Hub : Genes

LOC102547573

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	LOC102547573	0.43	0.16	2.6e-08	0.35	0.29	0.32	0.33	3.4e-09	1.2e-07	1.5e-08	8.5e-09
2	Brain	alternative polyA	XR_005499765.1	0.03	0.02	6.9e-03	0.01	0.01	0	0.01	3.2e-02	2.5e-02	2.6e-01	6.3e-02
3	Brain	alternative polyA	XR_005499762.1	0.03	0.02	6.4e-03	0.01	0.01	0	0.01	3.4e-02	2.5e-02	2.7e-01	7.6e-02
4	Brain	gene expression	LOC102547573	0.06	0.04	1.5e-04	0.03	0.03	0.04	0.04	5.6e-04	4.3e-04	1.7e-04	2.7e-04
5	PL	gene expression	LOC102547573	0.04	0.03	1.3e-04	0.01	0.03	0.02	0.02	3.4e-02	3.2e-04	1.1e-03	2.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.1	3.5	5.7	-1.9	2.4	-2.4	-1.3	0.8
Area under the delay curve	0.5	0.6	1.0	-0.5	1.0	-1.0	-0.7	0.2
BMI with tail	8.5	27.7	31.8	-5.6	5.3	-5.2	-5.0	5.1
BMI without tail	3.6	7.4	8.8	-2.9	3.0	-3.0	-2.3	2.5
Body weight	9.0	37.7	42.3	-6.5	6.2	-6.1	-5.8	6.0
Weight adjusted by age	7.4	8.4	10.0	-3.2	2.5	-2.5	-3.2	3.0
Bone surface	0.9	1.6	2.8	-1.7	1.5	-1.5	-0.6	0.7
Bone volume	3.0	5.0	6.7	-2.5	2.6	-2.6	-1.8	1.5
Breakpoint value in progressive ratio session	0.2	0.2	0.6	0.4	0.3	-0.3	0.3	-0.8
Number of licking bursts	0.4	0.4	1.0	-0.2	1.0	-1.0	-0.4	-0.0
Context. condit. distance diff. score	1.8	2.1	3.5	1.9	-1.4	1.4	1.6	-0.9
Locomotion velocity, session 1	0.1	0.2	0.3	0.1	-0.5	0.5	0.1	-0.5
Locomotion distance, session 1	0.3	0.4	0.6	-0.4	-0.6	0.6	-0.6	0.8
Locomotion velocity, session 2	0.5	0.6	1.2	0.1	-1.1	1.1	0.0	0.8
Locomotion distance, session 2	0.8	1.2	2.8	-1.3	0.3	-0.2	-1.2	1.7
Locomotion velocity, session 3	0.2	0.3	0.6	0.1	-0.6	0.6	-0.3	0.8
Locomotion distance, session 3	0.5	0.5	0.9	0.5	-0.9	0.9	-0.1	0.9
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	-0.5	0.4	-0.4	-0.6	0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.1	0.3	-0.3	-0.2	-0.5
Locomotion velocity, session 7	0.1	0.2	0.2	-0.4	0.5	-0.5	-0.1	0.3
Locomotion distance, session 7	0.1	0.1	0.3	0.4	-0.4	0.4	0.5	-0.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.3	0.2	-0.2	0.0	0.0
Stereotopy head waving duration, day 7	1.0	1.2	1.9	-1.4	1.1	-1.1	-1.0	0.7
Locomotion velocity, session 8	2.5	3.0	3.7	1.8	-1.8	1.7	1.9	-1.5
Locomotion distance, session 8	1.3	2.0	2.8	1.6	-1.7	1.7	1.2	-0.4
Degree of sensitization distance	0.9	0.9	2.4	0.7	0.0	-0.1	1.2	-1.6
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.3	0.3	-0.3	0.1	-0.1
Conditioned locomotion	0.1	0.1	0.3	0.3	-0.5	0.5	0.3	-0.1
Cocaine response after cond. corrected	2.4	2.7	5.0	1.5	-2.2	2.2	1.1	-0.6
Cocaine response after cond. not corrected	2.8	3.1	4.9	1.7	-2.2	2.2	1.3	-1.0
Cocaine response before conditioning	0.3	0.3	0.9	0.4	0.4	-0.4	0.4	-0.9
Saline control response	0.1	0.2	0.2	-0.5	-0.4	0.4	-0.4	0.4
Bone: connectivity density	0.2	0.3	0.4	-0.5	0.6	-0.6	0.3	-0.4
Bone: cortical apparent density	1.0	1.3	2.8	0.4	-1.7	1.7	0.1	0.9
Bone: cortical area	11.0	16.6	19.1	-4.4	4.2	-4.2	-4.0	3.6
Bone: cortical porosity	0.1	0.1	0.3	-0.1	0.5	-0.5	0.1	-0.3
Bone: cortical porosity	0.2	0.3	0.6	-0.1	0.7	-0.7	0.2	-0.3
Bone: cortical thickness	5.4	8.9	9.8	-3.1	2.8	-2.8	-3.1	3.0
Bone: cortical thickness	1.7	2.0	3.5	-1.4	1.1	-1.1	-1.5	1.9
Bone: cortical tissue density	1.2	1.6	3.5	0.7	-1.8	1.9	0.3	0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.2	-0.3	0.3	-0.3	0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	-0.2	0.2	-0.1	-0.1
Condit. Reinf. active responses	0.9	1.1	1.7	-1.3	0.9	-0.9	-1.3	0.9
Condit. Reinf. inactive responses	2.2	2.6	4.2	-2.1	1.5	-1.5	-1.7	1.1
Incentive salience index mean	0.1	0.2	0.4	0.2	-0.6	0.6	-0.1	0.0
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.2	-0.4	0.4	-0.3	0.1
Condit. Reinf. active minus inactive responses	2.8	3.5	5.7	-1.5	2.4	-2.4	-1.9	0.5
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.5	-0.6	1.2	-1.2	-0.6	-0.1
Condit. Reinf. active responses	4.8	6.7	10.0	-2.2	3.1	-3.2	-2.7	1.1
Condit. Reinf. inactive responses	2.3	2.9	3.9	-1.5	1.9	-1.9	-2.0	0.9
Condit. Reinf. lever presses	0.7	0.9	1.8	-0.7	1.3	-1.3	-0.8	0.1
Condit. Reinf. lever reinforcers received	3.4	4.7	7.1	-1.8	2.7	-2.7	-2.3	0.8
Conditioned reinforcement - actives	0.5	0.5	1.2	0.2	-1.1	1.1	0.0	0.3
Conditioned reinforcement - inactives	0.4	0.5	1.0	-0.4	0.6	-0.5	-1.0	0.8
Conditioned locomotion	0.6	0.7	1.6	0.3	-1.2	1.2	0.5	0.1
Patch foraging indifference point 0 sec	4.5	7.2	9.8	-3.1	2.8	-2.8	-2.5	2.1
Patch foraging indifference point AUC	0.7	0.8	1.7	-1.3	1.1	-1.1	-0.3	-0.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	-0.3	0.4	-0.4	-0.4	0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.0	0.4	-0.4	0.2	-0.6
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	0.8	-0.4	0.4	0.7	-0.3
Delay disc. indifference point, 24s delay	0.7	0.7	1.6	-0.3	1.3	-1.3	-0.3	-0.4
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	1.0	-0.3	0.3	0.6	-0.7
Delay disc. indifference point, 8s delay	4.8	5.0	6.0	-2.5	2.3	-2.3	-2.4	1.7
Indifference point function ln k	0.1	0.1	0.2	0.0	-0.3	0.3	-0.2	0.5
Indifference point function log k	0.1	0.1	0.2	0.0	-0.3	0.3	-0.2	0.5
Patch foraging total patch changes 0 sec	4.4	7.1	9.3	-3.1	2.9	-2.9	-2.4	1.9
Patch foraging total patch changes 12 sec	1.4	1.8	3.0	-1.6	1.7	-1.7	-0.8	0.3
Patch foraging total patch changes 18 sec	4.1	5.3	7.5	-2.7	2.7	-2.7	-1.7	1.0
Patch foraging total patch changes 24 sec	2.9	3.5	5.6	-2.2	2.4	-2.4	-1.2	0.5
Patch foraging total patch changes 6 sec	6.1	9.0	11.4	-3.4	3.3	-3.3	-2.7	2.0
Patch foraging time to switch 0 sec	0.7	1.1	2.0	1.4	-1.1	1.1	0.8	-0.7
Patch foraging water rate 0 sec	1.0	1.6	2.7	-1.6	1.2	-1.2	-1.2	1.0
Patch foraging water rate 12 sec	2.0	3.1	4.6	-2.1	2.1	-2.1	-1.2	0.7
Patch foraging water rate 18 sec	0.6	0.8	1.5	-1.0	0.6	-0.6	-0.8	1.2
Patch foraging water rate 24 sec	1.0	1.4	2.2	-1.4	0.8	-0.8	-1.1	1.5
Patch foraging water rate 6 sec	0.4	0.6	1.3	-1.2	0.4	-0.4	-0.7	1.1
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.0	1.0	-1.0	1.0	0.8	-0.4
Distance traveled before self-admin	0.8	0.8	1.4	1.0	-1.2	1.2	0.5	0.2
Distance traveled after self-admin	0.6	0.6	1.0	0.5	-1.0	1.0	0.4	0.9
Extensor digitorum longus weight	0.5	1.9	3.1	-1.5	1.8	-1.8	-1.0	0.5
Bone: elastic displacement	0.2	0.2	0.6	0.8	-0.1	0.1	0.5	-0.5
Bone: elastic work	0.7	0.8	2.2	-0.9	0.5	-0.5	-0.9	1.5
Bone: endosteal estimation	1.6	3.4	5.0	-2.2	2.0	-2.0	-1.4	1.5
Bone: endosteal perimeter	5.4	11.3	13.7	-3.7	3.3	-3.3	-3.3	3.2
Epididymis fat weight	13.4	31.2	34.3	-5.7	5.9	-5.8	-5.4	5.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	0.5	-0.7	0.7	0.2	0.0
Delta time in open arm before/after self-admin	0.4	0.4	0.7	-0.6	0.8	-0.8	-0.4	-0.1
Diff in mean of infusions in LGA sessions	3.2	3.6	6.1	2.1	-1.1	1.1	2.2	-2.5
Delay discount exponential model param	0.5	0.6	1.1	0.4	-1.0	1.0	0.7	-0.2
Extinction: sum of active levers before priming	0.9	0.9	1.8	1.2	-0.5	0.4	0.9	-1.3
Active lever presses in extinction session 6	0.1	0.1	0.3	0.6	0.2	-0.2	-0.4	0.1
Bone: final force	3.8	6.1	9.1	-3.0	2.2	-2.2	-2.4	2.5
Bone: final moment	3.7	6.0	8.5	-2.9	2.3	-2.2	-2.3	2.5
Food consumed during 24 hour testing period	0.3	0.4	1.4	1.2	-0.4	0.4	0.2	-0.1
Glucose	5.1	7.6	8.1	-2.8	2.7	-2.7	-2.7	2.8
Heart weight	2.9	4.2	4.7	-2.1	1.9	-1.9	-2.2	2.2
Delay discount hyperbolic model param	0.3	0.3	0.6	0.2	-0.7	0.7	0.4	-0.1
Intermittent access intake day 1-15 change	2.7	2.6	3.8	-1.2	1.6	-1.6	-2.0	1.6
Intermittent access intake escalation	3.1	3.0	5.4	-1.3	1.3	-1.2	-2.2	2.3
Intermittent access intake escalation 2	1.2	1.2	3.0	-0.6	0.5	-0.5	-1.5	1.7
Intermitt. access day 1 inactive lever presses	1.9	2.0	3.2	-1.3	1.8	-1.8	-1.1	0.7
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	0.0	0.3	-0.3	-0.4	0.4
Intermitt. access escalation Index	0.2	0.2	0.5	0.7	-0.4	0.4	0.1	0.1
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.1	0.0
Intermittent access day 15 total infusions	0.7	0.8	1.5	-0.5	0.5	-0.5	-1.2	1.2
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.7	-0.4	0.2	-0.2	-0.8	0.8
Intermittent access total infusions	0.7	0.8	1.5	-0.9	0.4	-0.4	-1.2	1.1
Intermittent access day 1 locomotion	0.3	0.3	0.7	0.1	-0.8	0.8	0.4	0.1
Intermittent access day 15 total locomotion	3.0	3.2	4.4	-1.7	1.7	-1.7	-2.1	1.7
Intermittent access total locomotion	0.5	0.5	1.5	-0.8	-0.2	0.2	-0.8	1.2
Intermittent access standard deviation	0.7	0.7	1.3	-0.5	1.1	-1.1	-0.9	0.3
Left kidney weight	1.7	4.8	15.2	-2.0	0.4	-0.4	-2.1	3.9
Right kidney weight	4.4	12.4	24.5	-4.1	2.1	-2.0	-3.6	4.9
Cocaine induced anxiety	6.9	7.9	9.1	3.0	-3.0	3.0	2.9	-2.0
Post-drug Anxiety	1.7	1.9	2.4	1.4	-1.5	1.6	1.4	-0.8
Baseline Anxiety	7.3	7.7	9.4	-2.9	3.1	-3.0	-2.7	2.1
Tail length	0.1	0.4	0.8	-0.4	0.9	-0.9	-0.2	0.3
Length with tail	1.9	7.1	8.0	-2.7	2.6	-2.5	-2.6	2.8
Length without tail	5.3	11.7	13.6	-3.6	3.1	-3.0	-3.7	3.6
Times rat made contact with spout	0.2	0.2	0.7	-0.1	0.2	-0.1	-0.5	0.8
Lifetime Intake	0.8	0.9	1.7	-1.0	0.4	-0.4	-1.3	1.2
Liver weight, left	3.8	6.1	7.5	-2.3	2.7	-2.7	-2.5	2.1
Liver weight, right	6.6	11.0	11.1	-3.3	3.3	-3.3	-3.3	3.3
Locomotor activity	1.4	2.3	3.5	-1.7	1.1	-1.1	-1.7	1.9
Locomotor testing distance	1.9	3.1	6.1	-1.9	0.8	-0.8	-2.1	2.5
Locomotor testing rearing	0.8	1.3	2.6	-0.9	0.6	-0.5	-1.5	1.6
Locomotion in novel chamber	0.5	0.6	1.1	0.6	-1.0	1.0	0.2	0.5
Locomotion in novel chamber post-restriction	0.9	1.1	2.6	0.4	-1.6	1.6	0.5	-0.1
Fecal boli incidents, locomotor time 1	2.1	2.3	3.0	-1.7	1.5	-1.5	-1.7	0.8
Change in fecal boli incidents, locomotor task	3.1	2.9	5.3	2.3	-1.4	1.3	1.9	-1.4
Time >=10cm from walls, locomotor time 1	2.1	2.1	2.9	1.6	-1.3	1.2	1.7	-1.4
Bouts of movement, locomotor time 1	1.0	1.1	1.7	-1.2	1.3	-1.3	-0.7	0.2
Total resting periods, locomotor time 1	0.7	0.8	1.3	-1.2	1.1	-1.1	-0.5	0.3
Rest time, locomotor task time 1	0.4	0.4	1.2	-1.1	-0.0	0.1	-0.4	0.8
Distance moved, locomotor task time 1	0.2	0.2	0.7	0.8	0.2	-0.2	-0.1	-0.3
Vertical activity count, locomotor time 1	1.0	1.0	2.3	1.5	-0.9	0.9	0.8	-0.6
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.1	0.5	-0.5	0.3	-0.4
Bouts of movement, locomotor time 2	3.0	3.2	5.5	1.6	-1.6	1.6	2.3	-1.7
Total resting periods, locomotor time 2	2.0	2.1	3.7	1.3	-1.3	1.3	1.9	-1.3
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.5	0.0	-0.0	-0.4	0.6
Distance moved, locomotor task time 2	0.3	0.3	0.6	-0.5	0.8	-0.8	-0.4	-0.1
Vertical activity count, locomotor time 2	0.3	0.3	0.5	-0.6	0.7	-0.7	-0.6	0.2
Light reinforcement 1	1.8	3.3	4.3	1.7	-1.8	1.7	2.1	-1.7
Light reinforcement 2	3.0	4.1	5.1	1.9	-2.1	2.1	2.3	-1.6
Bone: marrow area	1.6	3.6	5.2	-2.3	2.0	-2.0	-1.4	1.5
Bone: maximum diameter	9.2	16.9	20.0	-4.3	4.5	-4.4	-3.9	3.4
Bone: maximum force	3.4	5.8	8.3	-2.9	2.1	-2.1	-2.3	2.5
Bone: maximum moment	3.3	5.6	7.5	-2.7	2.2	-2.2	-2.2	2.4
Mean time between licks in bursts	0.1	0.1	0.3	0.5	0.3	-0.4	-0.0	-0.4
Mean num. licks in bursts	0.4	0.4	1.1	-0.2	-0.7	0.7	-0.3	1.1
Cd content in liver	2.5	2.7	3.6	1.7	-1.4	1.4	1.8	-1.9
Co content in liver	0.1	0.1	0.3	-0.4	-0.5	0.5	0.1	0.1
Cu content in liver	0.2	0.2	0.5	-0.7	0.1	-0.1	-0.3	0.6
Fe content in liver	0.0	0.1	0.1	-0.3	0.2	-0.2	-0.2	-0.1
K content in liver	0.4	0.4	0.8	0.4	-0.5	0.5	0.9	-0.9
Mg content in liver	0.2	0.2	0.6	0.3	0.1	-0.1	0.5	-0.8
Mn content in liver	1.2	1.4	1.5	1.2	-1.2	1.2	1.2	-1.0
Na content in liver	0.3	0.3	1.3	0.4	-0.1	0.1	0.6	-1.1
Rb content in liver	1.7	2.1	3.9	1.5	-0.9	0.9	1.6	-2.0
Se content in liver	0.1	0.1	0.3	-0.2	0.0	-0.1	0.3	-0.5
Sr content in liver	3.1	2.9	4.3	1.4	-2.1	2.1	1.6	-1.1
Zn content in liver	2.4	2.6	3.5	1.4	-1.9	1.9	1.6	-1.2
Bone: minimum diameter	3.9	7.2	9.0	-3.0	3.0	-3.0	-2.2	2.1
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	0.3
Time in novel zone, hab. session 1	0.5	0.4	1.0	-0.4	1.0	-1.0	-0.3	0.1
Total zone transitions, hab. session 1	1.1	1.5	3.0	-1.4	0.6	-0.6	-1.4	1.7
Total locomotion distance, hab. session 1	0.1	0.2	0.5	0.7	-0.4	0.4	0.2	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	1.0	1.0	-0.7	0.7	0.4	-0.3
Time in familiar zone, hab. session 2	1.6	1.7	3.3	-0.7	1.8	-1.8	-1.2	0.3
Time in novel zone, hab. session 2	0.5	0.5	1.2	-0.1	-1.1	1.1	0.4	0.4
Total zone transitions, hab. session 2	1.4	1.7	3.0	-1.4	0.9	-0.9	-1.5	1.7
Total locomotion distance, hab. session 2	0.1	0.2	0.7	0.1	0.1	-0.1	-0.5	0.8
Locomotion velocity, hab. session 2	0.1	0.1	0.4	0.2	-0.1	0.1	-0.3	0.6
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.2	0.5	-0.5	0.0	-0.3
Novelty place preference	0.2	0.2	0.4	-0.3	0.6	-0.6	-0.1	-0.2
Time in novel zone, NPP test	0.5	0.6	1.2	-0.6	1.1	-1.1	-0.4	-0.0
Total zone transitions, NPP test	0.3	0.4	1.0	-0.5	0.3	-0.3	-0.7	1.0
Total locomotion distance, NPP test	0.0	0.1	0.2	0.4	-0.1	0.1	-0.0	0.3
Locomotion velocity, NPP test	0.3	0.4	0.7	0.9	-0.7	0.7	0.4	0.1
Intraocular pressure	5.4	7.5	8.9	-2.7	3.0	-3.0	-2.9	1.9
Delta distance traveled before/after self-admin	0.2	0.2	0.8	-0.3	0.2	-0.1	-0.1	0.9
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.1	0.5
Parametrial fat weight	9.2	17.9	24.0	-4.3	4.9	-4.9	-3.8	3.0
Pavlov. Cond. lever latency	0.2	0.2	0.4	-0.0	0.6	-0.6	-0.3	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.3	0.0	0.0	-0.2	0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1	0.3
Pavlov. Cond. index score	0.1	0.1	0.4	-0.1	0.1	-0.1	-0.3	0.6
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.2	0.0	-0.0	-0.2	0.6
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	-0.1	0.1	0.0	0.2
Pavlov. Cond. magazine entry number	0.6	0.8	1.6	0.6	-0.7	0.6	1.1	-1.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	-0.8	0.3	-0.3	-0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.1	0.2	-0.2	-0.3	0.5
Pavlov. Cond. response bias	0.1	0.2	0.6	-0.1	0.0	-0.0	-0.4	0.8
Pavlov. Cond. lever latency	0.5	0.7	1.3	0.7	-1.1	1.1	0.5	0.2
Pavlov. Cond. magazine entry latency	0.6	0.7	1.3	-0.4	1.1	-1.1	-0.7	0.5
Pavlov. Cond. change in total contacts	1.2	1.6	2.6	-1.0	1.6	-1.6	-1.3	0.4
Pavlov. Cond. index score	1.2	1.6	2.4	-1.1	1.6	-1.6	-1.2	0.7
Pavlov. Cond. latency score	1.1	1.4	2.2	-1.0	1.5	-1.5	-1.1	0.6
Pavlov. Cond. lever contacts	0.4	0.6	1.0	-0.7	1.0	-1.0	-0.6	0.2
Pavlov. Cond. magazine entry number	0.5	0.6	1.2	0.3	-1.1	1.1	0.7	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.0	0.4	-0.4	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.1	-1.1	1.4	-1.4	-1.3	0.8
Pavlov. Cond. response bias	0.8	1.1	1.8	-0.8	1.3	-1.3	-0.9	0.5
Time in closed arm before self-admin	0.0	0.0	0.1	0.3	-0.0	0.0	0.2	0.3
Time in closed arm after self-admin	0.8	0.9	1.1	1.1	-1.1	1.1	0.9	-0.4
Time in open arm before self-admin	1.7	1.8	2.5	1.5	-1.1	1.1	1.4	-1.6
Time in open arm after self-admin	0.2	0.2	1.0	0.2	0.0	-0.1	0.2	-1.0
Bone: periosteal estimation	6.2	12.7	15.9	-4.0	3.7	-3.7	-3.2	3.2
Bone: periosteal perimeter	12.2	20.3	24.3	-4.9	4.5	-4.5	-4.4	4.2
Bone: post-yield work	0.1	0.1	0.2	-0.1	0.2	-0.2	0.3	-0.4
Progressive ratio test 1 active lever presses	0.7	0.7	1.6	-0.6	0.1	-0.1	-1.3	1.2
Progressive ratio test 1 breakpoint	0.3	0.3	0.7	-0.5	-0.0	0.0	-0.9	0.7
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.6	-0.1	0.1	-0.5	0.4
Progressive ratio test 2 active lever presses	2.0	2.2	3.6	-1.4	0.9	-0.9	-1.9	1.9
Progressive ratio test 2 breakpoint	1.8	2.0	3.3	-1.4	0.9	-0.9	-1.8	1.7
Progressive ratio test 2 inactive lever presses	0.9	1.0	1.4	-0.7	1.1	-1.1	-1.2	0.9
Incentive Sensitization - Responses	1.7	1.7	2.2	-1.3	1.2	-1.2	-1.5	1.3
Incentive Sensitization - Breakpoint	1.9	1.9	2.4	-1.4	1.3	-1.3	-1.6	1.3
Sum of active levers in priming session hrs 5-6	2.2	2.1	2.9	1.6	-1.1	1.1	1.7	-1.7
Progressive ratio	0.6	0.7	1.1	1.0	-0.7	0.7	0.5	-1.0
Food seeking constrained by brief footshock	0.9	1.1	2.1	1.4	-0.3	0.2	1.1	-1.4
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.1	0.2	-0.2	0.4	0.1
Retroperitoneal fat weight	12.2	40.2	44.4	-6.7	6.5	-6.5	-6.0	6.0
Reaction time number correct	0.9	1.2	1.7	-1.1	1.3	-1.3	-1.0	0.7
Reaction time mean minus median	0.6	0.8	1.7	-0.7	0.6	-0.6	-1.3	1.1
Reaction time mean minus median AUC	0.5	0.6	1.8	-0.5	0.1	-0.1	-1.1	1.3
Reaction time num false alarms	0.0	0.1	0.1	-0.3	-0.1	0.1	0.3	-0.2
Reaction time num false alarms AUC	0.0	0.1	0.1	-0.4	-0.2	0.2	0.2	0.1
Reaction time trials correct on left	0.9	1.2	1.7	-1.1	1.3	-1.3	-1.0	0.7
Reaction time trials on left	0.9	1.3	1.8	-1.2	1.4	-1.4	-1.1	0.8
Reaction time mean	0.5	0.7	1.4	-0.8	0.4	-0.4	-1.2	1.0
Reaction time mean AUC	0.2	0.2	0.6	-0.4	0.1	-0.1	-0.7	0.6
Median of all reaction times	0.4	0.5	1.0	-0.8	0.2	-0.2	-0.9	1.0
Reaction time omissions	0.3	0.4	0.6	-0.7	0.7	-0.7	-0.6	0.5
Reaction time false alarm rate	0.3	0.4	0.5	0.3	-0.7	0.7	0.7	-0.4
Reaction time premature initiation rate	0.4	0.5	1.7	-0.7	-0.2	0.2	-0.5	1.3
Reaction time premature initiations	1.0	1.5	3.4	-1.3	0.6	-0.5	-1.2	1.8
Std. dev. reaction times	2.0	2.9	4.7	-1.6	1.3	-1.3	-2.2	1.9
Reaction time trials completed	0.9	1.3	1.8	-1.2	1.4	-1.4	-1.1	0.8
Reaction time trials AUC	1.0	1.5	2.0	-1.2	1.4	-1.4	-1.1	0.8
Run reversals in cocaine runway, females	1.0	0.9	1.6	-1.3	0.6	-0.5	-0.9	1.3
Run reversals in cocaine runway, males	2.9	2.8	4.0	1.9	-1.3	1.3	2.0	-1.8
Latency to leave start box in cocaine runway	1.0	1.1	2.0	1.4	-0.8	0.8	1.1	-1.0
Latency to leave start box in cocaine runway, F	1.2	1.4	2.3	1.5	-1.0	0.9	1.3	-1.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.2	0.2	-0.2	-0.4	0.3
Std. dev. time between licks in bursts	0.2	0.3	0.8	0.2	-0.2	0.2	0.7	-0.9
Total sessions with >9 infusions	5.1	5.7	9.4	-2.6	1.3	-1.2	-3.0	3.1
Short access day 1 total inactive lever presses	0.2	0.2	0.6	0.8	0.2	-0.1	-0.5	0.5
Short access day 10 total inactive lever presses	0.9	1.0	1.2	-1.0	1.1	-1.1	-0.9	0.7
Short access day 1 total infusions	0.4	0.5	1.3	-0.2	-0.2	0.2	-1.0	1.1
Short access day 10 total infusions	0.2	0.2	0.3	-0.2	-0.4	0.5	-0.6	0.5
Short access total infusions	0.4	0.4	0.9	-0.5	-0.1	0.2	-0.9	0.9
Short access day 1 locomotion	0.4	0.4	1.1	-0.4	0.2	-0.2	-1.1	0.9
Short access day 10 total locomotion	0.4	0.5	1.3	-0.7	0.2	-0.2	-0.7	1.2
Short access total locomotion	0.7	0.7	2.0	-0.9	-0.4	0.4	-0.7	1.4
One hour access (0.3 mA shock)	1.2	1.4	2.4	-0.6	1.3	-1.3	-1.5	0.8
Compulsive drug intake	0.3	0.3	0.8	0.7	0.0	-0.0	0.6	-0.9
One hour access (shock baseline)	1.7	1.9	3.2	-1.4	1.0	-1.0	-1.8	1.7
Social response proportion	1.8	2.0	5.5	-1.4	0.5	-0.4	-1.5	2.4
Social responses	5.3	6.8	7.8	-2.7	2.5	-2.5	-2.8	2.5
Social time	1.3	1.8	3.6	-1.3	0.8	-0.8	-1.5	1.9
Soleus weight	3.0	8.9	13.5	-3.3	2.4	-2.4	-2.9	3.7
Bone: stiffness	2.4	3.8	5.5	-2.4	1.5	-1.5	-2.1	2.1
Tibialis anterior weight	0.2	0.7	1.6	-1.3	0.9	-0.9	-0.1	-0.3
Time to tail flick, vehicle, before self-admin	3.1	3.2	4.0	-1.6	2.0	-2.0	-2.0	1.3
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.7	-0.7	0.3	-0.3	-0.9	0.8
Time to tail flick, test, before self-admin	1.0	0.9	3.1	-0.8	-0.5	0.5	-0.7	1.8
Time to tail flick, test, after self-admin	2.7	2.8	3.6	-1.9	1.8	-1.8	-1.4	1.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.0	-0.3	0.3	0.2	-0.1
Delta time to tail flick, test, before/after SA	3.3	2.9	4.5	-1.8	2.1	-2.1	-1.4	0.7
Tibia length	1.4	4.1	7.5	-2.1	1.5	-1.4	-2.0	2.7
Ambulatory time before self-admin	0.2	0.2	0.6	0.3	-0.4	0.5	-0.3	0.8
Ambulatory time after self-admin	0.5	0.5	0.9	0.6	-0.8	0.8	0.2	1.0
Bone: tissue strength	0.3	0.3	0.5	0.7	-0.2	0.2	0.6	-0.7
Total heroin consumption	0.7	0.8	1.5	-0.8	1.2	-1.2	-0.6	0.2
Bone: trabecular number	0.8	1.2	2.4	-1.2	1.5	-1.5	-0.3	-0.1
Bone: trabecular spacing	0.1	0.1	0.5	0.7	-0.2	0.2	0.0	-0.4
Bone: trabecular thickness	5.7	6.8	8.8	-2.7	3.0	-3.0	-2.3	1.9
Bone: trabecular tissue density	0.6	0.8	2.1	-0.9	0.2	-0.2	-1.1	1.4
Water consumed over 24 hours	0.2	0.2	0.8	-0.0	-0.2	0.2	-0.4	0.9
Number of responses in last shaping day	0.1	0.1	0.2	-0.0	-0.3	0.3	-0.3	0.5