Hub : Genes

Emx2os

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Emx2os 0.3 0.13 2.3e-07 0.11 0.11 0.12 0.12 1.9e-06 3.1e-06 9.6e-07 1.1e-06
2 Eye mRNA stability Emx2os 0.71 0.14 6.8e-05 0.06 0.17 0.18 0.2 4.8e-02 1.4e-03 1.2e-03 5.6e-04
3 Adipose mRNA stability Emx2os 0.19 0.07 0.0e+00 0.15 0.14 0.14 0.15 2.3e-16 7.3e-15 2.9e-15 2.0e-16
4 PL mRNA stability Emx2os 0.22 0.09 2.9e-12 0.12 0.1 0.12 0.12 8.7e-13 1.9e-11 3.0e-13 3.1e-13
5 pVTA gene expression Emx2os 0.25 0.13 7.0e-09 0.12 0.09 0.09 0.1 1.0e-09 1.2e-07 5.7e-08 2.6e-08
6 BLA gene expression Emx2os 0.38 0.12 3.9e-14 0.21 0.2 0.2 0.2 3.7e-11 4.0e-11 8.3e-11 4.3e-11
7 Adipose intron excision ratio chr1_268557371_268612388 0.03 0.02 4.8e-03 0.01 0.01 0 0.01 1.7e-02 3.2e-02 3.1e-01 2.0e-02
8 PL gene expression Emx2os 0.43 0.13 0.0e+00 0.31 0.27 0.3 0.31 4.9e-34 7.0e-30 2.3e-33 5.9e-35
9 IC gene expression Emx2os 0.57 0.11 0.0e+00 0.39 0.35 0.35 0.39 1.1e-17 2.2e-15 1.9e-15 2.4e-17
10 NAcc mRNA stability Emx2os 0.07 0.03 5.8e-08 0.07 0.06 0.06 0.07 1.6e-10 5.1e-09 6.2e-09 3.0e-10
11 NAcc intron excision ratio chr1_268551133_268612388 0.03 0.02 1.5e-03 0.01 0.02 0.01 0.01 1.0e-02 8.8e-04 3.2e-03 4.6e-03
12 Brain mRNA stability Emx2os 0.26 0.1 1.4e-14 0.16 0.17 0.17 0.17 5.0e-15 2.6e-15 1.8e-15 2.5e-15
13 Brain gene expression Emx2os 0.37 0.1 0.0e+00 0.29 0.3 0.29 0.3 1.1e-27 1.8e-28 1.4e-27 2.7e-28
14 NAcc gene expression Emx2os 0.38 0.12 0.0e+00 0.26 0.26 0.26 0.27 1.4e-39 2.9e-39 2.7e-39 2.4e-40
15 OFC gene expression Emx2os 0.6 0.16 3.4e-05 0.17 0.15 0.17 0.2 9.3e-05 1.8e-04 8.6e-05 1.6e-05
16 Brain intron excision ratio chr1_268551133_268612388 0.05 0.03 9.4e-04 0.02 0.02 0.02 0.01 6.9e-03 7.3e-03 5.3e-03 1.6e-02
17 pVTA intron excision ratio chr1_268557371_268612388 0.1 0.05 3.9e-06 0.06 0.07 0.06 0.07 3.0e-05 4.2e-06 9.7e-06 3.6e-06
18 OFC mRNA stability Emx2os 0.32 0.15 1.2e-03 0.03 0.1 0.06 0.04 7.3e-02 2.1e-03 1.6e-02 5.2e-02
19 Adipose gene expression Emx2os 0.18 0.08 8.3e-16 0.14 0.14 0.16 0.14 1.9e-15 7.7e-15 3.0e-17 1.2e-15
20 IC intron excision ratio chr1_268551133_268612388 0.09 0.07 5.6e-03 0 0.02 0.02 0 3.1e-01 3.5e-02 3.5e-02 3.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density1.22.06.6-2.2-2.5-1.6-1.4-1.1-1.4-1.4-1.4-1.2-1.2-2.6-1.0-0.8-0.8-0.7-1.9-0.20.30.5-1.3
Area under the delay curve1.61.85.5-1.3-1.4-1.2-1.2-1.0-0.9-1.2-1.1-1.2-1.10.3-1.3-1.6-1.4-1.91.1-1.2-2.3-2.10.5
BMI with tail15.352.7104.6-10.2-8.8-9.1-8.5-8.5-8.4-8.3-8.3-8.5-8.3-5.2-7.7-7.5-7.4-6.2-3.1-6.0-2.5-2.80.6
BMI without tail11.334.565.3-8.1-6.7-7.3-6.9-7.0-6.8-6.8-6.7-6.9-6.9-4.1-6.3-6.1-6.1-5.0-2.7-4.9-1.7-2.30.6
Body weight10.947.7103.3-10.2-9.6-8.6-8.0-7.8-7.9-7.7-7.8-7.6-7.7-6.3-6.9-6.9-6.6-5.7-3.7-4.8-2.1-1.9-0.9
Weight adjusted by age2.84.27.3-2.7-1.8-2.4-2.6-2.6-2.5-2.1-2.6-2.6-2.0-1.2-2.2-2.6-2.0-1.5-1.5-2.1-0.6-0.60.3
Bone surface0.91.65.0-1.9-2.0-1.5-1.3-1.2-1.3-1.2-1.3-1.2-1.1-2.2-0.9-0.7-0.8-0.7-1.8-0.30.50.6-0.9
Bone volume2.03.78.5-2.9-2.9-2.4-2.2-2.0-2.1-2.1-2.2-2.0-2.0-2.1-1.8-1.7-1.7-1.6-1.4-1.1-0.5-0.4-0.5
Breakpoint value in progressive ratio session0.30.43.1-0.6-1.8-0.10.40.00.10.10.20.30.1-0.70.3-0.00.2-0.20.80.6-0.8-0.2-0.9
Number of licking bursts0.60.93.30.1-0.60.60.60.60.50.70.50.80.7-1.80.91.01.00.6-1.21.31.21.2-1.6
Context. condit. distance diff. score0.20.21.60.20.30.0-0.1-0.0-0.10.1-0.1-0.4-0.2-0.2-0.00.1-0.10.5-0.8-0.21.21.00.2
Locomotion velocity, session 10.30.31.60.71.31.00.40.50.40.60.40.50.60.40.40.40.50.5-0.10.30.00.2-0.3
Locomotion distance, session 10.30.43.40.81.90.50.20.20.20.50.10.40.61.00.10.2-0.00.20.2-0.10.2-0.51.0
Locomotion velocity, session 20.91.13.91.72.01.01.10.80.81.00.91.11.01.10.90.90.81.10.10.61.30.50.9
Locomotion distance, session 20.81.12.1-1.00.3-1.4-1.3-1.4-1.4-1.2-1.4-0.9-1.10.1-1.2-1.1-1.2-0.8-0.4-1.00.3-0.81.3
Locomotion velocity, session 30.30.42.40.91.60.90.30.40.40.70.30.40.70.70.30.40.40.50.30.20.40.20.3
Locomotion distance, session 30.30.42.40.31.60.1-0.6-0.5-0.6-0.3-0.7-0.3-0.30.9-0.6-0.4-0.4-0.20.0-0.60.2-0.30.9
Stereotopy head waving bouts, day 30.30.40.80.80.60.50.90.70.70.70.80.60.60.90.60.40.4-0.00.80.2-0.5-0.40.6
Stereotopy head waving duration, day 30.70.81.81.00.30.71.31.31.21.01.31.21.00.31.10.91.00.30.70.9-0.2-0.10.0
Locomotion velocity, session 70.30.41.0-0.50.0-0.6-0.6-0.8-0.8-0.9-0.7-0.6-1.0-0.7-0.6-0.5-0.5-0.1-0.6-0.30.80.2-0.1
Locomotion distance, session 70.70.82.0-0.8-0.1-1.1-1.1-1.4-1.3-1.2-1.2-1.0-1.1-0.2-1.0-0.9-1.0-0.1-0.4-0.80.90.00.7
Stereotopy head waving bouts, day 70.20.21.3-0.3-0.4-0.1-0.1-0.2-0.20.1-0.1-0.30.1-0.2-0.2-0.3-0.3-1.20.5-0.3-1.1-1.1-0.0
Stereotopy head waving duration, day 70.30.32.10.0-0.80.40.50.40.50.60.50.30.5-0.20.30.20.3-0.80.90.3-1.4-0.7-0.6
Locomotion velocity, session 81.82.25.21.71.41.61.41.31.51.61.41.01.4-0.51.51.71.51.6-1.21.12.22.3-0.7
Locomotion distance, session 80.71.07.60.81.60.50.20.10.10.50.20.10.3-0.60.40.70.41.3-1.90.32.81.70.2
Degree of sensitization distance0.40.42.0-0.8-1.4-0.8-0.2-0.5-0.4-0.5-0.2-0.5-0.5-1.1-0.1-0.2-0.30.3-0.6-0.10.70.5-0.5
Degree of sensitization stereotypy0.60.72.1-1.1-1.0-0.4-0.7-0.8-0.7-0.4-0.7-0.9-0.5-1.1-0.7-0.7-0.6-1.5-0.2-0.5-1.1-0.9-0.7
Conditioned locomotion0.10.20.50.5-0.10.40.50.60.60.40.60.10.30.40.30.30.2-0.10.70.0-0.5-0.2-0.1
Cocaine response after cond. corrected1.72.07.22.22.60.91.21.31.31.01.31.01.02.70.80.80.71.50.80.11.20.22.2
Cocaine response after cond. not corrected3.03.58.02.82.81.81.92.01.91.91.91.81.92.51.61.61.52.30.90.91.70.91.4
Cocaine response before conditioning1.31.63.70.7-0.01.71.11.11.01.51.01.51.5-0.91.31.21.41.4-0.11.70.71.4-1.9
Saline control response0.30.41.90.11.40.1-0.5-0.3-0.5-0.3-0.5-0.4-0.20.8-0.5-0.4-0.4-0.60.3-0.7-0.8-1.10.6
Bone: connectivity density0.40.73.3-1.0-1.1-0.7-0.6-0.3-0.6-0.6-0.6-0.4-0.4-1.8-0.2-0.0-0.10.1-1.70.30.80.9-1.2
Bone: cortical apparent density2.23.013.12.93.62.21.61.61.71.41.61.41.22.61.21.31.11.21.40.40.60.11.2
Bone: cortical area4.67.113.7-3.7-3.6-3.2-3.0-3.0-2.9-3.1-2.9-3.0-2.8-3.4-2.5-2.2-2.4-2.4-2.4-1.6-0.1-0.2-0.8
Bone: cortical porosity0.10.10.8-0.4-0.9-0.20.20.10.00.10.1-0.00.1-0.50.10.1-0.10.00.30.2-0.00.2-0.4
Bone: cortical porosity0.40.42.6-1.1-1.6-0.7-0.3-0.4-0.4-0.3-0.3-0.4-0.3-1.3-0.2-0.3-0.4-0.4-0.30.1-0.20.1-0.8
Bone: cortical thickness4.47.311.4-3.3-2.3-3.2-3.3-3.3-3.2-3.3-3.2-3.4-3.1-2.8-2.8-2.4-2.7-2.4-2.5-2.20.3-0.5-0.1
Bone: cortical thickness5.36.210.3-2.8-1.7-3.1-2.9-3.1-2.9-3.1-2.9-2.8-3.2-1.1-2.7-2.7-2.7-2.7-0.8-2.4-1.1-1.91.0
Bone: cortical tissue density2.63.613.93.13.72.41.91.81.91.61.91.61.52.71.41.51.31.51.50.60.70.31.1
Condit. Reinf. active minus inactive responses0.70.82.30.71.10.70.70.60.60.40.70.70.5-0.50.80.80.91.2-1.40.81.51.5-0.6
Condit. Reinf. active-inactive response ratio1.71.82.71.31.31.31.51.41.41.11.51.61.10.01.51.51.51.6-0.81.41.31.6-0.6
Condit. Reinf. active responses0.91.15.7-1.1-0.2-0.9-0.9-1.0-0.9-1.1-0.9-0.7-1.0-1.9-0.5-0.5-0.40.0-2.4-0.11.21.1-0.8
Condit. Reinf. inactive responses2.22.66.1-2.1-1.3-1.8-1.9-2.0-1.8-1.8-1.8-1.8-1.6-2.5-1.4-1.4-1.3-1.1-2.3-0.90.50.1-0.7
Incentive salience index mean0.30.42.20.11.1-0.1-0.0-0.1-0.2-0.4-0.10.1-0.3-0.40.10.20.20.8-1.40.21.51.0-0.1
Condit. Reinf. lever presses0.30.41.1-0.50.6-0.7-0.5-0.8-0.8-1.0-0.6-0.5-0.8-0.0-0.5-0.6-0.50.3-0.6-0.50.70.10.4
Condit. Reinf. active minus inactive responses0.30.42.6-0.8-1.6-0.4-0.1-0.1-0.1-0.2-0.10.1-0.3-1.30.20.10.2-0.2-0.90.6-0.30.5-1.2
Condit. Reinf. active-inactive response ratio0.40.52.3-1.1-1.5-0.8-0.6-0.6-0.6-0.7-0.6-0.6-0.7-1.0-0.5-0.5-0.4-0.7-0.6-0.2-0.4-0.0-0.6
Condit. Reinf. active responses0.70.95.4-1.6-2.3-0.8-0.7-0.6-0.7-0.6-0.7-0.2-0.7-1.9-0.3-0.4-0.2-0.6-0.90.4-0.50.3-1.4
Condit. Reinf. inactive responses0.30.42.1-1.1-1.4-0.5-0.5-0.4-0.6-0.4-0.60.1-0.5-1.1-0.2-0.3-0.2-0.3-0.10.4-0.3-0.1-0.8
Condit. Reinf. lever presses0.71.03.1-1.6-1.8-1.2-1.1-0.9-1.1-1.0-1.1-0.6-1.1-1.3-0.8-0.7-0.7-1.0-0.6-0.1-0.4-0.0-0.6
Condit. Reinf. lever reinforcers received0.40.63.2-1.0-1.8-0.4-0.3-0.2-0.3-0.2-0.30.1-0.3-1.70.10.00.2-0.2-0.90.7-0.00.6-1.5
Conditioned reinforcement - actives0.50.83.81.41.90.90.70.60.60.60.60.70.61.60.40.70.40.31.20.20.1-0.71.0
Conditioned reinforcement - inactives0.60.81.41.10.11.21.11.11.11.01.11.11.10.11.01.21.00.50.71.1-0.20.2-0.8
Conditioned locomotion0.81.06.31.62.51.20.70.60.60.90.70.80.81.70.50.70.50.40.70.10.2-0.61.1
Patch foraging indifference point 0 sec2.95.410.2-3.2-2.3-2.7-2.8-2.8-2.8-2.7-2.8-2.5-2.8-2.1-2.4-2.3-2.2-2.3-1.9-1.6-0.7-1.00.0
Patch foraging indifference point AUC0.50.81.7-1.1-0.9-0.6-1.1-0.7-0.9-0.9-1.0-1.3-0.7-0.9-0.9-0.6-0.7-1.3-0.3-0.8-1.0-0.5-0.7
Delay disc. indifference point, 0s delay0.70.81.5-0.8-0.3-1.0-1.0-0.8-0.8-0.9-1.0-1.2-0.80.2-1.1-1.1-1.1-1.00.1-1.2-0.6-0.70.8
Delay disc. indifference point, 16s delay1.41.64.7-1.3-1.2-1.1-1.1-1.1-0.9-1.2-1.0-1.1-1.20.2-1.2-1.5-1.3-1.70.7-1.1-2.2-2.10.5
Delay disc. indifference point, 2s delay0.70.83.4-0.00.1-0.3-0.3-0.2-0.1-0.2-0.3-0.6-0.21.5-0.6-0.9-0.8-0.91.8-1.1-1.5-1.51.3
Delay disc. indifference point, 24s delay1.21.33.1-1.4-1.5-1.1-1.1-0.9-0.9-1.2-1.0-1.1-1.0-0.5-1.1-1.2-1.0-1.7-0.1-0.8-1.8-1.7-0.1
Delay disc. indifference point, 4s delay1.01.03.8-0.8-1.2-0.7-0.8-0.5-0.6-0.6-0.7-0.8-0.50.6-0.9-1.1-0.9-1.50.8-0.9-1.9-1.90.6
Delay disc. indifference point, 8s delay0.91.14.2-0.9-1.1-0.8-0.8-0.7-0.6-0.8-0.7-0.8-0.80.3-0.9-1.1-1.0-1.51.2-0.9-2.1-1.80.3
Indifference point function ln k0.10.10.8-0.00.3-0.30.1-0.4-0.20.1-0.00.2-0.2-0.00.1-0.1-0.10.6-0.50.10.90.40.5
Indifference point function log k0.10.10.8-0.00.3-0.30.1-0.4-0.20.1-0.00.2-0.2-0.00.1-0.1-0.10.6-0.50.10.90.40.5
Patch foraging total patch changes 0 sec3.36.111.7-3.4-2.6-2.9-3.0-3.0-3.0-2.8-2.9-2.6-2.9-2.4-2.5-2.5-2.3-2.4-2.0-1.7-0.7-1.0-0.1
Patch foraging total patch changes 12 sec3.14.08.2-2.9-2.2-2.1-2.4-2.3-2.4-2.3-2.4-2.3-2.1-2.2-2.1-1.8-1.8-2.0-1.6-1.3-0.7-0.7-0.6
Patch foraging total patch changes 18 sec1.62.55.1-2.3-2.0-1.4-1.9-1.7-1.7-1.7-1.8-1.8-1.7-1.8-1.5-1.4-1.2-1.6-1.2-1.0-1.2-0.4-1.0
Patch foraging total patch changes 24 sec0.50.93.1-1.4-1.5-0.6-1.0-0.9-0.9-0.7-0.9-1.0-0.6-1.8-0.7-0.7-0.6-1.1-0.9-0.3-0.7-0.1-1.1
Patch foraging total patch changes 6 sec2.84.38.7-2.9-2.4-2.2-2.4-2.1-2.4-2.4-2.4-2.1-2.3-2.9-1.9-1.8-1.5-2.1-2.2-1.0-0.6-0.5-1.1
Patch foraging time to switch 0 sec2.14.27.22.71.22.12.62.42.72.22.62.72.51.82.31.82.02.11.41.90.50.90.2
Patch foraging water rate 0 sec3.06.411.1-3.3-1.8-2.9-3.1-3.1-3.1-2.8-3.1-3.1-2.9-2.1-2.8-2.5-2.5-2.6-1.8-2.2-0.8-1.20.0
Patch foraging water rate 12 sec1.32.85.3-2.3-1.7-1.7-2.0-1.9-1.9-1.7-1.9-2.1-1.7-2.3-1.7-1.5-1.4-1.7-1.5-1.2-0.4-0.3-0.7
Patch foraging water rate 18 sec1.62.54.3-1.9-0.7-2.0-1.8-1.8-2.1-1.8-1.9-1.7-1.9-0.3-1.8-1.8-1.8-1.4-0.1-1.6-0.4-1.41.1
Patch foraging water rate 24 sec3.54.98.9-2.7-1.6-3.0-2.5-2.6-2.7-2.6-2.7-2.2-2.4-0.3-2.4-2.6-2.4-2.30.1-2.0-1.2-1.91.5
Patch foraging water rate 6 sec1.92.74.3-2.0-1.0-2.1-1.9-2.1-1.9-1.8-1.9-2.0-1.8-0.5-1.9-1.9-1.9-1.6-0.1-1.7-0.8-1.30.7
Seeking ratio, delayed vs. immediate footshock2.32.96.42.52.31.81.71.91.91.51.81.81.61.21.72.01.72.1-0.11.31.80.90.2
Distance traveled before self-admin1.11.57.91.12.50.2-0.00.1-0.1-0.2-0.0-0.0-0.32.8-0.4-0.5-0.5-0.31.9-1.0-0.7-1.52.3
Distance traveled after self-admin0.91.16.11.22.00.60.40.50.20.20.30.40.22.50.00.1-0.10.12.2-0.4-0.7-1.21.6
Extensor digitorum longus weight1.87.014.7-3.8-2.8-2.7-3.2-3.2-3.1-3.0-3.1-3.0-3.1-1.4-2.9-2.8-2.8-2.3-0.5-2.2-2.0-1.5-0.4
Bone: elastic displacement0.60.63.1-0.10.2-0.4-0.4-0.5-0.7-0.5-0.6-0.4-0.50.9-0.6-0.7-0.6-1.01.3-0.7-1.3-1.80.8
Bone: elastic work2.93.86.7-1.6-0.3-2.1-2.0-2.2-2.2-2.1-2.2-2.0-2.10.7-2.1-2.2-2.2-2.30.8-2.1-1.6-2.61.8
Bone: endosteal estimation0.30.73.5-1.4-1.9-1.3-0.8-0.9-0.8-0.7-0.8-0.6-0.7-1.1-0.6-0.7-0.6-0.6-0.5-0.3-0.30.1-0.3
Bone: endosteal perimeter0.91.97.0-2.0-2.6-1.8-1.3-1.4-1.3-1.4-1.3-1.2-1.3-0.8-1.3-1.3-1.3-1.70.3-0.9-1.4-0.70.1
Epididymis fat weight11.439.1110.9-9.4-10.5-7.6-7.0-6.7-6.8-6.7-6.8-6.8-6.5-7.1-5.9-5.8-5.5-4.7-3.4-3.7-1.5-0.7-2.2
Delta time in closed arm before/after self-admin0.30.31.00.60.90.20.20.30.30.40.30.30.20.40.30.20.30.8-1.0-0.01.00.80.6
Delta time in open arm before/after self-admin1.81.84.70.5-1.21.11.31.41.31.21.31.41.4-1.31.51.51.51.40.11.90.71.3-2.2
Diff in mean of infusions in LGA sessions0.10.11.1-0.3-1.00.10.10.00.00.30.00.00.4-0.50.00.10.0-0.40.60.2-0.70.2-0.5
Delay discount exponential model param1.71.96.21.31.51.21.21.00.91.11.11.21.0-0.41.31.61.42.0-1.21.22.52.3-0.6
Extinction: sum of active levers before priming0.30.41.6-1.0-1.1-0.4-0.4-0.5-0.5-0.5-0.4-0.4-0.6-0.1-0.4-0.7-0.4-0.40.5-0.2-1.3-0.3-0.6
Active lever presses in extinction session 60.40.41.6-0.7-1.3-0.8-0.3-0.5-0.3-0.4-0.3-0.4-0.3-0.2-0.4-0.7-0.6-0.70.8-0.3-0.9-0.60.2
Bone: final force4.06.411.3-3.3-2.8-3.4-2.9-2.9-2.7-3.1-2.7-2.9-3.1-2.6-2.4-2.4-2.5-2.4-2.2-1.8-0.1-0.70.0
Bone: final moment3.45.59.9-3.1-2.9-3.1-2.6-2.7-2.5-2.8-2.4-2.7-2.7-2.5-2.2-2.1-2.3-2.1-2.0-1.60.0-0.6-0.1
Food consumed during 24 hour testing period0.30.41.70.60.30.30.60.40.50.60.60.40.8-0.10.50.70.40.9-0.30.41.30.70.2
Glucose2.13.210.5-2.6-3.2-2.1-1.9-1.9-2.1-1.8-2.0-1.5-1.6-1.3-1.7-1.7-1.6-2.10.4-0.8-1.5-1.2-0.3
Heart weight3.96.012.4-3.5-3.4-3.0-2.7-2.8-2.6-2.6-2.6-2.9-2.6-3.2-2.3-2.2-2.2-1.7-2.4-1.50.30.2-0.8
Delay discount hyperbolic model param1.81.96.51.31.41.11.10.90.91.11.01.21.0-0.61.31.61.42.0-1.41.32.52.4-0.7
Intermittent access intake day 1-15 change0.20.42.90.60.60.50.60.40.40.40.40.60.51.40.2-0.00.30.11.70.1-0.8-0.60.7
Intermittent access intake escalation0.20.41.90.70.50.70.70.60.50.70.60.70.61.10.50.30.50.31.40.3-0.5-0.30.4
Intermittent access intake escalation 20.20.20.50.60.40.40.60.50.40.40.50.70.30.70.40.30.50.50.70.30.10.00.4
Intermitt. access day 1 inactive lever presses0.31.13.80.0-1.60.61.10.90.90.81.00.91.0-1.41.11.11.10.80.01.40.21.0-1.9
Intermitt. access day 15 inactive lever presses0.20.31.6-0.9-1.3-0.6-0.5-0.4-0.4-0.5-0.5-0.3-0.5-0.8-0.3-0.5-0.3-0.8-0.3-0.1-0.7-0.3-0.4
Intermitt. access escalation Index0.81.11.91.00.41.31.21.31.11.11.21.41.10.31.11.21.21.30.41.20.60.8-0.5
Intermittent access day 1 total infusions0.10.20.60.60.60.50.40.30.30.30.40.30.40.80.30.20.20.20.40.1-0.4-0.20.2
Intermittent access day 15 total infusions0.50.72.21.00.71.00.90.70.70.90.80.90.91.50.60.40.60.31.50.3-0.9-0.60.5
Intermittent access terminal intake (last 3 days)0.30.31.60.50.20.50.50.40.40.50.50.50.41.10.30.10.3-0.11.30.1-1.0-0.80.4
Intermittent access total infusions0.20.20.70.60.60.60.50.30.40.50.40.50.40.80.30.30.40.10.70.2-0.6-0.50.1
Intermittent access day 1 locomotion0.60.73.90.41.10.1-0.1-0.3-0.2-0.1-0.1-0.1-0.12.0-0.3-0.6-0.5-0.61.1-0.8-1.5-1.61.4
Intermittent access day 15 total locomotion0.20.42.8-0.4-0.8-0.1-0.2-0.3-0.3-0.3-0.2-0.2-0.20.2-0.3-0.6-0.2-1.00.5-0.3-1.7-1.3-0.2
Intermittent access total locomotion0.60.72.60.10.8-0.1-0.4-0.5-0.5-0.5-0.5-0.3-0.51.6-0.6-0.8-0.6-0.80.7-0.8-1.4-1.41.2
Intermittent access standard deviation0.20.43.3-0.0-0.60.20.30.10.20.30.20.20.10.60.0-0.30.1-0.71.60.0-1.8-1.1-0.1
Left kidney weight5.023.439.8-6.3-4.3-6.1-5.9-5.9-5.9-5.8-5.8-5.7-5.9-3.2-5.3-5.1-5.1-3.8-2.9-4.2-0.4-1.51.2
Right kidney weight5.726.044.0-6.6-4.6-6.6-6.2-6.3-6.3-6.1-6.2-5.9-6.0-2.6-5.6-5.5-5.5-3.9-2.2-4.6-0.6-1.91.7
Cocaine induced anxiety0.40.64.81.22.20.70.50.60.60.40.60.60.40.80.50.70.60.4-0.50.30.90.10.7
Post-drug Anxiety0.40.42.8-0.20.4-0.2-0.2-0.1-0.2-0.4-0.20.0-0.2-1.20.00.10.30.2-1.70.31.10.9-0.6
Baseline Anxiety0.70.85.0-1.3-2.2-0.7-0.3-0.3-0.4-0.5-0.4-0.1-0.3-1.9-0.1-0.2-0.0-0.1-0.60.50.00.8-1.5
Tail length0.00.21.0-0.5-1.0-0.0-0.2-0.1-0.3-0.4-0.20.1-0.3-0.5-0.1-0.1-0.1-0.30.30.3-0.6-0.2-0.9
Length with tail0.62.57.8-2.4-2.8-1.6-1.7-1.5-1.7-1.6-1.6-1.2-1.6-2.4-1.2-1.2-1.0-1.2-1.3-0.3-0.40.1-1.5
Length without tail1.34.315.7-3.3-4.0-2.2-2.1-1.9-2.1-1.9-2.1-1.6-1.8-3.5-1.5-1.5-1.4-1.5-1.9-0.3-0.40.2-1.9
Times rat made contact with spout0.20.20.6-0.6-0.6-0.8-0.6-0.4-0.6-0.6-0.6-0.3-0.7-0.3-0.4-0.5-0.5-0.1-0.2-0.20.30.00.2
Lifetime Intake0.20.20.80.70.90.70.50.40.50.50.50.50.50.70.40.30.40.20.50.2-0.3-0.30.1
Liver weight, left7.211.824.1-4.9-4.2-4.2-4.0-4.1-4.0-3.7-3.9-4.1-3.6-2.7-3.6-3.5-3.6-3.0-1.5-2.8-1.3-1.40.0
Liver weight, right4.06.912.4-3.5-2.4-3.5-3.2-3.4-3.3-3.2-3.3-2.9-3.0-0.9-2.9-2.9-3.0-1.8-0.7-2.3-0.5-1.21.1
Locomotor activity0.00.10.30.30.50.50.10.20.10.20.10.20.00.50.10.10.20.20.50.0-0.2-0.0-0.0
Locomotor testing distance0.20.42.60.91.60.60.20.20.10.10.10.2-0.21.50.10.10.10.40.7-0.3-0.0-0.10.8
Locomotor testing rearing0.30.62.6-0.00.6-0.2-0.3-0.3-0.6-0.5-0.5-0.3-0.71.6-0.5-0.6-0.5-0.51.3-0.8-1.1-1.01.1
Locomotion in novel chamber0.30.32.50.10.4-0.7-0.3-0.3-0.2-0.4-0.3-0.5-0.40.7-0.6-0.2-0.50.10.4-0.70.90.11.6
Locomotion in novel chamber post-restriction0.71.24.0-0.50.6-1.0-1.0-1.1-1.1-0.8-1.1-1.2-0.90.9-1.3-1.0-1.4-1.30.8-1.5-0.4-0.82.0
Fecal boli incidents, locomotor time 10.00.10.4-0.20.1-0.1-0.0-0.2-0.3-0.2-0.20.2-0.4-0.60.1-0.10.2-0.3-0.20.30.00.2-0.4
Change in fecal boli incidents, locomotor task0.50.42.3-0.8-0.6-0.7-0.8-0.7-0.5-0.4-0.6-0.9-0.4-0.9-0.5-0.4-0.50.0-1.5-0.50.70.2-0.1
Time >=10cm from walls, locomotor time 10.10.10.40.30.40.30.30.30.30.20.30.20.1-0.30.40.40.20.3-0.40.30.60.3-0.3
Bouts of movement, locomotor time 10.10.21.00.0-1.00.30.20.30.40.50.40.10.50.10.20.20.10.3-0.20.2-0.60.1-0.7
Total resting periods, locomotor time 10.10.10.5-0.1-0.70.20.00.10.20.30.2-0.10.30.2-0.00.0-0.00.3-0.2-0.0-0.50.1-0.4
Rest time, locomotor task time 10.50.71.4-0.70.3-0.9-1.1-1.0-1.0-1.0-1.0-1.0-1.20.0-0.9-0.8-0.9-0.3-0.7-0.90.4-0.10.8
Distance moved, locomotor task time 10.10.11.00.2-0.30.20.40.30.30.30.30.20.50.40.2-0.10.1-0.31.00.0-0.8-0.50.1
Vertical activity count, locomotor time 10.10.20.9-0.30.1-0.1-0.4-0.4-0.4-0.3-0.4-0.4-0.20.4-0.5-0.7-0.3-0.70.5-0.6-1.0-0.80.4
Time >=10cm from walls, locomotor time 20.60.93.4-1.2-0.2-1.0-1.0-1.2-1.1-1.1-1.0-0.9-1.1-1.4-0.7-0.7-0.6-0.6-1.8-0.50.60.1-0.2
Bouts of movement, locomotor time 20.91.53.11.60.41.31.31.41.61.51.31.31.51.71.01.10.81.01.80.8-0.4-0.00.4
Total resting periods, locomotor time 20.81.43.61.50.41.31.21.31.51.41.21.21.41.91.00.90.70.91.90.7-0.6-0.20.4
Rest time, locomotor task time 20.10.21.10.40.50.2-0.00.30.2-0.00.10.2-0.31.10.0-0.2-0.20.10.6-0.1-0.6-0.70.4
Distance moved, locomotor task time 20.10.20.6-0.5-0.1-0.5-0.3-0.6-0.4-0.2-0.4-0.6-0.0-0.8-0.3-0.2-0.2-0.3-0.5-0.30.50.20.0
Vertical activity count, locomotor time 20.20.20.8-0.50.0-0.3-0.6-0.6-0.6-0.3-0.5-0.5-0.3-0.8-0.4-0.3-0.1-0.2-0.9-0.30.40.3-0.2
Light reinforcement 10.20.41.0-0.11.0-0.3-0.6-0.7-0.6-0.5-0.6-0.9-0.40.6-0.7-0.4-0.7-0.1-0.1-1.00.3-0.41.0
Light reinforcement 20.30.42.60.91.60.90.20.40.50.70.3-0.10.80.70.10.50.10.70.3-0.20.80.10.4
Bone: marrow area0.40.93.8-1.6-2.0-1.4-0.9-1.0-0.9-0.8-0.9-0.8-0.8-1.2-0.8-0.8-0.8-0.7-0.5-0.3-0.30.0-0.3
Bone: maximum diameter1.52.713.4-2.5-3.7-1.9-1.5-1.5-1.4-1.7-1.4-1.5-1.5-2.4-1.2-1.2-1.1-1.5-0.8-0.5-0.70.1-1.2
Bone: maximum force2.64.68.3-2.8-2.3-2.9-2.4-2.4-2.3-2.6-2.3-2.4-2.4-2.5-2.0-1.9-2.0-1.8-2.4-1.40.5-0.2-0.1
Bone: maximum moment2.13.66.7-2.6-2.3-2.6-2.1-2.1-2.0-2.2-2.0-2.1-2.1-2.5-1.7-1.6-1.7-1.5-2.2-1.10.7-0.0-0.2
Mean time between licks in bursts1.43.46.01.3-0.21.72.02.01.91.91.92.32.0-0.72.12.12.12.3-0.32.41.61.9-1.7
Mean num. licks in bursts1.11.73.9-0.70.3-1.3-1.2-1.0-1.1-1.3-1.2-1.1-1.41.8-1.4-1.5-1.6-0.81.1-1.6-1.1-1.52.0
Cd content in liver0.50.53.21.11.80.20.30.40.20.60.30.30.50.70.30.30.10.4-0.2-0.11.50.41.3
Co content in liver0.40.51.5-0.30.7-0.8-0.8-0.7-0.8-0.5-0.9-0.7-0.40.0-0.8-0.7-0.7-0.5-0.4-0.80.7-0.41.2
Cu content in liver0.20.30.60.80.20.40.60.50.70.50.70.50.70.60.40.30.30.10.80.30.0-0.40.6
Fe content in liver0.81.05.4-0.6-1.50.1-0.00.20.20.10.10.10.3-2.30.40.40.60.3-1.60.90.91.6-2.0
K content in liver0.70.72.80.9-0.10.80.91.10.80.90.91.00.91.00.60.50.70.31.70.7-0.7-0.50.2
Mg content in liver1.01.07.20.60.00.30.50.60.40.60.50.50.61.90.1-0.10.1-0.32.7-0.1-1.5-1.71.1
Mn content in liver0.40.50.9-0.7-0.4-0.6-0.6-0.8-0.7-0.4-0.6-0.7-0.50.5-0.8-0.7-0.8-0.61.0-0.8-0.9-0.70.6
Na content in liver0.70.84.2-0.6-1.1-0.3-0.4-0.3-0.7-0.0-0.6-0.3-0.11.0-0.7-0.8-0.6-0.72.1-0.5-1.7-1.40.7
Rb content in liver0.30.41.50.4-0.20.50.60.50.60.80.70.80.70.40.50.30.3-0.01.20.6-0.9-0.5-0.1
Se content in liver0.50.61.30.70.50.90.70.80.71.10.70.61.1-0.60.80.71.10.7-0.50.70.81.0-0.7
Sr content in liver1.21.03.61.41.90.91.01.21.01.11.00.61.01.70.80.80.60.90.2-0.00.3-0.01.1
Zn content in liver0.91.06.00.91.30.40.30.40.20.50.20.40.42.5-0.1-0.2-0.1-0.12.0-0.4-0.9-1.21.8
Bone: minimum diameter2.44.48.8-2.9-3.0-2.5-2.5-2.4-2.3-2.4-2.3-2.4-1.9-2.3-2.1-1.9-2.0-2.1-1.3-1.4-0.7-0.6-0.6
Time in familiar zone, hab. session 12.82.84.2-1.7-1.0-1.9-1.9-1.8-1.7-1.7-1.8-1.9-1.70.5-2.0-1.9-2.1-1.80.9-1.9-1.5-1.41.3
Time in novel zone, hab. session 13.13.15.11.61.02.21.91.91.81.81.82.11.7-0.82.02.02.21.6-0.92.11.01.4-2.0
Total zone transitions, hab. session 11.72.33.7-1.5-0.4-1.6-1.9-1.9-1.7-1.8-1.9-1.6-1.60.0-1.8-1.7-1.7-1.80.1-1.6-1.2-1.60.9
Total locomotion distance, hab. session 10.30.52.10.1-0.20.30.20.20.30.30.20.30.6-1.50.50.60.50.3-1.20.71.11.0-1.0
Locomotion velocity, hab. session 10.20.31.60.0-0.10.10.10.00.20.20.10.10.5-1.30.30.50.30.4-1.10.51.21.0-0.8
Time in familiar zone, hab. session 20.70.72.50.2-0.80.80.70.70.60.60.70.50.7-0.80.80.90.81.10.10.90.61.5-1.6
Time in novel zone, hab. session 20.50.51.6-0.20.8-0.6-0.6-0.6-0.6-0.5-0.6-0.4-0.50.7-0.7-0.7-0.6-0.8-0.0-0.8-0.5-1.21.3
Total zone transitions, hab. session 20.40.51.0-0.4-0.3-0.8-0.7-0.7-0.5-0.7-0.6-0.6-0.50.8-0.8-0.8-0.9-0.70.9-0.8-0.7-0.81.0
Total locomotion distance, hab. session 20.30.40.6-0.8-0.7-0.8-0.7-0.8-0.7-0.7-0.7-0.7-0.5-0.5-0.7-0.5-0.7-0.4-0.3-0.50.20.20.1
Locomotion velocity, hab. session 20.30.50.8-0.9-0.8-0.9-0.8-0.9-0.8-0.8-0.8-0.8-0.6-0.3-0.8-0.7-0.9-0.5-0.0-0.6-0.1-0.10.3
Novel to familiar place preference ratio1.11.14.00.50.41.00.80.91.01.10.90.60.9-1.41.01.11.00.9-2.00.91.11.4-1.4
Novelty place preference0.91.02.90.60.61.10.80.91.01.20.90.51.0-1.21.01.01.00.8-1.70.80.91.3-1.3
Time in novel zone, NPP test1.01.13.80.30.21.00.60.70.81.00.80.40.8-1.60.91.01.00.8-2.00.80.91.5-1.7
Total zone transitions, NPP test0.40.61.3-0.9-0.3-1.1-0.9-1.1-0.9-1.1-0.9-0.8-1.10.2-0.9-0.8-0.9-0.30.0-0.80.1-0.50.8
Total locomotion distance, NPP test0.20.31.9-0.50.0-0.5-0.3-0.6-0.5-0.4-0.4-0.5-0.3-0.9-0.3-0.1-0.30.1-1.4-0.21.10.60.0
Locomotion velocity, NPP test0.20.31.8-0.20.5-0.5-0.2-0.5-0.4-0.3-0.3-0.3-0.2-0.5-0.2-0.0-0.20.3-1.2-0.21.30.50.4
Intraocular pressure0.40.63.7-0.3-1.20.30.20.10.50.40.4-0.20.1-1.90.40.30.4-0.1-1.10.50.00.5-1.8
Delta distance traveled before/after self-admin0.10.10.9-0.3-0.3-0.0-0.0-0.1-0.2-0.2-0.20.0-0.10.4-0.1-0.2-0.2-0.20.9-0.0-0.9-0.4-0.0
Delta ambulatory time before/after self-admin0.10.10.7-0.5-0.7-0.1-0.1-0.1-0.2-0.2-0.2-0.1-0.10.1-0.2-0.1-0.3-0.30.60.0-0.9-0.3-0.3
Parametrial fat weight10.023.567.0-7.3-8.2-6.0-5.5-5.5-5.2-5.2-5.2-5.2-5.4-5.1-4.4-4.6-4.3-3.4-2.7-2.9-1.3-0.6-1.6
Pavlov. Cond. lever latency1.11.42.41.10.21.51.31.51.41.51.31.51.40.01.31.31.40.90.21.30.10.6-0.9
Pavlov. Cond. magazine entry latency0.20.30.7-0.5-0.8-0.7-0.5-0.5-0.4-0.6-0.4-0.8-0.50.0-0.6-0.5-0.7-0.20.2-0.60.20.00.4
Pavlov. Cond. change in total contacts1.41.42.3-1.4-1.2-1.4-1.3-1.4-1.4-1.5-1.3-1.5-1.3-0.0-1.4-1.4-1.5-0.90.5-1.3-0.5-0.70.5
Pavlov. Cond. index score0.81.01.8-1.1-0.9-1.3-1.1-1.2-1.1-1.3-1.0-1.3-1.10.0-1.2-1.1-1.2-0.70.2-1.1-0.2-0.40.6
Pavlov. Cond. latency score0.70.81.5-0.9-0.7-1.2-1.1-1.1-1.0-1.2-1.0-1.2-1.00.1-1.1-1.0-1.2-0.60.2-1.0-0.1-0.40.6
Pavlov. Cond. lever contacts1.01.22.3-1.2-0.9-1.5-1.2-1.3-1.2-1.4-1.1-1.3-1.2-0.0-1.3-1.3-1.4-1.00.3-1.2-0.5-0.80.8
Pavlov. Cond. magazine entry number0.40.41.10.71.11.00.60.70.60.90.50.80.8-0.30.70.70.80.4-0.50.70.20.2-0.5
Pavlov. Cond. intertrial magazine entries1.92.24.8-1.8-0.5-1.9-1.8-1.9-1.8-1.9-1.8-1.6-1.9-1.6-1.4-1.4-1.2-0.8-2.2-1.10.7-0.00.1
Pavlov. Cond. lever-magazine prob. diff.0.81.01.8-1.1-1.0-1.3-1.1-1.2-1.1-1.3-1.0-1.3-1.1-0.1-1.2-1.1-1.2-0.60.2-1.1-0.2-0.30.5
Pavlov. Cond. response bias0.50.61.4-0.7-0.8-1.2-0.7-0.9-0.8-1.1-0.7-0.9-1.00.3-0.8-0.9-1.0-0.60.5-0.9-0.2-0.40.8
Pavlov. Cond. lever latency0.30.42.50.31.6-0.1-0.2-0.3-0.3-0.4-0.3-0.4-0.41.3-0.4-0.5-0.4-0.20.2-0.9-0.2-0.81.3
Pavlov. Cond. magazine entry latency0.40.51.10.3-1.00.60.80.70.80.80.80.91.0-0.10.70.60.70.70.90.9-0.00.6-0.8
Pavlov. Cond. change in total contacts0.30.41.20.1-1.00.50.60.60.60.70.70.60.8-0.80.70.60.60.40.30.90.10.5-1.1
Pavlov. Cond. index score0.20.32.0-0.2-1.40.20.30.30.40.40.40.40.5-0.90.40.40.40.20.30.70.00.6-1.1
Pavlov. Cond. latency score0.30.41.8-0.1-1.30.20.40.40.50.50.40.50.6-0.80.50.50.50.40.30.80.10.7-1.0
Pavlov. Cond. lever contacts0.20.21.8-0.5-1.3-0.2-0.2-0.1-0.1-0.0-0.1-0.0-0.0-1.1-0.00.1-0.0-0.3-0.20.40.00.4-0.9
Pavlov. Cond. magazine entry number0.20.21.10.01.0-0.1-0.4-0.3-0.4-0.5-0.4-0.4-0.70.2-0.4-0.2-0.2-0.1-0.7-0.50.3-0.20.5
Pavlov. Cond. intertrial magazine entries1.52.33.8-1.9-1.1-1.8-1.8-1.9-1.8-1.6-1.8-1.9-1.9-0.8-1.7-1.5-1.6-1.4-1.0-1.5-0.4-0.60.4
Pavlov. Cond. lever-magazine prob. diff.0.20.21.6-0.2-1.30.10.30.20.30.30.30.40.5-0.70.40.30.30.10.40.7-0.10.4-0.9
Pavlov. Cond. response bias0.40.52.1-0.1-1.40.30.40.40.50.50.40.50.6-1.20.60.60.50.3-0.10.90.30.8-1.4
Time in closed arm before self-admin0.40.51.0-0.6-0.3-0.6-0.7-0.9-0.7-0.6-0.7-0.8-0.40.5-0.8-1.0-1.0-0.61.0-0.9-0.8-0.70.5
Time in closed arm after self-admin0.40.42.90.50.9-0.0-0.1-0.20.10.10.1-0.30.11.7-0.3-0.5-0.50.20.7-0.9-0.3-0.21.4
Time in open arm before self-admin1.31.43.31.81.81.51.31.31.31.21.31.01.20.21.31.61.40.7-0.60.90.80.4-0.4
Time in open arm after self-admin1.61.83.61.00.01.41.51.41.31.21.31.61.3-1.01.61.81.71.10.01.90.71.1-1.9
Bone: periosteal estimation2.55.311.3-3.3-3.4-3.1-2.6-2.7-2.5-2.5-2.5-2.5-2.4-2.7-2.2-2.0-2.1-2.0-1.8-1.4-0.2-0.1-0.4
Bone: periosteal perimeter4.17.016.5-3.7-4.1-3.3-2.9-2.9-2.9-3.0-2.9-2.7-2.9-2.1-2.6-2.6-2.5-2.8-0.7-1.8-1.6-1.1-0.2
Bone: post-yield work0.71.15.7-0.7-0.9-0.5-0.1-0.2-0.1-0.2-0.1-0.10.2-2.40.20.40.40.6-2.30.71.91.5-1.3
Progressive ratio test 1 active lever presses0.70.83.01.21.00.90.90.70.81.00.80.80.91.70.60.40.40.41.70.1-0.7-0.40.8
Progressive ratio test 1 breakpoint0.60.82.81.11.00.90.90.60.81.00.80.80.81.70.60.40.40.41.60.1-0.6-0.40.8
Progressive ratio test 1 inactive lever presses0.10.20.40.4-0.10.50.60.50.60.40.50.50.6-0.10.60.50.40.20.50.5-0.30.3-0.6
Progressive ratio test 2 active lever presses0.40.52.1-0.3-0.1-0.3-0.3-0.5-0.4-0.5-0.4-0.4-0.40.8-0.6-0.7-0.5-0.91.2-0.6-1.4-1.30.5
Progressive ratio test 2 breakpoint0.40.42.0-0.2-0.2-0.2-0.3-0.5-0.3-0.5-0.3-0.3-0.40.7-0.5-0.6-0.5-0.91.2-0.5-1.4-1.30.4
Progressive ratio test 2 inactive lever presses0.10.20.70.2-0.20.30.40.20.30.10.30.40.3-0.80.50.60.60.2-0.40.60.40.4-0.8
Incentive Sensitization - Responses0.70.92.5-1.0-0.9-0.8-0.8-0.9-0.9-1.2-0.9-0.8-1.00.0-0.9-1.0-0.8-1.30.7-0.7-1.6-1.50.1
Incentive Sensitization - Breakpoint0.60.82.5-0.9-0.9-0.7-0.7-0.8-0.8-1.1-0.8-0.8-0.9-0.0-0.9-0.9-0.7-1.30.6-0.6-1.6-1.5-0.1
Sum of active levers in priming session hrs 5-60.40.41.50.2-0.70.60.70.40.40.60.50.60.60.20.60.50.50.61.20.7-0.50.2-0.7
Progressive ratio2.03.15.72.21.52.22.12.01.92.31.92.12.40.42.12.21.91.00.61.70.81.0-0.5
Food seeking constrained by brief footshock1.41.73.61.71.51.91.41.61.51.81.41.31.90.61.31.41.20.50.71.0-0.00.9-0.5
Seeking ratio, punishment vs. effort1.01.42.5-1.0-0.1-1.1-1.3-1.1-1.1-1.4-1.2-1.4-1.40.8-1.5-1.6-1.4-0.90.7-1.5-1.2-1.00.8
Retroperitoneal fat weight14.260.4141.5-11.5-11.9-9.4-9.1-8.7-8.5-8.2-8.6-9.1-8.3-8.3-7.6-7.3-7.1-5.8-4.8-5.4-1.7-0.8-2.2
Reaction time number correct0.20.32.50.2-0.90.10.40.20.50.50.40.20.30.90.20.00.0-0.21.6-0.0-1.2-0.30.2
Reaction time mean minus median0.51.14.3-1.0-0.6-1.0-0.7-0.8-0.8-1.1-0.7-0.5-0.90.8-0.9-1.2-1.0-1.31.4-0.8-2.1-1.70.6
Reaction time mean minus median AUC1.02.69.3-0.8-0.3-1.0-0.7-0.9-0.9-1.0-0.8-0.6-1.02.3-1.2-1.6-1.5-1.63.0-1.4-2.9-2.81.8
Reaction time num false alarms0.71.02.5-1.00.2-1.3-1.3-1.3-1.1-1.6-1.2-1.1-1.3-0.2-1.1-1.0-1.1-0.6-0.8-1.00.4-0.20.8
Reaction time num false alarms AUC0.81.22.6-1.00.1-1.4-1.4-1.3-1.2-1.6-1.3-1.1-1.50.1-1.3-1.2-1.3-0.8-0.3-1.10.1-0.61.1
Reaction time trials correct on left0.20.32.50.2-0.90.10.40.20.50.50.40.20.30.90.20.00.0-0.21.6-0.0-1.2-0.30.2
Reaction time trials on left0.20.42.80.2-0.90.10.40.20.50.50.40.20.30.90.20.00.0-0.21.7-0.0-1.3-0.30.2
Reaction time mean0.81.37.80.30.20.10.30.20.10.10.20.40.02.3-0.1-0.5-0.3-0.82.8-0.4-2.5-1.91.1
Reaction time mean AUC1.01.610.10.40.20.10.40.20.10.00.20.40.02.6-0.1-0.6-0.4-0.93.2-0.5-2.7-2.11.3
Median of all reaction times1.01.59.20.70.50.40.60.40.30.40.40.60.32.60.1-0.3-0.1-0.53.0-0.3-2.3-1.91.3
Reaction time omissions0.20.42.5-0.5-1.2-0.0-0.10.1-0.1-0.1-0.10.0-0.10.5-0.2-0.3-0.2-0.21.5-0.0-1.6-0.4-0.5
Reaction time false alarm rate0.81.12.5-1.00.3-1.3-1.4-1.2-1.3-1.6-1.3-1.0-1.4-0.7-1.1-0.9-1.0-0.5-1.5-0.80.9-0.00.6
Reaction time premature initiation rate0.91.22.3-1.00.0-1.1-1.4-1.3-1.5-1.4-1.5-1.1-1.50.0-1.3-1.2-1.2-1.0-0.5-1.0-0.3-0.80.7
Reaction time premature initiations0.50.91.5-0.8-0.5-0.9-1.1-1.0-1.1-1.0-1.1-0.9-1.20.5-1.1-1.2-1.1-1.00.5-1.0-1.0-0.80.8
Std. dev. reaction times0.71.35.4-1.0-1.1-1.0-0.8-0.8-0.8-1.0-0.8-0.7-0.90.9-0.9-1.3-1.1-1.41.7-1.0-2.3-1.60.7
Reaction time trials completed0.20.42.80.2-0.90.10.40.20.50.50.40.20.30.90.20.00.0-0.21.7-0.0-1.3-0.30.2
Reaction time trials AUC0.20.32.30.1-1.0-0.00.30.10.40.30.30.00.20.80.1-0.1-0.1-0.31.5-0.2-1.2-0.30.2
Run reversals in cocaine runway, females0.10.10.40.0-0.20.40.10.20.20.30.20.20.3-0.20.20.10.1-0.20.10.3-0.6-0.3-0.6
Run reversals in cocaine runway, males0.20.21.00.21.0-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.11.0-0.4-0.5-0.4-0.30.6-0.6-0.5-0.40.9
Latency to leave start box in cocaine runway1.72.06.91.50.41.61.71.31.51.81.51.51.81.61.21.11.00.62.61.0-1.10.1-0.1
Latency to leave start box in cocaine runway, F0.70.82.50.9-0.11.01.10.91.01.40.90.81.60.70.80.80.80.51.40.7-0.50.6-0.3
Latency to leave start box in cocaine runway, M0.60.64.70.50.40.60.70.40.50.50.50.60.41.30.30.00.0-0.22.20.1-1.2-0.80.5
Std. dev. time between licks in bursts2.02.74.41.40.81.51.71.61.51.71.51.81.7-0.81.72.01.91.9-1.21.92.12.0-1.2
Total sessions with >9 infusions0.10.10.90.31.00.30.0-0.2-0.10.0-0.0-0.00.00.4-0.0-0.1-0.1-0.40.2-0.2-0.3-0.80.4
Short access day 1 total inactive lever presses1.11.42.60.90.21.21.11.01.11.21.10.91.3-1.11.41.41.41.1-0.91.31.41.6-1.4
Short access day 10 total inactive lever presses0.30.71.6-1.2-1.3-1.0-1.0-1.0-1.0-0.9-1.1-1.0-0.8-0.7-0.8-1.0-0.7-0.5-0.2-0.7-0.2-0.1-0.1
Short access day 1 total infusions0.10.10.50.20.70.30.0-0.3-0.10.1-0.0-0.10.00.5-0.1-0.2-0.10.00.2-0.3-0.3-0.40.2
Short access day 10 total infusions0.91.24.61.72.11.31.10.91.01.01.11.01.01.90.80.80.60.80.90.20.0-0.30.8
Short access total infusions0.40.52.71.11.60.90.70.50.70.70.70.60.71.10.50.50.50.50.40.10.2-0.20.5
Short access day 1 locomotion0.30.41.7-0.00.10.10.1-0.1-0.00.00.00.1-0.01.1-0.2-0.3-0.3-0.41.3-0.3-1.3-1.30.6
Short access day 10 total locomotion0.30.62.60.10.6-0.2-0.3-0.5-0.4-0.5-0.3-0.1-0.51.6-0.5-0.8-0.6-0.50.9-0.7-1.3-1.41.2
Short access total locomotion0.70.84.20.61.60.20.0-0.3-0.2-0.1-0.10.1-0.12.0-0.3-0.5-0.5-0.51.2-0.7-1.1-1.81.6
One hour access (0.3 mA shock)0.80.91.60.8-0.31.31.11.11.10.91.11.21.0-0.01.11.11.20.50.51.2-0.30.4-1.1
Compulsive drug intake0.30.41.7-0.5-1.3-0.1-0.10.20.1-0.10.1-0.00.1-1.20.30.00.30.3-1.00.40.30.9-1.2
One hour access (shock baseline)0.60.91.71.31.11.21.20.91.01.01.01.21.01.10.90.90.80.61.30.8-0.1-0.20.2
Social response proportion2.02.23.4-1.6-0.2-1.6-1.8-1.8-1.9-1.7-1.8-1.8-1.70.3-1.8-1.8-1.7-1.20.0-1.8-0.8-1.11.0
Social responses1.92.54.8-2.2-2.0-1.9-1.8-1.7-1.8-2.0-1.8-1.7-2.0-1.5-1.5-1.6-1.4-1.5-0.9-1.1-0.6-0.5-0.3
Social time0.81.04.5-0.4-0.5-0.6-0.4-0.6-0.7-0.5-0.5-0.5-0.51.5-0.8-1.1-1.0-0.72.1-1.0-1.6-1.81.1
Soleus weight4.312.716.8-3.9-2.7-4.0-3.8-3.7-3.7-3.8-3.7-3.6-3.91.6-3.9-4.1-4.0-3.32.5-3.7-3.9-3.92.5
Bone: stiffness1.11.95.8-1.8-1.4-1.7-1.4-1.3-1.2-1.5-1.2-1.4-1.4-2.3-1.0-0.9-1.0-0.9-2.4-0.60.80.5-0.5
Tibialis anterior weight0.51.75.7-1.7-1.6-1.0-1.4-1.3-1.1-1.2-1.2-1.0-1.20.3-1.3-1.4-1.3-1.31.4-1.0-2.4-1.5-0.2
Time to tail flick, vehicle, before self-admin0.20.21.6-0.3-0.3-0.2-0.3-0.4-0.3-0.2-0.3-0.4-0.2-1.2-0.10.2-0.1-0.2-1.30.10.80.1-0.5
Time to tail flick, vehicle, after self-admin0.10.10.5-0.5-0.3-0.3-0.5-0.4-0.3-0.3-0.4-0.4-0.3-0.7-0.3-0.3-0.3-0.4-0.4-0.20.00.5-0.4
Time to tail flick, test, before self-admin1.21.34.30.21.3-0.6-0.5-0.5-0.6-0.7-0.5-0.3-0.72.1-0.9-0.8-1.0-0.92.0-1.0-1.1-1.82.1
Time to tail flick, test, after self-admin1.51.62.41.0-0.01.21.31.21.31.31.31.21.4-0.71.51.41.51.6-0.91.41.31.5-1.4
Delta time to tail flick, vehicle, before/after SA0.20.21.3-0.6-1.2-0.4-0.2-0.1-0.1-0.2-0.2-0.2-0.3-0.3-0.2-0.4-0.2-0.60.6-0.1-1.00.3-0.4
Delta time to tail flick, test, before/after SA2.02.04.70.6-0.61.01.11.01.11.21.10.91.2-1.61.51.31.61.9-2.01.42.02.2-1.9
Tibia length0.41.12.0-1.2-0.6-1.2-1.4-1.0-1.4-1.1-1.4-1.1-1.3-0.8-1.2-1.0-1.0-1.1-0.9-0.8-0.1-0.40.2
Ambulatory time before self-admin0.60.94.70.92.20.2-0.10.1-0.1-0.1-0.1-0.1-0.22.2-0.4-0.4-0.4-0.21.4-0.8-0.4-1.21.8
Ambulatory time after self-admin0.80.94.90.71.50.40.00.2-0.1-0.20.00.1-0.12.1-0.3-0.2-0.4-0.32.2-0.6-1.1-1.41.2
Bone: tissue strength0.70.71.30.90.21.11.01.01.01.21.01.01.1-0.10.90.90.90.70.31.00.40.3-0.6
Total heroin consumption1.72.07.7-2.2-2.8-1.7-1.3-1.3-1.4-1.4-1.3-1.3-1.3-1.2-1.2-1.4-1.2-1.60.1-0.7-1.5-0.8-0.3
Bone: trabecular number0.81.46.9-1.8-2.2-1.1-0.9-0.6-1.0-0.8-0.9-0.7-0.7-2.6-0.5-0.4-0.3-0.4-1.90.20.50.5-1.6
Bone: trabecular spacing2.12.85.72.41.82.21.81.92.01.61.91.91.71.41.71.71.81.70.61.40.61.2-0.3
Bone: trabecular thickness4.35.313.6-3.4-3.7-2.8-2.6-2.4-2.5-2.4-2.5-2.4-2.5-2.5-2.2-2.2-2.0-2.2-1.1-1.3-1.0-0.8-0.6
Bone: trabecular tissue density1.01.56.51.71.71.31.11.01.11.11.11.20.92.60.70.70.61.12.00.4-0.10.11.0
Water consumed over 24 hours0.10.10.6-0.20.3-0.5-0.3-0.2-0.4-0.4-0.3-0.2-0.20.5-0.3-0.4-0.4-0.10.2-0.4-0.1-0.50.8
Number of responses in last shaping day0.10.10.40.20.40.2-0.0-0.1-0.10.3-0.10.00.10.6-0.1-0.1-0.1-0.30.7-0.2-0.5-0.40.5