Hub : Genes

Nrap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Nrap 0.04 0.03 9.4e-04 0.03 0.03 0.01 0.03 1.1e-03 1.6e-03 1.7e-02 2.2e-03
2 IL alternative TSS XM_008760535.4 0.12 0.08 8.5e-03 0.07 0.1 0.06 0.07 7.9e-03 2.1e-03 1.4e-02 7.7e-03
3 pVTA intron excision ratio chr1_265376925_265377983 0.03 0.03 5.5e-03 0 0.01 0.01 0 1.2e-01 2.0e-02 2.7e-02 1.1e-01
4 NAcc alternative TSS XM_008760535.4 0.02 0.01 1.8e-03 0.02 0.02 0.02 0.02 5.1e-04 7.1e-04 4.2e-04 7.5e-04
5 Adipose gene expression Nrap 0.04 0.03 7.9e-05 0.03 0.03 0.03 0.02 1.9e-04 7.1e-04 3.0e-04 1.2e-03
6 NAcc intron excision ratio chr1_265356294_265356972 0.13 0.07 2.5e-03 0 0.01 0.02 0 2.2e-01 4.0e-03 1.5e-03 1.7e-01
7 NAcc gene expression Nrap 0.08 0.07 5.5e-03 0 0.01 0 0 3.3e-01 6.1e-03 6.5e-02 1.4e-01
8 IC isoform ratio XM_039110113.2 0.06 0.05 9.0e-03 0.08 0.04 0.05 0.06 3.1e-04 7.0e-03 4.1e-03 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.42.76.51.9-1.7-1.7-2.6-1.3-0.6-1.90.0
Area under the delay curve0.30.51.21.0-0.7-0.4-1.1-0.80.4-0.20.0
BMI with tail8.228.549.86.9-6.8-7.1-5.1-5.11.5-4.4-3.3
BMI without tail3.015.928.15.1-5.2-5.3-3.5-3.91.5-2.7-2.8
Body weight9.240.372.08.5-7.8-8.1-6.4-6.21.6-5.6-3.2
Weight adjusted by age2.67.710.82.8-3.3-3.1-1.7-3.22.7-2.0-2.9
Bone surface0.61.22.61.4-1.2-1.3-1.6-0.6-0.6-1.1-0.0
Bone volume2.03.96.72.6-2.3-2.4-2.6-1.70.0-2.0-0.6
Breakpoint value in progressive ratio session0.20.41.50.8-0.4-0.1-1.0-0.11.20.30.4
Number of licking bursts0.10.41.70.8-0.6-0.5-1.30.2-0.0-0.50.7
Context. condit. distance diff. score0.81.01.5-0.61.00.61.21.2-1.20.81.0
Locomotion velocity, session 10.60.71.9-1.40.81.20.70.20.70.6-0.4
Locomotion distance, session 10.50.72.0-0.6-0.10.11.1-0.31.10.6-1.4
Locomotion velocity, session 20.60.72.6-0.20.1-0.01.60.10.60.8-1.3
Locomotion distance, session 21.82.58.81.0-1.6-1.20.3-1.03.00.9-2.0
Locomotion velocity, session 30.70.82.40.2-0.3-0.21.0-0.51.60.6-1.4
Locomotion distance, session 30.81.02.40.3-0.4-0.51.4-0.31.40.8-1.6
Stereotopy head waving bouts, day 30.10.10.4-0.0-0.2-0.1-0.4-0.70.2-0.4-0.3
Stereotopy head waving duration, day 30.30.40.8-0.70.60.7-0.5-0.4-0.8-0.90.4
Locomotion velocity, session 70.20.20.50.7-0.5-0.5-0.4-0.3-0.2-0.5-0.4
Locomotion distance, session 70.10.20.80.00.2-0.00.40.6-0.90.3-0.1
Stereotopy head waving bouts, day 70.00.00.20.3-0.1-0.1-0.0-0.10.50.10.1
Stereotopy head waving duration, day 70.50.61.10.8-0.8-0.7-0.9-1.10.4-0.9-0.3
Locomotion velocity, session 81.72.02.7-1.61.71.41.51.6-1.01.21.3
Locomotion distance, session 80.71.03.2-0.60.60.41.81.10.41.70.0
Degree of sensitization distance1.41.54.2-0.61.00.9-0.71.2-2.00.12.1
Degree of sensitization stereotypy0.00.00.10.3-0.2-0.2-0.30.00.3-0.00.2
Conditioned locomotion0.10.10.2-0.40.30.30.50.10.00.4-0.2
Cocaine response after cond. corrected2.03.06.3-1.91.31.42.51.31.62.4-0.2
Cocaine response after cond. not corrected2.13.05.6-2.21.71.82.41.60.62.10.3
Cocaine response before conditioning1.01.25.6-0.20.70.5-0.70.5-2.4-1.01.4
Saline control response0.40.51.3-1.00.60.81.10.20.40.7-0.3
Bone: connectivity density0.40.62.40.10.1-0.1-0.90.2-1.5-0.90.7
Bone: cortical apparent density1.01.56.8-0.90.70.52.60.30.81.3-1.3
Bone: cortical area7.812.719.74.4-4.4-4.2-3.7-3.81.4-3.0-2.4
Bone: cortical porosity0.10.10.30.20.10.2-0.30.20.10.50.4
Bone: cortical porosity0.30.31.10.8-0.4-0.3-1.0-0.0-0.1-0.00.5
Bone: cortical thickness4.57.511.93.5-3.3-3.2-2.2-3.11.4-2.1-2.4
Bone: cortical thickness2.32.85.22.2-2.1-2.3-0.9-1.60.8-1.0-1.7
Bone: cortical tissue density1.11.77.3-1.10.90.72.70.50.71.4-1.1
Condit. Reinf. active minus inactive responses0.20.20.7-0.4-0.00.20.5-0.10.80.4-0.4
Condit. Reinf. active-inactive response ratio0.10.10.3-0.50.20.40.30.10.1-0.0-0.0
Condit. Reinf. active responses0.50.61.30.3-0.9-0.5-0.6-0.90.9-0.5-1.1
Condit. Reinf. inactive responses1.01.32.20.7-1.2-0.9-1.4-1.50.6-1.1-1.3
Incentive salience index mean0.40.61.3-0.80.30.60.90.31.10.9-0.7
Condit. Reinf. lever presses0.30.50.9-0.70.30.70.70.31.00.7-0.8
Condit. Reinf. active minus inactive responses1.21.86.20.4-0.9-0.4-2.5-1.6-0.3-2.1-0.4
Condit. Reinf. active-inactive response ratio0.20.42.1-0.3-0.10.2-1.4-0.3-0.3-0.8-0.1
Condit. Reinf. active responses2.53.69.11.4-1.6-1.1-3.0-2.4-0.2-2.8-0.6
Condit. Reinf. inactive responses1.42.04.71.4-1.2-0.9-1.8-2.0-0.4-2.2-0.2
Condit. Reinf. lever presses0.60.92.01.1-1.0-0.6-1.4-1.10.9-0.8-0.2
Condit. Reinf. lever reinforcers received1.82.56.51.1-1.4-0.8-2.5-2.10.2-2.3-0.5
Conditioned reinforcement - actives0.83.420.70.0-0.30.51.1-0.44.51.7-1.2
Conditioned reinforcement - inactives0.51.46.71.0-0.9-0.4-0.4-1.32.6-0.2-0.7
Conditioned locomotion2.02.913.90.1-0.50.01.5-0.33.71.9-1.9
Patch foraging indifference point 0 sec1.64.46.42.3-2.5-2.5-2.3-2.30.6-2.1-1.4
Patch foraging indifference point AUC0.10.31.20.0-0.10.4-0.9-0.11.10.30.5
Delay disc. indifference point, 0s delay0.60.71.91.1-0.9-0.8-0.3-0.81.40.3-0.3
Delay disc. indifference point, 16s delay0.10.10.80.4-0.10.2-0.9-0.1-0.10.20.2
Delay disc. indifference point, 2s delay0.20.20.80.20.30.20.50.30.40.90.6
Delay disc. indifference point, 24s delay0.40.72.60.8-0.4-0.1-1.6-0.3-0.9-0.60.9
Delay disc. indifference point, 4s delay0.10.10.4-0.00.20.30.10.20.30.50.6
Delay disc. indifference point, 8s delay2.13.56.02.0-2.1-1.5-2.1-2.51.6-1.3-1.6
Indifference point function ln k0.20.52.5-0.20.1-0.30.2-0.0-1.6-0.8-0.5
Indifference point function log k0.20.52.5-0.20.1-0.30.2-0.0-1.6-0.8-0.5
Patch foraging total patch changes 0 sec1.54.36.12.3-2.5-2.4-2.4-2.30.5-2.1-1.3
Patch foraging total patch changes 12 sec0.60.82.31.0-1.0-0.8-1.5-0.90.7-0.70.1
Patch foraging total patch changes 18 sec1.12.67.11.5-1.8-1.3-2.7-1.71.3-1.3-0.4
Patch foraging total patch changes 24 sec0.51.64.41.4-1.3-0.8-2.1-1.41.2-0.9-0.2
Patch foraging total patch changes 6 sec3.35.68.02.6-2.8-2.5-2.8-2.81.6-2.1-1.3
Patch foraging time to switch 0 sec0.20.61.6-0.50.90.81.30.80.21.10.4
Patch foraging water rate 0 sec0.31.02.10.5-1.0-1.0-1.2-1.2-0.5-1.4-0.7
Patch foraging water rate 12 sec0.62.65.71.1-1.0-1.2-2.2-1.2-2.2-2.4-0.1
Patch foraging water rate 18 sec0.40.81.51.0-1.1-1.1-0.2-0.90.7-0.4-1.2
Patch foraging water rate 24 sec1.21.73.01.2-1.7-1.7-0.7-1.21.6-0.1-1.4
Patch foraging water rate 6 sec0.40.61.20.6-0.9-1.1-0.4-1.00.0-0.4-1.0
Seeking ratio, delayed vs. immediate footshock0.60.92.4-0.40.40.41.11.01.41.6-0.1
Distance traveled before self-admin0.40.94.8-0.80.50.02.20.50.20.8-0.9
Distance traveled after self-admin0.81.53.50.3-0.4-0.51.90.81.51.7-1.3
Extensor digitorum longus weight0.31.23.01.2-0.9-1.0-1.7-0.5-1.0-1.4-0.1
Bone: elastic displacement0.00.00.10.00.10.1-0.10.3-0.20.10.3
Bone: elastic work1.11.52.71.5-1.5-1.60.0-0.91.2-0.1-1.5
Bone: endosteal estimation1.12.84.62.1-2.1-2.1-2.1-1.40.9-1.0-0.5
Bone: endosteal perimeter3.79.114.13.6-3.8-3.7-2.9-3.11.5-2.4-2.4
Epididymis fat weight6.935.055.47.4-6.7-6.8-7.1-5.9-0.3-6.5-2.2
Delta time in closed arm before/after self-admin0.30.20.70.0-0.1-0.10.8-0.40.70.6-0.4
Delta time in open arm before/after self-admin0.40.52.20.5-0.6-0.5-1.50.2-0.3-0.8-0.1
Diff in mean of infusions in LGA sessions0.81.42.1-1.31.41.20.21.3-1.20.71.4
Delay discount exponential model param0.30.51.2-1.00.70.41.10.8-0.40.2-0.0
Extinction: sum of active levers before priming0.50.81.3-0.80.81.2-0.11.10.61.00.9
Active lever presses in extinction session 60.60.62.50.9-0.6-0.3-0.2-0.71.60.2-0.1
Bone: final force2.43.96.42.4-2.5-2.4-1.6-1.91.6-1.0-2.0
Bone: final moment2.64.27.22.5-2.7-2.6-1.7-1.91.7-1.0-1.8
Food consumed during 24 hour testing period0.10.20.4-0.30.1-0.20.40.7-0.7-0.10.5
Glucose2.13.45.82.4-1.9-2.2-1.5-1.8-0.8-2.2-1.2
Heart weight2.23.65.42.2-2.2-2.3-2.3-1.90.1-1.9-1.0
Delay discount hyperbolic model param0.30.30.9-1.00.60.40.80.7-0.40.1-0.0
Intermittent access intake day 1-15 change0.52.94.82.0-2.0-1.9-0.3-2.02.2-0.7-1.5
Intermittent access intake escalation0.52.64.71.9-1.9-1.8-0.5-2.21.8-1.0-1.1
Intermittent access intake escalation 21.11.95.51.4-1.4-1.30.2-1.42.3-0.1-1.5
Intermitt. access day 1 inactive lever presses0.22.04.52.0-1.4-1.2-2.1-1.60.6-1.1-0.2
Intermitt. access day 15 inactive lever presses0.00.20.80.5-0.4-0.1-0.4-0.50.90.1-0.5
Intermitt. access escalation Index0.00.00.10.20.0-0.20.1-0.20.3-0.10.2
Intermittent access day 1 total infusions0.72.112.10.8-0.7-0.10.1-0.53.51.3-1.2
Intermittent access day 15 total infusions0.92.210.91.3-1.2-0.70.1-1.43.30.6-1.1
Intermittent access terminal intake (last 3 days)0.91.68.70.9-0.8-0.40.3-0.83.00.8-0.8
Intermittent access total infusions2.42.914.61.2-1.3-0.6-0.0-1.53.80.5-1.6
Intermittent access day 1 locomotion0.81.56.60.6-0.7-0.30.7-0.42.61.4-1.3
Intermittent access day 15 total locomotion0.93.46.62.1-2.0-1.9-1.3-2.61.4-1.6-1.4
Intermittent access total locomotion1.72.05.11.2-1.3-1.20.5-1.52.30.2-2.0
Intermittent access standard deviation0.20.92.61.2-1.0-0.7-0.7-1.01.6-0.3-0.6
Left kidney weight0.97.616.34.0-3.6-4.0-1.0-2.22.1-0.7-2.2
Right kidney weight2.013.826.55.1-4.8-5.1-1.5-3.23.0-1.4-3.4
Cocaine induced anxiety1.85.08.4-2.12.32.12.62.9-0.42.81.7
Post-drug Anxiety0.80.92.1-0.40.80.50.21.3-1.40.41.4
Baseline Anxiety2.13.57.61.7-1.7-1.7-2.7-1.8-1.1-2.7-0.6
Tail length0.20.91.91.4-1.1-1.1-0.9-1.00.9-0.4-0.2
Length with tail1.46.312.33.5-2.9-3.1-2.5-2.70.8-2.3-0.9
Length without tail2.513.123.24.8-4.1-4.2-3.9-3.81.0-3.8-1.3
Times rat made contact with spout0.91.03.80.8-1.0-0.90.1-0.82.00.5-0.8
Lifetime Intake2.93.618.21.3-1.5-0.8-0.0-1.64.30.6-1.8
Liver weight, left4.47.615.94.0-3.5-3.7-2.4-2.41.4-2.2-1.1
Liver weight, right5.08.716.23.8-4.0-4.0-1.3-2.42.9-0.6-2.7
Locomotor activity1.42.13.51.9-1.7-1.8-0.3-1.70.8-1.2-1.5
Locomotor testing distance1.02.44.31.4-1.7-1.80.3-2.01.3-0.9-2.1
Locomotor testing rearing0.41.52.61.5-1.4-1.60.2-1.41.2-0.6-1.0
Locomotion in novel chamber0.70.92.90.3-0.1-0.31.71.00.91.5-0.8
Locomotion in novel chamber post-restriction0.61.93.6-1.41.21.31.91.21.51.7-0.3
Fecal boli incidents, locomotor time 10.41.03.6-0.1-0.5-0.3-1.0-1.4-0.5-1.9-1.1
Change in fecal boli incidents, locomotor task1.41.52.9-0.71.10.81.01.7-0.11.71.6
Time >=10cm from walls, locomotor time 11.41.83.5-1.91.61.40.81.2-1.30.91.4
Bouts of movement, locomotor time 10.91.24.21.1-1.0-0.7-1.5-0.52.0-0.4-0.0
Total resting periods, locomotor time 10.91.14.51.1-1.0-0.7-1.2-0.32.1-0.0-0.1
Rest time, locomotor task time 10.50.72.70.3-0.9-0.60.2-0.41.60.8-1.0
Distance moved, locomotor task time 10.10.31.40.10.30.1-0.20.4-1.2-0.80.6
Vertical activity count, locomotor time 10.10.93.8-0.50.90.40.70.6-2.0-0.30.9
Time >=10cm from walls, locomotor time 20.10.30.90.5-0.2-0.4-0.7-0.4-0.6-0.41.0
Bouts of movement, locomotor time 20.62.05.2-0.71.41.21.32.30.21.91.0
Total resting periods, locomotor time 20.31.43.9-0.41.00.91.12.00.51.80.7
Rest time, locomotor task time 20.10.20.60.3-0.3-0.40.1-0.4-0.4-0.3-0.8
Distance moved, locomotor task time 20.20.21.00.2-0.20.1-0.8-0.21.0-0.30.1
Vertical activity count, locomotor time 20.10.30.80.3-0.3-0.3-0.8-0.90.1-0.80.3
Light reinforcement 10.52.34.3-1.61.61.61.52.00.42.10.6
Light reinforcement 21.43.26.5-1.51.81.72.12.40.32.60.8
Bone: marrow area1.22.94.82.2-2.2-2.2-2.1-1.40.9-1.0-0.5
Bone: maximum diameter6.513.120.04.5-4.4-4.2-4.1-3.71.1-3.4-2.1
Bone: maximum force1.73.45.52.3-2.4-2.3-1.5-1.81.3-1.1-1.7
Bone: maximum moment1.93.66.02.5-2.4-2.4-1.6-1.71.4-1.0-1.5
Mean time between licks in bursts0.00.10.6-0.10.10.2-0.60.2-0.3-0.20.8
Mean num. licks in bursts0.41.12.60.2-0.5-0.61.3-1.01.60.7-1.6
Cd content in liver0.70.83.6-0.50.50.21.90.90.11.2-0.5
Co content in liver0.60.82.7-1.70.70.61.00.2-1.00.1-0.7
Cu content in liver0.10.10.4-0.50.30.20.60.1-0.10.4-0.0
Fe content in liver0.80.93.20.5-0.5-0.4-1.8-0.8-0.9-1.50.4
K content in liver0.40.40.8-0.80.90.90.60.4-0.20.50.5
Mg content in liver0.50.60.9-0.80.70.70.60.70.30.91.0
Mn content in liver0.60.61.3-0.60.80.60.80.9-0.50.71.2
Na content in liver0.40.51.2-0.50.91.00.40.5-0.10.31.1
Rb content in liver2.02.35.3-1.61.81.80.51.4-1.10.82.3
Se content in liver0.70.81.5-1.11.21.20.40.7-0.80.21.1
Sr content in liver2.42.14.7-1.31.41.32.21.60.81.90.4
Zn content in liver1.11.22.5-1.21.21.01.61.3-0.11.30.5
Bone: minimum diameter3.05.89.43.1-2.9-2.9-3.0-2.40.5-2.0-0.9
Time in familiar zone, hab. session 10.30.41.7-0.50.30.10.40.0-1.3-0.6-0.6
Time in novel zone, hab. session 10.50.61.51.0-0.8-0.7-1.2-0.60.8-0.30.5
Total zone transitions, hab. session 11.42.03.51.6-1.8-1.6-0.1-1.21.90.1-1.6
Total locomotion distance, hab. session 10.10.20.70.2-0.2-0.10.20.10.90.90.1
Locomotion velocity, hab. session 10.30.41.4-0.10.00.10.60.41.01.20.1
Time in familiar zone, hab. session 21.11.34.60.9-1.2-1.0-2.1-0.8-0.1-1.30.1
Time in novel zone, hab. session 20.50.62.4-0.30.40.31.50.00.60.8-0.9
Total zone transitions, hab. session 21.62.03.41.6-1.9-1.7-0.4-1.31.7-0.1-1.6
Total locomotion distance, hab. session 20.60.82.40.8-1.1-1.0-0.1-0.61.60.7-0.6
Locomotion velocity, hab. session 20.40.61.90.7-0.8-0.80.1-0.31.40.8-0.4
Novel to familiar place preference ratio0.20.20.40.40.10.1-0.60.2-0.7-0.50.6
Novelty place preference0.10.20.40.6-0.1-0.0-0.60.0-0.2-0.50.5
Time in novel zone, NPP test0.40.41.30.9-0.4-0.3-1.1-0.3-0.2-0.80.4
Total zone transitions, NPP test1.11.65.51.3-1.5-1.3-0.1-0.62.30.8-0.9
Total locomotion distance, NPP test0.70.93.70.8-0.9-0.8-0.1-0.11.91.2-0.1
Locomotion velocity, NPP test0.60.93.10.3-0.5-0.50.60.31.81.70.0
Intraocular pressure2.94.86.82.1-2.6-2.1-2.5-2.61.5-2.0-1.9
Delta distance traveled before/after self-admin0.70.81.81.3-0.9-0.70.00.41.31.2-0.4
Delta ambulatory time before/after self-admin0.40.61.91.4-0.9-0.7-0.70.21.00.50.1
Parametrial fat weight9.622.637.95.6-5.6-5.4-6.2-4.70.5-4.9-2.4
Pavlov. Cond. lever latency0.10.20.50.2-0.1-0.1-0.7-0.40.0-0.70.4
Pavlov. Cond. magazine entry latency0.20.30.60.6-0.6-0.6-0.0-0.40.80.3-0.3
Pavlov. Cond. change in total contacts0.10.10.40.3-0.2-0.40.30.3-0.6-0.0-0.1
Pavlov. Cond. index score0.20.30.60.8-0.7-0.70.1-0.30.20.0-0.6
Pavlov. Cond. latency score0.10.20.30.6-0.5-0.60.2-0.20.20.1-0.6
Pavlov. Cond. lever contacts0.10.10.2-0.20.10.10.40.2-0.30.2-0.4
Pavlov. Cond. magazine entry number1.01.32.3-1.41.51.50.41.2-0.70.51.2
Pavlov. Cond. intertrial magazine entries0.20.20.7-0.2-0.4-0.2-0.1-0.40.7-0.2-0.8
Pavlov. Cond. lever-magazine prob. diff.0.10.20.40.6-0.5-0.6-0.0-0.2-0.0-0.0-0.4
Pavlov. Cond. response bias0.20.20.60.5-0.5-0.50.3-0.40.40.2-0.7
Pavlov. Cond. lever latency0.40.51.5-0.60.50.11.20.9-1.20.3-0.1
Pavlov. Cond. magazine entry latency0.91.33.61.9-1.3-1.2-1.2-0.90.9-0.6-0.0
Pavlov. Cond. change in total contacts0.51.32.61.0-1.0-0.5-1.5-1.51.6-0.8-0.2
Pavlov. Cond. index score1.11.73.21.6-1.4-0.9-1.5-1.51.8-0.6-0.3
Pavlov. Cond. latency score1.01.62.91.7-1.4-1.0-1.5-1.41.7-0.6-0.3
Pavlov. Cond. lever contacts0.40.62.40.7-0.7-0.3-0.8-0.91.6-0.0-0.1
Pavlov. Cond. magazine entry number0.91.23.0-1.71.21.01.11.0-1.20.50.1
Pavlov. Cond. intertrial magazine entries0.10.20.40.4-0.3-0.4-0.2-0.1-0.7-0.50.2
Pavlov. Cond. lever-magazine prob. diff.1.21.83.81.7-1.4-1.0-1.3-1.61.9-0.6-0.5
Pavlov. Cond. response bias0.71.01.81.2-1.0-0.6-1.3-1.11.3-0.6-0.0
Time in closed arm before self-admin0.30.62.6-0.10.3-0.00.51.1-1.60.00.6
Time in closed arm after self-admin0.91.12.6-0.40.70.61.61.5-0.01.50.6
Time in open arm before self-admin0.81.01.8-1.21.31.40.50.5-0.10.91.2
Time in open arm after self-admin0.20.20.9-0.3-0.10.3-1.0-0.10.6-0.2-0.4
Bone: periosteal estimation4.310.216.24.0-4.0-4.0-3.4-3.21.5-2.3-1.9
Bone: periosteal perimeter8.015.823.94.8-4.9-4.7-3.9-4.31.8-3.3-3.1
Bone: post-yield work0.20.31.40.00.10.2-0.40.40.30.61.2
Progressive ratio test 1 active lever presses2.13.721.81.3-1.3-0.50.2-0.74.71.3-1.4
Progressive ratio test 1 breakpoint2.23.722.01.3-1.3-0.50.2-0.74.71.3-1.4
Progressive ratio test 1 inactive lever presses0.61.58.81.1-0.8-0.3-0.3-0.73.00.4-0.7
Progressive ratio test 2 active lever presses2.33.211.22.0-1.8-1.3-0.5-1.73.3-0.1-1.5
Progressive ratio test 2 breakpoint2.63.311.02.0-1.9-1.3-0.6-1.83.3-0.2-1.5
Progressive ratio test 2 inactive lever presses0.61.83.11.8-1.5-1.2-1.1-1.41.4-1.0-1.1
Incentive Sensitization - Responses0.51.53.21.6-1.3-1.2-1.0-1.80.6-1.2-0.7
Incentive Sensitization - Breakpoint0.61.43.11.5-1.2-1.1-1.0-1.80.4-1.3-0.6
Sum of active levers in priming session hrs 5-60.70.71.3-1.21.01.10.11.00.20.70.5
Progressive ratio0.20.51.3-1.00.91.10.30.6-0.10.70.4
Food seeking constrained by brief footshock0.91.12.6-0.41.01.1-0.11.4-1.30.11.6
Seeking ratio, punishment vs. effort0.10.20.80.9-0.4-0.60.1-0.00.2-0.30.2
Retroperitoneal fat weight9.642.865.68.1-7.7-7.7-8.0-6.40.5-6.9-2.6
Reaction time number correct0.20.91.61.0-1.1-1.1-1.3-0.9-0.3-1.1-0.1
Reaction time mean minus median0.21.03.40.8-1.0-0.6-0.3-1.21.9-0.0-1.1
Reaction time mean minus median AUC0.21.45.21.1-1.1-0.90.4-0.92.30.5-1.3
Reaction time num false alarms0.10.20.7-0.20.10.20.10.50.50.9-0.1
Reaction time num false alarms AUC0.10.20.80.0-0.10.00.20.30.60.9-0.4
Reaction time trials correct on left0.20.91.61.0-1.1-1.1-1.3-0.9-0.3-1.1-0.1
Reaction time trials on left0.31.01.81.1-1.2-1.1-1.3-0.9-0.2-1.2-0.1
Reaction time mean0.30.71.70.7-0.7-0.50.1-1.30.9-0.6-1.2
Reaction time mean AUC0.10.30.70.3-0.2-0.10.3-0.80.7-0.3-0.8
Median of all reaction times0.30.51.30.5-0.4-0.50.3-1.10.4-0.6-1.1
Reaction time omissions0.20.30.80.7-0.6-0.5-0.9-0.20.3-0.40.0
Reaction time false alarm rate0.30.51.5-0.50.50.60.60.70.61.2-0.1
Reaction time premature initiation rate0.81.33.30.6-0.8-0.80.6-1.11.80.5-1.8
Reaction time premature initiations0.72.24.11.3-1.6-1.6-0.2-1.81.8-0.1-2.0
Std. dev. reaction times0.82.84.71.7-1.9-1.5-0.9-2.22.1-0.8-1.7
Reaction time trials completed0.31.01.81.1-1.2-1.1-1.3-0.9-0.2-1.2-0.1
Reaction time trials AUC0.31.01.91.1-1.2-1.2-1.4-1.0-0.1-1.2-0.2
Run reversals in cocaine runway, females1.11.32.31.0-1.3-1.2-0.1-1.21.5-0.3-1.4
Run reversals in cocaine runway, males1.31.52.4-1.01.41.30.81.4-1.20.91.5
Latency to leave start box in cocaine runway0.60.81.4-1.21.11.00.60.7-0.70.90.5
Latency to leave start box in cocaine runway, F1.21.52.8-1.61.31.10.71.5-1.70.70.8
Latency to leave start box in cocaine runway, M0.40.41.70.6-0.3-0.1-0.1-0.91.30.4-0.2
Std. dev. time between licks in bursts0.30.61.5-1.00.50.8-0.30.60.71.20.9
Total sessions with >9 infusions4.05.015.72.1-2.3-1.8-0.6-2.34.0-0.4-2.3
Short access day 1 total inactive lever presses0.20.50.91.0-0.5-0.5-0.6-0.80.6-0.50.8
Short access day 10 total inactive lever presses0.10.81.61.1-0.9-1.0-0.5-1.30.5-0.7-0.7
Short access day 1 total infusions0.81.57.80.9-1.0-0.70.4-0.92.80.5-1.0
Short access day 10 total infusions1.32.212.40.0-0.40.21.0-0.23.51.4-1.5
Short access total infusions2.53.619.80.9-1.2-0.60.6-1.14.41.1-1.8
Short access day 1 locomotion1.22.011.00.8-1.0-0.50.1-0.53.30.7-1.4
Short access day 10 total locomotion0.31.32.61.2-1.5-1.6-0.1-1.20.5-0.5-1.4
Short access total locomotion1.82.79.61.2-1.5-1.20.4-1.13.10.8-2.2
One hour access (0.3 mA shock)1.51.88.91.3-1.1-0.5-1.0-1.13.0-0.3-0.4
Compulsive drug intake0.20.31.3-0.00.20.4-0.8-0.30.3-0.11.1
One hour access (shock baseline)0.61.55.81.2-1.2-0.80.1-0.72.40.1-1.4
Social response proportion2.53.16.41.9-2.0-2.10.3-1.52.50.0-2.1
Social responses4.76.29.03.0-3.0-2.6-1.9-3.02.7-1.5-1.8
Social time1.62.65.32.3-1.8-1.7-0.1-1.52.3-0.4-1.2
Soleus weight3.08.816.74.1-3.8-4.0-1.5-2.61.9-1.5-2.9
Bone: stiffness1.01.92.71.7-1.6-1.6-0.9-1.50.7-1.0-1.5
Tibialis anterior weight0.10.41.2-0.30.40.5-1.10.4-1.1-0.6-0.0
Time to tail flick, vehicle, before self-admin0.81.03.30.9-0.8-0.8-0.8-1.8-0.2-1.4-0.3
Time to tail flick, vehicle, after self-admin0.20.40.9-1.00.60.5-0.0-0.0-0.7-0.50.8
Time to tail flick, test, before self-admin1.61.95.30.2-0.6-0.51.8-0.32.31.7-1.8
Time to tail flick, test, after self-admin0.50.51.21.1-0.8-0.5-1.1-0.70.3-0.3-0.4
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.50.30.4-0.60.4-0.4-0.20.7
Delta time to tail flick, test, before/after SA0.70.92.80.6-0.5-0.4-1.7-0.8-0.9-1.5-0.1
Tibia length1.64.48.62.5-2.8-2.9-0.8-2.11.7-0.9-2.0
Ambulatory time before self-admin0.20.72.30.1-0.4-0.81.5-0.10.10.2-1.5
Ambulatory time after self-admin0.61.02.10.7-0.8-1.11.30.70.71.0-1.4
Bone: tissue strength0.20.30.5-0.40.60.60.20.7-0.30.30.6
Total heroin consumption1.21.52.61.6-1.4-1.3-1.6-0.81.3-0.8-0.3
Bone: trabecular number0.61.23.70.8-0.5-0.6-1.9-0.3-1.4-1.50.5
Bone: trabecular spacing0.10.10.3-0.10.50.50.30.1-0.60.00.5
Bone: trabecular thickness3.85.38.72.7-2.7-2.6-2.9-2.40.8-2.3-0.8
Bone: trabecular tissue density0.40.71.80.6-0.8-0.70.4-0.91.2-0.1-1.4
Water consumed over 24 hours0.40.71.30.9-1.0-1.10.2-0.90.8-0.1-0.9
Number of responses in last shaping day0.70.94.50.2-0.3-0.00.80.12.10.6-1.2