Hub : Genes

Hadha

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Hadha 0.12 0.1 1.2e-10 0.09 0.08 0.09 0.09 6.4e-10 1.4e-09 9.0e-10 1.1e-09
2 Brain mRNA stability Hadha 0.08 0.08 2.8e-07 0.05 0.06 0.06 0.05 8.5e-06 3.1e-06 6.1e-06 9.3e-06
3 PL gene expression Hadha 0.03 0.03 9.8e-04 0.02 0.03 0.01 0.02 1.6e-03 8.6e-04 2.4e-02 1.9e-03
4 Adipose gene expression Hadha 0.14 0.1 1.2e-13 0.1 0.11 0.1 0.1 1.5e-11 5.0e-12 2.3e-11 1.3e-11
5 Liver mRNA stability Hadha 0.05 0.04 1.0e-04 0.03 0.04 0.03 0.03 1.2e-04 7.4e-05 1.7e-04 1.3e-04
6 Brain gene expression Hadha 0.06 0.05 2.2e-05 0.05 0.05 0.05 0.05 1.3e-05 1.7e-05 1.4e-05 1.5e-05
7 RMTg mRNA stability Hadha 0.19 0.17 3.0e-03 0.05 0.03 0.03 0.04 2.0e-02 4.9e-02 4.5e-02 4.1e-02
8 NAcc gene expression Hadha 0.01 0.02 7.5e-03 0.01 0.01 0.01 0.01 5.6e-03 9.8e-03 6.6e-03 9.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.13.73.8-1.91.9-1.9-1.91.9-1.91.9-1.9
Area under the delay curve0.00.00.1-0.40.1-0.1-0.10.10.10.2-0.2
BMI with tail2.06.97.72.7-2.62.62.6-2.62.5-2.82.6
BMI without tail2.16.36.72.6-2.52.52.5-2.52.5-2.62.5
Body weight2.29.813.83.7-3.13.13.1-3.13.1-2.92.9
Weight adjusted by age0.00.00.1-0.0-0.30.20.2-0.20.3-0.00.2
Bone surface0.30.50.5-0.70.7-0.7-0.70.7-0.70.7-0.7
Bone volume0.91.71.8-1.11.3-1.3-1.31.3-1.41.3-1.3
Breakpoint value in progressive ratio session0.60.71.1-0.40.9-0.9-0.90.9-0.81.0-1.0
Number of licking bursts1.01.61.71.1-1.31.31.3-1.31.3-1.31.3
Context. condit. distance diff. score0.30.40.6-0.50.6-0.6-0.60.6-0.60.7-0.6
Locomotion velocity, session 10.60.60.80.4-0.80.80.8-0.80.8-0.80.9
Locomotion distance, session 10.40.50.9-1.00.6-0.6-0.60.6-0.60.6-0.6
Locomotion velocity, session 20.00.00.20.4-0.20.20.2-0.20.1-0.20.2
Locomotion distance, session 20.10.10.10.1-0.30.30.3-0.30.3-0.30.3
Locomotion velocity, session 30.00.10.2-0.50.2-0.2-0.20.2-0.10.2-0.2
Locomotion distance, session 30.00.10.1-0.2-0.20.20.2-0.20.2-0.20.2
Stereotopy head waving bouts, day 32.02.42.7-1.21.6-1.6-1.61.6-1.61.6-1.6
Stereotopy head waving duration, day 30.60.70.8-0.30.8-0.8-0.80.8-0.90.9-0.9
Locomotion velocity, session 70.00.00.00.2-0.10.10.1-0.10.1-0.00.1
Locomotion distance, session 70.81.11.31.0-1.01.01.0-1.01.1-1.01.0
Stereotopy head waving bouts, day 70.00.00.20.4-0.10.10.1-0.10.0-0.10.1
Stereotopy head waving duration, day 70.40.40.5-0.60.7-0.7-0.70.7-0.70.6-0.7
Locomotion velocity, session 80.40.50.6-0.60.8-0.7-0.70.7-0.70.7-0.8
Locomotion distance, session 80.30.40.5-0.60.6-0.6-0.60.6-0.60.7-0.6
Degree of sensitization distance0.90.91.71.3-0.90.90.9-0.91.0-0.90.9
Degree of sensitization stereotypy0.30.40.70.8-0.60.60.6-0.60.5-0.60.6
Conditioned locomotion3.23.75.0-2.22.0-1.9-1.91.9-1.71.8-1.8
Cocaine response after cond. corrected0.10.10.2-0.40.4-0.4-0.40.4-0.40.4-0.4
Cocaine response after cond. not corrected0.70.81.0-1.00.9-0.9-0.90.9-0.90.9-0.9
Cocaine response before conditioning2.63.13.7-1.91.8-1.7-1.71.7-1.81.7-1.7
Saline control response1.11.41.5-0.91.2-1.2-1.21.2-1.21.2-1.2
Bone: connectivity density1.32.02.0-1.41.4-1.4-1.41.4-1.41.4-1.4
Bone: cortical apparent density0.00.00.1-0.30.2-0.2-0.20.2-0.10.2-0.2
Bone: cortical area0.00.00.10.2-0.20.20.2-0.20.2-0.10.2
Bone: cortical porosity3.33.63.8-2.01.9-1.9-1.91.9-1.81.9-1.9
Bone: cortical porosity2.83.13.1-1.81.7-1.8-1.81.8-1.71.7-1.8
Bone: cortical thickness0.20.40.40.6-0.60.60.6-0.60.7-0.60.6
Bone: cortical thickness0.30.30.5-0.70.5-0.5-0.50.5-0.50.6-0.5
Bone: cortical tissue density0.00.00.0-0.20.1-0.1-0.10.1-0.10.1-0.1
Condit. Reinf. active minus inactive responses1.92.22.31.3-1.51.51.5-1.51.5-1.51.5
Condit. Reinf. active-inactive response ratio1.61.81.91.2-1.31.41.4-1.41.3-1.31.3
Condit. Reinf. active responses0.10.10.2-0.0-0.40.40.4-0.40.4-0.40.4
Condit. Reinf. inactive responses0.91.11.4-1.21.1-1.1-1.11.1-1.01.0-1.0
Incentive salience index mean0.20.20.30.4-0.50.50.5-0.50.5-0.50.5
Condit. Reinf. lever presses0.81.11.2-0.91.1-1.1-1.11.1-1.01.1-1.0
Condit. Reinf. active minus inactive responses1.21.64.8-2.21.1-1.1-1.11.1-1.01.0-1.0
Condit. Reinf. active-inactive response ratio0.60.71.9-1.40.7-0.7-0.70.7-0.60.7-0.7
Condit. Reinf. active responses0.71.03.3-1.80.8-0.8-0.80.8-0.80.8-0.8
Condit. Reinf. inactive responses0.10.20.4-0.60.4-0.4-0.40.4-0.40.4-0.4
Condit. Reinf. lever presses1.21.63.4-1.81.2-1.2-1.21.2-1.21.1-1.1
Condit. Reinf. lever reinforcers received0.70.93.0-1.70.8-0.8-0.80.8-0.70.8-0.8
Conditioned reinforcement - actives3.96.68.6-2.92.7-2.5-2.52.5-2.62.4-2.3
Conditioned reinforcement - inactives4.46.57.4-2.12.6-2.6-2.62.6-2.62.7-2.6
Conditioned locomotion1.92.42.8-1.61.6-1.5-1.51.5-1.71.5-1.4
Patch foraging indifference point 0 sec0.51.01.41.2-1.11.01.0-1.00.8-1.00.9
Patch foraging indifference point AUC0.00.00.0-0.1-0.10.10.1-0.00.2-0.10.1
Delay disc. indifference point, 0s delay0.91.01.30.9-1.00.90.9-0.91.1-1.11.1
Delay disc. indifference point, 16s delay0.00.00.2-0.5-0.10.10.1-0.10.30.2-0.1
Delay disc. indifference point, 2s delay0.10.10.20.2-0.30.30.3-0.30.5-0.20.3
Delay disc. indifference point, 24s delay2.12.42.5-1.61.5-1.6-1.51.5-1.51.6-1.6
Delay disc. indifference point, 4s delay0.10.10.20.2-0.30.30.3-0.30.4-0.30.3
Delay disc. indifference point, 8s delay0.00.00.1-0.30.2-0.2-0.10.1-0.10.2-0.2
Indifference point function ln k1.22.02.3-1.11.5-1.5-1.51.4-1.51.5-1.5
Indifference point function log k1.22.02.3-1.11.5-1.5-1.51.4-1.51.5-1.5
Patch foraging total patch changes 0 sec0.61.11.81.3-1.11.01.0-1.00.8-1.00.9
Patch foraging total patch changes 12 sec1.21.62.61.6-1.31.21.2-1.21.2-1.11.1
Patch foraging total patch changes 18 sec1.11.62.11.5-1.31.21.2-1.21.3-1.21.2
Patch foraging total patch changes 24 sec1.11.92.11.3-1.41.41.4-1.41.4-1.31.3
Patch foraging total patch changes 6 sec1.92.93.31.5-1.81.71.7-1.71.7-1.71.7
Patch foraging time to switch 0 sec0.20.40.70.9-0.70.70.7-0.70.6-0.60.6
Patch foraging water rate 0 sec0.71.51.6-0.91.2-1.2-1.21.2-1.31.3-1.3
Patch foraging water rate 12 sec0.00.10.10.2-0.20.30.3-0.30.3-0.20.2
Patch foraging water rate 18 sec0.71.11.4-0.71.1-1.1-1.11.1-1.11.1-1.2
Patch foraging water rate 24 sec0.20.31.01.0-0.40.40.4-0.40.5-0.40.4
Patch foraging water rate 6 sec0.10.20.2-0.20.4-0.4-0.40.4-0.40.5-0.5
Seeking ratio, delayed vs. immediate footshock0.00.10.10.0-0.30.30.3-0.20.3-0.20.2
Distance traveled before self-admin0.10.20.6-0.80.4-0.3-0.30.3-0.30.1-0.2
Distance traveled after self-admin1.01.21.41.2-1.01.11.1-1.11.1-1.11.1
Extensor digitorum longus weight2.28.710.9-3.33.0-2.9-2.92.9-2.72.9-2.9
Bone: elastic displacement1.61.82.7-1.71.3-1.3-1.31.3-1.41.2-1.3
Bone: elastic work0.50.71.4-1.20.8-0.8-0.80.8-0.80.8-0.8
Bone: endosteal estimation0.10.20.3-0.10.4-0.4-0.40.4-0.50.4-0.4
Bone: endosteal perimeter0.00.00.00.00.0-0.1-0.10.1-0.10.1-0.1
Epididymis fat weight16.355.757.17.6-7.57.57.5-7.57.4-7.47.4
Delta time in closed arm before/after self-admin0.20.20.90.9-0.40.30.2-0.20.2-0.00.1
Delta time in open arm before/after self-admin0.00.00.0-0.0-0.00.00.1-0.10.1-0.10.0
Diff in mean of infusions in LGA sessions0.10.10.20.4-0.30.20.3-0.30.2-0.00.2
Delay discount exponential model param0.10.10.40.6-0.30.30.3-0.30.1-0.50.4
Extinction: sum of active levers before priming0.60.71.00.20.8-0.8-0.80.8-0.91.0-1.0
Active lever presses in extinction session 61.91.92.5-0.81.4-1.4-1.41.4-1.21.5-1.6
Bone: final force0.00.00.00.2-0.20.10.1-0.10.1-0.10.1
Bone: final moment0.00.00.00.1-0.10.10.1-0.10.1-0.10.1
Food consumed during 24 hour testing period0.10.10.1-0.0-0.30.30.3-0.30.3-0.30.3
Glucose0.81.31.40.9-1.21.21.2-1.21.2-1.21.2
Heart weight1.21.93.41.8-1.31.31.3-1.31.3-1.31.3
Delay discount hyperbolic model param0.00.00.10.3-0.10.10.1-0.1-0.1-0.20.2
Intermittent access intake day 1-15 change0.40.81.0-0.71.0-0.9-0.90.9-1.00.9-0.9
Intermittent access intake escalation0.20.30.4-0.40.6-0.6-0.60.6-0.60.5-0.6
Intermittent access intake escalation 20.00.00.00.10.2-0.1-0.10.1-0.10.0-0.1
Intermitt. access day 1 inactive lever presses0.41.41.5-1.21.2-1.2-1.21.2-1.01.2-1.2
Intermitt. access day 15 inactive lever presses0.91.92.2-1.51.3-1.3-1.31.3-1.21.4-1.5
Intermitt. access escalation Index4.36.07.12.7-2.52.42.4-2.42.4-2.42.4
Intermittent access day 1 total infusions2.74.36.8-2.62.1-2.0-2.02.0-2.02.1-1.9
Intermittent access day 15 total infusions2.43.54.1-2.01.9-1.8-1.81.8-1.91.9-1.8
Intermittent access terminal intake (last 3 days)3.64.86.0-2.52.2-2.1-2.12.1-2.22.2-2.1
Intermittent access total infusions4.85.66.8-2.62.4-2.3-2.32.3-2.32.4-2.3
Intermittent access day 1 locomotion2.53.13.3-1.81.8-1.8-1.81.8-1.81.7-1.7
Intermittent access day 15 total locomotion0.10.10.4-0.60.4-0.3-0.30.3-0.40.2-0.2
Intermittent access total locomotion1.21.51.7-1.01.3-1.3-1.31.2-1.31.2-1.2
Intermittent access standard deviation1.02.12.4-1.51.5-1.4-1.41.4-1.51.4-1.3
Left kidney weight0.20.71.00.00.8-0.9-0.90.9-1.01.0-1.0
Right kidney weight0.10.21.21.1-0.30.30.3-0.30.2-0.30.3
Cocaine induced anxiety0.00.10.10.30.2-0.2-0.20.2-0.30.3-0.3
Post-drug Anxiety1.61.72.21.5-1.31.31.3-1.31.3-1.21.2
Baseline Anxiety3.23.84.21.4-2.02.02.0-2.02.0-2.02.0
Tail length0.00.00.20.40.0-0.1-0.10.1-0.10.3-0.2
Length with tail0.10.52.01.4-0.60.50.5-0.50.5-0.20.4
Length without tail0.00.10.91.0-0.10.0-0.00.0-0.00.2-0.2
Times rat made contact with spout0.50.60.6-0.70.8-0.8-0.80.8-0.70.7-0.7
Lifetime Intake5.16.26.8-2.52.5-2.5-2.52.4-2.52.6-2.4
Liver weight, left1.93.24.12.0-1.71.71.7-1.71.8-1.71.7
Liver weight, right3.56.211.03.3-2.32.32.3-2.42.3-2.32.3
Locomotor activity0.60.91.51.2-0.90.90.9-0.90.8-1.00.9
Locomotor testing distance0.30.50.60.7-0.70.70.7-0.70.6-0.70.7
Locomotor testing rearing0.20.50.6-0.50.7-0.7-0.70.7-0.70.7-0.7
Locomotion in novel chamber0.10.10.10.3-0.20.20.2-0.20.3-0.30.3
Locomotion in novel chamber post-restriction2.54.05.32.3-2.02.02.0-2.02.0-1.82.0
Fecal boli incidents, locomotor time 11.82.63.0-1.01.6-1.7-1.71.7-1.71.7-1.7
Change in fecal boli incidents, locomotor task3.53.54.02.0-1.91.91.9-1.92.0-1.61.7
Time >=10cm from walls, locomotor time 10.40.40.5-0.50.6-0.6-0.70.7-0.70.6-0.7
Bouts of movement, locomotor time 10.00.00.1-0.3-0.10.10.1-0.10.2-0.20.1
Total resting periods, locomotor time 10.00.00.1-0.4-0.10.00.1-0.00.2-0.2-0.0
Rest time, locomotor task time 10.20.30.6-0.1-0.50.50.5-0.50.6-0.80.6
Distance moved, locomotor task time 10.10.21.01.0-0.30.30.3-0.30.2-0.10.1
Vertical activity count, locomotor time 10.00.10.30.5-0.20.20.2-0.20.2-0.00.1
Time >=10cm from walls, locomotor time 21.31.92.2-1.51.4-1.4-1.41.4-1.31.3-1.3
Bouts of movement, locomotor time 20.30.40.60.5-0.80.70.7-0.70.7-0.60.5
Total resting periods, locomotor time 20.30.50.60.4-0.80.80.8-0.70.8-0.70.5
Rest time, locomotor task time 20.00.10.4-0.6-0.00.00.0-0.0-0.0-0.30.1
Distance moved, locomotor task time 20.00.00.10.40.1-0.0-0.10.10.1-0.0-0.0
Vertical activity count, locomotor time 20.10.10.20.00.4-0.4-0.40.4-0.30.4-0.4
Light reinforcement 10.41.01.2-0.90.9-1.0-1.01.0-1.01.1-1.1
Light reinforcement 20.91.41.8-1.31.1-1.1-1.21.2-1.21.2-1.2
Bone: marrow area0.10.20.3-0.10.4-0.4-0.40.4-0.50.4-0.4
Bone: maximum diameter0.00.00.10.3-0.0-0.0-0.00.0-0.10.0-0.0
Bone: maximum force0.00.00.0-0.20.1-0.1-0.10.1-0.10.1-0.1
Bone: maximum moment0.00.00.1-0.30.1-0.1-0.10.2-0.20.2-0.2
Mean time between licks in bursts0.82.13.01.7-1.41.41.4-1.41.3-1.41.4
Mean num. licks in bursts1.21.81.9-1.11.4-1.4-1.41.4-1.41.4-1.4
Cd content in liver0.00.00.20.4-0.20.20.2-0.20.0-0.10.1
Co content in liver5.66.47.0-2.52.5-2.5-2.52.5-2.72.6-2.6
Cu content in liver0.40.50.9-1.00.7-0.7-0.70.7-0.70.7-0.7
Fe content in liver1.92.32.4-1.61.6-1.5-1.51.5-1.51.5-1.5
K content in liver0.10.10.10.4-0.40.30.3-0.30.2-0.30.3
Mg content in liver0.00.00.20.5-0.1-0.0-0.00.1-0.20.1-0.1
Mn content in liver0.80.81.41.2-1.00.90.9-0.90.8-0.80.8
Na content in liver2.32.52.7-1.61.6-1.6-1.61.6-1.61.6-1.6
Rb content in liver0.10.10.60.8-0.40.30.3-0.30.2-0.20.2
Se content in liver0.10.10.20.4-0.40.40.4-0.40.3-0.40.4
Sr content in liver0.10.10.3-0.50.3-0.3-0.30.3-0.30.3-0.3
Zn content in liver0.40.40.60.5-0.80.70.7-0.70.5-0.60.6
Bone: minimum diameter0.50.91.41.2-1.00.90.9-0.90.8-0.80.9
Time in familiar zone, hab. session 10.80.81.61.3-0.90.80.8-0.80.8-0.80.8
Time in novel zone, hab. session 10.30.30.30.4-0.50.50.5-0.50.5-0.50.5
Total zone transitions, hab. session 10.10.20.2-0.30.4-0.4-0.40.4-0.40.4-0.4
Total locomotion distance, hab. session 10.60.81.0-0.41.0-1.0-1.01.0-1.01.0-1.0
Locomotion velocity, hab. session 11.21.81.9-1.11.4-1.4-1.41.3-1.41.4-1.4
Time in familiar zone, hab. session 20.30.30.40.5-0.60.60.6-0.60.6-0.50.5
Time in novel zone, hab. session 20.00.00.10.2-0.10.10.1-0.10.1-0.20.1
Total zone transitions, hab. session 20.20.20.20.4-0.50.50.5-0.50.4-0.50.5
Total locomotion distance, hab. session 20.20.30.30.1-0.60.60.6-0.60.5-0.60.5
Locomotion velocity, hab. session 20.10.10.2-0.1-0.40.40.4-0.40.4-0.40.4
Novel to familiar place preference ratio0.50.61.31.2-0.70.70.7-0.70.7-0.70.7
Novelty place preference0.91.01.91.4-0.90.90.9-0.90.9-1.00.9
Time in novel zone, NPP test0.91.02.01.4-0.90.90.9-0.90.9-0.90.9
Total zone transitions, NPP test0.91.31.7-1.31.1-1.1-1.11.1-1.21.1-1.1
Total locomotion distance, NPP test1.21.71.9-1.41.3-1.3-1.31.3-1.31.3-1.3
Locomotion velocity, NPP test1.62.32.7-1.71.5-1.5-1.51.5-1.51.5-1.5
Intraocular pressure5.07.211.63.4-2.52.52.5-2.52.6-2.72.5
Delta distance traveled before/after self-admin2.52.63.11.8-1.71.61.6-1.61.7-1.51.5
Delta ambulatory time before/after self-admin0.60.71.41.2-0.90.80.8-0.80.9-0.70.7
Parametrial fat weight18.242.744.75.8-6.76.76.7-6.76.6-6.56.7
Pavlov. Cond. lever latency0.50.60.91.0-0.80.80.8-0.80.8-0.80.7
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.10.10.1-0.10.1-0.10.1
Pavlov. Cond. change in total contacts0.10.10.1-0.20.3-0.3-0.20.2-0.30.3-0.2
Pavlov. Cond. index score0.00.10.1-0.20.3-0.3-0.30.3-0.20.3-0.2
Pavlov. Cond. latency score0.00.00.0-0.10.1-0.1-0.10.1-0.10.1-0.1
Pavlov. Cond. lever contacts0.50.60.7-0.80.8-0.8-0.80.8-0.70.7-0.7
Pavlov. Cond. magazine entry number0.00.00.00.2-0.10.10.1-0.10.1-0.10.1
Pavlov. Cond. intertrial magazine entries2.22.63.0-1.71.6-1.6-1.61.6-1.61.6-1.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.4-0.60.6-0.6-0.60.6-0.60.6-0.6
Pavlov. Cond. response bias0.70.90.9-0.90.9-0.9-0.90.9-0.91.0-0.9
Pavlov. Cond. lever latency0.70.92.21.5-0.90.90.9-0.90.8-0.80.8
Pavlov. Cond. magazine entry latency0.10.10.2-0.5-0.20.20.2-0.20.3-0.20.2
Pavlov. Cond. change in total contacts0.10.10.7-0.80.2-0.2-0.10.2-0.00.1-0.1
Pavlov. Cond. index score0.30.51.7-1.30.6-0.6-0.50.6-0.50.5-0.5
Pavlov. Cond. latency score0.40.51.8-1.40.6-0.6-0.60.6-0.50.5-0.5
Pavlov. Cond. lever contacts0.40.61.5-1.20.7-0.7-0.70.7-0.60.6-0.6
Pavlov. Cond. magazine entry number0.10.10.20.30.4-0.4-0.40.4-0.40.4-0.4
Pavlov. Cond. intertrial magazine entries2.33.44.72.2-1.91.81.8-1.81.8-1.71.7
Pavlov. Cond. lever-magazine prob. diff.0.10.21.0-1.00.2-0.2-0.20.2-0.10.2-0.2
Pavlov. Cond. response bias0.60.82.3-1.50.8-0.8-0.80.8-0.70.7-0.7
Time in closed arm before self-admin0.40.50.80.8-0.60.60.6-0.70.6-0.90.8
Time in closed arm after self-admin1.11.21.71.3-1.01.01.0-1.01.0-1.11.2
Time in open arm before self-admin0.00.00.10.00.0-0.1-0.10.1-0.10.3-0.3
Time in open arm after self-admin0.20.20.3-0.40.5-0.5-0.50.5-0.50.4-0.5
Bone: periosteal estimation0.10.20.3-0.10.4-0.5-0.50.5-0.50.5-0.5
Bone: periosteal perimeter0.00.00.0-0.00.0-0.1-0.10.1-0.10.1-0.1
Bone: post-yield work1.92.83.2-1.51.6-1.7-1.71.7-1.81.7-1.7
Progressive ratio test 1 active lever presses3.03.84.0-2.02.0-1.9-1.91.9-1.92.0-1.9
Progressive ratio test 1 breakpoint3.23.94.1-2.02.0-2.0-2.01.9-1.92.0-1.9
Progressive ratio test 1 inactive lever presses4.66.67.0-2.42.6-2.6-2.62.6-2.52.6-2.6
Progressive ratio test 2 active lever presses3.23.74.2-1.82.0-1.9-1.91.9-1.92.0-2.0
Progressive ratio test 2 breakpoint3.03.53.9-1.71.9-1.9-1.91.9-1.92.0-1.9
Progressive ratio test 2 inactive lever presses2.74.44.7-1.92.2-2.1-2.12.1-2.02.2-2.1
Incentive Sensitization - Responses1.92.63.2-1.11.6-1.7-1.71.7-1.71.8-1.8
Incentive Sensitization - Breakpoint1.62.02.5-0.91.4-1.4-1.51.5-1.51.6-1.5
Sum of active levers in priming session hrs 5-60.20.20.70.9-0.50.40.4-0.40.40.10.2
Progressive ratio0.00.00.00.2-0.20.20.2-0.20.2-0.10.2
Food seeking constrained by brief footshock13.216.118.0-2.84.0-4.1-4.14.2-4.24.2-4.2
Seeking ratio, punishment vs. effort1.52.12.5-1.11.5-1.5-1.51.5-1.51.4-1.6
Retroperitoneal fat weight33.3142.0145.511.4-12.112.012.0-12.012.0-11.811.9
Reaction time number correct0.10.20.4-0.70.5-0.4-0.40.4-0.40.4-0.4
Reaction time mean minus median0.00.10.3-0.6-0.00.10.1-0.10.1-0.20.1
Reaction time mean minus median AUC0.00.10.2-0.1-0.40.40.4-0.40.3-0.40.3
Reaction time num false alarms1.72.52.91.7-1.71.61.6-1.61.5-1.51.5
Reaction time num false alarms AUC1.72.63.01.7-1.71.61.6-1.61.5-1.61.6
Reaction time trials correct on left0.10.20.4-0.70.5-0.4-0.40.4-0.40.4-0.4
Reaction time trials on left0.10.20.4-0.60.4-0.4-0.40.4-0.40.4-0.4
Reaction time mean0.00.10.20.4-0.20.20.2-0.20.3-0.30.2
Reaction time mean AUC0.00.00.10.4-0.10.10.1-0.10.2-0.20.1
Median of all reaction times0.00.10.30.6-0.10.10.1-0.10.1-0.20.1
Reaction time omissions0.20.20.50.7-0.40.50.5-0.50.5-0.40.4
Reaction time false alarm rate2.33.13.51.8-1.91.81.8-1.81.6-1.71.7
Reaction time premature initiation rate0.10.10.20.0-0.40.40.4-0.40.3-0.40.4
Reaction time premature initiations0.00.00.1-0.2-0.10.10.1-0.10.1-0.10.1
Std. dev. reaction times0.10.30.50.1-0.40.50.5-0.60.5-0.70.6
Reaction time trials completed0.10.20.4-0.60.4-0.4-0.40.4-0.40.4-0.4
Reaction time trials AUC0.10.30.6-0.80.5-0.5-0.50.5-0.50.5-0.4
Run reversals in cocaine runway, females0.60.60.8-0.90.8-0.8-0.80.7-0.70.7-0.6
Run reversals in cocaine runway, males0.80.91.0-0.91.0-1.0-1.01.0-0.90.8-0.9
Latency to leave start box in cocaine runway0.80.92.2-1.50.9-0.8-0.80.8-0.81.0-0.8
Latency to leave start box in cocaine runway, F0.10.20.5-0.70.3-0.3-0.30.3-0.30.4-0.3
Latency to leave start box in cocaine runway, M0.90.91.8-1.30.9-0.9-0.90.9-0.80.8-0.8
Std. dev. time between licks in bursts1.01.32.31.5-1.11.11.1-1.11.1-1.11.1
Total sessions with >9 infusions2.63.13.8-1.71.8-1.7-1.81.7-1.91.8-1.6
Short access day 1 total inactive lever presses4.86.37.5-2.02.7-2.6-2.62.6-2.72.5-2.4
Short access day 10 total inactive lever presses0.51.11.6-1.31.1-1.1-1.11.1-1.00.8-1.0
Short access day 1 total infusions4.15.46.3-2.22.4-2.3-2.32.3-2.52.5-2.1
Short access day 10 total infusions4.55.76.1-2.42.5-2.4-2.42.4-2.42.4-2.3
Short access total infusions2.83.64.5-1.62.0-1.9-1.91.9-2.02.1-1.8
Short access day 1 locomotion2.73.34.6-2.21.9-1.8-1.81.8-1.91.6-1.6
Short access day 10 total locomotion1.22.22.8-1.51.5-1.5-1.51.5-1.71.3-1.4
Short access total locomotion1.11.41.8-0.91.2-1.2-1.21.2-1.31.1-1.1
One hour access (0.3 mA shock)2.93.34.3-2.12.0-1.8-1.81.8-1.71.8-1.7
Compulsive drug intake2.73.24.02.0-1.71.71.7-1.81.7-1.91.8
One hour access (shock baseline)4.77.18.0-2.82.7-2.7-2.72.6-2.52.8-2.7
Social response proportion0.10.10.1-0.30.3-0.2-0.20.2-0.30.2-0.2
Social responses0.10.20.3-0.0-0.50.50.5-0.50.3-0.40.4
Social time0.00.10.1-0.00.2-0.2-0.20.2-0.40.3-0.2
Soleus weight2.98.710.1-3.23.0-2.9-2.92.9-2.92.9-2.9
Bone: stiffness0.00.10.10.2-0.30.20.2-0.20.3-0.20.2
Tibialis anterior weight1.03.46.4-2.51.8-1.8-1.71.7-1.71.7-1.7
Time to tail flick, vehicle, before self-admin0.00.00.10.3-0.10.00.0-0.00.20.1-0.1
Time to tail flick, vehicle, after self-admin3.95.26.31.6-2.22.42.4-2.42.3-2.32.5
Time to tail flick, test, before self-admin0.10.10.20.10.4-0.4-0.40.4-0.40.3-0.3
Time to tail flick, test, after self-admin1.31.42.1-0.71.2-1.2-1.21.2-1.11.5-1.2
Delta time to tail flick, vehicle, before/after SA1.81.72.40.6-1.31.41.4-1.41.3-1.41.5
Delta time to tail flick, test, before/after SA2.72.83.4-1.61.6-1.6-1.61.6-1.71.8-1.6
Tibia length0.92.66.92.6-1.51.51.4-1.51.3-1.31.3
Ambulatory time before self-admin0.10.20.6-0.80.5-0.4-0.40.4-0.40.2-0.3
Ambulatory time after self-admin0.30.40.70.8-0.60.60.6-0.60.6-0.60.6
Bone: tissue strength0.60.60.70.5-0.80.80.8-0.80.8-0.80.8
Total heroin consumption2.12.42.8-1.21.6-1.6-1.61.6-1.51.7-1.7
Bone: trabecular number2.23.63.8-1.71.9-1.9-1.91.9-1.91.9-1.9
Bone: trabecular spacing0.70.91.71.3-0.90.90.9-0.90.9-0.90.9
Bone: trabecular thickness0.30.40.4-0.50.6-0.6-0.60.6-0.60.6-0.6
Bone: trabecular tissue density0.30.40.5-0.70.7-0.6-0.60.6-0.70.6-0.5
Water consumed over 24 hours0.20.30.40.1-0.60.60.6-0.60.7-0.60.6
Number of responses in last shaping day1.51.72.2-0.51.3-1.3-1.41.3-1.31.5-1.4