Hub : Genes

Casp7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Casp7 0.59 0.18 1.5e-03 0.11 0.08 0.03 0.02 1.0e-02 2.7e-02 1.2e-01 1.6e-01
2 NAcc gene expression Casp7 0.11 0.06 3.4e-15 0.1 0.1 0.1 0.1 4.9e-15 2.8e-14 1.4e-14 1.5e-14
3 PL gene expression Casp7 0.12 0.06 2.8e-16 0.14 0.14 0.13 0.14 1.2e-14 1.6e-14 1.9e-14 1.1e-14
4 LHb gene expression Casp7 0.14 0.1 5.9e-03 0 0.05 0.01 0.01 2.9e-01 2.6e-02 1.7e-01 1.4e-01
5 pVTA mRNA stability Casp7 0.28 0.11 0.0e+00 0.32 0.34 0.32 0.33 2.1e-26 7.0e-28 2.1e-26 5.2e-27
6 IC gene expression Casp7 0.07 0.05 3.6e-03 0.06 0.05 0.03 0.06 2.4e-03 3.3e-03 2.6e-02 1.9e-03
7 Brain gene expression Casp7 0.11 0.06 1.1e-12 0.12 0.14 0.13 0.12 1.0e-11 9.9e-13 8.5e-12 1.2e-11
8 Adipose gene expression Casp7 0.18 0.09 1.8e-12 0.09 -0 0.1 0.06 1.4e-10 3.8e-01 3.0e-11 1.4e-07
9 Adipose mRNA stability Casp7 0.14 0.08 1.2e-04 0.03 0 0.03 0.02 4.1e-04 9.8e-02 1.1e-04 6.2e-03
10 Brain mRNA stability Casp7 0.14 0.09 4.3e-07 0.06 0.07 0.07 0.07 3.2e-06 1.7e-07 1.8e-07 2.6e-07
11 NAcc mRNA stability Casp7 0.1 0.05 1.2e-11 0.07 0.08 0.07 0.08 3.0e-11 1.7e-12 2.4e-11 1.4e-11
12 pVTA gene expression Casp7 0.26 0.1 0.0e+00 0.31 0.3 0.29 0.31 4.0e-25 4.7e-24 2.5e-23 5.5e-25
13 LHb mRNA stability Casp7 0.2 0.13 5.8e-03 0.04 0.08 -0 0.02 4.6e-02 6.9e-03 3.9e-01 8.9e-02
14 PL mRNA stability Casp7 0.14 0.06 3.5e-10 0.09 0.1 0.09 0.09 2.4e-10 2.3e-11 3.5e-10 2.4e-10
15 NAcc intron excision ratio chr1_265449781_265472451 0.02 0.02 2.7e-03 0.01 0.01 0.01 0.01 3.7e-03 3.4e-02 7.6e-03 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.93.25.72.01.91.72.2-1.61.61.40.91.72.22.40.42.12.11.7
Area under the delay curve0.50.61.10.80.90.90.8-0.90.70.40.20.30.81.10.31.00.80.9
BMI with tail9.332.255.17.46.87.17.1-6.56.06.56.05.94.54.14.93.03.03.3
BMI without tail5.717.531.75.65.05.55.1-5.04.45.04.94.12.82.54.11.71.71.6
Body weight10.847.177.18.88.58.38.3-7.47.17.47.27.56.05.55.74.04.14.4
Weight adjusted by age4.06.111.63.03.13.12.9-3.33.43.32.51.91.60.52.51.00.90.0
Bone surface0.81.42.71.51.41.11.5-1.00.91.00.81.71.31.50.71.01.11.1
Bone volume2.64.77.42.72.62.32.7-2.22.12.11.62.42.22.41.41.91.91.4
Breakpoint value in progressive ratio session0.30.41.20.70.70.80.5-0.60.20.10.20.30.51.10.10.80.50.7
Number of licking bursts0.60.92.40.60.91.00.9-0.70.20.30.61.21.11.60.11.11.01.5
Context. condit. distance diff. score0.70.82.1-0.7-0.4-0.8-1.01.4-1.4-0.80.10.9-0.9-0.6-0.1-1.4-1.1-0.8
Locomotion velocity, session 11.01.13.8-1.3-1.2-1.1-1.00.5-0.5-0.9-1.7-1.9-0.7-0.8-1.10.0-0.2-0.8
Locomotion distance, session 10.60.82.9-0.7-0.4-0.6-0.6-0.30.30.2-0.8-1.1-1.1-1.70.6-1.0-1.1-1.5
Locomotion velocity, session 20.91.13.4-0.7-0.2-0.5-0.70.1-0.10.20.3-0.1-1.2-1.91.1-1.7-1.6-1.8
Locomotion distance, session 20.91.34.01.31.11.30.9-1.81.21.40.40.1-0.7-0.52.0-0.5-0.9-1.2
Locomotion velocity, session 30.60.74.1-0.30.30.0-0.2-0.50.30.50.2-0.2-0.8-1.31.2-1.0-1.1-2.0
Locomotion distance, session 31.01.13.50.10.40.2-0.2-0.40.20.70.80.4-1.1-1.61.6-1.6-1.6-1.9
Stereotopy head waving bouts, day 30.10.10.4-0.1-0.10.30.2-0.30.30.20.3-0.60.3-0.0-0.30.40.4-0.1
Stereotopy head waving duration, day 30.40.52.0-0.9-0.7-0.5-0.30.40.0-0.5-0.3-1.10.70.2-1.41.01.00.5
Locomotion velocity, session 70.30.30.60.50.70.40.6-0.40.60.40.40.80.50.50.40.40.40.8
Locomotion distance, session 70.10.10.5-0.10.1-0.2-0.20.4-0.3-0.10.30.7-0.4-0.30.4-0.6-0.50.6
Stereotopy head waving bouts, day 70.00.00.20.20.30.30.2-0.00.10.00.10.30.10.4-0.00.20.1-0.5
Stereotopy head waving duration, day 70.50.61.10.70.90.91.0-0.80.90.60.40.41.01.00.11.11.00.0
Locomotion velocity, session 81.41.63.4-1.4-1.1-1.6-1.61.8-1.8-1.5-1.00.0-1.2-0.7-0.8-1.3-1.1-0.9
Locomotion distance, session 80.81.23.9-0.4-0.3-0.6-0.90.8-1.1-0.5-0.20.5-1.6-1.10.8-2.0-1.9-1.4
Degree of sensitization distance0.91.03.8-0.4-0.6-0.5-0.41.2-1.0-1.2-0.80.10.41.3-1.40.80.82.0
Degree of sensitization stereotypy0.10.10.60.40.30.40.4-0.10.1-0.0-0.20.40.20.8-0.10.50.40.1
Conditioned locomotion0.10.10.3-0.4-0.4-0.2-0.40.3-0.3-0.20.10.1-0.5-0.6-0.1-0.5-0.5-0.1
Cocaine response after cond. corrected2.93.56.9-1.7-1.9-1.7-2.01.2-1.5-1.2-1.4-2.0-2.6-2.5-0.2-2.2-2.4-2.3
Cocaine response after cond. not corrected3.13.75.4-2.1-2.1-2.0-2.21.6-1.8-1.5-1.4-2.0-2.3-2.3-0.7-2.0-2.0-2.0
Cocaine response before conditioning0.60.72.4-0.7-0.2-0.5-0.10.8-0.3-0.70.00.51.11.0-1.00.91.21.6
Saline control response0.60.82.3-1.2-0.8-1.0-1.10.4-0.3-0.5-1.0-0.7-1.0-1.5-0.0-0.8-0.9-0.5
Bone: connectivity density0.20.30.90.00.1-0.20.40.20.1-0.1-0.10.60.80.8-0.50.70.90.9
Bone: cortical apparent density1.92.79.8-1.3-1.1-1.2-1.50.7-0.5-0.10.3-0.9-2.1-3.10.8-2.6-2.5-2.0
Bone: cortical area8.613.121.74.74.44.34.5-4.34.04.03.23.33.33.02.82.72.62.1
Bone: cortical porosity0.10.10.60.20.10.30.00.0-0.2-0.20.30.10.10.60.00.20.10.8
Bone: cortical porosity0.60.62.00.80.70.90.7-0.40.10.10.50.70.71.40.10.90.71.4
Bone: cortical thickness4.27.011.33.43.33.13.2-3.33.23.22.72.42.11.52.41.51.41.2
Bone: cortical thickness2.73.26.82.22.32.22.0-2.01.92.22.62.20.90.52.10.20.20.4
Bone: cortical tissue density2.22.910.0-1.5-1.2-1.3-1.70.9-0.7-0.30.1-1.0-2.2-3.20.6-2.7-2.5-2.1
Condit. Reinf. active minus inactive responses0.20.21.2-0.3-0.4-0.3-0.2-0.30.10.0-0.9-1.1-0.5-0.60.0-0.2-0.4-0.3
Condit. Reinf. active-inactive response ratio0.20.21.2-0.6-0.4-0.6-0.30.0-0.1-0.2-1.1-0.8-0.2-0.4-0.4-0.0-0.0-0.0
Condit. Reinf. active responses0.40.41.50.40.10.50.7-1.21.10.8-0.3-1.00.40.00.20.80.50.2
Condit. Reinf. inactive responses0.91.12.50.90.51.11.2-1.51.61.10.4-0.71.10.60.21.41.20.9
Incentive salience index mean0.60.72.7-0.8-0.9-0.8-0.7-0.1-0.1-0.3-1.5-1.6-1.0-1.1-0.2-0.4-0.7-0.3
Condit. Reinf. lever presses0.50.62.5-0.9-0.9-0.8-0.70.0-0.0-0.4-1.4-1.6-0.8-0.9-0.5-0.2-0.40.3
Condit. Reinf. active minus inactive responses1.72.27.60.40.20.71.2-1.41.40.6-0.5-1.12.01.5-1.22.82.51.8
Condit. Reinf. active-inactive response ratio0.60.72.5-0.1-0.40.20.4-0.40.4-0.1-0.9-1.10.80.8-1.21.61.40.9
Condit. Reinf. active responses2.94.111.01.01.11.42.0-2.12.21.30.3-0.52.92.1-0.63.33.12.8
Condit. Reinf. inactive responses1.62.14.60.71.30.91.5-1.41.61.10.90.42.21.50.12.02.02.1
Condit. Reinf. lever presses0.81.12.60.90.81.11.1-1.31.10.70.20.01.21.4-0.21.61.31.2
Condit. Reinf. lever reinforcers received2.13.08.50.90.91.11.7-1.91.91.1-0.1-0.72.31.8-0.72.92.72.3
Conditioned reinforcement - actives0.50.82.8-0.1-0.1-0.1-0.5-1.00.40.0-1.3-1.7-1.2-0.90.8-0.3-1.1-1.5
Conditioned reinforcement - inactives0.30.51.50.70.80.70.7-1.21.10.6-0.1-0.50.50.50.40.80.50.5
Conditioned locomotion1.01.34.20.10.20.1-0.5-0.90.40.4-0.5-1.0-1.6-1.61.6-1.2-1.7-2.0
Patch foraging indifference point 0 sec2.54.67.22.72.52.52.7-2.52.62.31.71.92.01.71.41.81.71.5
Patch foraging indifference point AUC0.30.41.70.1-0.10.10.2-0.4-0.1-0.3-1.3-0.80.30.9-0.61.20.80.1
Delay disc. indifference point, 0s delay0.60.71.81.21.01.30.8-0.90.60.81.20.70.10.50.90.0-0.20.3
Delay disc. indifference point, 16s delay0.20.20.70.20.40.20.1-0.30.1-0.2-0.50.20.40.70.10.70.50.8
Delay disc. indifference point, 2s delay0.10.10.40.00.10.2-0.20.4-0.6-0.30.30.2-0.40.20.2-0.5-0.60.1
Delay disc. indifference point, 24s delay1.21.44.80.81.00.90.8-0.60.50.0-0.30.91.51.9-0.21.71.52.2
Delay disc. indifference point, 4s delay0.10.10.30.10.00.1-0.10.1-0.4-0.4-0.4-0.1-0.10.5-0.10.1-0.00.6
Delay disc. indifference point, 8s delay2.52.96.31.91.92.02.0-2.52.41.81.00.31.61.31.01.91.60.6
Indifference point function ln k0.10.21.0-0.1-0.2-0.10.00.30.30.31.00.30.1-0.5-0.1-0.4-0.10.7
Indifference point function log k0.10.21.0-0.1-0.2-0.10.00.30.30.31.00.30.1-0.5-0.1-0.4-0.10.7
Patch foraging total patch changes 0 sec2.54.67.22.62.52.52.7-2.52.52.21.71.92.11.91.21.91.91.6
Patch foraging total patch changes 12 sec0.91.22.81.21.21.21.3-1.10.70.60.20.91.21.70.11.61.30.7
Patch foraging total patch changes 18 sec1.92.96.31.91.61.72.0-2.11.81.3-0.20.31.82.10.22.52.11.5
Patch foraging total patch changes 24 sec1.11.94.61.61.41.31.5-1.61.30.8-0.20.21.51.90.22.11.70.9
Patch foraging total patch changes 6 sec3.75.69.02.82.82.63.0-3.02.72.51.41.72.32.21.62.32.11.5
Patch foraging time to switch 0 sec0.40.71.4-0.9-0.6-0.8-1.00.9-1.0-0.7-0.3-0.1-1.0-0.90.1-1.2-1.1-1.2
Patch foraging water rate 0 sec0.40.81.30.90.70.91.1-0.91.11.00.70.31.10.60.11.01.11.0
Patch foraging water rate 12 sec1.12.27.31.01.11.01.6-0.91.41.01.20.92.01.6-0.11.92.12.7
Patch foraging water rate 18 sec0.50.81.80.91.00.90.9-1.11.21.11.30.70.3-0.11.2-0.1-0.00.2
Patch foraging water rate 24 sec1.21.64.02.01.51.81.5-1.61.11.61.51.10.10.41.6-0.0-0.1-0.0
Patch foraging water rate 6 sec0.40.63.10.80.71.00.8-0.80.81.11.80.60.1-0.20.8-0.3-0.2-0.2
Seeking ratio, delayed vs. immediate footshock0.40.51.6-0.2-0.4-0.2-0.70.4-0.8-0.5-0.2-0.1-1.2-0.60.4-1.1-1.3-1.2
Distance traveled before self-admin1.01.34.8-0.6-0.6-0.6-0.90.8-0.8-0.00.70.1-1.4-1.80.7-2.2-1.9-1.2
Distance traveled after self-admin1.21.44.60.40.40.4-0.3-0.3-0.30.50.71.2-1.6-1.41.7-2.0-2.1-1.5
Extensor digitorum longus weight0.41.52.61.31.21.01.4-0.81.00.80.61.61.61.60.21.41.51.6
Bone: elastic displacement0.00.00.10.2-0.00.10.00.1-0.0-0.2-0.30.10.10.4-0.20.20.10.2
Bone: elastic work1.21.63.61.61.51.41.2-1.41.21.61.51.6-0.0-0.21.9-0.6-0.6-0.8
Bone: endosteal estimation1.63.56.52.62.42.42.4-2.01.51.81.82.01.52.01.61.31.20.6
Bone: endosteal perimeter4.49.315.84.03.93.73.8-3.73.33.53.02.82.52.13.01.91.80.9
Epididymis fat weight11.940.659.47.57.57.47.7-6.56.56.25.76.26.86.23.85.45.65.5
Delta time in closed arm before/after self-admin0.20.20.80.0-0.10.1-0.2-0.1-0.10.20.3-0.4-0.7-0.70.5-0.8-0.9-0.3
Delta time in open arm before/after self-admin0.60.61.60.80.70.70.9-0.70.70.4-0.10.71.01.1-0.11.31.20.4
Diff in mean of infusions in LGA sessions1.11.32.7-1.3-1.6-1.3-1.21.6-1.5-1.4-0.8-1.3-0.7-0.3-1.2-0.5-0.3-0.5
Delay discount exponential model param0.60.71.3-0.9-1.0-1.0-0.80.9-0.7-0.4-0.2-0.4-0.9-1.1-0.4-1.0-0.8-1.0
Extinction: sum of active levers before priming0.50.52.1-0.7-0.7-0.7-0.80.5-0.8-1.1-1.5-1.0-0.30.3-0.80.40.10.3
Active lever presses in extinction session 60.30.31.10.50.70.70.4-1.00.70.60.6-0.00.20.10.80.1-0.10.0
Bone: final force2.33.77.62.82.52.22.3-2.52.22.41.72.01.10.92.00.90.70.6
Bone: final moment2.74.39.53.12.72.42.5-2.62.22.51.82.21.21.22.10.90.70.7
Food consumed during 24 hour testing period0.10.10.80.1-0.00.2-0.00.2-0.30.10.70.9-0.0-0.10.2-0.5-0.30.3
Glucose2.13.36.51.82.31.82.0-1.72.02.22.52.61.80.71.70.71.00.7
Heart weight2.53.96.62.62.22.42.5-2.11.92.12.01.91.91.81.11.51.61.5
Delay discount hyperbolic model param0.40.50.9-0.8-0.9-0.9-0.70.8-0.6-0.4-0.3-0.4-0.7-1.0-0.4-0.8-0.6-0.8
Intermittent access intake day 1-15 change1.12.44.41.92.02.01.6-2.12.02.01.90.90.60.12.00.1-0.0-0.0
Intermittent access intake escalation1.02.13.91.91.91.91.6-2.01.91.91.60.80.90.41.70.30.30.1
Intermittent access intake escalation 21.11.22.81.41.31.41.0-1.51.41.51.30.60.0-0.31.7-0.3-0.4-0.6
Intermitt. access day 1 inactive lever presses0.82.86.02.01.91.91.8-1.51.40.90.61.11.92.50.42.11.82.1
Intermitt. access day 15 inactive lever presses0.10.31.40.50.40.50.3-0.70.50.3-0.3-0.20.30.40.30.60.31.2
Intermitt. access escalation Index0.00.10.30.20.10.30.10.2-0.10.10.50.50.10.2-0.1-0.2-0.1-0.4
Intermittent access day 1 total infusions0.20.41.50.60.80.70.2-1.20.60.4-0.4-0.4-0.5-0.01.00.2-0.5-0.3
Intermittent access day 15 total infusions0.50.82.61.11.31.20.7-1.61.11.00.3-0.1-0.00.11.40.1-0.3-0.2
Intermittent access terminal intake (last 3 days)0.30.41.30.70.90.90.4-1.10.60.60.40.0-0.2-0.01.1-0.1-0.5-0.4
Intermittent access total infusions0.70.83.31.01.21.20.7-1.81.31.00.0-0.5-0.00.11.20.5-0.1-0.2
Intermittent access day 1 locomotion0.40.51.90.50.70.60.0-0.90.40.50.10.0-0.9-0.71.4-0.7-1.1-0.4
Intermittent access day 15 total locomotion1.52.85.01.92.12.02.0-2.22.21.91.50.81.61.01.41.21.10.9
Intermittent access total locomotion0.91.13.21.01.21.20.7-1.41.31.41.10.3-0.3-0.81.8-0.6-0.8-0.7
Intermittent access standard deviation0.40.81.51.11.01.21.0-1.21.10.80.60.40.70.90.50.90.60.6
Left kidney weight2.09.218.44.13.83.83.3-3.12.53.64.34.00.70.93.9-0.6-0.5-0.5
Right kidney weight3.315.226.94.95.04.84.2-4.54.04.95.14.81.41.05.2-0.2-0.2-0.2
Cocaine induced anxiety3.14.47.8-2.1-2.4-2.1-2.62.5-2.8-2.2-1.0-0.7-2.6-1.8-0.9-2.5-2.4-1.3
Post-drug Anxiety0.30.30.9-0.3-0.8-0.3-0.51.0-0.9-0.70.20.6-0.20.2-0.7-0.4-0.20.4
Baseline Anxiety3.33.87.31.81.81.82.2-1.92.31.60.91.02.72.10.12.52.62.0
Tail length0.31.22.41.51.51.51.1-1.20.91.01.31.20.81.01.20.50.50.3
Length with tail1.87.813.33.53.73.33.2-2.82.82.83.03.32.62.42.31.71.81.8
Length without tail4.815.524.94.75.04.34.7-4.04.13.83.44.14.13.92.73.13.23.1
Times rat made contact with spout0.50.61.61.20.81.10.7-1.10.60.90.40.4-0.30.11.1-0.3-0.50.3
Lifetime Intake0.91.14.01.21.41.40.8-2.01.41.20.1-0.3-0.10.01.40.4-0.2-0.5
Liver weight, left5.99.717.84.23.83.83.8-3.32.93.23.33.62.62.92.71.71.71.8
Liver weight, right5.49.517.54.23.84.03.5-3.83.03.83.73.30.91.14.00.1-0.10.4
Locomotor activity1.32.14.31.31.91.51.4-1.61.91.92.11.80.9-0.01.80.00.2-0.0
Locomotor testing distance1.11.94.71.21.51.31.1-1.61.82.02.21.10.2-1.02.0-0.7-0.6-0.8
Locomotor testing rearing0.81.53.91.21.51.21.1-1.31.31.62.01.60.3-0.31.8-0.5-0.4-0.4
Locomotion in novel chamber0.81.03.7-0.00.0-0.1-0.40.0-0.30.30.50.6-1.5-1.41.3-1.9-1.9-1.2
Locomotion in novel chamber post-restriction1.32.14.0-1.7-1.6-1.5-1.71.0-1.0-1.1-1.2-1.5-1.9-2.0-0.4-1.5-1.6-1.4
Fecal boli incidents, locomotor time 10.50.72.3-0.30.20.00.6-0.71.30.5-0.1-0.61.30.2-0.51.51.51.3
Change in fecal boli incidents, locomotor task0.90.93.0-0.4-0.8-0.6-1.01.3-1.7-1.1-0.8-0.0-1.2-0.1-0.2-1.3-1.2-0.6
Time >=10cm from walls, locomotor time 11.71.83.2-1.5-1.8-1.6-1.41.7-1.7-1.5-1.3-1.3-1.0-0.6-1.5-0.7-0.6-0.6
Bouts of movement, locomotor time 11.01.12.81.40.91.31.2-1.20.80.60.0-0.11.01.70.01.61.30.8
Total resting periods, locomotor time 10.80.92.11.40.91.31.1-1.20.70.6-0.10.10.71.40.31.30.90.5
Rest time, locomotor task time 10.30.41.00.90.50.80.5-1.00.50.7-0.10.1-0.7-0.40.9-0.3-0.7-0.4
Distance moved, locomotor task time 10.10.10.6-0.20.0-0.20.00.3-0.0-0.10.40.70.80.4-0.40.30.50.4
Vertical activity count, locomotor time 10.20.41.3-0.9-0.6-0.9-0.71.1-0.7-0.50.50.2-0.2-0.6-0.5-0.9-0.4-0.4
Time >=10cm from walls, locomotor time 20.30.41.60.60.40.70.7-0.10.10.10.70.40.81.3-0.30.70.80.9
Bouts of movement, locomotor time 20.81.33.6-0.9-0.8-1.0-1.41.6-1.9-1.5-0.50.6-1.3-0.3-0.6-1.2-1.2-1.2
Total resting periods, locomotor time 20.50.82.2-0.5-0.4-0.6-1.01.1-1.5-1.1-0.40.7-1.1-0.2-0.2-1.0-1.1-1.2
Rest time, locomotor task time 20.10.20.6-0.00.40.20.1-0.30.50.50.50.60.0-0.60.8-0.4-0.3-0.5
Distance moved, locomotor task time 20.30.31.20.30.10.20.3-0.50.4-0.0-0.2-0.40.70.8-0.51.10.90.8
Vertical activity count, locomotor time 20.20.30.80.40.30.40.6-0.30.40.30.8-0.00.70.7-0.40.70.80.9
Light reinforcement 10.92.23.7-1.2-1.5-1.5-1.71.6-1.9-1.6-1.9-1.0-1.7-0.8-1.0-1.3-1.4-1.3
Light reinforcement 21.82.84.6-1.4-1.7-1.6-2.01.8-2.1-1.8-1.8-1.0-2.1-1.2-0.7-1.7-1.9-1.6
Bone: marrow area1.73.76.72.62.42.42.4-2.11.51.91.92.11.52.01.71.31.20.6
Bone: maximum diameter7.714.522.64.84.64.44.7-4.43.94.03.33.43.83.52.73.23.02.4
Bone: maximum force1.93.46.72.62.42.12.2-2.32.02.21.82.01.20.92.00.80.70.5
Bone: maximum moment2.23.88.22.92.62.32.3-2.42.02.31.82.21.21.22.00.90.70.6
Mean time between licks in bursts0.10.20.8-0.00.20.10.2-0.0-0.2-0.2-0.10.30.50.9-0.40.70.60.6
Mean num. licks in bursts0.50.82.40.50.00.1-0.1-0.50.50.70.2-0.6-1.1-1.51.0-1.4-1.4-1.5
Cd content in liver1.21.44.4-0.6-0.9-0.6-1.00.7-0.6-0.20.3-0.2-1.7-2.00.4-2.1-1.9-1.5
Co content in liver0.91.02.6-1.3-1.4-1.2-0.90.9-0.5-0.4-0.6-1.3-1.1-1.6-0.8-0.9-0.7-0.3
Cu content in liver0.20.20.4-0.5-0.5-0.4-0.40.3-0.2-0.20.0-0.6-0.6-0.6-0.2-0.6-0.50.5
Fe content in liver1.01.23.30.90.60.51.0-0.60.70.3-0.30.11.61.6-0.51.81.81.6
K content in liver0.50.51.0-1.0-0.7-0.9-0.80.9-0.7-0.9-0.9-0.8-0.5-0.3-0.7-0.2-0.3-0.1
Mg content in liver0.40.40.8-0.6-0.7-0.5-0.70.7-0.9-0.8-0.8-0.7-0.60.0-0.6-0.3-0.4-0.3
Mn content in liver0.40.41.0-0.9-0.6-0.6-0.71.0-1.0-0.8-0.10.1-0.6-0.2-0.4-0.7-0.6-0.6
Na content in liver0.40.51.0-0.9-0.5-0.9-0.81.0-0.9-1.0-0.9-0.5-0.20.1-0.70.00.00.1
Rb content in liver1.51.84.0-1.5-1.7-1.2-1.41.7-1.8-1.9-1.2-1.3-0.40.3-2.00.10.10.9
Se content in liver0.70.81.5-1.2-1.0-1.2-1.11.2-1.1-1.1-0.9-0.8-0.3-0.3-1.0-0.2-0.1-0.5
Sr content in liver2.72.44.3-1.2-1.5-1.6-1.81.5-1.4-1.2-1.3-1.1-2.1-1.8-0.6-1.9-1.9-1.7
Zn content in liver1.21.31.9-1.3-1.2-1.3-1.31.2-1.2-1.0-1.0-0.7-1.4-1.2-0.5-1.3-1.3-0.5
Bone: minimum diameter3.97.212.73.63.13.43.3-2.82.32.62.72.72.42.71.82.12.01.9
Time in familiar zone, hab. session 10.20.20.9-0.7-0.3-0.7-0.40.40.3-0.00.10.0-0.1-0.9-0.2-0.4-0.20.0
Time in novel zone, hab. session 10.80.82.41.21.01.21.0-0.90.50.50.30.50.91.60.41.10.90.6
Total zone transitions, hab. session 11.21.73.91.81.51.81.3-1.81.41.71.30.80.0-0.02.0-0.2-0.4-0.8
Total locomotion distance, hab. session 10.10.10.40.40.10.60.1-0.2-0.20.10.4-0.1-0.40.20.3-0.3-0.5-0.7
Locomotion velocity, hab. session 10.10.20.60.2-0.20.3-0.2-0.0-0.5-0.1-0.0-0.4-0.7-0.00.1-0.5-0.7-0.7
Time in familiar zone, hab. session 22.02.15.51.51.01.21.7-1.41.30.9-0.30.31.62.1-0.22.01.92.3
Time in novel zone, hab. session 21.11.14.1-0.7-0.4-0.5-0.90.5-0.4-0.10.7-0.1-1.2-1.80.6-1.5-1.5-2.0
Total zone transitions, hab. session 21.41.74.41.71.61.71.4-1.91.61.81.00.80.10.12.1-0.1-0.3-0.5
Total locomotion distance, hab. session 20.50.71.61.10.81.30.8-1.20.51.00.80.3-0.40.11.2-0.4-0.6-0.8
Locomotion velocity, hab. session 20.40.51.30.80.61.00.6-0.90.30.80.70.3-0.4-0.01.1-0.5-0.7-0.8
Novel to familiar place preference ratio0.20.20.60.00.10.10.20.1-0.0-0.2-0.10.20.70.8-0.40.70.70.5
Novelty place preference0.20.20.80.20.30.30.3-0.10.1-0.00.10.40.70.9-0.30.70.70.3
Time in novel zone, NPP test0.60.62.00.60.70.60.8-0.40.40.20.20.61.21.4-0.21.21.20.8
Total zone transitions, NPP test0.81.23.11.71.41.51.1-1.60.71.20.40.7-0.30.51.8-0.3-0.6-0.7
Total locomotion distance, NPP test0.40.61.71.30.81.30.7-1.00.00.70.40.3-0.50.51.1-0.4-0.7-0.6
Locomotion velocity, NPP test0.40.51.60.80.30.80.2-0.5-0.40.40.30.1-1.1-0.11.0-1.1-1.3-1.1
Intraocular pressure2.94.28.42.32.02.42.6-2.92.72.20.70.22.01.70.92.42.01.5
Delta distance traveled before/after self-admin0.80.82.31.21.11.20.6-1.00.40.70.51.5-0.40.21.4-0.4-0.7-0.7
Delta ambulatory time before/after self-admin0.70.82.21.41.31.30.9-1.10.50.60.31.50.31.00.90.40.1-0.2
Parametrial fat weight10.825.339.46.05.45.96.3-5.45.44.94.24.05.25.02.44.84.74.7
Pavlov. Cond. lever latency0.20.20.70.40.40.30.4-0.10.20.0-0.00.20.80.9-0.20.80.80.3
Pavlov. Cond. magazine entry latency0.20.30.50.70.60.70.5-0.70.30.60.50.4-0.10.20.7-0.2-0.30.6
Pavlov. Cond. change in total contacts0.10.10.30.10.10.10.2-0.00.10.30.20.6-0.2-0.20.3-0.4-0.30.0
Pavlov. Cond. index score0.20.30.70.50.70.60.5-0.60.40.70.70.8-0.0-0.10.9-0.3-0.30.1
Pavlov. Cond. latency score0.20.20.50.40.50.40.4-0.50.30.60.50.6-0.2-0.30.7-0.4-0.4-0.0
Pavlov. Cond. lever contacts0.10.10.4-0.5-0.4-0.3-0.30.1-0.1-0.0-0.2-0.3-0.4-0.6-0.1-0.3-0.3-0.0
Pavlov. Cond. magazine entry number1.01.32.3-1.4-1.4-1.4-1.31.5-1.2-1.5-1.4-1.2-0.4-0.2-1.40.00.1-0.5
Pavlov. Cond. intertrial magazine entries0.10.10.70.1-0.20.00.2-0.50.60.3-0.4-0.8-0.0-0.3-0.10.20.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.40.50.50.4-0.50.30.60.50.70.0-0.00.7-0.2-0.20.4
Pavlov. Cond. response bias0.10.20.50.30.40.40.3-0.50.30.60.40.3-0.2-0.40.7-0.4-0.50.4
Pavlov. Cond. lever latency0.60.82.5-0.6-0.4-0.7-0.70.9-0.7-0.20.60.4-0.9-1.40.5-1.6-1.2-1.1
Pavlov. Cond. magazine entry latency1.51.83.31.51.81.71.5-1.31.21.00.91.71.31.81.01.10.90.5
Pavlov. Cond. change in total contacts0.91.43.90.90.91.11.2-1.51.20.6-0.3-0.31.31.6-0.22.01.61.3
Pavlov. Cond. index score1.31.73.01.41.51.61.5-1.71.41.00.20.51.31.70.51.71.31.0
Pavlov. Cond. latency score1.31.83.31.41.61.61.5-1.71.41.00.30.71.31.80.61.61.31.0
Pavlov. Cond. lever contacts0.40.51.30.70.60.90.7-1.00.70.4-0.2-0.20.61.1-0.01.10.80.6
Pavlov. Cond. magazine entry number1.11.42.6-1.5-1.6-1.5-1.41.3-1.1-0.9-0.6-1.3-1.1-1.6-0.9-1.0-0.8-0.4
Pavlov. Cond. intertrial magazine entries0.10.21.20.40.20.40.4-0.20.10.30.70.40.40.20.20.10.21.1
Pavlov. Cond. lever-magazine prob. diff.1.21.73.21.41.51.61.5-1.81.51.10.40.51.21.60.71.51.20.8
Pavlov. Cond. response bias0.81.12.51.01.01.31.2-1.31.00.60.10.31.21.60.11.61.20.7
Time in closed arm before self-admin0.20.32.90.00.2-0.2-0.10.7-0.6-0.20.31.7-0.10.20.0-0.5-0.2-0.1
Time in closed arm after self-admin0.70.72.0-0.4-0.5-0.5-0.90.8-1.2-0.7-0.20.6-1.3-0.60.2-1.4-1.4-0.6
Time in open arm before self-admin1.01.12.4-1.3-1.2-1.2-1.31.2-1.3-1.3-1.0-1.6-0.7-0.5-0.8-0.5-0.50.1
Time in open arm after self-admin0.30.31.2-0.0-0.2-0.10.1-0.30.3-0.2-1.0-1.00.40.4-0.51.10.80.4
Bone: periosteal estimation5.311.319.84.54.24.14.2-3.93.33.73.33.32.72.92.92.22.11.6
Bone: periosteal perimeter9.115.725.05.04.94.74.9-4.94.44.63.53.43.52.93.42.82.72.1
Bone: post-yield work0.20.31.80.50.30.20.20.1-0.6-0.4-0.00.40.11.1-0.20.40.21.3
Progressive ratio test 1 active lever presses0.80.93.91.21.21.30.6-2.01.10.9-0.2-0.2-0.40.01.50.3-0.5-0.6
Progressive ratio test 1 breakpoint0.80.93.81.11.21.30.6-2.01.10.9-0.2-0.3-0.4-0.01.50.3-0.5-0.7
Progressive ratio test 1 inactive lever presses0.40.51.70.91.01.10.6-1.30.80.50.00.10.40.70.50.80.30.3
Progressive ratio test 2 active lever presses1.51.85.11.61.91.71.3-2.31.81.60.80.40.60.41.70.60.2-0.3
Progressive ratio test 2 breakpoint1.61.95.41.61.91.81.4-2.31.91.60.90.40.70.51.70.70.3-0.3
Progressive ratio test 2 inactive lever presses1.01.62.81.41.51.51.4-1.71.61.30.80.71.21.00.71.21.01.5
Incentive Sensitization - Responses0.91.32.41.21.61.31.3-1.41.41.31.10.61.20.80.90.90.90.6
Incentive Sensitization - Breakpoint0.91.22.11.11.41.21.3-1.31.41.21.00.51.30.80.80.90.90.6
Sum of active levers in priming session hrs 5-60.90.81.8-1.1-1.2-1.1-1.00.9-1.0-1.0-1.1-1.3-0.6-0.5-1.0-0.1-0.2-0.5
Progressive ratio0.40.71.9-1.0-1.0-1.0-0.90.6-0.7-0.9-1.4-1.3-0.5-0.4-0.7-0.1-0.2-0.6
Food seeking constrained by brief footshock0.50.61.3-0.8-0.6-0.7-0.60.7-0.6-1.1-1.1-0.10.60.9-1.10.70.70.6
Seeking ratio, punishment vs. effort0.30.41.50.70.80.70.6-0.30.40.40.91.20.40.60.30.10.20.3
Retroperitoneal fat weight11.750.076.28.68.08.58.7-7.47.37.06.46.47.36.94.06.06.16.0
Reaction time number correct0.71.32.21.41.31.21.3-1.01.00.90.91.01.31.30.61.21.21.5
Reaction time mean minus median0.20.52.10.40.70.80.6-1.41.21.00.6-0.40.1-0.40.80.2-0.1-0.8
Reaction time mean minus median AUC0.41.02.10.60.90.90.5-1.41.01.21.10.3-0.5-0.81.5-0.7-0.9-1.4
Reaction time num false alarms0.10.10.60.0-0.40.0-0.10.0-0.1-0.2-0.5-0.3-0.50.0-0.1-0.1-0.3-0.8
Reaction time num false alarms AUC0.10.10.90.1-0.20.2-0.1-0.20.1-0.0-0.1-0.3-0.6-0.20.2-0.3-0.5-1.0
Reaction time trials correct on left0.71.32.21.41.31.21.3-1.01.00.90.91.01.31.30.61.21.21.5
Reaction time trials on left0.81.52.31.41.41.21.4-1.11.01.00.91.11.31.40.61.21.21.5
Reaction time mean0.20.41.2-0.20.40.50.3-0.81.00.91.1-0.10.2-0.90.7-0.2-0.2-0.7
Reaction time mean AUC0.10.20.8-0.6-0.00.0-0.1-0.40.50.40.6-0.4-0.1-0.90.3-0.3-0.2-0.6
Median of all reaction times0.20.31.3-0.30.20.30.1-0.50.80.71.10.00.1-1.00.7-0.4-0.3-0.7
Reaction time omissions0.20.30.60.80.50.50.7-0.70.60.5-0.10.30.50.7-0.10.70.60.7
Reaction time false alarm rate0.40.51.6-0.6-0.9-0.4-0.70.4-0.5-0.6-0.7-0.8-1.0-0.6-0.3-0.6-0.8-1.3
Reaction time premature initiation rate0.70.93.00.70.70.80.3-0.80.70.91.10.2-0.7-1.01.4-1.0-1.1-1.7
Reaction time premature initiations0.91.63.61.51.51.51.1-1.51.41.61.80.9-0.0-0.41.9-0.4-0.5-1.0
Std. dev. reaction times0.91.74.91.11.41.61.4-2.22.01.81.40.10.8-0.01.30.60.4-0.2
Reaction time trials completed0.81.52.31.41.41.21.4-1.11.01.00.91.11.31.40.61.21.21.5
Reaction time trials AUC0.81.52.21.51.41.31.4-1.21.11.01.01.01.31.40.71.31.21.5
Run reversals in cocaine runway, females0.90.92.00.91.31.01.0-1.41.41.30.70.70.1-0.21.3-0.1-0.2-0.5
Run reversals in cocaine runway, males0.90.92.3-1.1-1.0-1.1-1.11.5-1.5-1.4-0.9-0.3-0.50.1-1.0-0.4-0.30.5
Latency to leave start box in cocaine runway0.70.81.4-1.1-0.8-1.0-1.21.0-1.0-0.9-1.0-0.7-0.8-0.9-0.2-0.9-0.8-0.7
Latency to leave start box in cocaine runway, F0.91.01.9-1.2-1.2-1.2-1.31.4-1.3-1.1-0.8-0.4-0.8-0.9-0.6-1.0-0.8-0.4
Latency to leave start box in cocaine runway, M0.10.10.60.30.60.40.1-0.50.30.2-0.1-0.1-0.00.10.8-0.1-0.2-0.5
Std. dev. time between licks in bursts0.30.41.5-0.6-0.7-0.3-0.40.3-0.8-0.9-1.2-0.9-0.60.6-0.80.40.0-0.3
Total sessions with >9 infusions2.12.67.22.02.02.11.7-2.72.32.11.20.40.50.21.80.60.1-1.0
Short access day 1 total inactive lever presses0.50.71.91.01.11.00.8-0.60.30.40.60.91.01.40.20.70.71.1
Short access day 10 total inactive lever presses0.30.71.21.11.01.11.0-0.91.00.91.10.80.70.60.60.30.40.4
Short access day 1 total infusions0.50.61.60.90.91.00.5-1.10.80.90.60.3-0.3-0.21.1-0.3-0.6-1.3
Short access day 10 total infusions0.40.62.6-0.10.10.1-0.3-0.90.40.2-0.4-0.9-1.0-0.90.8-0.4-1.0-1.6
Short access total infusions0.70.92.90.90.91.00.4-1.71.11.0-0.0-0.5-0.7-0.61.4-0.3-0.9-1.5
Short access day 1 locomotion0.50.62.30.80.81.00.5-1.50.90.80.1-0.1-0.2-0.21.10.1-0.4-1.0
Short access day 10 total locomotion0.71.33.11.31.31.31.1-1.21.11.61.81.10.0-0.41.6-0.5-0.40.2
Short access total locomotion1.11.33.51.21.11.30.7-1.71.21.40.80.3-0.7-0.81.9-0.6-1.0-1.2
One hour access (0.3 mA shock)1.11.32.81.21.31.31.0-1.71.30.7-0.20.01.11.40.41.61.10.9
Compulsive drug intake0.40.51.70.30.2-0.00.20.0-0.2-0.4-0.9-0.30.71.3-0.51.00.91.3
One hour access (shock baseline)0.50.82.20.91.01.20.7-1.51.31.10.80.30.1-0.11.20.2-0.2-0.6
Social response proportion2.63.07.52.22.21.81.4-1.91.62.12.01.9-0.3-0.62.7-1.0-1.1-1.3
Social responses4.25.410.42.93.02.92.7-3.22.92.72.11.61.71.42.11.61.30.7
Social time1.62.24.91.62.11.71.4-1.81.61.81.71.80.50.12.2-0.1-0.2-0.4
Soleus weight3.29.315.13.73.93.83.4-3.53.43.83.83.81.51.03.80.30.40.2
Bone: stiffness0.91.52.71.51.61.31.5-1.61.61.71.31.20.80.31.40.50.40.2
Tibialis anterior weight0.20.61.7-0.4-0.3-0.6-0.00.20.0-0.5-1.3-0.00.80.7-1.01.31.21.2
Time to tail flick, vehicle, before self-admin0.60.61.10.60.60.80.9-0.81.00.81.0-0.21.00.50.00.80.90.8
Time to tail flick, vehicle, after self-admin0.30.41.2-0.6-0.8-0.7-0.40.6-0.6-0.5-0.5-1.00.1-0.0-0.90.10.31.1
Time to tail flick, test, before self-admin2.12.111.00.30.30.2-0.3-0.70.20.70.40.1-1.8-2.01.9-1.9-2.2-3.3
Time to tail flick, test, after self-admin0.60.61.20.80.90.90.8-1.11.00.60.20.60.70.70.40.90.70.6
Delta time to tail flick, vehicle, before/after SA0.20.20.8-0.2-0.3-0.3-0.10.3-0.3-0.4-0.7-0.20.30.5-0.60.50.50.9
Delta time to tail flick, test, before/after SA1.11.14.30.40.50.50.9-0.61.00.40.10.01.51.1-0.61.61.72.1
Tibia length1.64.47.92.72.62.62.4-2.62.32.82.72.20.70.42.7-0.0-0.0-0.2
Ambulatory time before self-admin0.71.02.90.20.30.30.0-0.10.10.81.61.0-0.8-1.41.3-1.7-1.4-1.2
Ambulatory time after self-admin1.41.64.10.90.90.90.3-0.60.11.01.52.0-1.1-1.11.9-1.8-1.7-1.5
Bone: tissue strength0.20.20.8-0.3-0.4-0.7-0.50.6-0.5-0.6-0.9-0.3-0.10.1-0.70.00.00.2
Total heroin consumption1.61.93.41.81.71.81.6-1.61.31.21.11.41.31.50.71.31.10.3
Bone: trabecular number0.91.44.10.90.70.41.1-0.50.70.3-0.30.91.61.9-0.51.81.82.0
Bone: trabecular spacing0.10.10.5-0.7-0.3-0.3-0.40.4-0.4-0.40.1-0.40.0-0.1-0.2-0.1-0.00.5
Bone: trabecular thickness4.86.09.63.02.82.93.1-2.82.52.41.92.02.62.61.32.42.31.3
Bone: trabecular tissue density0.40.51.70.50.70.40.3-0.90.81.00.90.1-0.2-0.91.3-0.6-0.6-1.0
Water consumed over 24 hours0.60.82.01.11.11.00.7-0.90.71.11.11.0-0.0-0.21.4-0.6-0.50.1
Number of responses in last shaping day0.10.10.70.10.00.1-0.1-0.40.20.2-0.2-0.2-0.5-0.40.2-0.2-0.5-0.8