.31.11.10.9-1.51.01.6-1.6-1.21.21.5
Intermitt. access day 1 inactive lever presses0.10.81.6-0.6-0.9-1.1-1.0-1.2-0.1-1.3-1.11.1-0.50.6-0.8
Intermitt. access day 15 inactive lever presses0.42.38.81.10.50.00.4-1.0-2.6-0.5-0.10.1-3.03.00.9
Intermitt. access escalation Index0.10.41.10.50.90.61.00.8-0.50.70.4-0.40.5-0.50.6
Intermittent access day 1 total infusions0.00.10.20.1-0.10.10.10.2-0.3-0.10.2-0.2-0.50.4-0.4
Intermittent access day 15 total infusions0.61.64.21.30.80.80.80.8-1.60.51.3-1.3-2.12.00.3
Intermittent access terminal intake (last 3 days)1.12.04.21.61.01.11.01.0-1.70.91.5-1.5-2.02.00.5
Intermittent access total infusions0.81.02.31.10.80.81.00.5-1.50.51.0-1.0-1.41.30.5
Intermittent access day 1 locomotion0.20.41.0-0.9-0.7-0.5-0.50.11.0-0.4-0.10.10.9-0.9-0.7
Intermittent access day 15 total locomotion0.20.71.30.60.80.80.90.5-1.10.51.2-1.2-0.60.50.9
Intermittent access total locomotion0.00.10.2-0.3-0.2-0.00.00.10.1-0.10.4-0.40.2-0.2-0.2
Intermittent access standard deviation0.00.31.10.1-0.0-0.2-0.0-0.5-0.6-0.20.3-0.3-1.01.00.2
Left kidney weight0.65.18.72.92.62.52.62.4-2.62.22.1-2.1-1.61.51.4
Right kidney weight0.21.53.11.81.51.21.41.2-1.61.10.8-0.8-1.00.90.6
Cocaine induced anxiety0.10.40.8-0.6-0.5-0.8-0.3-0.6-0.2-0.8-0.80.8-0.20.2-0.9
Post-drug Anxiety0.40.50.70.80.70.60.70.6-0.80.60.7-0.7-0.70.70.4
Baseline Anxiety2.03.35.81.91.92.11.71.9-1.02.12.4-2.4-0.40.32.1
Tail length0.31.42.21.51.51.51.31.4-1.31.20.8-0.8-0.80.70.7
Length with tail1.67.212.73.63.23.12.82.7-3.22.52.1-2.1-2.32.22.1
Length without tail1.05.39.23.02.62.42.42.1-2.62.02.2-2.2-1.51.42.4
Times rat made contact with spout3.03.44.52.12.12.02.11.9-1.91.81.8-1.8-1.61.51.6
Lifetime Intake0.60.71.80.90.80.70.90.3-1.30.40.8-0.8-1.11.10.2
Liver weight, left1.42.54.22.11.81.71.61.5-2.11.31.0-1.0-1.71.70.7
Liver weight, right1.72.94.52.11.91.81.71.7-2.01.51.3-1.3-1.91.91.0
Locomotor activity0.20.30.90.40.40.40.50.4-0.60.30.3-0.3-0.90.90.3
Locomotor testing distance0.00.10.1-0.3-0.3-0.2-0.1-0.20.2-0.3-0.10.10.3-0.3-0.1
Locomotor testing rearing0.10.31.00.20.50.50.70.3-0.50.20.4-0.41.0-1.00.4
Locomotion in novel chamber1.31.73.5-1.5-1.1-1.5-0.9-1.90.1-1.7-1.61.60.7-0.6-1.1
Locomotion in novel chamber post-restriction1.03.04.2-1.7-1.7-1.7-1.4-1.91.1-1.9-2.02.01.8-1.7-1.5
Fecal boli incidents, locomotor time 10.72.04.5-1.0-1.3-1.3-1.4-1.20.1-1.6-2.02.0-0.40.5-2.1
Change in fecal boli incidents, locomotor task0.00.00.3-0.20.0-0.10.1-0.5-0.1-0.10.2-0.2-0.10.10.2
Time >=10cm from walls, locomotor time 10.20.30.5-0.7-0.5-0.7-0.6-0.60.4-0.7-0.50.50.4-0.4-0.0
Bouts of movement, locomotor time 11.62.14.9-1.2-1.7-1.5-1.9-1.21.1-1.4-1.71.70.2-0.1-2.2
Total resting periods, locomotor time 12.52.95.7-1.4-1.9-1.8-2.2-1.61.2-1.7-2.02.0-0.10.2-2.4
Rest time, locomotor task time 10.60.91.6-0.4-0.9-0.8-1.2-1.10.1-1.0-1.21.2-0.80.9-1.3
Distance moved, locomotor task time 10.30.93.7-1.1-0.9-0.6-0.70.21.9-0.2-0.20.21.5-1.50.2
Vertical activity count, locomotor time 10.10.61.60.50.70.80.71.20.30.90.6-0.60.9-1.00.7
Time >=10cm from walls, locomotor time 20.41.31.81.21.21.21.31.1-1.31.01.3-1.3-0.80.80.8
Bouts of movement, locomotor time 20.00.10.40.20.20.20.40.7-0.10.30.4-0.40.1-0.1-0.0
Total resting periods, locomotor time 20.00.10.40.30.30.30.50.7-0.30.30.4-0.4-0.10.10.1
Rest time, locomotor task time 20.20.31.1-0.0-0.3-0.4-0.5-0.3-0.1-0.4-0.30.3-1.11.1-0.7
Distance moved, locomotor task time 20.60.72.0-1.0-0.9-0.6-0.8-0.41.4-0.5-0.40.41.3-1.30.1
Vertical activity count, locomotor time 20.20.52.7-0.20.10.20.20.40.60.30.2-0.21.6-1.60.4
Light reinforcement 10.10.31.10.1-0.2-0.3-0.3-0.4-0.5-0.6-0.70.7-0.70.7-1.0
Light reinforcement 20.40.92.0-0.1-0.1-0.60.0-0.9-1.4-1.0-1.31.3-1.01.0-1.2
Bone: marrow area1.74.39.92.62.01.91.81.5-2.61.31.3-1.3-3.13.10.2
Bone: maximum diameter0.51.02.51.61.21.10.91.0-1.30.80.6-0.6-0.90.80.4
Bone: maximum force0.20.31.00.90.60.70.51.0-0.20.60.6-0.60.1-0.10.3
Bone: maximum moment0.20.30.90.80.50.70.41.0-0.00.60.5-0.50.2-0.20.3
Mean time between licks in bursts0.10.83.3-0.7-0.5-0.6-0.4-0.60.5-0.6-0.70.71.8-1.8-0.8
Mean num. licks in bursts0.51.44.91.10.90.80.90.6-1.50.70.6-0.6-2.22.20.2
Cd content in liver0.10.10.50.10.10.2-0.30.20.70.20.2-0.20.2-0.10.1
Co content in liver0.60.71.5-0.7-0.8-0.8-0.8-0.80.3-0.9-0.60.6-1.11.2-1.0
Cu content in liver0.50.61.2-0.6-1.0-0.8-1.1-0.60.6-0.7-0.50.5-0.80.9-1.0
Fe content in liver1.21.42.41.31.21.31.21.4-0.81.31.5-1.5-0.30.31.2
K content in liver1.61.53.5-1.9-1.4-1.0-1.1-0.51.9-0.6-0.40.41.6-1.6-1.0
Mg content in liver0.00.10.3-0.20.00.00.20.0-0.00.20.1-0.10.5-0.5-0.0
Mn content in liver1.41.62.9-1.2-0.9-1.3-0.6-1.5-0.5-1.5-1.61.6-0.80.9-1.7
Na content in liver0.50.51.2-0.10.40.40.70.70.10.71.1-1.10.8-0.81.0
Rb content in liver0.20.20.50.60.30.50.00.60.20.50.7-0.70.1-0.10.2
Se content in liver0.40.41.00.30.30.60.20.90.30.90.7-0.7-1.01.0-0.3
Sr content in liver0.70.61.1-0.7-0.8-0.9-0.8-0.90.3-1.0-1.01.0-0.20.2-1.0
Zn content in liver0.30.31.0-0.7-0.7-0.4-0.7-0.11.0-0.2-0.40.40.3-0.2-1.0
Bone: minimum diameter0.40.81.31.11.01.01.01.0-0.90.80.8-0.8-0.80.80.5
Time in familiar zone, hab. session 10.40.50.80.40.30.60.20.60.90.90.9-0.90.6-0.70.8
Time in novel zone, hab. session 10.30.32.20.20.40.10.50.0-1.5-0.3-0.20.2-0.50.6-0.2
Total zone transitions, hab. session 10.91.21.9-1.3-1.3-1.2-1.4-1.21.2-1.1-1.11.1-0.10.1-1.0
Total locomotion distance, hab. session 11.52.13.3-1.6-1.8-1.7-1.8-1.61.4-1.6-1.61.60.1-0.1-1.4
Locomotion velocity, hab. session 12.02.84.0-1.9-2.0-1.9-2.0-1.81.8-1.7-1.81.80.4-0.4-1.6
Time in familiar zone, hab. session 20.10.10.4-0.3-0.3-0.4-0.1-0.6-0.4-0.5-0.50.5-0.00.1-0.2
Time in novel zone, hab. session 20.60.60.80.90.90.90.70.9-0.70.80.8-0.8-0.70.70.4
Total zone transitions, hab. session 20.30.40.7-0.2-0.2-0.3-0.2-0.4-0.5-0.5-0.80.8-0.80.9-0.9
Total locomotion distance, hab. session 21.01.32.7-0.8-0.8-1.1-0.7-1.4-0.7-1.5-1.61.6-0.50.6-1.5
Locomotion velocity, hab. session 21.52.03.7-1.3-1.3-1.5-1.1-1.7-0.1-1.8-1.91.9-0.20.3-1.8
Novel to familiar place preference ratio0.10.10.30.40.40.40.20.1-0.20.30.3-0.30.4-0.40.6
Novelty place preference0.20.20.60.40.40.50.30.2-0.10.40.4-0.40.8-0.80.7
Time in novel zone, NPP test0.40.50.80.80.80.80.70.5-0.50.70.7-0.70.5-0.60.9
Total zone transitions, NPP test0.60.91.3-1.1-1.1-1.1-1.1-1.00.8-1.0-1.01.0-0.20.3-1.1
Total locomotion distance, NPP test1.52.23.7-1.4-1.5-1.6-1.5-1.70.4-1.8-1.91.9-0.30.3-1.7
Locomotion velocity, NPP test2.02.94.6-1.8-1.8-1.9-1.8-1.90.8-2.0-2.22.2-0.00.1-1.9
Intraocular pressure1.42.34.9-1.0-1.4-1.3-1.6-1.60.4-1.4-2.12.1-0.80.9-2.2
Delta distance traveled before/after self-admin1.11.25.0-1.3-0.6-0.7-0.1-0.80.6-0.7-0.60.62.2-2.2-0.0
Delta ambulatory time before/after self-admin0.61.04.1-1.2-0.5-0.6-0.1-0.70.3-0.7-0.60.62.0-2.00.0
Parametrial fat weight16.639.259.07.77.47.27.36.8-6.26.76.2-6.2-3.43.24.6
Pavlov. Cond. lever latency2.02.59.41.71.40.91.40.4-3.10.40.5-0.5-2.42.40.5
Pavlov. Cond. magazine entry latency0.40.61.30.00.40.50.50.70.80.80.8-0.81.0-1.01.2
Pavlov. Cond. change in total contacts2.42.68.9-1.6-1.3-0.8-1.3-0.33.0-0.2-0.30.32.8-2.70.0
Pavlov. Cond. index score1.31.66.1-1.1-0.7-0.3-0.60.22.50.30.2-0.22.3-2.30.6
Pavlov. Cond. latency score1.72.27.9-1.6-1.1-0.7-1.0-0.22.8-0.2-0.20.22.6-2.60.2
Pavlov. Cond. lever contacts1.01.26.0-1.1-0.9-0.4-0.90.12.50.10.1-0.11.6-1.6-0.1
Pavlov. Cond. magazine entry number0.60.71.70.1-0.2-0.4-0.2-0.7-1.2-0.8-0.70.7-1.31.3-1.1
Pavlov. Cond. intertrial magazine entries1.51.73.0-0.4-0.7-1.1-0.6-1.7-1.4-1.6-1.51.5-1.51.6-1.2
Pavlov. Cond. lever-magazine prob. diff.1.41.86.4-1.0-0.5-0.1-0.50.42.50.50.4-0.42.4-2.40.9
Pavlov. Cond. response bias0.70.93.0-0.2-0.00.4-0.10.81.70.80.8-0.81.4-1.50.9
Pavlov. Cond. lever latency3.85.37.3-2.7-2.6-2.7-2.5-2.62.0-2.5-2.12.11.6-1.5-2.2
Pavlov. Cond. magazine entry latency1.92.76.72.11.91.61.71.1-2.61.11.0-1.0-1.91.90.8
Pavlov. Cond. change in total contacts2.86.89.23.03.02.92.92.8-2.42.82.6-2.6-1.81.72.4
Pavlov. Cond. index score3.96.19.23.02.92.82.82.5-2.72.42.2-2.2-1.71.72.2
Pavlov. Cond. latency score3.04.87.02.72.62.52.52.3-2.32.22.0-2.0-1.41.42.1
Pavlov. Cond. lever contacts3.95.78.12.82.82.82.72.6-2.32.52.2-2.2-1.41.42.4
Pavlov. Cond. magazine entry number3.24.16.5-2.5-2.3-2.1-2.1-1.72.6-1.7-1.51.52.2-2.2-1.6
Pavlov. Cond. intertrial magazine entries0.91.94.5-1.7-1.4-1.2-1.2-0.91.8-0.9-0.80.82.1-2.1-0.6
Pavlov. Cond. lever-magazine prob. diff.4.26.59.63.13.02.92.92.7-2.62.62.4-2.4-1.61.52.4
Pavlov. Cond. response bias4.66.49.53.12.92.82.72.4-3.02.32.0-2.0-2.32.32.1
Time in closed arm before self-admin0.20.31.20.3-0.2-0.2-0.40.1-0.2-0.1-0.40.4-1.11.10.1
Time in closed arm after self-admin0.60.71.1-0.5-0.8-1.0-1.0-0.90.1-1.0-0.90.9-1.01.00.1
Time in open arm before self-admin0.20.31.1-0.30.10.20.40.10.10.10.3-0.31.0-1.1-0.7
Time in open arm after self-admin1.41.63.01.01.41.51.71.3-0.61.51.5-1.50.5-0.61.1
Bone: periosteal estimation0.92.13.81.91.61.51.41.5-1.71.11.1-1.1-1.71.70.3
Bone: periosteal perimeter0.20.31.10.90.80.60.70.5-1.10.20.0-0.0-0.20.1-0.0
Bone: post-yield work0.00.10.20.30.1-0.1-0.1-0.3-0.3-0.3-0.20.2-0.40.50.0
Progressive ratio test 1 active lever presses0.30.51.00.80.60.70.60.5-0.90.50.7-0.7-1.01.0-0.1
Progressive ratio test 1 breakpoint0.30.61.00.90.60.70.70.6-0.90.60.8-0.8-1.01.0-0.0
Progressive ratio test 1 inactive lever presses0.30.83.10.50.1-0.00.1-0.7-1.5-0.5-0.10.1-1.71.8-0.5
Progressive ratio test 2 active lever presses0.40.51.40.70.50.50.50.2-0.90.30.7-0.7-1.21.2-0.1
Progressive ratio test 2 breakpoint0.50.61.60.80.60.50.60.2-1.10.30.7-0.7-1.31.3-0.1
Progressive ratio test 2 inactive lever presses0.62.07.31.31.20.81.30.0-2.70.20.7-0.7-2.22.20.1
Incentive Sensitization - Responses0.10.21.20.30.40.10.5-0.4-1.1-0.20.1-0.1-0.60.6-0.3
Incentive Sensitization - Breakpoint0.10.31.70.50.60.30.7-0.3-1.3-0.10.2-0.2-0.80.8-0.1
Sum of active levers in priming session hrs 5-60.60.51.2-0.4-0.8-0.8-0.7-0.90.1-0.7-0.70.7-0.60.6-1.1
Progressive ratio0.72.14.7-1.0-1.3-1.3-1.3-2.2-0.1-1.6-2.02.0-0.10.2-1.8
Food seeking constrained by brief footshock1.31.72.8-1.5-1.5-1.3-1.1-1.21.7-1.0-1.01.01.3-1.3-1.3
Seeking ratio, punishment vs. effort0.71.53.10.71.01.11.11.70.41.51.8-1.80.4-0.51.5
Retroperitoneal fat weight17.277.0112.210.610.110.19.610.0-7.79.59.0-9.0-5.24.97.2
Reaction time number correct0.62.03.9-1.4-1.3-1.6-1.2-1.60.2-1.9-2.02.00.5-0.4-1.4
Reaction time mean minus median0.42.44.32.11.91.91.81.4-1.71.71.3-1.3-0.90.80.9
Reaction time mean minus median AUC0.32.03.51.91.91.81.81.3-1.71.51.1-1.1-0.30.20.7
Reaction time num false alarms1.72.94.4-2.0-2.1-2.1-2.0-1.61.4-2.1-1.71.7-0.30.3-1.9
Reaction time num false alarms AUC1.02.43.7-1.9-1.9-1.9-1.9-1.41.3-1.9-1.61.6-0.10.1-1.5
Reaction time trials correct on left0.62.03.9-1.4-1.3-1.6-1.2-1.60.2-1.9-2.02.00.5-0.4-1.4
Reaction time trials on left0.61.93.9-1.4-1.2-1.6-1.1-1.60.1-1.9-2.02.00.6-0.5-1.3
Reaction time mean2.04.37.62.82.52.52.32.2-2.12.31.7-1.7-1.61.51.1
Reaction time mean AUC1.43.35.82.42.22.22.12.0-1.82.11.5-1.5-1.31.30.8
Median of all reaction times2.33.66.22.52.22.32.02.1-1.82.11.6-1.6-1.61.51.0
Reaction time omissions0.40.72.01.31.21.11.20.6-1.40.80.1-0.10.1-0.10.1
Reaction time false alarm rate0.50.71.2-1.0-1.1-0.9-1.1-0.61.0-0.9-0.60.6-0.40.4-0.9
Reaction time premature initiation rate0.20.41.6-0.1-0.3-0.3-0.4-0.2-0.1-0.4-0.20.2-1.21.3-0.6
Reaction time premature initiations0.41.32.1-0.9-1.1-1.2-1.1-1.10.0-1.4-1.21.2-1.11.2-1.4
Std. dev. reaction times0.93.05.62.42.12.22.01.8-1.72.01.5-1.5-0.90.81.0
Reaction time trials completed0.61.93.9-1.4-1.2-1.6-1.1-1.60.1-1.9-2.02.00.6-0.5-1.3
Reaction time trials AUC0.62.04.1-1.3-1.2-1.6-1.2-1.7-0.1-2.0-2.02.00.3-0.2-1.4
Run reversals in cocaine runway, females2.12.34.41.31.91.82.11.8-1.31.81.7-1.70.0-0.11.2
Run reversals in cocaine runway, males1.71.94.01.41.31.61.32.0-0.11.81.7-1.70.1-0.21.1
Latency to leave start box in cocaine runway0.40.61.3-0.8-0.5-0.9-0.3-1.1-0.6-1.1-0.90.9-0.50.5-0.6
Latency to leave start box in cocaine runway, F0.30.31.30.20.1-0.00.1-0.3-1.1-0.4-0.20.2-1.11.1-0.3
Latency to leave start box in cocaine runway, M1.21.22.6-1.4-0.9-1.5-0.6-1.6-0.0-1.4-1.41.40.2-0.2-0.5
Std. dev. time between licks in bursts0.61.22.7-1.1-1.0-0.9-0.9-0.81.1-0.8-0.90.91.6-1.6-1.3
Total sessions with >9 infusions0.60.71.50.90.90.91.00.4-1.20.60.8-0.8-1.01.0-0.1
Short access day 1 total inactive lever presses0.51.12.1-0.2-0.6-0.8-0.5-1.2-1.3-1.3-0.90.9-1.41.5-0.9
Short access day 10 total inactive lever presses0.10.93.50.30.1-0.40.0-1.0-1.9-1.0-0.70.7-1.41.50.3
Short access day 1 total infusions0.30.71.8-0.7-0.7-0.7-0.6-1.1-0.1-1.0-0.90.9-0.40.4-1.4
Short access day 10 total infusions0.20.31.00.60.50.30.50.1-1.00.10.5-0.5-0.60.60.2
Short access total infusions0.30.51.30.80.70.70.80.2-1.10.40.7-0.7-0.70.7-0.0
Short access day 1 locomotion0.10.20.70.20.50.30.70.2-0.90.20.5-0.5-0.50.50.0
Short access day 10 total locomotion0.10.40.7-0.7-0.7-0.7-0.8-0.60.6-0.8-0.60.60.4-0.4-0.3
Short access total locomotion0.10.20.7-0.6-0.3-0.2-0.10.00.5-0.3-0.00.00.9-0.8-0.7
One hour access (0.3 mA shock)0.20.31.10.1-0.0-0.20.1-1.1-0.8-0.30.1-0.1-0.80.80.1
Compulsive drug intake1.31.94.3-1.4-1.5-1.4-1.7-2.11.7-1.1-1.41.41.0-1.0-0.3
One hour access (shock baseline)0.51.22.01.01.00.91.10.8-1.40.71.4-1.4-1.11.01.0
Social response proportion3.54.47.22.12.52.32.72.2-2.12.32.0-2.0-1.41.41.7
Social responses0.20.31.10.50.50.60.41.1-0.40.50.3-0.3-0.60.6-0.0
Social time0.71.22.90.91.31.31.41.7-0.81.10.9-0.90.2-0.30.9
Soleus weight0.00.00.10.30.20.10.00.1-0.1-0.2-0.10.1-0.10.10.0
Bone: stiffness0.00.10.20.50.20.20.10.5-0.3-0.0-0.00.00.4-0.4-0.2
Tibialis anterior weight0.51.73.51.91.71.71.51.4-1.01.41.1-1.10.1-0.21.3
Time to tail flick, vehicle, before self-admin2.12.68.61.51.21.01.20.5-2.30.70.6-0.6-2.92.90.7
Time to tail flick, vehicle, after self-admin0.30.51.90.1-0.6-0.4-1.10.10.7-0.3-0.30.3-1.41.4-0.3
Time to tail flick, test, before self-admin0.20.20.60.0-0.5-0.3-0.6-0.40.4-0.2-0.30.3-0.70.7-0.4
Time to tail flick, test, after self-admin1.41.55.1-0.0-0.5-0.7-1.0-1.0-1.0-1.2-1.21.2-2.22.30.4
Delta time to tail flick, vehicle, before/after SA1.01.02.7-0.9-1.2-1.0-1.6-0.61.5-0.9-0.90.90.4-0.4-0.9
Delta time to tail flick, test, before/after SA0.20.30.6-0.1-0.1-0.3-0.3-0.4-0.8-0.6-0.70.7-0.70.80.2
Tibia length1.84.98.02.82.42.62.32.7-1.72.52.1-2.1-1.91.81.0
Ambulatory time before self-admin0.20.61.40.80.70.90.51.20.31.01.1-1.1-0.10.10.7
Ambulatory time after self-admin0.60.94.4-0.9-0.2-0.3-0.10.11.1-0.1-0.00.02.1-2.10.5
Bone: tissue strength0.70.71.10.91.01.11.01.0-0.31.00.9-0.90.1-0.20.8
Total heroin consumption0.50.61.90.20.2-0.20.3-0.7-1.3-0.5-0.30.3-1.31.4-0.8
Bone: trabecular number0.30.62.1-0.7-0.4-0.4-0.4-0.20.9-0.2-0.40.41.4-1.50.3
Bone: trabecular spacing1.62.43.31.81.41.61.31.5-1.31.51.7-1.7-1.81.71.0
Bone: trabecular thickness0.30.41.1-0.6-0.5-0.4-0.5-0.11.0-0.2-0.30.31.0-1.0-0.3
Bone: trabecular tissue density0.50.91.90.50.61.00.71.10.21.11.4-1.41.0-1.00.8
Water consumed over 24 hours0.20.52.20.40.20.00.0-0.1-0.9-0.2-0.30.3-1.51.5-0.3
Number of responses in last shaping day0.81.02.0-0.5-0.8-0.8-1.0-1.4-0.2-1.1-1.01.0-1.31.4-0.7