Prdx3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Prdx3 0.18 0.08 0.0e+00 0.22 0.22 0.22 0.22 1.2e-24 8.3e-24 2.6e-24 2.3e-24
2 Brain gene expression Prdx3 0.03 0.02 9.7e-03 0 0.01 0 0 1.8e-01 2.6e-02 2.0e-01 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.81.32.51.6-0.3
Area under the delay curve0.20.20.40.60.3
BMI with tail13.744.268.38.3-4.5
BMI without tail8.016.629.15.4-2.0
Body weight11.849.378.78.9-4.5
Weight adjusted by age2.73.14.42.1-1.3
Bone surface1.12.03.71.9-0.5
Bone volume2.64.47.22.7-1.2
Breakpoint value in progressive ratio session0.60.61.21.10.2
Number of licking bursts0.91.01.5-0.81.2
Context. condit. distance diff. score0.10.10.1-0.30.3
Locomotion velocity, session 11.21.31.9-1.40.8
Locomotion distance, session 10.20.20.5-0.7-0.0
Locomotion velocity, session 20.40.50.8-0.9-0.5
Locomotion distance, session 21.52.02.21.4-1.5
Locomotion velocity, session 30.40.50.6-0.80.6
Locomotion distance, session 30.20.20.4-0.60.2
Stereotopy head waving bouts, day 30.10.10.2-0.0-0.4
Stereotopy head waving duration, day 30.00.00.1-0.1-0.3
Locomotion velocity, session 70.10.10.1-0.10.4
Locomotion distance, session 70.50.70.70.9-0.8
Stereotopy head waving bouts, day 71.21.42.5-0.51.6
Stereotopy head waving duration, day 72.02.44.1-0.92.0
Locomotion velocity, session 81.31.52.0-1.41.1
Locomotion distance, session 80.00.10.1-0.4-0.0
Degree of sensitization distance0.90.91.21.1-0.8
Degree of sensitization stereotypy1.11.22.3-0.31.5
Conditioned locomotion0.10.10.2-0.50.2
Cocaine response after cond. corrected1.51.73.3-0.3-1.8
Cocaine response after cond. not corrected1.01.11.3-1.2-0.9
Cocaine response before conditioning3.13.74.6-1.72.1
Saline control response0.10.20.3-0.2-0.6
Bone: connectivity density0.20.30.50.70.3
Bone: cortical apparent density1.62.14.3-2.1-0.0
Bone: cortical area4.77.111.13.3-1.7
Bone: cortical porosity0.80.91.81.30.2
Bone: cortical porosity1.51.73.31.80.2
Bone: cortical thickness4.98.010.83.3-2.3
Bone: cortical thickness8.29.612.73.6-2.5
Bone: cortical tissue density1.92.55.0-2.20.1
Condit. Reinf. active minus inactive responses0.91.01.4-1.20.7
Condit. Reinf. active-inactive response ratio1.51.62.1-1.51.0
Condit. Reinf. active responses0.00.00.0-0.1-0.1
Condit. Reinf. inactive responses0.70.81.11.1-0.8
Incentive salience index mean0.10.20.3-0.50.2
Condit. Reinf. lever presses0.10.10.10.4-0.4
Condit. Reinf. active minus inactive responses0.30.30.60.30.8
Condit. Reinf. active-inactive response ratio0.50.50.70.80.5
Condit. Reinf. active responses0.30.40.70.40.8
Condit. Reinf. inactive responses0.10.20.3-0.10.6
Condit. Reinf. lever presses0.30.40.80.9-0.1
Condit. Reinf. lever reinforcers received0.30.40.8-0.10.9
Conditioned reinforcement - actives2.72.74.2-2.01.1
Conditioned reinforcement - inactives0.20.20.3-0.30.5
Conditioned locomotion1.82.24.0-2.00.7
Patch foraging indifference point 0 sec3.86.110.63.3-1.3
Patch foraging indifference point AUC0.10.10.10.3-0.2
Delay disc. indifference point, 0s delay1.01.11.71.3-0.8
Delay disc. indifference point, 16s delay0.30.30.70.00.8
Delay disc. indifference point, 2s delay0.30.30.40.6-0.5
Delay disc. indifference point, 24s delay0.20.20.50.70.2
Delay disc. indifference point, 4s delay0.20.20.30.50.2
Delay disc. indifference point, 8s delay0.00.00.10.30.1
Indifference point function ln k0.60.91.30.7-1.1
Indifference point function log k0.60.91.30.7-1.1
Patch foraging total patch changes 0 sec4.47.212.33.5-1.4
Patch foraging total patch changes 12 sec2.12.85.22.3-0.6
Patch foraging total patch changes 18 sec0.91.22.21.5-0.5
Patch foraging total patch changes 24 sec0.40.51.01.00.1
Patch foraging total patch changes 6 sec2.13.15.62.4-0.8
Patch foraging time to switch 0 sec1.01.62.1-1.51.0
Patch foraging water rate 0 sec2.84.46.52.5-1.5
Patch foraging water rate 12 sec1.21.93.41.8-0.5
Patch foraging water rate 18 sec2.63.53.61.9-1.9
Patch foraging water rate 24 sec5.67.88.02.8-2.8
Patch foraging water rate 6 sec2.43.63.71.8-1.9
Seeking ratio, delayed vs. immediate footshock3.03.45.7-2.41.1
Distance traveled before self-admin0.80.81.40.5-1.2
Distance traveled after self-admin0.10.10.1-0.2-0.4
Extensor digitorum longus weight0.62.23.01.7-1.2
Bone: elastic displacement0.30.40.50.5-0.7
Bone: elastic work4.96.38.02.8-2.1
Bone: endosteal estimation0.81.83.21.8-0.6
Bone: endosteal perimeter0.91.83.11.8-0.7
Epididymis fat weight12.228.449.77.1-2.7
Delta time in closed arm before/after self-admin0.20.20.4-0.0-0.6
Delta time in open arm before/after self-admin2.72.63.9-1.22.0
Diff in mean of infusions in LGA sessions0.30.30.60.20.8
Delay discount exponential model param0.20.20.4-0.6-0.2
Extinction: sum of active levers before priming0.70.71.0-0.61.0
Active lever presses in extinction session 61.81.83.21.8-0.6
Bone: final force5.08.110.83.3-2.3
Bone: final moment5.38.612.23.5-2.2
Food consumed during 24 hour testing period0.20.30.30.5-0.5
Glucose0.71.12.01.40.5
Heart weight4.25.910.83.3-1.0
Delay discount hyperbolic model param0.20.20.5-0.7-0.1
Intermittent access intake day 1-15 change0.00.00.10.10.3
Intermittent access intake escalation0.10.10.10.2-0.4
Intermittent access intake escalation 20.00.00.10.3-0.1
Intermitt. access day 1 inactive lever presses0.20.20.40.6-0.1
Intermitt. access day 15 inactive lever presses1.71.92.71.6-1.1
Intermitt. access escalation Index0.00.00.0-0.20.1
Intermittent access day 1 total infusions0.30.30.5-0.70.4
Intermittent access day 15 total infusions0.10.10.1-0.30.0
Intermittent access terminal intake (last 3 days)0.10.10.1-0.30.1
Intermittent access total infusions0.50.61.0-1.00.4
Intermittent access day 1 locomotion0.70.71.4-1.2-0.1
Intermittent access day 15 total locomotion0.20.20.3-0.20.5
Intermittent access total locomotion0.30.30.6-0.8-0.0
Intermittent access standard deviation1.11.21.4-1.01.2
Left kidney weight9.626.931.65.6-4.7
Right kidney weight9.727.329.85.5-5.0
Cocaine induced anxiety1.51.73.2-1.80.5
Post-drug Anxiety0.91.01.3-1.20.8
Baseline Anxiety0.30.30.30.60.5
Tail length0.10.40.70.90.3
Length with tail1.14.17.52.7-0.9
Length without tail2.14.77.12.7-1.5
Times rat made contact with spout0.91.01.81.3-0.5
Lifetime Intake0.40.50.9-1.00.3
Liver weight, left2.23.56.72.6-0.6
Liver weight, right2.33.86.82.6-0.8
Locomotor activity0.10.10.2-0.20.4
Locomotor testing distance0.10.10.20.4-0.2
Locomotor testing rearing0.20.30.40.6-0.5
Locomotion in novel chamber2.83.43.71.8-1.9
Locomotion in novel chamber post-restriction2.63.23.81.6-1.9
Fecal boli incidents, locomotor time 10.60.61.0-0.41.0
Change in fecal boli incidents, locomotor task0.50.50.60.8-0.6
Time >=10cm from walls, locomotor time 10.40.40.5-0.70.5
Bouts of movement, locomotor time 10.10.10.2-0.00.5
Total resting periods, locomotor time 10.00.00.00.20.1
Rest time, locomotor task time 11.92.13.21.0-1.8
Distance moved, locomotor task time 10.10.10.20.00.5
Vertical activity count, locomotor time 10.00.00.1-0.00.2
Time >=10cm from walls, locomotor time 20.40.40.50.6-0.7
Bouts of movement, locomotor time 20.00.00.1-0.30.0
Total resting periods, locomotor time 20.00.00.1-0.30.0
Rest time, locomotor task time 20.00.00.1-0.2-0.1
Distance moved, locomotor task time 20.30.30.40.7-0.5
Vertical activity count, locomotor time 20.00.00.00.1-0.2
Light reinforcement 10.81.41.71.0-1.3
Light reinforcement 20.20.30.3-0.60.4
Bone: marrow area0.92.03.51.9-0.7
Bone: maximum diameter1.32.44.82.2-0.2
Bone: maximum force4.68.010.93.3-2.3
Bone: maximum moment4.88.312.03.5-2.1
Mean time between licks in bursts1.62.22.7-1.31.6
Mean num. licks in bursts2.73.33.41.8-1.8
Cd content in liver0.80.91.6-1.30.4
Co content in liver0.91.01.50.7-1.2
Cu content in liver0.20.20.40.6-0.3
Fe content in liver0.50.51.1-1.00.2
K content in liver0.10.10.2-0.1-0.4
Mg content in liver0.20.20.40.1-0.6
Mn content in liver1.11.21.41.2-1.0
Na content in liver0.20.20.20.5-0.3
Rb content in liver0.40.50.9-1.00.2
Se content in liver0.81.01.9-1.40.1
Sr content in liver0.60.60.7-0.7-0.8
Zn content in liver1.92.14.10.5-2.0
Bone: minimum diameter2.03.76.72.6-0.8
Time in familiar zone, hab. session 10.70.71.21.1-0.4
Time in novel zone, hab. session 14.14.04.6-2.21.8
Total zone transitions, hab. session 10.40.60.60.7-0.8
Total locomotion distance, hab. session 10.40.50.5-0.70.7
Locomotion velocity, hab. session 10.20.20.3-0.60.3
Time in familiar zone, hab. session 22.52.54.3-0.92.1
Time in novel zone, hab. session 20.80.81.40.4-1.2
Total zone transitions, hab. session 20.50.60.70.8-0.7
Total locomotion distance, hab. session 20.10.10.20.4-0.1
Locomotion velocity, hab. session 20.20.20.40.6-0.3
Novel to familiar place preference ratio1.11.21.2-1.11.1
Novelty place preference1.21.31.4-1.21.0
Time in novel zone, NPP test2.42.52.8-1.51.7
Total zone transitions, NPP test1.31.81.91.3-1.4
Total locomotion distance, NPP test0.30.50.60.6-0.8
Locomotion velocity, NPP test1.52.13.01.1-1.7
Intraocular pressure0.91.32.40.31.6
Delta distance traveled before/after self-admin0.50.50.7-0.80.6
Delta ambulatory time before/after self-admin0.40.40.6-0.80.6
Parametrial fat weight8.115.727.35.2-2.0
Pavlov. Cond. lever latency1.31.72.5-1.60.9
Pavlov. Cond. magazine entry latency0.60.71.41.2-0.3
Pavlov. Cond. change in total contacts0.50.51.01.00.3
Pavlov. Cond. index score0.70.91.61.3-0.4
Pavlov. Cond. latency score0.70.91.61.3-0.3
Pavlov. Cond. lever contacts0.91.01.91.4-0.3
Pavlov. Cond. magazine entry number0.20.30.6-0.80.1
Pavlov. Cond. intertrial magazine entries1.82.22.71.6-1.3
Pavlov. Cond. lever-magazine prob. diff.0.60.81.51.2-0.2
Pavlov. Cond. response bias0.81.01.71.3-0.5
Pavlov. Cond. lever latency0.10.10.2-0.1-0.5
Pavlov. Cond. magazine entry latency1.01.21.8-0.81.3
Pavlov. Cond. change in total contacts0.20.30.4-0.50.7
Pavlov. Cond. index score0.20.30.5-0.30.7
Pavlov. Cond. latency score0.20.20.3-0.30.5
Pavlov. Cond. lever contacts0.10.10.20.10.4
Pavlov. Cond. magazine entry number0.20.20.30.4-0.6
Pavlov. Cond. intertrial magazine entries3.64.75.92.4-1.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.40.7
Pavlov. Cond. response bias0.60.81.4-0.51.2
Time in closed arm before self-admin0.10.10.2-0.20.5
Time in closed arm after self-admin0.00.00.1-0.1-0.3
Time in open arm before self-admin0.30.30.5-0.70.3
Time in open arm after self-admin2.83.14.0-1.52.0
Bone: periosteal estimation3.57.211.33.4-1.7
Bone: periosteal perimeter3.66.010.13.2-1.4
Bone: post-yield work0.00.00.00.2-0.1
Progressive ratio test 1 active lever presses0.20.20.4-0.6-0.0
Progressive ratio test 1 breakpoint0.10.10.3-0.50.0
Progressive ratio test 1 inactive lever presses0.20.20.4-0.70.1
Progressive ratio test 2 active lever presses0.50.50.60.8-0.6
Progressive ratio test 2 breakpoint0.60.60.80.9-0.7
Progressive ratio test 2 inactive lever presses0.00.00.0-0.1-0.1
Incentive Sensitization - Responses1.21.22.01.4-0.6
Incentive Sensitization - Breakpoint0.80.91.51.2-0.5
Sum of active levers in priming session hrs 5-60.20.20.2-0.30.5
Progressive ratio0.80.91.7-1.30.2
Food seeking constrained by brief footshock3.64.46.0-2.41.7
Seeking ratio, punishment vs. effort0.00.00.0-0.00.2
Retroperitoneal fat weight15.651.284.99.2-4.2
Reaction time number correct0.10.10.10.30.3
Reaction time mean minus median0.50.71.31.1-0.3
Reaction time mean minus median AUC1.31.72.51.6-0.9
Reaction time num false alarms1.01.31.51.2-1.1
Reaction time num false alarms AUC1.72.33.31.8-1.2
Reaction time trials correct on left0.10.10.10.30.3
Reaction time trials on left0.10.10.10.30.3
Reaction time mean0.20.30.3-0.60.6
Reaction time mean AUC0.20.20.3-0.50.4
Median of all reaction times0.40.50.7-0.80.6
Reaction time omissions0.50.71.0-0.71.0
Reaction time false alarm rate1.01.41.91.4-1.0
Reaction time premature initiation rate0.60.91.21.1-0.7
Reaction time premature initiations0.81.11.81.3-0.7
Std. dev. reaction times0.30.40.80.9-0.0
Reaction time trials completed0.10.10.10.30.3
Reaction time trials AUC0.10.10.20.50.2
Run reversals in cocaine runway, females0.60.60.7-0.80.7
Run reversals in cocaine runway, males1.11.11.70.7-1.3
Latency to leave start box in cocaine runway2.42.53.0-1.41.7
Latency to leave start box in cocaine runway, F0.80.81.1-0.81.1
Latency to leave start box in cocaine runway, M0.80.80.9-0.81.0
Std. dev. time between licks in bursts1.51.82.4-1.51.1
Total sessions with >9 infusions0.40.51.0-0.0-1.0
Short access day 1 total inactive lever presses0.50.60.9-1.00.5
Short access day 10 total inactive lever presses3.23.63.61.9-1.9
Short access day 1 total infusions0.30.30.5-0.7-0.3
Short access day 10 total infusions1.01.11.7-1.30.7
Short access total infusions0.30.30.6-0.8-0.1
Short access day 1 locomotion0.10.10.1-0.3-0.2
Short access day 10 total locomotion0.30.30.6-0.80.1
Short access total locomotion0.60.61.1-0.4-1.0
One hour access (0.3 mA shock)0.80.91.2-0.81.1
Compulsive drug intake0.00.00.00.10.1
One hour access (shock baseline)0.60.60.9-1.00.6
Social response proportion0.30.30.40.5-0.6
Social responses0.30.40.80.9-0.2
Social time0.20.20.40.60.2
Soleus weight3.610.512.53.5-2.9
Bone: stiffness2.13.23.92.0-1.6
Tibialis anterior weight0.00.00.10.0-0.3
Time to tail flick, vehicle, before self-admin0.20.20.3-0.50.4
Time to tail flick, vehicle, after self-admin0.20.30.30.6-0.4
Time to tail flick, test, before self-admin0.40.30.70.1-0.8
Time to tail flick, test, after self-admin0.20.20.3-0.30.6
Delta time to tail flick, vehicle, before/after SA1.61.62.71.6-0.7
Delta time to tail flick, test, before/after SA0.30.30.5-0.10.7
Tibia length0.20.71.21.1-0.4
Ambulatory time before self-admin0.70.71.00.6-1.0
Ambulatory time after self-admin0.10.10.3-0.5-0.1
Bone: tissue strength1.31.31.3-1.11.1
Total heroin consumption2.12.54.92.2-0.4
Bone: trabecular number0.40.71.31.1-0.1
Bone: trabecular spacing3.24.25.7-2.41.7
Bone: trabecular thickness6.07.212.13.5-1.5
Bone: trabecular tissue density0.60.91.6-1.30.3
Water consumed over 24 hours0.50.60.80.6-0.9
Number of responses in last shaping day0.40.40.8-0.90.3