LOC102548914

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC102548914	0.05	0.04	1.2e-04	0.05	0.05	0.05	0.05	5.9e-05	8.6e-05	5.0e-05	5.2e-05
2	NAcc	gene expression	LOC102548914	0.04	0.03	1.7e-05	0.03	0.03	0.03	0.03	1.8e-05	1.3e-05	1.8e-05	1.8e-05
3	BLA	gene expression	LOC102548914	0.09	0.08	1.1e-03	0.05	0.01	0.01	0.04	1.9e-03	9.2e-02	6.6e-02	5.4e-03
4	PL	gene expression	LOC102548914	0.02	0.02	2.6e-03	0.01	0.01	0.01	0.01	2.7e-02	7.3e-03	3.8e-02	3.0e-02
5	IC	gene expression	LOC102548914	0.1	0.09	1.2e-03	0.07	0.07	0.07	0.06	5.3e-04	7.5e-04	9.9e-04	1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	4.7	8.7	9.6	3.1	-3.0	2.8	-3.0	2.9
Area under the delay curve	0.2	0.3	0.5	0.6	-0.3	0.3	-0.6	0.7
BMI with tail	0.3	1.0	1.4	-1.2	1.0	-1.2	0.9	-0.8
BMI without tail	0.4	2.3	2.6	-1.6	1.4	-1.6	1.4	-1.6
Body weight	2.2	9.7	11.7	-3.4	3.1	-3.3	3.0	-2.7
Weight adjusted by age	0.0	0.1	0.2	0.3	-0.2	0.4	-0.0	0.1
Bone surface	2.6	5.2	5.7	2.4	-2.3	2.2	-2.3	2.1
Bone volume	2.6	5.2	5.7	2.4	-2.3	2.2	-2.3	2.2
Breakpoint value in progressive ratio session	0.6	1.1	1.5	0.9	-0.9	1.2	-1.0	1.1
Number of licking bursts	0.0	0.1	0.2	0.3	-0.3	0.1	-0.4	0.4
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	-0.1
Locomotion velocity, session 1	0.1	0.1	0.5	0.0	0.0	-0.3	0.1	-0.7
Locomotion distance, session 1	1.8	2.3	2.8	1.7	-1.6	1.3	-1.6	1.4
Locomotion velocity, session 2	0.2	0.3	0.5	-0.5	0.5	-0.7	0.5	-0.5
Locomotion distance, session 2	0.0	0.0	0.1	0.2	-0.1	-0.0	-0.0	-0.3
Locomotion velocity, session 3	0.6	0.6	1.1	0.8	-0.8	1.0	-0.8	0.4
Locomotion distance, session 3	0.8	0.9	1.0	1.0	-1.0	0.9	-1.0	0.9
Stereotopy head waving bouts, day 3	1.8	2.1	2.6	1.5	-1.5	1.6	-1.4	1.3
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.3	-0.3	0.5	-0.3	0.2
Locomotion velocity, session 7	1.2	1.3	1.6	1.3	-1.2	1.2	-1.1	0.8
Locomotion distance, session 7	0.1	0.1	0.2	0.3	-0.3	0.4	-0.2	-0.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.3
Stereotopy head waving duration, day 7	0.3	0.3	0.5	0.6	-0.6	0.5	-0.6	0.7
Locomotion velocity, session 8	0.2	0.2	0.3	0.5	-0.5	0.6	-0.3	-0.3
Locomotion distance, session 8	0.3	0.4	0.5	0.7	-0.7	0.6	-0.7	0.3
Degree of sensitization distance	0.8	0.8	1.1	-0.9	0.9	-0.8	0.9	-1.1
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.4	0.5	-0.7	0.4	-0.1
Conditioned locomotion	3.1	3.6	4.1	1.9	-1.9	1.8	-1.9	2.0
Cocaine response after cond. corrected	0.6	1.0	1.3	0.9	-1.0	0.8	-1.1	1.1
Cocaine response after cond. not corrected	1.5	2.2	2.7	1.5	-1.5	1.2	-1.6	1.6
Cocaine response before conditioning	1.3	1.6	2.4	1.6	-1.3	1.1	-1.2	1.0
Saline control response	0.5	0.7	0.9	0.9	-0.9	0.9	-0.8	0.7
Bone: connectivity density	4.7	7.5	8.1	2.8	-2.8	2.6	-2.8	2.7
Bone: cortical apparent density	0.6	0.9	1.4	0.9	-0.8	0.7	-0.9	1.2
Bone: cortical area	0.7	1.2	1.5	1.0	-1.1	0.9	-1.1	1.2
Bone: cortical porosity	0.9	1.0	1.2	1.1	-1.1	1.1	-1.1	0.7
Bone: cortical porosity	1.1	1.2	1.4	1.2	-1.2	1.2	-1.1	0.8
Bone: cortical thickness	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2
Bone: cortical thickness	1.5	1.8	2.0	1.3	-1.4	1.4	-1.4	1.2
Bone: cortical tissue density	0.4	0.6	1.0	0.8	-0.7	0.6	-0.8	1.0
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	-0.8	0.8	-0.8	0.8	-0.5
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.9	-0.9	0.9	-0.8	0.8	-0.5
Condit. Reinf. active responses	0.2	0.3	0.6	0.5	-0.5	0.3	-0.5	0.7
Condit. Reinf. inactive responses	1.6	2.1	2.5	1.6	-1.5	1.2	-1.5	1.4
Incentive salience index mean	0.0	0.1	0.2	0.2	-0.1	0.1	-0.2	0.4
Condit. Reinf. lever presses	0.7	1.1	1.4	1.1	-1.0	0.9	-1.1	1.2
Condit. Reinf. active minus inactive responses	2.9	4.5	5.1	2.1	-2.1	2.0	-2.1	2.3
Condit. Reinf. active-inactive response ratio	0.6	0.9	1.3	0.9	-1.0	0.8	-1.0	1.1
Condit. Reinf. active responses	3.0	4.2	4.7	2.1	-2.0	2.0	-2.0	2.2
Condit. Reinf. inactive responses	1.5	2.2	2.4	1.6	-1.4	1.6	-1.4	1.5
Condit. Reinf. lever presses	2.0	2.9	3.3	1.6	-1.6	1.7	-1.7	1.8
Condit. Reinf. lever reinforcers received	2.7	3.8	4.2	2.0	-1.9	1.9	-1.9	2.1
Conditioned reinforcement - actives	0.3	1.3	3.3	1.0	-1.1	1.8	-0.9	0.6
Conditioned reinforcement - inactives	1.6	4.3	6.2	2.5	-2.1	1.9	-1.9	1.8
Conditioned locomotion	0.3	0.4	1.4	0.1	-0.0	0.8	0.2	-1.2
Patch foraging indifference point 0 sec	0.2	0.6	0.7	-0.7	0.9	-0.7	0.9	-0.6
Patch foraging indifference point AUC	0.7	1.7	2.3	1.4	-1.5	1.1	-1.4	1.0
Delay disc. indifference point, 0s delay	2.3	2.6	3.2	-1.5	1.8	-1.8	1.6	-1.4
Delay disc. indifference point, 16s delay	0.2	0.3	0.6	0.4	-0.3	0.0	-0.6	0.8
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	-0.3	0.4	-0.3	0.3	-0.7
Delay disc. indifference point, 24s delay	1.3	2.1	5.1	1.2	-1.1	0.8	-1.5	2.2
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.3	-0.1	0.1	-0.2	0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.3	-0.2	0.2	-0.5	0.6
Indifference point function ln k	0.0	0.0	0.1	0.0	0.0	0.4	0.0	-0.1
Indifference point function log k	0.0	0.0	0.1	0.0	0.0	0.4	0.0	-0.1
Patch foraging total patch changes 0 sec	0.2	0.5	0.6	-0.6	0.8	-0.6	0.8	-0.6
Patch foraging total patch changes 12 sec	0.9	1.2	1.3	-1.1	1.1	-1.1	1.1	-1.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.3	0.3	-0.2	0.3	-0.5
Patch foraging total patch changes 24 sec	0.4	1.4	2.1	-1.1	1.1	-1.0	1.2	-1.4
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.2	0.4	-0.5	0.4	-0.2
Patch foraging time to switch 0 sec	0.0	0.0	0.1	-0.2	0.2	-0.2	0.0	0.4
Patch foraging water rate 0 sec	0.0	0.1	0.1	0.1	-0.1	0.3	0.1	-0.4
Patch foraging water rate 12 sec	0.5	2.2	2.4	-1.5	1.5	-1.3	1.5	-1.4
Patch foraging water rate 18 sec	0.4	0.9	1.0	-0.9	1.0	-1.0	1.0	-1.0
Patch foraging water rate 24 sec	2.1	3.0	4.1	-2.0	1.9	-1.4	1.8	-1.5
Patch foraging water rate 6 sec	1.2	1.8	1.9	-1.3	1.3	-1.4	1.4	-1.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.9	-0.1	0.2	-0.2	0.4	-1.4
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	0.0	-0.2	-0.0	0.4
Distance traveled after self-admin	1.2	2.2	2.9	-1.7	1.5	-1.6	1.4	-1.1
Extensor digitorum longus weight	4.5	17.8	18.3	4.2	-4.2	4.1	-4.3	4.2
Bone: elastic displacement	0.6	0.7	1.1	0.7	-0.7	1.1	-0.8	0.9
Bone: elastic work	1.1	1.4	2.1	1.1	-1.1	1.2	-1.1	1.4
Bone: endosteal estimation	0.7	1.6	1.9	1.2	-1.3	1.4	-1.2	1.2
Bone: endosteal perimeter	0.3	0.7	1.0	0.7	-0.8	0.9	-0.8	1.0
Epididymis fat weight	11.2	56.6	63.3	-8.0	7.7	-7.1	7.6	-7.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.0	-0.1	0.2	-0.1	0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.4	-0.3	0.4	-0.4	0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.2	0.2	-0.1	0.4	-0.1	-0.1
Delay discount exponential model param	0.5	0.7	1.0	-0.8	0.6	-0.6	0.9	-1.0
Extinction: sum of active levers before priming	0.2	0.3	0.5	0.4	-0.6	0.6	-0.7	0.5
Active lever presses in extinction session 6	0.4	0.4	1.0	0.5	-0.6	1.0	-0.5	0.1
Bone: final force	0.1	0.2	0.2	0.3	-0.4	0.5	-0.4	0.4
Bone: final moment	0.1	0.2	0.3	0.4	-0.5	0.5	-0.5	0.4
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.5	-0.5	0.3	-0.5	0.4
Glucose	0.3	0.4	0.5	-0.6	0.6	-0.6	0.7	-0.7
Heart weight	2.9	4.7	6.2	-2.0	2.0	-2.5	2.2	-2.2
Delay discount hyperbolic model param	0.3	0.4	0.5	-0.6	0.5	-0.4	0.7	-0.7
Intermittent access intake day 1-15 change	0.0	0.1	0.3	-0.2	-0.2	0.3	0.0	-0.5
Intermittent access intake escalation	0.0	0.2	0.5	-0.5	0.1	-0.0	0.3	-0.7
Intermittent access intake escalation 2	0.2	0.3	1.2	-0.1	-0.0	-0.2	0.2	-1.1
Intermitt. access day 1 inactive lever presses	0.1	1.4	2.0	1.4	-1.2	1.3	-1.1	0.9
Intermitt. access day 15 inactive lever presses	1.3	6.9	9.0	3.0	-2.9	2.5	-2.5	2.0
Intermitt. access escalation Index	0.1	0.4	0.6	-0.7	0.5	-0.8	0.6	-0.7
Intermittent access day 1 total infusions	1.6	4.8	5.8	2.4	-2.2	2.2	-2.1	2.0
Intermittent access day 15 total infusions	0.6	1.5	2.0	1.2	-1.4	1.4	-1.2	0.8
Intermittent access terminal intake (last 3 days)	1.3	2.2	2.7	1.5	-1.7	1.6	-1.5	1.1
Intermittent access total infusions	1.7	2.1	3.1	1.3	-1.4	1.7	-1.3	1.3
Intermittent access day 1 locomotion	1.1	2.1	2.1	1.5	-1.4	1.4	-1.5	1.4
Intermittent access day 15 total locomotion	0.0	0.2	0.4	0.5	-0.4	0.6	-0.3	-0.1
Intermittent access total locomotion	0.2	0.2	0.6	0.4	-0.4	0.8	-0.3	-0.0
Intermittent access standard deviation	0.2	1.3	1.7	1.3	-1.2	1.3	-1.1	0.8
Left kidney weight	0.0	0.0	0.1	-0.3	0.2	-0.2	0.2	-0.1
Right kidney weight	0.2	1.7	2.8	-1.3	1.4	-1.7	1.2	-0.8
Cocaine induced anxiety	0.1	0.2	0.4	0.5	-0.6	0.5	-0.5	0.2
Post-drug Anxiety	1.0	1.1	1.6	-1.1	1.1	-1.2	1.1	-0.6
Baseline Anxiety	1.9	3.2	4.0	-1.8	2.0	-1.9	1.9	-1.2
Tail length	0.4	1.9	2.1	-1.4	1.3	-1.3	1.4	-1.4
Length with tail	1.9	8.3	9.7	-3.1	3.0	-2.7	2.9	-2.7
Length without tail	0.4	2.0	2.7	-1.6	1.5	-1.2	1.4	-1.2
Times rat made contact with spout	2.2	2.6	3.4	1.5	-1.5	1.5	-1.6	1.8
Lifetime Intake	1.8	2.3	3.6	1.5	-1.5	1.9	-1.4	1.2
Liver weight, left	3.7	6.4	7.0	-2.5	2.5	-2.6	2.5	-2.4
Liver weight, right	10.5	18.3	19.7	-4.3	4.2	-4.4	4.2	-4.2
Locomotor activity	0.1	0.2	0.4	-0.4	0.6	-0.6	0.4	-0.2
Locomotor testing distance	0.1	0.3	0.4	0.4	-0.4	0.6	-0.6	0.6
Locomotor testing rearing	0.3	1.0	2.3	0.7	-0.8	1.5	-0.9	0.8
Locomotion in novel chamber	0.3	0.5	1.0	-1.0	0.7	-0.2	0.7	-0.6
Locomotion in novel chamber post-restriction	1.5	4.4	5.2	-2.3	2.3	-2.0	2.1	-1.8
Fecal boli incidents, locomotor time 1	0.1	0.3	0.6	0.4	-0.5	0.4	-0.6	0.8
Change in fecal boli incidents, locomotor task	3.8	4.0	4.4	-2.1	2.1	-1.9	2.1	-1.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	0.3	-0.3	0.1	0.3
Bouts of movement, locomotor time 1	1.7	2.1	2.8	1.2	-1.5	1.3	-1.6	1.7
Total resting periods, locomotor time 1	2.2	2.5	3.3	1.3	-1.6	1.4	-1.7	1.8
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.3	0.3	-0.3	0.3	-0.4
Distance moved, locomotor task time 1	0.4	1.0	1.2	-1.1	1.1	-1.1	1.0	-0.8
Vertical activity count, locomotor time 1	0.1	0.4	0.7	-0.8	0.7	-0.7	0.6	-0.2
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.3	0.5	-0.4	0.6	-0.4	-0.1
Bouts of movement, locomotor time 2	0.0	0.1	0.1	-0.3	0.2	-0.4	0.1	-0.0
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.0	-0.2	-0.0	-0.2	0.2
Rest time, locomotor task time 2	1.0	1.6	2.1	1.5	-1.3	1.0	-1.3	1.1
Distance moved, locomotor task time 2	1.0	1.3	1.5	-1.2	1.2	-1.0	1.2	-1.1
Vertical activity count, locomotor time 2	0.3	0.7	1.0	-1.0	0.8	-0.6	0.9	-0.7
Light reinforcement 1	1.7	7.7	8.6	2.9	-2.8	2.4	-2.8	2.9
Light reinforcement 2	2.2	4.9	5.9	2.4	-2.3	1.9	-2.2	2.1
Bone: marrow area	0.6	1.6	1.9	1.2	-1.3	1.4	-1.2	1.2
Bone: maximum diameter	1.3	2.5	3.0	1.5	-1.6	1.5	-1.6	1.7
Bone: maximum force	0.1	0.3	0.4	0.4	-0.5	0.6	-0.5	0.5
Bone: maximum moment	0.2	0.4	0.4	0.5	-0.7	0.7	-0.7	0.6
Mean time between licks in bursts	0.6	3.7	3.9	-1.9	1.9	-2.0	1.9	-1.8
Mean num. licks in bursts	0.1	0.2	0.3	0.3	-0.4	0.4	-0.4	0.5
Cd content in liver	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	0.2
Co content in liver	6.4	7.5	7.8	2.7	-2.7	2.7	-2.8	2.8
Cu content in liver	0.1	0.1	0.1	0.3	-0.3	0.3	-0.3	0.2
Fe content in liver	0.7	0.8	1.3	0.9	-0.9	1.2	-0.8	0.7
K content in liver	0.4	0.4	0.6	0.7	-0.8	0.4	-0.7	0.4
Mg content in liver	0.5	0.5	0.7	0.8	-0.8	0.5	-0.8	0.6
Mn content in liver	0.1	0.1	0.2	0.2	-0.3	0.5	-0.2	-0.1
Na content in liver	0.4	0.4	0.6	0.7	-0.8	0.6	-0.7	0.4
Rb content in liver	0.0	0.0	0.1	0.1	-0.1	0.0	-0.1	0.2
Se content in liver	0.2	0.2	0.5	-0.4	0.4	-0.2	0.5	-0.7
Sr content in liver	0.2	0.1	0.2	-0.4	0.4	-0.5	0.3	-0.3
Zn content in liver	0.7	0.8	0.9	-0.9	0.9	-0.9	0.9	-0.9
Bone: minimum diameter	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2	-0.0
Time in familiar zone, hab. session 1	0.5	0.6	0.7	-0.8	0.8	-0.7	0.8	-0.7
Time in novel zone, hab. session 1	0.6	0.7	0.9	-0.9	0.9	-0.5	0.9	-1.0
Total zone transitions, hab. session 1	0.1	0.2	0.2	0.5	-0.4	0.5	-0.4	0.4
Total locomotion distance, hab. session 1	0.2	0.3	0.4	0.7	-0.5	0.6	-0.5	0.4
Locomotion velocity, hab. session 1	1.2	1.6	2.1	1.4	-1.3	1.2	-1.3	1.2
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.0	-0.1	0.2	-0.0	-0.3
Time in novel zone, hab. session 2	0.4	0.5	0.6	-0.7	0.8	-0.7	0.7	-0.4
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	-0.4	0.3	-0.4	0.4
Total locomotion distance, hab. session 2	0.2	0.3	0.4	0.7	-0.6	0.3	-0.6	0.5
Locomotion velocity, hab. session 2	0.4	0.6	0.8	0.9	-0.8	0.5	-0.8	0.8
Novel to familiar place preference ratio	0.7	0.9	1.3	-1.0	1.0	-1.1	1.0	-0.5
Novelty place preference	1.2	1.5	1.9	-1.3	1.3	-1.4	1.2	-0.8
Time in novel zone, NPP test	1.5	1.8	2.1	-1.4	1.4	-1.5	1.4	-1.0
Total zone transitions, NPP test	1.4	2.1	2.5	1.6	-1.5	1.3	-1.5	1.2
Total locomotion distance, NPP test	2.0	2.8	3.3	1.8	-1.7	1.5	-1.7	1.6
Locomotion velocity, NPP test	3.4	4.9	5.5	2.3	-2.2	2.0	-2.2	2.2
Intraocular pressure	4.6	7.5	9.0	-3.0	2.9	-2.8	2.7	-2.2
Delta distance traveled before/after self-admin	1.8	2.0	2.6	-1.5	1.3	-1.3	1.4	-1.6
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	-0.5	0.4	-0.4	0.4	-0.8
Parametrial fat weight	11.2	26.3	30.9	-5.1	5.0	-5.6	5.0	-4.9
Pavlov. Cond. lever latency	1.8	2.3	2.8	-1.7	1.6	-1.3	1.6	-1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	-0.4	0.2	-0.3	0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	-0.2	0.1	-0.2	0.2
Pavlov. Cond. index score	0.8	1.0	1.3	1.1	-1.1	0.8	-1.0	0.9
Pavlov. Cond. latency score	0.8	1.0	1.3	1.1	-1.1	0.8	-1.0	0.8
Pavlov. Cond. lever contacts	1.2	1.5	1.9	1.4	-1.3	1.1	-1.2	1.2
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	-0.9	0.9	-0.6	0.8	-0.6
Pavlov. Cond. intertrial magazine entries	1.3	1.5	1.8	1.3	-1.2	1.1	-1.2	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.2	1.5	-1.4	1.2	-1.4	1.4
Pavlov. Cond. response bias	1.4	1.8	2.1	1.4	-1.4	1.1	-1.3	1.3
Pavlov. Cond. lever latency	1.6	2.2	2.5	-1.4	1.4	-1.6	1.4	-1.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.6	0.6	-0.6	0.8	-0.5	0.3
Pavlov. Cond. change in total contacts	0.5	1.3	1.8	1.0	-1.0	1.3	-1.0	1.3
Pavlov. Cond. index score	1.1	1.7	2.3	1.2	-1.2	1.5	-1.2	1.2
Pavlov. Cond. latency score	1.0	1.7	2.4	1.2	-1.3	1.6	-1.2	1.2
Pavlov. Cond. lever contacts	1.1	1.6	2.1	1.2	-1.2	1.4	-1.2	1.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.4	0.5	-0.7	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	2.4	5.2	6.1	-2.3	2.3	-2.5	2.3	-2.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.1	1.7	1.0	-1.0	1.3	-1.0	1.0
Pavlov. Cond. response bias	1.8	2.5	3.0	1.5	-1.5	1.6	-1.5	1.7
Time in closed arm before self-admin	0.7	1.2	2.2	-0.9	1.1	-0.7	1.1	-1.5
Time in closed arm after self-admin	1.4	1.6	2.2	-1.3	1.3	-0.8	1.3	-1.5
Time in open arm before self-admin	0.2	0.3	0.8	0.3	-0.3	-0.0	-0.4	0.9
Time in open arm after self-admin	1.5	1.7	1.9	1.4	-1.3	1.0	-1.4	1.4
Bone: periosteal estimation	1.1	2.5	2.8	1.5	-1.6	1.5	-1.6	1.7
Bone: periosteal perimeter	0.5	1.0	1.5	0.9	-1.0	0.9	-1.0	1.2
Bone: post-yield work	0.7	1.2	1.6	1.0	-1.1	1.3	-1.1	1.0
Progressive ratio test 1 active lever presses	0.8	1.5	2.1	1.4	-1.1	1.4	-1.1	1.0
Progressive ratio test 1 breakpoint	0.9	1.5	2.1	1.4	-1.1	1.4	-1.1	1.1
Progressive ratio test 1 inactive lever presses	1.3	3.3	4.5	1.9	-1.9	2.1	-1.7	1.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	0.2	-0.3	0.6	-0.2	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.1	-0.2	0.5	-0.1	-0.0
Progressive ratio test 2 inactive lever presses	0.4	1.4	2.5	1.3	-1.3	1.6	-1.0	0.6
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.0	-0.3	0.3	-0.1	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.1	-0.1	0.2	0.0	-0.1
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.2	1.1	-0.9	0.4	-0.9	0.9
Progressive ratio	0.0	0.1	0.4	-0.3	0.2	0.0	0.4	-0.6
Food seeking constrained by brief footshock	2.8	3.5	5.3	2.1	-1.9	2.3	-1.7	1.2
Seeking ratio, punishment vs. effort	0.3	0.7	1.0	0.9	-0.7	0.6	-0.9	1.0
Retroperitoneal fat weight	21.0	94.0	97.9	-9.9	9.8	-9.6	9.8	-9.4
Reaction time number correct	0.3	0.9	1.0	1.0	-1.0	0.8	-1.0	1.0
Reaction time mean minus median	0.0	0.0	0.1	0.0	0.1	0.0	0.1	-0.3
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.2	0.3	-0.3	0.3	-0.4
Reaction time num false alarms	0.1	0.1	0.6	0.3	-0.1	-0.1	-0.2	0.7
Reaction time num false alarms AUC	0.1	0.2	0.8	0.4	-0.2	-0.1	-0.3	0.9
Reaction time trials correct on left	0.3	0.9	1.0	1.0	-1.0	0.8	-1.0	1.0
Reaction time trials on left	0.3	1.0	1.1	1.1	-1.0	0.9	-1.0	1.0
Reaction time mean	0.8	1.8	2.1	-1.1	1.3	-1.5	1.4	-1.4
Reaction time mean AUC	0.6	1.5	1.9	-1.0	1.2	-1.4	1.2	-1.2
Median of all reaction times	1.2	1.9	2.5	-1.2	1.4	-1.6	1.4	-1.3
Reaction time omissions	0.1	0.1	0.2	0.5	-0.3	0.2	-0.3	0.2
Reaction time false alarm rate	0.1	0.1	0.2	-0.1	0.3	-0.5	0.2	0.3
Reaction time premature initiation rate	0.1	0.2	0.3	-0.3	0.5	-0.5	0.5	-0.5
Reaction time premature initiations	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.1	0.0
Std. dev. reaction times	0.2	0.5	0.8	-0.5	0.7	-0.7	0.8	-0.9
Reaction time trials completed	0.3	1.0	1.1	1.1	-1.0	0.9	-1.0	1.0
Reaction time trials AUC	0.3	1.2	1.3	1.2	-1.1	0.9	-1.1	1.1
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.2	0.2	-0.3	0.1	0.3
Run reversals in cocaine runway, males	0.2	0.3	1.1	0.0	-0.2	0.3	-0.3	1.0
Latency to leave start box in cocaine runway	0.4	0.5	0.8	0.9	-0.7	0.9	-0.7	0.1
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	0.8	-0.5	0.5	-0.6	0.7
Latency to leave start box in cocaine runway, M	0.3	0.3	1.2	-0.0	-0.1	0.4	0.0	-1.1
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.1	0.2	-0.5	0.2	-0.3
Total sessions with >9 infusions	0.4	0.6	1.6	0.6	-0.7	1.3	-0.5	0.3
Short access day 1 total inactive lever presses	4.4	8.8	10.5	3.2	-3.1	2.9	-2.9	2.6
Short access day 10 total inactive lever presses	0.6	4.2	4.9	2.2	-2.1	1.9	-2.0	2.0
Short access day 1 total infusions	1.9	3.7	6.7	1.9	-1.9	2.6	-1.7	1.3
Short access day 10 total infusions	1.4	2.3	2.8	1.5	-1.5	1.7	-1.4	1.4
Short access total infusions	0.7	0.9	2.1	0.9	-0.9	1.4	-0.8	0.5
Short access day 1 locomotion	1.5	2.4	4.5	1.5	-1.6	2.1	-1.4	1.0
Short access day 10 total locomotion	0.4	1.8	2.3	1.5	-1.4	1.3	-1.3	1.1
Short access total locomotion	0.1	0.1	0.3	0.2	-0.2	0.6	-0.2	-0.2
One hour access (0.3 mA shock)	0.7	0.9	1.4	1.0	-1.0	1.2	-0.9	0.3
Compulsive drug intake	0.4	0.6	1.5	-0.8	0.8	-1.2	0.6	0.1
One hour access (shock baseline)	0.6	1.6	2.7	1.3	-1.4	1.6	-1.2	0.6
Social response proportion	0.4	0.5	0.9	-0.6	0.6	-0.5	0.7	-0.9
Social responses	0.1	0.1	0.2	-0.1	0.3	-0.5	0.4	-0.4
Social time	0.5	0.8	2.1	-0.6	0.7	-0.4	1.0	-1.5
Soleus weight	4.9	14.4	15.3	3.8	-3.8	3.6	-3.9	3.8
Bone: stiffness	0.0	0.0	0.0	0.1	-0.2	0.1	-0.2	0.2
Tibialis anterior weight	3.8	13.0	13.6	3.7	-3.6	3.5	-3.7	3.6
Time to tail flick, vehicle, before self-admin	1.1	1.3	1.7	-1.3	1.2	-0.8	1.3	-1.1
Time to tail flick, vehicle, after self-admin	2.3	4.8	5.6	-2.4	2.3	-1.8	2.3	-2.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.3	-0.2	0.2	-0.2	0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.4	-0.3	0.4	-0.2	-0.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.3	0.3	-0.1	0.2	-0.4
Delta time to tail flick, test, before/after SA	1.2	1.5	1.8	1.3	-1.3	1.2	-1.3	0.9
Tibia length	2.7	7.5	7.8	-2.8	2.7	-2.8	2.8	-2.6
Ambulatory time before self-admin	0.0	0.1	0.2	0.1	-0.1	-0.1	-0.2	0.5
Ambulatory time after self-admin	0.9	1.4	2.0	-1.4	1.1	-1.4	1.1	-0.9
Bone: tissue strength	0.8	0.9	1.2	-1.1	1.0	-1.1	0.9	-0.6
Total heroin consumption	3.0	3.6	3.9	1.9	-2.0	1.8	-2.0	1.7
Bone: trabecular number	3.4	6.5	7.2	2.7	-2.6	2.3	-2.5	2.6
Bone: trabecular spacing	2.9	4.3	5.0	-2.2	2.1	-2.2	2.0	-1.8
Bone: trabecular thickness	0.8	1.1	1.2	1.1	-1.1	1.1	-1.0	1.0
Bone: trabecular tissue density	0.2	0.4	0.5	0.7	-0.7	0.4	-0.7	0.5
Water consumed over 24 hours	0.4	0.8	1.0	1.0	-0.9	0.6	-0.9	0.9
Number of responses in last shaping day	0.1	0.1	0.5	-0.2	-0.2	0.7	-0.0	-0.0