Hub : Genes

Hadha

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg mRNA stability Hadha 0.17 0.15 3.6e-03 0.05 0.02 0.02 0.03 1.7e-02 7.3e-02 8.0e-02 6.3e-02
2 Adipose gene expression Hadha 0.13 0.1 8.4e-13 0.1 0.1 0.07 0.1 9.0e-11 1.1e-10 9.7e-09 1.0e-10
3 NAcc gene expression Hadha 0.02 0.02 7.3e-03 0.02 0.02 0.01 0.02 3.9e-03 4.1e-03 6.0e-03 3.7e-03
4 PL gene expression Hadha 0.04 0.04 8.6e-05 0.02 0.03 0.02 0.02 1.1e-03 5.9e-04 2.3e-03 2.5e-03
5 Liver mRNA stability Hadha 0.05 0.04 6.0e-05 0.04 0.04 0.03 0.04 5.6e-05 4.3e-05 1.4e-04 6.1e-05
6 pVTA gene expression Hadha 0.07 0.07 9.8e-03 0.05 0.03 0.03 0.04 2.5e-03 2.1e-02 1.7e-02 5.7e-03
7 Liver gene expression Hadha 0.12 0.1 6.3e-10 0.08 0.08 0.08 0.08 3.2e-09 5.0e-09 2.8e-09 5.0e-09
8 Brain gene expression Hadha 0.07 0.06 3.8e-06 0.07 0.06 0.06 0.06 9.9e-07 2.1e-06 2.7e-06 2.8e-06
9 Brain mRNA stability Hadha 0.08 0.07 6.7e-07 0.07 0.07 0.07 0.07 2.6e-07 4.8e-07 3.6e-07 2.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.94.95.9-2.42.2-2.2-2.22.22.12.22.1-2.3
Area under the delay curve0.00.00.1-0.0-0.10.10.2-0.20.00.1-0.4-0.0
BMI with tail2.58.28.62.9-2.92.82.9-2.9-2.8-2.9-2.92.6
BMI without tail0.40.91.11.0-1.01.01.0-1.0-0.7-0.8-1.10.5
Body weight2.29.011.22.9-2.92.93.0-2.9-3.3-3.2-2.92.9
Weight adjusted by age0.30.41.01.0-0.50.50.6-0.60.0-0.4-0.60.9
Bone surface0.50.91.1-1.01.0-1.0-0.91.00.80.80.9-1.0
Bone volume1.52.53.1-1.71.6-1.7-1.61.61.51.41.6-1.6
Breakpoint value in progressive ratio session0.91.01.3-1.11.1-1.1-1.11.10.31.01.0-1.1
Number of licking bursts1.31.51.81.3-1.21.21.3-1.2-1.2-1.2-1.21.2
Context. condit. distance diff. score0.20.20.3-0.60.5-0.5-0.50.50.50.30.6-0.3
Locomotion velocity, session 10.91.01.81.1-0.90.90.9-0.9-1.4-1.1-0.91.0
Locomotion distance, session 10.20.20.4-0.30.6-0.6-0.60.60.20.20.6-0.1
Locomotion velocity, session 20.00.00.10.1-0.10.10.2-0.2-0.2-0.4-0.10.3
Locomotion distance, session 20.20.20.60.5-0.40.40.3-0.3-0.4-0.7-0.30.8
Locomotion velocity, session 30.10.10.6-0.20.1-0.2-0.20.20.80.30.2-0.1
Locomotion distance, session 30.10.10.20.1-0.20.20.2-0.20.1-0.4-0.20.4
Stereotopy head waving bouts, day 32.32.74.5-1.31.6-1.6-1.61.62.11.71.6-1.6
Stereotopy head waving duration, day 30.70.81.3-0.60.9-0.9-0.80.81.10.90.9-0.9
Locomotion velocity, session 70.00.00.30.1-0.10.10.1-0.10.50.1-0.10.1
Locomotion distance, session 71.01.21.71.1-1.11.01.1-1.1-1.0-1.3-1.11.2
Stereotopy head waving bouts, day 70.00.00.40.20.00.0-0.00.00.60.20.00.0
Stereotopy head waving duration, day 70.60.71.7-0.60.7-0.7-0.70.71.31.00.7-0.8
Locomotion velocity, session 80.50.60.7-0.80.8-0.7-0.80.80.80.80.8-0.8
Locomotion distance, session 80.20.30.6-0.50.6-0.6-0.60.60.80.40.7-0.3
Degree of sensitization distance0.90.91.30.9-0.90.90.9-0.9-1.2-1.0-0.90.8
Degree of sensitization stereotypy0.30.30.40.6-0.60.60.5-0.5-0.0-0.4-0.50.6
Conditioned locomotion3.94.65.8-2.02.0-2.1-2.12.12.32.32.0-2.4
Cocaine response after cond. corrected0.20.20.3-0.50.4-0.4-0.40.40.40.40.4-0.5
Cocaine response after cond. not corrected0.80.91.1-0.90.9-0.9-0.90.91.01.00.9-1.1
Cocaine response before conditioning2.32.83.4-1.51.6-1.6-1.61.61.71.81.7-1.8
Saline control response1.31.72.3-1.51.5-1.5-1.41.41.01.01.4-1.0
Bone: connectivity density1.72.73.9-2.01.7-1.7-1.71.71.31.51.6-1.7
Bone: cortical apparent density0.00.00.2-0.30.0-0.0-0.10.10.00.30.1-0.4
Bone: cortical area0.10.10.3-0.1-0.20.20.3-0.2-0.5-0.5-0.20.5
Bone: cortical porosity3.74.05.4-1.92.0-2.0-2.02.02.32.12.0-1.8
Bone: cortical porosity2.93.14.1-1.81.7-1.8-1.71.72.01.91.7-1.7
Bone: cortical thickness0.20.40.60.3-0.60.60.7-0.7-0.6-0.7-0.70.7
Bone: cortical thickness0.40.50.7-0.90.7-0.7-0.70.70.70.70.7-0.6
Bone: cortical tissue density0.00.00.1-0.2-0.00.1-0.00.0-0.10.20.0-0.3
Condit. Reinf. active minus inactive responses2.02.22.41.4-1.51.61.5-1.5-1.5-1.5-1.51.4
Condit. Reinf. active-inactive response ratio1.51.71.91.2-1.31.41.4-1.4-1.3-1.2-1.31.1
Condit. Reinf. active responses0.10.20.20.4-0.40.50.4-0.4-0.4-0.5-0.40.3
Condit. Reinf. inactive responses0.91.01.2-0.91.1-1.0-1.11.11.10.81.1-0.8
Incentive salience index mean0.20.30.40.5-0.50.50.5-0.5-0.6-0.6-0.50.5
Condit. Reinf. lever presses0.40.60.7-0.80.8-0.9-0.80.80.70.50.8-0.6
Condit. Reinf. active minus inactive responses1.41.83.5-1.01.2-1.2-1.31.21.91.41.2-1.3
Condit. Reinf. active-inactive response ratio0.70.71.0-0.70.8-0.8-0.80.81.00.90.8-0.9
Condit. Reinf. active responses0.91.33.5-0.70.9-0.9-1.01.01.91.21.0-1.2
Condit. Reinf. inactive responses0.30.31.3-0.30.4-0.4-0.40.41.20.60.5-0.6
Condit. Reinf. lever presses1.21.63.5-0.81.1-1.2-1.21.21.91.41.1-1.3
Condit. Reinf. lever reinforcers received0.81.13.3-0.70.8-0.9-0.90.91.81.20.9-1.1
Conditioned reinforcement - actives4.34.36.3-2.51.9-1.9-2.02.01.82.21.9-2.2
Conditioned reinforcement - inactives5.15.86.8-2.62.6-2.6-2.52.51.72.22.4-2.5
Conditioned locomotion3.74.45.2-2.32.1-2.1-2.12.12.02.22.0-2.0
Patch foraging indifference point 0 sec0.71.12.11.0-0.80.91.0-0.9-0.8-1.5-0.91.3
Patch foraging indifference point AUC0.00.00.0-0.2-0.2-0.00.00.00.00.20.2-0.2
Delay disc. indifference point, 0s delay1.21.32.01.1-1.01.01.1-1.1-1.4-1.1-1.21.3
Delay disc. indifference point, 16s delay0.10.10.10.3-0.20.20.3-0.30.3-0.1-0.30.1
Delay disc. indifference point, 2s delay0.10.10.10.3-0.30.30.3-0.3-0.1-0.2-0.40.4
Delay disc. indifference point, 24s delay2.62.52.8-1.51.7-1.7-1.61.61.51.61.4-1.6
Delay disc. indifference point, 4s delay0.20.20.40.3-0.40.40.5-0.5-0.5-0.3-0.60.3
Delay disc. indifference point, 8s delay0.10.10.1-0.30.1-0.1-0.10.10.40.4-0.1-0.3
Indifference point function ln k1.42.02.4-1.31.6-1.4-1.51.51.41.31.4-1.4
Indifference point function log k1.42.02.4-1.31.6-1.4-1.51.51.41.31.4-1.4
Patch foraging total patch changes 0 sec0.71.12.31.0-0.80.91.0-0.9-1.0-1.5-0.81.3
Patch foraging total patch changes 12 sec1.11.42.31.1-1.21.11.2-1.1-1.2-1.5-1.01.3
Patch foraging total patch changes 18 sec1.01.32.01.0-1.21.21.1-1.1-1.0-1.4-1.01.2
Patch foraging total patch changes 24 sec1.31.62.11.3-1.31.21.2-1.2-1.1-1.5-1.21.3
Patch foraging total patch changes 6 sec1.82.62.91.6-1.61.71.7-1.7-1.3-1.7-1.61.7
Patch foraging time to switch 0 sec0.20.40.70.8-0.60.60.6-0.6-0.5-0.5-0.70.5
Patch foraging water rate 0 sec0.91.52.0-1.31.3-1.3-1.31.31.10.91.4-0.8
Patch foraging water rate 12 sec0.10.10.20.2-0.30.30.3-0.3-0.2-0.4-0.30.5
Patch foraging water rate 18 sec1.01.31.8-1.31.2-1.1-1.21.21.10.81.3-0.9
Patch foraging water rate 24 sec0.10.20.40.0-0.40.40.3-0.3-0.6-0.6-0.30.5
Patch foraging water rate 6 sec0.10.10.2-0.20.4-0.4-0.40.40.20.30.4-0.2
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.0-0.00.00.1-0.1-0.0-0.1-0.00.2
Distance traveled before self-admin0.30.31.0-0.60.1-0.1-0.40.31.00.70.2-0.6
Distance traveled after self-admin0.30.30.60.4-0.60.60.5-0.5-0.4-0.7-0.60.7
Extensor digitorum longus weight2.18.410.6-3.32.9-2.7-2.92.83.12.82.8-2.7
Bone: elastic displacement1.82.12.9-1.71.3-1.3-1.31.31.41.71.3-1.6
Bone: elastic work0.60.71.2-1.00.8-0.7-0.70.70.91.10.8-0.9
Bone: endosteal estimation0.00.10.2-0.20.4-0.4-0.30.4-0.2-0.10.4-0.1
Bone: endosteal perimeter0.00.00.10.10.1-0.00.00.0-0.3-0.30.10.2
Epididymis fat weight15.135.240.25.8-6.36.26.1-6.2-5.3-5.5-6.25.7
Delta time in closed arm before/after self-admin0.50.51.50.6-0.40.40.5-0.5-1.2-0.9-0.40.9
Delta time in open arm before/after self-admin0.10.10.3-0.50.1-0.1-0.20.20.20.20.1-0.2
Diff in mean of infusions in LGA sessions0.00.00.1-0.10.2-0.2-0.20.2-0.20.20.2-0.3
Delay discount exponential model param0.00.00.10.2-0.10.10.0-0.0-0.3-0.30.10.3
Extinction: sum of active levers before priming0.40.40.7-0.80.8-0.8-0.70.7-0.40.20.7-0.4
Active lever presses in extinction session 61.71.62.0-1.41.4-1.4-1.31.30.71.11.3-1.3
Bone: final force0.00.00.2-0.2-0.10.10.1-0.1-0.4-0.2-0.10.2
Bone: final moment0.00.00.2-0.2-0.10.10.1-0.1-0.4-0.2-0.10.2
Food consumed during 24 hour testing period0.10.10.30.6-0.20.20.3-0.3-0.0-0.3-0.30.2
Glucose0.20.30.40.6-0.60.60.6-0.6-0.7-0.4-0.60.4
Heart weight4.66.57.32.2-2.72.62.5-2.6-2.7-2.5-2.62.5
Delay discount hyperbolic model param0.00.00.00.2-0.00.0-0.00.1-0.2-0.20.20.2
Intermittent access intake day 1-15 change1.61.61.9-1.31.3-1.3-1.41.40.81.21.4-1.3
Intermittent access intake escalation0.80.81.0-0.90.9-0.9-1.01.00.40.81.0-1.0
Intermittent access intake escalation 20.10.10.20.1-0.20.20.2-0.2-0.5-0.4-0.20.3
Intermitt. access day 1 inactive lever presses0.10.10.2-0.50.2-0.1-0.20.20.40.20.1-0.3
Intermitt. access day 15 inactive lever presses1.92.03.5-1.21.5-1.5-1.31.31.91.41.3-1.4
Intermitt. access escalation Index3.43.04.42.1-1.71.71.6-1.6-1.7-1.8-1.51.7
Intermittent access day 1 total infusions4.14.86.4-2.32.2-2.1-2.12.12.52.32.0-2.0
Intermittent access day 15 total infusions4.24.75.9-2.42.2-2.2-2.22.21.92.02.2-2.0
Intermittent access terminal intake (last 3 days)3.74.14.6-2.12.1-2.0-2.02.01.82.12.0-1.9
Intermittent access total infusions5.25.87.1-2.72.5-2.4-2.42.42.12.42.4-2.3
Intermittent access day 1 locomotion2.22.32.7-1.61.6-1.6-1.61.61.31.51.5-1.2
Intermittent access day 15 total locomotion0.50.50.9-1.00.6-0.7-0.70.70.61.00.6-0.6
Intermittent access total locomotion0.91.01.7-1.31.0-1.1-1.11.00.61.11.0-0.8
Intermittent access standard deviation0.70.71.9-1.40.8-0.9-0.90.80.70.50.8-0.4
Left kidney weight0.51.32.8-1.71.1-1.2-1.21.20.70.81.3-0.9
Right kidney weight0.10.41.0-0.1-0.60.60.5-0.5-1.0-0.9-0.40.7
Cocaine induced anxiety0.10.10.1-0.20.2-0.2-0.20.2-0.20.40.2-0.3
Post-drug Anxiety1.41.62.41.0-1.21.21.3-1.2-1.5-1.2-1.21.2
Baseline Anxiety1.31.41.81.2-1.21.21.2-1.2-0.7-1.3-1.21.3
Tail length0.20.50.6-0.70.7-0.6-0.70.70.60.70.7-0.7
Length with tail0.10.51.50.5-0.40.60.5-0.5-1.2-1.0-0.41.0
Length without tail0.30.61.90.4-0.40.50.4-0.4-1.4-1.1-0.31.1
Times rat made contact with spout0.60.71.6-0.70.8-0.8-0.80.81.30.90.7-0.7
Lifetime Intake5.96.78.2-2.92.6-2.6-2.62.62.32.62.6-2.5
Liver weight, left1.11.72.21.3-1.51.41.3-1.3-1.4-1.2-1.31.1
Liver weight, right6.110.212.93.2-3.13.13.1-3.1-3.6-3.4-3.13.1
Locomotor activity0.71.22.31.0-1.00.90.9-0.9-1.5-1.4-0.91.0
Locomotor testing distance0.40.70.90.9-0.90.80.7-0.8-0.7-1.0-0.80.6
Locomotor testing rearing0.30.40.6-0.60.7-0.8-0.80.80.60.20.8-0.5
Locomotion in novel chamber0.40.50.70.7-0.70.70.7-0.7-0.8-0.8-0.80.5
Locomotion in novel chamber post-restriction3.44.16.72.0-1.81.91.9-1.8-2.6-2.2-1.82.1
Fecal boli incidents, locomotor time 12.62.93.7-1.91.8-1.8-1.81.81.31.21.8-1.6
Change in fecal boli incidents, locomotor task3.53.34.31.8-1.81.81.8-1.8-2.1-1.9-1.81.8
Time >=10cm from walls, locomotor time 10.40.40.7-0.60.7-0.7-0.60.70.20.50.7-0.8
Bouts of movement, locomotor time 10.20.21.50.00.1-0.1-0.00.01.20.20.10.0
Total resting periods, locomotor time 10.20.22.00.10.1-0.1-0.10.11.40.20.1-0.1
Rest time, locomotor task time 10.10.11.00.00.1-0.1-0.10.11.00.30.1-0.2
Distance moved, locomotor task time 10.30.41.70.6-0.40.40.4-0.4-1.3-0.5-0.40.4
Vertical activity count, locomotor time 10.30.31.10.5-0.50.50.5-0.5-1.0-0.4-0.50.4
Time >=10cm from walls, locomotor time 21.71.71.9-1.31.3-1.3-1.31.31.21.41.3-1.3
Bouts of movement, locomotor time 20.60.61.01.0-0.80.80.8-0.8-0.2-0.8-0.80.8
Total resting periods, locomotor time 20.70.71.21.1-0.90.90.9-0.9-0.1-0.8-0.90.9
Rest time, locomotor task time 20.10.11.20.3-0.10.10.1-0.01.10.1-0.10.0
Distance moved, locomotor task time 20.10.10.6-0.00.3-0.3-0.20.2-0.80.20.3-0.3
Vertical activity count, locomotor time 20.30.40.4-0.50.7-0.7-0.60.6-0.00.70.7-0.6
Light reinforcement 10.40.82.0-0.61.1-1.0-0.90.91.40.31.0-0.3
Light reinforcement 21.11.52.4-0.91.2-1.2-1.21.31.61.11.3-1.0
Bone: marrow area0.00.10.2-0.20.4-0.4-0.40.4-0.1-0.10.4-0.2
Bone: maximum diameter0.00.00.1-0.10.1-0.00.00.0-0.2-0.20.00.3
Bone: maximum force0.00.00.2-0.1-0.10.10.2-0.1-0.5-0.3-0.10.2
Bone: maximum moment0.00.00.1-0.20.00.00.1-0.1-0.4-0.2-0.00.1
Mean time between licks in bursts1.82.53.21.8-1.61.51.6-1.6-1.8-1.5-1.61.4
Mean num. licks in bursts1.61.92.5-1.41.4-1.3-1.41.41.61.41.3-1.3
Cd content in liver0.40.50.80.6-0.50.50.6-0.6-0.8-0.9-0.50.9
Co content in liver5.36.27.6-2.22.4-2.4-2.42.42.72.72.4-2.5
Cu content in liver0.10.10.1-0.30.3-0.3-0.30.3-0.3-0.10.3-0.3
Fe content in liver0.10.10.2-0.30.4-0.3-0.30.4-0.4-0.20.40.1
K content in liver2.22.22.91.7-1.31.31.4-1.3-1.6-1.7-1.31.5
Mg content in liver2.22.33.91.4-1.21.21.4-1.3-2.0-1.9-1.21.8
Mn content in liver0.20.30.60.4-0.50.50.5-0.5-0.4-0.4-0.50.8
Na content in liver1.61.72.1-1.21.4-1.5-1.41.41.01.01.4-1.2
Rb content in liver0.70.81.61.0-0.60.60.8-0.7-1.3-1.2-0.61.1
Se content in liver1.21.53.01.1-1.01.01.1-1.0-1.7-1.5-1.01.4
Sr content in liver0.00.00.10.4-0.20.20.2-0.20.1-0.0-0.2-0.1
Zn content in liver1.82.03.01.6-1.21.11.3-1.3-1.7-1.7-1.21.6
Bone: minimum diameter0.61.12.10.6-0.80.91.0-0.9-1.4-1.5-0.91.4
Time in familiar zone, hab. session 11.00.92.20.8-0.80.80.9-0.9-1.5-1.1-0.80.9
Time in novel zone, hab. session 10.20.20.30.5-0.50.50.5-0.50.0-0.3-0.50.5
Total zone transitions, hab. session 10.10.10.2-0.50.4-0.3-0.40.40.30.30.4-0.3
Total locomotion distance, hab. session 10.71.01.7-1.01.0-0.9-1.01.01.31.01.0-1.0
Locomotion velocity, hab. session 11.42.13.1-1.41.3-1.3-1.41.41.81.51.4-1.5
Time in familiar zone, hab. session 20.30.30.40.5-0.50.50.6-0.5-0.5-0.6-0.50.6
Time in novel zone, hab. session 20.00.00.10.1-0.10.10.1-0.1-0.3-0.1-0.20.1
Total zone transitions, hab. session 20.30.40.80.7-0.60.60.5-0.6-0.5-0.9-0.50.9
Total locomotion distance, hab. session 20.20.30.40.7-0.60.50.6-0.6-0.1-0.6-0.50.6
Locomotion velocity, hab. session 20.10.20.20.5-0.40.40.4-0.40.0-0.4-0.40.5
Novel to familiar place preference ratio0.50.50.90.9-0.70.60.7-0.7-0.2-0.7-0.70.9
Novelty place preference0.80.91.31.1-0.90.90.9-0.9-0.5-0.9-0.91.2
Time in novel zone, NPP test0.80.81.31.1-0.80.80.8-0.8-0.5-0.9-0.91.1
Total zone transitions, NPP test0.50.81.1-0.81.0-1.0-1.01.00.70.71.0-0.6
Total locomotion distance, NPP test1.01.41.6-0.91.2-1.3-1.31.31.21.01.3-1.0
Locomotion velocity, NPP test1.42.02.2-1.21.5-1.5-1.51.51.51.31.5-1.2
Intraocular pressure5.06.910.02.4-2.52.52.5-2.5-3.2-2.9-2.52.7
Delta distance traveled before/after self-admin1.92.02.51.6-1.31.31.4-1.3-1.5-1.5-1.31.6
Delta ambulatory time before/after self-admin0.50.50.90.9-0.50.50.6-0.6-0.8-0.8-0.60.9
Parametrial fat weight9.117.719.44.2-4.44.44.4-4.3-3.6-4.1-4.34.1
Pavlov. Cond. lever latency0.30.40.60.7-0.70.70.7-0.7-0.5-0.4-0.70.5
Pavlov. Cond. magazine entry latency0.10.10.30.3-0.20.20.3-0.3-0.3-0.6-0.30.4
Pavlov. Cond. change in total contacts0.00.00.1-0.00.2-0.2-0.20.20.0-0.20.20.1
Pavlov. Cond. index score0.00.00.1-0.20.2-0.2-0.20.20.1-0.30.20.0
Pavlov. Cond. latency score0.00.00.2-0.10.0-0.1-0.00.0-0.1-0.40.00.2
Pavlov. Cond. lever contacts0.30.30.5-0.50.6-0.7-0.60.70.50.30.6-0.5
Pavlov. Cond. magazine entry number0.00.00.1-0.10.0-0.0-0.00.0-0.00.30.0-0.1
Pavlov. Cond. intertrial magazine entries2.22.73.2-1.61.6-1.5-1.61.61.51.81.6-1.8
Pavlov. Cond. lever-magazine prob. diff.0.30.30.5-0.60.6-0.7-0.60.60.60.20.6-0.5
Pavlov. Cond. response bias0.81.01.1-0.91.0-1.0-1.01.01.10.71.0-0.9
Pavlov. Cond. lever latency1.01.32.80.8-0.91.01.0-1.0-1.7-1.3-1.01.3
Pavlov. Cond. magazine entry latency0.00.00.20.4-0.20.10.1-0.10.20.1-0.2-0.1
Pavlov. Cond. change in total contacts0.10.10.7-0.1-0.1-0.1-0.20.10.80.60.1-0.5
Pavlov. Cond. index score0.40.51.3-0.30.5-0.6-0.60.61.10.90.5-0.9
Pavlov. Cond. latency score0.40.51.2-0.30.5-0.6-0.60.61.10.90.6-0.9
Pavlov. Cond. lever contacts0.30.41.3-0.30.4-0.5-0.60.51.10.80.5-0.8
Pavlov. Cond. magazine entry number0.10.10.3-0.50.4-0.3-0.30.3-0.10.10.40.0
Pavlov. Cond. intertrial magazine entries2.63.34.01.7-1.71.81.8-1.8-1.9-1.9-1.82.0
Pavlov. Cond. lever-magazine prob. diff.0.10.20.7-0.00.2-0.3-0.30.30.80.60.2-0.6
Pavlov. Cond. response bias0.50.71.8-0.50.5-0.7-0.70.71.31.10.6-1.1
Time in closed arm before self-admin0.20.20.30.4-0.60.60.4-0.4-0.5-0.5-0.50.4
Time in closed arm after self-admin0.80.91.70.8-0.90.90.8-0.9-1.3-1.0-0.90.7
Time in open arm before self-admin0.00.00.10.20.1-0.10.1-0.1-0.10.00.00.3
Time in open arm after self-admin0.30.30.5-0.70.5-0.5-0.50.50.60.60.5-0.4
Bone: periosteal estimation0.10.10.3-0.50.5-0.4-0.30.4-0.1-0.10.4-0.1
Bone: periosteal perimeter0.00.00.10.1-0.00.00.1-0.1-0.4-0.4-0.00.4
Bone: post-yield work1.82.42.8-1.71.6-1.6-1.61.61.11.41.7-1.6
Progressive ratio test 1 active lever presses3.23.44.4-2.11.9-1.8-1.81.81.62.01.8-1.7
Progressive ratio test 1 breakpoint2.52.63.6-1.91.6-1.5-1.61.61.51.71.6-1.5
Progressive ratio test 1 inactive lever presses5.86.37.3-2.52.5-2.4-2.42.42.72.52.4-2.7
Progressive ratio test 2 active lever presses2.22.33.1-1.71.8-1.7-1.61.61.01.31.6-1.2
Progressive ratio test 2 breakpoint2.32.53.3-1.81.8-1.8-1.61.71.11.41.7-1.3
Progressive ratio test 2 inactive lever presses3.13.64.4-1.92.1-2.1-1.91.91.71.81.9-1.7
Incentive Sensitization - Responses1.21.22.2-1.01.5-1.5-1.21.30.20.61.4-0.8
Incentive Sensitization - Breakpoint0.80.81.5-0.81.2-1.2-1.01.00.10.41.1-0.5
Sum of active levers in priming session hrs 5-60.20.20.50.6-0.20.20.4-0.3-0.7-0.6-0.30.6
Progressive ratio0.20.20.3-0.20.5-0.5-0.40.50.40.50.5-0.3
Food seeking constrained by brief footshock13.516.620.2-4.24.5-4.5-4.34.42.93.64.5-3.5
Seeking ratio, punishment vs. effort1.31.62.7-1.61.3-1.3-1.41.30.81.01.4-1.1
Retroperitoneal fat weight28.693.8102.89.6-10.110.110.0-10.0-8.7-9.2-9.99.5
Reaction time number correct0.20.30.8-0.80.3-0.3-0.40.40.90.60.4-0.5
Reaction time mean minus median0.10.10.60.10.00.00.0-0.00.80.4-0.1-0.3
Reaction time mean minus median AUC0.10.10.10.3-0.30.30.3-0.30.30.0-0.3-0.0
Reaction time num false alarms2.23.04.61.8-1.41.41.6-1.5-2.0-2.0-1.42.1
Reaction time num false alarms AUC2.13.04.51.9-1.41.41.6-1.5-1.9-2.0-1.52.1
Reaction time trials correct on left0.20.30.8-0.80.3-0.3-0.40.40.90.60.4-0.5
Reaction time trials on left0.20.30.8-0.80.3-0.3-0.40.40.90.50.4-0.5
Reaction time mean0.00.00.10.2-0.10.20.2-0.20.10.2-0.2-0.2
Reaction time mean AUC0.00.00.10.1-0.00.00.0-0.00.30.2-0.1-0.3
Median of all reaction times0.00.00.10.10.00.00.0-0.00.00.20.0-0.2
Reaction time omissions0.20.20.30.4-0.50.50.5-0.5-0.5-0.3-0.60.4
Reaction time false alarm rate2.73.75.12.2-1.61.61.8-1.7-2.2-2.1-1.72.3
Reaction time premature initiation rate0.20.30.60.8-0.40.50.4-0.4-0.4-0.4-0.50.7
Reaction time premature initiations0.00.00.10.3-0.20.20.1-0.20.1-0.1-0.20.3
Std. dev. reaction times0.10.20.30.5-0.50.50.5-0.50.30.0-0.6-0.0
Reaction time trials completed0.20.30.8-0.80.3-0.3-0.40.40.90.50.4-0.5
Reaction time trials AUC0.30.41.0-0.80.4-0.4-0.50.51.00.60.4-0.6
Run reversals in cocaine runway, females0.50.40.8-0.60.5-0.6-0.60.60.70.90.5-0.8
Run reversals in cocaine runway, males1.21.21.6-1.31.0-1.0-1.11.11.21.11.0-1.1
Latency to leave start box in cocaine runway0.70.71.4-0.80.7-0.6-0.70.71.21.20.6-0.9
Latency to leave start box in cocaine runway, F0.10.20.3-0.20.4-0.3-0.30.30.50.60.4-0.5
Latency to leave start box in cocaine runway, M2.22.12.8-1.61.2-1.2-1.41.31.71.71.2-1.5
Std. dev. time between licks in bursts0.91.11.61.3-0.91.01.0-1.0-1.2-1.1-1.01.0
Total sessions with >9 infusions6.67.38.3-2.92.7-2.7-2.82.82.22.62.8-2.7
Short access day 1 total inactive lever presses3.13.55.5-2.41.7-1.7-1.81.71.82.01.6-2.1
Short access day 10 total inactive lever presses0.10.10.10.3-0.20.20.2-0.20.3-0.2-0.40.3
Short access day 1 total infusions5.25.56.9-2.62.2-2.2-2.32.32.22.42.3-2.5
Short access day 10 total infusions6.77.49.1-3.02.7-2.7-2.72.72.52.92.7-2.6
Short access total infusions5.35.97.2-2.72.3-2.3-2.52.42.22.52.5-2.5
Short access day 1 locomotion6.26.79.3-2.52.3-2.3-2.52.53.02.82.6-2.7
Short access day 10 total locomotion1.31.51.7-0.91.3-1.3-1.21.31.31.31.3-1.0
Short access total locomotion2.42.52.9-1.51.5-1.5-1.61.61.61.71.6-1.5
One hour access (0.3 mA shock)2.22.65.0-2.21.6-1.5-1.61.61.11.51.6-1.5
Compulsive drug intake3.94.04.91.7-2.22.11.9-2.0-2.0-2.0-2.01.9
One hour access (shock baseline)6.37.39.2-3.02.8-2.8-2.72.72.22.62.7-2.6
Social response proportion0.10.20.4-0.60.3-0.4-0.40.30.50.40.2-0.4
Social responses0.10.10.30.2-0.40.30.4-0.40.0-0.5-0.30.4
Social time0.10.20.5-0.70.2-0.4-0.30.30.50.20.3-0.4
Soleus weight2.77.810.7-3.32.6-2.6-2.72.73.12.82.7-2.6
Bone: stiffness0.10.20.50.2-0.40.40.4-0.4-0.7-0.6-0.40.6
Tibialis anterior weight0.82.63.9-1.71.6-1.5-1.61.62.01.51.6-1.3
Time to tail flick, vehicle, before self-admin0.60.61.31.2-0.60.60.7-0.7-1.0-0.8-0.60.5
Time to tail flick, vehicle, after self-admin5.45.77.92.2-2.82.82.5-2.6-1.9-1.7-2.81.9
Time to tail flick, test, before self-admin1.11.11.7-0.71.1-1.1-1.01.10.91.11.2-1.3
Time to tail flick, test, after self-admin0.91.01.3-1.01.1-1.1-1.01.00.80.71.1-1.0
Delta time to tail flick, vehicle, before/after SA1.81.82.81.0-1.71.71.4-1.5-0.4-0.7-1.71.2
Delta time to tail flick, test, before/after SA1.61.51.9-1.41.3-1.3-1.21.21.20.91.2-1.1
Tibia length0.82.34.71.0-1.31.41.4-1.4-2.2-1.8-1.31.8
Ambulatory time before self-admin0.20.20.8-0.30.1-0.1-0.30.30.90.60.1-0.4
Ambulatory time after self-admin0.10.10.20.3-0.40.40.3-0.3-0.2-0.4-0.40.5
Bone: tissue strength0.40.40.70.5-0.80.80.7-0.8-0.4-0.3-0.80.4
Total heroin consumption1.21.52.1-1.01.3-1.3-1.31.30.61.11.3-1.4
Bone: trabecular number3.14.86.3-2.52.3-2.3-2.22.21.72.02.2-2.2
Bone: trabecular spacing0.91.21.71.3-1.01.01.0-1.0-1.2-1.2-1.01.2
Bone: trabecular thickness0.50.60.8-0.80.7-0.7-0.70.70.90.80.7-0.8
Bone: trabecular tissue density0.20.30.6-0.30.3-0.4-0.40.40.70.70.4-0.7
Water consumed over 24 hours0.00.00.0-0.00.2-0.1-0.10.10.20.00.10.0
Number of responses in last shaping day2.72.83.3-1.71.8-1.7-1.61.71.61.61.8-1.5