LOC120100068

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	LOC120100068	0.31	0.12	0.0e+00	0.16	0.18	0.18	0.18	7.3e-17	1.8e-19	4.5e-19	4.4e-19
2	BLA	mRNA stability	LOC120100068	0.37	0.22	3.4e-05	0.1	0.07	0.1	0.1	3.2e-06	9.9e-05	9.8e-06	9.2e-06
3	Brain	mRNA stability	LOC120100068	0.5	0.16	0.0e+00	0.12	0.2	0.2	0.2	1.2e-11	3.1e-18	1.5e-18	1.0e-18
4	Adipose	gene expression	LOC120100068	0.03	0.02	6.2e-03	0.02	0.01	0.01	0.01	4.3e-03	2.8e-02	2.3e-02	2.5e-02
5	Brain	gene expression	LOC120100068	0.03	0.02	8.0e-03	0.01	0.01	0.01	0	4.4e-02	7.2e-02	6.5e-02	9.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.3	4.2	6.7	2.6	-2.4	1.9	1.5	1.7
Area under the delay curve	0.8	1.3	2.4	1.0	-1.2	0.6	1.2	-1.6
BMI with tail	22.1	77.1	121.8	11.0	-10.0	9.3	8.6	1.5
BMI without tail	9.5	50.6	78.8	8.9	-8.0	7.7	7.0	1.2
Body weight	17.6	77.1	122.0	11.0	-10.3	9.2	8.1	2.6
Weight adjusted by age	2.2	6.4	9.9	3.1	-2.8	3.1	2.2	0.2
Bone surface	1.7	3.3	5.3	2.3	-2.1	1.9	1.2	1.4
Bone volume	3.0	6.0	9.7	3.1	-3.0	2.4	2.1	0.9
Breakpoint value in progressive ratio session	0.1	0.2	0.7	0.3	-0.9	-0.5	-0.3	0.1
Number of licking bursts	0.2	0.6	2.8	0.0	-0.0	-0.1	-0.5	1.7
Context. condit. distance diff. score	0.2	0.2	0.4	0.3	0.3	0.7	0.1	0.6
Locomotion velocity, session 1	0.2	0.3	0.5	-0.7	0.6	-0.4	-0.5	-0.1
Locomotion distance, session 1	0.4	0.5	1.2	-0.8	1.1	-0.3	-0.3	-0.8
Locomotion velocity, session 2	1.3	1.5	3.6	-1.4	1.9	-1.0	-1.0	-0.2
Locomotion distance, session 2	0.8	1.2	2.2	1.2	-0.5	1.5	1.4	-0.4
Locomotion velocity, session 3	0.4	0.4	0.9	-0.8	0.9	-0.4	-0.5	-0.3
Locomotion distance, session 3	0.2	0.3	0.6	-0.1	0.5	0.5	0.5	-0.8
Stereotopy head waving bouts, day 3	0.9	1.0	1.6	-1.2	1.0	-1.3	-0.8	-0.8
Stereotopy head waving duration, day 3	1.2	1.5	2.6	-1.4	1.1	-1.6	-1.2	-0.3
Locomotion velocity, session 7	0.7	0.8	1.4	1.0	-0.5	1.2	0.9	0.6
Locomotion distance, session 7	1.0	1.2	2.0	1.4	-0.6	1.4	1.3	0.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.5	-0.1	-0.4	0.0	-0.1	-0.7
Stereotopy head waving duration, day 7	0.3	0.4	0.5	-0.7	-0.3	-0.7	-0.7	-0.6
Locomotion velocity, session 8	1.3	1.6	2.4	-1.1	1.4	-0.6	-1.5	1.4
Locomotion distance, session 8	0.5	0.8	1.9	0.1	1.0	1.0	-0.2	1.4
Degree of sensitization distance	0.8	0.8	1.4	1.2	-0.9	0.5	0.5	1.2
Degree of sensitization stereotypy	0.6	0.7	1.8	0.8	-1.3	1.0	0.5	-0.1
Conditioned locomotion	0.2	0.3	0.6	-0.7	0.4	-0.7	-0.5	-0.3
Cocaine response after cond. corrected	2.3	3.5	8.8	-2.0	3.0	-1.5	-1.0	-1.2
Cocaine response after cond. not corrected	3.6	5.2	11.5	-2.5	3.4	-2.2	-1.7	-0.7
Cocaine response before conditioning	0.7	0.8	1.7	-0.6	0.2	-0.8	-1.1	1.3
Saline control response	0.2	0.3	1.1	-0.4	0.3	0.2	0.4	-1.1
Bone: connectivity density	0.9	1.4	2.0	1.4	-1.2	1.1	0.6	1.4
Bone: cortical apparent density	3.5	5.6	10.5	-2.9	3.2	-2.1	-1.6	-1.3
Bone: cortical area	7.5	12.3	18.5	4.3	-4.0	4.0	2.9	1.7
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.5	-0.2	-0.1	0.4
Bone: cortical porosity	0.7	0.8	1.8	1.0	-1.3	0.4	0.3	0.8
Bone: cortical thickness	6.8	11.4	17.7	4.1	-3.3	4.2	3.2	1.3
Bone: cortical thickness	5.5	6.8	9.3	3.0	-2.7	2.9	2.9	-0.5
Bone: cortical tissue density	4.1	6.5	11.8	-3.2	3.4	-2.4	-1.8	-1.2
Condit. Reinf. active minus inactive responses	0.3	0.4	1.3	-0.2	0.6	-0.0	-0.4	1.1
Condit. Reinf. active-inactive response ratio	1.2	1.2	1.6	-1.2	1.2	-1.1	-1.3	0.8
Condit. Reinf. active responses	2.0	2.6	3.8	1.8	-1.3	1.9	1.3	1.7
Condit. Reinf. inactive responses	4.3	5.6	8.4	2.8	-2.3	2.9	2.1	1.6
Incentive salience index mean	0.3	0.4	1.0	0.5	0.2	0.7	0.5	1.0
Condit. Reinf. lever presses	0.4	0.7	1.3	0.9	-0.2	1.0	1.1	0.4
Condit. Reinf. active minus inactive responses	0.3	0.5	1.5	0.7	-1.2	0.3	0.1	0.8
Condit. Reinf. active-inactive response ratio	0.5	0.8	1.6	1.1	-1.3	0.7	0.7	0.4
Condit. Reinf. active responses	1.2	1.7	3.9	1.5	-2.0	1.0	0.6	1.0
Condit. Reinf. inactive responses	0.5	0.7	1.8	1.0	-1.3	0.6	0.3	0.5
Condit. Reinf. lever presses	1.1	1.5	2.7	1.5	-1.7	1.2	0.9	0.5
Condit. Reinf. lever reinforcers received	0.7	1.0	2.0	1.0	-1.4	0.7	0.2	1.1
Conditioned reinforcement - actives	0.5	2.0	2.8	-1.5	1.7	-1.3	-0.6	-1.6
Conditioned reinforcement - inactives	0.5	1.2	2.4	-1.2	0.5	-1.3	-1.5	-0.6
Conditioned locomotion	1.5	2.2	3.4	-1.7	1.9	-1.2	-0.5	-1.7
Patch foraging indifference point 0 sec	2.9	8.2	12.0	3.5	-3.2	3.3	2.8	0.5
Patch foraging indifference point AUC	0.3	0.8	1.3	1.0	-1.2	1.0	0.8	0.1
Delay disc. indifference point, 0s delay	0.5	0.5	1.2	0.8	-0.5	1.1	0.7	-0.2
Delay disc. indifference point, 16s delay	1.0	1.4	2.6	1.0	-1.2	0.4	1.4	-1.6
Delay disc. indifference point, 2s delay	0.4	0.5	2.1	-0.3	0.3	-0.3	0.1	-1.5
Delay disc. indifference point, 24s delay	0.8	1.3	2.1	1.1	-1.4	0.9	1.1	-1.2
Delay disc. indifference point, 4s delay	0.9	1.0	3.6	0.5	-0.6	0.2	0.8	-1.9
Delay disc. indifference point, 8s delay	0.3	0.6	1.2	0.5	-0.9	0.0	0.8	-1.1
Indifference point function ln k	0.0	0.1	0.2	0.3	-0.0	0.2	0.2	0.5
Indifference point function log k	0.0	0.1	0.2	0.3	-0.0	0.2	0.2	0.5
Patch foraging total patch changes 0 sec	3.2	9.4	13.8	3.7	-3.5	3.5	2.9	0.7
Patch foraging total patch changes 12 sec	4.8	6.4	9.3	3.1	-2.9	2.9	2.3	0.7
Patch foraging total patch changes 18 sec	1.7	3.9	7.0	2.3	-2.6	2.0	1.7	0.5
Patch foraging total patch changes 24 sec	0.5	1.6	3.1	1.4	-1.8	1.3	0.8	0.7
Patch foraging total patch changes 6 sec	4.2	7.1	9.9	3.2	-3.0	3.1	2.3	1.1
Patch foraging time to switch 0 sec	1.5	5.9	9.1	-2.9	2.5	-3.0	-2.3	-0.5
Patch foraging water rate 0 sec	2.4	9.2	13.4	3.6	-3.3	3.7	2.9	0.5
Patch foraging water rate 12 sec	1.2	4.8	7.2	2.6	-2.5	2.7	1.7	1.0
Patch foraging water rate 18 sec	1.2	2.6	4.1	2.0	-1.3	1.9	2.0	-0.3
Patch foraging water rate 24 sec	3.4	4.8	6.8	2.6	-2.1	2.4	2.6	-0.7
Patch foraging water rate 6 sec	2.1	3.1	4.2	2.0	-1.9	2.0	1.9	-0.3
Seeking ratio, delayed vs. immediate footshock	2.3	3.3	6.6	-2.3	2.6	-1.9	-1.2	0.2
Distance traveled before self-admin	1.1	2.4	5.7	-1.3	1.9	-0.9	0.3	-2.4
Distance traveled after self-admin	1.1	1.9	2.6	-1.4	1.6	-1.5	-0.4	-1.6
Extensor digitorum longus weight	2.6	10.2	17.1	3.8	-4.1	3.0	3.3	0.1
Bone: elastic displacement	0.3	0.4	1.6	-0.3	-0.2	-0.3	0.4	-1.3
Bone: elastic work	1.9	2.5	4.2	1.4	-1.2	1.5	2.1	-1.6
Bone: endosteal estimation	0.5	1.3	2.5	1.5	-1.6	0.9	0.8	0.5
Bone: endosteal perimeter	0.9	2.1	4.7	1.7	-2.2	1.1	1.2	-0.3
Epididymis fat weight	13.6	68.7	108.7	10.4	-10.2	8.4	6.8	3.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	-0.3	0.8	-0.1	0.2	0.1
Delta time in open arm before/after self-admin	0.9	1.1	2.4	-0.5	-0.0	-0.9	-1.6	1.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.1	-0.6	-0.2	-0.4	0.3
Delay discount exponential model param	1.1	1.4	3.4	-0.9	1.2	-0.5	-1.2	1.9
Extinction: sum of active levers before priming	0.3	0.4	1.5	0.7	-1.2	0.2	0.3	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.5	0.6	-0.7	0.3	0.2	-0.1
Bone: final force	5.9	9.7	15.3	3.9	-3.3	3.5	3.0	1.0
Bone: final moment	5.3	8.6	13.8	3.7	-3.1	3.2	2.8	1.1
Food consumed during 24 hour testing period	0.1	0.3	0.4	-0.3	0.6	-0.5	-0.5	0.6
Glucose	2.4	3.7	7.7	2.3	-2.8	1.6	1.7	0.1
Heart weight	7.4	11.9	17.8	4.2	-3.8	3.9	2.8	1.9
Delay discount hyperbolic model param	1.1	1.4	3.7	-0.8	1.1	-0.4	-1.1	1.9
Intermittent access intake day 1-15 change	0.1	0.8	1.0	-1.0	0.8	-1.0	-0.7	-0.9
Intermittent access intake escalation	0.2	0.8	1.2	-1.1	0.8	-1.1	-0.8	-0.8
Intermittent access intake escalation 2	0.2	0.4	0.6	-0.7	0.7	-0.7	-0.5	-0.3
Intermitt. access day 1 inactive lever presses	0.1	0.6	1.0	-0.1	-0.6	-0.9	-0.9	1.0
Intermitt. access day 15 inactive lever presses	0.1	0.4	0.8	0.7	-0.9	0.5	0.5	-0.1
Intermitt. access escalation Index	0.4	1.2	1.8	-1.1	1.1	-1.3	-1.1	0.6
Intermittent access day 1 total infusions	0.1	0.4	1.0	-0.6	0.4	-0.6	-0.4	-1.0
Intermittent access day 15 total infusions	0.6	1.6	2.4	-1.4	0.9	-1.5	-1.0	-1.3
Intermittent access terminal intake (last 3 days)	0.5	0.8	1.5	-0.9	0.4	-1.1	-0.7	-1.2
Intermittent access total infusions	0.5	0.6	0.9	-0.8	0.4	-0.9	-0.7	-0.9
Intermittent access day 1 locomotion	0.8	1.5	6.2	-0.7	0.5	-0.7	0.3	-2.5
Intermittent access day 15 total locomotion	0.2	0.6	2.2	0.1	-0.8	-0.3	0.2	-1.5
Intermittent access total locomotion	0.8	1.0	4.5	-0.3	0.2	-0.2	0.4	-2.1
Intermittent access standard deviation	0.1	0.4	0.9	-0.5	-0.4	-0.9	-0.4	-0.9
Left kidney weight	4.3	34.8	53.1	7.3	-5.9	6.9	6.1	1.2
Right kidney weight	5.3	36.7	57.6	7.6	-6.1	6.8	6.5	0.8
Cocaine induced anxiety	0.3	0.9	2.7	-1.2	1.7	-0.5	-0.2	0.0
Post-drug Anxiety	0.7	0.8	2.9	0.5	-0.0	1.0	0.2	1.7
Baseline Anxiety	0.9	1.4	2.5	1.4	-1.6	0.9	0.0	1.4
Tail length	0.0	0.2	0.7	0.4	-0.8	0.1	0.3	0.1
Length with tail	1.1	5.0	7.9	2.7	-2.8	2.2	1.8	1.3
Length without tail	1.7	8.7	14.2	3.6	-3.8	2.8	2.1	2.0
Times rat made contact with spout	0.3	0.4	0.8	0.9	-0.4	0.5	0.8	0.3
Lifetime Intake	0.4	0.5	0.7	-0.9	0.6	-0.8	-0.6	-0.8
Liver weight, left	10.1	17.4	26.5	5.2	-5.0	4.4	3.9	0.8
Liver weight, right	5.4	9.4	15.0	3.9	-3.2	3.3	3.3	0.1
Locomotor activity	0.1	0.1	0.2	-0.5	0.4	-0.3	-0.3	-0.3
Locomotor testing distance	0.3	0.7	1.2	-1.0	1.1	-0.5	-0.3	-0.9
Locomotor testing rearing	0.1	0.5	2.3	-0.4	0.2	-0.4	0.2	-1.5
Locomotion in novel chamber	0.1	0.1	0.4	0.2	0.6	0.4	0.3	0.0
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	0.5	-0.1	0.7	0.6	0.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	0.2	-0.1	0.4	0.0	0.7
Change in fecal boli incidents, locomotor task	0.8	0.9	1.4	1.2	-0.8	1.2	0.9	0.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.2	0.0	-0.3	0.0	0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.1	-0.5	-0.6	-0.1	-0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.2	-0.4	-0.4	-0.1	-0.0
Rest time, locomotor task time 1	0.5	0.8	1.4	1.0	-0.5	1.2	1.2	0.2
Distance moved, locomotor task time 1	0.1	0.3	0.3	-0.5	0.1	-0.5	-0.6	-0.6
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.1	-0.1	0.2	0.3	-0.5
Time >=10cm from walls, locomotor time 2	0.5	1.5	2.8	1.5	-1.1	1.7	1.1	0.5
Bouts of movement, locomotor time 2	0.8	2.6	4.8	-1.8	1.4	-2.2	-1.3	-1.1
Total resting periods, locomotor time 2	0.6	2.6	4.8	-1.8	1.3	-2.2	-1.2	-1.3
Rest time, locomotor task time 2	0.2	0.4	1.2	-0.4	0.4	-0.6	0.3	-1.1
Distance moved, locomotor task time 2	0.2	0.3	0.6	0.6	-0.4	0.7	0.1	0.6
Vertical activity count, locomotor time 2	0.3	0.7	1.1	0.8	-0.4	1.0	0.6	1.0
Light reinforcement 1	0.0	0.1	0.3	0.3	0.0	0.6	0.4	-0.4
Light reinforcement 2	0.1	0.3	0.9	-0.6	1.0	-0.3	-0.5	-0.1
Bone: marrow area	0.7	1.6	2.9	1.7	-1.7	1.1	0.9	0.5
Bone: maximum diameter	2.3	4.7	9.4	2.7	-3.1	1.9	1.4	1.2
Bone: maximum force	3.8	7.6	12.0	3.5	-2.7	3.3	2.5	1.3
Bone: maximum moment	3.4	6.4	10.3	3.2	-2.5	3.0	2.2	1.4
Mean time between licks in bursts	0.4	2.3	3.5	-1.2	1.0	-1.7	-1.9	1.6
Mean num. licks in bursts	0.4	1.0	2.6	0.7	-0.2	0.5	1.3	-1.6
Cd content in liver	0.8	0.9	4.0	-0.7	2.0	-0.1	-0.3	-0.2
Co content in liver	0.4	0.4	1.2	0.6	0.4	1.1	0.7	-0.1
Cu content in liver	0.5	0.6	1.0	-0.9	1.0	-0.6	-0.6	-0.6
Fe content in liver	1.1	1.4	4.4	1.0	-1.0	0.8	-0.1	2.1
K content in liver	1.1	1.1	1.5	-1.2	1.0	-1.2	-0.9	-0.8
Mg content in liver	1.4	1.6	3.5	-1.2	0.8	-1.4	-0.7	-1.9
Mn content in liver	0.3	0.3	0.6	0.5	-0.8	0.3	0.4	-0.7
Na content in liver	0.4	0.5	1.8	0.2	-0.4	-0.4	0.4	-1.3
Rb content in liver	0.4	0.5	0.7	-0.8	0.1	-0.8	-0.8	-0.7
Se content in liver	0.3	0.4	0.6	-0.5	0.7	-0.1	-0.7	0.8
Sr content in liver	2.5	2.1	3.8	-1.7	2.0	-1.4	-1.1	-0.9
Zn content in liver	1.6	1.9	4.1	-1.3	1.5	-1.1	-0.3	-2.0
Bone: minimum diameter	3.7	7.2	10.8	3.3	-3.2	3.0	2.3	0.8
Time in familiar zone, hab. session 1	2.1	2.3	3.1	1.5	-1.6	1.4	1.8	-1.2
Time in novel zone, hab. session 1	1.9	2.2	3.4	-1.5	1.2	-1.4	-1.8	1.3
Total zone transitions, hab. session 1	1.5	2.2	3.1	1.5	-1.4	1.7	1.8	-0.9
Total locomotion distance, hab. session 1	0.3	0.4	1.7	0.3	-0.2	0.4	-0.3	1.3
Locomotion velocity, hab. session 1	0.3	0.4	1.5	0.4	-0.1	0.4	-0.2	1.2
Time in familiar zone, hab. session 2	0.5	0.5	1.7	0.0	-0.4	-0.4	-0.7	1.3
Time in novel zone, hab. session 2	0.3	0.4	1.2	0.0	0.3	0.4	0.6	-1.1
Total zone transitions, hab. session 2	0.2	0.3	0.9	0.4	-0.4	0.4	0.5	-0.9
Total locomotion distance, hab. session 2	0.5	0.7	1.1	1.1	-0.9	1.0	0.7	0.3
Locomotion velocity, hab. session 2	0.5	0.7	1.1	1.1	-0.9	0.9	0.8	0.0
Novel to familiar place preference ratio	0.5	0.6	2.0	-0.4	0.2	0.0	-0.9	1.4
Novelty place preference	0.4	0.5	1.4	-0.5	0.3	-0.1	-0.9	1.2
Time in novel zone, NPP test	0.5	0.6	2.3	-0.2	-0.2	0.1	-0.8	1.5
Total zone transitions, NPP test	0.6	0.8	1.3	1.2	-0.9	1.0	1.1	-0.1
Total locomotion distance, NPP test	0.5	0.7	1.2	1.0	-0.5	1.1	0.5	0.9
Locomotion velocity, NPP test	0.2	0.3	0.7	0.7	-0.0	0.8	0.3	0.6
Intraocular pressure	0.4	0.6	1.5	0.5	-1.1	0.5	-0.4	1.2
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.0	-0.4	-0.4	-0.2	-0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.6	0.3	-0.7	-0.2	-0.2	0.1
Parametrial fat weight	17.6	41.5	66.9	8.2	-8.1	6.2	5.4	2.8
Pavlov. Cond. lever latency	1.2	1.5	2.4	-1.4	0.8	-1.5	-1.6	0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.6	0.7	-0.4	0.6	0.6	0.1
Pavlov. Cond. change in total contacts	1.6	1.7	2.5	1.6	-1.4	1.3	1.5	-0.2
Pavlov. Cond. index score	0.9	1.2	1.7	1.3	-1.0	1.2	1.3	-0.1
Pavlov. Cond. latency score	0.8	1.0	1.5	1.2	-0.8	1.1	1.2	-0.1
Pavlov. Cond. lever contacts	1.1	1.3	1.9	1.3	-1.1	1.2	1.4	-0.4
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	-0.8	0.6	-0.5	-0.8	0.2
Pavlov. Cond. intertrial magazine entries	3.2	3.8	5.9	2.4	-1.7	2.4	2.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.9	1.4	-1.1	1.2	1.3	0.1
Pavlov. Cond. response bias	0.4	0.5	0.9	0.9	-0.6	0.7	1.0	-0.3
Pavlov. Cond. lever latency	0.3	0.4	1.0	-0.4	0.8	-0.1	0.5	-1.0
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.4	-0.1	-0.8	-0.9	0.4
Pavlov. Cond. change in total contacts	0.1	0.2	0.6	-0.1	-0.3	-0.4	-0.7	0.6
Pavlov. Cond. index score	0.2	0.3	0.6	0.2	-0.7	-0.1	-0.5	0.8
Pavlov. Cond. latency score	0.2	0.3	0.7	0.1	-0.6	-0.2	-0.6	0.8
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.5	-0.8	0.4	-0.1	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.1	0.3	0.3	0.5	-0.2
Pavlov. Cond. intertrial magazine entries	1.3	2.9	4.4	2.1	-1.8	1.8	1.9	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.1	-0.6	-0.1	-0.5	0.6
Pavlov. Cond. response bias	0.3	0.4	1.1	0.2	-0.7	-0.0	-0.6	1.1
Time in closed arm before self-admin	0.2	0.3	0.5	0.6	-0.7	0.6	0.4	-0.5
Time in closed arm after self-admin	0.4	0.4	1.4	-0.4	0.6	-0.2	0.4	-1.2
Time in open arm before self-admin	1.5	1.8	3.3	-1.8	1.7	-1.3	-1.0	-0.1
Time in open arm after self-admin	1.5	1.7	3.1	-1.1	0.5	-1.2	-1.7	1.5
Bone: periosteal estimation	3.8	9.0	14.4	3.8	-3.5	3.3	2.5	1.2
Bone: periosteal perimeter	4.8	9.4	16.0	3.7	-4.0	3.0	2.8	0.3
Bone: post-yield work	1.1	1.9	5.0	1.4	-0.8	1.4	0.2	2.2
Progressive ratio test 1 active lever presses	1.0	1.7	2.6	-1.5	1.0	-1.6	-1.1	-1.3
Progressive ratio test 1 breakpoint	0.9	1.6	2.4	-1.4	1.0	-1.6	-1.1	-1.2
Progressive ratio test 1 inactive lever presses	0.1	0.4	1.1	-0.5	-0.1	-0.6	-1.0	-0.4
Progressive ratio test 2 active lever presses	0.3	0.4	1.9	0.0	-0.5	-0.2	0.1	-1.4
Progressive ratio test 2 breakpoint	0.3	0.4	1.9	0.0	-0.5	-0.2	0.1	-1.4
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.3	-0.0	-0.3	-0.2	-0.6	0.2
Incentive Sensitization - Responses	0.3	0.9	1.6	0.8	-1.2	0.5	0.7	-1.2
Incentive Sensitization - Breakpoint	0.4	0.8	1.5	0.8	-1.2	0.4	0.6	-1.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.2	-0.4	-0.0	-1.1	-1.0	-0.1
Progressive ratio	1.5	4.5	7.5	-2.7	2.3	-2.2	-2.3	0.2
Food seeking constrained by brief footshock	2.2	2.7	5.0	-2.2	1.6	-1.4	-2.0	0.1
Seeking ratio, punishment vs. effort	0.5	1.0	1.4	1.1	-0.9	1.2	1.1	-0.7
Retroperitoneal fat weight	23.6	105.7	166.7	12.9	-12.3	10.7	8.7	4.4
Reaction time number correct	0.1	0.5	1.2	-0.6	-0.2	-1.1	-0.5	-0.9
Reaction time mean minus median	0.1	0.8	2.3	0.4	-0.9	0.1	0.8	-1.5
Reaction time mean minus median AUC	0.3	1.9	8.4	-0.1	-0.5	-0.6	0.8	-2.9
Reaction time num false alarms	0.8	1.4	2.3	1.4	-0.8	1.5	1.4	0.1
Reaction time num false alarms AUC	0.6	1.3	2.1	1.3	-0.7	1.4	1.5	-0.3
Reaction time trials correct on left	0.1	0.5	1.2	-0.6	-0.2	-1.1	-0.5	-0.9
Reaction time trials on left	0.2	0.6	1.3	-0.6	-0.3	-1.1	-0.5	-0.9
Reaction time mean	1.0	2.2	6.5	-1.3	0.5	-1.5	-0.4	-2.5
Reaction time mean AUC	1.1	2.6	7.9	-1.4	0.6	-1.7	-0.4	-2.8
Median of all reaction times	1.9	2.9	7.1	-1.7	0.9	-1.9	-0.6	-2.7
Reaction time omissions	0.2	0.3	0.7	0.1	-0.8	-0.6	-0.1	-0.7
Reaction time false alarm rate	1.3	1.8	3.7	1.6	-0.6	1.9	1.5	0.6
Reaction time premature initiation rate	0.8	1.2	2.0	1.1	-0.8	1.4	1.4	-0.4
Reaction time premature initiations	0.2	0.7	1.1	0.7	-0.9	0.7	1.0	-0.8
Std. dev. reaction times	0.3	0.9	2.6	0.5	-1.1	0.1	0.7	-1.6
Reaction time trials completed	0.2	0.6	1.3	-0.6	-0.3	-1.1	-0.5	-0.9
Reaction time trials AUC	0.1	0.4	0.9	-0.4	-0.4	-1.0	-0.4	-0.8
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.2	-0.2	-0.3	-0.2	-0.3
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.4	0.5	0.2	0.1	-0.7
Latency to leave start box in cocaine runway	2.6	3.5	6.0	-2.3	1.2	-2.4	-2.2	-0.3
Latency to leave start box in cocaine runway, F	1.1	1.4	2.9	-1.3	0.5	-1.4	-1.7	0.2
Latency to leave start box in cocaine runway, M	0.9	0.8	1.5	-1.1	0.6	-1.2	-0.8	-0.6
Std. dev. time between licks in bursts	0.9	1.8	2.7	-1.1	1.3	-0.9	-1.6	1.5
Total sessions with >9 infusions	0.2	0.3	1.1	-0.4	0.1	-0.1	-0.1	-1.0
Short access day 1 total inactive lever presses	0.3	0.7	1.6	-0.6	0.5	-0.5	-0.9	1.3
Short access day 10 total inactive lever presses	0.2	1.3	2.1	1.4	-1.3	1.3	1.1	0.2
Short access day 1 total infusions	0.1	0.1	0.5	-0.2	-0.1	-0.1	-0.1	-0.7
Short access day 10 total infusions	1.5	2.5	3.5	-1.9	1.7	-1.6	-1.1	-1.6
Short access total infusions	0.7	0.9	1.4	-1.2	1.1	-0.9	-0.7	-0.9
Short access day 1 locomotion	0.5	0.8	3.1	-0.4	-0.0	-0.7	-0.1	-1.8
Short access day 10 total locomotion	0.2	0.9	4.0	-0.2	0.1	-0.4	0.4	-2.0
Short access total locomotion	1.0	1.6	5.8	-0.9	0.8	-0.8	0.1	-2.4
One hour access (0.3 mA shock)	0.8	0.9	1.9	-1.1	0.4	-1.4	-1.1	-0.4
Compulsive drug intake	0.3	0.4	1.1	0.6	-0.6	0.4	0.3	1.0
One hour access (shock baseline)	0.7	1.7	2.4	-1.5	1.2	-1.5	-1.3	-1.0
Social response proportion	1.8	2.3	3.3	1.7	-1.4	1.7	1.8	-0.6
Social responses	2.9	3.9	5.7	2.4	-2.3	2.2	1.9	0.6
Social time	0.4	0.7	2.7	0.1	-0.4	-0.3	0.6	-1.6
Soleus weight	3.3	9.7	14.5	3.2	-3.3	2.1	3.8	-2.9
Bone: stiffness	2.0	3.6	5.9	2.3	-1.7	2.4	1.5	1.4
Tibialis anterior weight	0.5	1.6	3.9	1.1	-2.0	0.4	1.3	-1.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.7	-0.4	0.6	0.4	0.2
Time to tail flick, vehicle, after self-admin	0.2	0.5	1.2	0.4	-0.5	0.8	0.2	1.1
Time to tail flick, test, before self-admin	0.7	0.8	3.0	-0.5	0.7	-0.4	0.5	-1.7
Time to tail flick, test, after self-admin	0.8	0.8	0.9	-0.8	0.7	-1.0	-1.0	1.0
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	1.0	0.3	-0.7	0.2	-0.0	1.0
Delta time to tail flick, test, before/after SA	0.6	0.7	2.9	-0.1	0.2	-0.1	-0.8	1.7
Tibia length	0.5	1.4	2.8	1.4	-0.9	1.7	1.3	0.1
Ambulatory time before self-admin	0.5	1.7	4.0	-1.0	1.6	-0.6	0.6	-2.0
Ambulatory time after self-admin	0.7	1.2	2.5	-1.0	1.0	-1.1	0.0	-1.6
Bone: tissue strength	0.7	0.7	1.1	-1.0	0.8	-0.9	-1.0	0.4
Total heroin consumption	2.1	2.5	5.2	2.0	-2.3	1.2	1.3	0.0
Bone: trabecular number	1.6	3.0	4.2	2.0	-2.0	1.6	0.9	1.8
Bone: trabecular spacing	2.4	3.5	5.5	-2.3	2.1	-2.1	-1.8	-0.1
Bone: trabecular thickness	5.9	8.2	12.9	3.6	-3.5	2.8	2.6	0.9
Bone: trabecular tissue density	1.6	2.8	3.9	-2.0	1.9	-1.9	-1.1	-1.2
Water consumed over 24 hours	0.1	0.1	0.3	0.2	0.2	-0.1	0.6	-0.4
Number of responses in last shaping day	0.1	0.1	0.3	-0.4	0.1	-0.3	-0.1	-0.5