Hub : Genes

Flrt3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Flrt3 0.12 0.08 1.3e-08 0.11 0.11 0.12 0.11 1.9e-09 2.1e-09 1.2e-09 3.1e-09
2 PL gene expression Flrt3 0.06 0.03 2.3e-06 0.03 0.05 0.05 0.05 8.4e-04 1.6e-06 2.4e-06 1.4e-06
3 IC gene expression Flrt3 0.06 0.04 7.0e-03 0.06 0.06 0.04 0.04 1.8e-03 2.3e-03 7.4e-03 5.7e-03
4 BLA gene expression Flrt3 0.06 0.04 3.7e-03 0.05 0.04 0.05 0.04 1.7e-03 3.2e-03 1.5e-03 4.0e-03
5 NAcc gene expression Flrt3 0.06 0.04 2.4e-07 0.04 0.04 0.04 0.04 4.4e-07 2.9e-07 1.1e-06 7.3e-07
6 Liver gene expression Flrt3 0.07 0.08 1.1e-03 0.01 0.01 0.01 0.01 2.0e-02 1.3e-02 3.1e-02 3.2e-02
7 Adipose gene expression Flrt3 0.11 0.08 7.5e-08 0.03 0.05 0.03 0.04 1.4e-04 3.1e-06 9.8e-05 1.1e-05
8 Brain gene expression Flrt3 0.1 0.07 1.0e-05 0.06 0.06 0.03 0.06 1.9e-06 2.2e-06 6.6e-04 5.0e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.03.9-1.2-0.7-0.8-0.12.00.40.61.2
Area under the delay curve0.20.30.80.40.60.90.5-0.60.40.10.1
BMI with tail4.415.226.7-4.9-5.2-5.2-4.32.1-3.4-2.8-1.1
BMI without tail3.29.817.7-3.9-4.2-4.2-3.41.6-2.8-2.4-0.6
Body weight5.926.047.0-6.8-6.9-6.8-5.43.5-4.0-3.3-0.6
Weight adjusted by age0.50.71.7-0.8-0.4-0.90.01.30.50.61.3
Bone surface0.40.82.6-1.6-1.0-1.1-0.80.6-0.4-0.4-0.1
Bone volume0.40.72.1-1.5-1.0-1.1-0.71.0-0.3-0.20.1
Breakpoint value in progressive ratio session0.10.10.3-0.5-0.5-0.2-0.60.2-0.1-0.20.3
Number of licking bursts0.10.20.6-0.3-0.5-0.50.10.80.20.30.6
Context. condit. distance diff. score0.20.20.30.60.50.50.50.30.40.50.5
Locomotion velocity, session 10.20.20.50.50.60.70.4-0.60.20.1-0.2
Locomotion distance, session 10.70.92.00.81.21.20.7-1.40.1-0.1-1.1
Locomotion velocity, session 21.51.83.11.31.61.61.8-0.41.41.10.8
Locomotion distance, session 21.52.14.01.52.02.01.8-1.21.20.80.0
Locomotion velocity, session 30.20.20.60.40.30.40.0-0.8-0.3-0.4-0.5
Locomotion distance, session 30.00.00.0-0.00.0-0.0-0.10.0-0.2-0.10.0
Stereotopy head waving bouts, day 30.70.81.4-1.1-1.1-1.2-1.10.2-0.9-0.8-0.5
Stereotopy head waving duration, day 30.30.40.6-0.5-0.7-0.7-0.8-0.3-0.7-0.7-0.5
Locomotion velocity, session 71.61.82.31.51.51.41.50.21.51.41.2
Locomotion distance, session 70.10.10.3-0.1-0.1-0.1-0.20.60.10.20.5
Stereotopy head waving bouts, day 70.30.40.5-0.6-0.6-0.7-0.7-0.2-0.7-0.7-0.5
Stereotopy head waving duration, day 70.81.01.6-0.8-0.8-0.8-1.0-0.9-1.1-1.2-1.2
Locomotion velocity, session 81.31.52.71.51.61.71.4-0.61.10.90.5
Locomotion distance, session 81.01.52.71.41.61.61.5-0.61.10.90.2
Degree of sensitization distance0.00.00.1-0.3-0.2-0.2-0.10.30.10.10.1
Degree of sensitization stereotypy0.00.00.1-0.1-0.1-0.1-0.1-0.3-0.2-0.3-0.2
Conditioned locomotion1.82.13.8-1.6-1.9-1.9-1.81.0-1.4-1.0-0.2
Cocaine response after cond. corrected1.92.23.11.31.51.61.70.61.81.61.6
Cocaine response after cond. not corrected1.51.72.51.11.31.41.40.51.61.51.3
Cocaine response before conditioning0.10.10.4-0.7-0.4-0.4-0.40.1-0.2-0.2-0.4
Saline control response0.20.30.6-0.5-0.7-0.8-0.50.4-0.5-0.3-0.3
Bone: connectivity density0.81.34.3-1.1-0.3-0.40.42.10.91.01.6
Bone: cortical apparent density0.40.51.0-0.3-0.9-0.7-1.0-0.3-0.9-0.8-0.4
Bone: cortical area1.21.94.0-1.3-1.9-1.8-1.12.0-0.7-0.20.8
Bone: cortical porosity1.92.05.8-1.3-0.4-0.30.52.41.31.32.2
Bone: cortical porosity2.32.57.5-1.1-0.4-0.30.72.71.41.62.4
Bone: cortical thickness1.83.08.1-1.5-2.2-2.1-1.32.8-0.7-0.01.5
Bone: cortical thickness1.01.24.6-0.6-0.8-0.8-0.02.10.30.71.5
Bone: cortical tissue density0.40.50.9-0.2-0.8-0.6-0.9-0.5-0.9-0.8-0.6
Condit. Reinf. active minus inactive responses0.80.92.0-1.4-1.2-1.1-0.90.8-0.6-0.50.1
Condit. Reinf. active-inactive response ratio0.50.62.0-0.4-0.1-0.10.21.40.60.71.2
Condit. Reinf. active responses0.40.50.8-0.9-0.8-0.8-0.7-0.2-0.7-0.7-0.6
Condit. Reinf. inactive responses0.91.13.2-0.2-0.3-0.2-0.7-1.7-1.0-1.2-1.8
Incentive salience index mean0.20.20.4-0.6-0.4-0.4-0.5-0.3-0.4-0.5-0.6
Condit. Reinf. lever presses0.60.83.20.40.50.5-0.1-1.8-0.4-0.7-1.4
Condit. Reinf. active minus inactive responses0.10.10.40.30.10.10.0-0.4-0.2-0.1-0.6
Condit. Reinf. active-inactive response ratio0.10.20.30.40.60.50.5-0.30.40.3-0.1
Condit. Reinf. active responses0.40.62.00.1-0.2-0.2-0.5-1.0-0.8-0.8-1.4
Condit. Reinf. inactive responses1.31.63.8-0.5-0.8-0.9-1.2-1.2-1.5-1.5-1.9
Condit. Reinf. lever presses1.21.74.8-0.2-0.5-0.5-0.9-1.8-1.3-1.5-2.2
Condit. Reinf. lever reinforcers received0.50.72.40.3-0.0-0.1-0.4-1.3-0.7-0.8-1.5
Conditioned reinforcement - actives1.11.83.90.60.61.11.21.51.61.72.0
Conditioned reinforcement - inactives0.00.00.10.1-0.10.0-0.2-0.3-0.3-0.3-0.3
Conditioned locomotion1.21.62.11.31.21.41.40.41.41.41.2
Patch foraging indifference point 0 sec0.50.82.80.80.60.60.1-1.4-0.5-0.5-1.7
Patch foraging indifference point AUC2.43.56.92.62.42.41.8-1.91.10.8-0.5
Delay disc. indifference point, 0s delay0.20.20.4-0.10.60.10.60.20.60.40.4
Delay disc. indifference point, 16s delay0.50.51.20.61.01.10.6-0.60.80.50.2
Delay disc. indifference point, 2s delay0.20.20.60.10.60.50.8-0.30.30.1-0.3
Delay disc. indifference point, 24s delay0.60.71.2-0.7-0.4-0.4-1.1-1.0-0.7-1.0-1.0
Delay disc. indifference point, 4s delay0.20.20.40.20.30.60.50.10.60.50.6
Delay disc. indifference point, 8s delay0.10.10.40.3-0.10.6-0.0-0.6-0.2-0.4-0.1
Indifference point function ln k1.93.36.1-2.5-2.3-2.3-1.82.2-1.1-0.60.4
Indifference point function log k1.93.36.1-2.5-2.3-2.3-1.82.2-1.1-0.60.4
Patch foraging total patch changes 0 sec0.71.33.81.10.70.80.2-1.9-0.6-0.7-1.9
Patch foraging total patch changes 12 sec1.01.34.20.90.60.70.1-2.0-0.6-0.8-1.8
Patch foraging total patch changes 18 sec3.04.79.92.72.72.61.4-3.10.50.1-2.0
Patch foraging total patch changes 24 sec1.83.06.52.22.22.01.3-2.50.40.0-1.3
Patch foraging total patch changes 6 sec1.52.26.81.71.01.20.3-2.6-0.6-0.8-2.1
Patch foraging time to switch 0 sec1.42.84.7-2.2-2.1-2.2-1.90.9-1.5-1.3-0.1
Patch foraging water rate 0 sec1.42.96.32.52.12.11.6-1.90.90.6-0.6
Patch foraging water rate 12 sec0.71.52.71.51.41.61.4-0.21.11.10.4
Patch foraging water rate 18 sec0.40.71.71.30.91.10.9-0.20.70.70.2
Patch foraging water rate 24 sec1.52.24.92.21.61.71.8-0.41.31.30.7
Patch foraging water rate 6 sec0.91.31.91.30.80.91.20.91.21.41.3
Seeking ratio, delayed vs. immediate footshock0.91.13.7-0.8-0.9-0.5-0.11.90.40.71.7
Distance traveled before self-admin0.20.20.60.50.80.40.4-0.70.40.2-0.0
Distance traveled after self-admin0.10.10.30.50.00.00.20.10.00.20.3
Extensor digitorum longus weight0.51.92.5-1.4-1.5-1.5-1.6-0.6-1.5-1.6-1.2
Bone: elastic displacement0.10.10.20.2-0.00.10.10.50.10.20.5
Bone: elastic work2.12.85.2-1.9-2.3-2.2-1.90.8-1.6-1.3-0.4
Bone: endosteal estimation0.61.22.6-1.6-1.1-1.3-1.0-0.4-0.9-1.1-1.2
Bone: endosteal perimeter0.10.20.4-0.4-0.3-0.5-0.3-0.2-0.4-0.4-0.7
Epididymis fat weight4.816.634.5-5.9-5.3-5.4-4.03.9-2.4-1.80.7
Delta time in closed arm before/after self-admin0.00.00.10.10.30.1-0.10.10.10.20.0
Delta time in open arm before/after self-admin2.32.33.8-1.2-1.9-1.9-1.4-0.3-1.9-1.7-1.3
Diff in mean of infusions in LGA sessions0.10.10.20.30.20.5-0.1-0.40.10.0-0.0
Delay discount exponential model param0.20.20.7-0.4-0.5-0.8-0.40.6-0.3-0.1-0.0
Extinction: sum of active levers before priming0.20.20.50.50.60.20.3-0.70.0-0.1-0.4
Active lever presses in extinction session 61.11.12.7-1.3-1.6-1.3-1.00.6-1.0-0.8-0.2
Bone: final force1.21.94.1-1.6-2.0-2.0-1.31.4-1.0-0.60.1
Bone: final moment1.42.24.5-1.8-2.1-2.1-1.41.4-1.1-0.70.1
Food consumed during 24 hour testing period5.27.111.2-3.4-3.0-3.0-3.20.0-2.7-2.6-1.8
Glucose0.60.92.0-1.1-1.4-1.4-0.81.0-0.7-0.40.3
Heart weight1.92.95.4-2.1-2.3-2.3-1.80.6-1.6-1.4-0.9
Delay discount hyperbolic model param0.10.10.4-0.2-0.3-0.6-0.40.4-0.3-0.1-0.0
Intermittent access intake day 1-15 change0.51.03.3-0.5-0.6-0.20.21.70.60.71.8
Intermittent access intake escalation0.40.92.7-0.8-0.9-0.4-0.11.70.30.51.6
Intermittent access intake escalation 20.30.41.0-1.0-0.9-0.6-0.50.4-0.4-0.50.1
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.10.00.1-0.00.20.10.1
Intermitt. access day 15 inactive lever presses0.91.93.7-1.9-1.8-1.8-1.50.9-1.0-0.9-0.2
Intermitt. access escalation Index0.40.61.1-1.0-1.0-1.1-0.80.1-0.6-0.6-0.2
Intermittent access day 1 total infusions0.91.43.6-1.2-1.7-1.2-0.71.9-0.20.21.1
Intermittent access day 15 total infusions1.82.66.8-1.6-2.3-1.5-1.02.6-0.30.11.7
Intermittent access terminal intake (last 3 days)1.72.25.0-1.7-2.2-1.5-1.12.2-0.5-0.11.3
Intermittent access total infusions1.51.84.3-1.5-2.1-1.5-1.21.7-0.8-0.40.7
Intermittent access day 1 locomotion0.10.20.5-0.3-0.7-0.4-0.40.6-0.3-0.00.2
Intermittent access day 15 total locomotion0.50.93.3-0.3-0.4-0.10.31.80.71.01.4
Intermittent access total locomotion0.10.10.30.1-0.40.2-0.10.5-0.00.20.5
Intermittent access standard deviation0.40.82.6-0.4-0.7-0.10.21.60.40.61.6
Left kidney weight0.42.05.7-1.8-1.5-1.7-0.72.4-0.00.31.0
Right kidney weight0.21.02.6-1.4-1.1-1.2-0.31.60.10.30.8
Cocaine induced anxiety0.40.61.5-0.4-0.3-0.3-0.6-0.9-0.9-1.0-1.2
Post-drug Anxiety0.60.60.9-0.8-0.7-0.8-0.9-0.3-0.9-0.9-0.8
Baseline Anxiety0.40.40.8-0.4-0.6-0.8-0.9-0.1-0.8-0.7-0.6
Tail length0.72.95.5-2.3-2.3-2.3-1.71.2-1.2-1.00.1
Length with tail2.08.518.5-4.3-3.8-3.8-3.02.0-2.1-1.8-0.3
Length without tail3.09.622.3-4.7-4.0-3.9-3.21.8-2.2-2.0-0.9
Times rat made contact with spout0.30.30.7-0.20.60.50.50.20.80.60.6
Lifetime Intake0.91.12.6-1.1-1.6-1.1-0.91.4-0.6-0.30.7
Liver weight, left0.91.52.6-1.1-1.6-1.4-1.60.4-1.3-1.1-0.4
Liver weight, right0.71.23.2-1.1-1.4-1.2-0.61.8-0.10.31.0
Locomotor activity1.21.93.3-1.2-0.9-1.1-1.4-1.5-1.5-1.8-1.5
Locomotor testing distance0.30.61.5-0.4-0.2-0.5-0.5-1.2-0.7-0.9-1.0
Locomotor testing rearing0.40.81.40.91.21.11.0-0.80.90.60.2
Locomotion in novel chamber0.20.20.70.3-0.4-0.40.00.80.10.40.7
Locomotion in novel chamber post-restriction0.20.30.91.00.60.80.6-0.30.20.30.0
Fecal boli incidents, locomotor time 10.10.10.40.4-0.20.0-0.3-0.6-0.3-0.3-0.3
Change in fecal boli incidents, locomotor task0.10.10.5-0.3-0.30.0-0.20.7-0.10.10.4
Time >=10cm from walls, locomotor time 11.01.13.00.3-0.00.40.61.70.91.21.6
Bouts of movement, locomotor time 13.33.86.71.01.71.42.11.12.62.42.5
Total resting periods, locomotor time 13.03.35.81.11.61.41.91.02.42.22.4
Rest time, locomotor task time 10.60.81.5-0.8-1.2-0.8-1.1-0.4-1.0-1.0-0.3
Distance moved, locomotor task time 10.50.81.31.11.11.01.00.20.91.00.4
Vertical activity count, locomotor time 10.00.10.4-0.4-0.0-0.40.10.60.20.3-0.0
Time >=10cm from walls, locomotor time 20.81.23.1-1.0-1.4-1.2-1.01.8-0.6-0.10.6
Bouts of movement, locomotor time 20.91.52.31.31.11.41.10.11.41.21.5
Total resting periods, locomotor time 20.50.91.71.00.91.20.8-0.21.10.81.3
Rest time, locomotor task time 20.10.10.70.20.1-0.2-0.3-0.8-0.2-0.4-0.0
Distance moved, locomotor task time 20.50.50.90.40.91.00.90.40.80.80.3
Vertical activity count, locomotor time 20.40.51.2-0.8-0.4-0.5-0.6-0.5-0.7-0.8-1.1
Light reinforcement 10.30.71.50.30.80.81.10.41.21.10.6
Light reinforcement 20.30.51.50.10.30.50.60.80.90.81.2
Bone: marrow area0.40.92.2-1.5-0.9-1.1-0.8-0.4-0.7-0.9-1.0
Bone: maximum diameter0.30.52.0-0.3-0.3-0.50.31.40.40.71.0
Bone: maximum force1.73.05.7-2.0-2.4-2.4-1.81.0-1.6-1.2-0.4
Bone: maximum moment2.03.56.6-2.2-2.6-2.6-2.01.0-1.7-1.4-0.5
Mean time between licks in bursts0.51.23.30.30.30.20.71.81.11.41.6
Mean num. licks in bursts0.10.10.2-0.30.30.2-0.3-0.5-0.0-0.2-0.4
Cd content in liver0.20.30.6-0.5-0.6-0.6-0.50.8-0.4-0.10.1
Co content in liver1.11.31.91.10.90.91.40.71.21.41.1
Cu content in liver0.70.81.8-0.3-0.3-0.3-0.8-1.3-1.0-1.1-1.3
Fe content in liver1.21.54.8-2.2-1.5-1.5-1.10.2-0.7-0.9-0.5
K content in liver1.71.63.51.71.51.51.1-1.90.40.1-0.7
Mg content in liver0.10.10.20.50.10.00.4-0.30.00.0-0.1
Mn content in liver2.32.56.52.51.71.71.3-2.00.30.2-1.4
Na content in liver0.40.50.90.11.00.90.8-0.90.70.2-0.2
Rb content in liver0.70.81.6-0.7-1.2-1.3-1.10.4-1.1-0.8-0.2
Se content in liver2.22.64.0-1.9-2.0-2.0-1.90.3-1.6-1.4-1.0
Sr content in liver0.60.51.10.80.90.90.5-1.10.1-0.1-0.5
Zn content in liver1.21.34.0-1.3-1.1-1.2-0.42.00.10.41.5
Bone: minimum diameter0.91.73.1-1.5-1.7-1.8-1.40.4-1.3-1.1-0.7
Time in familiar zone, hab. session 10.30.30.6-0.5-0.2-0.2-0.5-0.7-0.5-0.6-0.8
Time in novel zone, hab. session 10.50.50.90.90.70.70.90.00.60.70.5
Total zone transitions, hab. session 10.40.50.90.40.90.90.90.00.90.80.4
Total locomotion distance, hab. session 12.23.14.51.52.12.12.1-0.12.11.81.2
Locomotion velocity, hab. session 11.82.53.81.31.81.81.90.21.91.71.3
Time in familiar zone, hab. session 20.60.61.8-0.3-0.3-0.3-0.7-0.8-1.0-1.0-1.3
Time in novel zone, hab. session 20.40.41.20.00.30.20.60.70.90.81.1
Total zone transitions, hab. session 20.10.10.2-0.10.40.40.4-0.20.40.2-0.2
Total locomotion distance, hab. session 21.41.93.41.31.81.81.7-0.71.51.10.2
Locomotion velocity, hab. session 22.12.84.51.62.12.12.1-0.61.81.40.6
Novel to familiar place preference ratio1.51.63.7-0.00.50.41.21.61.61.61.9
Novelty place preference1.11.22.9-0.20.10.10.81.61.21.31.7
Time in novel zone, NPP test0.91.02.6-0.3-0.0-0.00.71.51.11.11.6
Total zone transitions, NPP test0.50.71.30.71.11.10.9-1.10.60.3-0.4
Total locomotion distance, NPP test2.73.76.21.92.52.52.4-0.92.01.60.6
Locomotion velocity, NPP test3.44.87.92.22.82.82.8-0.82.41.90.9
Intraocular pressure0.40.62.5-0.6-0.5-0.5-0.01.60.30.60.8
Delta distance traveled before/after self-admin0.00.00.20.5-0.30.00.10.2-0.3-0.0-0.0
Delta ambulatory time before/after self-admin0.20.20.60.2-0.6-0.2-0.5-0.1-0.8-0.5-0.5
Parametrial fat weight5.011.721.7-4.7-4.1-4.4-4.00.8-3.0-2.9-1.4
Pavlov. Cond. lever latency1.01.32.7-1.6-1.4-1.5-0.81.6-0.3-0.00.7
Pavlov. Cond. magazine entry latency1.62.03.1-1.6-1.5-1.4-1.7-0.3-1.5-1.5-1.2
Pavlov. Cond. change in total contacts0.30.31.10.50.30.3-0.1-1.1-0.2-0.4-0.7
Pavlov. Cond. index score0.40.51.3-0.0-0.2-0.1-0.6-1.0-0.8-0.9-1.1
Pavlov. Cond. latency score0.40.51.30.50.30.3-0.3-1.1-0.5-0.6-1.1
Pavlov. Cond. lever contacts0.60.71.81.11.01.00.5-1.30.1-0.1-0.8
Pavlov. Cond. magazine entry number1.51.92.91.11.31.21.70.71.61.61.5
Pavlov. Cond. intertrial magazine entries0.10.20.20.40.50.50.4-0.30.50.30.3
Pavlov. Cond. lever-magazine prob. diff.0.60.71.7-0.2-0.2-0.2-0.8-1.1-0.9-1.0-1.3
Pavlov. Cond. response bias0.60.71.1-0.8-0.7-0.7-1.1-0.4-1.0-1.0-0.9
Pavlov. Cond. lever latency0.40.51.00.81.01.00.7-0.40.60.40.5
Pavlov. Cond. magazine entry latency0.60.81.4-0.8-0.6-0.6-1.0-0.7-0.9-1.0-1.2
Pavlov. Cond. change in total contacts0.00.00.10.1-0.1-0.10.20.30.10.20.1
Pavlov. Cond. index score0.50.60.9-0.8-0.9-0.9-0.9-0.1-0.8-0.8-0.9
Pavlov. Cond. latency score0.20.30.4-0.6-0.7-0.6-0.60.1-0.5-0.4-0.6
Pavlov. Cond. lever contacts0.81.11.5-1.1-1.2-1.2-1.2-0.0-1.1-0.9-1.1
Pavlov. Cond. magazine entry number0.40.60.80.70.80.80.90.20.80.70.7
Pavlov. Cond. intertrial magazine entries0.50.71.2-0.8-0.5-0.6-0.9-0.7-0.9-1.0-1.1
Pavlov. Cond. lever-magazine prob. diff.0.50.60.9-0.9-0.9-0.9-0.9-0.0-0.8-0.7-0.8
Pavlov. Cond. response bias1.11.51.9-1.2-1.4-1.4-1.4-0.2-1.3-1.2-1.3
Time in closed arm before self-admin0.40.51.1-0.5-1.1-0.8-0.50.3-0.9-0.7-0.5
Time in closed arm after self-admin0.10.10.60.0-0.3-0.2-0.20.8-0.10.20.4
Time in open arm before self-admin2.83.15.80.61.61.61.61.12.42.22.2
Time in open arm after self-admin0.00.00.20.4-0.10.10.3-0.3-0.1-0.10.0
Bone: periosteal estimation0.81.73.4-1.7-1.7-1.9-1.30.8-1.0-0.8-0.4
Bone: periosteal perimeter0.10.20.9-0.2-0.2-0.30.31.00.30.50.6
Bone: post-yield work0.91.33.0-1.7-1.5-1.6-1.00.9-0.6-0.5-0.2
Progressive ratio test 1 active lever presses0.20.20.70.2-0.30.00.20.80.20.40.8
Progressive ratio test 1 breakpoint0.20.20.80.2-0.30.00.20.90.20.40.8
Progressive ratio test 1 inactive lever presses0.20.20.40.10.40.20.60.40.60.60.6
Progressive ratio test 2 active lever presses0.50.61.70.20.10.40.61.10.80.91.3
Progressive ratio test 2 breakpoint0.50.61.60.10.10.40.51.10.80.91.3
Progressive ratio test 2 inactive lever presses0.30.41.2-0.00.00.30.51.00.70.71.1
Incentive Sensitization - Responses0.60.91.60.50.80.81.00.71.31.21.1
Incentive Sensitization - Breakpoint0.60.81.40.50.80.80.90.61.21.11.0
Sum of active levers in priming session hrs 5-60.00.00.10.20.00.00.0-0.3-0.2-0.2-0.4
Progressive ratio0.40.62.0-0.1-0.1-0.20.41.30.70.81.4
Food seeking constrained by brief footshock1.92.34.51.92.11.91.6-0.51.41.30.6
Seeking ratio, punishment vs. effort0.60.81.61.01.21.30.6-1.10.40.1-0.7
Retroperitoneal fat weight6.628.253.4-7.3-6.8-7.1-5.93.1-4.1-3.6-0.9
Reaction time number correct0.50.92.51.61.11.30.7-1.20.30.1-0.2
Reaction time mean minus median0.81.93.9-2.0-1.4-1.6-1.6-0.2-1.2-1.3-1.0
Reaction time mean minus median AUC0.10.31.1-1.1-0.6-0.7-0.60.1-0.2-0.3-0.2
Reaction time num false alarms1.92.74.61.41.21.21.81.51.71.92.1
Reaction time num false alarms AUC1.62.63.71.71.41.51.90.91.61.81.8
Reaction time trials correct on left0.50.92.51.61.11.30.7-1.20.30.1-0.2
Reaction time trials on left0.51.02.61.61.21.30.7-1.20.30.2-0.2
Reaction time mean0.91.42.6-1.6-1.2-1.3-1.4-0.1-1.1-1.1-0.9
Reaction time mean AUC1.01.53.1-1.8-1.2-1.3-1.5-0.1-1.1-1.2-1.0
Median of all reaction times0.50.71.7-1.3-0.8-0.9-1.1-0.0-0.7-0.8-0.7
Reaction time omissions0.00.10.2-0.10.40.20.2-0.00.40.30.1
Reaction time false alarm rate1.21.73.00.90.80.81.51.31.41.61.7
Reaction time premature initiation rate0.30.51.2-0.9-0.9-0.8-0.21.10.20.30.4
Reaction time premature initiations0.10.10.30.20.10.20.40.30.60.60.3
Std. dev. reaction times0.71.32.7-1.6-1.1-1.4-1.40.0-1.0-1.0-0.8
Reaction time trials completed0.51.02.61.61.21.30.7-1.20.30.2-0.2
Reaction time trials AUC0.40.82.21.51.01.20.5-1.20.1-0.0-0.3
Run reversals in cocaine runway, females0.20.20.4-0.4-0.6-0.3-0.5-0.2-0.5-0.6-0.0
Run reversals in cocaine runway, males0.80.82.50.30.1-0.1-0.5-1.4-0.9-1.0-1.6
Latency to leave start box in cocaine runway2.32.65.7-1.7-2.4-1.6-2.01.5-1.4-1.00.5
Latency to leave start box in cocaine runway, F3.13.66.7-2.2-2.6-2.2-2.41.5-1.7-1.20.0
Latency to leave start box in cocaine runway, M0.20.20.50.1-0.70.0-0.40.4-0.3-0.10.7
Std. dev. time between licks in bursts1.01.32.50.50.60.71.31.41.31.41.6
Total sessions with >9 infusions0.10.10.3-0.3-0.5-0.4-0.40.3-0.4-0.30.2
Short access day 1 total inactive lever presses1.11.42.9-1.7-1.5-1.4-1.40.5-1.0-1.0-0.3
Short access day 10 total inactive lever presses0.71.73.7-1.9-1.1-1.4-1.2-0.6-1.1-1.4-1.4
Short access day 1 total infusions0.30.30.7-0.2-0.4-0.4-0.7-0.5-0.8-0.8-0.6
Short access day 10 total infusions0.30.41.10.1-0.10.20.41.00.60.71.1
Short access total infusions0.30.40.9-0.5-1.0-0.6-0.60.6-0.6-0.40.3
Short access day 1 locomotion0.10.10.30.50.10.30.0-0.3-0.1-0.1-0.0
Short access day 10 total locomotion0.71.32.11.31.51.41.4-0.51.11.00.5
Short access total locomotion0.60.71.51.21.01.10.9-0.50.60.50.2
One hour access (0.3 mA shock)0.40.51.00.50.30.90.70.40.70.71.0
Compulsive drug intake0.50.62.10.61.01.00.1-1.40.2-0.2-0.6
One hour access (shock baseline)0.40.62.1-0.6-0.9-0.40.21.40.10.40.9
Social response proportion4.55.16.6-2.5-2.3-2.6-2.5-0.6-2.5-2.5-2.2
Social responses0.30.40.9-0.8-0.5-0.9-0.3-0.1-0.3-0.4-0.8
Social time0.60.81.9-1.0-0.3-0.60.31.40.80.71.3
Soleus weight0.61.73.00.60.90.81.51.11.71.71.6
Bone: stiffness0.71.12.5-1.2-1.5-1.6-0.91.1-0.7-0.40.1
Tibialis anterior weight1.03.24.8-2.2-2.2-2.2-2.0-0.1-1.7-1.7-1.2
Time to tail flick, vehicle, before self-admin0.80.81.6-1.0-1.0-0.8-1.11.3-0.20.00.8
Time to tail flick, vehicle, after self-admin0.60.81.8-1.4-1.0-1.2-0.71.0-0.1-0.10.6
Time to tail flick, test, before self-admin0.10.10.3-0.10.00.40.30.50.40.40.6
Time to tail flick, test, after self-admin1.71.74.2-2.0-1.6-2.0-1.10.6-0.9-0.9-0.4
Delta time to tail flick, vehicle, before/after SA0.20.20.60.10.30.00.80.20.50.50.2
Delta time to tail flick, test, before/after SA1.21.32.1-1.1-0.9-1.5-1.1-0.7-1.1-1.2-1.2
Tibia length3.28.816.1-3.8-3.9-4.0-3.12.6-2.2-1.60.2
Ambulatory time before self-admin0.10.10.40.30.60.30.4-0.30.40.30.1
Ambulatory time after self-admin0.00.00.30.60.00.10.00.0-0.20.00.1
Bone: tissue strength0.10.10.3-0.3-0.2-0.1-0.5-0.4-0.4-0.5-0.3
Total heroin consumption0.20.30.40.50.50.70.50.10.60.60.6
Bone: trabecular number0.91.55.3-0.9-0.3-0.40.42.30.91.11.8
Bone: trabecular spacing0.71.02.00.3-0.3-0.3-0.9-1.4-1.2-1.2-1.3
Bone: trabecular thickness0.91.13.7-0.6-0.3-0.30.41.90.81.11.5
Bone: trabecular tissue density0.50.81.60.30.40.40.81.01.11.11.3
Water consumed over 24 hours1.21.72.4-1.2-1.0-1.1-1.4-1.0-1.4-1.6-1.5
Number of responses in last shaping day0.91.02.00.50.70.71.00.91.11.21.4