Nrap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Nrap	0.04	0.03	9.4e-04	0.03	0.03	0.01	0.03	1.1e-03	1.6e-03	1.7e-02	2.0e-03
2	IL	alternative TSS	XM_008760535.4	0.12	0.08	8.5e-03	0.07	0.1	0.06	0.07	7.9e-03	2.1e-03	1.4e-02	7.5e-03
3	pVTA	intron excision ratio	chr1_265376925_265377983	0.03	0.03	5.5e-03	0	0.01	0.01	0.01	1.2e-01	2.0e-02	2.7e-02	1.1e-01
4	NAcc	alternative TSS	XM_008760535.4	0.02	0.01	1.8e-03	0.02	0.02	0.02	0.02	5.1e-04	7.1e-04	4.2e-04	8.0e-04
5	Adipose	gene expression	Nrap	0.04	0.03	7.9e-05	0.03	0.03	0.03	0.02	1.9e-04	7.1e-04	3.0e-04	1.1e-03
6	NAcc	intron excision ratio	chr1_265356294_265356972	0.13	0.07	2.5e-03	0	0.01	0.02	0	2.2e-01	4.0e-03	1.5e-03	1.7e-01
7	NAcc	gene expression	Nrap	0.08	0.07	5.5e-03	0	0.01	0	0	3.3e-01	6.1e-03	6.4e-02	1.5e-01
8	IC	isoform ratio	XM_039110113.2	0.06	0.05	9.0e-03	0.08	0.04	0.05	0.06	3.1e-04	7.0e-03	4.1e-03	1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.5	2.7	6.5	-1.9	-1.7	-1.7	2.6	1.3	0.6	-1.9	-0.0
Area under the delay curve	0.4	0.5	1.2	-1.0	-0.7	-0.4	1.1	0.8	-0.4	-0.2	-0.0
BMI with tail	8.3	28.5	49.8	-6.9	-6.8	-7.1	5.1	5.1	-1.5	-4.4	3.3
BMI without tail	5.2	15.9	28.1	-5.1	-5.2	-5.3	3.5	3.9	-1.5	-2.7	2.8
Body weight	9.2	40.3	72.0	-8.5	-7.8	-8.1	6.4	6.2	-1.6	-5.6	3.2
Weight adjusted by age	5.1	7.7	10.8	-2.8	-3.3	-3.1	1.7	3.2	-2.7	-2.0	2.9
Bone surface	0.6	1.2	2.6	-1.4	-1.2	-1.3	1.6	0.6	0.6	-1.1	0.0
Bone volume	2.2	3.9	6.7	-2.6	-2.3	-2.4	2.6	1.7	-0.0	-2.0	0.6
Breakpoint value in progressive ratio session	0.4	0.4	1.5	-0.8	-0.4	-0.1	1.0	0.1	-1.2	0.3	-0.4
Number of licking bursts	0.3	0.4	1.7	-0.8	-0.6	-0.5	1.3	-0.2	0.0	-0.5	-0.7
Context. condit. distance diff. score	0.8	1.0	1.5	0.6	1.0	0.6	-1.2	-1.2	1.2	0.8	-1.0
Locomotion velocity, session 1	0.6	0.7	1.9	1.4	0.8	1.2	-0.7	-0.2	-0.7	0.6	0.4
Locomotion distance, session 1	0.5	0.7	2.0	0.6	-0.1	0.1	-1.1	0.3	-1.1	0.6	1.4
Locomotion velocity, session 2	0.6	0.7	2.6	0.2	0.1	-0.0	-1.6	-0.1	-0.6	0.8	1.3
Locomotion distance, session 2	1.8	2.5	8.8	-1.0	-1.6	-1.2	-0.3	1.0	-3.0	0.9	2.0
Locomotion velocity, session 3	0.7	0.8	2.4	-0.2	-0.3	-0.2	-1.0	0.5	-1.6	0.6	1.4
Locomotion distance, session 3	0.9	1.0	2.4	-0.3	-0.4	-0.5	-1.4	0.3	-1.4	0.8	1.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	0.0	-0.2	-0.1	0.4	0.7	-0.2	-0.4	0.3
Stereotopy head waving duration, day 3	0.4	0.4	0.8	0.7	0.6	0.7	0.5	0.4	0.8	-0.9	-0.4
Locomotion velocity, session 7	0.2	0.2	0.5	-0.7	-0.5	-0.5	0.4	0.3	0.2	-0.5	0.4
Locomotion distance, session 7	0.1	0.2	0.8	-0.0	0.2	-0.0	-0.4	-0.6	0.9	0.3	0.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.2	-0.3	-0.1	-0.1	0.0	0.1	-0.5	0.1	-0.1
Stereotopy head waving duration, day 7	0.5	0.6	1.1	-0.8	-0.8	-0.7	0.9	1.1	-0.4	-0.9	0.3
Locomotion velocity, session 8	1.7	2.0	2.7	1.6	1.7	1.4	-1.5	-1.6	1.0	1.2	-1.3
Locomotion distance, session 8	0.7	1.0	3.2	0.6	0.6	0.4	-1.8	-1.1	-0.4	1.7	-0.0
Degree of sensitization distance	1.5	1.5	4.2	0.6	1.0	0.9	0.7	-1.2	2.0	0.1	-2.1
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.3	-0.0	-0.3	-0.0	-0.2
Conditioned locomotion	0.1	0.1	0.2	0.4	0.3	0.3	-0.5	-0.1	-0.0	0.4	0.2
Cocaine response after cond. corrected	2.5	3.0	6.3	1.9	1.3	1.4	-2.5	-1.3	-1.6	2.4	0.2
Cocaine response after cond. not corrected	2.5	3.0	5.6	2.2	1.7	1.8	-2.4	-1.6	-0.6	2.1	-0.3
Cocaine response before conditioning	1.0	1.2	5.5	0.2	0.7	0.5	0.7	-0.5	2.4	-1.0	-1.4
Saline control response	0.4	0.5	1.3	1.0	0.6	0.8	-1.1	-0.2	-0.4	0.7	0.3
Bone: connectivity density	0.4	0.6	2.4	-0.1	0.1	-0.1	0.9	-0.2	1.5	-0.9	-0.7
Bone: cortical apparent density	1.1	1.5	6.8	0.9	0.7	0.5	-2.6	-0.3	-0.8	1.3	1.3
Bone: cortical area	8.3	12.7	19.7	-4.4	-4.4	-4.2	3.7	3.8	-1.4	-3.0	2.4
Bone: cortical porosity	0.1	0.1	0.3	-0.2	0.1	0.2	0.3	-0.2	-0.1	0.5	-0.4
Bone: cortical porosity	0.3	0.3	1.1	-0.8	-0.4	-0.3	1.0	0.0	0.1	-0.0	-0.5
Bone: cortical thickness	4.5	7.5	11.9	-3.5	-3.3	-3.2	2.2	3.1	-1.4	-2.1	2.4
Bone: cortical thickness	2.4	2.8	5.2	-2.2	-2.1	-2.3	0.9	1.6	-0.8	-1.0	1.7
Bone: cortical tissue density	1.3	1.7	7.3	1.1	0.9	0.7	-2.7	-0.5	-0.7	1.4	1.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.7	0.4	-0.0	0.2	-0.5	0.1	-0.8	0.4	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.5	0.2	0.4	-0.3	-0.1	-0.1	-0.0	0.0
Condit. Reinf. active responses	0.5	0.6	1.3	-0.3	-0.9	-0.5	0.6	0.9	-0.9	-0.5	1.1
Condit. Reinf. inactive responses	1.0	1.3	2.2	-0.7	-1.2	-0.9	1.4	1.5	-0.6	-1.1	1.3
Incentive salience index mean	0.5	0.6	1.3	0.8	0.3	0.6	-0.9	-0.3	-1.1	0.9	0.7
Condit. Reinf. lever presses	0.3	0.5	1.0	0.7	0.3	0.7	-0.7	-0.3	-1.0	0.7	0.8
Condit. Reinf. active minus inactive responses	1.4	1.8	6.2	-0.4	-0.9	-0.4	2.5	1.6	0.3	-2.1	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	2.1	0.3	-0.1	0.2	1.4	0.3	0.3	-0.8	0.1
Condit. Reinf. active responses	2.6	3.6	9.1	-1.4	-1.6	-1.1	3.0	2.4	0.2	-2.8	0.6
Condit. Reinf. inactive responses	1.6	2.0	4.7	-1.4	-1.2	-0.9	1.8	2.0	0.4	-2.2	0.2
Condit. Reinf. lever presses	0.6	0.9	2.0	-1.1	-1.0	-0.6	1.4	1.1	-0.9	-0.8	0.2
Condit. Reinf. lever reinforcers received	1.8	2.5	6.5	-1.1	-1.4	-0.8	2.5	2.1	-0.2	-2.3	0.5
Conditioned reinforcement - actives	2.0	3.4	20.7	-0.0	-0.3	0.5	-1.1	0.4	-4.5	1.7	1.2
Conditioned reinforcement - inactives	0.9	1.4	6.7	-1.0	-0.9	-0.4	0.4	1.3	-2.6	-0.2	0.7
Conditioned locomotion	2.3	2.9	13.9	-0.1	-0.5	0.0	-1.5	0.3	-3.7	1.9	1.9
Patch foraging indifference point 0 sec	2.4	4.4	6.4	-2.3	-2.5	-2.5	2.3	2.3	-0.6	-2.1	1.4
Patch foraging indifference point AUC	0.2	0.3	1.2	-0.0	-0.1	0.4	0.9	0.1	-1.1	0.3	-0.5
Delay disc. indifference point, 0s delay	0.6	0.7	1.9	-1.1	-0.9	-0.8	0.3	0.8	-1.4	0.3	0.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.8	-0.4	-0.1	0.2	0.9	0.1	0.1	0.2	-0.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.8	-0.2	0.3	0.2	-0.5	-0.3	-0.4	0.9	-0.6
Delay disc. indifference point, 24s delay	0.6	0.7	2.6	-0.8	-0.4	-0.1	1.6	0.3	0.9	-0.6	-0.9
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.0	0.2	0.3	-0.1	-0.2	-0.3	0.5	-0.6
Delay disc. indifference point, 8s delay	3.0	3.5	6.0	-2.0	-2.1	-1.5	2.1	2.5	-1.6	-1.3	1.6
Indifference point function ln k	0.3	0.5	2.5	0.2	0.1	-0.3	-0.2	0.0	1.6	-0.8	0.5
Indifference point function log k	0.3	0.5	2.5	0.2	0.1	-0.3	-0.2	0.0	1.6	-0.8	0.5
Patch foraging total patch changes 0 sec	2.3	4.3	6.1	-2.3	-2.5	-2.4	2.4	2.3	-0.5	-2.1	1.3
Patch foraging total patch changes 12 sec	0.6	0.8	2.3	-1.0	-1.0	-0.8	1.5	0.9	-0.7	-0.7	-0.1
Patch foraging total patch changes 18 sec	1.7	2.6	7.1	-1.5	-1.8	-1.3	2.7	1.7	-1.3	-1.3	0.4
Patch foraging total patch changes 24 sec	0.9	1.6	4.4	-1.4	-1.3	-0.8	2.1	1.4	-1.2	-0.9	0.2
Patch foraging total patch changes 6 sec	3.7	5.6	8.0	-2.6	-2.8	-2.5	2.8	2.8	-1.6	-2.1	1.3
Patch foraging time to switch 0 sec	0.3	0.6	1.6	0.5	0.9	0.8	-1.3	-0.8	-0.2	1.1	-0.4
Patch foraging water rate 0 sec	0.5	1.0	2.1	-0.5	-1.0	-1.0	1.2	1.2	0.5	-1.4	0.7
Patch foraging water rate 12 sec	1.2	2.6	5.7	-1.1	-1.0	-1.2	2.2	1.2	2.2	-2.4	0.1
Patch foraging water rate 18 sec	0.5	0.8	1.5	-1.0	-1.1	-1.1	0.2	0.9	-0.7	-0.4	1.2
Patch foraging water rate 24 sec	1.2	1.7	3.0	-1.2	-1.7	-1.7	0.7	1.2	-1.6	-0.1	1.4
Patch foraging water rate 6 sec	0.4	0.6	1.2	-0.6	-0.9	-1.1	0.4	1.0	-0.0	-0.4	1.0
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	2.4	0.4	0.4	0.4	-1.1	-1.0	-1.4	1.6	0.1
Distance traveled before self-admin	0.7	0.9	4.8	0.8	0.5	0.0	-2.2	-0.5	-0.2	0.8	0.9
Distance traveled after self-admin	1.2	1.5	3.5	-0.3	-0.4	-0.5	-1.9	-0.8	-1.5	1.7	1.3
Extensor digitorum longus weight	0.3	1.2	3.0	-1.2	-0.9	-1.0	1.7	0.5	1.0	-1.4	0.1
Bone: elastic displacement	0.0	0.0	0.1	-0.0	0.1	0.1	0.1	-0.3	0.2	0.1	-0.3
Bone: elastic work	1.1	1.5	2.7	-1.5	-1.5	-1.6	-0.0	0.9	-1.2	-0.1	1.5
Bone: endosteal estimation	1.3	2.8	4.6	-2.1	-2.1	-2.1	2.1	1.4	-0.9	-1.0	0.5
Bone: endosteal perimeter	4.3	9.1	14.1	-3.6	-3.8	-3.7	2.9	3.1	-1.5	-2.4	2.4
Epididymis fat weight	10.2	35.0	55.4	-7.4	-6.7	-6.8	7.1	5.9	0.3	-6.5	2.2
Delta time in closed arm before/after self-admin	0.3	0.2	0.7	-0.0	-0.1	-0.1	-0.8	0.4	-0.7	0.6	0.4
Delta time in open arm before/after self-admin	0.5	0.5	2.2	-0.5	-0.6	-0.5	1.5	-0.2	0.3	-0.8	0.1
Diff in mean of infusions in LGA sessions	1.1	1.4	2.1	1.3	1.4	1.2	-0.2	-1.3	1.2	0.7	-1.4
Delay discount exponential model param	0.4	0.5	1.2	1.0	0.7	0.4	-1.1	-0.8	0.4	0.2	0.0
Extinction: sum of active levers before priming	0.7	0.8	1.3	0.8	0.8	1.2	0.1	-1.1	-0.6	1.0	-0.9
Active lever presses in extinction session 6	0.6	0.6	2.5	-0.9	-0.6	-0.3	0.2	0.7	-1.6	0.2	0.1
Bone: final force	2.5	3.9	6.4	-2.4	-2.5	-2.4	1.6	1.9	-1.6	-1.0	2.0
Bone: final moment	2.6	4.2	7.2	-2.5	-2.7	-2.6	1.7	1.9	-1.7	-1.0	1.8
Food consumed during 24 hour testing period	0.1	0.2	0.4	0.3	0.1	-0.2	-0.4	-0.7	0.7	-0.1	-0.5
Glucose	2.2	3.4	5.8	-2.4	-1.9	-2.2	1.5	1.8	0.8	-2.2	1.2
Heart weight	2.3	3.6	5.4	-2.2	-2.2	-2.3	2.3	1.9	-0.1	-1.9	1.0
Delay discount hyperbolic model param	0.3	0.3	0.9	1.0	0.6	0.4	-0.8	-0.7	0.4	0.1	0.0
Intermittent access intake day 1-15 change	1.4	2.9	4.8	-2.0	-2.0	-1.9	0.3	2.0	-2.2	-0.7	1.5
Intermittent access intake escalation	1.3	2.6	4.7	-1.9	-1.9	-1.8	0.5	2.2	-1.8	-1.0	1.1
Intermittent access intake escalation 2	1.7	1.9	5.5	-1.4	-1.4	-1.3	-0.2	1.4	-2.3	-0.1	1.5
Intermitt. access day 1 inactive lever presses	0.5	2.0	4.5	-2.0	-1.4	-1.2	2.1	1.6	-0.6	-1.1	0.2
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.8	-0.5	-0.4	-0.1	0.4	0.5	-0.9	0.1	0.5
Intermitt. access escalation Index	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.1	0.2	-0.3	-0.1	-0.2
Intermittent access day 1 total infusions	1.3	2.1	12.0	-0.8	-0.7	-0.1	-0.1	0.5	-3.5	1.3	1.2
Intermittent access day 15 total infusions	1.5	2.2	10.9	-1.3	-1.2	-0.7	-0.1	1.4	-3.3	0.6	1.1
Intermittent access terminal intake (last 3 days)	1.2	1.6	8.7	-0.9	-0.8	-0.4	-0.3	0.8	-3.0	0.8	0.8
Intermittent access total infusions	2.5	2.9	14.6	-1.2	-1.3	-0.6	0.0	1.5	-3.8	0.5	1.6
Intermittent access day 1 locomotion	1.1	1.5	6.6	-0.6	-0.7	-0.3	-0.7	0.4	-2.6	1.4	1.3
Intermittent access day 15 total locomotion	1.9	3.4	6.6	-2.1	-2.0	-1.9	1.3	2.6	-1.4	-1.6	1.4
Intermittent access total locomotion	1.7	2.0	5.1	-1.2	-1.3	-1.2	-0.5	1.5	-2.3	0.2	2.0
Intermittent access standard deviation	0.4	0.9	2.6	-1.2	-1.0	-0.7	0.7	1.0	-1.6	-0.3	0.6
Left kidney weight	1.6	7.6	16.3	-4.0	-3.6	-4.0	1.0	2.2	-2.1	-0.7	2.2
Right kidney weight	3.0	13.8	26.5	-5.1	-4.8	-5.1	1.5	3.2	-3.0	-1.4	3.4
Cocaine induced anxiety	3.5	5.0	8.4	2.1	2.3	2.1	-2.6	-2.9	0.4	2.8	-1.7
Post-drug Anxiety	0.8	0.9	2.1	0.4	0.8	0.5	-0.2	-1.3	1.4	0.4	-1.4
Baseline Anxiety	3.1	3.5	7.6	-1.7	-1.7	-1.7	2.7	1.8	1.1	-2.7	0.6
Tail length	0.2	0.9	1.9	-1.4	-1.1	-1.1	0.9	1.0	-0.9	-0.4	0.2
Length with tail	1.5	6.3	12.3	-3.5	-2.9	-3.1	2.5	2.7	-0.8	-2.3	0.9
Length without tail	4.1	13.1	23.2	-4.8	-4.1	-4.2	3.9	3.8	-1.0	-3.8	1.3
Times rat made contact with spout	0.9	1.0	3.8	-0.8	-1.0	-0.9	-0.1	0.8	-2.0	0.5	0.8
Lifetime Intake	3.0	3.6	18.2	-1.3	-1.5	-0.8	0.0	1.6	-4.3	0.6	1.8
Liver weight, left	4.6	7.6	15.9	-4.0	-3.5	-3.7	2.4	2.4	-1.4	-2.2	1.1
Liver weight, right	5.0	8.7	16.2	-3.8	-4.0	-4.0	1.3	2.4	-2.9	-0.6	2.7
Locomotor activity	1.4	2.1	3.5	-1.9	-1.7	-1.8	0.3	1.7	-0.8	-1.2	1.5
Locomotor testing distance	1.3	2.4	4.3	-1.4	-1.7	-1.8	-0.3	2.0	-1.3	-0.9	2.1
Locomotor testing rearing	0.7	1.5	2.6	-1.5	-1.4	-1.6	-0.2	1.4	-1.2	-0.6	1.0
Locomotion in novel chamber	0.7	0.9	2.9	-0.3	-0.1	-0.3	-1.7	-1.0	-0.9	1.5	0.8
Locomotion in novel chamber post-restriction	1.2	1.9	3.6	1.4	1.2	1.3	-1.9	-1.2	-1.5	1.7	0.3
Fecal boli incidents, locomotor time 1	0.7	1.0	3.6	0.1	-0.5	-0.3	1.0	1.4	0.5	-1.9	1.1
Change in fecal boli incidents, locomotor task	1.5	1.5	2.9	0.7	1.1	0.8	-1.0	-1.7	0.1	1.7	-1.6
Time >=10cm from walls, locomotor time 1	1.7	1.8	3.5	1.9	1.6	1.4	-0.8	-1.2	1.3	0.9	-1.4
Bouts of movement, locomotor time 1	1.1	1.2	4.2	-1.1	-1.0	-0.7	1.5	0.5	-2.0	-0.4	0.0
Total resting periods, locomotor time 1	1.0	1.1	4.5	-1.1	-1.0	-0.7	1.2	0.3	-2.1	-0.0	0.1
Rest time, locomotor task time 1	0.6	0.7	2.7	-0.3	-0.9	-0.6	-0.2	0.4	-1.6	0.8	1.0
Distance moved, locomotor task time 1	0.2	0.3	1.4	-0.1	0.3	0.1	0.2	-0.4	1.2	-0.8	-0.6
Vertical activity count, locomotor time 1	0.4	0.9	3.8	0.5	0.9	0.4	-0.7	-0.6	2.0	-0.3	-0.9
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.9	-0.5	-0.2	-0.4	0.7	0.4	0.6	-0.4	-1.0
Bouts of movement, locomotor time 2	1.2	2.0	5.2	0.7	1.4	1.2	-1.3	-2.3	-0.2	1.9	-1.0
Total resting periods, locomotor time 2	0.8	1.4	3.9	0.4	1.0	0.9	-1.1	-2.0	-0.5	1.8	-0.7
Rest time, locomotor task time 2	0.1	0.2	0.6	-0.3	-0.3	-0.4	-0.1	0.4	0.4	-0.3	0.8
Distance moved, locomotor task time 2	0.2	0.2	1.0	-0.2	-0.2	0.1	0.8	0.2	-1.0	-0.3	-0.1
Vertical activity count, locomotor time 2	0.2	0.3	0.8	-0.3	-0.3	-0.3	0.8	0.9	-0.1	-0.8	-0.3
Light reinforcement 1	1.0	2.3	4.3	1.6	1.6	1.6	-1.5	-2.0	-0.4	2.1	-0.6
Light reinforcement 2	2.1	3.2	6.5	1.5	1.8	1.7	-2.1	-2.4	-0.3	2.6	-0.8
Bone: marrow area	1.3	2.9	4.8	-2.2	-2.2	-2.2	2.1	1.4	-0.9	-1.0	0.5
Bone: maximum diameter	7.0	13.1	20.0	-4.5	-4.4	-4.2	4.1	3.7	-1.1	-3.4	2.1
Bone: maximum force	1.9	3.4	5.5	-2.3	-2.4	-2.3	1.5	1.8	-1.3	-1.1	1.7
Bone: maximum moment	2.0	3.6	6.0	-2.5	-2.4	-2.4	1.6	1.7	-1.4	-1.0	1.5
Mean time between licks in bursts	0.1	0.1	0.6	0.1	0.1	0.2	0.6	-0.2	0.3	-0.2	-0.8
Mean num. licks in bursts	0.7	1.1	2.6	-0.2	-0.5	-0.6	-1.3	1.0	-1.6	0.7	1.6
Cd content in liver	0.7	0.8	3.6	0.5	0.5	0.2	-1.9	-0.9	-0.1	1.2	0.5
Co content in liver	0.7	0.8	2.7	1.7	0.7	0.6	-1.0	-0.2	1.0	0.1	0.7
Cu content in liver	0.1	0.1	0.4	0.5	0.3	0.2	-0.6	-0.1	0.1	0.4	0.0
Fe content in liver	0.8	0.9	3.2	-0.5	-0.5	-0.4	1.8	0.8	0.9	-1.5	-0.4
K content in liver	0.4	0.4	0.8	0.8	0.9	0.9	-0.6	-0.4	0.2	0.5	-0.5
Mg content in liver	0.5	0.6	0.9	0.8	0.7	0.7	-0.6	-0.7	-0.3	0.9	-1.0
Mn content in liver	0.6	0.6	1.3	0.6	0.8	0.6	-0.8	-0.9	0.5	0.7	-1.2
Na content in liver	0.5	0.5	1.2	0.5	0.9	1.0	-0.4	-0.5	0.1	0.3	-1.1
Rb content in liver	2.0	2.3	5.3	1.6	1.8	1.8	-0.5	-1.4	1.1	0.8	-2.3
Se content in liver	0.7	0.8	1.5	1.1	1.2	1.2	-0.4	-0.7	0.8	0.2	-1.1
Sr content in liver	2.4	2.1	4.7	1.3	1.4	1.3	-2.2	-1.6	-0.8	1.9	-0.4
Zn content in liver	1.1	1.2	2.5	1.2	1.2	1.0	-1.6	-1.3	0.1	1.3	-0.5
Bone: minimum diameter	3.2	5.8	9.4	-3.1	-2.9	-2.9	3.0	2.4	-0.5	-2.0	0.9
Time in familiar zone, hab. session 1	0.4	0.4	1.7	0.5	0.3	0.1	-0.4	-0.0	1.3	-0.6	0.6
Time in novel zone, hab. session 1	0.6	0.6	1.5	-1.0	-0.8	-0.7	1.2	0.6	-0.8	-0.3	-0.5
Total zone transitions, hab. session 1	1.4	2.0	3.5	-1.6	-1.8	-1.6	0.1	1.2	-1.9	0.1	1.6
Total locomotion distance, hab. session 1	0.1	0.2	0.7	-0.2	-0.2	-0.1	-0.2	-0.1	-0.9	0.9	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	1.4	0.1	0.0	0.1	-0.6	-0.4	-1.0	1.2	-0.1
Time in familiar zone, hab. session 2	1.2	1.3	4.6	-0.9	-1.2	-1.0	2.1	0.8	0.1	-1.3	-0.1
Time in novel zone, hab. session 2	0.5	0.6	2.4	0.3	0.4	0.3	-1.5	-0.0	-0.6	0.8	0.9
Total zone transitions, hab. session 2	1.6	2.0	3.4	-1.6	-1.9	-1.7	0.4	1.3	-1.7	-0.1	1.6
Total locomotion distance, hab. session 2	0.6	0.8	2.4	-0.8	-1.1	-1.0	0.1	0.6	-1.6	0.7	0.6
Locomotion velocity, hab. session 2	0.4	0.6	1.9	-0.7	-0.8	-0.8	-0.1	0.3	-1.4	0.8	0.4
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.4	0.1	0.1	0.6	-0.2	0.7	-0.5	-0.6
Novelty place preference	0.1	0.2	0.4	-0.6	-0.1	-0.0	0.6	-0.0	0.2	-0.5	-0.5
Time in novel zone, NPP test	0.4	0.4	1.3	-0.9	-0.4	-0.3	1.1	0.3	0.2	-0.8	-0.4
Total zone transitions, NPP test	1.1	1.6	5.5	-1.3	-1.5	-1.3	0.1	0.6	-2.3	0.8	0.9
Total locomotion distance, NPP test	0.7	0.9	3.7	-0.8	-0.9	-0.8	0.1	0.1	-1.9	1.2	0.1
Locomotion velocity, NPP test	0.6	0.9	3.1	-0.3	-0.5	-0.5	-0.6	-0.3	-1.8	1.7	-0.0
Intraocular pressure	3.3	4.8	6.8	-2.1	-2.6	-2.1	2.5	2.6	-1.5	-2.0	1.9
Delta distance traveled before/after self-admin	0.8	0.8	1.8	-1.3	-0.9	-0.7	-0.0	-0.4	-1.3	1.2	0.4
Delta ambulatory time before/after self-admin	0.5	0.6	1.9	-1.4	-0.9	-0.7	0.7	-0.2	-1.0	0.5	-0.1
Parametrial fat weight	9.6	22.6	37.9	-5.6	-5.6	-5.4	6.2	4.7	-0.5	-4.9	2.4
Pavlov. Cond. lever latency	0.1	0.2	0.5	-0.2	-0.1	-0.1	0.7	0.4	-0.0	-0.7	-0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	0.6	-0.6	-0.6	-0.6	0.0	0.4	-0.8	0.3	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	-0.3	-0.2	-0.4	-0.3	-0.3	0.6	-0.0	0.1
Pavlov. Cond. index score	0.2	0.3	0.6	-0.8	-0.7	-0.7	-0.1	0.3	-0.2	0.0	0.6
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.6	-0.5	-0.6	-0.2	0.2	-0.2	0.1	0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.2	0.1	0.1	-0.4	-0.2	0.3	0.2	0.4
Pavlov. Cond. magazine entry number	1.0	1.3	2.3	1.4	1.5	1.5	-0.4	-1.2	0.7	0.5	-1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.7	0.2	-0.4	-0.2	0.1	0.4	-0.7	-0.2	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	-0.6	-0.5	-0.6	0.0	0.2	0.0	-0.0	0.4
Pavlov. Cond. response bias	0.2	0.2	0.6	-0.5	-0.5	-0.5	-0.3	0.4	-0.4	0.2	0.7
Pavlov. Cond. lever latency	0.4	0.5	1.5	0.6	0.5	0.1	-1.2	-0.9	1.2	0.3	0.1
Pavlov. Cond. magazine entry latency	1.0	1.3	3.6	-1.9	-1.3	-1.2	1.2	0.9	-0.9	-0.6	0.0
Pavlov. Cond. change in total contacts	0.8	1.3	2.6	-1.0	-1.0	-0.5	1.5	1.5	-1.6	-0.8	0.2
Pavlov. Cond. index score	1.2	1.7	3.2	-1.6	-1.4	-0.9	1.5	1.5	-1.8	-0.6	0.3
Pavlov. Cond. latency score	1.2	1.6	2.9	-1.7	-1.4	-1.0	1.5	1.4	-1.7	-0.6	0.3
Pavlov. Cond. lever contacts	0.4	0.6	2.4	-0.7	-0.7	-0.3	0.8	0.9	-1.6	-0.0	0.1
Pavlov. Cond. magazine entry number	0.9	1.2	3.0	1.7	1.2	1.0	-1.1	-1.0	1.2	0.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	-0.4	-0.3	-0.4	0.2	0.1	0.7	-0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	3.8	-1.7	-1.4	-1.0	1.3	1.6	-1.9	-0.6	0.5
Pavlov. Cond. response bias	0.7	1.0	1.8	-1.2	-1.0	-0.6	1.3	1.1	-1.3	-0.6	0.0
Time in closed arm before self-admin	0.4	0.6	2.6	0.1	0.3	-0.0	-0.5	-1.1	1.6	0.0	-0.6
Time in closed arm after self-admin	1.0	1.1	2.6	0.4	0.7	0.6	-1.6	-1.5	0.0	1.5	-0.6
Time in open arm before self-admin	0.9	1.0	1.8	1.2	1.3	1.4	-0.5	-0.5	0.1	0.9	-1.2
Time in open arm after self-admin	0.2	0.2	0.9	0.3	-0.1	0.3	1.0	0.1	-0.5	-0.2	0.4
Bone: periosteal estimation	4.8	10.2	16.2	-4.0	-4.0	-4.0	3.4	3.2	-1.5	-2.3	1.9
Bone: periosteal perimeter	9.2	15.8	23.9	-4.8	-4.9	-4.7	3.9	4.3	-1.8	-3.3	3.1
Bone: post-yield work	0.2	0.3	1.4	-0.0	0.1	0.2	0.4	-0.4	-0.3	0.6	-1.2
Progressive ratio test 1 active lever presses	3.0	3.7	21.7	-1.3	-1.3	-0.5	-0.2	0.7	-4.7	1.3	1.4
Progressive ratio test 1 breakpoint	3.0	3.7	22.0	-1.3	-1.3	-0.5	-0.2	0.7	-4.7	1.3	1.4
Progressive ratio test 1 inactive lever presses	1.0	1.5	8.7	-1.1	-0.8	-0.3	0.3	0.7	-3.0	0.4	0.7
Progressive ratio test 2 active lever presses	2.7	3.2	11.2	-2.0	-1.8	-1.3	0.5	1.7	-3.3	-0.1	1.5
Progressive ratio test 2 breakpoint	2.9	3.3	11.0	-2.0	-1.9	-1.3	0.6	1.8	-3.3	-0.2	1.5
Progressive ratio test 2 inactive lever presses	1.1	1.8	3.1	-1.8	-1.5	-1.2	1.1	1.4	-1.4	-1.0	1.1
Incentive Sensitization - Responses	1.1	1.5	3.2	-1.6	-1.3	-1.2	1.0	1.8	-0.6	-1.2	0.7
Incentive Sensitization - Breakpoint	1.1	1.4	3.1	-1.5	-1.2	-1.1	1.0	1.8	-0.4	-1.3	0.6
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.3	1.2	1.0	1.1	-0.1	-1.0	-0.2	0.7	-0.5
Progressive ratio	0.3	0.5	1.3	1.0	0.9	1.1	-0.3	-0.6	0.1	0.7	-0.4
Food seeking constrained by brief footshock	0.9	1.1	2.6	0.4	1.0	1.1	0.1	-1.4	1.3	0.1	-1.6
Seeking ratio, punishment vs. effort	0.1	0.2	0.8	-0.9	-0.4	-0.6	-0.1	0.0	-0.2	-0.3	-0.2
Retroperitoneal fat weight	10.0	42.8	65.6	-8.1	-7.7	-7.7	8.0	6.4	-0.5	-6.9	2.6
Reaction time number correct	0.5	0.9	1.6	-1.0	-1.1	-1.1	1.3	0.9	0.3	-1.1	0.1
Reaction time mean minus median	0.4	1.0	3.5	-0.8	-1.0	-0.6	0.3	1.2	-1.9	-0.0	1.1
Reaction time mean minus median AUC	0.6	1.4	5.3	-1.1	-1.1	-0.9	-0.4	0.9	-2.3	0.5	1.3
Reaction time num false alarms	0.1	0.2	0.7	0.2	0.1	0.2	-0.1	-0.5	-0.5	0.9	0.1
Reaction time num false alarms AUC	0.1	0.2	0.8	-0.0	-0.1	0.0	-0.2	-0.3	-0.6	0.9	0.4
Reaction time trials correct on left	0.5	0.9	1.6	-1.0	-1.1	-1.1	1.3	0.9	0.3	-1.1	0.1
Reaction time trials on left	0.5	1.0	1.8	-1.1	-1.2	-1.1	1.3	0.9	0.2	-1.2	0.1
Reaction time mean	0.4	0.7	1.7	-0.7	-0.7	-0.5	-0.1	1.3	-0.9	-0.6	1.2
Reaction time mean AUC	0.2	0.3	0.7	-0.3	-0.2	-0.1	-0.3	0.8	-0.7	-0.3	0.8
Median of all reaction times	0.3	0.5	1.3	-0.5	-0.4	-0.5	-0.3	1.1	-0.4	-0.6	1.1
Reaction time omissions	0.2	0.3	0.8	-0.7	-0.6	-0.5	0.9	0.2	-0.3	-0.4	-0.0
Reaction time false alarm rate	0.3	0.5	1.5	0.5	0.5	0.6	-0.6	-0.7	-0.6	1.2	0.1
Reaction time premature initiation rate	0.9	1.3	3.3	-0.6	-0.8	-0.8	-0.6	1.1	-1.8	0.5	1.8
Reaction time premature initiations	1.2	2.2	4.1	-1.3	-1.6	-1.6	0.2	1.8	-1.8	-0.1	2.0
Std. dev. reaction times	1.5	2.8	4.7	-1.7	-1.9	-1.5	0.9	2.2	-2.1	-0.8	1.7
Reaction time trials completed	0.5	1.0	1.8	-1.1	-1.2	-1.1	1.3	0.9	0.2	-1.2	0.1
Reaction time trials AUC	0.5	1.0	1.9	-1.1	-1.2	-1.2	1.4	1.0	0.1	-1.2	0.2
Run reversals in cocaine runway, females	1.3	1.3	2.3	-1.0	-1.3	-1.2	0.1	1.2	-1.5	-0.3	1.4
Run reversals in cocaine runway, males	1.5	1.5	2.4	1.0	1.4	1.3	-0.8	-1.4	1.2	0.9	-1.5
Latency to leave start box in cocaine runway	0.7	0.8	1.4	1.2	1.1	1.0	-0.6	-0.7	0.7	0.9	-0.5
Latency to leave start box in cocaine runway, F	1.3	1.5	2.8	1.6	1.3	1.1	-0.7	-1.5	1.7	0.7	-0.8
Latency to leave start box in cocaine runway, M	0.4	0.4	1.7	-0.6	-0.3	-0.1	0.1	0.9	-1.3	0.4	0.2
Std. dev. time between licks in bursts	0.5	0.6	1.5	1.0	0.5	0.8	0.3	-0.6	-0.7	1.2	-0.9
Total sessions with >9 infusions	4.1	5.0	15.7	-2.1	-2.3	-1.8	0.6	2.3	-4.0	-0.4	2.3
Short access day 1 total inactive lever presses	0.4	0.5	0.9	-1.0	-0.5	-0.5	0.6	0.8	-0.6	-0.5	-0.8
Short access day 10 total inactive lever presses	0.3	0.8	1.6	-1.1	-0.9	-1.0	0.5	1.3	-0.5	-0.7	0.7
Short access day 1 total infusions	1.2	1.5	7.8	-0.9	-1.0	-0.7	-0.4	0.9	-2.8	0.5	1.0
Short access day 10 total infusions	1.7	2.2	12.4	-0.0	-0.4	0.2	-1.0	0.2	-3.5	1.4	1.5
Short access total infusions	2.8	3.6	19.8	-0.9	-1.2	-0.6	-0.6	1.1	-4.4	1.1	1.8
Short access day 1 locomotion	1.6	2.0	11.0	-0.8	-1.0	-0.5	-0.1	0.5	-3.3	0.7	1.4
Short access day 10 total locomotion	0.7	1.3	2.6	-1.2	-1.5	-1.6	0.1	1.2	-0.5	-0.5	1.4
Short access total locomotion	2.2	2.7	9.7	-1.2	-1.5	-1.2	-0.4	1.1	-3.1	0.8	2.2
One hour access (0.3 mA shock)	1.6	1.8	8.8	-1.3	-1.1	-0.5	1.0	1.1	-3.0	-0.3	0.4
Compulsive drug intake	0.2	0.3	1.3	0.0	0.2	0.4	0.8	0.3	-0.3	-0.1	-1.1
One hour access (shock baseline)	1.0	1.5	5.7	-1.2	-1.2	-0.8	-0.1	0.7	-2.4	0.1	1.4
Social response proportion	2.8	3.1	6.4	-1.9	-2.0	-2.1	-0.3	1.5	-2.5	0.0	2.1
Social responses	4.8	6.2	9.0	-3.0	-3.0	-2.6	1.9	3.0	-2.7	-1.5	1.8
Social time	1.9	2.6	5.3	-2.3	-1.8	-1.7	0.1	1.5	-2.3	-0.4	1.2
Soleus weight	3.0	8.8	16.7	-4.1	-3.8	-4.0	1.5	2.6	-1.9	-1.5	2.9
Bone: stiffness	1.2	1.9	2.7	-1.7	-1.6	-1.6	0.9	1.5	-0.7	-1.0	1.5
Tibialis anterior weight	0.1	0.4	1.2	0.3	0.4	0.5	1.1	-0.4	1.1	-0.6	0.0
Time to tail flick, vehicle, before self-admin	0.9	1.0	3.3	-0.9	-0.8	-0.8	0.8	1.8	0.2	-1.4	0.3
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.9	1.0	0.6	0.5	0.0	0.0	0.7	-0.5	-0.8
Time to tail flick, test, before self-admin	1.8	1.9	5.3	-0.2	-0.6	-0.5	-1.8	0.3	-2.3	1.7	1.8
Time to tail flick, test, after self-admin	0.5	0.5	1.2	-1.1	-0.8	-0.5	1.1	0.7	-0.3	-0.3	0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.5	0.3	0.4	0.6	-0.4	0.4	-0.2	-0.7
Delta time to tail flick, test, before/after SA	0.9	0.9	2.8	-0.6	-0.5	-0.4	1.7	0.8	0.9	-1.5	0.1
Tibia length	1.6	4.4	8.6	-2.5	-2.8	-2.9	0.8	2.1	-1.7	-0.9	2.0
Ambulatory time before self-admin	0.5	0.7	2.3	-0.1	-0.4	-0.8	-1.5	0.1	-0.1	0.2	1.5
Ambulatory time after self-admin	0.9	1.0	2.1	-0.7	-0.8	-1.1	-1.3	-0.7	-0.7	1.0	1.4
Bone: tissue strength	0.3	0.3	0.5	0.4	0.6	0.6	-0.2	-0.7	0.3	0.3	-0.6
Total heroin consumption	1.3	1.5	2.6	-1.6	-1.4	-1.3	1.6	0.8	-1.3	-0.8	0.3
Bone: trabecular number	0.7	1.2	3.7	-0.8	-0.5	-0.6	1.9	0.3	1.4	-1.5	-0.5
Bone: trabecular spacing	0.1	0.1	0.3	0.1	0.5	0.5	-0.3	-0.1	0.6	0.0	-0.5
Bone: trabecular thickness	4.3	5.3	8.7	-2.7	-2.7	-2.6	2.9	2.4	-0.9	-2.3	0.8
Bone: trabecular tissue density	0.5	0.7	1.8	-0.6	-0.8	-0.7	-0.4	0.9	-1.2	-0.1	1.4
Water consumed over 24 hours	0.5	0.7	1.3	-0.9	-1.0	-1.1	-0.2	0.9	-0.8	-0.1	0.9
Number of responses in last shaping day	0.8	0.9	4.5	-0.2	-0.3	-0.0	-0.8	-0.1	-2.1	0.6	1.2