Hub : Genes

Casp7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Casp7 0.14 0.09 9.0e-10 0.08 0.08 0.08 0.08 1.3e-09 2.7e-09 3.6e-09 1.1e-09
2 pVTA mRNA stability Casp7 0.37 0.13 2.8e-16 0.29 0.31 0.27 0.3 5.8e-13 4.4e-14 2.8e-12 1.1e-13
3 PL gene expression Casp7 0.12 0.06 6.1e-16 0.14 0.14 0.15 0.15 1.1e-14 4.3e-15 5.3e-16 8.1e-16
4 Brain gene expression Casp7 0.11 0.06 5.9e-14 0.11 0.16 0.15 0.15 1.7e-10 7.6e-15 1.1e-13 1.0e-13
5 Eye gene expression Casp7 0.56 0.2 7.9e-04 0.19 0.18 0.09 0.14 7.3e-04 1.1e-03 1.6e-02 3.3e-03
6 LHb gene expression Casp7 0.14 0.1 4.6e-03 0.11 0.06 0.06 0.11 1.3e-03 1.9e-02 1.6e-02 1.5e-03
7 Adipose gene expression Casp7 0.18 0.08 2.3e-13 0.1 0 0.1 0.02 5.4e-11 2.4e-01 1.8e-11 9.3e-04
8 Brain mRNA stability Casp7 0.13 0.08 3.0e-07 0.03 0.06 0.07 0.06 6.8e-04 1.3e-06 7.6e-07 1.5e-06
9 Adipose mRNA stability Casp7 0.13 0.08 3.6e-04 0.02 0 0.03 0.01 1.1e-03 1.5e-01 4.9e-04 2.3e-02
10 pVTA gene expression Casp7 0.29 0.11 1.6e-13 0.27 0.27 0.28 0.28 3.3e-12 4.0e-12 2.0e-12 1.5e-12
11 NAcc mRNA stability Casp7 0.08 0.05 2.3e-06 0.03 0.04 0.05 0.03 1.7e-04 6.6e-06 1.6e-06 6.6e-05
12 PL mRNA stability Casp7 0.13 0.06 8.5e-10 0.09 0.1 0.09 0.09 1.1e-09 1.4e-10 3.4e-10 5.9e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.72.95.71.8-1.8-1.61.3-0.9-0.8-1.4-2.2-2.20.3-2.42.2
Area under the delay curve0.70.81.71.0-1.0-1.10.5-1.3-0.9-0.4-0.9-0.80.2-0.80.8
BMI with tail7.825.439.36.3-5.9-5.85.9-5.1-4.8-5.4-4.3-5.04.5-3.52.8
BMI without tail3.67.411.23.4-3.2-3.33.1-2.9-2.1-3.0-2.2-2.72.2-2.01.7
Body weight9.238.562.07.9-6.9-7.27.1-6.2-5.8-7.0-5.4-6.45.5-4.33.3
Weight adjusted by age5.56.210.73.0-3.3-2.93.1-2.8-2.7-2.4-1.8-2.12.5-1.11.0
Bone surface0.71.22.01.4-1.2-1.11.0-0.5-0.4-1.1-1.3-1.40.6-1.41.2
Bone volume2.44.16.52.6-2.4-2.22.0-1.3-1.3-1.8-2.3-2.31.2-2.32.0
Breakpoint value in progressive ratio session0.20.30.80.6-0.0-0.5-0.4-0.40.20.2-0.7-0.7-0.3-0.90.5
Number of licking bursts0.91.12.61.0-0.8-1.10.4-1.3-0.7-1.1-1.2-1.6-0.0-1.31.0
Context. condit. distance diff. score0.70.82.2-0.51.51.0-0.80.81.3-0.41.1-0.1-0.30.8-1.0
Locomotion velocity, session 10.70.71.9-1.40.50.9-0.90.50.41.20.71.2-0.90.7-0.3
Locomotion distance, session 10.70.92.5-0.5-0.20.80.30.50.11.01.21.50.71.6-1.2
Locomotion velocity, session 20.80.93.0-0.30.20.70.30.20.10.31.41.01.11.7-1.6
Locomotion distance, session 20.91.33.71.1-1.6-1.21.5-0.9-1.20.10.20.71.90.8-1.0
Locomotion velocity, session 30.40.51.40.2-0.30.30.50.0-0.10.40.90.81.11.2-1.2
Locomotion distance, session 30.70.82.60.2-0.10.20.6-0.1-0.1-0.01.10.81.31.5-1.6
Stereotopy head waving bouts, day 30.10.10.5-0.1-0.3-0.40.2-0.6-0.7-0.2-0.5-0.1-0.1-0.20.3
Stereotopy head waving duration, day 30.30.31.3-0.80.30.3-0.6-0.5-0.2-0.1-0.4-0.3-1.1-0.40.8
Locomotion velocity, session 70.30.30.70.6-0.4-0.40.3-0.5-0.2-0.8-0.5-0.80.4-0.50.4
Locomotion distance, session 70.10.10.40.00.40.1-0.1-0.00.5-0.70.4-0.20.30.3-0.4
Stereotopy head waving bouts, day 70.20.20.50.3-0.2-0.50.0-0.5-0.4-0.4-0.5-0.70.1-0.50.3
Stereotopy head waving duration, day 70.80.91.50.9-1.0-1.10.7-1.0-1.2-0.6-1.2-1.00.4-1.11.0
Locomotion velocity, session 82.02.44.7-1.42.01.9-1.52.02.20.91.70.9-1.11.0-1.1
Locomotion distance, session 80.81.23.4-0.41.00.9-0.40.91.30.31.70.90.41.5-1.8
Degree of sensitization distance0.70.72.0-0.60.90.2-1.20.40.9-0.1-0.5-0.6-1.4-1.00.9
Degree of sensitization stereotypy0.10.10.40.3-0.2-0.4-0.0-0.1-0.1-0.2-0.5-0.6-0.0-0.60.4
Conditioned locomotion0.10.10.2-0.40.30.3-0.3-0.10.10.10.40.3-0.10.5-0.4
Cocaine response after cond. corrected3.23.67.1-1.91.41.8-1.11.61.42.12.42.7-0.22.6-2.3
Cocaine response after cond. not corrected3.13.45.0-2.11.82.0-1.51.51.61.82.22.2-0.72.2-1.9
Cocaine response before conditioning0.60.71.9-0.00.60.1-0.7-0.30.2-0.9-0.9-1.4-1.0-1.31.3
Saline control response0.20.30.7-0.10.00.5-0.00.4-0.20.80.50.90.40.7-0.6
Bone: connectivity density0.20.31.00.10.10.1-0.20.20.5-0.6-0.5-1.0-0.6-0.91.0
Bone: cortical apparent density1.31.65.9-0.60.61.00.2-0.10.1-0.11.91.01.42.4-2.3
Bone: cortical area9.213.921.04.4-4.6-4.34.1-3.7-4.0-3.3-3.7-3.33.1-3.02.6
Bone: cortical porosity0.20.20.70.4-0.4-0.3-0.00.20.10.4-0.7-0.2-0.2-0.80.6
Bone: cortical porosity0.40.41.50.7-0.5-0.60.10.10.10.1-0.9-0.6-0.1-1.20.9
Bone: cortical thickness4.77.811.43.3-3.4-3.13.3-3.0-3.2-2.7-2.4-2.32.8-1.81.4
Bone: cortical thickness2.12.54.72.2-1.7-1.82.0-1.6-1.7-1.6-0.9-1.12.0-0.60.1
Bone: cortical tissue density1.41.86.4-0.80.81.20.00.10.3-0.02.11.11.22.5-2.4
Condit. Reinf. active minus inactive responses0.20.21.0-0.4-0.10.30.00.4-0.00.90.41.00.10.6-0.5
Condit. Reinf. active-inactive response ratio0.30.31.0-0.50.10.7-0.20.90.51.00.30.7-0.40.2-0.1
Condit. Reinf. active responses0.30.41.40.2-1.2-0.60.8-0.5-1.10.4-0.50.50.5-0.20.4
Condit. Reinf. inactive responses0.91.13.00.5-1.6-1.21.0-1.2-1.7-0.1-1.2-0.10.4-0.81.2
Incentive salience index mean0.70.92.9-0.90.10.8-0.31.00.31.70.91.7-0.11.0-0.8
Condit. Reinf. lever presses0.60.82.9-0.9-0.00.9-0.31.00.21.70.61.5-0.20.8-0.5
Condit. Reinf. active minus inactive responses1.72.06.70.3-1.7-1.10.6-1.2-1.40.1-2.1-0.8-0.9-2.12.6
Condit. Reinf. active-inactive response ratio0.50.52.2-0.4-0.7-0.2-0.1-0.1-0.20.7-0.9-0.0-1.0-1.01.5
Condit. Reinf. active responses3.24.410.21.3-2.4-1.91.3-1.9-2.4-0.7-3.1-1.6-0.4-2.83.2
Condit. Reinf. inactive responses2.12.65.21.4-1.6-1.61.1-1.4-2.0-1.2-2.3-1.50.3-2.01.9
Condit. Reinf. lever presses0.70.91.90.7-1.1-1.10.4-0.8-0.9-0.1-1.4-0.6-0.3-1.41.4
Condit. Reinf. lever reinforcers received2.13.07.40.9-2.1-1.61.0-1.4-2.0-0.2-2.6-1.0-0.5-2.42.7
Conditioned reinforcement - actives1.11.13.1-0.4-0.10.4-0.20.2-0.01.71.11.70.71.5-1.7
Conditioned reinforcement - inactives0.70.81.70.9-1.0-1.00.8-1.3-1.2-0.6-0.9-0.70.7-0.40.1
Conditioned locomotion1.21.43.5-0.60.20.8-0.40.50.51.71.41.80.61.7-1.9
Patch foraging indifference point 0 sec4.16.68.72.7-2.7-2.92.4-2.9-3.0-2.7-2.7-2.91.3-2.22.1
Patch foraging indifference point AUC0.40.51.30.2-0.9-0.4-0.1-0.2-0.40.9-0.90.1-0.5-1.11.1
Delay disc. indifference point, 0s delay0.91.02.91.0-0.8-1.40.7-1.7-1.2-1.3-0.6-1.00.8-0.2-0.1
Delay disc. indifference point, 16s delay0.10.10.70.3-0.1-0.0-0.4-0.10.10.8-0.1-0.0-0.4-0.40.4
Delay disc. indifference point, 2s delay0.20.20.60.30.3-0.3-0.2-0.70.4-0.80.2-0.50.10.1-0.4
Delay disc. indifference point, 24s delay1.01.02.40.9-0.7-0.90.0-0.9-0.5-0.0-1.3-1.4-0.5-1.51.5
Delay disc. indifference point, 4s delay0.10.10.3-0.10.40.1-0.50.10.50.40.20.1-0.5-0.1-0.0
Delay disc. indifference point, 8s delay3.23.36.71.9-2.6-2.11.8-2.2-2.5-0.8-1.8-1.21.0-1.31.5
Indifference point function ln k0.10.21.2-0.10.20.10.4-0.3-0.1-1.10.2-0.50.30.5-0.2
Indifference point function log k0.10.21.2-0.10.20.10.4-0.3-0.1-1.10.2-0.50.30.5-0.2
Patch foraging total patch changes 0 sec4.16.68.52.7-2.7-2.92.3-2.9-2.9-2.5-2.8-2.91.1-2.42.3
Patch foraging total patch changes 12 sec1.41.83.71.3-1.3-1.40.6-1.3-1.1-0.9-1.7-1.7-0.2-1.91.7
Patch foraging total patch changes 18 sec2.83.66.11.7-2.4-2.11.3-1.9-2.1-0.7-2.5-1.70.1-2.42.3
Patch foraging total patch changes 24 sec2.32.96.31.5-1.9-1.70.8-1.6-1.7-0.5-2.3-1.7-0.1-2.52.2
Patch foraging total patch changes 6 sec4.87.110.32.9-3.2-3.02.4-2.6-3.0-2.0-3.1-2.51.2-2.72.5
Patch foraging time to switch 0 sec0.30.51.1-0.51.00.8-0.80.50.9-0.00.80.2-0.10.7-0.9
Patch foraging water rate 0 sec0.50.81.40.7-1.1-1.01.1-1.0-1.2-0.7-0.9-0.70.4-0.80.9
Patch foraging water rate 12 sec1.42.15.11.0-1.2-1.21.0-0.9-1.4-1.3-1.9-1.7-0.2-2.02.3
Patch foraging water rate 18 sec0.40.61.41.0-1.1-0.91.2-0.6-0.8-0.5-0.3-0.11.1-0.10.0
Patch foraging water rate 24 sec1.01.32.81.5-1.5-1.61.7-1.1-1.2-0.8-0.5-0.51.5-0.1-0.1
Patch foraging water rate 6 sec0.40.51.10.5-0.7-0.71.1-1.1-0.9-0.90.0-0.31.00.3-0.2
Seeking ratio, delayed vs. immediate footshock0.30.31.2-0.20.50.4-0.50.50.60.30.80.40.20.8-1.1
Distance traveled before self-admin0.40.41.2-0.40.90.40.00.30.1-0.70.90.30.31.0-1.1
Distance traveled after self-admin0.70.83.20.9-0.2-0.20.8-0.3-0.2-0.31.00.11.51.3-1.8
Extensor digitorum longus weight0.51.94.01.6-1.2-1.21.0-0.8-0.7-1.4-1.7-2.00.4-1.91.7
Bone: elastic displacement0.10.10.2-0.10.30.1-0.30.50.20.5-0.10.2-0.5-0.30.2
Bone: elastic work0.70.93.01.4-1.2-1.01.5-0.3-1.0-0.4-0.20.31.70.1-0.4
Bone: endosteal estimation1.43.15.52.3-2.2-2.31.9-1.7-1.5-1.4-1.7-1.41.4-1.61.2
Bone: endosteal perimeter4.28.714.53.8-3.8-3.53.6-2.8-3.3-2.3-2.7-2.02.8-2.11.7
Epididymis fat weight14.934.751.77.2-6.5-7.06.1-6.5-5.9-6.4-5.4-5.94.7-4.53.4
Delta time in closed arm before/after self-admin0.20.20.8-0.30.30.1-0.0-0.1-0.10.10.50.50.40.8-0.9
Delta time in open arm before/after self-admin0.30.30.70.5-0.6-0.40.1-0.4-0.20.5-0.7-0.5-0.2-0.80.8
Diff in mean of infusions in LGA sessions2.32.55.1-2.02.31.8-2.21.91.91.00.80.6-1.90.10.1
Delay discount exponential model param0.80.81.7-1.11.01.2-0.51.30.90.30.90.8-0.20.9-0.8
Extinction: sum of active levers before priming0.40.41.2-0.50.70.4-1.10.31.01.10.20.3-0.9-0.10.0
Active lever presses in extinction session 60.30.30.90.9-0.5-0.70.4-0.8-0.5-0.2-0.4-0.60.4-0.30.0
Bone: final force2.43.87.72.6-2.8-2.22.6-1.7-2.0-1.3-1.5-1.22.4-1.10.8
Bone: final moment2.64.28.32.8-2.9-2.42.7-1.8-2.0-1.4-1.7-1.32.5-1.30.9
Food consumed during 24 hour testing period0.10.10.2-0.20.40.10.10.40.3-0.20.40.1-0.10.3-0.3
Glucose6.09.115.63.4-2.8-3.33.1-3.5-3.4-4.0-2.7-3.12.5-2.01.7
Heart weight2.83.95.92.2-2.4-2.42.3-2.4-2.2-2.1-1.6-1.61.9-1.00.8
Delay discount hyperbolic model param0.50.51.2-0.90.81.0-0.41.10.70.40.70.7-0.20.7-0.6
Intermittent access intake day 1-15 change4.14.08.11.8-1.8-2.11.8-2.8-2.4-2.6-1.9-2.41.2-1.41.1
Intermittent access intake escalation4.44.38.32.2-2.2-2.42.4-2.9-2.5-2.5-1.4-1.82.1-0.60.2
Intermittent access intake escalation 22.12.13.51.6-1.4-1.71.7-1.9-1.8-1.7-0.6-0.91.80.1-0.4
Intermitt. access day 1 inactive lever presses2.32.44.71.7-1.4-1.71.1-1.5-1.2-1.6-1.8-2.20.4-1.81.6
Intermitt. access day 15 inactive lever presses0.10.10.30.4-0.5-0.40.4-0.5-0.5-0.2-0.3-0.30.3-0.10.1
Intermitt. access escalation Index0.10.10.20.40.2-0.20.3-0.00.1-0.2-0.1-0.30.30.2-0.4
Intermittent access day 1 total infusions0.30.32.50.4-0.6-0.2-0.1-0.1-0.11.60.10.80.40.2-0.6
Intermittent access day 15 total infusions1.41.53.71.6-1.5-1.51.2-1.9-1.5-0.4-0.8-0.71.5-0.3-0.3
Intermittent access terminal intake (last 3 days)0.70.72.21.0-1.0-1.00.7-1.5-1.0-0.2-0.5-0.41.1-0.1-0.4
Intermittent access total infusions0.70.82.11.0-1.4-1.00.8-1.3-1.20.5-0.50.01.1-0.0-0.4
Intermittent access day 1 locomotion0.70.82.40.0-0.00.4-0.10.30.41.51.01.20.81.1-1.4
Intermittent access day 15 total locomotion2.52.74.01.8-2.0-1.81.7-2.0-2.0-1.4-1.5-1.51.3-1.10.9
Intermittent access total locomotion0.50.62.00.5-0.8-0.30.8-0.6-0.60.30.40.61.40.9-1.1
Intermittent access standard deviation1.31.42.61.2-1.2-1.50.5-1.5-1.3-0.5-1.6-1.30.1-1.51.1
Left kidney weight2.77.725.33.6-2.9-2.93.9-2.3-2.3-2.2-0.0-0.65.01.2-2.2
Right kidney weight4.412.329.24.6-4.2-3.94.8-3.4-3.5-3.4-1.3-1.95.40.0-0.8
Cocaine induced anxiety5.05.89.2-2.53.02.8-2.22.72.71.72.72.2-1.12.3-2.3
Post-drug Anxiety1.31.52.5-1.01.31.2-0.81.61.11.21.51.4-0.21.3-1.4
Baseline Anxiety5.96.210.22.9-3.2-3.02.5-2.5-2.8-1.5-2.7-2.21.4-2.42.2
Tail length0.51.43.31.3-0.8-1.60.6-1.8-1.0-1.6-1.0-1.50.4-1.00.7
Length with tail2.59.115.23.9-3.2-3.63.2-3.3-2.9-3.5-2.5-3.12.8-1.81.1
Length without tail5.211.317.74.2-3.7-3.73.9-3.6-3.6-3.7-2.8-3.33.3-2.01.4
Times rat made contact with spout0.40.41.30.8-0.9-0.81.0-0.4-0.70.2-0.10.31.10.2-0.5
Lifetime Intake0.80.92.41.1-1.6-1.10.9-1.3-1.30.7-0.50.21.20.1-0.5
Liver weight, left4.16.69.63.0-3.0-3.12.5-2.9-2.4-2.2-2.7-2.61.6-2.41.9
Liver weight, right7.011.618.64.3-4.0-4.23.9-3.5-3.4-3.3-3.0-2.93.2-2.31.7
Locomotor activity1.62.64.52.0-1.5-1.71.8-1.9-1.7-2.1-1.1-1.61.9-0.50.3
Locomotor testing distance1.93.15.52.0-1.7-1.82.2-2.2-2.1-2.3-0.7-1.22.40.2-0.4
Locomotor testing rearing1.32.03.71.8-1.1-1.31.6-1.8-1.6-1.9-0.7-1.41.7-0.2-0.1
Locomotion in novel chamber0.50.72.40.10.10.30.40.50.40.41.20.91.01.3-1.5
Locomotion in novel chamber post-restriction1.82.24.3-1.40.81.4-0.71.11.21.61.92.10.12.1-1.8
Fecal boli incidents, locomotor time 11.01.12.80.3-1.1-0.80.6-1.2-1.6-0.9-1.3-0.8-0.3-1.11.7
Change in fecal boli incidents, locomotor task1.51.43.5-0.91.41.3-1.11.71.91.21.10.5-0.70.6-0.9
Time >=10cm from walls, locomotor time 11.71.73.2-1.71.61.4-1.41.61.81.01.01.1-1.30.5-0.5
Bouts of movement, locomotor time 10.80.91.70.9-1.2-1.20.5-0.7-0.70.0-1.2-1.0-0.0-1.31.1
Total resting periods, locomotor time 10.50.61.40.9-1.2-1.00.5-0.5-0.40.3-0.9-0.70.2-1.00.8
Rest time, locomotor task time 10.40.41.00.3-0.7-0.20.60.0-0.30.90.51.00.90.8-0.8
Distance moved, locomotor task time 10.20.20.70.20.2-0.1-0.0-0.10.3-0.5-0.5-0.8-0.3-0.70.6
Vertical activity count, locomotor time 10.40.41.5-0.61.21.0-0.40.50.8-0.40.6-0.0-0.30.3-0.4
Time >=10cm from walls, locomotor time 20.60.62.00.4-0.1-0.70.0-0.80.1-1.0-1.0-1.4-0.3-1.20.8
Bouts of movement, locomotor time 22.02.14.3-1.11.81.7-1.62.02.11.61.40.9-0.80.9-1.1
Total resting periods, locomotor time 21.31.42.8-0.71.31.3-1.21.61.71.51.20.9-0.50.8-1.0
Rest time, locomotor task time 20.10.10.30.4-0.2-0.00.5-0.3-0.5-0.30.2-0.10.60.4-0.3
Distance moved, locomotor task time 20.30.30.90.2-0.6-0.60.1-0.4-0.10.3-0.8-0.4-0.3-1.00.9
Vertical activity count, locomotor time 20.40.50.80.3-0.4-0.60.3-0.9-0.7-0.9-0.8-0.8-0.1-0.90.8
Light reinforcement 11.42.63.9-1.71.81.6-1.71.82.01.81.61.5-1.11.2-1.2
Light reinforcement 22.33.15.3-1.71.91.7-1.81.82.31.72.01.6-0.81.6-1.7
Bone: marrow area1.53.25.72.4-2.2-2.32.0-1.8-1.6-1.5-1.8-1.41.4-1.61.2
Bone: maximum diameter8.215.021.34.6-4.6-4.54.0-3.7-4.1-3.4-4.1-3.62.7-3.63.1
Bone: maximum force2.33.97.42.7-2.7-2.22.6-1.6-2.0-1.3-1.6-1.12.5-1.20.8
Bone: maximum moment2.44.28.02.8-2.8-2.42.7-1.7-2.0-1.3-1.7-1.22.5-1.30.9
Mean time between licks in bursts0.10.20.4-0.0-0.1-0.3-0.2-0.30.0-0.3-0.5-0.6-0.5-0.60.7
Mean num. licks in bursts0.70.92.4-0.0-0.20.20.70.6-0.20.81.01.51.21.4-1.4
Cd content in liver3.13.45.5-2.11.82.1-2.02.32.22.31.31.8-1.90.8-0.5
Co content in liver0.40.50.9-0.80.50.9-0.20.90.70.40.80.80.00.9-0.5
Cu content in liver0.10.10.20.2-0.40.20.50.30.20.10.30.30.50.3-0.2
Fe content in liver0.00.00.1-0.3-0.1-0.1-0.1-0.0-0.20.2-0.10.1-0.4-0.00.3
K content in liver0.50.51.1-0.50.80.9-0.90.91.10.90.50.2-0.80.1-0.1
Mg content in liver0.30.30.8-0.10.20.4-0.60.50.80.9-0.1-0.2-0.8-0.60.5
Mn content in liver0.60.71.8-0.61.31.1-1.10.71.20.30.90.1-0.50.6-0.8
Na content in liver0.40.51.3-0.50.80.7-1.10.60.50.6-0.2-0.3-1.1-0.50.6
Rb content in liver1.21.53.7-1.61.51.1-1.90.91.01.70.40.7-1.90.00.1
Se content in liver0.20.20.6-0.40.50.7-0.60.60.50.30.1-0.1-0.7-0.20.5
Sr content in liver3.22.94.8-1.51.71.8-1.41.92.01.42.21.5-0.62.0-1.9
Zn content in liver2.83.15.8-1.51.92.3-1.52.22.41.32.11.1-0.71.7-1.5
Bone: minimum diameter3.87.110.63.1-3.0-3.32.7-2.9-2.5-2.8-2.6-2.61.9-2.32.0
Time in familiar zone, hab. session 10.20.20.9-0.40.30.7-0.00.90.40.20.30.40.10.4-0.1
Time in novel zone, hab. session 11.01.02.21.0-0.8-1.30.5-1.5-0.9-0.9-1.1-1.20.1-1.10.9
Total zone transitions, hab. session 11.21.73.51.4-1.6-1.61.7-1.7-1.6-1.1-0.5-0.41.90.2-0.4
Total locomotion distance, hab. session 10.10.20.9-0.0-0.0-0.70.1-0.9-0.5-0.40.00.10.20.3-0.4
Locomotion velocity, hab. session 10.10.20.5-0.30.2-0.4-0.1-0.4-0.20.20.30.60.00.6-0.7
Time in familiar zone, hab. session 21.31.43.50.8-1.4-1.30.80.1-0.80.1-1.9-0.5-0.3-1.91.8
Time in novel zone, hab. session 20.70.72.3-0.30.50.7-0.1-0.50.1-0.31.30.40.81.5-1.4
Total zone transitions, hab. session 21.31.73.91.5-1.8-1.41.7-1.6-1.5-1.0-0.5-0.52.00.1-0.3
Total locomotion distance, hab. session 20.60.81.90.8-1.0-1.21.0-1.4-0.9-0.9-0.0-0.21.20.4-0.6
Locomotion velocity, hab. session 20.40.61.40.6-0.7-1.00.8-1.2-0.7-0.80.1-0.11.00.5-0.7
Novel to familiar place preference ratio0.30.41.10.2-0.0-0.2-0.2-0.8-0.2-0.6-0.7-1.1-0.4-0.80.9
Novelty place preference0.50.51.50.4-0.2-0.4-0.0-1.1-0.4-0.8-0.8-1.2-0.2-0.90.8
Time in novel zone, NPP test1.11.12.70.8-0.6-0.80.2-1.4-0.7-1.1-1.3-1.6-0.2-1.41.3
Total zone transitions, NPP test0.60.92.21.3-1.3-1.21.2-1.0-0.7-0.6-0.1-0.21.50.1-0.6
Total locomotion distance, NPP test0.30.51.10.7-0.7-1.10.7-1.0-0.4-0.60.1-0.10.90.2-0.7
Locomotion velocity, NPP test0.30.41.60.3-0.2-0.50.4-0.50.0-0.30.70.40.80.8-1.2
Intraocular pressure3.85.29.12.0-3.0-2.62.2-2.5-2.8-1.6-2.7-1.90.9-2.22.2
Delta distance traveled before/after self-admin0.80.82.81.6-1.1-0.81.1-0.8-0.2-0.00.1-0.51.70.2-0.8
Delta ambulatory time before/after self-admin0.60.72.41.5-1.2-0.90.8-0.8-0.30.1-0.4-0.81.1-0.4-0.2
Parametrial fat weight8.616.824.54.5-4.5-5.03.8-4.2-4.0-3.7-4.6-4.22.0-4.13.8
Pavlov. Cond. lever latency0.30.41.10.4-0.2-0.50.0-0.4-0.2-0.4-0.8-0.7-0.5-1.00.9
Pavlov. Cond. magazine entry latency0.20.30.80.6-0.5-0.80.6-0.6-0.7-0.3-0.3-0.10.90.2-0.4
Pavlov. Cond. change in total contacts0.10.10.30.10.00.10.30.20.0-0.30.2-0.20.50.4-0.4
Pavlov. Cond. index score0.20.30.90.6-0.5-0.50.7-0.3-0.5-0.4-0.1-0.20.90.2-0.3
Pavlov. Cond. latency score0.10.20.70.4-0.4-0.30.6-0.2-0.4-0.30.0-0.00.80.3-0.4
Pavlov. Cond. lever contacts0.10.10.2-0.3-0.00.30.00.50.00.50.30.50.20.4-0.2
Pavlov. Cond. magazine entry number1.01.22.0-1.21.21.3-1.41.31.41.20.70.7-1.40.20.0
Pavlov. Cond. intertrial magazine entries0.00.10.3-0.1-0.5-0.10.3-0.3-0.30.10.00.10.20.20.1
Pavlov. Cond. lever-magazine prob. diff.0.10.20.60.5-0.4-0.50.6-0.2-0.5-0.3-0.2-0.20.80.1-0.2
Pavlov. Cond. response bias0.30.31.10.6-0.6-0.50.8-0.5-0.8-0.4-0.0-0.01.10.4-0.5
Pavlov. Cond. lever latency0.50.61.6-0.30.90.70.00.50.6-0.61.20.20.61.3-1.3
Pavlov. Cond. magazine entry latency1.21.42.61.6-1.2-1.60.9-1.2-1.2-0.9-1.3-1.20.7-1.20.8
Pavlov. Cond. change in total contacts1.01.42.81.0-1.5-1.30.6-1.1-1.30.2-1.7-0.6-0.2-1.61.5
Pavlov. Cond. index score1.31.62.91.5-1.7-1.61.0-1.3-1.4-0.3-1.6-0.90.5-1.41.2
Pavlov. Cond. latency score1.31.62.61.5-1.6-1.60.9-1.3-1.3-0.5-1.6-1.00.5-1.41.2
Pavlov. Cond. lever contacts0.50.71.20.9-1.0-1.10.4-1.0-1.0-0.1-1.1-0.50.1-1.00.8
Pavlov. Cond. magazine entry number0.91.12.4-1.51.21.4-0.90.91.10.51.21.0-0.71.1-0.8
Pavlov. Cond. intertrial magazine entries0.20.30.90.4-0.1-0.20.3-0.6-0.2-0.9-0.4-0.90.0-0.50.5
Pavlov. Cond. lever-magazine prob. diff.1.21.52.91.5-1.7-1.61.0-1.3-1.5-0.3-1.5-0.80.6-1.21.0
Pavlov. Cond. response bias1.01.32.41.3-1.4-1.50.8-1.2-1.4-0.2-1.5-0.70.3-1.31.1
Time in closed arm before self-admin0.20.20.80.70.0-0.10.40.20.5-0.90.1-0.70.2-0.3-0.1
Time in closed arm after self-admin0.40.41.2-0.20.70.6-0.40.50.90.30.80.40.20.7-1.1
Time in open arm before self-admin1.11.22.5-1.41.61.2-1.61.00.80.90.81.0-1.20.6-0.4
Time in open arm after self-admin0.50.62.4-0.80.40.5-1.00.50.21.5-0.10.6-1.2-0.30.5
Bone: periosteal estimation5.411.117.44.2-4.1-4.03.8-3.3-3.3-2.9-3.2-2.82.9-2.72.1
Bone: periosteal perimeter9.415.725.74.9-5.1-4.64.6-3.9-4.3-3.3-3.8-3.13.5-3.02.6
Bone: post-yield work0.10.10.40.3-0.1-0.2-0.2-0.00.30.2-0.3-0.3-0.3-0.60.3
Progressive ratio test 1 active lever presses1.01.02.21.0-1.4-0.91.0-1.2-1.30.7-0.00.51.50.6-1.0
Progressive ratio test 1 breakpoint0.50.51.10.5-1.0-0.60.5-1.0-0.90.8-0.00.51.00.4-0.7
Progressive ratio test 1 inactive lever presses0.20.20.60.7-0.5-0.60.4-0.8-0.70.1-0.3-0.10.5-0.0-0.3
Progressive ratio test 2 active lever presses2.02.24.51.9-2.1-1.71.7-1.9-2.0-0.3-0.8-0.42.0-0.1-0.4
Progressive ratio test 2 breakpoint1.82.04.31.8-2.1-1.61.6-1.8-1.9-0.2-0.9-0.41.8-0.2-0.3
Progressive ratio test 2 inactive lever presses1.11.32.11.3-1.3-1.31.0-1.2-1.4-0.7-1.5-1.20.8-1.10.8
Incentive Sensitization - Responses1.61.62.41.5-1.5-1.41.3-1.6-1.6-1.0-1.2-1.11.2-0.80.5
Incentive Sensitization - Breakpoint1.71.72.61.5-1.6-1.41.3-1.6-1.6-1.1-1.3-1.21.1-0.90.7
Sum of active levers in priming session hrs 5-61.91.83.6-1.81.61.4-1.71.41.91.30.91.0-1.40.3-0.2
Progressive ratio0.80.92.4-1.10.80.8-1.11.00.51.50.51.4-0.90.5-0.3
Food seeking constrained by brief footshock0.60.71.6-0.40.70.6-1.11.20.91.3-0.30.3-1.3-0.70.6
Seeking ratio, punishment vs. effort0.20.31.10.8-0.2-0.30.3-0.30.1-0.7-0.4-1.10.3-0.60.2
Retroperitoneal fat weight12.842.160.87.8-7.1-7.77.0-7.1-6.4-7.2-5.9-6.75.2-4.73.7
Reaction time number correct1.01.42.51.2-1.1-1.20.9-1.4-1.1-1.4-1.3-1.60.3-1.21.1
Reaction time mean minus median0.40.51.50.6-1.2-0.80.9-0.7-0.70.4-0.40.50.90.1-0.1
Reaction time mean minus median AUC0.60.72.30.9-1.1-0.91.2-1.0-0.7-0.20.10.31.50.5-0.8
Reaction time num false alarms0.00.10.3-0.1-0.0-0.1-0.20.00.5-0.00.30.1-0.00.3-0.3
Reaction time num false alarms AUC0.10.10.30.1-0.1-0.30.0-0.40.2-0.30.40.10.30.5-0.5
Reaction time trials correct on left1.01.42.51.2-1.1-1.20.9-1.4-1.1-1.4-1.3-1.60.3-1.21.1
Reaction time trials on left1.01.52.51.2-1.2-1.21.0-1.4-1.1-1.4-1.3-1.60.4-1.31.1
Reaction time mean0.30.41.00.4-0.7-0.60.8-0.6-1.0-0.2-0.30.40.90.2-0.0
Reaction time mean AUC0.10.10.30.0-0.3-0.20.3-0.2-0.60.2-0.10.60.50.3-0.1
Median of all reaction times0.20.31.00.3-0.4-0.40.7-0.5-1.0-0.4-0.10.40.90.3-0.2
Reaction time omissions0.20.30.60.6-0.8-0.60.6-0.30.0-0.2-0.6-0.50.6-0.60.4
Reaction time false alarm rate0.30.40.7-0.50.50.4-0.60.40.80.50.80.8-0.10.8-0.8
Reaction time premature initiation rate0.70.92.90.9-0.7-0.61.0-1.1-1.2-0.60.20.11.70.8-1.1
Reaction time premature initiations1.52.04.31.6-1.5-1.41.7-2.0-1.9-1.4-0.5-0.82.10.2-0.5
Std. dev. reaction times1.31.84.11.4-2.0-1.71.8-1.5-1.8-0.4-1.1-0.11.7-0.40.4
Reaction time trials completed1.01.52.51.2-1.2-1.21.0-1.4-1.1-1.4-1.3-1.60.4-1.31.1
Reaction time trials AUC1.11.62.51.2-1.2-1.31.0-1.4-1.2-1.4-1.4-1.60.4-1.31.2
Run reversals in cocaine runway, females0.60.61.41.0-1.0-0.61.1-0.4-0.8-0.8-0.2-0.41.2-0.1-0.1
Run reversals in cocaine runway, males1.41.43.0-1.21.71.4-1.71.41.60.80.80.4-1.30.3-0.4
Latency to leave start box in cocaine runway0.80.81.5-0.81.01.0-0.81.11.21.01.00.9-0.60.7-0.5
Latency to leave start box in cocaine runway, F1.01.12.1-1.11.31.2-0.91.21.40.51.20.9-0.70.9-0.6
Latency to leave start box in cocaine runway, M0.20.20.50.6-0.6-0.30.2-0.4-0.40.7-0.10.10.60.0-0.2
Std. dev. time between licks in bursts0.30.41.4-0.90.20.2-0.80.30.61.20.20.7-0.80.1-0.1
Total sessions with >9 infusions3.94.38.82.3-2.9-2.32.7-2.5-3.0-0.9-0.8-0.42.90.2-0.6
Short access day 1 total inactive lever presses0.40.51.71.3-0.7-0.90.8-0.7-0.7-0.2-0.5-0.60.7-0.5-0.2
Short access day 10 total inactive lever presses0.80.91.40.8-0.9-1.00.8-1.0-0.9-1.2-1.1-1.10.3-0.81.0
Short access day 1 total infusions0.60.71.70.9-0.9-0.70.9-0.9-1.00.20.10.21.30.6-1.0
Short access day 10 total infusions0.50.62.10.2-0.6-0.20.2-0.1-0.51.40.41.30.70.8-1.1
Short access total infusions0.70.71.50.7-1.1-0.60.6-0.8-0.91.20.10.81.20.7-1.1
Short access day 1 locomotion0.50.61.20.6-1.1-0.60.7-0.8-1.00.9-0.00.60.90.4-0.6
Short access day 10 total locomotion0.70.71.80.9-0.6-0.81.2-0.9-0.9-1.30.1-0.61.20.4-0.5
Short access total locomotion1.11.13.60.7-0.9-0.51.0-0.7-0.80.50.80.91.91.4-1.7
One hour access (0.3 mA shock)1.92.33.71.8-1.7-1.91.0-1.9-1.7-0.6-1.9-1.50.6-1.51.0
Compulsive drug intake0.30.31.0-0.30.40.2-0.70.50.60.7-0.2-0.0-1.0-0.60.5
One hour access (shock baseline)1.61.93.61.6-1.8-1.71.5-1.8-1.9-0.7-1.1-0.81.6-0.30.0
Social response proportion2.12.27.42.1-1.7-1.32.2-1.2-1.2-1.2-0.0-0.32.70.6-1.0
Social responses4.45.610.02.9-3.2-2.92.7-2.6-2.6-1.8-2.1-1.72.2-1.61.2
Social time1.52.04.72.2-1.7-1.61.8-1.1-1.5-1.0-0.8-0.62.2-0.2-0.3
Soleus weight3.811.216.74.1-3.5-3.83.8-4.1-3.5-4.0-2.2-3.04.1-1.20.5
Bone: stiffness1.52.34.11.9-2.0-1.72.0-1.4-1.7-1.2-1.1-0.82.0-0.70.5
Tibialis anterior weight0.10.41.40.0-0.20.2-0.40.40.30.5-0.7-0.3-0.6-1.01.2
Time to tail flick, vehicle, before self-admin2.62.73.91.4-1.7-1.81.4-1.8-1.9-1.6-2.0-1.60.5-1.61.7
Time to tail flick, vehicle, after self-admin0.10.10.5-0.2-0.3-0.00.6-0.1-0.7-0.20.10.30.20.30.1
Time to tail flick, test, before self-admin1.51.44.90.9-1.0-0.51.4-0.7-0.8-0.10.90.82.21.5-1.8
Time to tail flick, test, after self-admin2.52.63.92.0-1.9-1.91.6-1.8-1.8-1.5-1.5-1.71.2-1.21.1
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.30.30.4-0.10.4-0.00.30.50.5-0.10.5-0.3
Delta time to tail flick, test, before/after SA2.82.64.81.2-1.4-1.51.0-1.5-1.6-1.6-2.1-2.0-0.1-2.02.2
Tibia length1.64.48.02.6-2.4-2.42.8-2.3-2.0-2.4-1.1-1.52.8-0.40.1
Ambulatory time before self-admin0.60.63.30.40.1-0.50.8-0.8-0.8-1.80.2-0.70.80.6-0.7
Ambulatory time after self-admin0.80.92.81.0-0.3-0.51.1-0.6-0.5-0.90.7-0.31.71.1-1.6
Bone: tissue strength0.30.31.1-0.40.50.5-0.60.90.61.00.10.5-0.7-0.20.2
Total heroin consumption0.91.01.91.1-1.0-1.40.5-1.0-0.9-0.6-1.3-1.20.0-1.31.1
Bone: trabecular number0.71.13.30.7-0.7-0.40.30.20.2-0.6-1.4-1.6-0.4-1.81.8
Bone: trabecular spacing0.10.10.2-0.20.40.1-0.4-0.0-0.30.5-0.00.2-0.4-0.00.1
Bone: trabecular thickness5.36.49.42.7-2.9-3.12.4-2.5-2.4-2.3-2.9-2.51.3-2.52.2
Bone: trabecular tissue density0.50.72.41.0-1.0-0.51.2-0.9-0.9-0.70.2-0.11.50.5-0.6
Water consumed over 24 hours0.40.51.60.9-0.5-0.61.0-0.4-0.6-0.50.2-0.01.30.6-0.8
Number of responses in last shaping day0.10.10.30.1-0.3-0.20.2-0.4-0.30.10.10.20.50.5-0.5