Hub : Genes

Hadha

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Hadha 0.12 0.1 1.2e-10 0.09 0.08 0.09 0.09 6.4e-10 1.4e-09 9.0e-10 1.1e-09
2 Brain mRNA stability Hadha 0.08 0.08 2.8e-07 0.05 0.06 0.06 0.05 8.5e-06 3.1e-06 5.2e-06 9.2e-06
3 PL gene expression Hadha 0.03 0.03 9.8e-04 0.02 0.03 0.01 0.02 1.6e-03 8.6e-04 2.5e-02 1.9e-03
4 Adipose gene expression Hadha 0.14 0.1 1.2e-13 0.1 0.11 0.1 0.1 1.5e-11 5.0e-12 2.6e-11 1.2e-11
5 Liver mRNA stability Hadha 0.05 0.04 1.0e-04 0.03 0.04 0.03 0.03 1.2e-04 7.4e-05 1.9e-04 1.3e-04
6 Brain gene expression Hadha 0.06 0.05 2.2e-05 0.05 0.05 0.05 0.05 1.3e-05 1.7e-05 1.4e-05 1.6e-05
7 RMTg mRNA stability Hadha 0.19 0.17 3.0e-03 0.05 0.03 0.03 0.04 2.0e-02 4.9e-02 4.5e-02 4.1e-02
8 NAcc gene expression Hadha 0.01 0.02 7.5e-03 0.01 0.01 0.01 0.01 5.6e-03 9.8e-03 6.6e-03 9.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.03.73.81.91.9-1.9-1.91.91.9-1.91.9
Area under the delay curve0.00.00.10.40.1-0.1-0.10.1-0.1-0.20.2
BMI with tail2.06.97.7-2.7-2.62.62.6-2.6-2.52.8-2.6
BMI without tail1.26.36.7-2.6-2.52.52.5-2.5-2.52.6-2.5
Body weight2.29.813.8-3.7-3.13.13.1-3.1-3.12.9-2.9
Weight adjusted by age0.00.00.10.0-0.30.20.2-0.2-0.30.0-0.2
Bone surface0.20.50.50.70.7-0.7-0.70.70.7-0.70.7
Bone volume0.91.71.81.11.3-1.3-1.31.31.4-1.31.3
Breakpoint value in progressive ratio session0.40.71.10.40.9-0.9-0.90.90.8-1.01.0
Number of licking bursts0.51.61.7-1.1-1.31.31.3-1.3-1.31.3-1.3
Context. condit. distance diff. score0.30.40.60.50.6-0.6-0.60.60.6-0.70.6
Locomotion velocity, session 10.50.60.8-0.4-0.80.80.8-0.8-0.80.8-0.9
Locomotion distance, session 10.40.50.91.00.6-0.6-0.60.60.6-0.60.6
Locomotion velocity, session 20.00.00.2-0.4-0.20.20.2-0.2-0.10.2-0.2
Locomotion distance, session 20.10.10.1-0.1-0.30.30.3-0.3-0.30.3-0.3
Locomotion velocity, session 30.00.10.20.50.2-0.2-0.20.20.1-0.20.2
Locomotion distance, session 30.00.10.10.2-0.20.20.2-0.2-0.20.2-0.2
Stereotopy head waving bouts, day 32.02.42.71.21.6-1.6-1.61.61.6-1.61.6
Stereotopy head waving duration, day 30.50.70.80.30.8-0.8-0.80.80.9-0.90.9
Locomotion velocity, session 70.00.00.0-0.2-0.10.10.1-0.1-0.10.0-0.1
Locomotion distance, session 70.81.11.3-1.0-1.01.01.0-1.0-1.11.0-1.0
Stereotopy head waving bouts, day 70.00.00.2-0.4-0.10.10.1-0.1-0.00.1-0.1
Stereotopy head waving duration, day 70.40.40.50.60.7-0.7-0.70.70.7-0.60.7
Locomotion velocity, session 80.40.50.60.60.8-0.7-0.70.70.7-0.70.8
Locomotion distance, session 80.30.40.50.60.6-0.6-0.60.60.6-0.70.6
Degree of sensitization distance0.90.91.7-1.3-0.90.90.9-0.9-1.00.9-0.9
Degree of sensitization stereotypy0.30.40.7-0.8-0.60.60.6-0.6-0.50.6-0.6
Conditioned locomotion3.13.75.02.22.0-1.9-1.91.91.7-1.81.8
Cocaine response after cond. corrected0.10.10.20.40.4-0.4-0.40.40.4-0.40.4
Cocaine response after cond. not corrected0.60.81.01.00.9-0.9-0.90.90.9-0.90.9
Cocaine response before conditioning2.63.13.71.91.8-1.7-1.71.71.8-1.71.7
Saline control response1.01.41.50.91.2-1.2-1.21.21.2-1.21.2
Bone: connectivity density1.22.02.01.41.4-1.4-1.41.41.4-1.41.4
Bone: cortical apparent density0.00.00.10.30.2-0.2-0.20.20.1-0.20.2
Bone: cortical area0.00.00.1-0.2-0.20.20.2-0.2-0.20.1-0.2
Bone: cortical porosity3.33.63.82.01.9-1.9-1.91.91.8-1.91.9
Bone: cortical porosity2.83.13.11.81.7-1.8-1.81.81.7-1.71.8
Bone: cortical thickness0.20.40.4-0.6-0.60.60.6-0.6-0.70.6-0.6
Bone: cortical thickness0.30.30.50.70.5-0.5-0.50.50.5-0.60.5
Bone: cortical tissue density0.00.00.00.20.1-0.1-0.10.10.1-0.10.1
Condit. Reinf. active minus inactive responses1.92.22.3-1.3-1.51.51.5-1.5-1.51.5-1.5
Condit. Reinf. active-inactive response ratio1.61.81.9-1.2-1.31.41.4-1.4-1.31.3-1.3
Condit. Reinf. active responses0.10.10.20.0-0.40.40.4-0.4-0.40.4-0.4
Condit. Reinf. inactive responses0.91.11.41.21.1-1.1-1.11.11.0-1.01.0
Incentive salience index mean0.20.20.3-0.4-0.50.50.5-0.5-0.50.5-0.5
Condit. Reinf. lever presses0.71.11.20.91.1-1.1-1.11.11.0-1.11.0
Condit. Reinf. active minus inactive responses1.01.64.82.21.1-1.1-1.11.11.0-1.01.0
Condit. Reinf. active-inactive response ratio0.40.71.91.40.7-0.7-0.70.70.6-0.70.7
Condit. Reinf. active responses0.71.03.31.80.8-0.8-0.80.80.8-0.80.8
Condit. Reinf. inactive responses0.10.20.40.60.4-0.4-0.40.40.4-0.40.4
Condit. Reinf. lever presses1.11.63.41.81.2-1.2-1.21.21.2-1.11.1
Condit. Reinf. lever reinforcers received0.60.93.01.70.8-0.8-0.80.80.7-0.80.8
Conditioned reinforcement - actives1.76.68.62.92.7-2.5-2.52.52.6-2.42.3
Conditioned reinforcement - inactives2.46.57.42.12.6-2.6-2.62.62.6-2.72.6
Conditioned locomotion1.62.42.81.61.6-1.5-1.51.51.7-1.51.4
Patch foraging indifference point 0 sec0.41.01.4-1.2-1.11.01.0-1.0-0.81.0-0.9
Patch foraging indifference point AUC0.00.00.00.1-0.10.10.1-0.0-0.20.1-0.1
Delay disc. indifference point, 0s delay0.91.01.3-0.9-1.00.90.9-0.9-1.11.1-1.1
Delay disc. indifference point, 16s delay0.00.00.20.5-0.10.10.1-0.1-0.3-0.20.1
Delay disc. indifference point, 2s delay0.10.10.2-0.2-0.30.30.3-0.3-0.50.2-0.3
Delay disc. indifference point, 24s delay1.52.42.51.61.5-1.6-1.51.51.5-1.61.6
Delay disc. indifference point, 4s delay0.10.10.2-0.2-0.30.30.3-0.3-0.40.3-0.3
Delay disc. indifference point, 8s delay0.00.00.10.30.2-0.2-0.10.10.1-0.20.2
Indifference point function ln k0.72.02.31.11.5-1.5-1.51.41.5-1.51.5
Indifference point function log k0.72.02.31.11.5-1.5-1.51.41.5-1.51.5
Patch foraging total patch changes 0 sec0.41.11.8-1.3-1.11.01.0-1.0-0.81.0-0.9
Patch foraging total patch changes 12 sec1.21.62.6-1.6-1.31.21.2-1.2-1.21.1-1.1
Patch foraging total patch changes 18 sec0.71.62.1-1.5-1.31.21.2-1.2-1.31.2-1.2
Patch foraging total patch changes 24 sec0.51.92.1-1.3-1.41.41.4-1.4-1.41.3-1.3
Patch foraging total patch changes 6 sec1.72.93.3-1.5-1.81.71.7-1.7-1.71.7-1.7
Patch foraging time to switch 0 sec0.10.40.7-0.9-0.70.70.7-0.7-0.60.6-0.6
Patch foraging water rate 0 sec0.41.51.60.91.2-1.2-1.21.21.3-1.31.3
Patch foraging water rate 12 sec0.00.10.1-0.2-0.20.30.3-0.3-0.30.2-0.2
Patch foraging water rate 18 sec0.51.11.40.71.1-1.1-1.11.11.1-1.11.2
Patch foraging water rate 24 sec0.20.31.0-1.0-0.40.40.4-0.4-0.50.4-0.4
Patch foraging water rate 6 sec0.10.20.20.20.4-0.4-0.40.40.4-0.50.5
Seeking ratio, delayed vs. immediate footshock0.00.10.1-0.0-0.30.30.3-0.2-0.30.2-0.2
Distance traveled before self-admin0.10.20.60.80.4-0.3-0.30.30.3-0.10.2
Distance traveled after self-admin0.71.21.4-1.2-1.01.11.1-1.1-1.11.1-1.1
Extensor digitorum longus weight2.28.710.93.33.0-2.9-2.92.92.7-2.92.9
Bone: elastic displacement1.51.82.71.71.3-1.3-1.31.31.4-1.21.3
Bone: elastic work0.50.71.41.20.8-0.8-0.80.80.8-0.80.8
Bone: endosteal estimation0.10.20.30.10.4-0.4-0.40.40.5-0.40.4
Bone: endosteal perimeter0.00.00.0-0.00.0-0.1-0.10.10.1-0.10.1
Epididymis fat weight11.055.757.1-7.6-7.57.57.5-7.5-7.47.4-7.4
Delta time in closed arm before/after self-admin0.20.20.9-0.9-0.40.30.2-0.2-0.20.0-0.1
Delta time in open arm before/after self-admin0.00.00.00.0-0.00.00.1-0.1-0.10.1-0.0
Diff in mean of infusions in LGA sessions0.00.10.2-0.4-0.30.20.3-0.3-0.20.0-0.2
Delay discount exponential model param0.10.10.4-0.6-0.30.30.3-0.3-0.10.5-0.4
Extinction: sum of active levers before priming0.40.71.0-0.20.8-0.8-0.80.80.9-1.01.0
Active lever presses in extinction session 61.91.92.50.81.4-1.4-1.41.41.2-1.51.6
Bone: final force0.00.00.0-0.2-0.20.10.1-0.1-0.10.1-0.1
Bone: final moment0.00.00.0-0.1-0.10.10.1-0.1-0.10.1-0.1
Food consumed during 24 hour testing period0.00.10.10.0-0.30.30.3-0.3-0.30.3-0.3
Glucose0.81.31.4-0.9-1.21.21.2-1.2-1.21.2-1.2
Heart weight1.21.93.4-1.8-1.31.31.3-1.3-1.31.3-1.3
Delay discount hyperbolic model param0.00.00.1-0.3-0.10.10.1-0.10.10.2-0.2
Intermittent access intake day 1-15 change0.20.81.00.71.0-0.9-0.90.91.0-0.90.9
Intermittent access intake escalation0.10.30.40.40.6-0.6-0.60.60.6-0.50.6
Intermittent access intake escalation 20.00.00.0-0.10.2-0.1-0.10.10.1-0.00.1
Intermitt. access day 1 inactive lever presses0.11.41.51.21.2-1.2-1.21.21.0-1.21.2
Intermitt. access day 15 inactive lever presses0.31.92.21.51.3-1.3-1.31.31.2-1.41.5
Intermitt. access escalation Index1.96.07.1-2.7-2.52.42.4-2.4-2.42.4-2.4
Intermittent access day 1 total infusions1.54.36.82.62.1-2.0-2.02.02.0-2.11.9
Intermittent access day 15 total infusions1.43.54.12.01.9-1.8-1.81.81.9-1.91.8
Intermittent access terminal intake (last 3 days)2.74.86.02.52.2-2.1-2.12.12.2-2.22.1
Intermittent access total infusions4.85.66.82.62.4-2.3-2.32.32.3-2.42.3
Intermittent access day 1 locomotion1.73.13.31.81.8-1.8-1.81.81.8-1.71.7
Intermittent access day 15 total locomotion0.00.10.40.60.4-0.3-0.30.30.4-0.20.2
Intermittent access total locomotion1.21.51.71.01.3-1.3-1.31.21.3-1.21.2
Intermittent access standard deviation0.42.12.41.51.5-1.4-1.41.41.5-1.41.3
Left kidney weight0.10.71.0-0.00.8-0.9-0.90.91.0-1.01.0
Right kidney weight0.00.21.2-1.1-0.30.30.3-0.3-0.20.3-0.3
Cocaine induced anxiety0.00.10.1-0.30.2-0.2-0.20.20.3-0.30.3
Post-drug Anxiety1.51.72.2-1.5-1.31.31.3-1.3-1.31.2-1.2
Baseline Anxiety2.23.84.2-1.4-2.02.02.0-2.0-2.02.0-2.0
Tail length0.00.00.2-0.40.0-0.1-0.10.10.1-0.30.2
Length with tail0.10.52.0-1.4-0.60.50.5-0.5-0.50.2-0.4
Length without tail0.00.10.9-1.0-0.10.0-0.00.00.0-0.20.2
Times rat made contact with spout0.50.60.60.70.8-0.8-0.80.80.7-0.70.7
Lifetime Intake5.06.26.82.52.5-2.5-2.52.42.5-2.62.4
Liver weight, left1.83.24.1-2.0-1.71.71.7-1.7-1.81.7-1.7
Liver weight, right3.56.211.0-3.3-2.32.32.3-2.4-2.32.3-2.3
Locomotor activity0.60.91.5-1.2-0.90.90.9-0.9-0.81.0-0.9
Locomotor testing distance0.20.50.6-0.7-0.70.70.7-0.7-0.60.7-0.7
Locomotor testing rearing0.10.50.60.50.7-0.7-0.70.70.7-0.70.7
Locomotion in novel chamber0.10.10.1-0.3-0.20.20.2-0.2-0.30.3-0.3
Locomotion in novel chamber post-restriction1.34.05.3-2.3-2.02.02.0-2.0-2.01.8-2.0
Fecal boli incidents, locomotor time 11.02.63.01.01.6-1.7-1.71.71.7-1.71.7
Change in fecal boli incidents, locomotor task3.33.54.0-2.0-1.91.91.9-1.9-2.01.6-1.7
Time >=10cm from walls, locomotor time 10.30.40.50.50.6-0.6-0.70.70.7-0.60.7
Bouts of movement, locomotor time 10.00.00.10.3-0.10.10.1-0.1-0.20.2-0.1
Total resting periods, locomotor time 10.00.00.10.4-0.10.00.1-0.0-0.20.20.0
Rest time, locomotor task time 10.20.30.60.1-0.50.50.5-0.5-0.60.8-0.6
Distance moved, locomotor task time 10.10.21.0-1.0-0.30.30.3-0.3-0.20.1-0.1
Vertical activity count, locomotor time 10.00.10.3-0.5-0.20.20.2-0.2-0.20.0-0.1
Time >=10cm from walls, locomotor time 20.71.92.21.51.4-1.4-1.41.41.3-1.31.3
Bouts of movement, locomotor time 20.10.40.6-0.5-0.80.70.7-0.7-0.70.6-0.5
Total resting periods, locomotor time 20.10.50.6-0.4-0.80.80.8-0.7-0.80.7-0.5
Rest time, locomotor task time 20.00.10.40.6-0.00.00.0-0.00.00.3-0.1
Distance moved, locomotor task time 20.00.00.1-0.40.1-0.0-0.10.1-0.10.00.0
Vertical activity count, locomotor time 20.10.10.2-0.00.4-0.4-0.40.40.3-0.40.4
Light reinforcement 10.21.01.20.90.9-1.0-1.01.01.0-1.11.1
Light reinforcement 20.61.41.81.31.1-1.1-1.21.21.2-1.21.2
Bone: marrow area0.10.20.30.10.4-0.4-0.40.40.5-0.40.4
Bone: maximum diameter0.00.00.1-0.3-0.0-0.0-0.00.00.1-0.00.0
Bone: maximum force0.00.00.00.20.1-0.1-0.10.10.1-0.10.1
Bone: maximum moment0.00.00.10.30.1-0.1-0.10.20.2-0.20.2
Mean time between licks in bursts0.32.13.0-1.7-1.41.41.4-1.4-1.31.4-1.4
Mean num. licks in bursts0.71.81.91.11.4-1.4-1.41.41.4-1.41.4
Cd content in liver0.00.00.2-0.4-0.20.20.2-0.2-0.00.1-0.1
Co content in liver5.56.47.02.52.5-2.5-2.52.52.7-2.62.6
Cu content in liver0.40.50.91.00.7-0.7-0.70.70.7-0.70.7
Fe content in liver1.92.32.41.61.6-1.5-1.51.51.5-1.51.5
K content in liver0.10.10.1-0.4-0.40.30.3-0.3-0.20.3-0.3
Mg content in liver0.00.00.2-0.5-0.1-0.0-0.00.10.2-0.10.1
Mn content in liver0.70.81.4-1.2-1.00.90.9-0.9-0.80.8-0.8
Na content in liver2.22.52.71.61.6-1.6-1.61.61.6-1.61.6
Rb content in liver0.10.10.6-0.8-0.40.30.3-0.3-0.20.2-0.2
Se content in liver0.10.10.2-0.4-0.40.40.4-0.4-0.30.4-0.4
Sr content in liver0.10.10.30.50.3-0.3-0.30.30.3-0.30.3
Zn content in liver0.40.40.6-0.5-0.80.70.7-0.7-0.50.6-0.6
Bone: minimum diameter0.50.91.4-1.2-1.00.90.9-0.9-0.80.8-0.9
Time in familiar zone, hab. session 10.70.81.6-1.3-0.90.80.8-0.8-0.80.8-0.8
Time in novel zone, hab. session 10.20.30.3-0.4-0.50.50.5-0.5-0.50.5-0.5
Total zone transitions, hab. session 10.10.20.20.30.4-0.4-0.40.40.4-0.40.4
Total locomotion distance, hab. session 10.60.81.00.41.0-1.0-1.01.01.0-1.01.0
Locomotion velocity, hab. session 11.21.81.91.11.4-1.4-1.41.31.4-1.41.4
Time in familiar zone, hab. session 20.30.30.4-0.5-0.60.60.6-0.6-0.60.5-0.5
Time in novel zone, hab. session 20.00.00.1-0.2-0.10.10.1-0.1-0.10.2-0.1
Total zone transitions, hab. session 20.20.20.2-0.4-0.50.50.5-0.5-0.40.5-0.5
Total locomotion distance, hab. session 20.20.30.3-0.1-0.60.60.6-0.6-0.50.6-0.5
Locomotion velocity, hab. session 20.10.10.20.1-0.40.40.4-0.4-0.40.4-0.4
Novel to familiar place preference ratio0.50.61.3-1.2-0.70.70.7-0.7-0.70.7-0.7
Novelty place preference0.81.01.9-1.4-0.90.90.9-0.9-0.91.0-0.9
Time in novel zone, NPP test0.81.02.0-1.4-0.90.90.9-0.9-0.90.9-0.9
Total zone transitions, NPP test0.91.31.71.31.1-1.1-1.11.11.2-1.11.1
Total locomotion distance, NPP test1.21.71.91.41.3-1.3-1.31.31.3-1.31.3
Locomotion velocity, NPP test1.62.32.71.71.5-1.5-1.51.51.5-1.51.5
Intraocular pressure4.47.211.6-3.4-2.52.52.5-2.5-2.62.7-2.5
Delta distance traveled before/after self-admin2.42.63.1-1.8-1.71.61.6-1.6-1.71.5-1.5
Delta ambulatory time before/after self-admin0.40.71.4-1.2-0.90.80.8-0.8-0.90.7-0.7
Parametrial fat weight18.142.744.7-5.8-6.76.76.7-6.7-6.66.5-6.7
Pavlov. Cond. lever latency0.50.60.9-1.0-0.80.80.8-0.8-0.80.8-0.7
Pavlov. Cond. magazine entry latency0.00.00.0-0.1-0.10.10.1-0.1-0.10.1-0.1
Pavlov. Cond. change in total contacts0.10.10.10.20.3-0.3-0.20.20.3-0.30.2
Pavlov. Cond. index score0.00.10.10.20.3-0.3-0.30.30.2-0.30.2
Pavlov. Cond. latency score0.00.00.00.10.1-0.1-0.10.10.1-0.10.1
Pavlov. Cond. lever contacts0.50.60.70.80.8-0.8-0.80.80.7-0.70.7
Pavlov. Cond. magazine entry number0.00.00.0-0.2-0.10.10.1-0.1-0.10.1-0.1
Pavlov. Cond. intertrial magazine entries2.22.63.01.71.6-1.6-1.61.61.6-1.61.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.40.60.6-0.6-0.60.60.6-0.60.6
Pavlov. Cond. response bias0.70.90.90.90.9-0.9-0.90.90.9-1.00.9
Pavlov. Cond. lever latency0.60.92.2-1.5-0.90.90.9-0.9-0.80.8-0.8
Pavlov. Cond. magazine entry latency0.00.10.20.5-0.20.20.2-0.2-0.30.2-0.2
Pavlov. Cond. change in total contacts0.00.10.70.80.2-0.2-0.10.20.0-0.10.1
Pavlov. Cond. index score0.30.51.71.30.6-0.6-0.50.60.5-0.50.5
Pavlov. Cond. latency score0.30.51.81.40.6-0.6-0.60.60.5-0.50.5
Pavlov. Cond. lever contacts0.40.61.51.20.7-0.7-0.70.70.6-0.60.6
Pavlov. Cond. magazine entry number0.10.10.2-0.30.4-0.4-0.40.40.4-0.40.4
Pavlov. Cond. intertrial magazine entries1.63.44.7-2.2-1.91.81.8-1.8-1.81.7-1.7
Pavlov. Cond. lever-magazine prob. diff.0.10.21.01.00.2-0.2-0.20.20.1-0.20.2
Pavlov. Cond. response bias0.60.82.31.50.8-0.8-0.80.80.7-0.70.7
Time in closed arm before self-admin0.30.50.8-0.8-0.60.60.6-0.7-0.60.9-0.8
Time in closed arm after self-admin1.01.21.7-1.3-1.01.01.0-1.0-1.01.1-1.2
Time in open arm before self-admin0.00.00.1-0.00.0-0.1-0.10.10.1-0.30.3
Time in open arm after self-admin0.20.20.30.40.5-0.5-0.50.50.5-0.40.5
Bone: periosteal estimation0.10.20.30.10.4-0.5-0.50.50.5-0.50.5
Bone: periosteal perimeter0.00.00.00.00.0-0.1-0.10.10.1-0.10.1
Bone: post-yield work1.62.83.21.51.6-1.7-1.71.71.8-1.71.7
Progressive ratio test 1 active lever presses2.13.84.02.02.0-1.9-1.91.91.9-2.01.9
Progressive ratio test 1 breakpoint2.23.94.12.02.0-2.0-2.01.91.9-2.01.9
Progressive ratio test 1 inactive lever presses2.56.67.02.42.6-2.6-2.62.62.5-2.62.6
Progressive ratio test 2 active lever presses2.63.74.21.82.0-1.9-1.91.91.9-2.02.0
Progressive ratio test 2 breakpoint2.73.53.91.71.9-1.9-1.91.91.9-2.01.9
Progressive ratio test 2 inactive lever presses1.44.44.71.92.2-2.1-2.12.12.0-2.22.1
Incentive Sensitization - Responses1.02.63.21.11.6-1.7-1.71.71.7-1.81.8
Incentive Sensitization - Breakpoint0.92.02.50.91.4-1.4-1.51.51.5-1.61.5
Sum of active levers in priming session hrs 5-60.20.20.7-0.9-0.50.40.4-0.4-0.4-0.1-0.2
Progressive ratio0.00.00.0-0.2-0.20.20.2-0.2-0.20.1-0.2
Food seeking constrained by brief footshock12.916.118.02.84.0-4.1-4.14.24.2-4.24.2
Seeking ratio, punishment vs. effort1.02.12.51.11.5-1.5-1.51.51.5-1.41.6
Retroperitoneal fat weight31.7142.0145.5-11.4-12.112.012.0-12.0-12.011.8-11.9
Reaction time number correct0.10.20.40.70.5-0.4-0.40.40.4-0.40.4
Reaction time mean minus median0.00.10.30.6-0.00.10.1-0.1-0.10.2-0.1
Reaction time mean minus median AUC0.00.10.20.1-0.40.40.4-0.4-0.30.4-0.3
Reaction time num false alarms1.42.52.9-1.7-1.71.61.6-1.6-1.51.5-1.5
Reaction time num false alarms AUC1.12.63.0-1.7-1.71.61.6-1.6-1.51.6-1.6
Reaction time trials correct on left0.10.20.40.70.5-0.4-0.40.40.4-0.40.4
Reaction time trials on left0.10.20.40.60.4-0.4-0.40.40.4-0.40.4
Reaction time mean0.00.10.2-0.4-0.20.20.2-0.2-0.30.3-0.2
Reaction time mean AUC0.00.00.1-0.4-0.10.10.1-0.1-0.20.2-0.1
Median of all reaction times0.00.10.3-0.6-0.10.10.1-0.1-0.10.2-0.1
Reaction time omissions0.10.20.5-0.7-0.40.50.5-0.5-0.50.4-0.4
Reaction time false alarm rate2.23.13.5-1.8-1.91.81.8-1.8-1.61.7-1.7
Reaction time premature initiation rate0.10.10.2-0.0-0.40.40.4-0.4-0.30.4-0.4
Reaction time premature initiations0.00.00.10.2-0.10.10.1-0.1-0.10.1-0.1
Std. dev. reaction times0.10.30.5-0.1-0.40.50.5-0.6-0.50.7-0.6
Reaction time trials completed0.10.20.40.60.4-0.4-0.40.40.4-0.40.4
Reaction time trials AUC0.10.30.60.80.5-0.5-0.50.50.5-0.50.4
Run reversals in cocaine runway, females0.50.60.80.90.8-0.8-0.80.70.7-0.70.6
Run reversals in cocaine runway, males0.80.91.00.91.0-1.0-1.01.00.9-0.80.9
Latency to leave start box in cocaine runway0.70.92.21.50.9-0.8-0.80.80.8-1.00.8
Latency to leave start box in cocaine runway, F0.10.20.50.70.3-0.3-0.30.30.3-0.40.3
Latency to leave start box in cocaine runway, M0.90.91.81.30.9-0.9-0.90.90.8-0.80.8
Std. dev. time between licks in bursts0.71.32.3-1.5-1.11.11.1-1.1-1.11.1-1.1
Total sessions with >9 infusions2.53.13.81.71.8-1.7-1.81.71.9-1.81.6
Short access day 1 total inactive lever presses3.26.37.52.02.7-2.6-2.62.62.7-2.52.4
Short access day 10 total inactive lever presses0.21.11.61.31.1-1.1-1.11.11.0-0.81.0
Short access day 1 total infusions2.75.46.32.22.4-2.3-2.32.32.5-2.52.1
Short access day 10 total infusions3.55.76.12.42.5-2.4-2.42.42.4-2.42.3
Short access total infusions2.63.64.51.62.0-1.9-1.91.92.0-2.11.8
Short access day 1 locomotion2.03.34.62.21.9-1.8-1.81.81.9-1.61.6
Short access day 10 total locomotion0.52.22.81.51.5-1.5-1.51.51.7-1.31.4
Short access total locomotion0.91.41.80.91.2-1.2-1.21.21.3-1.11.1
One hour access (0.3 mA shock)2.83.34.32.12.0-1.8-1.81.81.7-1.81.7
Compulsive drug intake2.23.24.0-2.0-1.71.71.7-1.8-1.71.9-1.8
One hour access (shock baseline)2.77.18.02.82.7-2.7-2.72.62.5-2.82.7
Social response proportion0.00.10.10.30.3-0.2-0.20.20.3-0.20.2
Social responses0.10.20.30.0-0.50.50.5-0.5-0.30.4-0.4
Social time0.00.10.10.00.2-0.2-0.20.20.4-0.30.2
Soleus weight2.98.710.13.23.0-2.9-2.92.92.9-2.92.9
Bone: stiffness0.00.10.1-0.2-0.30.20.2-0.2-0.30.2-0.2
Tibialis anterior weight1.03.46.42.51.8-1.8-1.71.71.7-1.71.7
Time to tail flick, vehicle, before self-admin0.00.00.1-0.3-0.10.00.0-0.0-0.2-0.10.1
Time to tail flick, vehicle, after self-admin2.65.26.3-1.6-2.22.42.4-2.4-2.32.3-2.5
Time to tail flick, test, before self-admin0.10.10.2-0.10.4-0.4-0.40.40.4-0.30.3
Time to tail flick, test, after self-admin1.31.42.10.71.2-1.2-1.21.21.1-1.51.2
Delta time to tail flick, vehicle, before/after SA1.61.72.4-0.6-1.31.41.4-1.4-1.31.4-1.5
Delta time to tail flick, test, before/after SA2.22.83.41.61.6-1.6-1.61.61.7-1.81.6
Tibia length0.92.66.9-2.6-1.51.51.4-1.5-1.31.3-1.3
Ambulatory time before self-admin0.10.20.60.80.5-0.4-0.40.40.4-0.20.3
Ambulatory time after self-admin0.20.40.7-0.8-0.60.60.6-0.6-0.60.6-0.6
Bone: tissue strength0.60.60.7-0.5-0.80.80.8-0.8-0.80.8-0.8
Total heroin consumption2.12.42.81.21.6-1.6-1.61.61.5-1.71.7
Bone: trabecular number1.93.63.81.71.9-1.9-1.91.91.9-1.91.9
Bone: trabecular spacing0.60.91.7-1.3-0.90.90.9-0.9-0.90.9-0.9
Bone: trabecular thickness0.30.40.40.50.6-0.6-0.60.60.6-0.60.6
Bone: trabecular tissue density0.20.40.50.70.7-0.6-0.60.60.7-0.60.5
Water consumed over 24 hours0.20.30.4-0.1-0.60.60.6-0.6-0.70.6-0.6
Number of responses in last shaping day1.31.72.20.51.3-1.3-1.41.31.3-1.51.4