Hub : Genes

Dpysl5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Dpysl5 0.35 0.16 0.0e+00 0.34 0.34 0.34 0.34 2.7e-38 1.5e-38 2.6e-38 1.6e-38
2 NAcc mRNA stability Dpysl5 0.06 0.04 7.0e-09 0.07 0.08 0.07 0.07 2.4e-08 3.6e-09 1.7e-08 1.2e-08
3 pVTA mRNA stability Dpysl5 0.09 0.08 4.9e-03 0.04 0.03 0.02 0.05 1.2e-02 1.3e-02 5.1e-02 3.2e-03
4 PL mRNA stability Dpysl5 0.05 0.04 1.2e-06 0.05 0.05 0.05 0.05 8.6e-06 2.9e-06 4.7e-06 3.6e-06
5 OFC gene expression Dpysl5 0.27 0.14 5.6e-07 0.24 0.24 0.25 0.24 2.6e-06 2.3e-06 1.4e-06 1.8e-06
6 Brain gene expression Dpysl5 0.04 0.03 7.1e-05 0.04 0.04 0.03 0.03 8.1e-05 2.0e-04 1.5e-03 4.8e-04
7 Eye gene expression Dpysl5 0.91 0.03 8.8e-10 0.36 0.28 0.33 0.32 1.5e-06 3.5e-05 5.6e-06 8.1e-06
8 Liver mRNA stability Dpysl5 0.09 0.07 3.2e-08 0.07 0.06 0.06 0.06 3.3e-08 2.6e-07 1.6e-07 1.3e-07
9 PL gene expression Dpysl5 0.03 0.02 2.7e-03 0.02 0.02 0.02 0.02 3.2e-03 3.2e-03 5.2e-03 4.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density4.16.89.12.8-2.7-3.0-2.8-2.6-2.02.4-2.4-2.6
Area under the delay curve0.10.10.3-0.10.20.00.10.20.3-0.50.60.2
BMI with tail1.13.67.7-1.91.91.11.51.82.8-2.21.91.3
BMI without tail0.20.40.9-0.70.60.40.50.60.9-0.90.50.5
Body weight2.19.011.5-3.03.02.72.82.93.4-3.33.12.8
Weight adjusted by age0.10.10.3-0.20.10.0-0.1-0.0-0.20.5-0.5-0.2
Bone surface1.62.85.21.7-1.7-2.3-1.8-1.5-0.61.6-1.6-1.6
Bone volume2.03.35.32.0-2.0-2.3-2.0-1.8-1.31.6-1.6-1.7
Breakpoint value in progressive ratio session1.01.11.91.2-1.2-1.0-1.3-1.4-0.50.9-0.9-1.1
Number of licking bursts0.30.31.5-0.50.5-0.10.30.51.2-0.20.30.5
Context. condit. distance diff. score0.00.00.30.1-0.10.00.00.0-0.6-0.0-0.10.1
Locomotion velocity, session 10.40.41.9-0.40.4-0.00.30.41.4-0.80.60.2
Locomotion distance, session 11.01.32.71.1-1.1-1.6-1.2-0.9-0.11.2-1.1-1.0
Locomotion velocity, session 20.20.20.5-0.40.50.50.60.60.3-0.40.40.7
Locomotion distance, session 20.00.00.2-0.10.1-0.10.10.30.50.1-0.00.1
Locomotion velocity, session 30.80.91.80.7-0.8-0.9-0.9-0.8-0.81.3-1.3-1.1
Locomotion distance, session 30.60.61.20.6-0.6-1.1-0.8-0.5-0.10.9-1.0-0.9
Stereotopy head waving bouts, day 32.42.84.41.7-1.7-1.5-1.7-1.7-2.11.4-1.5-1.7
Stereotopy head waving duration, day 30.40.41.20.6-0.7-0.4-0.6-0.7-1.10.4-0.5-0.7
Locomotion velocity, session 70.60.71.30.7-0.7-1.2-0.9-0.6-0.50.7-0.8-1.1
Locomotion distance, session 70.10.21.0-0.30.3-0.30.00.41.0-0.1-0.1-0.1
Stereotopy head waving bouts, day 70.00.10.3-0.10.10.10.10.1-0.6-0.10.20.1
Stereotopy head waving duration, day 70.60.71.70.8-0.8-0.6-0.7-0.8-1.30.7-0.6-0.8
Locomotion velocity, session 80.30.40.70.7-0.7-0.6-0.6-0.6-0.80.6-0.6-0.4
Locomotion distance, session 80.20.30.70.6-0.6-0.8-0.5-0.4-0.80.5-0.5-0.3
Degree of sensitization distance1.01.01.3-1.01.00.91.01.01.1-1.01.01.0
Degree of sensitization stereotypy0.20.20.3-0.50.50.50.50.50.0-0.40.50.5
Conditioned locomotion3.84.55.22.1-2.1-1.9-2.1-2.1-2.32.1-2.1-2.1
Cocaine response after cond. corrected0.30.31.00.7-0.7-1.0-0.7-0.7-0.3-0.10.1-0.4
Cocaine response after cond. not corrected1.01.12.11.2-1.1-1.4-1.2-1.1-0.90.5-0.5-0.8
Cocaine response before conditioning2.02.53.91.5-1.5-1.2-1.4-1.4-1.92.0-1.9-1.3
Saline control response0.91.11.41.2-1.1-1.1-1.0-1.1-1.01.1-1.1-0.7
Bone: connectivity density3.65.78.12.5-2.5-2.8-2.6-2.4-1.22.4-2.4-2.5
Bone: cortical apparent density0.30.41.30.5-0.4-0.6-0.5-0.3-0.11.1-1.0-0.6
Bone: cortical area0.10.10.50.2-0.2-0.7-0.3-0.00.50.2-0.3-0.1
Bone: cortical porosity2.52.74.81.7-1.7-1.3-1.6-1.7-2.21.5-1.5-1.6
Bone: cortical porosity1.92.03.71.5-1.5-1.2-1.4-1.5-1.91.1-1.2-1.4
Bone: cortical thickness0.20.30.6-0.50.50.10.50.70.6-0.50.50.8
Bone: cortical thickness1.11.22.11.1-1.1-1.4-1.2-1.0-0.71.2-1.2-0.9
Bone: cortical tissue density0.20.31.00.4-0.3-0.5-0.4-0.20.11.0-0.9-0.5
Condit. Reinf. active minus inactive responses1.11.32.3-1.21.10.91.01.11.5-1.21.30.8
Condit. Reinf. active-inactive response ratio0.91.01.8-1.11.11.00.90.91.4-0.90.90.6
Condit. Reinf. active responses0.10.10.10.0-0.0-0.4-0.20.00.3-0.30.4-0.2
Condit. Reinf. inactive responses1.01.22.21.3-1.2-1.5-1.2-1.0-1.10.7-0.6-1.1
Incentive salience index mean0.10.10.4-0.20.2-0.00.10.10.6-0.50.5-0.1
Condit. Reinf. lever presses0.30.40.60.8-0.7-0.8-0.7-0.7-0.70.1-0.1-0.6
Condit. Reinf. active minus inactive responses3.94.96.02.0-2.0-2.1-2.2-2.1-2.02.5-2.4-2.4
Condit. Reinf. active-inactive response ratio0.91.01.11.0-1.0-1.0-1.0-1.0-1.10.9-0.8-1.0
Condit. Reinf. active responses3.24.55.91.8-1.9-1.9-2.1-2.1-2.02.4-2.3-2.4
Condit. Reinf. inactive responses1.62.02.81.2-1.2-1.4-1.4-1.3-1.31.7-1.6-1.7
Condit. Reinf. lever presses2.12.94.11.6-1.5-1.6-1.6-1.5-1.92.0-1.9-1.5
Condit. Reinf. lever reinforcers received3.04.25.61.8-1.8-1.8-2.0-1.9-1.92.4-2.3-2.4
Conditioned reinforcement - actives2.62.63.31.8-1.7-1.4-1.6-1.8-1.81.6-1.5-1.4
Conditioned reinforcement - inactives3.53.94.82.2-2.2-1.9-2.0-2.1-1.71.9-1.9-1.8
Conditioned locomotion1.61.94.11.4-1.4-0.6-1.2-1.5-2.01.5-1.3-1.2
Patch foraging indifference point 0 sec0.50.81.3-0.90.80.90.80.71.1-1.00.80.7
Patch foraging indifference point AUC1.41.63.71.1-1.1-1.9-1.4-1.00.01.0-1.3-1.5
Delay disc. indifference point, 0s delay4.14.56.5-1.91.91.92.02.01.7-2.52.62.4
Delay disc. indifference point, 16s delay0.00.00.10.0-0.0-0.3-0.10.0-0.10.2-0.1-0.3
Delay disc. indifference point, 2s delay0.40.50.8-0.60.60.50.60.70.4-0.80.90.9
Delay disc. indifference point, 24s delay1.00.91.31.1-1.1-0.8-0.9-1.0-1.11.0-0.8-0.6
Delay disc. indifference point, 4s delay0.20.20.7-0.20.3-0.10.20.30.6-0.60.80.3
Delay disc. indifference point, 8s delay0.00.00.10.1-0.0-0.0-0.1-0.0-0.1-0.20.20.0
Indifference point function ln k0.20.31.90.5-0.40.2-0.1-0.5-1.40.20.00.2
Indifference point function log k0.20.31.90.5-0.40.2-0.1-0.5-1.40.20.00.2
Patch foraging total patch changes 0 sec0.50.71.4-0.90.80.80.70.71.2-1.00.70.7
Patch foraging total patch changes 12 sec0.91.21.9-1.21.11.01.11.11.4-1.10.91.0
Patch foraging total patch changes 18 sec0.20.31.6-0.50.50.00.30.41.3-0.40.30.2
Patch foraging total patch changes 24 sec0.81.01.4-1.11.10.81.01.11.2-0.80.71.0
Patch foraging total patch changes 6 sec0.30.51.8-0.80.70.20.40.81.3-0.70.40.2
Patch foraging time to switch 0 sec0.00.10.2-0.30.30.20.20.10.40.2-0.20.0
Patch foraging water rate 0 sec0.20.31.20.6-0.6-0.2-0.3-0.4-1.10.2-0.2-0.2
Patch foraging water rate 12 sec0.71.12.3-1.11.11.51.41.30.2-0.30.11.3
Patch foraging water rate 18 sec0.20.31.2-0.10.20.80.60.3-1.1-0.10.10.7
Patch foraging water rate 24 sec1.11.53.0-1.31.31.71.41.30.6-0.90.91.3
Patch foraging water rate 6 sec0.60.92.3-0.80.81.21.20.9-0.0-0.40.71.5
Seeking ratio, delayed vs. immediate footshock0.00.00.10.0-0.1-0.3-0.10.0-0.00.00.1-0.3
Distance traveled before self-admin0.10.10.70.2-0.2-0.1-0.1-0.2-0.80.2-0.10.2
Distance traveled after self-admin1.01.11.9-0.90.90.81.00.90.7-1.31.41.3
Extensor digitorum longus weight3.915.518.03.9-3.9-4.2-4.1-3.8-3.24.0-4.0-4.1
Bone: elastic displacement1.11.31.91.2-1.2-0.8-1.1-1.3-1.41.0-0.9-1.1
Bone: elastic work0.81.01.31.0-1.1-1.1-1.1-1.1-0.80.9-0.9-1.2
Bone: endosteal estimation0.20.50.90.7-0.8-1.0-0.8-0.60.30.7-0.8-0.8
Bone: endosteal perimeter0.10.10.30.3-0.3-0.5-0.4-0.20.40.2-0.3-0.3
Epididymis fat weight14.333.437.9-6.26.15.95.85.95.4-5.75.55.4
Delta time in closed arm before/after self-admin0.20.21.2-0.40.40.20.30.31.1-0.40.10.5
Delta time in open arm before/after self-admin0.40.31.00.5-0.5-0.6-0.6-0.6-0.30.6-0.4-1.0
Diff in mean of infusions in LGA sessions0.10.20.30.4-0.4-0.4-0.5-0.50.00.2-0.2-0.6
Delay discount exponential model param0.00.00.1-0.20.10.30.20.1-0.00.2-0.30.0
Extinction: sum of active levers before priming0.30.30.60.6-0.6-0.5-0.6-0.50.20.6-0.7-0.7
Active lever presses in extinction session 60.90.91.41.0-1.1-0.6-1.1-1.2-0.80.9-0.8-1.0
Bone: final force0.10.10.30.2-0.1-0.5-0.2-0.00.50.3-0.4-0.1
Bone: final moment0.10.10.30.2-0.2-0.5-0.3-0.10.50.3-0.4-0.2
Food consumed during 24 hour testing period0.00.00.30.1-0.1-0.6-0.2-0.10.0-0.10.1-0.1
Glucose0.20.30.5-0.60.50.50.50.50.6-0.50.70.4
Heart weight8.111.414.9-3.43.53.63.73.52.5-2.83.33.9
Delay discount hyperbolic model param0.00.00.1-0.10.10.30.20.1-0.10.2-0.30.0
Intermittent access intake day 1-15 change0.50.51.00.8-0.8-0.7-0.5-0.7-1.00.7-0.6-0.2
Intermittent access intake escalation0.20.20.40.6-0.5-0.4-0.3-0.5-0.60.4-0.30.1
Intermittent access intake escalation 20.20.20.4-0.30.3-0.00.40.40.4-0.40.40.6
Intermitt. access day 1 inactive lever presses0.20.20.50.3-0.3-0.2-0.3-0.3-0.30.6-0.7-0.4
Intermitt. access day 15 inactive lever presses7.07.711.12.7-2.7-3.3-3.0-2.6-1.92.7-2.8-3.1
Intermitt. access escalation Index0.90.82.5-0.80.80.20.60.81.6-1.00.90.5
Intermittent access day 1 total infusions5.36.16.52.5-2.5-2.4-2.5-2.4-2.52.4-2.4-2.6
Intermittent access day 15 total infusions3.13.44.12.0-2.0-1.9-1.8-1.9-1.91.8-1.7-1.5
Intermittent access terminal intake (last 3 days)2.83.13.71.9-1.8-1.7-1.7-1.7-1.91.8-1.7-1.4
Intermittent access total infusions3.23.64.52.0-2.0-1.5-1.9-2.0-2.11.9-1.9-1.6
Intermittent access day 1 locomotion2.32.42.61.6-1.6-1.5-1.6-1.5-1.31.6-1.6-1.6
Intermittent access day 15 total locomotion0.80.91.31.0-0.9-0.9-1.0-0.9-0.71.1-1.1-0.9
Intermittent access total locomotion0.60.71.10.9-0.9-0.6-0.8-0.9-0.71.0-1.0-0.8
Intermittent access standard deviation0.40.50.60.7-0.7-0.5-0.6-0.7-0.60.8-0.8-0.5
Left kidney weight0.00.10.70.3-0.30.20.1-0.2-0.80.3-0.10.5
Right kidney weight1.02.74.7-1.51.62.01.81.60.9-1.21.72.2
Cocaine induced anxiety0.30.30.70.6-0.6-0.9-0.6-0.50.10.5-0.7-0.6
Post-drug Anxiety1.41.62.4-1.11.20.51.21.31.6-1.41.31.3
Baseline Anxiety1.92.13.2-1.41.41.21.51.50.8-1.61.81.4
Tail length0.00.00.20.0-0.00.30.2-0.0-0.4-0.10.00.4
Length with tail1.03.65.2-1.71.82.22.01.71.3-1.72.02.3
Length without tail0.71.62.4-1.11.11.31.31.21.1-1.21.51.4
Times rat made contact with spout1.21.42.01.2-1.2-1.4-1.2-1.1-1.31.1-1.0-1.0
Lifetime Intake4.34.85.62.3-2.3-1.8-2.2-2.4-2.32.2-2.1-2.0
Liver weight, left1.52.53.5-1.51.51.31.51.51.5-1.91.91.6
Liver weight, right8.814.716.2-3.83.93.74.04.03.6-3.73.84.0
Locomotor activity0.81.33.3-0.90.90.80.80.91.8-1.21.41.0
Locomotor testing distance0.10.10.9-0.10.0-0.2-0.1-0.01.0-0.00.2-0.2
Locomotor testing rearing0.81.32.11.1-1.2-0.9-1.3-1.4-0.21.1-1.2-1.5
Locomotion in novel chamber0.50.70.9-0.90.90.90.80.90.7-0.70.80.6
Locomotion in novel chamber post-restriction2.42.95.6-1.91.81.71.61.72.4-1.41.31.4
Fecal boli incidents, locomotor time 10.70.81.71.0-1.0-0.6-0.7-0.9-1.30.8-0.8-0.5
Change in fecal boli incidents, locomotor task5.24.96.3-2.22.12.22.12.12.2-2.52.52.0
Time >=10cm from walls, locomotor time 10.00.00.2-0.00.00.50.20.1-0.2-0.10.10.1
Bouts of movement, locomotor time 11.61.82.81.1-1.1-1.7-1.3-1.0-1.41.6-1.5-1.3
Total resting periods, locomotor time 11.92.13.31.2-1.2-1.8-1.5-1.1-1.61.6-1.4-1.4
Rest time, locomotor task time 10.20.21.30.3-0.3-0.3-0.4-0.4-1.10.3-0.2-0.3
Distance moved, locomotor task time 11.21.32.1-1.01.01.31.21.01.4-1.21.01.0
Vertical activity count, locomotor time 10.80.81.1-0.80.80.90.90.91.0-1.00.90.8
Time >=10cm from walls, locomotor time 20.50.51.00.8-0.8-0.4-0.6-0.7-1.00.5-0.6-0.5
Bouts of movement, locomotor time 20.20.20.5-0.60.60.20.50.70.10.20.00.7
Total resting periods, locomotor time 20.10.10.2-0.40.4-0.10.30.5-0.10.4-0.20.4
Rest time, locomotor task time 20.80.91.70.8-0.8-1.3-1.0-0.8-1.20.8-0.7-0.9
Distance moved, locomotor task time 20.50.61.1-0.60.61.10.80.60.9-1.00.80.6
Vertical activity count, locomotor time 20.10.20.5-0.20.20.70.40.20.1-0.60.50.4
Light reinforcement 12.44.48.32.1-2.1-2.9-2.3-2.0-1.21.6-1.8-2.4
Light reinforcement 22.43.26.01.8-1.8-2.4-1.9-1.6-1.41.5-1.4-1.9
Bone: marrow area0.30.60.90.7-0.8-1.0-0.9-0.70.20.7-0.8-0.8
Bone: maximum diameter0.40.71.70.7-0.8-1.3-0.9-0.60.30.7-0.9-0.9
Bone: maximum force0.00.00.4-0.00.0-0.2-0.00.10.60.0-0.10.1
Bone: maximum moment0.00.00.30.1-0.1-0.3-0.1-0.00.50.1-0.2-0.1
Mean time between licks in bursts2.73.95.0-2.02.01.92.01.91.8-1.91.92.2
Mean num. licks in bursts0.50.62.50.9-0.9-0.4-0.7-0.8-1.60.3-0.4-0.6
Cd content in liver0.10.10.7-0.20.2-0.10.10.40.8-0.40.30.1
Co content in liver5.05.87.42.6-2.6-2.4-2.5-2.5-2.72.1-2.1-2.2
Cu content in liver0.00.00.10.2-0.3-0.1-0.2-0.30.20.1-0.1-0.3
Fe content in liver0.10.10.20.1-0.20.1-0.2-0.40.50.4-0.3-0.3
K content in liver0.80.82.9-0.80.80.10.60.81.7-0.91.00.7
Mg content in liver1.21.24.0-0.90.90.40.70.92.0-1.21.20.7
Mn content in liver0.40.40.80.4-0.4-0.9-0.7-0.60.20.8-0.7-0.9
Na content in liver0.60.61.01.0-1.0-0.8-0.8-1.0-1.00.2-0.2-0.6
Rb content in liver0.20.21.5-0.40.30.10.20.31.2-0.30.30.1
Se content in liver0.50.62.9-0.80.70.50.60.61.7-0.30.50.4
Sr content in liver0.40.41.1-0.40.40.30.50.50.0-1.01.00.6
Zn content in liver1.71.92.5-1.41.41.21.31.51.6-1.31.41.3
Bone: minimum diameter0.30.62.0-0.70.60.30.50.81.4-0.70.60.5
Time in familiar zone, hab. session 11.11.02.2-0.90.90.80.80.91.5-1.11.10.9
Time in novel zone, hab. session 10.20.20.8-0.60.50.90.50.5-0.10.0-0.00.2
Total zone transitions, hab. session 10.10.10.10.3-0.3-0.3-0.3-0.1-0.20.4-0.3-0.1
Total locomotion distance, hab. session 10.30.41.60.7-0.6-0.5-0.5-0.5-1.30.4-0.4-0.4
Locomotion velocity, hab. session 11.01.53.11.3-1.3-1.2-1.2-1.1-1.71.0-0.9-0.9
Time in familiar zone, hab. session 20.00.00.3-0.20.2-0.20.10.10.5-0.00.10.2
Time in novel zone, hab. session 20.30.30.7-0.50.50.90.60.50.3-0.50.40.4
Total zone transitions, hab. session 20.00.10.3-0.10.1-0.3-0.00.20.50.2-0.00.1
Total locomotion distance, hab. session 20.00.10.30.1-0.1-0.5-0.20.10.20.3-0.3-0.1
Locomotion velocity, hab. session 20.10.20.50.3-0.3-0.7-0.4-0.2-0.00.5-0.5-0.3
Novel to familiar place preference ratio1.01.01.3-1.01.11.11.11.00.2-1.11.01.1
Novelty place preference1.51.51.9-1.31.31.41.41.30.5-1.31.21.3
Time in novel zone, NPP test1.61.62.2-1.31.31.51.41.30.5-1.31.31.3
Total zone transitions, NPP test1.21.72.31.3-1.3-1.4-1.3-1.2-0.71.5-1.5-1.2
Total locomotion distance, NPP test1.82.42.91.6-1.6-1.7-1.6-1.5-1.21.6-1.7-1.5
Locomotion velocity, NPP test2.63.74.82.0-2.0-2.2-2.0-1.9-1.52.0-2.0-1.9
Intraocular pressure6.49.010.0-3.03.03.03.02.93.2-2.92.83.1
Delta distance traveled before/after self-admin1.71.82.4-1.41.41.01.31.41.6-1.51.51.2
Delta ambulatory time before/after self-admin0.40.50.8-0.60.60.30.60.70.8-0.90.90.6
Parametrial fat weight7.314.216.5-4.04.03.23.84.13.4-3.73.83.8
Pavlov. Cond. lever latency1.21.52.3-1.21.21.51.31.20.5-1.21.21.3
Pavlov. Cond. magazine entry latency0.00.00.1-0.0-0.0-0.2-0.1-0.00.30.3-0.1-0.0
Pavlov. Cond. change in total contacts0.00.00.00.1-0.1-0.2-0.1-0.1-0.00.1-0.1-0.1
Pavlov. Cond. index score0.40.51.00.6-0.6-1.0-0.7-0.6-0.00.7-0.7-0.6
Pavlov. Cond. latency score0.30.40.90.6-0.6-1.0-0.7-0.50.20.7-0.7-0.6
Pavlov. Cond. lever contacts0.70.81.20.9-0.9-1.1-0.9-0.9-0.50.9-0.9-0.9
Pavlov. Cond. magazine entry number0.20.30.6-0.50.50.80.60.50.0-0.60.60.6
Pavlov. Cond. intertrial magazine entries1.31.62.21.4-1.4-1.1-1.3-1.4-1.51.0-1.1-1.2
Pavlov. Cond. lever-magazine prob. diff.1.01.31.91.1-1.1-1.4-1.2-1.1-0.61.2-1.2-1.1
Pavlov. Cond. response bias1.31.51.81.3-1.3-1.3-1.2-1.3-1.01.3-1.2-1.2
Pavlov. Cond. lever latency1.62.12.7-1.51.41.61.51.41.6-1.41.31.4
Pavlov. Cond. magazine entry latency0.20.30.60.4-0.4-0.7-0.5-0.3-0.20.7-0.7-0.4
Pavlov. Cond. change in total contacts0.50.61.00.7-0.6-1.0-0.8-0.6-0.81.0-0.9-0.7
Pavlov. Cond. index score1.01.31.91.1-1.0-1.3-1.1-0.9-1.11.4-1.3-1.0
Pavlov. Cond. latency score1.11.32.11.1-1.0-1.3-1.1-0.9-1.11.4-1.4-1.0
Pavlov. Cond. lever contacts0.70.91.30.9-0.9-1.1-0.9-0.8-1.11.1-1.0-0.7
Pavlov. Cond. magazine entry number0.10.10.3-0.20.10.50.30.10.1-0.40.40.2
Pavlov. Cond. intertrial magazine entries3.24.15.0-2.12.12.22.12.11.9-1.92.01.8
Pavlov. Cond. lever-magazine prob. diff.0.70.91.40.8-0.8-1.1-0.9-0.7-0.81.2-1.1-0.8
Pavlov. Cond. response bias1.21.72.51.3-1.2-1.6-1.3-1.1-1.31.4-1.3-1.1
Time in closed arm before self-admin0.30.30.6-0.60.60.70.60.50.5-0.40.40.8
Time in closed arm after self-admin1.01.11.5-1.11.11.21.00.91.2-0.80.61.2
Time in open arm before self-admin0.00.00.1-0.20.20.10.30.30.1-0.20.00.2
Time in open arm after self-admin1.11.32.21.1-1.1-1.5-1.2-1.0-0.61.0-1.0-1.4
Bone: periosteal estimation0.30.61.30.8-0.8-1.1-0.9-0.60.20.7-0.8-0.7
Bone: periosteal perimeter0.00.10.30.2-0.2-0.6-0.3-0.00.40.1-0.2-0.1
Bone: post-yield work0.71.01.41.2-1.2-0.8-1.0-1.2-1.10.8-0.8-0.7
Progressive ratio test 1 active lever presses2.42.53.11.7-1.7-1.3-1.6-1.8-1.61.6-1.6-1.6
Progressive ratio test 1 breakpoint2.12.22.61.5-1.5-1.2-1.5-1.6-1.41.5-1.5-1.5
Progressive ratio test 1 inactive lever presses6.06.57.22.6-2.6-2.2-2.5-2.6-2.52.7-2.7-2.6
Progressive ratio test 2 active lever presses0.40.40.90.8-0.8-0.3-0.6-0.8-1.00.6-0.5-0.4
Progressive ratio test 2 breakpoint0.50.61.30.9-0.9-0.3-0.7-0.9-1.10.7-0.6-0.5
Progressive ratio test 2 inactive lever presses2.93.43.61.9-1.9-1.8-1.9-1.9-1.71.8-1.8-1.8
Incentive Sensitization - Responses0.00.00.10.2-0.30.20.0-0.1-0.2-0.20.30.3
Incentive Sensitization - Breakpoint0.10.10.30.0-0.00.40.20.1-0.1-0.40.50.5
Sum of active levers in priming session hrs 5-60.20.20.90.3-0.3-1.0-0.5-0.20.50.2-0.2-0.6
Progressive ratio0.10.20.30.3-0.4-0.1-0.4-0.4-0.30.5-0.5-0.5
Food seeking constrained by brief footshock7.28.910.73.2-3.3-2.2-2.9-3.2-3.03.1-3.0-2.9
Seeking ratio, punishment vs. effort0.60.71.01.0-1.0-0.7-0.8-0.9-0.90.8-0.9-0.7
Retroperitoneal fat weight22.874.988.9-9.49.48.58.89.18.4-8.08.08.1
Reaction time number correct0.40.50.80.7-0.7-0.9-0.8-0.6-0.80.7-0.7-0.8
Reaction time mean minus median0.00.10.40.1-0.10.1-0.1-0.2-0.60.1-0.1-0.2
Reaction time mean minus median AUC0.00.00.1-0.20.20.20.20.0-0.2-0.20.20.1
Reaction time num false alarms0.40.52.7-0.70.60.00.30.81.6-0.50.40.2
Reaction time num false alarms AUC0.40.52.6-0.70.6-0.10.30.81.6-0.60.50.2
Reaction time trials correct on left0.40.50.80.7-0.7-0.9-0.8-0.6-0.80.7-0.7-0.8
Reaction time trials on left0.40.60.80.8-0.7-0.9-0.8-0.6-0.80.7-0.7-0.8
Reaction time mean0.71.01.8-0.91.01.31.21.0-0.0-0.80.81.3
Reaction time mean AUC0.60.81.6-0.80.81.21.00.9-0.1-0.80.81.1
Median of all reaction times0.91.22.2-1.01.01.41.31.10.1-0.90.91.5
Reaction time omissions0.10.10.30.1-0.0-0.3-0.2-0.20.5-0.50.4-0.3
Reaction time false alarm rate0.71.03.4-1.11.00.40.71.11.8-0.90.90.6
Reaction time premature initiation rate0.20.20.5-0.50.50.50.50.50.4-0.30.30.7
Reaction time premature initiations0.00.00.1-0.10.10.00.10.10.00.1-0.20.2
Std. dev. reaction times0.20.20.5-0.60.60.70.60.5-0.1-0.30.30.5
Reaction time trials completed0.40.60.80.8-0.7-0.9-0.8-0.6-0.80.7-0.7-0.8
Reaction time trials AUC0.50.81.00.9-0.9-1.0-0.9-0.7-0.90.9-0.9-1.0
Run reversals in cocaine runway, females0.10.10.5-0.00.10.50.30.0-0.7-0.0-0.00.4
Run reversals in cocaine runway, males0.40.41.20.6-0.6-0.2-0.4-0.6-1.10.6-0.5-0.6
Latency to leave start box in cocaine runway0.70.71.10.9-0.8-1.1-0.8-0.8-1.10.6-0.5-0.9
Latency to leave start box in cocaine runway, F0.40.40.80.7-0.7-0.9-0.7-0.7-0.50.5-0.4-0.8
Latency to leave start box in cocaine runway, M1.51.52.61.2-1.2-1.2-1.1-1.2-1.61.1-1.0-1.2
Std. dev. time between licks in bursts0.50.61.6-0.70.70.10.60.81.3-0.80.80.8
Total sessions with >9 infusions4.34.76.42.3-2.3-1.5-2.2-2.5-2.22.2-2.1-2.1
Short access day 1 total inactive lever presses4.65.15.62.3-2.3-2.4-2.4-2.4-1.82.2-2.3-2.2
Short access day 10 total inactive lever presses0.60.71.30.6-0.6-1.0-0.9-0.6-0.30.9-1.1-1.2
Short access day 1 total infusions6.26.67.92.6-2.7-2.4-2.7-2.8-2.22.6-2.6-2.7
Short access day 10 total infusions4.95.56.52.5-2.5-2.0-2.4-2.6-2.42.2-2.2-2.1
Short access total infusions4.24.85.82.3-2.3-1.8-2.2-2.4-2.22.2-2.1-2.1
Short access day 1 locomotion8.99.611.33.0-3.0-2.8-3.0-3.1-3.13.4-3.3-3.1
Short access day 10 total locomotion1.21.31.71.1-1.1-1.0-1.0-1.0-1.31.3-1.3-1.0
Short access total locomotion1.41.52.41.2-1.2-0.8-1.1-1.2-1.61.3-1.2-1.0
One hour access (0.3 mA shock)1.92.32.81.7-1.6-1.5-1.6-1.7-1.21.4-1.5-1.3
Compulsive drug intake1.71.74.1-1.31.20.61.11.22.0-1.51.41.0
One hour access (shock baseline)3.23.85.22.1-2.0-1.4-1.9-2.1-2.32.0-1.9-1.6
Social response proportion0.30.31.1-0.10.20.50.30.1-0.5-1.01.10.5
Social responses0.10.20.6-0.30.30.10.30.40.2-0.80.60.4
Social time0.10.20.3-0.20.20.40.30.3-0.4-0.60.50.5
Soleus weight3.510.111.83.3-3.3-3.4-3.3-3.2-3.02.9-3.0-3.1
Bone: stiffness0.10.10.6-0.30.30.00.30.40.8-0.20.10.2
Tibialis anterior weight2.89.512.52.9-2.9-3.5-3.2-2.7-2.33.2-3.4-3.3
Time to tail flick, vehicle, before self-admin1.61.63.0-1.41.31.71.41.20.9-1.01.01.2
Time to tail flick, vehicle, after self-admin4.04.35.6-2.32.32.42.11.91.8-1.92.01.9
Time to tail flick, test, before self-admin0.80.80.90.9-0.9-0.7-0.8-1.0-0.90.9-0.9-0.8
Time to tail flick, test, after self-admin0.10.10.50.1-0.10.30.1-0.2-0.70.00.20.2
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.50.50.10.20.30.5-0.50.60.2
Delta time to tail flick, test, before/after SA0.50.51.20.8-0.8-0.6-0.6-0.7-1.10.5-0.4-0.4
Tibia length2.15.87.2-2.32.32.52.52.32.2-2.42.72.6
Ambulatory time before self-admin0.10.10.60.3-0.3-0.2-0.2-0.2-0.80.4-0.4-0.1
Ambulatory time after self-admin0.60.61.2-0.60.70.70.80.80.4-0.90.91.1
Bone: tissue strength0.90.91.3-0.91.01.01.00.90.4-1.11.10.9
Total heroin consumption2.12.53.01.6-1.6-1.7-1.7-1.7-0.91.6-1.6-1.6
Bone: trabecular number3.25.06.72.5-2.4-2.6-2.4-2.4-1.71.9-1.8-2.2
Bone: trabecular spacing2.53.34.8-1.81.82.22.01.81.1-1.91.71.8
Bone: trabecular thickness0.70.81.10.9-0.9-1.0-0.9-0.8-0.80.8-0.8-1.0
Bone: trabecular tissue density0.40.61.50.6-0.6-0.6-0.6-0.6-0.71.2-1.2-0.7
Water consumed over 24 hours0.50.62.00.8-0.8-1.4-0.9-0.6-0.20.4-0.3-0.6
Number of responses in last shaping day1.21.22.31.2-1.2-0.8-1.0-1.3-1.51.0-0.9-0.9