Hub : Genes

LOC102550304

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr3_151976874_151977433 0.04 0.03 1.1e-03 0.02 0.02 0.01 0.01 3.6e-03 6.6e-03 2.6e-02 9.6e-03
2 Liver intron excision ratio chr3_151976874_151977256 0.04 0.03 9.7e-04 0.01 0.02 0.01 0.01 1.1e-02 5.7e-03 3.1e-02 9.6e-03
3 BLA gene expression LOC102550304 0.7 0.13 0.0e+00 0.55 0.37 0.54 0.55 3.8e-34 1.2e-20 4.4e-33 2.2e-34
4 pVTA gene expression LOC102550304 0.43 0.11 0.0e+00 0.48 0.47 0.49 0.49 3.7e-43 2.0e-42 9.4e-45 1.7e-44
5 NAcc gene expression LOC102550304 0.31 0.1 0.0e+00 0.38 0.33 0.39 0.38 8.1e-62 6.6e-51 1.3e-62 2.7e-60
6 Brain gene expression LOC102550304 0.5 0.11 0.0e+00 0.62 0.6 0.62 0.62 1.7e-73 4.4e-69 3.9e-74 1.3e-72
7 LHb gene expression LOC102550304 0.53 0.15 1.8e-11 0.37 0.35 0.34 0.24 9.3e-10 3.1e-09 4.9e-09 2.0e-06
8 IC gene expression LOC102550304 0.6 0.17 0.0e+00 0.47 0.47 0.46 0.48 4.2e-22 7.3e-22 2.3e-21 1.6e-22
9 OFC gene expression LOC102550304 0.64 0.13 1.6e-15 0.52 0.48 0.53 0.5 2.4e-14 3.2e-13 1.2e-14 9.8e-14
10 Adipose gene expression LOC102550304 0.65 0.12 0.0e+00 0.41 0.43 0.43 0.43 3.2e-49 1.5e-51 1.0e-51 1.9e-51
11 PL gene expression LOC102550304 0.57 0.1 0.0e+00 0.64 0.45 0.64 0.63 8.4e-92 1.4e-54 2.7e-90 2.9e-89
12 RMTg gene expression LOC102550304 0.22 0.12 8.2e-05 0.1 0.12 0.1 0.09 1.4e-03 5.8e-04 1.6e-03 2.4e-03
13 Liver gene expression LOC102550304 0.51 0.13 0.0e+00 0.39 0.38 0.39 0.38 1.5e-45 1.8e-44 5.0e-46 1.8e-44
14 IL gene expression LOC102550304 0.53 0.18 7.1e-10 0.26 0.3 0.4 0.31 6.7e-07 6.4e-08 1.5e-10 4.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.00.20.4-0.2-0.1-0.0-0.0-0.10.00.0-0.0-0.1-0.0-0.0-0.10.4
Area under the delay curve0.30.32.01.4-0.70.20.20.2-0.20.20.30.4-0.10.3-0.00.11.1
BMI with tail10.335.641.4-6.26.46.46.26.26.26.16.26.36.16.16.15.72.0
BMI without tail8.927.331.9-5.35.65.75.65.65.45.35.65.55.35.45.34.61.4
Body weight11.550.463.0-7.87.97.77.47.47.47.37.27.27.37.37.16.70.9
Weight adjusted by age0.20.22.20.4-0.10.0-0.3-0.3-0.20.4-0.2-0.5-0.1-0.3-0.30.1-1.5
Bone surface0.20.30.5-0.70.70.40.70.70.60.40.60.60.50.50.60.4-0.0
Bone volume0.00.00.1-0.30.30.20.30.20.20.10.20.20.10.10.20.0-0.3
Breakpoint value in progressive ratio session0.20.20.4-0.60.60.40.50.50.50.40.40.50.40.40.50.4-0.0
Number of licking bursts0.10.20.6-0.10.20.30.40.40.40.30.50.50.40.50.40.10.8
Context. condit. distance diff. score0.00.00.2-0.20.1-0.1-0.0-0.00.00.10.0-0.20.1-0.00.00.0-0.5
Locomotion velocity, session 11.71.82.31.3-1.2-1.5-1.3-1.3-1.4-1.5-1.4-1.2-1.4-1.4-1.5-1.4-1.1
Locomotion distance, session 14.35.46.82.5-2.4-2.6-2.3-2.3-2.4-2.6-2.4-2.3-2.4-2.3-2.4-2.2-0.7
Locomotion velocity, session 21.41.63.31.8-1.6-1.3-1.3-1.3-1.3-1.2-1.2-1.0-1.3-1.2-1.3-1.00.3
Locomotion distance, session 25.98.29.82.7-2.8-3.1-2.9-2.9-2.9-3.1-2.9-2.9-2.9-2.9-3.0-3.0-1.8
Locomotion velocity, session 33.43.85.12.1-2.1-2.1-2.0-2.0-2.0-2.3-2.0-1.8-2.0-2.0-1.9-2.1-0.1
Locomotion distance, session 31.11.21.71.3-1.3-1.1-1.1-1.1-1.1-1.1-1.1-0.7-1.1-1.1-1.0-1.20.5
Stereotopy head waving bouts, day 30.00.00.1-0.20.0-0.2-0.1-0.1-0.1-0.3-0.2-0.1-0.2-0.2-0.2-0.2-0.3
Stereotopy head waving duration, day 30.00.00.2-0.40.30.00.10.10.1-0.00.10.00.10.10.00.1-0.3
Locomotion velocity, session 71.31.51.91.0-1.0-1.3-1.2-1.2-1.2-1.4-1.3-1.2-1.3-1.3-1.3-0.9-1.1
Locomotion distance, session 70.30.41.40.1-0.2-0.8-0.5-0.5-0.5-0.7-0.6-0.8-0.6-0.6-0.7-0.4-1.2
Stereotopy head waving bouts, day 70.20.30.5-0.30.40.60.50.50.50.50.50.70.50.50.50.60.7
Stereotopy head waving duration, day 70.10.10.20.5-0.3-0.1-0.3-0.2-0.3-0.2-0.2-0.0-0.3-0.2-0.1-0.10.4
Locomotion velocity, session 81.21.51.91.0-1.0-1.3-1.2-1.2-1.2-1.4-1.3-1.4-1.3-1.3-1.4-1.0-1.0
Locomotion distance, session 82.94.25.71.8-1.9-2.4-2.0-2.0-2.0-2.1-2.0-2.4-2.0-2.0-2.2-2.0-1.5
Degree of sensitization distance0.50.51.8-1.11.10.50.70.60.60.50.50.20.60.60.40.8-1.3
Degree of sensitization stereotypy0.50.50.7-0.50.70.80.70.70.70.80.70.80.80.70.80.80.6
Conditioned locomotion0.30.31.40.3-0.2-0.3-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.5-0.6-0.7-1.2
Cocaine response after cond. corrected1.82.23.01.0-1.3-1.7-1.5-1.5-1.4-1.5-1.5-1.7-1.4-1.6-1.6-1.4-1.6
Cocaine response after cond. not corrected2.83.34.21.5-1.7-2.0-1.8-1.9-1.9-1.9-1.8-2.0-1.8-1.9-1.9-1.7-1.6
Cocaine response before conditioning0.10.10.40.6-0.5-0.2-0.2-0.2-0.3-0.4-0.2-0.1-0.4-0.2-0.3-0.30.4
Saline control response0.50.76.7-1.10.9-0.10.40.30.3-0.10.2-0.30.10.1-0.10.1-2.6
Bone: connectivity density0.10.20.50.7-0.6-0.5-0.3-0.3-0.4-0.4-0.3-0.4-0.4-0.3-0.4-0.50.2
Bone: cortical apparent density0.10.20.70.7-0.7-0.3-0.3-0.3-0.3-0.2-0.2-0.3-0.3-0.2-0.2-0.00.8
Bone: cortical area0.40.71.0-0.50.60.81.00.90.80.81.01.00.70.90.70.80.7
Bone: cortical porosity0.50.60.9-0.50.50.80.70.70.70.90.80.70.80.80.60.60.9
Bone: cortical porosity0.80.81.1-0.80.81.01.01.00.91.01.00.91.01.00.80.60.8
Bone: cortical thickness0.71.14.80.00.30.91.01.00.80.91.11.10.81.10.81.02.2
Bone: cortical thickness0.30.31.51.2-0.8-0.2-0.3-0.3-0.40.1-0.2-0.1-0.4-0.2-0.4-0.01.2
Bone: cortical tissue density0.10.20.50.6-0.7-0.4-0.4-0.4-0.4-0.3-0.3-0.4-0.4-0.3-0.3-0.10.7
Condit. Reinf. active minus inactive responses0.00.10.40.0-0.2-0.1-0.2-0.2-0.1-0.1-0.1-0.0-0.1-0.1-0.0-0.40.6
Condit. Reinf. active-inactive response ratio0.00.00.20.2-0.2-0.0-0.2-0.2-0.2-0.1-0.10.0-0.1-0.1-0.1-0.50.4
Condit. Reinf. active responses0.10.10.20.2-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.2-0.2-0.3-0.2-0.40.5
Condit. Reinf. inactive responses0.00.00.1-0.10.1-0.2-0.0-0.0-0.0-0.1-0.1-0.1-0.1-0.1-0.10.1-0.4
Incentive salience index mean0.20.32.10.7-0.7-0.3-0.4-0.4-0.4-0.3-0.3-0.0-0.3-0.3-0.2-0.51.4
Condit. Reinf. lever presses0.30.55.40.6-0.40.20.10.10.10.20.20.50.20.20.30.32.3
Condit. Reinf. active minus inactive responses0.81.02.1-1.51.30.81.01.01.01.10.90.71.00.90.81.1-0.8
Condit. Reinf. active-inactive response ratio0.80.91.4-1.21.20.80.90.91.01.10.90.71.10.90.90.9-0.4
Condit. Reinf. active responses0.81.12.0-1.11.11.01.11.01.11.21.11.11.11.01.01.40.4
Condit. Reinf. inactive responses0.40.52.5-0.20.30.70.50.60.50.50.60.90.50.60.71.01.6
Condit. Reinf. lever presses2.53.55.0-2.22.21.82.01.92.01.81.91.72.01.81.91.90.6
Condit. Reinf. lever reinforcers received0.91.32.0-1.31.21.11.11.11.21.21.11.11.11.11.11.40.3
Conditioned reinforcement - actives1.72.96.30.5-1.0-1.9-1.4-1.4-1.5-2.5-1.6-2.0-1.8-1.4-1.8-2.2-1.9
Conditioned reinforcement - inactives2.94.38.10.7-1.3-2.1-1.9-2.0-1.9-2.3-2.1-2.6-2.0-2.0-2.1-2.3-2.9
Conditioned locomotion0.81.12.90.9-1.0-1.2-0.7-0.7-0.9-1.7-0.8-1.1-1.2-0.6-0.9-1.40.7
Patch foraging indifference point 0 sec0.81.53.20.1-0.5-1.4-1.2-1.2-1.1-1.3-1.4-1.5-1.1-1.4-1.2-1.0-1.8
Patch foraging indifference point AUC0.50.81.71.3-1.3-1.0-0.8-0.8-0.8-0.7-0.7-0.6-0.8-0.6-0.8-0.80.9
Delay disc. indifference point, 0s delay1.21.34.2-0.10.61.21.11.11.01.11.21.21.01.31.11.12.1
Delay disc. indifference point, 16s delay0.70.82.61.6-1.3-0.8-0.7-0.7-0.9-0.8-0.6-0.5-0.9-0.6-0.8-0.80.9
Delay disc. indifference point, 2s delay1.71.93.0-0.20.91.51.51.51.21.41.61.61.21.71.31.21.7
Delay disc. indifference point, 24s delay2.12.46.22.5-2.0-1.3-1.4-1.5-1.7-1.4-1.3-1.0-1.7-1.6-1.6-1.10.0
Delay disc. indifference point, 4s delay1.31.42.3-0.00.71.31.41.41.01.21.41.51.01.51.11.11.1
Delay disc. indifference point, 8s delay0.40.52.91.7-1.1-0.3-0.5-0.5-0.8-0.2-0.4-0.2-0.7-0.4-0.7-0.40.2
Indifference point function ln k0.10.21.6-0.10.30.2-0.2-0.2-0.2-0.1-0.3-0.1-0.3-0.4-0.30.0-1.3
Indifference point function log k0.10.21.6-0.10.30.2-0.2-0.2-0.2-0.1-0.3-0.1-0.3-0.4-0.30.0-1.3
Patch foraging total patch changes 0 sec1.01.93.00.4-0.7-1.5-1.4-1.4-1.3-1.5-1.6-1.7-1.3-1.5-1.4-1.2-1.7
Patch foraging total patch changes 12 sec0.10.10.2-0.30.40.10.40.40.40.30.40.20.30.40.20.5-0.1
Patch foraging total patch changes 18 sec1.62.53.81.1-1.4-1.9-1.7-1.7-1.5-1.7-1.7-1.9-1.6-1.6-1.6-1.6-1.1
Patch foraging total patch changes 24 sec0.20.30.70.2-0.4-0.9-0.5-0.5-0.4-0.5-0.5-0.8-0.4-0.5-0.5-0.5-0.3
Patch foraging total patch changes 6 sec0.40.61.10.3-0.5-1.0-0.9-0.9-0.7-0.8-0.9-1.0-0.7-0.9-0.7-0.7-0.4
Patch foraging time to switch 0 sec1.73.54.5-1.81.92.11.91.92.02.11.91.72.01.91.92.10.3
Patch foraging water rate 0 sec1.93.94.82.0-2.1-2.2-2.1-2.0-2.1-2.1-2.0-1.9-2.0-2.0-2.0-2.10.0
Patch foraging water rate 12 sec1.94.06.32.5-2.4-2.0-2.0-2.0-2.1-2.2-1.9-1.8-2.1-1.9-1.9-1.90.6
Patch foraging water rate 18 sec7.511.613.23.6-3.5-3.4-3.6-3.5-3.6-3.3-3.5-3.4-3.6-3.4-3.6-3.1-2.3
Patch foraging water rate 24 sec4.05.66.62.3-2.3-2.5-2.4-2.4-2.4-2.3-2.4-2.4-2.3-2.5-2.5-2.6-1.4
Patch foraging water rate 6 sec4.26.27.42.7-2.7-2.5-2.6-2.6-2.6-2.5-2.6-2.3-2.6-2.6-2.6-2.4-0.8
Seeking ratio, delayed vs. immediate footshock0.20.20.7-0.80.60.60.20.20.40.70.20.30.50.10.30.3-0.3
Distance traveled before self-admin0.60.71.4-0.40.70.90.91.00.90.71.01.20.91.00.90.60.9
Distance traveled after self-admin0.20.21.01.0-0.7-0.2-0.3-0.3-0.3-0.2-0.2-0.2-0.2-0.2-0.2-0.50.6
Extensor digitorum longus weight0.10.30.7-0.80.80.70.50.40.50.30.40.60.40.40.40.4-0.7
Bone: elastic displacement0.60.71.9-0.50.70.80.70.70.80.80.70.80.90.80.81.21.4
Bone: elastic work4.05.36.0-1.82.12.52.32.32.32.52.32.42.32.42.32.42.1
Bone: endosteal estimation1.43.16.5-2.62.41.61.71.71.71.51.61.51.61.41.61.2-2.0
Bone: endosteal perimeter0.30.64.9-1.21.00.10.40.40.30.20.20.10.20.20.2-0.2-2.2
Epididymis fat weight9.030.639.6-6.06.36.15.75.75.75.75.65.75.85.55.55.20.9
Delta time in closed arm before/after self-admin0.20.20.40.4-0.5-0.4-0.6-0.6-0.5-0.1-0.6-0.5-0.4-0.6-0.5-0.0-0.2
Delta time in open arm before/after self-admin1.71.73.0-1.71.51.21.41.41.40.91.31.41.31.21.50.80.3
Diff in mean of infusions in LGA sessions0.40.52.8-0.10.20.60.50.60.60.60.60.80.60.70.80.61.7
Delay discount exponential model param0.30.32.4-1.60.8-0.10.00.00.4-0.0-0.1-0.30.3-0.10.20.0-0.9
Extinction: sum of active levers before priming0.50.50.80.4-0.5-0.6-0.9-0.8-0.7-0.5-0.9-0.6-0.7-0.9-0.7-0.6-0.9
Active lever presses in extinction session 61.21.22.0-1.41.40.91.31.31.20.81.21.01.11.21.01.00.1
Bone: final force0.71.01.5-0.81.01.21.11.11.01.11.21.21.01.11.00.80.6
Bone: final moment0.50.91.3-0.70.91.01.01.00.91.01.01.10.91.00.90.80.6
Food consumed during 24 hour testing period0.20.30.4-0.50.60.50.70.70.60.30.60.60.40.60.40.6-0.4
Glucose0.50.81.9-1.41.31.00.80.80.90.80.70.90.80.70.70.8-0.5
Heart weight1.21.93.0-1.41.71.31.71.71.41.11.71.21.31.61.21.1-0.4
Delay discount hyperbolic model param0.30.31.4-1.20.4-0.4-0.4-0.40.0-0.4-0.5-0.6-0.0-0.5-0.1-0.3-1.0
Intermittent access intake day 1-15 change0.30.72.4-1.51.20.51.00.90.80.20.80.40.70.90.70.5-0.3
Intermittent access intake escalation0.20.41.7-1.31.00.40.80.70.60.00.60.30.50.70.50.4-0.3
Intermittent access intake escalation 20.60.72.2-1.51.20.61.01.00.90.20.90.70.80.90.80.40.3
Intermitt. access day 1 inactive lever presses0.31.16.70.6-0.5-0.5-1.0-1.0-0.9-0.3-1.1-0.8-0.9-1.0-1.0-0.2-2.6
Intermitt. access day 15 inactive lever presses0.51.16.9-1.10.3-0.7-0.7-0.7-0.5-0.8-1.0-1.1-0.7-0.9-0.7-0.6-2.6
Intermitt. access escalation Index0.40.61.0-0.50.70.90.70.70.81.00.80.80.90.70.80.9-0.1
Intermittent access day 1 total infusions0.00.10.3-0.10.20.30.30.30.20.30.20.20.10.20.10.3-0.5
Intermittent access day 15 total infusions0.50.71.7-1.31.10.71.01.00.80.40.80.50.60.90.50.8-0.8
Intermittent access terminal intake (last 3 days)0.81.02.4-1.61.30.91.21.21.10.61.00.80.91.10.81.0-0.3
Intermittent access total infusions0.30.31.1-1.10.80.40.60.60.60.20.50.30.40.60.40.3-0.5
Intermittent access day 1 locomotion0.10.10.70.9-0.50.00.10.1-0.2-0.20.10.1-0.30.2-0.2-0.10.4
Intermittent access day 15 total locomotion0.10.20.4-0.60.50.10.60.60.5-0.20.5-0.00.30.60.3-0.10.7
Intermittent access total locomotion0.10.10.50.3-0.3-0.30.10.1-0.1-0.60.0-0.3-0.30.2-0.2-0.50.7
Intermittent access standard deviation0.10.20.8-0.1-0.2-0.6-0.4-0.4-0.4-0.9-0.5-0.6-0.5-0.5-0.4-0.5-0.4
Left kidney weight1.25.78.3-2.92.82.52.52.52.52.32.42.42.42.52.42.2-0.0
Right kidney weight0.31.42.9-1.71.51.21.31.21.20.81.31.11.11.21.20.9-0.3
Cocaine induced anxiety0.30.40.60.6-0.6-0.6-0.6-0.6-0.7-0.7-0.6-0.6-0.7-0.6-0.7-0.8-0.7
Post-drug Anxiety0.60.71.7-0.80.91.00.60.60.71.30.70.80.80.60.71.0-0.4
Baseline Anxiety3.84.47.5-1.92.12.31.91.92.12.72.02.12.21.92.22.50.7
Tail length0.51.92.8-1.51.71.51.51.51.51.31.51.31.51.51.31.0-0.3
Length with tail1.98.412.8-3.53.63.13.03.03.02.92.92.73.03.02.72.6-0.9
Length without tail1.85.78.6-2.92.82.62.42.42.52.52.32.22.42.42.32.4-0.4
Times rat made contact with spout2.93.34.6-2.12.11.72.02.02.01.81.91.71.91.91.81.80.1
Lifetime Intake0.10.20.8-0.90.60.10.40.40.4-0.20.30.10.20.40.30.0-0.2
Liver weight, left1.72.84.3-2.12.01.81.61.61.61.91.61.51.71.51.51.7-1.2
Liver weight, right2.03.44.8-2.12.22.11.81.81.82.11.82.11.81.71.71.6-1.0
Locomotor activity0.10.20.4-0.40.50.50.50.50.50.60.40.60.50.40.40.4-0.0
Locomotor testing distance0.00.10.20.5-0.4-0.4-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.3-0.30.0
Locomotor testing rearing0.00.00.1-0.10.1-0.20.20.20.30.20.2-0.10.20.20.1-0.10.1
Locomotion in novel chamber2.22.83.71.5-1.5-1.6-1.9-1.8-1.7-1.1-1.9-1.8-1.6-1.8-1.6-1.6-1.9
Locomotion in novel chamber post-restriction2.03.34.41.9-1.8-1.7-1.8-1.8-1.8-2.1-1.9-1.8-1.9-1.7-1.8-2.1-1.0
Fecal boli incidents, locomotor time 11.01.53.61.1-0.9-0.9-1.1-1.1-1.3-1.2-1.2-1.1-1.3-1.2-1.4-1.3-1.9
Change in fecal boli incidents, locomotor task0.20.10.30.1-0.3-0.5-0.5-0.5-0.3-0.2-0.5-0.4-0.3-0.5-0.2-0.3-0.2
Time >=10cm from walls, locomotor time 10.40.40.60.6-0.6-0.5-0.6-0.6-0.7-0.7-0.6-0.5-0.6-0.7-0.6-0.7-0.3
Bouts of movement, locomotor time 11.21.41.91.2-1.2-1.1-1.2-1.1-1.2-1.3-1.2-1.3-1.2-1.0-1.4-1.1-1.0
Total resting periods, locomotor time 12.12.32.91.4-1.5-1.5-1.6-1.5-1.6-1.7-1.6-1.7-1.6-1.5-1.7-1.4-1.2
Rest time, locomotor task time 10.70.92.50.3-0.5-0.9-1.0-1.0-0.9-0.9-1.0-1.1-0.8-1.0-1.0-0.9-1.6
Distance moved, locomotor task time 10.30.53.91.2-0.8-0.3-0.1-0.1-0.3-0.30.10.3-0.4-0.0-0.2-0.02.0
Vertical activity count, locomotor time 10.40.92.1-0.40.60.91.11.10.90.61.11.10.71.01.00.71.4
Time >=10cm from walls, locomotor time 20.91.41.8-1.31.41.31.21.21.21.21.21.21.21.21.11.2-0.2
Bouts of movement, locomotor time 20.20.40.9-0.20.40.60.60.60.60.90.70.70.60.60.40.7-0.6
Total resting periods, locomotor time 20.20.40.8-0.30.40.60.60.60.60.90.70.60.60.60.40.7-0.7
Rest time, locomotor task time 20.10.10.40.1-0.1-0.1-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.4-0.3-0.2-0.6
Distance moved, locomotor task time 20.30.40.91.0-0.9-0.6-0.5-0.5-0.5-0.4-0.4-0.3-0.6-0.4-0.5-0.40.8
Vertical activity count, locomotor time 20.10.10.50.1-0.10.20.30.30.20.20.40.50.20.30.30.10.7
Light reinforcement 10.20.41.6-0.1-0.1-0.7-0.3-0.3-0.4-0.9-0.4-0.9-0.6-0.4-0.6-0.7-1.3
Light reinforcement 20.61.04.30.1-0.3-0.8-0.7-0.8-0.8-1.1-0.9-1.1-0.8-0.8-1.0-1.1-2.1
Bone: marrow area1.43.06.4-2.52.41.61.71.71.61.51.51.51.51.41.51.1-2.1
Bone: maximum diameter0.61.02.5-1.61.40.71.11.11.00.71.00.80.90.90.80.5-1.2
Bone: maximum force0.40.81.1-0.80.81.01.00.90.80.91.01.10.80.90.80.60.7
Bone: maximum moment0.40.71.0-0.70.80.90.90.90.80.80.91.00.80.90.80.70.9
Mean time between licks in bursts0.20.40.50.7-0.7-0.6-0.6-0.6-0.6-0.5-0.6-0.6-0.6-0.6-0.5-0.7-0.6
Mean num. licks in bursts0.40.61.3-1.11.10.60.70.70.80.60.60.50.70.60.60.9-0.7
Cd content in liver0.10.10.2-0.10.30.50.20.20.20.30.20.50.30.20.40.40.2
Co content in liver0.40.50.70.8-0.6-0.7-0.7-0.8-0.7-0.6-0.8-0.8-0.8-0.8-0.8-0.3-0.8
Cu content in liver0.30.40.60.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.5-0.7-0.6-0.7-0.4-0.8
Fe content in liver1.61.92.6-1.31.31.51.41.41.41.61.51.51.41.41.41.50.7
K content in liver0.80.83.21.8-1.3-0.5-0.7-0.7-0.8-0.4-0.5-0.5-0.7-0.6-0.6-0.31.6
Mg content in liver0.00.00.20.2-0.10.20.00.00.00.20.10.10.10.00.20.20.5
Mn content in liver2.22.44.51.2-1.2-1.6-1.5-1.5-1.5-1.7-1.5-1.6-1.5-1.6-1.5-1.6-2.1
Na content in liver0.50.63.50.10.10.50.60.60.60.80.70.60.60.70.60.81.9
Rb content in liver0.40.51.0-0.60.50.90.60.60.60.80.70.80.60.60.71.00.3
Se content in liver0.70.81.3-0.30.60.90.90.90.81.00.91.00.80.90.81.11.0
Sr content in liver0.90.70.90.7-0.8-1.0-0.8-0.8-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.7
Zn content in liver0.10.10.50.7-0.5-0.1-0.2-0.2-0.20.0-0.1-0.1-0.2-0.1-0.3-0.00.5
Bone: minimum diameter0.40.81.1-1.11.10.91.01.01.00.81.00.90.90.90.90.70.0
Time in familiar zone, hab. session 10.50.52.9-0.40.30.50.50.50.60.60.60.90.60.50.80.61.7
Time in novel zone, hab. session 10.20.22.1-0.20.30.20.10.10.00.10.1-0.10.00.1-0.1-0.3-1.4
Total zone transitions, hab. session 10.91.31.61.3-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.0-1.2-1.2-1.2-1.1-0.1
Total locomotion distance, hab. session 11.62.22.61.6-1.6-1.6-1.6-1.6-1.6-1.4-1.6-1.4-1.6-1.5-1.6-1.2-0.7
Locomotion velocity, hab. session 12.02.93.51.9-1.9-1.8-1.8-1.8-1.8-1.7-1.8-1.7-1.8-1.7-1.8-1.4-0.4
Time in familiar zone, hab. session 20.40.41.10.3-0.6-0.8-0.6-0.6-0.6-0.9-0.6-0.6-0.6-0.7-0.6-1.0-0.1
Time in novel zone, hab. session 20.90.91.3-0.91.11.11.01.01.01.20.90.91.01.00.91.2-0.4
Total zone transitions, hab. session 20.20.31.50.2-0.2-0.6-0.3-0.4-0.4-0.6-0.4-0.7-0.4-0.4-0.5-0.5-1.2
Total locomotion distance, hab. session 21.52.05.00.8-0.9-1.5-1.3-1.3-1.3-1.4-1.4-1.6-1.3-1.3-1.5-1.4-2.2
Locomotion velocity, hab. session 22.12.94.41.3-1.4-1.8-1.6-1.6-1.7-1.7-1.7-1.9-1.7-1.7-1.8-1.7-2.1
Novel to familiar place preference ratio0.00.10.2-0.40.30.10.10.20.20.40.10.00.30.10.2-0.10.1
Novelty place preference0.10.10.2-0.40.30.20.20.20.30.50.20.20.40.20.4-0.10.4
Time in novel zone, NPP test0.30.30.6-0.80.60.50.50.50.60.80.50.40.70.50.60.20.3
Total zone transitions, NPP test0.71.11.51.1-1.0-1.2-0.9-1.0-1.0-1.2-1.0-1.1-1.1-1.0-1.1-1.0-0.8
Total locomotion distance, NPP test2.33.14.01.4-1.5-2.0-1.7-1.7-1.7-1.8-1.7-1.9-1.8-1.7-1.9-1.8-2.0
Locomotion velocity, NPP test2.73.84.81.8-1.8-2.2-1.9-1.9-1.9-2.0-1.9-2.1-2.0-1.9-2.1-1.9-1.8
Intraocular pressure1.11.63.51.0-0.9-0.9-1.6-1.5-1.3-0.4-1.5-1.2-1.2-1.6-1.3-0.9-1.9
Delta distance traveled before/after self-admin0.90.91.51.2-1.2-1.0-1.0-0.9-0.9-0.9-0.9-1.1-0.8-0.9-0.7-1.10.4
Delta ambulatory time before/after self-admin0.70.81.31.0-1.1-1.0-0.9-0.9-0.9-1.0-0.8-1.1-0.8-0.8-0.7-1.10.4
Parametrial fat weight19.846.760.6-7.87.77.27.17.17.17.06.96.87.06.86.96.60.9
Pavlov. Cond. lever latency0.60.84.5-1.71.30.30.60.60.60.40.40.10.50.40.40.4-2.1
Pavlov. Cond. magazine entry latency0.70.95.0-0.10.31.10.60.60.60.90.71.20.80.60.80.82.2
Pavlov. Cond. change in total contacts0.90.97.51.5-1.3-0.1-0.6-0.5-0.5-0.2-0.30.2-0.4-0.3-0.2-0.22.7
Pavlov. Cond. index score0.60.77.81.0-0.70.4-0.00.00.00.30.20.60.20.20.30.42.8
Pavlov. Cond. latency score0.60.86.91.5-1.10.0-0.4-0.4-0.4-0.1-0.20.2-0.2-0.2-0.1-0.12.6
Pavlov. Cond. lever contacts0.40.54.61.0-0.60.3-0.1-0.0-0.10.20.10.50.10.10.10.22.1
Pavlov. Cond. magazine entry number0.81.05.9-0.0-0.2-1.2-0.6-0.7-0.7-1.0-0.8-1.2-0.8-0.7-0.9-0.9-2.4
Pavlov. Cond. intertrial magazine entries2.73.38.80.4-0.9-2.0-1.6-1.7-1.6-1.9-1.8-2.2-1.6-1.8-1.7-1.9-3.0
Pavlov. Cond. lever-magazine prob. diff.0.81.09.50.9-0.60.70.20.20.20.60.40.90.40.40.50.63.1
Pavlov. Cond. response bias0.81.06.80.20.11.10.60.60.60.90.81.20.80.70.90.92.6
Pavlov. Cond. lever latency4.56.17.62.7-2.7-2.4-2.6-2.6-2.6-2.6-2.6-2.4-2.6-2.5-2.5-2.5-0.6
Pavlov. Cond. magazine entry latency1.31.64.6-2.11.91.11.31.31.30.91.11.01.11.01.10.7-1.3
Pavlov. Cond. change in total contacts4.57.29.2-3.03.02.62.82.82.82.72.82.62.82.72.72.60.7
Pavlov. Cond. index score4.45.99.2-3.02.92.42.62.62.62.32.52.32.52.42.42.20.0
Pavlov. Cond. latency score3.64.87.0-2.72.62.12.32.32.32.12.22.12.32.22.21.90.2
Pavlov. Cond. lever contacts4.66.48.1-2.82.82.52.72.72.72.62.62.42.62.62.52.40.5
Pavlov. Cond. magazine entry number2.53.16.52.5-2.3-1.7-1.9-1.8-1.9-1.5-1.7-1.6-1.7-1.6-1.7-1.40.7
Pavlov. Cond. intertrial magazine entries0.61.03.01.7-1.4-0.8-1.0-1.0-1.0-0.6-0.9-0.9-0.9-0.8-0.8-0.70.3
Pavlov. Cond. lever-magazine prob. diff.5.16.89.6-3.13.02.62.82.82.82.52.72.52.72.62.62.40.3
Pavlov. Cond. response bias4.25.79.5-3.13.02.32.62.52.52.32.42.22.42.32.32.1-0.3
Time in closed arm before self-admin0.10.21.5-0.20.20.20.00.00.10.4-0.00.20.0-0.1-0.10.6-1.2
Time in closed arm after self-admin0.60.72.00.4-0.6-0.8-0.9-0.9-0.8-0.3-0.9-0.8-0.8-0.9-1.0-0.1-1.4
Time in open arm before self-admin0.20.32.80.3-0.2-0.10.10.1-0.0-0.50.1-0.10.00.30.1-0.61.7
Time in open arm after self-admin1.11.33.2-1.00.90.91.21.21.10.41.21.21.11.21.30.21.8
Bone: periosteal estimation1.02.13.6-1.91.91.41.61.51.51.31.51.41.31.31.31.1-1.1
Bone: periosteal perimeter0.20.31.1-0.90.70.20.50.50.40.30.40.20.40.30.3-0.0-1.1
Bone: post-yield work0.00.10.2-0.4-0.0-0.2-0.2-0.3-0.2-0.2-0.2-0.2-0.2-0.4-0.2-0.3-0.4
Progressive ratio test 1 active lever presses0.20.30.7-0.80.70.40.60.60.60.10.60.30.50.60.40.4-0.2
Progressive ratio test 1 breakpoint0.30.40.8-0.90.80.50.70.70.70.20.70.40.60.70.50.5-0.2
Progressive ratio test 1 inactive lever presses0.40.63.4-0.50.1-0.7-0.5-0.5-0.4-0.9-0.7-1.0-0.5-0.6-0.6-0.8-1.8
Progressive ratio test 2 active lever presses0.10.10.5-0.70.50.00.40.40.3-0.20.2-0.10.20.40.2-0.0-0.3
Progressive ratio test 2 breakpoint0.10.10.6-0.80.5-0.00.40.40.3-0.30.2-0.10.20.40.2-0.0-0.3
Progressive ratio test 2 inactive lever presses0.30.53.4-1.31.00.20.30.30.4-0.10.1-0.40.30.30.2-0.2-1.9
Incentive Sensitization - Responses0.10.20.6-0.30.0-0.5-0.2-0.2-0.2-0.5-0.4-0.8-0.3-0.2-0.3-0.5-0.6
Incentive Sensitization - Breakpoint0.10.10.5-0.50.2-0.5-0.1-0.1-0.1-0.5-0.3-0.7-0.2-0.1-0.2-0.5-0.6
Sum of active levers in priming session hrs 5-60.70.60.90.5-0.6-1.0-0.9-0.9-0.8-0.7-0.9-0.9-0.8-0.9-0.8-0.5-0.6
Progressive ratio2.23.44.41.0-1.5-2.0-2.0-2.0-1.7-1.6-2.1-2.0-1.7-2.0-1.9-1.9-2.1
Food seeking constrained by brief footshock1.72.13.11.6-1.7-1.8-1.3-1.3-1.3-1.6-1.3-1.3-1.4-1.3-1.3-1.61.0
Seeking ratio, punishment vs. effort1.42.06.7-0.70.91.21.51.51.30.91.61.41.21.51.41.22.6
Retroperitoneal fat weight23.198.7118.3-10.610.910.610.210.210.310.710.110.010.210.09.910.01.5
Reaction time number correct1.32.46.01.4-1.3-1.2-1.6-1.6-1.6-0.9-1.6-1.6-1.4-1.6-1.6-1.6-2.5
Reaction time mean minus median0.82.14.5-2.11.81.21.51.51.61.11.41.31.51.31.51.00.8
Reaction time mean minus median AUC0.71.83.7-1.91.71.11.41.41.51.11.31.21.41.21.30.80.3
Reaction time num false alarms2.02.84.42.1-1.8-1.6-1.6-1.6-1.8-1.6-1.6-1.5-1.8-1.6-1.9-1.6-1.2
Reaction time num false alarms AUC1.52.44.02.0-1.6-1.5-1.4-1.4-1.6-1.5-1.5-1.4-1.7-1.5-1.7-1.4-0.9
Reaction time trials correct on left1.32.46.01.4-1.3-1.2-1.6-1.6-1.6-0.9-1.6-1.6-1.4-1.6-1.6-1.6-2.5
Reaction time trials on left1.32.46.31.4-1.3-1.1-1.6-1.5-1.5-0.9-1.5-1.6-1.4-1.6-1.6-1.6-2.5
Reaction time mean3.04.77.7-2.82.62.02.32.32.42.12.21.92.32.12.22.00.2
Reaction time mean AUC2.54.05.8-2.42.41.92.12.12.22.02.01.82.12.02.01.90.1
Median of all reaction times3.04.26.2-2.52.41.92.22.22.22.12.11.82.12.12.02.0-0.1
Reaction time omissions0.40.61.6-1.31.00.80.60.70.81.00.70.50.80.50.80.5-0.4
Reaction time false alarm rate0.50.61.21.1-0.9-0.9-0.7-0.7-0.8-1.0-0.7-0.7-0.9-0.7-0.9-0.60.1
Reaction time premature initiation rate0.10.21.20.0-0.1-0.6-0.1-0.1-0.2-0.5-0.2-0.4-0.3-0.1-0.4-0.2-1.1
Reaction time premature initiations0.81.45.60.8-0.8-1.2-1.0-1.0-1.1-1.0-1.1-1.2-1.1-1.0-1.3-1.1-2.4
Std. dev. reaction times1.73.25.9-2.42.21.61.91.91.91.51.81.71.91.71.81.50.9
Reaction time trials completed1.32.46.31.4-1.3-1.1-1.6-1.5-1.5-0.9-1.5-1.6-1.4-1.6-1.6-1.6-2.5
Reaction time trials AUC1.42.68.31.3-1.3-1.2-1.6-1.6-1.6-0.9-1.6-1.7-1.5-1.6-1.6-1.6-2.9
Run reversals in cocaine runway, females2.72.73.3-1.61.71.71.81.71.71.81.81.61.81.81.81.50.4
Run reversals in cocaine runway, males3.13.15.5-1.41.41.62.02.01.81.11.91.91.52.01.71.42.3
Latency to leave start box in cocaine runway0.80.94.10.7-0.6-0.5-1.1-1.0-0.9-0.1-1.0-0.8-0.8-1.2-0.8-0.4-2.0
Latency to leave start box in cocaine runway, F0.30.44.4-0.10.20.3-0.2-0.1-0.10.6-0.2-0.1-0.1-0.3-0.10.2-2.1
Latency to leave start box in cocaine runway, M2.11.92.91.3-1.4-1.3-1.6-1.6-1.5-1.1-1.6-1.4-1.4-1.7-1.3-1.0-1.1
Std. dev. time between licks in bursts0.60.81.31.1-1.0-0.9-0.9-0.9-0.9-0.9-0.8-0.7-0.9-0.8-0.8-1.00.1
Total sessions with >9 infusions0.20.20.9-0.90.60.00.60.50.5-0.50.40.10.30.50.4-0.20.3
Short access day 1 total inactive lever presses1.01.35.70.2-0.5-1.0-1.0-1.1-1.0-1.0-1.2-1.2-1.1-1.1-1.2-1.0-2.4
Short access day 10 total inactive lever presses0.40.97.9-0.30.1-0.3-0.8-0.8-0.6-0.2-0.9-0.8-0.7-0.9-0.7-0.5-2.8
Short access day 1 total infusions1.11.43.40.7-1.0-1.4-1.0-1.0-1.1-1.9-1.1-1.2-1.2-1.0-1.1-1.6-0.7
Short access day 10 total infusions0.10.10.6-0.50.40.10.20.20.2-0.20.1-0.10.10.10.1-0.1-0.8
Short access total infusions0.10.10.6-0.80.5-0.00.40.30.3-0.50.2-0.00.20.30.2-0.2-0.1
Short access day 1 locomotion0.00.10.4-0.20.1-0.10.20.20.0-0.60.1-0.1-0.00.20.0-0.40.3
Short access day 10 total locomotion0.30.61.40.7-0.7-0.8-0.7-0.6-0.8-1.2-0.7-0.9-0.9-0.6-0.8-1.0-0.5
Short access total locomotion0.20.20.90.6-0.5-0.4-0.00.0-0.3-1.0-0.1-0.3-0.40.1-0.3-0.60.7
One hour access (0.3 mA shock)0.70.92.0-0.1-0.5-1.2-0.9-0.9-0.7-1.4-1.0-1.3-0.8-1.0-0.7-1.1-0.2
Compulsive drug intake2.63.14.61.4-1.8-1.9-2.1-2.1-1.7-1.8-2.1-1.9-1.7-2.1-1.5-1.40.4
One hour access (shock baseline)0.30.51.1-1.00.90.61.00.90.80.20.80.60.60.90.60.30.1
Social response proportion4.55.16.8-2.12.52.52.22.22.32.62.22.32.42.12.42.40.7
Social responses0.60.71.1-0.40.81.01.01.00.81.11.01.00.80.90.70.9-0.2
Social time1.82.43.4-0.91.41.81.71.71.51.71.71.81.51.81.51.50.7
Soleus weight0.00.10.7-0.20.30.20.00.10.0-0.00.10.3-0.0-0.10.10.1-0.8
Bone: stiffness0.10.10.2-0.50.40.40.40.40.30.30.40.50.20.40.20.0-0.4
Tibialis anterior weight0.62.13.4-1.81.71.61.41.41.51.31.41.61.41.31.51.30.5
Time to tail flick, vehicle, before self-admin1.21.22.6-1.61.41.10.70.70.91.50.70.71.00.50.71.5-1.6
Time to tail flick, vehicle, after self-admin0.10.10.40.00.20.30.20.10.10.30.10.6-0.00.2-0.10.6-0.5
Time to tail flick, test, before self-admin0.30.30.9-0.1-0.4-0.8-0.4-0.4-0.4-1.0-0.6-0.4-0.6-0.4-0.5-0.51.0
Time to tail flick, test, after self-admin1.31.35.6-0.0-0.4-1.1-0.9-1.0-0.9-1.1-1.1-1.2-1.0-1.1-1.2-1.1-2.4
Delta time to tail flick, vehicle, before/after SA0.70.61.21.1-0.9-0.9-0.6-0.7-0.8-1.1-0.7-0.5-0.9-0.6-0.8-0.8-0.0
Delta time to tail flick, test, before/after SA0.40.44.80.1-0.0-0.1-0.3-0.3-0.30.0-0.3-0.5-0.2-0.4-0.4-0.4-2.2
Tibia length2.77.49.0-2.83.02.82.92.92.82.82.82.82.72.82.62.80.7
Ambulatory time before self-admin0.71.11.8-0.70.91.01.21.21.10.81.21.31.11.21.00.70.9
Ambulatory time after self-admin0.20.20.90.8-0.7-0.3-0.2-0.1-0.2-0.3-0.1-0.1-0.2-0.1-0.1-0.60.9
Bone: tissue strength0.80.81.0-0.90.90.80.91.00.90.60.90.90.91.01.00.70.8
Total heroin consumption0.30.41.7-0.1-0.1-0.6-0.5-0.6-0.5-0.5-0.6-0.5-0.5-0.7-0.5-0.4-1.3
Bone: trabecular number0.10.10.50.7-0.5-0.2-0.3-0.3-0.3-0.2-0.2-0.2-0.3-0.3-0.2-0.30.5
Bone: trabecular spacing1.52.03.2-1.81.61.41.51.51.51.21.41.51.41.51.41.20.3
Bone: trabecular thickness0.10.10.40.5-0.4-0.0-0.1-0.2-0.20.1-0.1-0.0-0.1-0.1-0.10.20.6
Bone: trabecular tissue density0.60.81.5-0.50.60.71.01.01.00.91.10.90.91.11.00.91.2
Water consumed over 24 hours0.10.21.8-0.40.4-0.20.00.0-0.0-0.2-0.1-0.3-0.1-0.1-0.3-0.2-1.3
Number of responses in last shaping day1.41.52.60.5-0.8-1.4-1.2-1.2-1.1-1.5-1.3-1.6-1.1-1.2-1.2-1.3-1.5