LOC102548914

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC102548914	0.03	0.03	1.9e-03	0.02	0.02	0.02	0.02	9.6e-04	1.5e-03	1.0e-03	2.5e-03
2	PL	gene expression	LOC102548914	0.03	0.03	2.8e-04	0.02	0.03	0.02	0.02	3.5e-03	8.8e-04	1.1e-03	2.3e-03
3	BLA	gene expression	LOC102548914	0.09	0.09	2.4e-03	0.05	0	0	0.04	1.3e-03	1.8e-01	1.8e-01	4.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	5.4	9.0	9.7	3.1	-3.1	2.8
Area under the delay curve	0.0	0.0	0.1	0.2	-0.3	-0.1
BMI with tail	0.5	1.5	1.9	-1.2	1.1	-1.4
BMI without tail	0.3	0.5	0.7	-0.8	0.7	-0.7
Body weight	1.9	7.9	8.7	-2.9	2.8	-2.7
Weight adjusted by age	0.0	0.0	0.1	0.1	0.1	0.3
Bone surface	2.9	5.0	5.1	2.3	-2.3	2.2
Bone volume	3.0	5.0	5.2	2.3	-2.3	2.2
Breakpoint value in progressive ratio session	1.2	1.4	2.0	1.0	-1.0	1.4
Number of licking bursts	0.2	0.2	0.4	0.6	-0.3	0.2
Context. condit. distance diff. score	0.0	0.0	0.1	-0.3	0.1	-0.1
Locomotion velocity, session 1	0.0	0.0	0.0	-0.1	0.1	-0.2
Locomotion distance, session 1	1.9	2.4	2.8	1.6	-1.7	1.4
Locomotion velocity, session 2	0.2	0.3	0.3	-0.6	0.4	-0.6
Locomotion distance, session 2	0.0	0.0	0.0	-0.0	-0.0	-0.0
Locomotion velocity, session 3	0.6	0.7	0.8	0.7	-0.8	0.9
Locomotion distance, session 3	0.9	1.0	1.2	1.1	-1.0	0.9
Stereotopy head waving bouts, day 3	1.8	2.1	2.4	1.4	-1.4	1.5
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.2	-0.3	0.5
Locomotion velocity, session 7	1.1	1.2	1.4	1.1	-1.1	1.2
Locomotion distance, session 7	0.0	0.1	0.1	0.1	-0.2	0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.0	0.1	-0.2
Stereotopy head waving duration, day 7	0.4	0.5	0.5	0.7	-0.6	0.7
Locomotion velocity, session 8	0.2	0.3	0.5	0.4	-0.4	0.7
Locomotion distance, session 8	0.3	0.4	0.5	0.4	-0.7	0.7
Degree of sensitization distance	0.9	0.9	1.1	-1.1	0.9	-0.8
Degree of sensitization stereotypy	0.1	0.2	0.3	-0.2	0.4	-0.5
Conditioned locomotion	3.0	3.5	3.8	1.8	-1.9	1.9
Cocaine response after cond. corrected	0.8	0.9	1.3	0.8	-1.1	0.9
Cocaine response after cond. not corrected	1.9	2.1	2.5	1.4	-1.6	1.3
Cocaine response before conditioning	1.4	1.7	2.4	1.6	-1.1	1.2
Saline control response	0.7	0.9	1.0	1.0	-1.0	0.9
Bone: connectivity density	5.3	8.3	8.9	3.0	-2.9	2.7
Bone: cortical apparent density	0.4	0.5	0.8	0.9	-0.7	0.6
Bone: cortical area	0.3	0.5	0.5	0.7	-0.7	0.7
Bone: cortical porosity	1.4	1.6	1.7	1.3	-1.2	1.3
Bone: cortical porosity	1.2	1.3	1.5	1.2	-1.1	1.1
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.1	-0.2
Bone: cortical thickness	1.6	1.9	2.0	1.4	-1.4	1.4
Bone: cortical tissue density	0.3	0.4	0.6	0.8	-0.6	0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	0.6	-0.8	0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.7	0.7	0.8	-0.9	0.9	-0.9
Condit. Reinf. active responses	0.2	0.2	0.3	0.6	-0.5	0.4
Condit. Reinf. inactive responses	1.8	2.2	2.4	1.6	-1.5	1.3
Incentive salience index mean	0.0	0.0	0.1	0.3	-0.2	0.2
Condit. Reinf. lever presses	0.7	0.9	1.2	1.1	-0.9	0.8
Condit. Reinf. active minus inactive responses	3.9	4.9	5.1	2.3	-2.2	2.1
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.2	1.1	-1.1	1.0
Condit. Reinf. active responses	3.3	4.6	5.2	2.3	-2.1	2.0
Condit. Reinf. inactive responses	1.8	2.3	2.5	1.6	-1.5	1.5
Condit. Reinf. lever presses	2.0	2.7	2.9	1.7	-1.7	1.6
Condit. Reinf. lever reinforcers received	2.9	4.0	4.6	2.1	-1.9	1.9
Conditioned reinforcement - actives	1.1	1.1	2.0	0.7	-0.8	1.4
Conditioned reinforcement - inactives	3.2	3.6	4.4	2.1	-1.8	1.7
Conditioned locomotion	0.3	0.3	1.0	0.0	0.0	1.0
Patch foraging indifference point 0 sec	0.3	0.4	0.6	-0.6	0.8	-0.6
Patch foraging indifference point AUC	2.5	2.9	3.1	1.7	-1.7	1.7
Delay disc. indifference point, 0s delay	2.8	3.1	3.9	-1.6	1.6	-2.0
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	0.5	-0.6	0.1
Delay disc. indifference point, 2s delay	0.2	0.3	0.4	-0.6	0.5	-0.5
Delay disc. indifference point, 24s delay	1.4	1.4	1.8	1.3	-1.3	0.8
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	0.1	-0.1	-0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.4	-0.4	0.1
Indifference point function ln k	0.0	0.0	0.0	-0.2	0.2	-0.0
Indifference point function log k	0.0	0.0	0.0	-0.2	0.2	-0.0
Patch foraging total patch changes 0 sec	0.2	0.3	0.4	-0.4	0.7	-0.5
Patch foraging total patch changes 12 sec	0.6	0.8	1.0	-0.8	1.0	-0.9
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.0	0.1	0.2
Patch foraging total patch changes 24 sec	0.7	0.9	1.0	-0.9	1.0	-0.8
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.0	0.2	-0.3
Patch foraging time to switch 0 sec	0.0	0.1	0.2	-0.1	-0.0	-0.4
Patch foraging water rate 0 sec	0.1	0.1	0.3	0.1	0.1	0.6
Patch foraging water rate 12 sec	1.6	2.4	2.7	-1.6	1.6	-1.4
Patch foraging water rate 18 sec	0.6	0.9	0.9	-1.0	1.0	-0.9
Patch foraging water rate 24 sec	2.0	2.8	3.6	-1.9	1.7	-1.4
Patch foraging water rate 6 sec	1.3	1.9	2.1	-1.5	1.4	-1.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.4	0.2	-0.0
Distance traveled before self-admin	0.0	0.0	0.1	-0.3	-0.2	0.1
Distance traveled after self-admin	1.0	1.1	1.8	-1.3	0.8	-1.0
Extensor digitorum longus weight	4.6	18.1	18.7	4.3	-4.3	4.2
Bone: elastic displacement	0.8	0.9	1.0	0.9	-0.9	1.0
Bone: elastic work	1.1	1.5	1.5	1.2	-1.2	1.2
Bone: endosteal estimation	0.4	1.0	1.1	0.9	-0.9	1.1
Bone: endosteal perimeter	0.1	0.3	0.3	0.5	-0.6	0.6
Epididymis fat weight	14.3	33.2	36.0	-5.9	6.0	-5.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.3	0.2	-0.1
Delta time in open arm before/after self-admin	0.3	0.3	0.4	0.4	-0.6	0.6
Diff in mean of infusions in LGA sessions	0.4	0.4	0.6	0.6	-0.4	0.8
Delay discount exponential model param	0.2	0.2	0.4	-0.5	0.6	-0.2
Extinction: sum of active levers before priming	0.5	0.5	0.6	0.8	-0.7	0.6
Active lever presses in extinction session 6	0.4	0.4	0.9	0.3	-0.4	1.0
Bone: final force	0.1	0.2	0.3	0.3	-0.4	0.6
Bone: final moment	0.2	0.2	0.4	0.3	-0.5	0.6
Food consumed during 24 hour testing period	0.3	0.3	0.4	0.7	-0.6	0.6
Glucose	0.2	0.3	0.4	-0.5	0.6	-0.5
Heart weight	9.7	13.8	14.5	-3.7	3.6	-3.8
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.4	0.6	-0.3
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.3	-0.3	0.3
Intermittent access intake escalation	0.0	0.0	0.0	-0.0	-0.1	0.1
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.5	0.4	-0.6
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	0.4	-0.4	0.3
Intermitt. access day 15 inactive lever presses	8.1	8.9	9.2	2.9	-3.0	3.0
Intermitt. access escalation Index	0.2	0.1	0.2	-0.5	0.3	-0.3
Intermittent access day 1 total infusions	5.5	6.4	7.4	2.7	-2.5	2.4
Intermittent access day 15 total infusions	2.4	2.6	3.0	1.7	-1.6	1.5
Intermittent access terminal intake (last 3 days)	1.8	1.9	2.1	1.4	-1.4	1.4
Intermittent access total infusions	2.3	2.5	2.9	1.7	-1.5	1.6
Intermittent access day 1 locomotion	2.1	2.2	2.5	1.6	-1.6	1.3
Intermittent access day 15 total locomotion	0.8	0.9	1.3	1.1	-0.8	0.8
Intermittent access total locomotion	0.4	0.4	0.6	0.8	-0.5	0.6
Intermittent access standard deviation	0.2	0.2	0.3	0.4	-0.3	0.6
Left kidney weight	0.0	0.0	0.0	-0.1	0.1	-0.1
Right kidney weight	1.0	2.8	3.3	-1.5	1.7	-1.8
Cocaine induced anxiety	0.4	0.4	0.5	0.7	-0.6	0.6
Post-drug Anxiety	0.8	0.9	1.6	-0.7	0.8	-1.3
Baseline Anxiety	1.6	1.7	2.1	-1.3	1.1	-1.5
Tail length	0.1	0.3	0.4	-0.7	0.7	-0.3
Length with tail	1.5	5.4	6.4	-2.5	2.4	-2.1
Length without tail	0.7	1.4	1.5	-1.2	1.2	-1.2
Times rat made contact with spout	2.3	2.6	2.9	1.6	-1.6	1.7
Lifetime Intake	3.2	3.6	3.9	2.0	-1.7	2.0
Liver weight, left	1.1	1.8	2.0	-1.2	1.4	-1.4
Liver weight, right	9.1	15.1	15.4	-3.9	3.9	-3.9
Locomotor activity	0.2	0.3	0.4	-0.4	0.5	-0.7
Locomotor testing distance	0.1	0.1	0.2	0.3	-0.4	0.3
Locomotor testing rearing	0.7	1.1	1.9	0.7	-0.9	1.4
Locomotion in novel chamber	1.3	1.6	2.6	-1.6	1.2	-1.0
Locomotion in novel chamber post-restriction	2.2	2.6	2.8	-1.7	1.7	-1.5
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	0.3	-0.6	0.4
Change in fecal boli incidents, locomotor task	4.3	4.1	4.4	-2.0	2.1	-2.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.3	0.2	-0.2
Bouts of movement, locomotor time 1	2.2	2.4	3.0	1.5	-1.7	1.5
Total resting periods, locomotor time 1	2.5	2.8	3.3	1.6	-1.8	1.6
Rest time, locomotor task time 1	0.1	0.1	0.1	0.3	-0.2	0.3
Distance moved, locomotor task time 1	1.3	1.5	1.7	-1.3	1.1	-1.2
Vertical activity count, locomotor time 1	0.6	0.7	0.8	-0.9	0.7	-0.9
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	0.4	-0.2	0.6
Bouts of movement, locomotor time 2	0.2	0.2	0.3	-0.5	0.3	-0.5
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	-0.0	-0.2
Rest time, locomotor task time 2	1.6	1.8	2.4	1.5	-1.4	1.1
Distance moved, locomotor task time 2	0.9	1.1	1.3	-1.1	1.1	-0.9
Vertical activity count, locomotor time 2	0.5	0.5	0.8	-0.9	0.8	-0.4
Light reinforcement 1	4.0	7.4	8.3	2.8	-2.9	2.4
Light reinforcement 2	3.6	4.8	5.6	2.3	-2.4	1.8
Bone: marrow area	0.5	1.0	1.2	1.0	-1.0	1.1
Bone: maximum diameter	0.9	1.7	1.8	1.3	-1.3	1.2
Bone: maximum force	0.0	0.0	0.1	0.0	-0.2	0.3
Bone: maximum moment	0.0	0.1	0.1	0.1	-0.3	0.4
Mean time between licks in bursts	2.5	3.4	3.5	-1.8	1.9	-1.9
Mean num. licks in bursts	0.1	0.1	0.3	0.1	-0.4	0.5
Cd content in liver	0.0	0.0	0.0	-0.0	-0.1	0.0
Co content in liver	5.8	6.8	7.1	2.7	-2.6	2.6
Cu content in liver	0.0	0.0	0.0	0.1	-0.2	0.2
Fe content in liver	0.0	0.0	0.1	-0.3	0.2	-0.0
K content in liver	0.1	0.1	0.1	-0.3	0.2	-0.3
Mg content in liver	0.2	0.2	0.3	-0.5	0.4	-0.5
Mn content in liver	0.6	0.7	1.0	0.7	-0.8	1.0
Na content in liver	0.4	0.4	0.5	0.5	-0.7	0.6
Rb content in liver	0.0	0.0	0.1	-0.3	0.1	-0.2
Se content in liver	0.4	0.5	0.7	-0.8	0.7	-0.5
Sr content in liver	0.1	0.1	0.2	-0.2	0.2	-0.4
Zn content in liver	1.4	1.5	1.8	-1.3	1.2	-1.1
Bone: minimum diameter	0.0	0.1	0.1	-0.3	0.4	-0.2
Time in familiar zone, hab. session 1	0.7	0.7	0.9	-1.0	0.8	-0.7
Time in novel zone, hab. session 1	0.7	0.7	0.8	-0.8	0.9	-0.8
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.3	-0.4	0.4
Total locomotion distance, hab. session 1	0.2	0.3	0.4	0.5	-0.4	0.6
Locomotion velocity, hab. session 1	1.1	1.6	1.7	1.3	-1.2	1.2
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.2	-0.1	0.2
Time in novel zone, hab. session 2	0.5	0.5	0.6	-0.6	0.7	-0.8
Total zone transitions, hab. session 2	0.1	0.1	0.1	0.4	-0.4	0.4
Total locomotion distance, hab. session 2	0.3	0.4	0.4	0.6	-0.6	0.6
Locomotion velocity, hab. session 2	0.5	0.7	0.8	0.9	-0.8	0.8
Novel to familiar place preference ratio	1.0	1.0	1.4	-0.9	1.0	-1.2
Novelty place preference	1.7	1.7	2.1	-1.2	1.3	-1.4
Time in novel zone, NPP test	2.0	2.0	2.4	-1.3	1.4	-1.5
Total zone transitions, NPP test	1.4	2.0	2.2	1.4	-1.5	1.4
Total locomotion distance, NPP test	2.0	2.8	2.9	1.7	-1.7	1.6
Locomotion velocity, NPP test	3.4	4.9	5.1	2.3	-2.2	2.1
Intraocular pressure	5.4	7.5	8.2	-2.6	2.7	-2.9
Delta distance traveled before/after self-admin	1.4	1.5	1.6	-1.3	1.2	-1.2
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	-0.5	0.5	-0.5
Parametrial fat weight	6.2	12.0	12.8	-3.5	3.3	-3.6
Pavlov. Cond. lever latency	2.0	2.5	2.8	-1.7	1.6	-1.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.2	0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	-0.2	0.2
Pavlov. Cond. index score	0.8	1.0	1.1	1.1	-1.0	0.9
Pavlov. Cond. latency score	0.8	1.0	1.1	1.0	-1.0	0.9
Pavlov. Cond. lever contacts	1.2	1.5	1.7	1.3	-1.2	1.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.6	-0.7	0.8	-0.7
Pavlov. Cond. intertrial magazine entries	1.4	1.6	2.1	1.5	-1.2	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	2.2	1.5	-1.5	1.4
Pavlov. Cond. response bias	1.5	1.8	1.9	1.3	-1.4	1.3
Pavlov. Cond. lever latency	1.8	2.5	2.7	-1.6	1.6	-1.5
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.8	-0.6	0.6
Pavlov. Cond. change in total contacts	0.8	1.1	1.3	1.2	-1.0	1.0
Pavlov. Cond. index score	1.3	1.6	1.9	1.4	-1.2	1.2
Pavlov. Cond. latency score	1.2	1.5	1.8	1.3	-1.2	1.2
Pavlov. Cond. lever contacts	0.9	1.3	1.5	1.2	-1.1	1.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.2	-0.5	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	3.6	4.6	4.7	-2.1	2.2	-2.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.5	1.2	-1.0	1.1
Pavlov. Cond. response bias	1.8	2.4	2.8	1.7	-1.6	1.4
Time in closed arm before self-admin	0.4	0.5	0.6	-0.8	0.8	-0.4
Time in closed arm after self-admin	1.5	1.5	2.0	-1.4	1.3	-0.9
Time in open arm before self-admin	0.2	0.2	0.3	0.5	-0.2	-0.4
Time in open arm after self-admin	2.0	2.2	2.9	1.7	-1.7	1.0
Bone: periosteal estimation	0.7	1.3	1.4	1.2	-1.2	1.2
Bone: periosteal perimeter	0.2	0.3	0.4	0.6	-0.6	0.6
Bone: post-yield work	0.4	0.6	0.8	0.6	-0.8	0.9
Progressive ratio test 1 active lever presses	1.9	1.9	2.4	1.5	-1.1	1.5
Progressive ratio test 1 breakpoint	1.6	1.7	2.1	1.4	-1.0	1.4
Progressive ratio test 1 inactive lever presses	3.8	4.2	5.5	1.9	-1.8	2.4
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.2	-0.1	0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.3	-0.2	0.4
Progressive ratio test 2 inactive lever presses	2.1	2.4	2.7	1.5	-1.4	1.6
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.3	0.3	-0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.3	-0.5	0.4	-0.6
Sum of active levers in priming session hrs 5-6	0.9	0.9	1.2	1.1	-1.0	0.6
Progressive ratio	0.1	0.1	0.2	-0.1	0.1	0.5
Food seeking constrained by brief footshock	4.3	5.3	6.5	2.3	-2.0	2.5
Seeking ratio, punishment vs. effort	0.6	0.8	1.1	1.1	-0.9	0.6
Retroperitoneal fat weight	21.7	71.3	73.6	-8.6	8.5	-8.2
Reaction time number correct	0.6	0.8	0.9	0.9	-0.9	0.9
Reaction time mean minus median	0.0	0.0	0.0	0.1	0.1	0.1
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.0	0.3	-0.1
Reaction time num false alarms	0.1	0.1	0.3	0.5	-0.4	-0.1
Reaction time num false alarms AUC	0.2	0.3	0.5	0.7	-0.5	-0.1
Reaction time trials correct on left	0.6	0.8	0.9	0.9	-0.9	0.9
Reaction time trials on left	0.6	0.9	0.9	0.9	-1.0	0.9
Reaction time mean	1.1	1.6	2.0	-1.0	1.3	-1.4
Reaction time mean AUC	1.0	1.3	1.8	-0.8	1.2	-1.3
Median of all reaction times	1.3	1.8	2.5	-1.1	1.3	-1.6
Reaction time omissions	0.1	0.2	0.3	0.6	-0.3	0.3
Reaction time false alarm rate	0.1	0.1	0.3	0.2	0.1	-0.5
Reaction time premature initiation rate	0.2	0.3	0.4	-0.4	0.5	-0.6
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.1	-0.1
Std. dev. reaction times	0.2	0.3	0.5	-0.4	0.7	-0.6
Reaction time trials completed	0.6	0.9	0.9	0.9	-1.0	0.9
Reaction time trials AUC	0.8	1.1	1.2	1.0	-1.1	1.0
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.0	0.2	-0.4
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.4	-0.4	0.4
Latency to leave start box in cocaine runway	0.5	0.6	0.7	0.8	-0.7	0.7
Latency to leave start box in cocaine runway, F	0.7	0.8	1.3	1.1	-0.8	0.7
Latency to leave start box in cocaine runway, M	0.6	0.5	1.1	0.4	-0.6	1.0
Std. dev. time between licks in bursts	0.1	0.1	0.1	-0.3	0.2	-0.3
Total sessions with >9 infusions	2.6	2.9	4.4	1.6	-1.3	2.1
Short access day 1 total inactive lever presses	5.4	6.0	7.6	2.8	-2.4	2.2
Short access day 10 total inactive lever presses	1.1	1.2	1.7	1.3	-1.1	0.9
Short access day 1 total infusions	5.4	5.7	7.1	2.4	-2.1	2.7
Short access day 10 total infusions	4.3	4.8	5.4	2.3	-2.0	2.2
Short access total infusions	3.0	3.4	4.2	1.8	-1.6	2.1
Short access day 1 locomotion	6.9	7.4	9.0	2.7	-2.5	3.0
Short access day 10 total locomotion	0.7	0.8	0.9	1.0	-0.9	0.8
Short access total locomotion	0.6	0.6	0.8	0.8	-0.7	0.9
One hour access (0.3 mA shock)	1.8	2.1	2.2	1.5	-1.4	1.4
Compulsive drug intake	0.3	0.3	0.6	-0.5	0.5	-0.8
One hour access (shock baseline)	1.8	2.1	2.5	1.4	-1.3	1.6
Social response proportion	0.2	0.3	0.4	-0.5	0.7	-0.3
Social responses	0.0	0.0	0.1	0.0	0.3	-0.1
Social time	0.3	0.4	0.8	-0.6	0.9	-0.3
Soleus weight	4.4	12.9	13.6	3.7	-3.7	3.4
Bone: stiffness	0.0	0.0	0.0	-0.2	0.1	-0.1
Tibialis anterior weight	3.6	12.2	13.0	3.6	-3.6	3.3
Time to tail flick, vehicle, before self-admin	2.2	2.3	2.8	-1.5	1.7	-1.4
Time to tail flick, vehicle, after self-admin	4.1	4.4	5.1	-2.2	2.3	-1.7
Time to tail flick, test, before self-admin	0.5	0.5	0.5	0.6	-0.7	0.7
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.0	0.3	-0.1
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.4	0.1	0.1
Delta time to tail flick, test, before/after SA	0.6	0.5	0.9	0.9	-0.6	0.6
Tibia length	2.5	6.9	7.0	-2.6	2.6	-2.6
Ambulatory time before self-admin	0.1	0.1	0.2	-0.0	-0.4	0.2
Ambulatory time after self-admin	0.8	0.9	1.4	-1.2	0.7	-0.9
Bone: tissue strength	1.0	1.0	1.2	-1.0	0.9	-1.1
Total heroin consumption	3.1	3.7	4.4	2.1	-1.9	1.8
Bone: trabecular number	4.2	6.6	7.1	2.7	-2.6	2.4
Bone: trabecular spacing	3.7	4.8	5.3	-2.2	2.1	-2.3
Bone: trabecular thickness	0.9	1.1	1.3	1.0	-0.9	1.1
Bone: trabecular tissue density	0.1	0.2	0.2	0.4	-0.5	0.4
Water consumed over 24 hours	1.8	2.2	2.7	1.7	-1.5	1.3
Number of responses in last shaping day	0.5	0.5	0.8	0.6	-0.5	0.9