Hub : Genes

LOC102547573

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression LOC102547573 0.37 0.18 3.4e-06 0.3 0.24 0.29 0.26 7.0e-08 1.8e-06 1.0e-07 6.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density2.03.63.6-1.9
Area under the delay curve0.20.30.3-0.6
BMI with tail10.436.336.3-6.0
BMI without tail4.021.321.3-4.6
Body weight9.642.142.1-6.5
Weight adjusted by age4.312.712.7-3.6
Bone surface1.22.42.4-1.6
Bone volume3.16.26.2-2.5
Breakpoint value in progressive ratio session0.00.10.1-0.3
Number of licking bursts0.00.00.0-0.1
Context. condit. distance diff. score2.73.33.31.8
Locomotion velocity, session 10.00.00.00.0
Locomotion distance, session 10.00.10.1-0.2
Locomotion velocity, session 20.00.00.00.2
Locomotion distance, session 21.31.91.9-1.4
Locomotion velocity, session 30.00.00.00.1
Locomotion distance, session 30.00.00.00.2
Stereotopy head waving bouts, day 30.50.60.6-0.8
Stereotopy head waving duration, day 30.10.10.1-0.4
Locomotion velocity, session 70.50.50.5-0.7
Locomotion distance, session 70.00.00.0-0.0
Stereotopy head waving bouts, day 70.10.10.1-0.3
Stereotopy head waving duration, day 71.11.31.3-1.2
Locomotion velocity, session 82.53.13.11.7
Locomotion distance, session 81.92.72.71.7
Degree of sensitization distance0.20.30.30.5
Degree of sensitization stereotypy0.10.10.1-0.2
Conditioned locomotion0.10.10.10.2
Cocaine response after cond. corrected0.81.31.31.1
Cocaine response after cond. not corrected1.42.02.01.4
Cocaine response before conditioning0.20.20.20.5
Saline control response0.00.00.00.1
Bone: connectivity density0.20.40.4-0.6
Bone: cortical apparent density0.40.60.60.8
Bone: cortical area12.119.719.7-4.4
Bone: cortical porosity0.10.10.10.3
Bone: cortical porosity0.00.00.0-0.1
Bone: cortical thickness6.510.810.8-3.3
Bone: cortical thickness2.53.13.1-1.8
Bone: cortical tissue density0.71.01.01.0
Condit. Reinf. active minus inactive responses0.20.20.20.4
Condit. Reinf. active-inactive response ratio0.40.50.50.7
Condit. Reinf. active responses0.71.01.0-1.0
Condit. Reinf. inactive responses3.34.34.3-2.1
Incentive salience index mean0.10.20.20.4
Condit. Reinf. lever presses0.00.00.00.0
Condit. Reinf. active minus inactive responses2.03.13.1-1.7
Condit. Reinf. active-inactive response ratio0.30.50.5-0.7
Condit. Reinf. active responses3.85.55.5-2.3
Condit. Reinf. inactive responses1.42.12.1-1.5
Condit. Reinf. lever presses0.50.80.8-0.9
Condit. Reinf. lever reinforcers received2.53.53.5-1.9
Conditioned reinforcement - actives0.00.20.2-0.4
Conditioned reinforcement - inactives0.20.50.5-0.7
Conditioned locomotion0.00.10.1-0.3
Patch foraging indifference point 0 sec2.98.08.0-2.8
Patch foraging indifference point AUC0.20.60.6-0.8
Delay disc. indifference point, 0s delay0.20.30.3-0.5
Delay disc. indifference point, 16s delay0.00.00.0-0.2
Delay disc. indifference point, 2s delay0.70.80.80.9
Delay disc. indifference point, 24s delay0.00.00.0-0.2
Delay disc. indifference point, 4s delay0.30.40.40.6
Delay disc. indifference point, 8s delay3.66.16.1-2.5
Indifference point function ln k0.00.10.10.3
Indifference point function log k0.00.10.10.3
Patch foraging total patch changes 0 sec2.77.97.9-2.8
Patch foraging total patch changes 12 sec2.02.72.7-1.6
Patch foraging total patch changes 18 sec2.86.66.6-2.6
Patch foraging total patch changes 24 sec1.34.54.5-2.1
Patch foraging total patch changes 6 sec6.210.410.4-3.2
Patch foraging time to switch 0 sec0.41.71.71.3
Patch foraging water rate 0 sec0.62.42.4-1.5
Patch foraging water rate 12 sec1.04.04.0-2.0
Patch foraging water rate 18 sec0.51.21.2-1.1
Patch foraging water rate 24 sec1.21.71.7-1.3
Patch foraging water rate 6 sec1.42.12.1-1.4
Seeking ratio, delayed vs. immediate footshock0.91.31.31.1
Distance traveled before self-admin0.51.01.01.0
Distance traveled after self-admin0.10.20.20.5
Extensor digitorum longus weight0.41.71.7-1.3
Bone: elastic displacement0.40.50.50.7
Bone: elastic work0.60.70.7-0.9
Bone: endosteal estimation1.53.73.7-1.9
Bone: endosteal perimeter5.413.213.2-3.6
Epididymis fat weight8.442.342.3-6.5
Delta time in closed arm before/after self-admin0.00.00.00.1
Delta time in open arm before/after self-admin0.80.90.9-0.9
Diff in mean of infusions in LGA sessions0.91.61.61.3
Delay discount exponential model param0.20.30.30.5
Extinction: sum of active levers before priming0.40.60.60.8
Active lever presses in extinction session 60.00.00.00.0
Bone: final force5.48.88.8-3.0
Bone: final moment5.08.18.1-2.8
Food consumed during 24 hour testing period0.40.90.90.9
Glucose2.43.93.9-2.0
Heart weight3.25.15.1-2.3
Delay discount hyperbolic model param0.10.10.10.3
Intermittent access intake day 1-15 change0.21.41.4-1.2
Intermittent access intake escalation0.21.01.0-1.0
Intermittent access intake escalation 20.40.70.7-0.8
Intermitt. access day 1 inactive lever presses0.22.02.0-1.4
Intermitt. access day 15 inactive lever presses0.00.00.0-0.2
Intermitt. access escalation Index0.10.20.20.5
Intermittent access day 1 total infusions0.20.60.6-0.8
Intermittent access day 15 total infusions0.20.40.4-0.7
Intermittent access terminal intake (last 3 days)0.10.20.2-0.4
Intermittent access total infusions1.51.81.8-1.3
Intermittent access day 1 locomotion0.20.30.3-0.6
Intermittent access day 15 total locomotion0.93.43.4-1.8
Intermittent access total locomotion1.21.51.5-1.2
Intermittent access standard deviation0.21.01.0-1.0
Left kidney weight0.65.05.0-2.2
Right kidney weight1.712.212.2-3.5
Cocaine induced anxiety3.39.19.13.0
Post-drug Anxiety1.61.81.81.3
Baseline Anxiety2.74.54.5-2.1
Tail length0.00.20.2-0.4
Length with tail0.93.83.8-1.9
Length without tail1.910.010.0-3.2
Times rat made contact with spout0.00.00.0-0.1
Lifetime Intake1.72.12.1-1.4
Liver weight, left3.86.66.6-2.6
Liver weight, right4.98.68.6-2.9
Locomotor activity1.32.02.0-1.4
Locomotor testing distance1.12.72.7-1.6
Locomotor testing rearing0.20.70.7-0.8
Locomotion in novel chamber0.40.50.50.7
Locomotion in novel chamber post-restriction0.20.50.50.7
Fecal boli incidents, locomotor time 11.02.72.7-1.6
Change in fecal boli incidents, locomotor task6.36.76.72.6
Time >=10cm from walls, locomotor time 11.92.42.41.5
Bouts of movement, locomotor time 11.11.41.4-1.2
Total resting periods, locomotor time 11.01.21.2-1.1
Rest time, locomotor task time 10.71.11.1-1.1
Distance moved, locomotor task time 10.20.60.60.8
Vertical activity count, locomotor time 10.32.02.01.4
Time >=10cm from walls, locomotor time 20.00.00.00.0
Bouts of movement, locomotor time 20.72.42.41.5
Total resting periods, locomotor time 20.31.41.41.2
Rest time, locomotor task time 20.10.20.2-0.5
Distance moved, locomotor task time 20.30.40.4-0.6
Vertical activity count, locomotor time 20.20.40.4-0.7
Light reinforcement 10.94.34.32.1
Light reinforcement 21.63.63.61.9
Bone: marrow area1.53.83.8-1.9
Bone: maximum diameter9.318.718.7-4.3
Bone: maximum force3.56.86.8-2.6
Bone: maximum moment3.15.85.8-2.4
Mean time between licks in bursts0.00.20.20.4
Mean num. licks in bursts0.00.10.1-0.2
Cd content in liver0.60.70.70.8
Co content in liver0.00.00.0-0.0
Cu content in liver0.00.10.10.2
Fe content in liver0.70.80.8-0.9
K content in liver0.20.20.20.5
Mg content in liver0.50.50.50.7
Mn content in liver0.91.01.01.0
Na content in liver0.70.80.80.9
Rb content in liver2.42.82.81.7
Se content in liver0.70.80.80.9
Sr content in liver1.71.51.51.2
Zn content in liver0.70.90.90.9
Bone: minimum diameter4.58.68.6-2.9
Time in familiar zone, hab. session 10.00.00.0-0.0
Time in novel zone, hab. session 10.20.30.3-0.5
Total zone transitions, hab. session 11.31.91.9-1.4
Total locomotion distance, hab. session 10.40.50.50.7
Locomotion velocity, hab. session 10.71.01.01.0
Time in familiar zone, hab. session 20.50.50.5-0.7
Time in novel zone, hab. session 20.00.00.0-0.0
Total zone transitions, hab. session 21.62.12.1-1.4
Total locomotion distance, hab. session 20.00.00.00.0
Locomotion velocity, hab. session 20.00.00.00.1
Novel to familiar place preference ratio0.00.00.0-0.2
Novelty place preference0.10.10.1-0.3
Time in novel zone, NPP test0.30.40.4-0.6
Total zone transitions, NPP test0.30.50.5-0.7
Total locomotion distance, NPP test0.10.10.10.3
Locomotion velocity, NPP test0.40.60.60.7
Intraocular pressure4.47.27.2-2.7
Delta distance traveled before/after self-admin0.00.00.0-0.1
Delta ambulatory time before/after self-admin0.00.00.0-0.2
Parametrial fat weight13.732.232.2-5.7
Pavlov. Cond. lever latency0.00.00.00.0
Pavlov. Cond. magazine entry latency0.00.00.00.2
Pavlov. Cond. change in total contacts0.00.00.0-0.2
Pavlov. Cond. index score0.10.10.1-0.3
Pavlov. Cond. latency score0.10.10.1-0.3
Pavlov. Cond. lever contacts0.00.00.0-0.2
Pavlov. Cond. magazine entry number0.40.50.50.7
Pavlov. Cond. intertrial magazine entries0.20.30.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.2
Pavlov. Cond. response bias0.00.00.0-0.1
Pavlov. Cond. lever latency0.20.30.30.5
Pavlov. Cond. magazine entry latency0.10.10.1-0.3
Pavlov. Cond. change in total contacts0.30.70.7-0.8
Pavlov. Cond. index score0.40.70.7-0.8
Pavlov. Cond. latency score0.40.60.6-0.8
Pavlov. Cond. lever contacts0.20.30.3-0.6
Pavlov. Cond. magazine entry number0.10.10.10.3
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.50.70.7-0.9
Pavlov. Cond. response bias0.30.50.5-0.7
Time in closed arm before self-admin0.30.50.50.7
Time in closed arm after self-admin1.31.51.51.2
Time in open arm before self-admin1.21.51.51.2
Time in open arm after self-admin0.60.60.6-0.8
Bone: periosteal estimation6.315.015.0-3.9
Bone: periosteal perimeter13.025.725.7-5.1
Bone: post-yield work0.10.10.10.3
Progressive ratio test 1 active lever presses0.71.31.3-1.1
Progressive ratio test 1 breakpoint0.81.41.4-1.2
Progressive ratio test 1 inactive lever presses0.00.10.1-0.3
Progressive ratio test 2 active lever presses1.42.02.0-1.4
Progressive ratio test 2 breakpoint1.62.12.1-1.4
Progressive ratio test 2 inactive lever presses0.72.12.1-1.5
Incentive Sensitization - Responses0.41.11.1-1.1
Incentive Sensitization - Breakpoint0.40.90.9-1.0
Sum of active levers in priming session hrs 5-60.30.30.30.5
Progressive ratio0.30.80.80.9
Food seeking constrained by brief footshock1.82.32.31.5
Seeking ratio, punishment vs. effort0.00.00.00.1
Retroperitoneal fat weight11.953.253.2-7.3
Reaction time number correct0.41.31.3-1.2
Reaction time mean minus median0.10.80.8-0.9
Reaction time mean minus median AUC0.10.60.6-0.7
Reaction time num false alarms0.10.10.1-0.3
Reaction time num false alarms AUC0.10.20.2-0.4
Reaction time trials correct on left0.41.31.3-1.2
Reaction time trials on left0.41.41.4-1.2
Reaction time mean0.30.70.7-0.8
Reaction time mean AUC0.10.20.2-0.4
Median of all reaction times0.30.50.5-0.7
Reaction time omissions0.20.30.3-0.6
Reaction time false alarm rate0.00.00.00.2
Reaction time premature initiation rate0.20.30.3-0.6
Reaction time premature initiations0.61.71.7-1.3
Std. dev. reaction times1.03.23.2-1.8
Reaction time trials completed0.41.41.4-1.2
Reaction time trials AUC0.51.61.6-1.3
Run reversals in cocaine runway, females1.31.51.5-1.2
Run reversals in cocaine runway, males2.93.23.21.8
Latency to leave start box in cocaine runway1.72.32.31.5
Latency to leave start box in cocaine runway, F2.42.92.91.7
Latency to leave start box in cocaine runway, M0.10.10.10.2
Std. dev. time between licks in bursts0.10.10.10.4
Total sessions with >9 infusions4.75.95.9-2.4
Short access day 1 total inactive lever presses0.30.50.50.7
Short access day 10 total inactive lever presses0.00.10.1-0.3
Short access day 1 total infusions0.20.40.4-0.6
Short access day 10 total infusions0.20.30.3-0.5
Short access total infusions0.81.11.1-1.1
Short access day 1 locomotion0.40.70.7-0.9
Short access day 10 total locomotion0.62.62.6-1.6
Short access total locomotion2.23.33.3-1.8
One hour access (0.3 mA shock)0.40.50.5-0.7
Compulsive drug intake0.30.40.40.7
One hour access (shock baseline)0.41.21.2-1.1
Social response proportion1.51.91.9-1.4
Social responses5.26.96.9-2.6
Social time1.11.81.8-1.3
Soleus weight3.911.611.6-3.4
Bone: stiffness2.95.25.2-2.3
Tibialis anterior weight0.41.21.2-1.1
Time to tail flick, vehicle, before self-admin0.30.30.3-0.6
Time to tail flick, vehicle, after self-admin0.10.20.20.4
Time to tail flick, test, before self-admin0.10.10.1-0.3
Time to tail flick, test, after self-admin1.81.91.9-1.4
Delta time to tail flick, vehicle, before/after SA0.00.00.00.0
Delta time to tail flick, test, before/after SA1.62.02.0-1.4
Tibia length1.54.14.1-2.0
Ambulatory time before self-admin0.00.00.00.1
Ambulatory time after self-admin0.00.10.10.3
Bone: tissue strength0.50.50.50.7
Total heroin consumption1.21.41.4-1.2
Bone: trabecular number0.71.31.3-1.2
Bone: trabecular spacing0.30.40.40.7
Bone: trabecular thickness5.98.28.2-2.9
Bone: trabecular tissue density0.40.80.8-0.9
Water consumed over 24 hours0.10.10.1-0.4
Number of responses in last shaping day0.10.10.1-0.4