Best TWAS P = 7.98e-11 · Best GWAS P= 7.74e-11 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Alg8 | alternative TSS | NM_001034127.1 | 0.04 | 1 | 0.02 | 3.9e-03 | 5.63 | 1.75e-08 | 0.04 | FALSE |
| Adipose | Alg8 | alternative TSS | XM_039105983.2 | 0.2 | 1 | 0.12 | 1.8e-13 | -5.49 | 4.08e-08 | 0.26 | FALSE |
| Adipose | Alg8 | alternative TSS | XM_039105971.2 | 0.06 | 1 | 0.04 | 4.8e-05 | -5.49 | 4.08e-08 | 0.08 | FALSE |
| Adipose | Clns1a | alternative TSS | NM_031719.2 | 0.07 | 146 | 0.02 | 3.6e-03 | -5.69 | 1.30e-08 | 0.31 | FALSE |
| Adipose | Clns1a | alternative TSS | XM_006229792.3 | 0.08 | 89 | 0.02 | 1.9e-03 | 5.79 | 6.84e-09 | 0.29 | FALSE |
| Adipose | Kctd21 | alternative TSS | XM_006229781.5 | 0.08 | 1 | 0.05 | 1.4e-06 | -5.49 | 4.08e-08 | 0.21 | FALSE |
| Adipose | Kctd21 | alternative TSS | XM_039087670.2 | 0.09 | 1 | 0.06 | 9.2e-07 | 5.49 | 4.08e-08 | 0.22 | FALSE |
| Adipose | Kctd21 | alternative TSS | XM_039087670.2 | 0.04 | 1856 | 0.02 | 5.1e-03 | 5.74 | 9.62e-09 | 0.45 | FALSE |
| Adipose | Alg8 | gene expression | Alg8 | 0.35 | 39 | 0.02 | 2.1e-03 | -6.13 | 8.75e-10 | 0.74 | FALSE |
| Adipose | Aqp11 | gene expression | Aqp11 | 0.49 | 1793 | 0.33 | 1.2e-37 | 5.43 | 5.52e-08 | 0.22 | FALSE |
| Adipose | Ints4 | gene expression | Ints4 | 0.03 | 1 | 0.01 | 7.2e-03 | 6.32 | 2.60e-10 | 0.09 | FALSE |
| Adipose | LOC102550562 | gene expression | LOC102550562 | 0.14 | 1795 | 0.09 | 9.8e-10 | 5.87 | 4.48e-09 | 0.33 | FALSE |
| Adipose | Pak1 | gene expression | Pak1 | 0.03 | 23 | 0.01 | 1.1e-02 | 5.9 | 3.60e-09 | 0.33 | FALSE |
| Adipose | Alg8 | isoform ratio | XM_039105983.2 | 0.03 | 1 | 0.01 | 8.8e-03 | -5.49 | 4.08e-08 | 0.03 | FALSE |
| Adipose | Clns1a | isoform ratio | NM_031719.2 | 0.06 | 1 | 0.02 | 2.2e-03 | -5.77 | 8.11e-09 | 0.03 | FALSE |
| Adipose | Clns1a | isoform ratio | XM_006229792.3 | 0.06 | 1 | 0.02 | 1.9e-03 | 5.77 | 8.11e-09 | 0.03 | FALSE |
| Adipose | Kctd21 | isoform ratio | XM_039087670.2 | 0.04 | 1 | 0.02 | 1.1e-03 | 5.49 | 4.08e-08 | 0.03 | FALSE |
| Adipose | Alg8 | mRNA stability | Alg8 | 0.31 | 1 | 0.11 | 4.6e-12 | -6.07 | 1.26e-09 | 0.91 | FALSE |
| Adipose | Aqp11 | mRNA stability | Aqp11 | 0.25 | 1793 | 0.14 | 4.2e-15 | 5.67 | 1.42e-08 | 0.24 | FALSE |
| Adipose | Kctd21 | mRNA stability | Kctd21 | 0.08 | 1 | 0.05 | 7.4e-06 | -5.49 | 4.08e-08 | 0.12 | FALSE |
| BLA | B3gnt6 | alternative polyA | NM_001106211.1 | 0.06 | 1 | 0 | 2.4e-01 | -5.75 | 8.90e-09 | 0.04 | FALSE |
| BLA | B3gnt6 | alternative polyA | XM_006229745.5 | 0.05 | 1 | 0 | 3.0e-01 | 5.75 | 8.90e-09 | 0.04 | FALSE |
| BLA | Alg8 | gene expression | Alg8 | 0.39 | 9 | 0.25 | 9.4e-14 | -6.02 | 1.76e-09 | 0.66 | FALSE |
| BLA | Alg8 | isoform ratio | NM_001034127.1 | 0.12 | 1762 | 0.02 | 2.1e-02 | -5.45 | 5.12e-08 | 0.56 | FALSE |
| BLA | B3gnt6 | isoform ratio | XM_006229745.5 | 0.11 | 1 | 0.09 | 1.1e-05 | 5.75 | 8.90e-09 | 0.21 | FALSE |
| BLA | Kctd14 | isoform ratio | NM_001400257.1 | 0.06 | 1 | 0.02 | 3.5e-02 | -6.02 | 1.76e-09 | 0.06 | FALSE |
| BLA | Acer3 | mRNA stability | Acer3 | 0.07 | 1530 | 0.04 | 2.7e-03 | 5.63 | 1.76e-08 | 0.53 | FALSE |
| BLA | Alg8 | mRNA stability | Alg8 | 0.11 | 1 | 0.09 | 2.0e-05 | -6.02 | 1.76e-09 | 0.57 | FALSE |
| BLA | Nars2 | mRNA stability | Nars2 | 0.09 | 2452 | 0.07 | 1.8e-04 | -5.21 | 1.93e-07 | 0.36 | FALSE |
| Brain | Gdpd4 | alternative polyA | XM_063280972.1 | 0.03 | 1 | 0.03 | 6.4e-04 | 6.26 | 3.88e-10 | 0.27 | FALSE |
| Brain | Alg8 | gene expression | Alg8 | 0.1 | 5 | 0.08 | 1.3e-07 | -5.78 | 7.44e-09 | 0.37 | FALSE |
| Brain | Alg8 | mRNA stability | Alg8 | 0.18 | 1 | 0.16 | 4.9e-15 | -5.73 | 1.01e-08 | 0.57 | FALSE |
| Brain | Clns1a | mRNA stability | Clns1a | 0.3 | 1800 | 0.33 | 1.9e-31 | 5.97 | 2.30e-09 | 0.63 | FALSE |
| Brain | Gab2 | mRNA stability | Gab2 | 0.04 | 2081 | 0.03 | 7.8e-04 | 5.92 | 3.20e-09 | 0.55 | FALSE |
| Brain | Ints4 | mRNA stability | Ints4 | 0.14 | 1709 | 0.13 | 3.3e-12 | -5.21 | 1.86e-07 | 0.34 | FALSE |
| Brain | Ndufc2 | mRNA stability | Ndufc2 | 0.19 | 1 | 0.13 | 3.7e-12 | -5.63 | 1.75e-08 | 0.44 | FALSE |
| Brain | Pak1 | mRNA stability | Pak1 | 0.05 | 1783 | 0.03 | 3.6e-04 | -5.66 | 1.49e-08 | 0.48 | FALSE |
| IC | Alg8 | gene expression | Alg8 | 0.26 | 1762 | 0.13 | 3.7e-06 | -5.59 | 2.23e-08 | 0.7 | FALSE |
| IC | Aqp11 | gene expression | Aqp11 | 0.09 | 1793 | 0.07 | 9.1e-04 | -5.38 | 7.32e-08 | 0.49 | FALSE |
| IC | B3gnt6 | gene expression | B3gnt6 | 0.38 | 6 | 0.27 | 1.3e-11 | -5.57 | 2.60e-08 | 0.03 | FALSE |
| IC | Acer3 | mRNA stability | Acer3 | 0.1 | 4 | 0.05 | 4.1e-03 | 6.5 | 7.98e-11 | 0.69 | FALSE |
| IL | Capn5 | alternative TSS | NM_134461.2 | 0.19 | 1564 | 0.04 | 4.8e-02 | -5.36 | 8.22e-08 | 0.13 | FALSE |
| IL | Capn5 | alternative TSS | XM_063277369.1 | 0.22 | 1564 | 0.04 | 3.3e-02 | 5.25 | 1.48e-07 | 0.13 | FALSE |
| LHb | Alg8 | isoform ratio | NM_001034127.1 | 0.19 | 1 | 0.08 | 5.3e-03 | -5.69 | 1.30e-08 | 0.05 | FALSE |
| LHb | Aamdc | intron excision ratio | chr1_161281109_161287359 | 0.27 | 1648 | 0.13 | 4.5e-04 | -5.34 | 9.48e-08 | 0.26 | FALSE |
| LHb | Clns1a | mRNA stability | Clns1a | 0.19 | 1 | 0.07 | 8.6e-03 | 6.29 | 3.21e-10 | 0.06 | FALSE |
| Liver | Tsku | alternative TSS | XM_006229761.5 | 0.67 | 69 | 0.07 | 4.9e-08 | -5.66 | 1.55e-08 | 0.09 | FALSE |
| Liver | Ndufc2 | gene expression | Ndufc2 | 0.04 | 1 | 0.02 | 3.3e-03 | 5.63 | 1.75e-08 | 0.04 | FALSE |
| Liver | Thrsp | gene expression | Thrsp | 0.07 | 1 | 0.03 | 1.3e-04 | 6.04 | 1.50e-09 | 0.28 | FALSE |
| NAcc | Pak1 | alternative polyA | XM_063287516.1 | 0.02 | 1 | 0.01 | 3.0e-03 | 6.5 | 7.98e-11 | 0.24 | TRUE |
| NAcc | B3gnt6 | gene expression | B3gnt6 | 0.11 | 1563 | 0.12 | 6.4e-18 | -5.63 | 1.76e-08 | 0.16 | FALSE |
| NAcc | Clns1a | gene expression | Clns1a | 0.05 | 1800 | 0.04 | 5.4e-07 | -5.31 | 1.07e-07 | 0.13 | FALSE |
| NAcc | Ints4 | gene expression | Ints4 | 0.07 | 1 | 0.08 | 6.6e-12 | -6.2 | 5.64e-10 | 0.88 | FALSE |
| NAcc | LOC134485155 | gene expression | LOC134485155 | 0.15 | 15 | 0.21 | 5.1e-31 | 5.99 | 2.13e-09 | 0.61 | FALSE |
| NAcc | Lrrc32 | gene expression | Lrrc32 | 0.02 | 1 | 0.01 | 6.0e-03 | -5.55 | 2.87e-08 | 0.04 | FALSE |
| NAcc | Alg8 | isoform ratio | NM_001034127.1 | 0.02 | 1 | 0.01 | 1.6e-02 | -6.04 | 1.59e-09 | 0.06 | FALSE |
| NAcc | Clns1a | isoform ratio | XM_006229792.3 | 0.02 | 1 | 0.02 | 3.3e-04 | 6.11 | 1.01e-09 | 0.07 | FALSE |
| NAcc | Aamdc | mRNA stability | Aamdc | 0.13 | 47 | 0.1 | 5.1e-15 | 5.55 | 2.78e-08 | 0.53 | FALSE |
| NAcc | Alg8 | mRNA stability | Alg8 | 0.09 | 1 | 0.09 | 5.9e-13 | -5.77 | 8.09e-09 | 0.62 | FALSE |
| NAcc | Clns1a | mRNA stability | Clns1a | 0.05 | 1 | 0.06 | 2.6e-09 | 5.78 | 7.39e-09 | 0.34 | FALSE |
| NAcc | Nars2 | mRNA stability | Nars2 | 0.04 | 2452 | 0.03 | 8.0e-06 | -5.67 | 1.46e-08 | 0.66 | FALSE |
| OFC | B3gnt6 | alternative polyA | NM_001106211.1 | 0.14 | 1 | 0.06 | 1.3e-02 | -6.45 | 1.13e-10 | 0.1 | FALSE |
| OFC | B3gnt6 | alternative polyA | XM_006229745.5 | 0.14 | 1 | 0.07 | 8.2e-03 | 5.96 | 2.47e-09 | 0.05 | FALSE |
| OFC | B3gnt6 | gene expression | B3gnt6 | 0.31 | 1563 | 0.2 | 1.8e-05 | -5.84 | 5.35e-09 | 0.69 | FALSE |
| OFC | Clns1a | mRNA stability | Clns1a | 0.17 | 1 | 0.05 | 2.6e-02 | 6.29 | 3.21e-10 | 0.08 | FALSE |
| PL | Alg8 | gene expression | Alg8 | 0.15 | 1762 | 0.12 | 1.3e-12 | -6.19 | 6.06e-10 | 0.67 | FALSE |
| PL | B3gnt6 | gene expression | B3gnt6 | 0.4 | 12 | 0.45 | 1.6e-54 | -5.57 | 2.53e-08 | 0.02 | FALSE |
| PL | Thap12 | gene expression | Thap12 | 0.11 | 123 | 0.11 | 1.2e-11 | -5.28 | 1.30e-07 | 0.69 | FALSE |
| PL | Alg8 | isoform ratio | NM_001034127.1 | 0.05 | 1 | 0.04 | 2.8e-05 | -5.69 | 1.30e-08 | 0.24 | FALSE |
| PL | Clns1a | isoform ratio | NM_031719.2 | 0.04 | 1800 | 0.03 | 5.5e-04 | -5.8 | 6.69e-09 | 0.68 | FALSE |
| PL | Clns1a | isoform ratio | XM_006229792.3 | 0.04 | 1800 | 0.02 | 1.7e-03 | 5.79 | 6.96e-09 | 0.64 | FALSE |
| PL | Alg8 | mRNA stability | Alg8 | 0.09 | 1 | 0.09 | 5.3e-10 | -6.04 | 1.59e-09 | 0.89 | FALSE |
| PL | Clns1a | mRNA stability | Clns1a | 0.08 | 1800 | 0.07 | 4.5e-08 | 5.5 | 3.70e-08 | 0.81 | FALSE |
| PL | Ndufc2 | mRNA stability | Ndufc2 | 0.07 | 1756 | 0.03 | 1.2e-04 | -5.64 | 1.75e-08 | 0.6 | FALSE |
| pVTA | Alg8 | gene expression | Alg8 | 0.11 | 1 | 0.1 | 2.0e-08 | -5.56 | 2.64e-08 | 0.34 | FALSE |
| pVTA | Ints4 | gene expression | Ints4 | 0.04 | 1 | 0.02 | 1.0e-02 | 5.78 | 7.39e-09 | 0.04 | FALSE |
| pVTA | LOC102550562 | gene expression | LOC102550562 | 0.04 | 1795 | 0.01 | 3.3e-02 | 5.55 | 2.89e-08 | 0.25 | FALSE |
| pVTA | Alg8 | isoform ratio | NM_001034127.1 | 0.09 | 1 | 0.08 | 9.2e-07 | -5.69 | 1.30e-08 | 0.45 | FALSE |
| pVTA | Alg8 | isoform ratio | XM_039105983.2 | 0.06 | 1 | 0.06 | 8.6e-06 | 6.04 | 1.59e-09 | 0.58 | FALSE |
| RMTg | Ndufc2 | mRNA stability | Ndufc2 | 0.24 | 1 | 0.25 | 2.5e-07 | -5.95 | 2.69e-09 | 0.4 | FALSE |