Gucy2g

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Gucy2g	0.02	0.02	2.7e-03	0.01	0.01	0.01	0.01	1.9e-02	1.9e-02	7.0e-03	1.9e-02
2	LHb	gene expression	Gucy2g	0.47	0.19	8.1e-10	0.33	0.36	0.37	0.37	1.3e-08	2.3e-09	9.8e-10	1.1e-09
3	PL	gene expression	Gucy2g	0.09	0.06	1.5e-07	0.04	0.06	0.05	0.06	1.6e-05	4.9e-07	2.5e-06	3.6e-07
4	NAcc	alternative TSS	NM_139042.2	0.04	0.03	1.2e-05	0.04	0.04	0.04	0.02	3.6e-06	3.0e-06	2.1e-06	9.5e-04
5	BLA	gene expression	Gucy2g	0.11	0.07	3.3e-05	0.08	0.06	0.04	0.07	7.3e-05	3.8e-04	3.5e-03	1.8e-04
6	Liver	gene expression	Gucy2g	0.05	0.04	2.9e-06	0.04	0.03	0.04	0.03	1.4e-05	1.9e-04	4.0e-05	1.4e-04
7	NAcc	gene expression	Gucy2g	0.29	0.14	0.0e+00	0.15	0.16	0.16	0.15	1.4e-22	1.0e-23	1.0e-23	3.3e-22
8	NAcc	alternative TSS	XM_039097497.2	0.03	0.02	4.1e-03	0	0.01	0.01	0.01	5.1e-02	3.9e-03	4.4e-03	2.3e-02
9	IC	alternative TSS	XM_039097497.2	0.11	0.13	8.0e-03	0.01	-0.01	0.01	0.02	9.5e-02	7.4e-01	8.9e-02	3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.8	1.3	5.4	-2.3	-1.5	-1.2	1.0	-0.5	-0.5	0.1	0.9	0.6
Area under the delay curve	0.4	0.5	1.3	-1.0	-0.3	-0.1	-0.1	0.4	0.3	0.7	1.1	1.0
BMI with tail	7.4	25.4	45.4	-6.7	-6.7	-6.4	5.8	-4.8	-4.7	-3.7	-1.3	-2.0
BMI without tail	4.0	12.3	21.8	-4.1	-4.7	-4.7	3.4	-3.7	-3.4	-3.1	-1.3	-1.6
Body weight	7.4	32.4	62.7	-7.9	-7.7	-7.2	6.3	-5.3	-5.3	-4.0	-1.1	-2.0
Weight adjusted by age	3.9	6.0	9.6	-1.6	-3.1	-3.1	2.6	-2.7	-2.5	-2.6	-1.6	-1.6
Bone surface	0.5	0.8	2.4	-1.6	-1.3	-1.3	0.9	-0.9	-0.6	-0.3	0.2	-0.1
Bone volume	1.8	3.2	8.8	-3.0	-2.5	-2.2	2.0	-1.5	-1.4	-0.7	0.2	-0.2
Breakpoint value in progressive ratio session	0.7	0.9	2.4	-0.9	-0.2	0.1	-0.2	0.7	0.8	1.1	1.6	1.5
Number of licking bursts	0.4	0.6	1.8	-1.0	-0.3	-0.3	-0.2	0.2	0.6	0.9	1.3	1.2
Context. condit. distance diff. score	0.5	0.6	1.5	0.9	0.3	-0.0	-0.4	-0.5	-0.5	-1.0	-1.2	-1.2
Locomotion velocity, session 1	2.7	2.9	3.8	1.6	2.0	1.8	-1.7	1.7	1.9	1.8	1.3	1.5
Locomotion distance, session 1	0.2	0.2	0.8	0.9	0.5	0.3	-0.5	-0.1	0.0	-0.3	-0.6	-0.5
Locomotion velocity, session 2	0.7	0.8	2.1	1.2	0.6	0.2	-0.2	-0.6	-0.5	-1.0	-1.5	-1.3
Locomotion distance, session 2	1.0	1.4	2.3	-1.4	-1.5	-1.5	1.2	-1.3	-1.3	-1.1	-0.5	-0.6
Locomotion velocity, session 3	0.2	0.2	0.6	0.3	0.1	-0.2	-0.3	-0.4	-0.5	-0.8	-0.7	-0.7
Locomotion distance, session 3	1.5	1.6	3.7	0.1	-0.6	-0.8	0.5	-1.1	-1.4	-1.9	-1.8	-1.8
Stereotopy head waving bouts, day 3	0.0	0.1	0.2	-0.4	-0.3	-0.2	0.3	-0.0	-0.1	0.0	0.2	0.1
Stereotopy head waving duration, day 3	1.0	1.2	1.8	0.9	1.0	1.0	-1.2	1.0	1.4	1.3	1.1	1.2
Locomotion velocity, session 7	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.0	-0.1	-0.0	-0.0	0.1	-0.0
Locomotion distance, session 7	0.2	0.2	0.6	0.4	0.0	-0.1	-0.0	-0.3	-0.4	-0.6	-0.7	-0.8
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.3	-0.2	-0.3	0.0	-0.1	0.1	0.2	0.3	0.2
Stereotopy head waving duration, day 7	0.2	0.3	0.6	-0.8	-0.5	-0.7	0.1	-0.3	0.2	0.4	0.7	0.6
Locomotion velocity, session 8	0.6	0.8	1.8	1.3	1.3	1.2	-1.0	0.6	0.7	0.4	-0.2	-0.1
Locomotion distance, session 8	0.4	0.6	1.4	0.7	0.1	-0.2	-0.3	-0.7	-0.6	-1.1	-1.2	-1.1
Degree of sensitization distance	1.8	1.9	3.5	0.7	1.1	1.2	-1.1	1.3	1.6	1.9	1.6	1.6
Degree of sensitization stereotypy	0.1	0.1	0.4	-0.3	-0.2	-0.2	-0.1	0.1	0.2	0.4	0.6	0.6
Conditioned locomotion	0.0	0.0	0.1	-0.0	0.0	0.1	0.1	-0.2	-0.3	-0.2	-0.3	-0.2
Cocaine response after cond. corrected	0.6	0.8	3.2	1.8	1.0	0.7	-1.0	0.2	0.2	-0.4	-0.9	-0.6
Cocaine response after cond. not corrected	1.1	1.3	4.5	2.1	1.6	1.3	-1.3	0.7	0.7	0.1	-0.5	-0.2
Cocaine response before conditioning	0.8	1.0	1.9	0.2	0.9	1.1	-0.5	1.1	1.1	1.4	1.0	0.9
Saline control response	0.4	0.6	1.6	1.2	1.1	1.0	-0.6	0.6	0.4	0.1	-0.4	-0.3
Bone: connectivity density	0.0	0.1	0.1	-0.1	0.2	0.2	-0.3	0.2	0.3	0.3	0.3	0.2
Bone: cortical apparent density	1.6	2.2	6.4	1.9	0.8	0.4	-0.2	-0.8	-0.8	-1.7	-2.5	-2.2
Bone: cortical area	3.3	5.1	11.4	-3.4	-3.3	-3.3	1.9	-2.4	-1.5	-0.9	0.5	0.1
Bone: cortical porosity	0.3	0.4	0.8	-0.2	0.4	0.4	-0.5	0.5	0.5	0.7	0.9	0.8
Bone: cortical porosity	0.5	0.5	1.5	-0.7	-0.0	0.2	-0.4	0.5	0.5	0.8	1.2	1.1
Bone: cortical thickness	2.2	3.6	6.7	-2.4	-2.6	-2.6	1.7	-2.2	-1.8	-1.5	-0.4	-0.7
Bone: cortical thickness	2.2	2.6	3.8	-1.7	-1.9	-1.9	1.8	-1.9	-1.7	-1.4	-0.9	-1.1
Bone: cortical tissue density	1.6	2.1	6.1	2.0	0.9	0.5	-0.3	-0.7	-0.7	-1.6	-2.5	-2.1
Condit. Reinf. active minus inactive responses	0.4	0.4	1.0	1.0	0.5	0.5	-1.0	0.4	0.7	0.3	0.4	0.6
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.7	1.3	0.9	0.7	-1.2	0.7	0.9	0.4	0.4	0.6
Condit. Reinf. active responses	0.1	0.2	0.5	-0.1	-0.1	0.0	-0.4	0.2	0.3	0.2	0.7	0.7
Condit. Reinf. inactive responses	0.3	0.3	1.2	-1.1	-0.5	-0.3	0.2	0.1	0.0	0.3	0.9	0.8
Incentive salience index mean	0.9	1.1	2.2	1.5	1.1	1.1	-1.4	1.0	1.1	0.6	0.6	0.8
Condit. Reinf. lever presses	1.0	1.4	2.0	1.2	1.3	1.4	-1.2	1.4	1.2	1.0	0.9	1.0
Condit. Reinf. active minus inactive responses	2.9	3.7	7.0	0.9	0.9	0.8	-2.4	1.3	2.3	2.1	2.6	2.6
Condit. Reinf. active-inactive response ratio	2.5	2.9	5.3	1.4	1.2	0.8	-2.3	1.2	2.1	1.7	1.9	2.0
Condit. Reinf. active responses	2.0	2.7	7.0	-0.1	0.2	0.2	-1.6	1.0	1.9	1.9	2.6	2.6
Condit. Reinf. inactive responses	0.4	0.5	1.4	-0.8	-0.3	-0.0	-0.2	0.4	0.4	0.7	1.2	1.1
Condit. Reinf. lever presses	1.2	1.7	4.1	-0.0	0.4	0.4	-1.1	0.9	1.5	1.6	2.0	1.9
Condit. Reinf. lever reinforcers received	1.9	2.7	6.5	0.0	0.3	0.3	-1.7	1.1	1.9	1.9	2.6	2.5
Conditioned reinforcement - actives	0.3	0.6	1.1	0.2	0.5	0.6	-0.8	0.8	0.9	0.8	1.0	1.0
Conditioned reinforcement - inactives	0.2	0.2	0.6	-0.8	-0.6	-0.2	0.3	0.1	0.1	0.2	0.7	0.7
Conditioned locomotion	0.1	0.2	0.6	-0.8	-0.0	-0.1	0.5	-0.4	-0.3	-0.1	-0.3	-0.5
Patch foraging indifference point 0 sec	1.3	2.4	4.6	-2.1	-2.1	-2.0	1.7	-1.4	-1.6	-1.2	-0.2	-0.6
Patch foraging indifference point AUC	1.0	1.4	3.6	-1.3	0.0	0.5	0.2	1.1	0.8	1.6	1.9	1.5
Delay disc. indifference point, 0s delay	0.6	0.7	2.4	-1.5	-1.0	-0.9	0.8	-0.6	-0.7	-0.3	0.0	-0.2
Delay disc. indifference point, 16s delay	0.7	0.8	1.8	-0.2	0.3	0.5	-0.5	0.9	0.9	1.2	1.3	1.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.5	-0.7	-0.1	-0.1	0.2	-0.1	-0.2	0.0	-0.0	-0.1
Delay disc. indifference point, 24s delay	1.4	1.5	4.2	-0.9	0.0	0.3	-0.2	1.1	1.0	1.7	2.1	1.9
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	0.1	0.3	0.2	-0.7	0.4	0.4	0.4	0.6	0.6
Delay disc. indifference point, 8s delay	0.9	1.1	4.3	-2.1	-1.2	-0.8	0.6	0.0	-0.0	0.5	1.3	1.1
Indifference point function ln k	0.2	0.4	1.2	1.1	0.3	-0.1	-0.6	-0.5	-0.2	-0.7	-0.9	-0.7
Indifference point function log k	0.2	0.4	1.2	1.1	0.3	-0.1	-0.6	-0.5	-0.2	-0.7	-0.9	-0.7
Patch foraging total patch changes 0 sec	1.1	2.2	4.8	-2.2	-2.1	-1.9	1.6	-1.2	-1.4	-0.9	0.1	-0.3
Patch foraging total patch changes 12 sec	0.4	0.5	2.4	-1.5	-0.7	-0.4	0.4	0.1	-0.1	0.5	1.1	0.7
Patch foraging total patch changes 18 sec	1.1	1.6	5.9	-2.4	-1.2	-0.7	0.8	0.2	-0.0	0.9	1.8	1.4
Patch foraging total patch changes 24 sec	1.0	1.7	4.9	-1.8	-0.4	0.2	0.1	0.9	0.6	1.4	2.2	1.8
Patch foraging total patch changes 6 sec	1.7	2.5	7.4	-2.7	-2.2	-2.0	1.7	-1.1	-1.3	-0.6	0.5	0.1
Patch foraging time to switch 0 sec	0.3	0.6	2.1	1.5	0.9	0.6	-0.9	0.0	0.1	-0.3	-0.7	-0.5
Patch foraging water rate 0 sec	0.3	0.6	2.1	-1.4	-1.0	-0.8	1.0	-0.4	-0.5	-0.2	0.2	0.0
Patch foraging water rate 12 sec	0.3	0.5	1.7	-1.3	-1.1	-0.9	0.8	-0.3	-0.5	-0.2	0.3	0.3
Patch foraging water rate 18 sec	0.6	0.9	1.5	-0.8	-1.2	-1.2	1.0	-0.9	-1.0	-1.0	-0.7	-0.7
Patch foraging water rate 24 sec	1.4	2.0	4.2	-2.1	-1.9	-1.9	1.4	-1.3	-1.2	-0.9	-0.1	-0.4
Patch foraging water rate 6 sec	0.7	1.1	1.4	-1.1	-0.8	-1.2	1.1	-1.1	-0.9	-0.9	-0.9	-1.1
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.1	0.3	0.1	-0.2	-0.1	0.1	0.2	-0.1	-0.0
Distance traveled before self-admin	2.0	2.6	6.8	0.8	-0.1	-0.6	1.0	-1.4	-1.5	-2.0	-2.5	-2.6
Distance traveled after self-admin	2.2	2.7	5.8	-0.6	-0.9	-1.2	1.7	-1.6	-1.8	-1.8	-2.1	-2.4
Extensor digitorum longus weight	0.2	0.8	2.9	-1.7	-1.1	-0.9	1.1	-0.5	-0.9	-0.4	0.2	0.0
Bone: elastic displacement	0.0	0.1	0.2	0.2	0.1	0.2	-0.4	0.2	0.0	-0.0	0.3	0.3
Bone: elastic work	1.9	2.5	3.5	-1.0	-1.6	-1.6	1.4	-1.7	-1.8	-1.9	-1.4	-1.5
Bone: endosteal estimation	1.0	2.2	6.3	-2.5	-2.1	-2.0	1.5	-1.2	-0.8	-0.2	0.7	0.3
Bone: endosteal perimeter	2.0	4.2	9.0	-3.0	-2.9	-3.0	2.0	-2.4	-1.2	-0.8	0.2	-0.1
Epididymis fat weight	4.5	15.4	38.0	-6.2	-5.9	-5.1	4.0	-3.2	-2.9	-1.7	1.1	0.6
Delta time in closed arm before/after self-admin	1.1	1.0	1.8	0.0	-0.7	-0.6	1.3	-0.9	-1.0	-1.1	-1.2	-1.3
Delta time in open arm before/after self-admin	0.7	0.7	2.0	-1.0	-0.3	-0.1	-0.0	0.6	0.5	0.9	1.3	1.4
Diff in mean of infusions in LGA sessions	1.0	1.3	4.3	2.1	1.2	1.2	-1.6	0.8	1.0	0.4	0.2	0.4
Delay discount exponential model param	0.5	0.5	1.4	1.0	0.3	0.1	0.0	-0.4	-0.3	-0.7	-1.2	-1.0
Extinction: sum of active levers before priming	1.7	1.9	3.5	0.1	0.8	1.1	-1.0	1.5	1.4	1.9	1.9	1.6
Active lever presses in extinction session 6	0.2	0.2	0.9	-0.9	-0.5	-0.4	0.7	-0.1	-0.1	0.2	0.4	0.3
Bone: final force	1.1	1.8	3.6	-1.8	-1.9	-1.9	1.5	-1.5	-0.9	-0.7	-0.0	-0.4
Bone: final moment	1.4	2.3	4.6	-2.1	-2.1	-2.1	1.7	-1.6	-1.1	-0.8	-0.0	-0.4
Food consumed during 24 hour testing period	0.2	0.3	0.7	0.2	-0.2	-0.7	-0.4	-0.7	-0.5	-0.8	-0.7	-0.7
Glucose	2.1	3.4	4.2	-1.8	-2.0	-2.0	2.0	-2.0	-1.9	-1.8	-1.4	-1.5
Heart weight	1.4	2.1	4.5	-1.5	-2.1	-1.9	1.1	-1.6	-1.3	-1.5	-0.4	-0.5
Delay discount hyperbolic model param	0.3	0.3	0.8	0.9	0.4	0.2	-0.0	-0.3	-0.2	-0.5	-0.9	-0.8
Intermittent access intake day 1-15 change	0.6	1.2	3.1	-1.8	-1.7	-1.4	1.2	-0.8	-0.8	-0.7	0.0	-0.0
Intermittent access intake escalation	0.6	1.2	3.1	-1.8	-1.7	-1.3	1.1	-0.6	-0.8	-0.7	0.1	0.1
Intermittent access intake escalation 2	0.5	0.6	1.8	-1.3	-1.2	-0.9	0.9	-0.4	-0.6	-0.4	0.1	0.2
Intermitt. access day 1 inactive lever presses	0.4	1.5	4.6	-2.1	-1.2	-0.7	0.7	0.3	0.4	0.9	1.7	1.6
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.7	0.0	-0.2	0.0	-0.2	0.3	0.5	0.3	0.6	0.8
Intermitt. access escalation Index	0.3	0.4	0.7	-0.8	-0.3	-0.5	0.8	-0.6	-0.8	-0.5	-0.6	-0.8
Intermittent access day 1 total infusions	0.2	0.4	1.3	-0.6	-0.2	0.0	-0.2	0.5	0.6	0.7	1.1	0.9
Intermittent access day 15 total infusions	0.2	0.3	0.9	-0.9	-0.9	-0.5	0.2	0.1	0.1	0.1	0.8	0.8
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.5	-0.7	-0.6	-0.3	0.2	0.0	0.0	0.1	0.5	0.5
Intermittent access total infusions	0.4	0.4	1.2	-1.1	-0.6	-0.3	0.2	0.3	0.3	0.5	1.0	0.9
Intermittent access day 1 locomotion	0.4	0.5	0.8	-0.1	-0.6	-0.8	0.5	-0.9	-0.7	-0.9	-0.8	-0.8
Intermittent access day 15 total locomotion	0.7	1.3	3.1	-1.5	-1.8	-1.5	1.4	-1.0	-0.9	-0.7	-0.1	-0.2
Intermittent access total locomotion	1.0	1.2	1.5	-0.7	-1.2	-1.2	1.1	-1.2	-1.1	-1.1	-1.0	-1.0
Intermittent access standard deviation	0.2	0.4	1.1	-1.0	-0.8	-0.4	0.3	0.3	0.3	0.5	1.0	0.9
Left kidney weight	3.4	15.7	18.9	-3.7	-4.2	-4.2	4.0	-4.2	-4.3	-4.2	-3.1	-3.5
Right kidney weight	4.0	18.2	22.7	-3.9	-4.8	-4.8	4.2	-4.5	-4.7	-4.6	-3.1	-3.4
Cocaine induced anxiety	0.7	0.9	3.2	1.8	1.4	1.0	-0.6	0.3	0.2	-0.1	-1.0	-0.9
Post-drug Anxiety	0.0	0.0	0.0	-0.1	0.2	0.1	0.1	0.1	-0.0	0.1	-0.1	-0.1
Baseline Anxiety	1.1	1.3	4.6	-2.2	-1.0	-0.6	0.4	0.2	0.3	0.8	1.6	1.4
Tail length	0.1	0.4	0.8	-0.6	-0.9	-0.9	0.0	-0.6	-0.6	-0.7	-0.1	-0.0
Length with tail	1.1	4.6	9.2	-3.0	-2.9	-2.6	2.2	-2.1	-2.2	-1.7	-0.5	-0.9
Length without tail	2.8	9.0	25.9	-5.1	-4.1	-3.5	3.6	-2.3	-2.6	-1.3	0.3	-0.5
Times rat made contact with spout	1.1	1.2	3.3	-1.8	-1.3	-1.2	1.1	-1.1	-1.1	-0.8	-0.3	-0.5
Lifetime Intake	0.4	0.5	1.4	-1.2	-0.7	-0.3	0.1	0.3	0.3	0.6	1.2	1.0
Liver weight, left	2.7	4.5	10.9	-3.3	-2.9	-2.8	2.4	-2.0	-1.8	-0.9	0.2	-0.1
Liver weight, right	7.5	13.1	21.0	-4.6	-4.4	-4.3	4.1	-3.7	-3.6	-2.9	-1.7	-2.1
Locomotor activity	1.5	2.3	3.3	-0.9	-1.4	-1.7	1.5	-1.8	-1.7	-1.6	-1.4	-1.5
Locomotor testing distance	2.3	4.1	5.8	-0.8	-1.6	-2.0	1.8	-2.4	-2.2	-2.3	-2.3	-2.3
Locomotor testing rearing	1.1	2.1	3.1	-0.9	-1.4	-1.6	1.4	-1.8	-1.5	-1.6	-1.4	-1.4
Locomotion in novel chamber	1.8	2.3	4.6	0.0	-0.6	-1.0	0.8	-1.6	-1.6	-1.9	-2.1	-2.2
Locomotion in novel chamber post-restriction	0.4	0.7	1.9	1.4	1.2	1.1	-1.0	0.6	0.4	0.1	-0.4	-0.2
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	-0.3	0.3	0.4	-0.4	0.5	0.5	0.6	0.6	0.6
Change in fecal boli incidents, locomotor task	0.2	0.2	1.5	1.2	0.2	0.3	-0.5	0.1	0.0	-0.3	-0.3	-0.2
Time >=10cm from walls, locomotor time 1	0.4	0.5	1.2	0.5	1.1	1.1	-0.7	0.8	0.5	0.6	0.1	-0.0
Bouts of movement, locomotor time 1	1.0	1.2	2.9	-1.7	-0.9	-0.3	0.3	0.5	0.5	1.0	1.7	1.5
Total resting periods, locomotor time 1	0.8	0.9	2.2	-1.5	-0.9	-0.5	0.5	0.3	0.3	0.8	1.5	1.3
Rest time, locomotor task time 1	0.3	0.4	0.8	-0.4	-0.9	-0.8	0.7	-0.6	-0.6	-0.6	-0.2	-0.2
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.2	0.1	0.1	-0.0	0.1	0.0	0.1	-0.1	-0.2
Vertical activity count, locomotor time 1	0.4	0.9	2.3	1.4	0.5	0.0	-0.6	-0.5	-0.4	-1.1	-1.5	-1.3
Time >=10cm from walls, locomotor time 2	0.3	0.4	1.8	-1.3	-0.8	-0.4	0.9	-0.1	-0.2	0.1	0.4	0.3
Bouts of movement, locomotor time 2	0.3	0.5	0.9	0.8	1.0	0.8	-0.9	0.6	0.7	0.5	0.2	0.3
Total resting periods, locomotor time 2	0.1	0.2	0.5	0.4	0.6	0.6	-0.7	0.4	0.5	0.5	0.3	0.3
Rest time, locomotor task time 2	0.2	0.2	0.6	-0.1	0.1	-0.3	0.0	-0.6	-0.5	-0.6	-0.8	-0.7
Distance moved, locomotor task time 2	0.4	0.5	1.2	-0.5	-0.1	0.3	-0.3	0.8	0.7	0.8	1.1	1.1
Vertical activity count, locomotor time 2	0.1	0.1	0.4	-0.6	-0.5	-0.4	0.3	-0.1	0.1	-0.1	0.1	0.1
Light reinforcement 1	0.5	1.2	2.0	1.4	1.3	1.2	-1.3	0.9	1.2	1.0	0.4	0.5
Light reinforcement 2	0.6	1.0	2.4	1.5	1.3	1.1	-1.3	0.6	1.1	0.7	0.0	0.1
Bone: marrow area	1.0	2.2	6.5	-2.6	-2.2	-2.0	1.5	-1.2	-0.8	-0.3	0.6	0.3
Bone: maximum diameter	3.0	5.6	15.6	-3.9	-3.4	-3.2	2.2	-2.2	-1.3	-0.4	1.0	0.6
Bone: maximum force	0.7	1.3	2.9	-1.4	-1.6	-1.7	1.0	-1.4	-0.7	-0.6	-0.0	-0.3
Bone: maximum moment	0.9	1.5	3.2	-1.7	-1.8	-1.8	1.2	-1.4	-0.8	-0.7	0.0	-0.2
Mean time between licks in bursts	0.2	0.5	1.2	-0.1	0.2	0.3	-0.8	0.6	0.7	0.7	1.1	1.1
Mean num. licks in bursts	1.4	2.2	3.7	-0.5	-1.0	-1.0	1.3	-1.3	-1.8	-1.9	-1.9	-1.9
Cd content in liver	1.8	2.0	5.3	1.1	-0.2	-0.6	0.6	-1.3	-1.2	-1.9	-2.3	-2.1
Co content in liver	0.5	0.6	1.8	0.8	0.7	0.7	0.3	0.1	-0.5	-0.8	-1.3	-1.2
Cu content in liver	0.0	0.0	0.1	0.0	0.2	0.2	0.1	-0.1	-0.1	-0.2	-0.4	-0.4
Fe content in liver	0.3	0.4	1.1	-0.9	-0.6	-0.2	0.1	0.3	0.1	0.5	1.0	0.9
K content in liver	0.5	0.5	1.1	0.4	0.9	1.1	-0.5	1.0	0.5	0.7	0.4	0.3
Mg content in liver	0.3	0.3	0.6	0.1	0.5	0.7	-0.5	0.7	0.6	0.8	0.6	0.6
Mn content in liver	0.0	0.1	0.2	0.5	0.3	0.1	-0.2	0.0	0.1	-0.0	-0.2	-0.2
Na content in liver	1.7	1.8	2.5	1.3	1.6	1.2	-1.5	1.2	1.6	1.4	1.0	1.1
Rb content in liver	2.1	2.4	3.7	1.2	1.5	1.7	-1.7	1.9	1.5	1.6	1.4	1.4
Se content in liver	1.3	1.5	2.3	1.4	1.5	1.4	-1.5	1.2	1.3	1.1	0.6	0.7
Sr content in liver	0.9	0.8	2.4	1.6	1.2	0.9	-0.9	0.4	0.4	-0.2	-0.9	-0.6
Zn content in liver	0.2	0.3	0.5	0.6	0.7	0.7	-0.1	0.3	-0.1	-0.3	-0.7	-0.6
Bone: minimum diameter	1.8	3.2	7.4	-2.7	-2.6	-2.5	1.6	-1.8	-1.1	-0.7	0.5	0.2
Time in familiar zone, hab. session 1	0.6	0.6	1.6	1.0	0.4	-0.1	-0.2	-0.5	-0.4	-0.8	-1.3	-1.1
Time in novel zone, hab. session 1	0.8	0.8	2.2	-1.1	-0.6	-0.3	-0.0	0.2	0.5	1.0	1.5	1.3
Total zone transitions, hab. session 1	1.4	1.9	3.0	-1.3	-1.6	-1.7	1.4	-1.5	-1.5	-1.4	-0.8	-1.0
Total locomotion distance, hab. session 1	0.0	0.0	0.2	-0.2	-0.1	-0.2	-0.2	-0.0	0.1	0.2	0.4	0.3
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.2	0.1	0.1	0.1	0.3	0.3
Time in familiar zone, hab. session 2	1.1	1.2	2.8	-1.7	-1.4	-1.1	0.7	-0.2	-0.1	0.5	1.4	1.3
Time in novel zone, hab. session 2	0.8	0.8	2.2	1.1	0.7	0.4	-0.3	-0.3	-0.4	-0.9	-1.5	-1.4
Total zone transitions, hab. session 2	1.8	2.3	3.5	-1.4	-1.9	-1.9	1.5	-1.6	-1.7	-1.6	-0.8	-0.9
Total locomotion distance, hab. session 2	0.9	1.1	1.9	-1.2	-1.4	-1.3	1.0	-1.1	-1.2	-1.0	-0.4	-0.5
Locomotion velocity, hab. session 2	0.5	0.7	1.1	-0.9	-1.1	-1.1	0.8	-0.9	-1.0	-0.8	-0.4	-0.5
Novel to familiar place preference ratio	0.2	0.3	0.5	0.0	0.3	0.4	-0.2	0.5	0.6	0.7	0.7	0.7
Novelty place preference	0.2	0.2	0.5	-0.1	0.1	0.2	-0.1	0.4	0.5	0.7	0.7	0.7
Time in novel zone, NPP test	0.3	0.4	1.1	-0.5	-0.2	0.0	-0.0	0.4	0.5	0.7	1.0	1.0
Total zone transitions, NPP test	1.2	1.7	3.3	-1.8	-1.8	-1.6	1.5	-1.2	-1.3	-0.9	-0.1	-0.3
Total locomotion distance, NPP test	0.6	0.8	1.8	-1.4	-1.3	-1.2	0.8	-0.8	-0.9	-0.6	0.2	0.1
Locomotion velocity, NPP test	0.4	0.6	1.1	-0.9	-1.0	-1.0	0.7	-0.8	-0.9	-0.7	-0.2	-0.3
Intraocular pressure	1.3	1.8	4.7	-2.1	-2.2	-1.8	1.1	-0.9	-0.8	-0.4	0.8	0.6
Delta distance traveled before/after self-admin	0.8	0.9	2.5	-1.6	-1.3	-1.0	1.3	-0.7	-0.6	-0.3	0.0	-0.2
Delta ambulatory time before/after self-admin	0.7	0.9	3.5	-1.9	-1.1	-0.7	0.9	-0.1	-0.1	0.5	0.9	0.7
Parametrial fat weight	4.2	9.9	29.5	-5.4	-4.6	-4.1	3.1	-2.1	-1.9	-0.8	1.5	1.0
Pavlov. Cond. lever latency	0.2	0.3	0.7	-0.9	-0.8	-0.8	0.4	-0.5	-0.4	-0.1	0.3	0.1
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	-0.8	-0.6	-0.3	0.8	-0.2	-0.5	-0.3	0.0	-0.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	-0.0	-0.1	-0.1	0.4	-0.4	-0.5	-0.6	-0.6	-0.6
Pavlov. Cond. index score	0.2	0.3	0.7	-0.5	-0.5	-0.3	0.8	-0.3	-0.7	-0.6	-0.5	-0.5
Pavlov. Cond. latency score	0.2	0.2	0.5	-0.4	-0.3	-0.2	0.7	-0.3	-0.6	-0.6	-0.5	-0.5
Pavlov. Cond. lever contacts	0.3	0.4	0.9	1.0	0.8	0.8	-0.5	0.6	0.6	0.3	-0.1	0.1
Pavlov. Cond. magazine entry number	1.2	1.5	2.4	1.4	1.3	1.0	-1.6	1.0	1.5	1.3	0.8	0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.2	-0.4	-0.6	0.0	-0.3	-0.3	-0.4	-0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.5	-0.5	-0.3	-0.1	0.7	-0.1	-0.5	-0.4	-0.3	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.0	-0.1	0.1	0.4	-0.0	-0.3	-0.4	-0.4	-0.4
Pavlov. Cond. lever latency	1.8	2.5	5.9	0.1	-0.6	-0.8	1.2	-1.4	-1.7	-2.0	-2.4	-2.3
Pavlov. Cond. magazine entry latency	0.6	0.8	3.5	-1.9	-1.0	-0.6	0.8	-0.1	-0.3	0.3	1.0	0.7
Pavlov. Cond. change in total contacts	1.2	1.8	5.1	-0.5	0.1	0.3	-1.1	1.2	1.2	1.6	2.3	2.1
Pavlov. Cond. index score	1.0	1.3	4.1	-1.1	-0.3	-0.1	-0.4	0.6	0.9	1.3	2.0	1.8
Pavlov. Cond. latency score	0.9	1.3	3.9	-1.3	-0.5	-0.1	-0.2	0.6	0.7	1.3	2.0	1.7
Pavlov. Cond. lever contacts	1.0	1.4	3.6	-0.2	0.4	0.4	-1.0	0.9	1.2	1.5	1.9	1.8
Pavlov. Cond. magazine entry number	0.5	0.7	2.6	1.6	0.8	0.5	-0.5	-0.1	0.1	-0.4	-1.1	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.5	0.1	-0.4	-0.6	0.2	-0.7	0.0	-0.2	-0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	3.3	-1.2	-0.4	-0.2	-0.2	0.5	0.7	1.1	1.8	1.6
Pavlov. Cond. response bias	1.0	1.4	4.0	-0.7	0.0	0.2	-0.8	0.9	1.0	1.4	2.0	1.8
Time in closed arm before self-admin	0.1	0.2	0.9	0.9	0.4	0.1	-0.7	0.0	-0.0	-0.3	-0.3	0.0
Time in closed arm after self-admin	0.4	0.4	1.7	1.3	0.4	0.2	-0.3	-0.2	-0.2	-0.7	-0.8	-0.6
Time in open arm before self-admin	0.5	0.6	1.2	0.4	1.1	1.1	-0.6	0.7	0.8	0.9	0.4	0.2
Time in open arm after self-admin	1.2	1.3	2.8	-0.9	0.4	0.6	-0.3	1.1	1.1	1.7	1.7	1.4
Bone: periosteal estimation	2.8	5.9	14.3	-3.8	-3.5	-3.4	2.4	-2.4	-1.7	-0.9	0.5	0.0
Bone: periosteal perimeter	4.2	7.3	17.0	-4.1	-3.8	-3.8	2.7	-2.8	-1.8	-1.0	0.4	-0.1
Bone: post-yield work	0.8	1.1	2.5	-0.1	0.4	0.4	-0.6	0.8	1.3	1.4	1.6	1.6
Progressive ratio test 1 active lever presses	0.4	0.5	1.7	-0.7	-0.5	-0.2	-0.1	0.6	0.5	0.6	1.3	1.2
Progressive ratio test 1 breakpoint	0.5	0.6	1.7	-0.6	-0.4	-0.2	-0.2	0.6	0.5	0.7	1.3	1.2
Progressive ratio test 1 inactive lever presses	0.9	1.3	3.6	-1.2	-0.4	0.1	-0.2	0.9	1.0	1.3	1.9	1.8
Progressive ratio test 2 active lever presses	0.7	0.8	2.5	-1.6	-1.4	-0.8	0.7	-0.0	-0.1	0.2	1.0	0.9
Progressive ratio test 2 breakpoint	0.8	0.9	2.9	-1.7	-1.5	-0.9	0.9	-0.1	-0.2	0.1	0.9	0.9
Progressive ratio test 2 inactive lever presses	0.5	0.9	2.2	-1.5	-0.9	-0.4	0.3	0.3	0.4	0.7	1.4	1.3
Incentive Sensitization - Responses	0.5	0.8	2.9	-1.7	-1.3	-0.7	0.9	-0.1	-0.2	0.2	0.8	0.7
Incentive Sensitization - Breakpoint	0.5	0.7	2.7	-1.6	-1.2	-0.6	0.9	-0.1	-0.2	0.2	0.7	0.7
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.4	0.4	0.9	1.0	-0.6	0.9	1.0	1.2	0.9	0.7
Progressive ratio	0.8	1.2	1.6	1.3	1.2	1.0	-1.3	1.0	1.1	1.1	0.8	1.1
Food seeking constrained by brief footshock	1.7	2.1	3.5	0.3	1.0	1.1	-1.4	1.5	1.6	1.7	1.9	1.8
Seeking ratio, punishment vs. effort	0.2	0.3	1.2	-1.1	-0.8	-0.6	0.6	-0.4	-0.4	-0.3	0.0	-0.3
Retroperitoneal fat weight	5.2	22.0	59.0	-7.7	-6.9	-5.9	5.2	-3.5	-3.3	-1.7	1.4	0.8
Reaction time number correct	0.4	0.9	3.6	-1.9	-1.1	-0.9	0.9	-0.3	-0.5	0.1	0.7	0.6
Reaction time mean minus median	0.1	0.2	0.4	-0.6	-0.5	-0.5	0.5	-0.5	-0.2	0.0	0.1	0.1
Reaction time mean minus median AUC	0.3	0.8	1.3	-0.8	-1.0	-1.0	1.1	-1.1	-0.9	-0.8	-0.7	-0.7
Reaction time num false alarms	0.1	0.1	0.2	-0.1	-0.1	0.2	0.1	0.4	0.2	0.3	0.4	0.4
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.0	-0.1	0.2	0.2	0.3	0.0	0.0	0.1	0.1
Reaction time trials correct on left	0.4	0.9	3.6	-1.9	-1.1	-0.9	0.9	-0.3	-0.5	0.1	0.7	0.6
Reaction time trials on left	0.5	0.9	3.6	-1.9	-1.2	-1.0	0.9	-0.4	-0.5	0.1	0.7	0.6
Reaction time mean	0.3	0.5	1.1	0.1	-0.4	-0.5	0.7	-0.9	-0.6	-0.8	-1.0	-1.0
Reaction time mean AUC	0.1	0.2	0.7	0.6	0.1	-0.1	0.2	-0.5	-0.2	-0.5	-0.8	-0.7
Median of all reaction times	0.6	0.8	1.9	0.3	-0.3	-0.5	0.7	-1.0	-0.7	-1.0	-1.4	-1.3
Reaction time omissions	0.1	0.1	0.4	0.1	-0.5	-0.6	0.1	-0.4	0.1	-0.1	0.2	0.2
Reaction time false alarm rate	0.2	0.3	1.1	1.0	0.6	0.8	-0.5	0.6	0.5	0.2	0.0	0.1
Reaction time premature initiation rate	1.5	2.0	3.0	-1.0	-1.0	-1.0	1.7	-1.4	-1.7	-1.5	-1.6	-1.7
Reaction time premature initiations	1.9	3.3	5.2	-2.2	-1.8	-1.7	2.3	-1.7	-2.1	-1.6	-1.3	-1.6
Std. dev. reaction times	0.5	0.9	1.5	-1.0	-1.2	-1.2	1.1	-1.1	-0.8	-0.7	-0.3	-0.4
Reaction time trials completed	0.5	0.9	3.6	-1.9	-1.2	-1.0	0.9	-0.4	-0.5	0.1	0.7	0.6
Reaction time trials AUC	0.5	0.9	3.7	-1.9	-1.2	-1.0	0.9	-0.4	-0.5	0.0	0.7	0.6
Run reversals in cocaine runway, females	1.5	1.5	2.2	-1.5	-1.2	-1.3	1.3	-1.3	-1.2	-1.1	-0.9	-1.0
Run reversals in cocaine runway, males	1.2	1.2	1.6	1.2	1.2	1.2	-1.1	1.1	1.2	1.1	0.8	0.9
Latency to leave start box in cocaine runway	0.3	0.4	0.9	0.9	0.9	0.7	-0.8	0.3	0.5	0.2	-0.2	-0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	1.7	1.3	1.0	0.7	-0.8	0.2	0.2	-0.1	-0.6	-0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	-0.2	-0.1	0.1	-0.0	0.2	0.2	0.3	0.3
Std. dev. time between licks in bursts	1.6	2.1	4.0	0.1	0.8	0.8	-1.5	1.4	1.6	1.8	2.0	2.0
Total sessions with >9 infusions	0.8	1.0	2.6	-1.6	-1.5	-1.3	0.9	-0.7	-0.7	-0.6	0.2	-0.0
Short access day 1 total inactive lever presses	0.6	0.8	3.3	-1.8	-0.9	-0.4	0.8	0.2	0.2	0.7	1.1	0.9
Short access day 10 total inactive lever presses	0.2	0.6	1.3	-1.0	-1.1	-0.9	1.1	-0.7	-0.5	-0.4	-0.0	-0.0
Short access day 1 total infusions	0.2	0.2	0.9	-0.9	-0.6	-0.4	0.5	-0.0	-0.1	0.1	0.4	0.3
Short access day 10 total infusions	0.4	0.5	0.9	0.4	0.4	0.5	-0.8	0.7	0.8	0.7	0.9	0.8
Short access total infusions	0.2	0.2	0.7	-0.7	-0.3	-0.2	-0.1	0.3	0.3	0.4	0.8	0.6
Short access day 1 locomotion	0.3	0.4	0.9	-0.9	-0.4	-0.1	0.2	0.3	0.4	0.7	1.0	0.8
Short access day 10 total locomotion	1.5	2.8	3.8	-0.7	-1.4	-1.7	1.7	-1.9	-1.7	-1.8	-1.7	-1.9
Short access total locomotion	1.0	1.2	1.6	-0.7	-1.2	-1.2	1.1	-1.2	-1.2	-1.3	-1.0	-1.2
One hour access (0.3 mA shock)	3.0	3.5	9.6	-1.6	-0.1	0.5	-0.4	1.6	1.7	2.5	3.1	2.7
Compulsive drug intake	1.3	1.6	3.5	-0.9	0.5	0.7	-0.5	1.2	1.2	1.8	1.9	1.6
One hour access (shock baseline)	0.1	0.1	0.4	-0.4	-0.7	-0.5	0.3	-0.1	-0.1	0.0	0.4	0.3
Social response proportion	4.2	4.7	6.1	-1.9	-2.2	-2.2	2.5	-2.3	-2.3	-2.3	-1.9	-2.1
Social responses	1.7	2.2	6.9	-2.6	-2.2	-1.6	1.9	-0.9	-1.0	-0.4	0.6	0.3
Social time	1.4	1.9	3.6	-1.6	-1.6	-1.2	1.9	-1.2	-1.4	-1.2	-0.8	-1.0
Soleus weight	4.7	14.0	18.7	-4.3	-4.2	-3.9	4.3	-3.7	-4.1	-3.4	-2.3	-2.8
Bone: stiffness	0.1	0.2	0.9	-0.1	-0.5	-0.9	-0.0	-0.9	0.0	-0.2	-0.1	-0.2
Tibialis anterior weight	0.2	0.7	1.5	-0.0	0.7	0.9	-0.5	1.2	0.7	0.9	1.1	1.1
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.3	-1.1	-0.7	-0.7	0.8	-0.6	-0.6	-0.3	-0.2	-0.3
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.5	0.6	0.5	-0.5	0.4	0.4	0.6	0.3	0.3
Time to tail flick, test, before self-admin	1.4	1.4	2.5	0.1	-0.7	-0.9	1.1	-1.3	-1.2	-1.4	-1.5	-1.6
Time to tail flick, test, after self-admin	0.3	0.3	1.0	-1.0	-0.2	-0.2	0.1	0.3	0.3	0.6	0.9	0.7
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.3	0.1	0.7	0.8	-1.1	1.0	0.9	1.1	1.1	1.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.7	-0.7	0.1	0.2	-0.3	0.5	0.4	0.6	0.8	0.8
Tibia length	1.8	5.1	7.6	-2.0	-2.5	-2.8	2.3	-2.7	-2.3	-2.0	-1.5	-1.8
Ambulatory time before self-admin	2.3	3.4	7.2	0.3	-0.8	-1.2	1.4	-1.8	-1.9	-2.4	-2.6	-2.7
Ambulatory time after self-admin	2.7	3.2	5.1	-1.3	-1.3	-1.5	2.1	-1.8	-1.9	-1.7	-2.0	-2.2
Bone: tissue strength	0.4	0.4	0.7	0.8	0.6	0.7	-0.8	0.7	0.6	0.3	0.3	0.4
Total heroin consumption	0.8	0.9	2.4	-1.5	-1.5	-1.2	0.8	-0.4	-0.3	-0.3	0.7	0.6
Bone: trabecular number	0.2	0.4	1.1	-1.1	-0.4	-0.2	0.1	0.2	0.3	0.6	1.1	0.8
Bone: trabecular spacing	0.2	0.3	0.6	0.8	0.6	0.6	-0.5	0.5	0.5	0.4	0.3	0.4
Bone: trabecular thickness	2.5	3.1	10.7	-3.3	-2.4	-2.0	2.0	-1.1	-1.1	-0.2	0.8	0.4
Bone: trabecular tissue density	0.1	0.2	0.5	0.6	0.1	-0.4	-0.0	-0.7	-0.1	-0.3	-0.6	-0.5
Water consumed over 24 hours	1.1	1.5	2.5	-0.9	-1.2	-1.5	0.8	-1.6	-1.3	-1.3	-1.1	-1.3
Number of responses in last shaping day	0.0	0.0	0.1	-0.0	-0.2	-0.0	-0.1	0.2	-0.0	-0.2	0.1	0.3