Hub : Genes

Gucy2g

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Gucy2g 0.06 0.05 9.8e-06 0.03 0.03 0.04 0.03 2.1e-04 2.2e-04 6.7e-05 1.2e-04
2 NAcc alternative TSS NM_139042.2 0.04 0.03 9.2e-05 0.02 0.04 0.03 0.03 1.7e-03 6.4e-05 8.3e-05 2.1e-04
3 LHb gene expression Gucy2g 0.44 0.18 1.2e-09 0.32 0.38 0.39 0.38 1.9e-08 5.4e-10 2.6e-10 4.1e-10
4 PL gene expression Gucy2g 0.13 0.07 6.7e-16 0.13 0.13 0.13 0.13 6.5e-14 2.0e-14 9.0e-14 5.4e-14
5 Brain gene expression Gucy2g 0.1 0.07 3.8e-08 0.08 0.08 0.08 0.08 4.1e-08 1.4e-07 4.2e-08 6.2e-08
6 NAcc gene expression Gucy2g 0.25 0.13 2.0e-14 0.12 0.12 0.13 0.12 6.8e-14 9.1e-14 8.4e-15 8.6e-14
7 Liver gene expression Gucy2g 0.06 0.04 1.1e-05 0.03 0.01 0.03 0.02 2.0e-04 1.2e-02 8.0e-04 1.2e-03
8 BLA gene expression Gucy2g 0.21 0.11 8.8e-09 0.13 0.13 0.11 0.13 1.8e-07 1.4e-07 2.5e-06 3.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.50.94.12.01.20.6-0.80.50.10.40.3
Area under the delay curve0.30.41.81.30.30.2-0.0-0.4-0.5-0.30.7
BMI with tail7.022.831.95.65.65.3-5.14.24.54.3-3.1
BMI without tail2.45.011.13.32.62.3-2.31.72.11.8-1.1
Body weight8.636.149.97.07.16.3-6.55.55.55.6-4.0
Weight adjusted by age6.16.99.22.42.82.9-2.72.53.02.4-2.1
Bone surface0.30.51.31.10.90.7-0.70.60.30.5-0.2
Bone volume1.62.76.52.52.01.8-1.71.41.01.2-0.5
Breakpoint value in progressive ratio session0.60.71.61.1-0.20.10.5-1.0-0.8-0.91.3
Number of licking bursts0.40.41.21.10.10.40.2-0.6-0.7-0.50.9
Context. condit. distance diff. score0.30.31.0-1.0-0.1-0.5-0.10.40.60.5-0.9
Locomotion velocity, session 13.33.54.4-1.2-1.9-2.12.0-1.9-2.1-1.91.7
Locomotion distance, session 10.30.31.4-1.0-0.4-1.20.2-0.0-0.2-0.1-0.2
Locomotion velocity, session 20.60.72.3-1.5-0.3-1.2-0.10.50.40.5-1.0
Locomotion distance, session 21.11.62.31.41.50.9-1.41.41.11.3-0.9
Locomotion velocity, session 30.20.20.5-0.30.2-0.6-0.30.40.60.5-0.7
Locomotion distance, session 31.21.32.6-0.30.8-0.0-1.01.51.51.3-1.6
Stereotopy head waving bouts, day 30.10.20.90.40.20.9-0.1-0.10.10.10.1
Stereotopy head waving duration, day 31.21.52.5-0.7-1.3-0.61.3-1.6-1.4-1.41.3
Locomotion velocity, session 70.00.00.30.20.1-0.6-0.00.1-0.00.00.1
Locomotion distance, session 70.10.20.5-0.50.1-0.7-0.20.50.10.4-0.5
Stereotopy head waving bouts, day 70.00.00.10.3-0.10.10.1-0.3-0.2-0.20.3
Stereotopy head waving duration, day 70.10.20.70.80.30.5-0.1-0.3-0.1-0.10.3
Locomotion velocity, session 80.91.12.6-1.6-1.1-1.60.9-0.7-0.9-0.60.2
Locomotion distance, session 80.30.40.9-0.80.1-0.8-0.40.70.60.6-0.9
Degree of sensitization distance2.12.13.6-0.4-1.3-1.11.4-1.7-1.9-1.51.7
Degree of sensitization stereotypy0.10.10.30.5-0.0-0.10.1-0.3-0.2-0.20.4
Conditioned locomotion0.00.00.1-0.30.0-0.2-0.10.30.10.1-0.2
Cocaine response after cond. corrected0.50.62.0-1.4-0.8-1.20.5-0.20.2-0.2-0.4
Cocaine response after cond. not corrected1.21.33.3-1.8-1.4-1.71.1-0.7-0.5-0.70.1
Cocaine response before conditioning1.11.32.8-0.5-1.1-0.71.2-1.1-1.7-1.21.3
Saline control response0.20.20.9-0.9-0.4-0.80.3-0.20.2-0.1-0.2
Bone: connectivity density0.20.31.3-0.3-0.4-1.10.4-0.4-0.4-0.40.4
Bone: cortical apparent density1.21.64.9-2.2-0.1-0.7-0.51.01.21.0-1.9
Bone: cortical area3.65.514.33.82.92.5-2.41.71.71.7-0.7
Bone: cortical porosity0.40.40.90.6-0.2-0.60.4-0.7-0.7-0.60.9
Bone: cortical porosity0.40.41.31.10.1-0.40.2-0.5-0.5-0.51.0
Bone: cortical thickness2.44.06.52.62.41.6-2.21.81.91.8-1.2
Bone: cortical thickness1.92.12.91.21.71.3-1.71.51.41.5-1.3
Bone: cortical tissue density1.21.65.6-2.4-0.3-0.7-0.30.91.10.9-1.8
Condit. Reinf. active minus inactive responses0.30.40.6-0.3-0.7-0.60.8-0.8-0.1-0.70.5
Condit. Reinf. active-inactive response ratio0.60.71.1-0.7-1.0-0.71.0-1.0-0.4-0.90.7
Condit. Reinf. active responses0.10.10.60.8-0.0-0.00.3-0.40.2-0.30.5
Condit. Reinf. inactive responses0.20.31.61.30.40.0-0.1-0.1-0.1-0.10.5
Incentive salience index mean0.91.11.6-0.8-1.2-1.31.3-1.1-0.5-1.10.8
Condit. Reinf. lever presses1.11.42.6-0.8-1.3-1.61.3-1.2-0.9-1.21.1
Condit. Reinf. active minus inactive responses2.93.66.60.6-1.6-1.02.0-2.3-1.8-2.42.6
Condit. Reinf. active-inactive response ratio2.82.94.5-0.1-1.7-1.02.0-2.1-1.7-2.12.1
Condit. Reinf. active responses1.72.45.51.4-0.8-0.61.4-1.8-1.5-1.92.3
Condit. Reinf. inactive responses0.30.31.51.20.2-0.40.0-0.3-0.3-0.30.8
Condit. Reinf. lever presses1.31.83.70.7-0.9-0.91.3-1.6-1.4-1.61.9
Condit. Reinf. lever reinforcers received1.82.65.61.2-1.0-0.81.5-1.9-1.6-1.92.4
Conditioned reinforcement - actives0.20.20.4-0.5-0.5-0.60.5-0.2-0.3-0.40.3
Conditioned reinforcement - inactives0.20.21.11.10.40.5-0.2-0.2-0.3-0.10.4
Conditioned locomotion0.40.51.8-0.8-0.6-0.60.5-0.4-1.3-0.40.4
Patch foraging indifference point 0 sec2.13.47.22.72.21.9-1.91.41.81.5-0.9
Patch foraging indifference point AUC0.80.92.31.4-0.00.40.4-0.6-1.2-0.71.5
Delay disc. indifference point, 0s delay0.50.61.71.31.00.8-0.90.30.30.6-0.3
Delay disc. indifference point, 16s delay0.70.71.50.5-0.5-0.60.8-1.0-1.1-1.01.2
Delay disc. indifference point, 2s delay0.10.10.10.30.30.3-0.30.2-0.30.3-0.2
Delay disc. indifference point, 24s delay1.11.12.41.3-0.20.10.6-1.0-1.4-1.01.6
Delay disc. indifference point, 4s delay0.30.30.70.4-0.3-0.50.5-0.8-0.5-0.50.6
Delay disc. indifference point, 8s delay0.91.04.92.21.01.1-0.60.0-0.10.10.5
Indifference point function ln k0.20.30.9-0.9-0.0-0.5-0.20.30.70.4-0.9
Indifference point function log k0.20.30.9-0.9-0.0-0.5-0.20.30.70.4-0.9
Patch foraging total patch changes 0 sec1.82.97.72.82.01.8-1.71.21.51.3-0.6
Patch foraging total patch changes 12 sec0.50.63.41.90.60.4-0.20.0-0.3-0.00.8
Patch foraging total patch changes 18 sec1.21.58.42.91.11.0-0.5-0.1-0.30.01.1
Patch foraging total patch changes 24 sec1.31.66.62.60.30.40.3-0.9-1.1-0.81.8
Patch foraging total patch changes 6 sec2.03.010.13.22.11.9-1.61.01.11.1-0.1
Patch foraging time to switch 0 sec0.50.72.2-1.3-0.9-1.50.7-0.6-0.1-0.3-0.1
Patch foraging water rate 0 sec0.50.81.81.11.11.3-1.00.80.60.7-0.4
Patch foraging water rate 12 sec0.60.93.01.51.01.7-0.80.30.30.5-0.1
Patch foraging water rate 18 sec1.01.42.70.71.21.6-1.21.21.21.0-0.9
Patch foraging water rate 24 sec1.62.24.01.91.82.0-1.61.21.01.2-0.8
Patch foraging water rate 6 sec0.71.01.80.11.11.3-1.11.00.41.0-1.1
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.2-0.1-0.30.1-0.2-0.5-0.10.2
Distance traveled before self-admin1.51.63.7-1.10.50.3-0.91.61.51.4-1.9
Distance traveled after self-admin3.03.45.50.01.61.3-1.92.22.02.1-2.3
Extensor digitorum longus weight0.31.33.41.81.41.3-1.11.00.80.9-0.3
Bone: elastic displacement0.10.10.60.3-0.1-0.70.2-0.2-0.1-0.20.3
Bone: elastic work1.62.12.90.91.60.7-1.61.71.71.6-1.5
Bone: endosteal estimation1.02.25.82.41.72.1-1.41.00.70.9-0.2
Bone: endosteal perimeter1.73.67.22.72.32.6-1.91.41.21.3-0.7
Epididymis fat weight9.722.545.46.75.65.5-4.83.84.03.8-2.1
Delta time in closed arm before/after self-admin0.60.61.0-0.40.40.9-0.61.00.80.8-1.0
Delta time in open arm before/after self-admin0.70.61.51.2-0.0-0.10.3-0.9-0.9-0.71.2
Diff in mean of infusions in LGA sessions2.32.53.9-1.6-1.9-2.01.8-1.6-0.9-1.61.1
Delay discount exponential model param0.40.42.0-1.4-0.3-0.30.00.50.60.3-0.8
Extinction: sum of active levers before priming1.11.12.60.3-0.7-0.60.9-1.1-1.6-1.11.4
Active lever presses in extinction session 60.20.20.90.90.40.6-0.30.0-0.40.00.3
Bone: final force1.11.83.41.81.61.7-1.41.20.81.0-0.6
Bone: final moment1.52.54.72.21.91.9-1.71.41.01.2-0.7
Food consumed during 24 hour testing period0.10.10.3-0.20.2-0.2-0.30.40.40.4-0.6
Glucose4.06.07.72.02.82.6-2.72.62.32.5-2.0
Heart weight1.82.55.41.61.71.0-1.51.42.31.4-1.3
Delay discount hyperbolic model param0.30.31.4-1.2-0.3-0.30.10.30.40.2-0.5
Intermittent access intake day 1-15 change1.11.14.22.01.21.3-0.90.40.50.40.0
Intermittent access intake escalation2.32.34.52.11.81.8-1.61.21.21.1-0.7
Intermittent access intake escalation 21.31.32.31.51.41.4-1.20.80.90.9-0.6
Intermitt. access day 1 inactive lever presses0.60.63.41.80.80.7-0.5-0.2-0.2-0.10.5
Intermitt. access day 15 inactive lever presses0.10.10.30.4-0.2-0.10.3-0.5-0.1-0.40.5
Intermitt. access escalation Index0.20.20.40.10.50.3-0.60.60.10.6-0.6
Intermittent access day 1 total infusions0.70.81.70.6-0.4-0.30.7-1.0-1.3-0.91.3
Intermittent access day 15 total infusions0.60.63.31.80.70.8-0.4-0.1-0.2-0.10.6
Intermittent access terminal intake (last 3 days)0.30.31.51.20.30.30.0-0.4-0.5-0.40.8
Intermittent access total infusions0.50.51.61.30.20.20.1-0.5-1.0-0.51.0
Intermittent access day 1 locomotion0.00.00.1-0.30.0-0.0-0.10.20.10.2-0.3
Intermittent access day 15 total locomotion0.80.82.61.61.11.2-0.90.50.60.4-0.0
Intermittent access total locomotion0.10.20.30.00.50.3-0.50.60.30.5-0.5
Intermittent access standard deviation1.11.13.61.90.30.60.1-0.8-1.2-0.81.4
Left kidney weight6.016.820.62.24.43.4-4.54.54.54.4-4.3
Right kidney weight5.816.219.73.04.43.3-4.44.24.44.2-3.9
Cocaine induced anxiety1.31.57.6-2.8-1.1-1.30.60.1-0.20.1-0.8
Post-drug Anxiety0.20.20.9-0.9-0.2-0.3-0.10.4-0.10.4-0.6
Baseline Anxiety2.52.711.43.41.92.1-1.30.50.00.50.4
Tail length0.10.31.81.40.50.2-0.30.00.30.00.3
Length with tail1.97.010.03.13.22.5-2.92.52.42.4-1.8
Length without tail5.512.016.33.34.03.6-3.93.53.23.4-2.7
Times rat made contact with spout1.11.32.01.31.41.0-1.31.11.01.1-0.8
Lifetime Intake0.60.62.11.40.20.30.2-0.6-1.0-0.61.1
Liver weight, left1.52.49.33.11.91.7-1.30.90.20.80.3
Liver weight, right5.89.715.43.93.83.5-3.42.92.12.8-1.7
Locomotor activity1.52.43.60.71.51.6-1.61.51.91.6-1.6
Locomotor testing distance2.74.46.50.62.01.8-2.22.22.62.4-2.5
Locomotor testing rearing1.21.82.70.71.31.1-1.41.41.61.5-1.5
Locomotion in novel chamber1.21.43.0-0.30.90.4-1.11.41.41.4-1.7
Locomotion in novel chamber post-restriction0.40.51.6-1.3-0.8-1.10.5-0.3-0.1-0.2-0.2
Fecal boli incidents, locomotor time 10.10.20.40.1-0.3-0.10.4-0.3-0.6-0.40.6
Change in fecal boli incidents, locomotor task0.10.10.2-0.2-0.3-0.20.2-0.20.4-0.20.0
Time >=10cm from walls, locomotor time 10.50.51.2-1.1-0.8-0.70.7-0.3-0.9-0.40.3
Bouts of movement, locomotor time 10.70.83.71.90.40.60.0-0.4-0.6-0.51.2
Total resting periods, locomotor time 10.70.73.41.90.50.7-0.1-0.3-0.5-0.41.0
Rest time, locomotor task time 10.30.30.60.60.60.8-0.60.60.50.5-0.4
Distance moved, locomotor task time 10.00.00.1-0.00.20.2-0.20.30.10.1-0.2
Vertical activity count, locomotor time 10.70.82.2-1.2-0.1-0.5-0.30.51.50.5-1.2
Time >=10cm from walls, locomotor time 20.30.31.01.00.61.0-0.40.30.00.20.1
Bouts of movement, locomotor time 20.80.91.2-1.0-1.1-1.11.0-0.8-0.8-0.90.7
Total resting periods, locomotor time 20.50.50.7-0.6-0.8-0.80.8-0.7-0.7-0.70.6
Rest time, locomotor task time 20.10.20.4-0.50.2-0.4-0.30.30.30.4-0.6
Distance moved, locomotor task time 20.30.30.90.9-0.10.50.3-0.4-0.3-0.60.9
Vertical activity count, locomotor time 20.20.20.60.60.40.7-0.30.20.70.0-0.1
Light reinforcement 10.81.52.5-1.2-1.4-1.61.3-1.0-1.0-1.21.0
Light reinforcement 21.11.52.7-1.6-1.4-1.61.2-0.8-1.0-1.10.6
Bone: marrow area1.12.46.02.51.82.2-1.41.10.81.0-0.3
Bone: maximum diameter2.95.315.33.92.82.9-2.21.51.01.4-0.3
Bone: maximum force0.91.52.51.61.51.3-1.31.10.91.0-0.7
Bone: maximum moment1.22.03.71.91.81.5-1.51.31.11.2-0.7
Mean time between licks in bursts0.30.40.80.5-0.4-0.30.6-0.7-0.4-0.80.9
Mean num. licks in bursts1.72.13.40.01.20.7-1.51.71.81.7-1.8
Cd content in liver2.62.83.9-1.5-2.0-1.71.9-1.7-1.4-1.71.3
Co content in liver0.30.40.9-0.60.30.5-0.50.70.40.7-0.9
Cu content in liver0.40.40.60.20.70.7-0.70.80.60.8-0.7
Fe content in liver0.10.10.20.50.30.3-0.30.30.50.3-0.1
K content in liver0.20.20.3-0.2-0.3-0.50.4-0.3-0.6-0.40.6
Mg content in liver0.50.51.30.4-0.3-0.20.5-0.7-1.0-0.71.1
Mn content in liver0.10.10.6-0.8-0.4-0.30.3-0.1-0.1-0.1-0.1
Na content in liver2.22.32.7-0.8-1.5-1.51.6-1.6-1.6-1.61.6
Rb content in liver1.72.23.1-0.4-1.5-1.31.6-1.6-1.6-1.61.8
Se content in liver1.21.52.5-1.1-1.3-1.61.2-1.1-1.2-1.20.9
Sr content in liver0.90.82.8-1.7-1.1-1.10.8-0.6-0.4-0.6-0.1
Zn content in liver0.80.83.6-1.9-1.0-1.10.7-0.4-0.1-0.3-0.4
Bone: minimum diameter1.93.59.53.12.32.1-1.91.31.51.3-0.6
Time in familiar zone, hab. session 10.40.31.3-1.1-0.2-0.0-0.10.30.50.4-0.9
Time in novel zone, hab. session 10.50.51.81.30.20.10.1-0.4-0.6-0.51.0
Total zone transitions, hab. session 11.42.02.61.21.61.1-1.51.61.51.4-1.2
Total locomotion distance, hab. session 10.00.00.10.30.1-0.30.0-0.1-0.2-0.10.3
Locomotion velocity, hab. session 10.00.00.10.30.0-0.30.1-0.1-0.2-0.10.2
Time in familiar zone, hab. session 21.41.45.82.41.01.9-0.50.00.30.10.7
Time in novel zone, hab. session 20.70.72.4-1.6-0.3-1.1-0.00.40.40.4-1.0
Total zone transitions, hab. session 22.22.83.71.71.91.5-1.71.71.91.6-1.3
Total locomotion distance, hab. session 21.11.52.01.41.41.0-1.31.21.31.2-0.8
Locomotion velocity, hab. session 20.70.91.21.01.10.7-1.01.01.01.0-0.7
Novel to familiar place preference ratio0.20.20.50.1-0.3-0.20.4-0.5-0.5-0.60.7
Novelty place preference0.20.20.40.3-0.2-0.10.3-0.5-0.4-0.50.7
Time in novel zone, NPP test0.20.20.60.80.00.20.2-0.5-0.4-0.50.8
Total zone transitions, NPP test1.42.03.81.91.71.5-1.41.31.11.2-0.6
Total locomotion distance, NPP test0.81.13.01.71.31.0-1.00.70.80.9-0.3
Locomotion velocity, NPP test0.50.71.11.01.00.7-0.90.80.70.9-0.6
Intraocular pressure1.72.39.13.01.71.9-1.10.71.00.60.1
Delta distance traveled before/after self-admin1.41.62.41.41.51.5-1.41.10.81.1-0.8
Delta ambulatory time before/after self-admin0.80.93.01.71.21.3-0.90.50.10.40.1
Parametrial fat weight4.07.823.64.93.33.6-2.61.81.41.6-0.3
Pavlov. Cond. lever latency0.50.62.31.10.71.5-0.50.30.30.40.1
Pavlov. Cond. magazine entry latency0.40.50.90.90.80.5-0.70.80.70.6-0.3
Pavlov. Cond. change in total contacts0.20.20.4-0.20.3-0.3-0.40.60.40.5-0.6
Pavlov. Cond. index score0.30.40.80.40.70.1-0.70.90.70.7-0.6
Pavlov. Cond. latency score0.20.30.60.20.5-0.1-0.60.80.60.6-0.6
Pavlov. Cond. lever contacts0.40.41.2-0.8-0.7-1.10.6-0.4-0.5-0.50.3
Pavlov. Cond. magazine entry number1.41.82.5-1.2-1.5-1.11.4-1.6-1.4-1.41.1
Pavlov. Cond. intertrial magazine entries0.10.10.20.50.30.3-0.30.10.40.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.40.50.1-0.50.70.40.5-0.4
Pavlov. Cond. response bias0.20.30.50.20.50.0-0.50.70.60.6-0.6
Pavlov. Cond. lever latency2.23.06.2-0.91.10.9-1.62.11.92.0-2.5
Pavlov. Cond. magazine entry latency0.50.63.31.80.90.5-0.60.10.10.30.4
Pavlov. Cond. change in total contacts1.01.33.31.6-0.3-0.50.8-1.3-0.9-1.21.8
Pavlov. Cond. index score0.70.92.81.70.1-0.20.4-0.9-0.8-0.81.4
Pavlov. Cond. latency score0.70.92.81.70.1-0.20.3-0.9-0.8-0.71.4
Pavlov. Cond. lever contacts0.81.02.41.0-0.5-0.60.8-1.2-1.0-1.11.5
Pavlov. Cond. magazine entry number0.40.53.0-1.7-0.8-0.40.4-0.00.0-0.2-0.5
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.1-0.10.30.00.0-0.3-0.10.0
Pavlov. Cond. lever-magazine prob. diff.0.60.72.41.60.1-0.10.3-0.8-0.7-0.71.3
Pavlov. Cond. response bias0.60.82.11.4-0.1-0.40.5-0.9-0.7-0.81.4
Time in closed arm before self-admin0.20.31.10.10.40.1-0.50.21.00.5-0.6
Time in closed arm after self-admin0.20.20.7-0.6-0.20.10.10.20.80.2-0.5
Time in open arm before self-admin1.31.42.5-1.5-1.3-1.21.2-0.7-1.6-0.90.7
Time in open arm after self-admin2.22.55.90.0-1.1-1.11.4-1.6-2.4-1.62.0
Bone: periosteal estimation3.16.515.43.93.13.0-2.62.01.81.9-0.8
Bone: periosteal perimeter4.37.215.63.93.33.4-2.82.11.72.0-1.0
Bone: post-yield work0.60.81.40.3-0.60.30.8-1.1-1.0-1.11.2
Progressive ratio test 1 active lever presses0.10.10.80.90.30.3-0.1-0.20.0-0.10.3
Progressive ratio test 1 breakpoint0.30.30.60.5-0.3-0.30.4-0.7-0.5-0.60.8
Progressive ratio test 1 inactive lever presses0.40.40.90.8-0.2-0.20.4-0.7-0.8-0.71.0
Progressive ratio test 2 active lever presses0.60.62.91.70.90.9-0.60.10.40.20.3
Progressive ratio test 2 breakpoint0.50.63.11.80.70.8-0.4-0.00.3-0.00.5
Progressive ratio test 2 inactive lever presses0.40.51.71.30.20.20.1-0.7-0.5-0.61.0
Incentive Sensitization - Responses0.30.31.81.30.50.5-0.2-0.10.1-0.10.5
Incentive Sensitization - Breakpoint0.30.31.91.40.50.5-0.2-0.2-0.0-0.10.6
Sum of active levers in priming session hrs 5-61.71.63.0-1.2-1.4-1.31.3-1.1-1.7-1.11.0
Progressive ratio1.31.62.3-0.8-1.4-1.21.4-1.5-0.9-1.31.2
Food seeking constrained by brief footshock1.41.83.30.1-1.2-0.91.5-1.5-1.4-1.61.8
Seeking ratio, punishment vs. effort0.20.30.50.70.60.7-0.50.60.20.3-0.1
Retroperitoneal fat weight10.032.850.57.16.76.8-6.05.05.14.9-3.3
Reaction time number correct0.60.92.91.71.11.4-0.80.50.10.50.1
Reaction time mean minus median0.10.10.20.40.30.4-0.30.1-0.00.10.1
Reaction time mean minus median AUC0.50.60.80.40.90.8-0.90.90.70.8-0.7
Reaction time num false alarms0.00.10.20.4-0.1-0.10.2-0.3-0.0-0.20.4
Reaction time num false alarms AUC0.00.00.10.20.0-0.1-0.00.00.30.10.1
Reaction time trials correct on left0.60.92.91.71.11.4-0.80.50.10.50.1
Reaction time trials on left0.70.93.01.71.11.4-0.80.60.20.50.1
Reaction time mean0.10.20.4-0.50.20.1-0.40.50.40.5-0.7
Reaction time mean AUC0.10.10.7-0.8-0.2-0.30.10.10.10.1-0.3
Median of all reaction times0.30.40.9-0.80.20.0-0.50.70.60.7-1.0
Reaction time omissions0.10.10.20.40.30.5-0.20.20.40.1-0.1
Reaction time false alarm rate0.20.30.8-0.6-0.7-0.90.6-0.5-0.0-0.50.3
Reaction time premature initiation rate1.62.13.00.31.51.0-1.71.71.41.7-1.7
Reaction time premature initiations2.73.95.11.32.21.9-2.32.21.62.2-1.8
Std. dev. reaction times0.50.71.00.81.00.9-0.90.70.80.7-0.5
Reaction time trials completed0.70.93.01.71.11.4-0.80.60.20.50.1
Reaction time trials AUC0.71.03.31.81.21.4-0.90.60.30.50.1
Run reversals in cocaine runway, females1.31.21.90.31.20.9-1.31.40.81.3-1.3
Run reversals in cocaine runway, males1.71.62.3-1.2-1.5-1.11.5-1.2-1.2-1.31.1
Latency to leave start box in cocaine runway0.50.51.1-1.1-0.8-1.00.6-0.4-0.6-0.40.2
Latency to leave start box in cocaine runway, F0.40.52.1-1.4-0.6-1.00.30.10.20.1-0.5
Latency to leave start box in cocaine runway, M0.10.10.30.4-0.00.10.2-0.3-0.5-0.50.6
Std. dev. time between licks in bursts1.51.83.10.3-1.0-0.91.3-1.5-1.7-1.61.8
Total sessions with >9 infusions2.83.14.52.02.12.1-2.01.51.21.6-1.2
Short access day 1 total inactive lever presses0.50.62.21.51.00.9-0.80.30.10.30.0
Short access day 10 total inactive lever presses0.20.20.80.90.50.5-0.4-0.00.30.10.1
Short access day 1 total infusions0.30.31.01.00.70.8-0.60.3-0.10.4-0.1
Short access day 10 total infusions0.60.61.10.3-0.5-0.70.7-0.9-1.0-0.81.0
Short access total infusions0.40.51.11.00.00.10.2-0.6-1.0-0.50.9
Short access day 1 locomotion0.20.20.40.60.10.20.0-0.3-0.7-0.30.5
Short access day 10 total locomotion1.51.72.60.11.21.0-1.41.51.31.5-1.6
Short access total locomotion0.90.91.40.20.90.8-1.01.01.01.1-1.2
One hour access (0.3 mA shock)1.41.64.82.20.30.60.3-0.8-1.5-1.01.8
Compulsive drug intake1.01.02.50.1-0.7-0.70.9-0.9-1.6-1.01.3
One hour access (shock baseline)0.50.62.01.40.91.0-0.70.40.30.30.0
Social response proportion4.44.75.71.12.32.3-2.42.32.32.3-2.2
Social responses2.32.98.22.92.02.1-1.61.11.31.0-0.3
Social time1.82.33.01.21.71.7-1.71.61.51.5-1.2
Soleus weight4.914.418.83.14.33.7-4.34.13.44.0-3.3
Bone: stiffness0.10.10.20.40.50.2-0.50.40.30.3-0.3
Tibialis anterior weight0.10.30.80.4-0.4-0.30.6-0.5-0.4-0.60.9
Time to tail flick, vehicle, before self-admin0.80.82.01.41.11.2-0.90.60.10.5-0.2
Time to tail flick, vehicle, after self-admin0.20.30.5-0.30.4-0.0-0.60.7-0.10.7-0.7
Time to tail flick, test, before self-admin2.82.83.90.31.51.3-1.72.01.91.8-2.0
Time to tail flick, test, after self-admin0.91.02.51.61.21.1-1.00.70.60.7-0.4
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.5-0.3-0.70.20.0-0.0-0.0-0.1
Delta time to tail flick, test, before/after SA0.30.31.31.20.40.5-0.2-0.3-0.4-0.10.4
Tibia length1.74.76.01.32.42.1-2.42.42.12.3-2.1
Ambulatory time before self-admin2.42.55.0-0.41.10.7-1.51.92.01.8-2.2
Ambulatory time after self-admin3.13.45.40.21.81.3-2.12.21.72.2-2.3
Bone: tissue strength0.30.30.5-0.2-0.6-0.40.7-0.5-0.5-0.60.6
Total heroin consumption0.50.63.21.80.70.8-0.3-0.10.3-0.10.5
Bone: trabecular number0.20.20.80.90.1-0.30.1-0.3-0.5-0.40.7
Bone: trabecular spacing0.20.20.3-0.3-0.6-0.30.6-0.5-0.3-0.50.5
Bone: trabecular thickness2.42.89.03.02.11.8-1.71.20.71.1-0.2
Bone: trabecular tissue density0.10.20.5-0.50.30.2-0.40.40.30.4-0.7
Water consumed over 24 hours1.11.42.00.41.20.7-1.31.31.21.4-1.4
Number of responses in last shaping day0.30.30.50.40.50.7-0.50.60.60.6-0.5