Hub : Genes

Casp7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Casp7 0.59 0.18 1.5e-03 0.11 0.08 0.03 0.02 1.0e-02 2.7e-02 1.2e-01 1.6e-01
2 NAcc gene expression Casp7 0.11 0.06 3.4e-15 0.1 0.1 0.1 0.1 4.9e-15 2.8e-14 1.4e-14 1.7e-14
3 PL gene expression Casp7 0.12 0.06 2.8e-16 0.14 0.14 0.13 0.14 1.2e-14 1.6e-14 1.9e-14 9.9e-15
4 LHb gene expression Casp7 0.14 0.1 5.9e-03 0 0.05 0.01 0.01 2.9e-01 2.6e-02 1.7e-01 1.5e-01
5 pVTA mRNA stability Casp7 0.28 0.11 0.0e+00 0.32 0.34 0.32 0.33 2.1e-26 7.0e-28 1.9e-26 5.4e-27
6 IC gene expression Casp7 0.07 0.05 3.6e-03 0.06 0.05 0.03 0.06 2.4e-03 3.3e-03 2.6e-02 2.0e-03
7 Brain gene expression Casp7 0.11 0.06 1.1e-12 0.12 0.14 0.13 0.12 1.0e-11 9.9e-13 8.5e-12 1.3e-11
8 Adipose gene expression Casp7 0.18 0.09 1.8e-12 0.09 -0 0.1 0.06 1.4e-10 3.8e-01 3.0e-11 2.5e-07
9 Adipose mRNA stability Casp7 0.14 0.08 1.2e-04 0.03 0 0.03 0.02 4.1e-04 9.8e-02 1.1e-04 6.0e-03
10 Brain mRNA stability Casp7 0.14 0.09 4.3e-07 0.06 0.07 0.07 0.07 3.2e-06 1.7e-07 1.8e-07 2.6e-07
11 NAcc mRNA stability Casp7 0.1 0.05 1.2e-11 0.07 0.08 0.07 0.08 3.0e-11 1.7e-12 2.4e-11 1.4e-11
12 pVTA gene expression Casp7 0.26 0.1 0.0e+00 0.31 0.3 0.29 0.3 4.0e-25 4.7e-24 2.2e-23 5.6e-25
13 LHb mRNA stability Casp7 0.2 0.13 5.8e-03 0.04 0.08 -0 0.02 4.6e-02 6.9e-03 3.9e-01 8.7e-02
14 PL mRNA stability Casp7 0.14 0.06 3.5e-10 0.09 0.1 0.09 0.09 2.4e-10 2.3e-11 3.5e-10 2.2e-10
15 NAcc intron excision ratio chr1_265449781_265472451 0.02 0.02 2.7e-03 0.01 0.01 0.01 0.01 3.7e-03 3.4e-02 7.6e-03 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.73.25.7-2.0-1.91.72.2-1.61.61.4-0.9-1.62.22.4-0.42.12.1-1.7
Area under the delay curve0.40.61.1-0.8-0.90.90.8-0.90.70.4-0.3-0.30.81.1-0.31.00.8-0.9
BMI with tail9.232.255.1-7.4-6.87.17.1-6.56.06.5-6.0-5.94.54.1-4.93.03.0-3.3
BMI without tail3.317.531.7-5.6-5.05.55.1-5.04.45.0-4.9-4.12.82.5-4.11.71.7-1.6
Body weight10.847.177.1-8.8-8.58.38.3-7.47.17.4-7.3-7.56.05.5-5.74.04.1-4.4
Weight adjusted by age2.16.111.6-3.0-3.13.12.9-3.33.43.3-2.6-2.01.60.5-2.51.00.9-0.0
Bone surface0.71.42.7-1.5-1.41.11.5-1.00.91.0-0.8-1.61.31.5-0.71.01.1-1.1
Bone volume2.44.77.4-2.7-2.62.32.7-2.22.12.1-1.7-2.42.22.4-1.41.91.9-1.4
Breakpoint value in progressive ratio session0.20.41.2-0.7-0.70.80.5-0.60.20.1-0.2-0.20.51.1-0.10.80.5-0.7
Number of licking bursts0.30.92.4-0.6-0.91.00.9-0.70.20.3-0.6-1.21.11.6-0.11.11.0-1.5
Context. condit. distance diff. score0.70.82.10.70.4-0.8-1.01.4-1.4-0.8-0.1-0.9-0.9-0.60.1-1.4-1.10.8
Locomotion velocity, session 11.01.13.71.31.2-1.1-1.00.5-0.5-0.91.71.9-0.7-0.81.10.0-0.20.8
Locomotion distance, session 10.60.82.90.70.4-0.6-0.6-0.30.30.20.81.1-1.1-1.7-0.6-1.0-1.11.5
Locomotion velocity, session 20.91.13.40.70.2-0.5-0.70.1-0.10.2-0.30.1-1.2-1.9-1.1-1.7-1.61.8
Locomotion distance, session 20.91.34.0-1.3-1.11.30.9-1.81.21.4-0.4-0.1-0.7-0.5-2.0-0.5-0.91.2
Locomotion velocity, session 30.60.74.10.3-0.30.0-0.2-0.50.30.5-0.20.2-0.8-1.3-1.2-1.0-1.12.0
Locomotion distance, session 31.01.13.5-0.1-0.40.2-0.2-0.40.20.7-0.8-0.4-1.1-1.6-1.6-1.6-1.61.9
Stereotopy head waving bouts, day 30.10.10.40.10.10.30.2-0.30.30.2-0.30.60.3-0.00.30.40.40.1
Stereotopy head waving duration, day 30.40.52.00.90.7-0.5-0.30.40.0-0.50.31.10.70.21.41.01.0-0.5
Locomotion velocity, session 70.30.30.6-0.5-0.70.40.6-0.40.60.4-0.4-0.80.50.5-0.40.40.4-0.8
Locomotion distance, session 70.10.10.50.1-0.1-0.2-0.20.4-0.3-0.1-0.3-0.7-0.4-0.3-0.4-0.6-0.5-0.6
Stereotopy head waving bouts, day 70.00.00.2-0.2-0.30.30.2-0.00.10.0-0.1-0.30.10.40.00.20.10.5
Stereotopy head waving duration, day 70.50.61.1-0.7-0.90.91.0-0.80.90.6-0.4-0.41.01.0-0.11.11.0-0.0
Locomotion velocity, session 81.41.63.41.41.1-1.6-1.61.8-1.8-1.51.0-0.0-1.2-0.70.8-1.3-1.10.9
Locomotion distance, session 80.81.23.90.40.3-0.6-0.90.8-1.1-0.50.3-0.5-1.6-1.1-0.8-2.0-1.91.4
Degree of sensitization distance0.91.03.80.40.6-0.5-0.41.2-1.0-1.20.8-0.00.41.31.40.80.8-2.0
Degree of sensitization stereotypy0.10.10.6-0.4-0.30.40.4-0.10.1-0.00.2-0.30.20.80.10.50.4-0.1
Conditioned locomotion0.10.10.30.40.4-0.2-0.40.3-0.3-0.2-0.1-0.1-0.5-0.60.1-0.5-0.50.1
Cocaine response after cond. corrected2.43.56.91.71.9-1.7-2.01.2-1.5-1.21.32.0-2.6-2.50.2-2.2-2.42.3
Cocaine response after cond. not corrected2.53.75.42.12.1-2.0-2.21.6-1.8-1.51.41.9-2.3-2.30.7-2.0-2.02.0
Cocaine response before conditioning0.60.72.40.70.2-0.5-0.10.8-0.3-0.7-0.0-0.51.11.01.00.91.2-1.6
Saline control response0.50.82.31.20.8-1.0-1.10.4-0.3-0.51.00.7-1.0-1.50.0-0.8-0.90.5
Bone: connectivity density0.20.30.9-0.0-0.1-0.20.40.20.1-0.10.1-0.60.80.80.50.70.9-0.9
Bone: cortical apparent density1.72.79.81.31.1-1.2-1.50.7-0.5-0.1-0.30.8-2.1-3.1-0.8-2.6-2.52.0
Bone: cortical area8.113.121.7-4.7-4.44.34.5-4.34.04.0-3.3-3.23.33.0-2.82.72.6-2.1
Bone: cortical porosity0.10.10.6-0.2-0.10.30.00.0-0.2-0.2-0.3-0.10.10.6-0.00.20.1-0.8
Bone: cortical porosity0.50.62.0-0.8-0.70.90.7-0.40.10.1-0.5-0.70.71.4-0.10.90.7-1.4
Bone: cortical thickness4.27.011.3-3.4-3.33.13.2-3.33.23.2-2.7-2.42.11.5-2.41.51.4-1.2
Bone: cortical thickness2.63.26.8-2.2-2.32.22.0-2.01.92.2-2.6-2.30.90.5-2.10.20.2-0.4
Bone: cortical tissue density1.82.910.01.51.2-1.3-1.70.9-0.7-0.3-0.10.9-2.2-3.2-0.6-2.7-2.52.1
Condit. Reinf. active minus inactive responses0.20.21.20.30.4-0.3-0.2-0.30.10.00.91.1-0.5-0.6-0.0-0.2-0.40.3
Condit. Reinf. active-inactive response ratio0.20.21.30.60.4-0.6-0.30.0-0.1-0.21.10.8-0.2-0.40.4-0.0-0.00.0
Condit. Reinf. active responses0.30.41.5-0.4-0.10.50.7-1.21.10.80.31.00.40.0-0.20.80.5-0.2
Condit. Reinf. inactive responses0.81.12.5-0.9-0.51.11.2-1.51.61.1-0.40.71.10.6-0.21.41.2-0.9
Incentive salience index mean0.50.72.60.80.9-0.8-0.7-0.1-0.1-0.31.51.6-1.0-1.10.2-0.4-0.70.3
Condit. Reinf. lever presses0.40.62.50.90.9-0.8-0.70.0-0.0-0.41.41.6-0.8-0.90.5-0.2-0.4-0.3
Condit. Reinf. active minus inactive responses1.42.27.6-0.4-0.20.71.2-1.41.40.60.51.22.01.51.22.82.5-1.8
Condit. Reinf. active-inactive response ratio0.40.72.50.10.40.20.4-0.40.4-0.10.91.10.80.81.21.61.4-0.9
Condit. Reinf. active responses2.84.111.0-1.0-1.11.42.0-2.12.21.3-0.30.52.92.10.63.33.1-2.8
Condit. Reinf. inactive responses1.42.14.6-0.7-1.30.91.5-1.41.61.1-0.9-0.42.21.5-0.12.02.0-2.1
Condit. Reinf. lever presses0.81.12.6-0.9-0.81.11.1-1.31.10.7-0.20.01.21.40.21.61.3-1.2
Condit. Reinf. lever reinforcers received2.13.08.5-0.9-0.91.11.7-1.91.91.10.00.72.31.80.72.92.7-2.3
Conditioned reinforcement - actives0.20.82.70.10.1-0.1-0.5-1.00.40.01.31.7-1.2-0.9-0.8-0.3-1.11.5
Conditioned reinforcement - inactives0.20.51.5-0.7-0.80.70.7-1.21.10.60.10.40.50.5-0.40.80.5-0.5
Conditioned locomotion0.91.34.2-0.1-0.20.1-0.5-0.90.40.40.50.9-1.6-1.6-1.6-1.2-1.72.0
Patch foraging indifference point 0 sec1.64.67.2-2.7-2.52.52.7-2.52.62.3-1.8-1.92.01.7-1.41.81.7-1.5
Patch foraging indifference point AUC0.20.41.7-0.10.10.10.2-0.4-0.1-0.31.30.90.30.90.61.20.8-0.1
Delay disc. indifference point, 0s delay0.60.71.8-1.2-1.01.30.8-0.90.60.8-1.2-0.70.10.5-0.90.0-0.2-0.3
Delay disc. indifference point, 16s delay0.10.20.7-0.2-0.40.20.1-0.30.1-0.20.5-0.20.40.7-0.10.70.5-0.8
Delay disc. indifference point, 2s delay0.10.10.4-0.0-0.10.2-0.20.4-0.6-0.3-0.3-0.2-0.40.2-0.2-0.5-0.6-0.1
Delay disc. indifference point, 24s delay0.91.44.8-0.8-1.00.90.8-0.60.50.00.3-0.81.51.90.21.71.5-2.2
Delay disc. indifference point, 4s delay0.10.10.3-0.1-0.00.1-0.10.1-0.4-0.40.40.1-0.10.50.10.1-0.0-0.6
Delay disc. indifference point, 8s delay1.72.96.3-1.9-1.92.02.0-2.52.41.8-1.0-0.31.61.3-1.01.91.6-0.6
Indifference point function ln k0.10.21.00.10.2-0.10.00.30.30.3-1.0-0.30.1-0.50.1-0.4-0.1-0.7
Indifference point function log k0.10.21.00.10.2-0.10.00.30.30.3-1.0-0.30.1-0.50.1-0.4-0.1-0.7
Patch foraging total patch changes 0 sec1.64.67.2-2.6-2.52.52.7-2.52.52.2-1.7-1.82.11.9-1.21.91.9-1.6
Patch foraging total patch changes 12 sec0.91.22.8-1.2-1.21.21.3-1.10.70.6-0.2-0.81.21.7-0.11.61.3-0.7
Patch foraging total patch changes 18 sec1.22.96.3-1.9-1.61.72.0-2.11.81.30.2-0.21.82.1-0.22.52.1-1.5
Patch foraging total patch changes 24 sec0.51.94.6-1.6-1.41.31.5-1.61.30.80.2-0.21.51.9-0.22.11.7-0.9
Patch foraging total patch changes 6 sec3.35.69.0-2.8-2.82.63.0-3.02.72.5-1.5-1.72.32.2-1.62.32.1-1.5
Patch foraging time to switch 0 sec0.20.71.40.90.6-0.8-1.00.9-1.0-0.70.30.1-1.0-0.9-0.1-1.2-1.11.2
Patch foraging water rate 0 sec0.20.81.3-0.9-0.70.91.1-0.91.11.0-0.7-0.41.10.6-0.11.01.1-1.0
Patch foraging water rate 12 sec0.52.27.3-1.0-1.11.01.6-0.91.41.0-1.2-0.92.01.60.11.92.1-2.7
Patch foraging water rate 18 sec0.30.81.8-0.9-1.00.90.9-1.11.21.1-1.3-0.80.3-0.1-1.2-0.1-0.0-0.2
Patch foraging water rate 24 sec1.21.64.0-2.0-1.51.81.5-1.61.21.6-1.5-1.10.10.4-1.6-0.0-0.10.0
Patch foraging water rate 6 sec0.40.63.2-0.8-0.71.00.8-0.80.81.1-1.8-0.60.1-0.2-0.8-0.3-0.20.2
Seeking ratio, delayed vs. immediate footshock0.40.51.60.20.4-0.2-0.70.4-0.8-0.50.20.1-1.2-0.6-0.4-1.1-1.31.2
Distance traveled before self-admin0.61.34.80.60.6-0.6-0.90.8-0.8-0.0-0.7-0.1-1.4-1.8-0.7-2.2-1.91.2
Distance traveled after self-admin0.81.44.6-0.4-0.40.4-0.3-0.3-0.30.5-0.7-1.2-1.6-1.4-1.7-2.0-2.11.5
Extensor digitorum longus weight0.41.52.6-1.3-1.21.01.4-0.81.00.8-0.6-1.51.61.6-0.21.41.5-1.6
Bone: elastic displacement0.00.00.1-0.20.00.10.00.1-0.0-0.20.3-0.10.10.40.20.20.1-0.2
Bone: elastic work1.21.63.6-1.6-1.51.41.2-1.41.21.6-1.5-1.6-0.0-0.2-1.9-0.6-0.60.8
Bone: endosteal estimation1.43.56.5-2.6-2.42.42.4-2.01.51.8-1.9-2.01.52.0-1.61.31.2-0.6
Bone: endosteal perimeter3.89.315.8-4.0-3.93.73.8-3.73.33.5-3.0-2.82.52.1-3.01.91.8-0.9
Epididymis fat weight8.040.659.4-7.5-7.57.47.7-6.56.56.2-5.7-6.26.86.2-3.85.45.6-5.5
Delta time in closed arm before/after self-admin0.20.20.8-0.00.10.1-0.2-0.1-0.10.2-0.30.3-0.7-0.7-0.5-0.8-0.90.3
Delta time in open arm before/after self-admin0.50.61.6-0.8-0.70.70.9-0.70.70.40.1-0.71.01.10.11.31.2-0.4
Diff in mean of infusions in LGA sessions0.71.32.71.31.6-1.3-1.21.6-1.5-1.40.81.3-0.7-0.31.2-0.5-0.30.5
Delay discount exponential model param0.50.71.30.91.0-1.0-0.80.9-0.7-0.40.20.4-0.9-1.10.4-1.0-0.81.0
Extinction: sum of active levers before priming0.40.52.10.70.7-0.7-0.80.5-0.8-1.11.41.0-0.30.30.80.40.1-0.3
Active lever presses in extinction session 60.30.31.1-0.5-0.70.70.4-1.00.70.6-0.60.00.20.1-0.80.1-0.1-0.0
Bone: final force2.33.77.6-2.8-2.52.22.3-2.52.22.4-1.7-2.01.10.9-2.00.90.7-0.6
Bone: final moment2.74.39.5-3.1-2.72.42.5-2.62.22.5-1.8-2.21.21.2-2.10.90.7-0.7
Food consumed during 24 hour testing period0.10.10.8-0.10.00.2-0.00.2-0.30.1-0.7-0.9-0.0-0.1-0.2-0.5-0.3-0.3
Glucose2.13.36.6-1.8-2.31.82.0-1.72.02.2-2.5-2.61.80.7-1.70.71.0-0.7
Heart weight2.43.96.6-2.6-2.22.42.5-2.11.92.1-2.1-1.91.91.8-1.11.51.6-1.5
Delay discount hyperbolic model param0.40.50.90.80.9-0.9-0.70.8-0.6-0.40.30.4-0.7-1.00.4-0.8-0.60.8
Intermittent access intake day 1-15 change0.42.44.4-1.9-2.02.01.6-2.12.02.0-1.9-1.00.60.1-2.00.1-0.00.0
Intermittent access intake escalation0.42.13.9-1.9-1.91.91.6-2.01.91.9-1.6-0.80.90.4-1.70.30.3-0.1
Intermittent access intake escalation 20.71.22.8-1.4-1.31.41.0-1.51.41.5-1.3-0.60.0-0.3-1.7-0.3-0.40.6
Intermitt. access day 1 inactive lever presses0.22.86.0-2.0-1.91.91.8-1.51.40.9-0.6-1.11.92.5-0.42.11.8-2.1
Intermitt. access day 15 inactive lever presses0.00.31.4-0.5-0.40.50.3-0.70.50.30.30.20.30.4-0.30.60.3-1.2
Intermitt. access escalation Index0.00.10.3-0.2-0.10.30.10.2-0.10.1-0.5-0.50.10.20.1-0.2-0.10.4
Intermittent access day 1 total infusions0.10.41.5-0.6-0.80.70.2-1.20.60.40.40.4-0.5-0.0-1.00.2-0.50.3
Intermittent access day 15 total infusions0.30.82.6-1.1-1.31.20.7-1.61.11.0-0.30.1-0.00.1-1.40.1-0.30.2
Intermittent access terminal intake (last 3 days)0.20.41.3-0.7-0.90.90.4-1.10.60.6-0.4-0.0-0.2-0.0-1.1-0.1-0.50.4
Intermittent access total infusions0.70.83.3-1.0-1.21.20.7-1.81.31.0-0.00.5-0.00.1-1.20.5-0.10.2
Intermittent access day 1 locomotion0.30.51.9-0.5-0.70.60.0-0.90.40.5-0.1-0.0-0.9-0.7-1.4-0.7-1.10.4
Intermittent access day 15 total locomotion0.72.85.0-1.9-2.12.02.0-2.22.21.9-1.5-0.81.61.0-1.41.21.1-0.9
Intermittent access total locomotion0.91.13.2-1.0-1.21.20.7-1.41.31.4-1.1-0.3-0.3-0.8-1.8-0.6-0.80.7
Intermittent access standard deviation0.10.81.5-1.1-1.01.21.0-1.21.10.8-0.6-0.40.70.9-0.50.90.6-0.6
Left kidney weight1.19.218.4-4.1-3.83.83.3-3.12.53.6-4.3-4.00.70.9-3.9-0.6-0.50.5
Right kidney weight2.215.326.9-4.9-5.04.84.2-4.54.04.9-5.1-4.91.41.0-5.2-0.2-0.20.2
Cocaine induced anxiety1.64.47.82.12.4-2.1-2.62.5-2.8-2.21.00.6-2.6-1.80.9-2.5-2.41.3
Post-drug Anxiety0.30.30.90.30.8-0.3-0.51.0-0.9-0.7-0.2-0.6-0.20.20.7-0.4-0.2-0.4
Baseline Anxiety2.33.87.3-1.8-1.81.82.2-1.92.31.6-0.9-1.02.72.1-0.12.52.6-2.0
Tail length0.21.22.4-1.5-1.51.51.1-1.20.91.0-1.3-1.20.81.0-1.20.50.5-0.3
Length with tail1.87.813.3-3.5-3.73.33.2-2.82.82.8-3.0-3.32.62.4-2.31.71.8-1.8
Length without tail2.915.524.9-4.7-5.04.34.7-4.04.13.8-3.4-4.14.13.9-2.73.13.2-3.1
Times rat made contact with spout0.50.61.6-1.2-0.81.10.7-1.10.60.9-0.4-0.4-0.30.1-1.1-0.3-0.5-0.3
Lifetime Intake0.91.14.0-1.2-1.41.40.8-2.01.41.2-0.10.3-0.10.0-1.40.4-0.20.5
Liver weight, left5.69.717.8-4.2-3.83.83.8-3.32.93.2-3.4-3.62.62.9-2.71.71.7-1.8
Liver weight, right5.49.517.5-4.2-3.84.03.5-3.83.03.8-3.7-3.40.91.1-4.00.1-0.1-0.4
Locomotor activity1.32.14.4-1.3-1.91.51.4-1.61.91.9-2.1-1.80.9-0.0-1.80.00.20.0
Locomotor testing distance0.81.94.7-1.2-1.51.31.1-1.61.82.0-2.2-1.10.2-1.0-2.0-0.7-0.60.8
Locomotor testing rearing0.41.53.9-1.2-1.51.21.1-1.31.31.6-2.0-1.60.3-0.3-1.8-0.5-0.40.4
Locomotion in novel chamber0.81.03.70.0-0.0-0.1-0.40.0-0.30.3-0.5-0.6-1.5-1.4-1.3-1.9-1.91.2
Locomotion in novel chamber post-restriction0.72.14.01.71.6-1.5-1.71.0-1.0-1.11.21.5-1.9-2.00.4-1.5-1.61.4
Fecal boli incidents, locomotor time 10.30.72.30.3-0.20.00.6-0.71.30.50.10.61.30.20.51.51.5-1.3
Change in fecal boli incidents, locomotor task0.90.93.00.40.8-0.6-1.01.3-1.7-1.10.80.0-1.2-0.10.2-1.3-1.20.6
Time >=10cm from walls, locomotor time 11.41.83.21.51.8-1.6-1.41.7-1.7-1.51.31.3-1.0-0.61.5-0.7-0.60.6
Bouts of movement, locomotor time 10.91.12.8-1.4-0.91.31.2-1.20.80.6-0.00.11.01.7-0.01.61.3-0.8
Total resting periods, locomotor time 10.80.92.1-1.4-0.91.31.1-1.20.70.60.1-0.10.71.4-0.31.30.9-0.5
Rest time, locomotor task time 10.20.41.0-0.9-0.50.80.5-1.00.50.70.1-0.1-0.7-0.4-0.9-0.3-0.70.4
Distance moved, locomotor task time 10.10.10.60.2-0.0-0.20.00.3-0.0-0.1-0.4-0.70.80.40.40.30.5-0.4
Vertical activity count, locomotor time 10.10.41.30.90.6-0.9-0.71.1-0.7-0.5-0.5-0.3-0.2-0.60.5-0.9-0.40.4
Time >=10cm from walls, locomotor time 20.10.41.6-0.6-0.40.70.7-0.10.10.1-0.7-0.40.81.30.30.70.8-0.9
Bouts of movement, locomotor time 20.41.33.60.90.8-1.0-1.41.6-1.9-1.50.5-0.5-1.3-0.30.6-1.2-1.21.2
Total resting periods, locomotor time 20.20.82.20.50.4-0.6-1.01.1-1.5-1.10.4-0.6-1.1-0.20.2-1.0-1.11.2
Rest time, locomotor task time 20.10.20.60.0-0.40.20.1-0.30.50.5-0.5-0.60.0-0.6-0.8-0.4-0.30.5
Distance moved, locomotor task time 20.20.31.2-0.3-0.10.20.3-0.50.4-0.00.20.40.70.80.51.10.9-0.8
Vertical activity count, locomotor time 20.10.30.8-0.4-0.30.40.6-0.30.40.3-0.8-0.00.70.70.40.70.8-0.9
Light reinforcement 10.52.23.71.21.5-1.5-1.71.6-1.9-1.61.91.0-1.7-0.81.0-1.3-1.41.3
Light reinforcement 21.32.84.61.41.7-1.6-2.01.8-2.1-1.81.81.1-2.1-1.20.7-1.7-1.91.6
Bone: marrow area1.53.76.7-2.6-2.42.42.4-2.11.51.9-1.9-2.11.52.0-1.71.31.2-0.6
Bone: maximum diameter7.214.522.6-4.8-4.64.44.7-4.43.94.0-3.3-3.43.83.5-2.73.23.0-2.4
Bone: maximum force1.73.46.7-2.6-2.42.12.2-2.32.02.2-1.8-2.01.20.9-2.00.80.7-0.5
Bone: maximum moment2.03.88.2-2.9-2.62.32.3-2.42.02.3-1.8-2.21.21.2-2.00.90.7-0.6
Mean time between licks in bursts0.00.20.80.0-0.20.10.2-0.0-0.2-0.20.1-0.30.50.90.40.70.6-0.6
Mean num. licks in bursts0.30.82.4-0.5-0.00.1-0.1-0.50.50.7-0.20.5-1.1-1.5-1.0-1.4-1.41.5
Cd content in liver1.21.44.40.60.9-0.6-1.00.7-0.6-0.2-0.30.2-1.7-2.0-0.4-2.1-1.91.5
Co content in liver0.91.02.61.31.4-1.2-0.90.9-0.5-0.40.61.3-1.1-1.60.8-0.9-0.70.3
Cu content in liver0.20.20.40.50.5-0.4-0.40.3-0.2-0.2-0.00.5-0.6-0.60.2-0.6-0.5-0.5
Fe content in liver1.01.23.3-0.9-0.60.51.0-0.60.70.30.3-0.01.61.60.51.81.8-1.6
K content in liver0.50.51.01.00.7-0.9-0.80.9-0.7-0.91.00.8-0.5-0.30.7-0.2-0.30.1
Mg content in liver0.40.40.80.60.7-0.5-0.70.7-0.9-0.80.80.7-0.60.00.6-0.3-0.40.3
Mn content in liver0.40.41.00.90.6-0.6-0.71.0-1.0-0.80.1-0.1-0.6-0.20.4-0.7-0.60.6
Na content in liver0.40.51.00.90.5-0.9-0.81.0-0.9-1.00.90.5-0.20.10.70.00.0-0.1
Rb content in liver1.51.84.01.51.7-1.2-1.41.7-1.8-1.91.21.4-0.40.32.00.10.1-0.9
Se content in liver0.70.81.51.21.0-1.2-1.11.2-1.1-1.10.90.8-0.3-0.31.0-0.2-0.10.5
Sr content in liver2.72.44.31.21.5-1.6-1.81.5-1.4-1.21.31.1-2.1-1.80.6-1.9-1.91.7
Zn content in liver1.11.31.91.31.2-1.3-1.31.2-1.2-1.01.00.7-1.4-1.20.5-1.3-1.30.5
Bone: minimum diameter3.77.212.7-3.6-3.13.43.3-2.82.32.6-2.7-2.62.42.7-1.82.12.0-1.9
Time in familiar zone, hab. session 10.20.20.90.70.3-0.7-0.40.40.3-0.0-0.1-0.1-0.1-0.90.2-0.4-0.2-0.0
Time in novel zone, hab. session 10.70.82.4-1.2-1.01.21.0-0.90.50.5-0.3-0.50.91.6-0.41.10.9-0.6
Total zone transitions, hab. session 11.21.73.9-1.8-1.51.81.3-1.81.41.7-1.3-0.80.0-0.0-2.0-0.2-0.40.8
Total locomotion distance, hab. session 10.10.10.4-0.4-0.10.60.1-0.2-0.20.1-0.40.1-0.40.2-0.3-0.3-0.50.7
Locomotion velocity, hab. session 10.10.20.6-0.20.20.3-0.2-0.0-0.5-0.10.00.4-0.7-0.0-0.1-0.5-0.70.7
Time in familiar zone, hab. session 21.92.15.5-1.5-1.01.21.7-1.41.30.90.3-0.31.62.10.22.01.9-2.3
Time in novel zone, hab. session 21.01.14.10.70.4-0.5-0.90.5-0.4-0.1-0.70.1-1.2-1.8-0.6-1.5-1.52.0
Total zone transitions, hab. session 21.41.74.4-1.7-1.61.71.4-1.91.61.8-1.0-0.80.10.1-2.1-0.1-0.30.5
Total locomotion distance, hab. session 20.50.71.6-1.1-0.81.30.8-1.20.51.0-0.9-0.3-0.40.1-1.2-0.4-0.60.8
Locomotion velocity, hab. session 20.40.51.3-0.8-0.61.00.6-0.90.40.8-0.7-0.3-0.4-0.0-1.1-0.5-0.70.8
Novel to familiar place preference ratio0.10.20.6-0.0-0.10.10.20.1-0.0-0.20.1-0.20.70.80.40.70.7-0.5
Novelty place preference0.20.20.8-0.2-0.30.30.3-0.10.1-0.0-0.1-0.30.70.90.30.70.7-0.3
Time in novel zone, NPP test0.50.62.0-0.6-0.70.60.8-0.40.40.2-0.2-0.51.21.40.21.21.2-0.8
Total zone transitions, NPP test0.81.23.1-1.7-1.41.51.1-1.60.71.2-0.5-0.7-0.30.5-1.8-0.3-0.60.7
Total locomotion distance, NPP test0.40.61.7-1.3-0.81.30.7-1.00.00.7-0.4-0.3-0.50.5-1.1-0.4-0.70.6
Locomotion velocity, NPP test0.40.51.6-0.8-0.30.80.2-0.5-0.40.4-0.3-0.1-1.1-0.1-1.0-1.1-1.31.1
Intraocular pressure2.64.28.4-2.3-2.02.42.6-2.92.72.2-0.7-0.22.01.7-0.92.42.0-1.5
Delta distance traveled before/after self-admin0.70.82.3-1.2-1.11.20.6-1.00.40.7-0.5-1.5-0.40.2-1.4-0.4-0.70.7
Delta ambulatory time before/after self-admin0.50.82.2-1.4-1.31.30.9-1.10.50.6-0.3-1.50.31.0-0.90.40.10.2
Parametrial fat weight10.825.339.4-6.0-5.45.96.3-5.45.44.9-4.2-3.95.25.0-2.44.84.7-4.7
Pavlov. Cond. lever latency0.20.20.7-0.4-0.40.30.4-0.10.20.00.0-0.20.80.90.20.80.8-0.3
Pavlov. Cond. magazine entry latency0.20.30.5-0.7-0.60.70.5-0.70.30.6-0.5-0.4-0.10.2-0.7-0.2-0.3-0.6
Pavlov. Cond. change in total contacts0.10.10.3-0.1-0.10.10.2-0.00.10.3-0.2-0.5-0.2-0.2-0.3-0.4-0.3-0.0
Pavlov. Cond. index score0.20.30.7-0.5-0.70.60.5-0.60.40.7-0.7-0.8-0.0-0.1-0.9-0.3-0.3-0.1
Pavlov. Cond. latency score0.20.20.5-0.4-0.50.40.4-0.50.30.6-0.5-0.6-0.2-0.3-0.7-0.4-0.40.0
Pavlov. Cond. lever contacts0.10.10.40.50.4-0.3-0.30.1-0.1-0.00.20.3-0.4-0.60.1-0.3-0.30.0
Pavlov. Cond. magazine entry number1.01.32.31.41.4-1.4-1.31.5-1.2-1.51.41.2-0.4-0.21.40.00.10.5
Pavlov. Cond. intertrial magazine entries0.10.10.7-0.10.20.00.2-0.50.60.30.40.8-0.0-0.30.10.20.10.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.4-0.4-0.50.50.4-0.50.30.6-0.5-0.70.0-0.0-0.7-0.2-0.2-0.4
Pavlov. Cond. response bias0.10.20.5-0.3-0.40.40.3-0.50.30.6-0.5-0.3-0.2-0.4-0.7-0.4-0.5-0.4
Pavlov. Cond. lever latency0.50.82.50.60.4-0.7-0.70.9-0.7-0.2-0.6-0.4-0.9-1.4-0.5-1.6-1.21.1
Pavlov. Cond. magazine entry latency1.21.83.3-1.5-1.81.71.5-1.31.21.0-0.9-1.71.31.8-1.01.10.9-0.5
Pavlov. Cond. change in total contacts0.61.43.9-0.9-0.91.11.2-1.51.20.60.30.31.31.60.22.01.6-1.3
Pavlov. Cond. index score1.11.73.0-1.4-1.51.61.5-1.71.41.0-0.2-0.51.31.7-0.51.71.3-1.0
Pavlov. Cond. latency score1.11.83.3-1.4-1.61.61.5-1.71.41.0-0.3-0.61.31.8-0.61.61.3-1.0
Pavlov. Cond. lever contacts0.30.51.3-0.7-0.60.90.7-1.00.70.40.20.20.61.10.01.10.8-0.6
Pavlov. Cond. magazine entry number1.11.42.61.51.6-1.5-1.41.3-1.1-0.90.61.2-1.1-1.60.9-1.0-0.80.4
Pavlov. Cond. intertrial magazine entries0.10.21.2-0.4-0.20.40.4-0.20.10.3-0.7-0.30.40.2-0.20.10.2-1.1
Pavlov. Cond. lever-magazine prob. diff.1.11.73.2-1.4-1.51.61.5-1.81.51.1-0.4-0.51.21.6-0.71.51.2-0.8
Pavlov. Cond. response bias0.81.12.5-1.0-1.01.31.2-1.31.00.6-0.1-0.31.21.6-0.11.61.2-0.7
Time in closed arm before self-admin0.20.32.9-0.0-0.2-0.2-0.10.7-0.6-0.2-0.3-1.7-0.10.2-0.0-0.5-0.20.1
Time in closed arm after self-admin0.60.72.00.40.5-0.5-0.90.8-1.2-0.70.2-0.6-1.3-0.6-0.2-1.4-1.40.6
Time in open arm before self-admin0.91.12.41.31.2-1.2-1.31.2-1.3-1.31.01.6-0.7-0.50.8-0.5-0.5-0.1
Time in open arm after self-admin0.30.31.20.00.2-0.10.1-0.30.3-0.21.01.00.40.40.51.10.8-0.4
Bone: periosteal estimation4.711.319.8-4.5-4.24.14.2-3.93.33.7-3.3-3.32.72.9-2.92.22.1-1.6
Bone: periosteal perimeter8.015.725.0-5.0-4.94.74.9-4.94.44.6-3.5-3.43.52.9-3.42.82.7-2.1
Bone: post-yield work0.20.31.8-0.5-0.30.20.20.1-0.6-0.40.0-0.30.11.10.20.40.2-1.3
Progressive ratio test 1 active lever presses0.50.93.9-1.2-1.21.30.6-2.01.10.90.20.2-0.40.0-1.50.3-0.50.6
Progressive ratio test 1 breakpoint0.50.93.8-1.1-1.21.30.6-2.01.10.90.20.3-0.4-0.0-1.50.3-0.50.7
Progressive ratio test 1 inactive lever presses0.20.51.7-0.9-1.01.10.6-1.30.80.5-0.0-0.00.40.7-0.50.80.3-0.3
Progressive ratio test 2 active lever presses1.31.85.1-1.6-1.91.71.3-2.31.81.6-0.8-0.40.60.4-1.70.60.20.3
Progressive ratio test 2 breakpoint1.51.95.4-1.6-1.91.81.4-2.31.91.6-0.9-0.40.70.5-1.70.70.30.3
Progressive ratio test 2 inactive lever presses0.51.62.8-1.4-1.51.51.4-1.71.61.3-0.8-0.71.21.0-0.71.21.0-1.5
Incentive Sensitization - Responses0.51.32.4-1.2-1.61.31.3-1.41.41.3-1.1-0.71.20.8-0.90.90.9-0.6
Incentive Sensitization - Breakpoint0.51.22.1-1.1-1.41.21.3-1.31.41.2-1.0-0.51.30.8-0.80.90.9-0.6
Sum of active levers in priming session hrs 5-60.90.81.81.11.2-1.1-1.00.9-1.0-1.01.11.3-0.6-0.51.0-0.1-0.20.5
Progressive ratio0.20.71.91.01.0-1.0-0.90.6-0.7-0.91.41.3-0.5-0.40.7-0.1-0.20.6
Food seeking constrained by brief footshock0.50.61.30.80.6-0.7-0.60.7-0.6-1.11.10.20.60.91.10.70.7-0.6
Seeking ratio, punishment vs. effort0.20.41.4-0.7-0.80.70.6-0.30.40.4-0.9-1.20.40.6-0.30.10.2-0.3
Retroperitoneal fat weight11.250.076.2-8.6-8.08.58.7-7.47.37.0-6.4-6.37.36.9-4.06.06.1-6.0
Reaction time number correct0.41.32.2-1.4-1.31.21.3-1.01.00.9-0.9-1.01.31.3-0.61.21.2-1.5
Reaction time mean minus median0.10.52.1-0.4-0.70.80.6-1.41.21.0-0.60.30.1-0.4-0.80.2-0.10.8
Reaction time mean minus median AUC0.11.02.1-0.6-0.90.90.5-1.41.01.2-1.1-0.3-0.5-0.8-1.5-0.7-0.91.4
Reaction time num false alarms0.10.10.6-0.00.40.0-0.10.0-0.1-0.20.50.4-0.50.00.1-0.1-0.30.8
Reaction time num false alarms AUC0.10.10.9-0.10.20.2-0.1-0.20.1-0.00.10.3-0.6-0.2-0.2-0.3-0.51.0
Reaction time trials correct on left0.41.32.2-1.4-1.31.21.3-1.01.00.9-0.9-1.01.31.3-0.61.21.2-1.5
Reaction time trials on left0.41.42.3-1.4-1.41.21.4-1.11.01.0-1.0-1.01.31.4-0.61.21.2-1.5
Reaction time mean0.20.41.20.2-0.40.50.3-0.81.00.9-1.10.10.2-0.9-0.7-0.2-0.20.7
Reaction time mean AUC0.10.20.80.60.00.0-0.1-0.40.50.4-0.60.3-0.1-0.9-0.3-0.3-0.20.6
Median of all reaction times0.20.31.30.3-0.20.30.1-0.50.80.7-1.1-0.10.1-1.0-0.7-0.4-0.30.7
Reaction time omissions0.20.30.6-0.8-0.50.50.7-0.70.60.50.1-0.30.50.70.10.70.6-0.7
Reaction time false alarm rate0.40.51.60.60.9-0.4-0.70.4-0.5-0.60.70.8-1.0-0.60.3-0.6-0.81.3
Reaction time premature initiation rate0.60.93.0-0.7-0.70.80.3-0.80.70.9-1.1-0.3-0.7-1.0-1.4-1.0-1.11.7
Reaction time premature initiations0.51.63.6-1.5-1.51.51.1-1.51.41.6-1.8-0.9-0.0-0.4-1.9-0.4-0.51.0
Std. dev. reaction times0.51.74.9-1.1-1.41.61.4-2.22.01.8-1.4-0.20.8-0.0-1.30.60.40.2
Reaction time trials completed0.41.42.3-1.4-1.41.21.4-1.11.01.0-1.0-1.01.31.4-0.61.21.2-1.5
Reaction time trials AUC0.41.52.2-1.5-1.41.31.4-1.21.11.0-1.0-1.01.31.4-0.71.31.2-1.5
Run reversals in cocaine runway, females0.80.92.0-0.9-1.31.01.0-1.41.41.3-0.7-0.80.1-0.2-1.3-0.1-0.20.5
Run reversals in cocaine runway, males0.90.92.31.11.0-1.1-1.11.5-1.5-1.40.90.3-0.50.11.0-0.4-0.3-0.5
Latency to leave start box in cocaine runway0.60.81.41.10.8-1.0-1.21.0-1.0-0.91.00.7-0.8-0.90.2-0.9-0.80.7
Latency to leave start box in cocaine runway, F0.81.01.91.21.2-1.2-1.31.4-1.3-1.10.80.4-0.8-0.90.6-1.0-0.80.4
Latency to leave start box in cocaine runway, M0.10.10.6-0.3-0.60.40.1-0.50.30.20.10.1-0.00.1-0.8-0.1-0.20.5
Std. dev. time between licks in bursts0.20.41.40.60.7-0.3-0.40.3-0.8-0.91.20.9-0.60.60.80.40.00.3
Total sessions with >9 infusions2.12.67.2-2.0-2.02.11.7-2.72.32.1-1.3-0.40.50.2-1.80.60.11.0
Short access day 1 total inactive lever presses0.40.71.9-1.0-1.11.00.8-0.60.30.4-0.6-0.91.01.4-0.20.70.7-1.1
Short access day 10 total inactive lever presses0.10.71.2-1.1-1.01.11.0-0.91.00.9-1.1-0.80.70.6-0.60.30.4-0.4
Short access day 1 total infusions0.30.61.6-0.9-0.91.00.5-1.10.80.9-0.6-0.3-0.3-0.2-1.1-0.3-0.61.3
Short access day 10 total infusions0.30.62.60.1-0.10.1-0.3-0.90.40.20.40.9-1.0-0.9-0.8-0.4-1.01.6
Short access total infusions0.60.92.9-0.9-0.91.00.4-1.71.11.0-0.00.4-0.7-0.6-1.4-0.3-0.91.5
Short access day 1 locomotion0.30.62.3-0.8-0.81.00.5-1.50.90.8-0.10.0-0.2-0.2-1.10.1-0.41.0
Short access day 10 total locomotion0.31.33.1-1.3-1.31.31.1-1.21.11.6-1.7-1.10.0-0.4-1.6-0.5-0.4-0.2
Short access total locomotion0.91.33.5-1.2-1.11.30.7-1.71.21.4-0.8-0.3-0.7-0.8-1.9-0.6-1.01.2
One hour access (0.3 mA shock)1.11.32.8-1.2-1.31.31.0-1.71.30.70.20.01.11.4-0.41.61.1-0.9
Compulsive drug intake0.30.51.7-0.3-0.2-0.00.20.0-0.2-0.40.90.30.71.30.51.00.9-1.3
One hour access (shock baseline)0.30.82.2-0.9-1.01.20.7-1.51.31.1-0.8-0.30.1-0.1-1.20.2-0.20.6
Social response proportion2.43.07.5-2.2-2.21.81.4-1.91.62.1-2.0-2.0-0.3-0.6-2.7-1.0-1.11.3
Social responses4.15.410.4-2.9-3.02.92.7-3.22.92.7-2.2-1.71.71.4-2.11.61.3-0.7
Social time1.42.24.9-1.6-2.11.71.4-1.81.61.8-1.7-1.80.50.1-2.2-0.1-0.20.4
Soleus weight3.29.315.1-3.7-3.93.83.4-3.53.43.8-3.8-3.81.51.0-3.80.30.4-0.2
Bone: stiffness0.91.52.7-1.5-1.61.31.5-1.61.61.7-1.3-1.30.80.3-1.40.50.4-0.2
Tibialis anterior weight0.20.61.70.40.3-0.6-0.00.20.0-0.51.30.10.80.71.01.31.2-1.2
Time to tail flick, vehicle, before self-admin0.50.61.1-0.6-0.60.80.9-0.81.00.8-1.00.21.00.5-0.00.80.9-0.8
Time to tail flick, vehicle, after self-admin0.20.41.20.60.8-0.7-0.40.6-0.6-0.50.51.00.1-0.00.90.10.3-1.1
Time to tail flick, test, before self-admin1.92.111.0-0.3-0.30.2-0.3-0.70.20.7-0.4-0.2-1.8-2.0-1.9-1.9-2.23.3
Time to tail flick, test, after self-admin0.60.61.2-0.8-0.90.90.8-1.11.00.6-0.2-0.50.70.7-0.40.90.7-0.6
Delta time to tail flick, vehicle, before/after SA0.20.20.80.20.3-0.3-0.10.3-0.3-0.40.60.30.30.50.60.50.5-0.9
Delta time to tail flick, test, before/after SA0.91.14.3-0.4-0.50.50.9-0.61.00.4-0.10.01.51.10.61.61.7-2.1
Tibia length1.64.47.9-2.7-2.62.62.4-2.62.32.8-2.7-2.30.70.4-2.7-0.0-0.00.2
Ambulatory time before self-admin0.31.02.9-0.2-0.30.30.0-0.10.10.8-1.6-1.0-0.8-1.4-1.3-1.7-1.41.2
Ambulatory time after self-admin1.01.64.1-0.9-0.90.90.3-0.60.11.0-1.5-2.0-1.1-1.1-1.9-1.8-1.71.5
Bone: tissue strength0.20.20.90.30.4-0.7-0.50.6-0.5-0.60.90.3-0.10.10.70.00.0-0.2
Total heroin consumption1.61.93.4-1.8-1.71.81.6-1.61.31.2-1.1-1.31.31.5-0.71.31.1-0.3
Bone: trabecular number0.81.44.1-0.9-0.70.41.1-0.50.70.30.3-0.81.61.90.51.81.8-2.0
Bone: trabecular spacing0.10.10.50.70.3-0.3-0.40.4-0.3-0.4-0.10.40.0-0.10.2-0.1-0.0-0.5
Bone: trabecular thickness4.46.09.6-3.0-2.82.93.1-2.82.52.4-1.9-2.02.62.6-1.32.42.3-1.3
Bone: trabecular tissue density0.30.51.7-0.5-0.70.40.3-0.90.81.0-0.9-0.2-0.2-0.9-1.3-0.6-0.61.0
Water consumed over 24 hours0.40.82.0-1.1-1.11.00.7-0.90.71.1-1.1-1.0-0.0-0.2-1.4-0.6-0.5-0.1
Number of responses in last shaping day0.10.10.7-0.1-0.00.1-0.1-0.40.20.20.20.2-0.5-0.4-0.2-0.2-0.50.8