Dpysl5

dihydropyrimidinase-like 5

chr6:31295035–31379348 (-)

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Dpysl5	0.24	0.15	2.0e-09	0.18	0.21	0.21	0.21	6.1e-08	3.0e-09	4.7e-09	4.3e-09
2	OFC	gene expression	Dpysl5	0.36	0.16	1.9e-09	0.31	0.32	0.33	0.34	3.7e-08	2.3e-08	1.6e-08	6.4e-09
3	Brain	gene expression	Dpysl5	0.04	0.03	6.9e-05	0.05	0.04	0.04	0.05	1.5e-05	4.7e-05	4.4e-05	2.9e-05
4	Liver	gene expression	Dpysl5	0.34	0.16	0.0e+00	0.32	0.32	0.32	0.32	8.2e-36	2.0e-36	1.8e-36	1.4e-36
5	Eye	gene expression	Dpysl5	0.86	0.05	1.4e-09	0.25	0.26	0.24	0.28	9.3e-05	7.5e-05	1.4e-04	2.8e-05
6	Liver	mRNA stability	Dpysl5	0.08	0.07	9.7e-08	0.06	0.05	0.05	0.05	1.0e-06	1.5e-06	1.4e-06	1.6e-06
7	NAcc	mRNA stability	Dpysl5	0.05	0.03	9.3e-11	0.06	0.07	0.06	0.06	6.4e-09	1.5e-10	5.3e-10	1.1e-09
8	PL	mRNA stability	Dpysl5	0.05	0.03	1.4e-06	0.06	0.05	0.06	0.06	6.4e-07	3.3e-06	8.3e-07	1.0e-06
9	pVTA	mRNA stability	Dpysl5	0.03	0.02	4.4e-03	0.01	0.02	0.04	0.01	2.5e-02	7.8e-03	6.7e-04	2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	3.3	5.7	7.4	2.3	2.6	2.2	2.7	-2.0	1.9	-2.6	-2.7	-2.3
Area under the delay curve	0.1	0.2	1.4	0.1	0.1	-0.0	0.3	0.1	-0.2	-0.2	-0.1	-1.2
BMI with tail	1.0	3.4	6.6	-2.0	-1.8	-2.4	-1.6	1.9	-2.6	1.4	1.2	0.9
BMI without tail	1.2	3.6	5.8	-2.1	-2.0	-2.3	-1.8	2.1	-2.4	1.7	1.6	0.2
Body weight	2.6	11.4	13.8	-3.4	-3.4	-3.7	-3.4	3.7	-3.3	3.3	3.3	3.0
Weight adjusted by age	0.1	0.1	0.5	0.0	0.2	0.5	0.2	-0.7	-0.3	-0.2	-0.5	0.4
Bone surface	1.2	2.3	3.9	1.2	1.6	1.2	1.9	-0.9	0.6	-1.8	-2.0	-1.8
Bone volume	1.5	2.7	4.1	1.6	1.9	1.3	2.0	-1.0	1.3	-1.9	-2.0	-1.6
Breakpoint value in progressive ratio session	0.8	0.9	1.8	1.0	1.2	0.5	0.7	-0.6	0.7	-1.0	-1.3	-1.2
Number of licking bursts	0.4	0.7	1.7	-0.9	-0.7	-1.3	-0.3	0.9	-1.3	0.3	0.2	-0.6
Context. condit. distance diff. score	0.1	0.1	0.3	0.4	0.3	0.2	0.2	-0.5	0.6	-0.2	-0.0	0.4
Locomotion velocity, session 1	0.3	0.4	0.9	-0.7	-0.5	-0.9	-0.1	0.8	-0.9	0.3	0.4	-0.2
Locomotion distance, session 1	0.8	1.0	2.2	0.8	1.0	0.7	1.5	-0.5	0.7	-1.2	-1.2	-0.8
Locomotion velocity, session 2	0.3	0.4	1.1	-0.4	-0.6	-0.5	-0.5	0.5	-0.1	0.5	0.8	1.1
Locomotion distance, session 2	0.0	0.1	0.2	-0.2	-0.2	0.0	0.0	0.4	-0.3	0.1	0.1	0.5
Locomotion velocity, session 3	0.6	0.7	1.6	0.6	0.8	1.0	0.8	-1.3	0.1	-0.9	-1.1	-0.6
Locomotion distance, session 3	0.3	0.3	0.7	0.2	0.4	0.6	0.8	-0.5	-0.3	-0.7	-0.8	-0.6
Stereotopy head waving bouts, day 3	2.2	2.6	3.2	1.8	1.8	1.6	1.4	-1.7	1.6	-1.7	-1.8	-0.9
Stereotopy head waving duration, day 3	0.3	0.4	0.7	0.8	0.8	0.4	0.3	-0.7	0.9	-0.6	-0.7	0.1
Locomotion velocity, session 7	0.5	0.6	1.3	0.5	0.7	0.5	0.8	-0.2	-0.1	-0.9	-1.1	-1.1
Locomotion distance, session 7	0.3	0.4	1.3	-0.6	-0.2	-0.7	-0.1	0.9	-1.1	0.1	-0.3	-0.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.7	-0.0	-0.1	0.1	-0.0	-0.5	-0.0	-0.0	0.0	0.9
Stereotopy head waving duration, day 7	0.5	0.6	1.8	0.8	0.6	1.1	0.6	-1.4	0.7	-0.7	-0.6	-0.1
Locomotion velocity, session 8	0.3	0.4	0.6	0.7	0.7	0.6	0.6	-0.8	0.7	-0.6	-0.5	-0.5
Locomotion distance, session 8	0.2	0.3	0.6	0.6	0.7	0.5	0.7	-0.5	0.6	-0.6	-0.6	-0.4
Degree of sensitization distance	1.1	1.2	2.2	-1.0	-0.9	-1.5	-1.1	1.4	-0.9	1.0	0.9	0.6
Degree of sensitization stereotypy	0.4	0.4	1.6	-0.6	-0.7	-0.3	-0.6	-0.0	-0.5	0.6	0.7	1.2
Conditioned locomotion	3.9	4.5	7.1	2.0	2.1	2.2	2.0	-2.3	1.8	-2.0	-1.9	-2.7
Cocaine response after cond. corrected	0.3	0.4	0.9	0.5	0.8	0.1	0.7	-0.1	0.4	-0.7	-0.9	-0.8
Cocaine response after cond. not corrected	0.9	1.1	1.7	1.0	1.1	0.7	1.3	-0.8	0.9	-1.2	-1.2	-1.0
Cocaine response before conditioning	2.0	2.4	4.1	1.7	1.3	2.0	1.6	-2.0	1.8	-1.5	-0.8	-0.8
Saline control response	0.9	1.2	2.1	1.2	1.2	1.3	1.0	-1.5	1.2	-1.0	-1.0	-0.3
Bone: connectivity density	2.9	4.6	6.7	2.0	2.3	2.0	2.4	-1.8	1.4	-2.4	-2.6	-2.2
Bone: cortical apparent density	0.3	0.3	1.1	0.4	0.6	0.1	0.7	-0.3	0.2	-0.6	-0.7	-1.0
Bone: cortical area	0.1	0.2	0.5	0.2	0.4	0.0	0.7	0.0	-0.2	-0.6	-0.7	-0.6
Bone: cortical porosity	2.0	2.2	3.4	1.6	1.4	1.8	1.5	-1.8	1.7	-1.4	-1.1	-0.1
Bone: cortical porosity	1.8	2.0	2.7	1.6	1.4	1.6	1.5	-1.5	1.6	-1.4	-1.2	-0.4
Bone: cortical thickness	0.1	0.2	0.5	-0.5	-0.5	-0.4	-0.1	0.5	-0.7	0.3	0.3	-0.2
Bone: cortical thickness	0.9	1.1	2.7	0.8	1.0	0.8	1.2	-0.6	0.4	-1.2	-1.3	-1.6
Bone: cortical tissue density	0.2	0.2	0.7	0.3	0.5	-0.1	0.5	-0.1	0.1	-0.5	-0.6	-0.8
Condit. Reinf. active minus inactive responses	1.3	1.4	2.2	-1.3	-1.1	-1.5	-1.1	1.3	-1.5	1.1	0.9	0.5
Condit. Reinf. active-inactive response ratio	1.2	1.2	1.9	-1.2	-1.1	-1.3	-1.2	1.4	-1.3	1.1	0.9	0.3
Condit. Reinf. active responses	0.1	0.1	0.4	-0.1	-0.0	-0.3	0.2	0.2	-0.4	-0.1	-0.2	-0.6
Condit. Reinf. inactive responses	1.1	1.3	2.2	1.2	1.2	1.0	1.5	-1.1	1.0	-1.3	-1.1	-0.8
Incentive salience index mean	0.1	0.1	0.4	-0.3	-0.1	-0.6	-0.2	0.6	-0.5	0.1	-0.1	0.1
Condit. Reinf. lever presses	0.5	0.7	1.1	1.0	1.0	0.6	0.9	-0.4	1.0	-0.9	-0.9	-0.0
Condit. Reinf. active minus inactive responses	3.4	4.4	8.3	1.7	1.7	2.5	2.2	-2.9	1.0	-2.1	-1.9	-2.3
Condit. Reinf. active-inactive response ratio	1.2	1.3	4.6	0.9	0.8	1.4	1.2	-2.1	0.7	-1.1	-0.8	-0.7
Condit. Reinf. active responses	2.7	3.7	5.7	1.5	1.6	2.3	2.0	-2.3	0.7	-2.0	-2.0	-2.4
Condit. Reinf. inactive responses	1.1	1.4	3.9	0.9	1.2	1.1	1.2	-0.5	0.3	-1.3	-1.5	-2.0
Condit. Reinf. lever presses	2.1	2.9	4.5	1.5	1.4	2.1	1.8	-2.0	1.2	-1.6	-1.4	-2.1
Condit. Reinf. lever reinforcers received	2.5	3.5	5.6	1.5	1.5	2.3	1.9	-2.4	0.7	-1.9	-1.8	-2.3
Conditioned reinforcement - actives	3.2	5.5	8.2	2.6	2.5	2.5	1.9	-2.4	2.9	-2.0	-1.9	-2.2
Conditioned reinforcement - inactives	3.0	4.5	6.7	2.5	2.4	1.6	2.0	-1.8	2.6	-2.2	-2.0	-1.8
Conditioned locomotion	1.1	1.5	2.8	1.4	1.3	1.5	0.8	-1.4	1.7	-1.0	-1.0	-0.5
Patch foraging indifference point 0 sec	0.9	1.7	7.7	-1.0	-0.9	-1.1	-1.0	0.9	-1.0	1.0	0.6	2.8
Patch foraging indifference point AUC	0.6	0.9	3.9	0.3	0.6	-0.1	1.2	-0.2	-0.4	-1.1	-1.1	-2.0
Delay disc. indifference point, 0s delay	2.6	2.9	4.5	-1.6	-1.7	-1.8	-1.8	2.1	-1.1	1.8	2.0	1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.6	-0.1	-0.0	0.3	0.3	-0.3	-0.4	-0.1	-0.1	-0.8
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.5	-0.5	-0.5	-0.4	0.5	-0.5	0.4	0.6	0.1
Delay disc. indifference point, 24s delay	1.1	1.2	2.1	1.3	1.1	1.2	1.2	-1.0	1.4	-1.0	-0.7	-0.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.9	-0.2	-0.1	-0.4	-0.0	0.5	-0.5	0.0	0.1	-0.9
Delay disc. indifference point, 8s delay	0.1	0.1	0.5	0.1	0.1	0.2	0.2	-0.1	0.1	-0.1	-0.1	-0.7
Indifference point function ln k	0.4	0.8	2.4	1.0	0.8	1.2	0.4	-0.9	1.5	-0.4	-0.3	0.6
Indifference point function log k	0.4	0.8	2.4	1.0	0.8	1.2	0.4	-0.9	1.5	-0.4	-0.3	0.6
Patch foraging total patch changes 0 sec	1.0	1.8	8.2	-1.0	-1.0	-1.2	-1.0	1.0	-1.1	0.9	0.7	2.9
Patch foraging total patch changes 12 sec	1.7	2.1	3.2	-1.4	-1.4	-1.7	-1.3	1.6	-1.5	1.2	1.2	1.8
Patch foraging total patch changes 18 sec	0.6	0.9	2.3	-1.0	-0.7	-1.2	-0.5	0.9	-1.5	0.5	0.2	1.0
Patch foraging total patch changes 24 sec	1.0	1.6	2.4	-1.4	-1.4	-1.3	-1.2	1.2	-1.5	1.2	1.2	1.2
Patch foraging total patch changes 6 sec	0.9	1.3	3.6	-1.3	-1.2	-1.4	-0.7	1.0	-1.9	0.7	0.5	1.1
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.4	-0.4	-0.4	-0.5	0.2	-0.6	0.3	0.2	0.3
Patch foraging water rate 0 sec	0.3	0.6	1.3	0.8	0.5	1.1	0.5	-0.8	1.1	-0.4	-0.2	0.9
Patch foraging water rate 12 sec	0.3	0.7	1.7	-0.7	-0.9	-0.1	-1.0	0.5	-0.2	1.2	1.3	0.6
Patch foraging water rate 18 sec	0.3	0.5	1.2	0.3	-0.2	1.0	-0.3	-0.4	1.1	0.4	0.9	0.9
Patch foraging water rate 24 sec	0.9	1.3	2.4	-0.9	-1.1	-0.6	-1.6	0.8	-0.5	1.4	1.5	1.3
Patch foraging water rate 6 sec	0.4	0.6	1.8	-0.4	-0.7	0.1	-0.8	0.4	0.4	1.0	1.4	1.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.2	-0.3	0.0	-0.1	-0.0	-0.3	0.1	0.2	0.3
Distance traveled before self-admin	0.1	0.2	0.7	0.1	-0.0	0.6	0.3	-0.2	0.5	0.0	0.4	-0.8
Distance traveled after self-admin	1.6	2.0	3.0	-1.5	-1.5	-1.4	-1.3	1.7	-1.1	1.6	1.7	0.6
Extensor digitorum longus weight	3.8	14.9	17.2	3.7	3.9	4.1	4.1	-4.1	2.8	-4.1	-4.1	-3.8
Bone: elastic displacement	1.2	1.4	2.0	1.3	1.4	1.0	1.0	-0.9	1.4	-1.0	-1.3	-1.1
Bone: elastic work	0.9	1.2	2.4	1.0	1.2	0.8	1.2	-0.7	0.8	-1.0	-1.4	-1.6
Bone: endosteal estimation	0.3	0.7	1.5	0.8	1.0	0.4	1.0	-0.1	0.5	-1.1	-1.2	-1.0
Bone: endosteal perimeter	0.1	0.2	0.5	0.3	0.5	0.1	0.6	0.1	0.1	-0.6	-0.7	-0.7
Epididymis fat weight	16.4	56.2	63.9	-7.8	-7.7	-7.7	-8.0	7.6	-7.3	7.7	7.2	6.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.9	-0.2	-0.1	-0.6	-0.2	0.2	-0.6	0.0	-0.3	0.9
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.2	0.3	0.1	0.2	-0.2	0.1	-0.3	-0.4	-0.6
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.1	0.2	-0.3	0.0	0.2	-0.2	-0.1	-0.5	0.4
Delay discount exponential model param	0.3	0.3	1.8	-0.4	-0.4	-0.3	-0.6	0.3	-0.1	0.5	0.4	1.3
Extinction: sum of active levers before priming	0.3	0.3	0.6	0.8	0.7	-0.1	0.3	-0.2	0.6	-0.6	-0.5	0.6
Active lever presses in extinction session 6	1.1	1.1	1.8	1.3	1.2	1.0	0.8	-1.0	1.3	-1.0	-1.0	-0.6
Bone: final force	0.0	0.1	0.1	0.0	0.1	-0.3	0.3	0.3	-0.2	-0.3	-0.3	-0.3
Bone: final moment	0.1	0.1	0.3	0.1	0.2	-0.3	0.4	0.3	-0.2	-0.3	-0.4	-0.5
Food consumed during 24 hour testing period	0.1	0.1	0.7	-0.1	0.1	0.1	0.4	-0.2	-0.3	-0.3	-0.3	-0.8
Glucose	0.4	0.7	1.4	-1.0	-0.8	-0.9	-0.7	0.8	-1.2	0.7	0.5	0.8
Heart weight	2.7	4.2	6.0	-1.8	-2.1	-2.1	-2.1	2.3	-1.1	2.1	2.5	2.1
Delay discount hyperbolic model param	0.2	0.2	1.2	-0.2	-0.2	0.0	-0.4	0.0	0.1	0.3	0.3	1.1
Intermittent access intake day 1-15 change	0.3	0.6	1.6	0.8	0.7	1.1	0.7	-0.8	1.3	-0.6	-0.4	-0.4
Intermittent access intake escalation	0.1	0.2	0.8	0.4	0.3	0.7	0.4	-0.4	0.9	-0.2	-0.1	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.3	0.0	0.1	0.4	0.3	-0.2	0.2	-0.1	0.0	-0.6
Intermitt. access day 1 inactive lever presses	0.4	1.5	2.2	1.3	1.2	1.2	1.2	-1.5	1.2	-1.3	-1.2	-0.8
Intermitt. access day 15 inactive lever presses	2.2	4.5	6.8	1.9	2.1	1.6	2.6	-2.0	1.3	-2.5	-2.5	-2.3
Intermitt. access escalation Index	1.8	2.6	5.8	-1.9	-1.6	-2.0	-1.2	1.6	-2.4	1.1	0.8	1.2
Intermittent access day 1 total infusions	3.3	5.3	6.1	2.4	2.4	2.4	2.3	-2.5	2.1	-2.3	-2.3	-2.1
Intermittent access day 15 total infusions	2.1	3.1	4.5	1.9	1.8	2.0	1.7	-1.8	2.1	-1.7	-1.5	-1.3
Intermittent access terminal intake (last 3 days)	3.3	4.3	5.5	2.2	2.1	2.3	2.1	-2.2	2.3	-2.0	-1.8	-1.8
Intermittent access total infusions	3.7	4.4	6.4	2.4	2.2	2.3	1.8	-2.3	2.5	-1.9	-1.8	-1.4
Intermittent access day 1 locomotion	1.9	2.4	3.4	1.9	1.7	1.5	1.5	-1.6	1.7	-1.6	-1.5	-0.3
Intermittent access day 15 total locomotion	0.2	0.4	0.7	0.6	0.7	0.5	0.5	-0.7	0.6	-0.6	-0.7	-0.8
Intermittent access total locomotion	0.8	1.0	2.3	1.3	1.1	0.8	0.6	-1.0	1.5	-0.8	-0.9	-0.2
Intermittent access standard deviation	0.9	2.0	2.7	1.6	1.6	1.3	1.5	-1.4	1.6	-1.4	-1.4	-0.3
Left kidney weight	0.1	0.4	2.3	0.4	0.1	0.0	-0.1	0.1	0.9	0.0	0.2	1.5
Right kidney weight	0.4	1.9	4.9	-0.9	-1.2	-1.3	-1.4	1.5	-0.1	1.4	1.6	2.2
Cocaine induced anxiety	0.1	0.1	0.3	0.3	0.4	-0.1	0.3	-0.1	0.2	-0.5	-0.5	-0.0
Post-drug Anxiety	1.7	1.8	2.5	-1.4	-1.4	-1.6	-1.2	1.6	-1.3	1.3	1.3	1.1
Baseline Anxiety	3.2	3.7	4.6	-2.1	-2.1	-1.8	-1.9	2.0	-2.0	2.1	1.9	1.0
Tail length	0.2	0.7	1.6	-0.6	-0.9	-0.6	-0.9	1.0	-0.0	1.0	1.3	0.8
Length with tail	1.1	4.9	9.1	-1.7	-2.0	-1.8	-2.4	2.3	-0.7	2.5	2.7	3.0
Length without tail	0.6	2.0	8.7	-0.7	-0.9	-1.1	-1.3	1.3	-0.2	1.3	1.2	2.9
LgA early post infusion interval	1.0	1.3	1.8	-1.2	-1.2	-1.1	-1.3	1.0	-1.3	1.2	1.2	0.6
LgA late post infusion interval	1.2	1.4	2.1	1.4	1.4	1.0	0.9	-1.1	1.2	-1.1	-1.4	-1.0
LgA early loading	2.2	4.2	5.7	2.2	2.3	1.7	2.2	-1.8	2.0	-2.3	-2.4	-1.2
LgA late loading	0.5	1.1	1.5	1.1	1.1	0.9	1.1	-0.8	1.2	-1.1	-1.0	-1.0
LgA early average infusions	1.9	2.4	3.4	1.5	1.7	1.3	1.8	-1.4	1.4	-1.7	-1.8	-0.9
LgA late average infusions	1.1	1.6	2.8	-1.3	-1.5	-1.0	-1.3	1.3	-0.8	1.4	1.7	0.9
LgA early timeout	3.4	3.6	4.2	2.0	2.0	2.0	2.1	-2.0	2.0	-2.0	-2.0	-0.9
LgA late timeout	0.8	1.0	1.8	-1.3	-1.1	-1.2	-0.8	1.0	-1.3	0.9	0.8	0.3
LgA early titration	0.9	1.2	2.2	1.0	1.2	1.0	1.3	-1.1	0.9	-1.2	-1.5	-0.4
LgA late titration	1.6	2.4	3.5	-1.8	-1.9	-1.2	-1.4	1.5	-1.5	1.6	1.8	0.8
LgA total infusion	0.2	0.3	0.5	-0.5	-0.6	-0.4	-0.6	0.7	-0.1	0.6	0.7	0.7
Times rat made contact with spout	1.3	1.5	2.1	1.1	1.2	1.2	1.3	-1.3	0.7	-1.3	-1.5	-1.3
Lifetime Intake	3.9	4.8	7.3	2.5	2.4	2.3	1.8	-2.3	2.7	-2.0	-2.0	-1.3
Liver weight, left	3.3	5.4	6.7	-2.2	-2.4	-2.4	-2.6	2.6	-1.8	2.5	2.6	1.8
Liver weight, right	7.9	13.9	18.7	-3.3	-3.8	-3.6	-4.1	3.9	-2.3	4.0	4.3	3.9
Locomotor activity	0.8	1.2	2.9	-0.8	-0.8	-1.7	-1.0	1.3	-1.0	0.8	0.7	1.4
Locomotor testing distance	0.1	0.2	0.7	-0.1	0.1	-0.8	-0.1	0.2	-0.7	-0.2	-0.6	0.2
Locomotor testing rearing	0.5	0.9	2.4	1.1	1.2	0.5	0.7	-1.0	0.6	-1.1	-1.5	0.2
Locomotion in novel chamber	0.1	0.1	0.3	-0.2	-0.2	0.0	-0.4	-0.0	-0.3	0.2	0.2	-0.6
Locomotion in novel chamber post-restriction	2.9	4.7	6.1	-2.1	-2.1	-2.2	-2.5	2.0	-2.1	2.2	1.9	2.4
Fecal boli incidents, locomotor time 1	0.7	1.0	2.9	1.2	1.0	1.3	0.8	-1.0	1.7	-0.8	-0.5	-0.2
Change in fecal boli incidents, locomotor task	4.2	4.2	5.4	-2.1	-2.0	-2.3	-2.1	2.3	-2.0	2.1	1.9	1.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.5	0.2	-0.0	0.2	-0.1	0.0	0.7	0.2	0.4	-0.5
Bouts of movement, locomotor time 1	0.9	1.0	1.6	0.5	0.7	1.0	1.2	-1.3	-0.2	-1.1	-1.1	-1.2
Total resting periods, locomotor time 1	1.1	1.3	2.3	0.6	0.8	1.1	1.4	-1.3	-0.2	-1.2	-1.3	-1.5
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.4	-0.3	0.0	-0.1	0.1	-0.5	0.2	0.1	-0.2
Distance moved, locomotor task time 1	0.6	0.9	1.5	-0.7	-0.8	-1.1	-1.1	1.2	-0.2	1.0	1.1	0.9
Vertical activity count, locomotor time 1	0.2	0.4	0.8	-0.5	-0.6	-0.7	-0.7	0.9	-0.3	0.7	0.8	0.3
Time >=10cm from walls, locomotor time 2	0.6	0.8	1.8	1.1	0.9	0.9	0.8	-0.7	1.3	-0.8	-0.4	-1.1
Bouts of movement, locomotor time 2	0.1	0.2	0.5	-0.7	-0.6	-0.3	-0.2	0.1	-0.7	0.4	0.5	0.5
Total resting periods, locomotor time 2	0.1	0.1	0.6	-0.5	-0.4	0.0	0.1	-0.2	-0.7	0.1	0.1	0.3
Rest time, locomotor task time 2	0.6	0.8	1.4	0.5	0.8	0.9	1.2	-1.0	0.1	-1.0	-1.2	-0.7
Distance moved, locomotor task time 2	0.5	0.6	1.2	-0.5	-0.7	-0.9	-1.0	1.1	-0.1	0.9	1.1	0.1
Vertical activity count, locomotor time 2	0.2	0.2	0.6	-0.1	-0.4	-0.4	-0.7	0.6	0.3	0.5	0.8	0.1
Light reinforcement 1	1.3	3.2	5.5	1.6	1.9	1.5	2.3	-1.9	0.9	-2.2	-2.4	0.0
Light reinforcement 2	1.8	2.8	4.5	1.4	1.7	1.7	2.1	-1.7	1.1	-1.9	-1.8	-1.5
Bone: marrow area	0.3	0.7	1.5	0.8	1.0	0.4	1.0	-0.1	0.5	-1.1	-1.2	-1.0
Bone: maximum diameter	0.4	0.7	1.8	0.6	0.9	0.3	1.1	-0.1	0.0	-1.1	-1.3	-0.9
Bone: maximum force	0.1	0.1	0.3	0.2	0.3	-0.0	0.5	-0.0	0.1	-0.4	-0.4	-0.2
Bone: maximum moment	0.1	0.2	0.4	0.3	0.4	0.1	0.6	-0.0	0.1	-0.5	-0.6	-0.5
Mean time between licks in bursts	1.3	3.2	4.1	-1.8	-1.9	-1.7	-2.0	2.0	-1.3	2.0	2.0	1.3
Mean num. licks in bursts	0.7	1.1	2.5	1.1	1.0	1.6	0.7	-1.2	1.4	-0.7	-0.7	-0.1
Cd content in liver	0.1	0.1	0.9	-0.0	0.1	-0.3	-0.1	0.2	-0.0	-0.0	-0.2	1.0
Co content in liver	5.4	6.3	7.6	2.6	2.6	2.5	2.8	-2.3	2.7	-2.7	-2.5	-1.9
Cu content in liver	0.2	0.2	0.5	0.6	0.4	0.3	0.5	-0.3	0.7	-0.4	-0.2	-0.3
Fe content in liver	1.2	1.5	2.6	1.6	1.4	0.7	1.3	-0.9	1.6	-1.3	-1.2	-0.3
K content in liver	0.1	0.1	0.4	-0.1	0.0	-0.6	0.5	0.5	-0.1	-0.3	-0.3	-0.0
Mg content in liver	0.4	0.4	2.0	0.1	0.2	-0.8	0.5	0.6	0.3	-0.4	-0.4	1.4
Mn content in liver	0.4	0.4	1.8	-0.4	-0.1	-0.8	-0.2	0.6	-0.7	-0.0	-0.5	1.3
Na content in liver	1.0	1.1	2.5	1.2	1.0	1.0	1.2	-0.8	1.6	-1.0	-0.6	-0.9
Rb content in liver	0.2	0.3	1.2	-0.2	-0.1	-0.9	-0.2	0.6	-0.3	0.1	-0.0	1.1
Se content in liver	0.4	0.4	2.5	-0.3	-0.3	-0.8	-0.4	0.4	-0.2	0.2	0.2	1.6
Sr content in liver	0.1	0.1	0.3	-0.1	-0.2	0.2	-0.1	0.1	0.3	0.3	0.4	-0.5
Zn content in liver	1.2	1.3	3.3	-0.9	-1.0	-1.3	-0.8	1.5	-0.5	1.0	1.0	1.8
Bone: minimum diameter	0.3	0.5	1.3	-0.7	-0.6	-1.0	-0.5	1.1	-0.8	0.4	0.2	0.6
Time in familiar zone, hab. session 1	1.0	1.0	1.7	-0.9	-0.8	-1.3	-1.0	1.3	-0.9	0.8	0.8	1.1
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.5	-0.5	-0.1	-0.7	-0.1	-0.4	0.6	0.4	0.8
Total zone transitions, hab. session 1	0.1	0.2	0.2	0.4	0.5	0.5	0.4	-0.5	0.3	-0.4	-0.4	0.1
Total locomotion distance, hab. session 1	0.2	0.3	0.9	0.8	0.7	0.3	0.5	-0.2	0.9	-0.5	-0.5	-0.4
Locomotion velocity, hab. session 1	0.9	1.3	1.7	1.3	1.3	0.8	1.2	-0.8	1.3	-1.2	-1.1	-1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.4	-0.3	-0.2	-0.4	-0.1	-0.0	-0.7	0.1	-0.1	0.3
Time in novel zone, hab. session 2	0.3	0.3	0.5	-0.3	-0.5	-0.4	-0.7	0.7	0.0	0.6	0.7	0.4
Total zone transitions, hab. session 2	0.0	0.1	0.3	-0.2	-0.0	-0.1	0.2	0.2	-0.5	-0.1	-0.2	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.3	-0.0	-0.0	0.4	-0.0	-0.6	-0.2	-0.3	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.1	0.1	0.2	0.6	-0.2	-0.4	-0.4	-0.5	-0.5
Novel to familiar place preference ratio	1.0	1.1	2.3	-0.9	-1.0	-0.8	-1.1	0.9	-0.6	1.1	1.1	1.5
Novelty place preference	1.5	1.6	2.9	-1.2	-1.3	-1.0	-1.4	1.1	-0.8	1.4	1.3	1.7
Time in novel zone, NPP test	1.6	1.8	3.6	-1.2	-1.3	-1.0	-1.5	1.1	-0.8	1.4	1.4	1.9
Total zone transitions, NPP test	1.1	1.6	2.5	1.3	1.3	1.3	1.6	-1.2	1.1	-1.4	-1.3	-0.7
Total locomotion distance, NPP test	1.5	2.1	2.9	1.5	1.5	1.4	1.7	-1.6	1.2	-1.6	-1.5	-0.8
Locomotion velocity, NPP test	2.4	3.3	4.6	1.8	2.0	1.7	2.2	-1.9	1.5	-2.0	-2.0	-1.3
Intraocular pressure	6.1	8.8	11.1	-2.9	-2.8	-3.3	-3.3	3.1	-2.5	3.0	2.8	2.8
Delta distance traveled before/after self-admin	2.2	2.4	3.8	-1.7	-1.6	-1.7	-1.5	1.6	-1.9	1.4	1.3	0.6
Delta ambulatory time before/after self-admin	0.6	0.7	1.4	-0.8	-0.8	-1.1	-0.6	1.0	-1.2	0.6	0.5	0.6
Parametrial fat weight	14.1	33.1	44.3	-6.7	-6.4	-5.7	-5.4	5.8	-6.5	5.8	5.6	3.2
Pavlov. Cond. lever latency	0.8	1.1	1.7	-1.0	-1.2	-0.7	-1.3	0.8	-0.7	1.3	1.3	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.0	0.1	-0.3	0.1	-0.0	-0.2	-0.2	-0.2	0.6
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	0.2	-0.1	0.1	0.1	0.3	-0.2	-0.1	0.4
Pavlov. Cond. index score	0.2	0.3	0.6	0.5	0.6	-0.0	0.6	-0.2	0.2	-0.7	-0.7	0.3
Pavlov. Cond. latency score	0.2	0.2	0.6	0.4	0.6	-0.0	0.6	-0.2	0.1	-0.7	-0.8	0.3
Pavlov. Cond. lever contacts	0.6	0.7	1.1	0.9	1.0	0.5	1.0	-0.5	0.7	-1.0	-1.0	-0.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.3	-0.4	-0.0	-0.5	0.3	-0.0	0.6	0.6	-0.1
Pavlov. Cond. intertrial magazine entries	1.6	1.9	2.6	1.5	1.4	1.3	1.4	-1.2	1.6	-1.3	-1.2	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.2	0.9	1.0	0.4	1.0	-0.6	0.6	-1.1	-1.1	-0.2
Pavlov. Cond. response bias	0.7	0.9	1.4	1.0	1.1	0.7	1.1	-0.8	0.9	-1.2	-1.1	-0.4
Pavlov. Cond. lever latency	1.6	2.1	5.5	-1.1	-1.1	-1.7	-1.5	1.5	-0.8	1.4	1.1	2.3
Pavlov. Cond. magazine entry latency	0.5	0.6	4.1	0.1	0.2	0.7	0.6	-0.4	-0.3	-0.5	-0.4	-2.0
Pavlov. Cond. change in total contacts	0.7	1.2	4.8	0.5	0.7	1.1	0.9	-1.2	-0.0	-0.9	-0.9	-2.2
Pavlov. Cond. index score	1.3	1.8	6.2	0.8	0.9	1.5	1.3	-1.3	0.4	-1.2	-1.0	-2.5
Pavlov. Cond. latency score	1.4	1.9	6.3	0.9	0.9	1.6	1.4	-1.3	0.5	-1.2	-1.1	-2.5
Pavlov. Cond. lever contacts	1.0	1.4	3.4	0.9	0.8	1.4	1.2	-1.3	0.6	-1.1	-0.9	-1.8
Pavlov. Cond. magazine entry number	0.4	0.5	3.7	0.1	-0.0	-0.4	-0.5	0.2	0.5	0.3	0.3	1.9
Pavlov. Cond. intertrial magazine entries	3.3	5.0	7.5	-2.1	-2.2	-2.2	-2.4	2.1	-1.7	2.3	2.2	2.7
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	5.5	0.5	0.6	1.1	1.1	-1.0	0.1	-0.9	-0.8	-2.4
Pavlov. Cond. response bias	1.7	2.3	7.2	1.1	1.1	1.6	1.6	-1.5	0.7	-1.4	-1.1	-2.7
LgA PC1 addiction-like behavior	0.0	0.1	0.3	0.2	0.2	0.4	0.4	-0.2	0.5	-0.2	-0.1	0.3
Time in closed arm before self-admin	0.5	0.6	1.2	-0.7	-0.6	-0.8	-1.1	0.8	-0.5	0.9	0.6	0.9
Time in closed arm after self-admin	0.9	1.0	2.1	-1.0	-0.7	-1.1	-1.4	0.9	-1.2	1.1	0.6	0.6
Time in open arm before self-admin	0.0	0.0	0.2	-0.0	-0.0	0.2	0.3	-0.2	-0.3	-0.1	-0.1	0.4
Time in open arm after self-admin	0.7	0.8	1.3	0.8	0.8	0.7	1.1	-0.8	0.6	-1.1	-0.9	-0.8
Bone: periosteal estimation	0.4	0.9	1.8	0.9	1.1	0.5	1.2	-0.2	0.5	-1.2	-1.3	-1.0
Bone: periosteal perimeter	0.1	0.2	0.6	0.3	0.4	0.2	0.8	-0.0	0.1	-0.7	-0.7	-0.6
Bone: post-yield work	1.3	1.9	2.8	1.6	1.5	1.5	1.3	-1.4	1.7	-1.4	-1.3	0.0
Progressive ratio test 1 active lever presses	2.2	2.7	4.4	2.0	1.8	1.6	1.3	-1.7	2.1	-1.5	-1.5	-1.0
Progressive ratio test 1 breakpoint	2.2	2.7	4.6	2.0	1.8	1.6	1.3	-1.7	2.1	-1.5	-1.5	-0.9
Progressive ratio test 1 inactive lever presses	3.9	5.7	7.7	2.7	2.5	2.2	2.2	-2.4	2.8	-2.3	-2.2	-2.1
Progressive ratio test 2 active lever presses	1.4	1.6	4.2	1.6	1.3	1.5	0.8	-1.3	2.0	-0.9	-0.7	-0.7
Progressive ratio test 2 breakpoint	1.2	1.4	3.8	1.5	1.2	1.4	0.7	-1.2	2.0	-0.8	-0.6	-0.6
Progressive ratio test 2 inactive lever presses	2.0	3.3	4.9	2.1	1.9	1.8	1.6	-1.8	2.2	-1.7	-1.5	-1.5
ShA PR total presses	1.8	2.1	2.4	1.4	1.5	1.4	1.6	-1.4	1.5	-1.5	-1.6	-1.0
Incentive Sensitization - Responses	0.5	0.7	2.3	1.1	0.8	1.0	0.7	-0.7	1.5	-0.7	-0.4	0.1
Incentive Sensitization - Breakpoint	0.4	0.5	1.6	0.9	0.6	0.9	0.6	-0.5	1.3	-0.5	-0.2	0.2
LgA PR total presses	0.5	0.5	0.9	0.6	0.6	0.9	0.8	-1.0	0.6	-0.7	-0.8	0.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.1	-0.0	-0.6	0.3	0.4	-0.7	-0.3	-0.3	-0.5
Progressive ratio	0.0	0.0	0.1	-0.1	-0.1	-0.3	-0.4	0.2	-0.2	0.1	0.0	0.2
Food seeking constrained by brief footshock	6.3	7.7	14.2	3.5	3.0	2.9	2.4	-2.7	3.8	-2.6	-2.3	0.1
Seeking ratio, punishment vs. effort	0.7	1.0	2.0	1.2	1.1	1.1	1.1	-1.0	1.4	-0.9	-0.7	-0.2
Retroperitoneal fat weight	26.2	111.9	139.2	-11.6	-11.1	-11.1	-10.8	10.7	-11.8	10.6	9.5	7.4
Reaction time number correct	0.3	0.6	1.1	0.6	0.7	1.0	1.0	-0.9	0.4	-0.8	-0.8	-0.7
Reaction time mean minus median	0.1	0.3	1.9	0.1	0.2	0.4	-0.0	-0.4	-0.0	-0.0	-0.2	-1.4
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.3	-0.1	-0.1	-0.3	0.1	-0.3	0.3	0.1	-0.5
Reaction time num false alarms	0.7	1.0	2.7	-1.1	-0.8	-1.1	-0.6	0.9	-1.6	0.5	0.2	1.4
Reaction time num false alarms AUC	0.7	1.1	2.8	-1.1	-0.9	-1.2	-0.5	1.0	-1.7	0.5	0.2	1.5
Reaction time trials correct on left	0.3	0.6	1.1	0.6	0.7	1.0	1.0	-0.9	0.4	-0.8	-0.8	-0.7
Reaction time trials on left	0.4	0.7	1.0	0.7	0.7	1.0	1.0	-0.9	0.4	-0.9	-0.8	-0.8
Reaction time mean	0.6	0.9	1.9	-0.8	-0.9	-0.9	-1.2	1.1	-0.2	1.2	1.4	-0.1
Reaction time mean AUC	0.5	0.7	1.6	-0.7	-0.8	-0.8	-1.1	1.0	-0.1	1.1	1.3	-0.0
Median of all reaction times	0.8	1.2	2.4	-0.8	-1.0	-1.1	-1.2	1.4	-0.1	1.3	1.5	0.4
Reaction time omissions	0.0	0.1	0.2	-0.1	0.1	-0.4	-0.1	0.2	-0.4	-0.1	-0.2	-0.3
Reaction time false alarm rate	1.2	1.7	3.2	-1.4	-1.1	-1.6	-1.0	1.4	-1.8	0.9	0.5	1.6
Reaction time premature initiation rate	0.2	0.2	0.8	-0.4	-0.5	-0.2	-0.4	0.1	-0.4	0.4	0.5	0.9
Reaction time premature initiations	0.0	0.1	0.2	-0.0	-0.1	0.3	0.1	-0.3	-0.1	-0.0	0.0	0.4
Std. dev. reaction times	0.2	0.4	1.4	-0.5	-0.4	-0.2	-0.7	0.4	-0.4	0.6	0.6	-1.2
Reaction time trials completed	0.4	0.7	1.0	0.7	0.7	1.0	1.0	-0.9	0.4	-0.9	-0.8	-0.8
Reaction time trials AUC	0.4	0.8	1.4	0.7	0.8	1.2	1.1	-1.1	0.5	-1.0	-0.9	-0.8
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.3	0.2	0.7	0.1	-0.3	0.8	0.0	0.2	-0.4
Run reversals in cocaine runway, males	0.4	0.4	0.8	0.7	0.6	0.9	0.4	-0.7	0.9	-0.4	-0.3	-0.4
Latency to leave start box in cocaine runway	0.9	1.0	2.3	0.9	0.9	1.0	1.1	-0.8	0.9	-0.9	-0.9	-1.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.6	0.4	0.4	0.3	0.6	-0.2	0.3	-0.5	-0.5	-0.8
Latency to leave start box in cocaine runway, M	0.7	0.6	1.4	0.6	0.6	1.2	0.6	-0.9	0.9	-0.5	-0.4	-1.2
Std. dev. time between licks in bursts	0.6	0.8	1.6	-0.9	-0.9	-1.2	-0.7	1.1	-1.1	0.6	0.6	0.3
Total sessions with >9 infusions	1.8	2.2	4.1	1.8	1.7	1.5	1.0	-1.6	2.0	-1.3	-1.3	-0.3
Short access day 1 total inactive lever presses	6.0	7.8	9.7	3.1	3.1	2.1	2.8	-2.5	2.8	-3.0	-2.9	-2.7
Short access day 10 total inactive lever presses	1.1	2.7	3.7	1.6	1.7	1.5	1.9	-1.8	1.1	-1.9	-1.9	-1.2
Short access day 1 total infusions	4.6	6.0	7.7	2.8	2.7	2.2	2.2	-2.5	2.5	-2.5	-2.6	-2.1
Short access day 10 total infusions	3.1	3.9	6.3	2.4	2.2	2.0	1.7	-1.9	2.5	-1.8	-1.7	-1.3
Short access total infusions	2.0	2.6	4.2	2.0	1.9	1.5	1.2	-1.6	2.1	-1.5	-1.5	-0.9
ShA early post infusion interval	0.6	0.6	1.2	-1.0	-0.9	-0.7	-0.6	0.7	-1.1	0.7	0.6	0.4
ShA late post infusion interval	2.6	2.6	3.6	-1.7	-1.7	-1.5	-1.7	1.5	-1.9	1.6	1.7	1.0
ShA early loading	0.3	0.3	0.8	0.5	0.5	-0.5	0.2	0.2	0.7	-0.3	-0.5	0.9
ShA late loading	0.4	0.5	1.0	0.7	0.9	0.3	0.8	-0.5	0.7	-0.9	-1.0	0.4
Short access day 1 locomotion	3.7	4.6	6.4	2.2	2.2	2.3	1.9	-2.5	1.9	-2.1	-2.1	-1.9
Short access day 10 total locomotion	1.2	2.2	3.7	1.6	1.5	1.8	1.5	-1.9	1.5	-1.5	-1.3	0.3
Short access total locomotion	0.6	0.8	1.7	1.1	0.9	0.9	0.5	-1.0	1.3	-0.6	-0.6	0.3
ShA early average infusions	1.7	2.0	3.7	1.8	1.8	0.8	1.1	-1.0	1.9	-1.4	-1.6	0.5
ShA late average infusions	2.1	2.2	3.7	1.6	1.8	1.1	1.5	-1.2	1.4	-1.6	-1.9	-0.8
ShA early timeout	0.7	0.7	1.9	1.1	1.0	0.2	0.6	-0.3	1.4	-0.7	-0.8	0.7
ShA late timeout	2.1	2.3	3.5	1.6	1.8	1.3	1.6	-1.4	1.6	-1.5	-1.9	-0.7
ShA early titration	0.5	0.5	2.0	0.9	0.9	0.2	0.3	-0.3	1.4	-0.5	-0.6	0.6
ShA late titration	1.6	1.7	2.9	1.3	1.5	1.1	1.5	-1.1	1.2	-1.5	-1.7	-0.6
ShA total infusions	0.9	1.1	2.0	1.1	1.3	0.8	1.1	-0.8	1.1	-1.1	-1.4	-0.3
One hour access (0.3 mA shock)	2.5	2.9	4.4	1.8	1.7	1.9	1.5	-1.8	2.1	-1.4	-1.3	-1.6
Shock compulsivity	0.9	1.6	4.2	1.4	1.2	1.5	1.0	-1.3	2.0	-1.2	-0.8	-0.6
Compulsive drug intake	1.9	2.3	3.0	-1.6	-1.4	-1.7	-1.3	1.7	-1.6	1.3	1.2	1.6
One hour access (shock baseline)	3.4	5.2	7.5	2.4	2.2	2.6	2.0	-2.4	2.7	-1.9	-1.7	-2.4
Social response proportion	0.1	0.1	0.2	-0.0	-0.1	-0.2	-0.3	0.4	0.4	0.4	0.4	0.3
Social responses	0.2	0.2	1.0	-0.4	-0.5	-0.5	-0.2	0.4	-0.2	0.3	0.4	1.0
Social time	0.2	0.3	1.3	-0.1	-0.3	-0.2	-0.4	0.3	0.3	0.4	0.6	1.1
Soleus weight	4.0	11.7	14.0	3.4	3.5	3.7	3.7	-3.3	2.9	-3.6	-3.5	-3.1
Bone: stiffness	0.0	0.0	0.1	-0.2	-0.3	-0.2	0.2	-0.2	-0.4	-0.1	0.2	0.3
Tibialis anterior weight	2.7	9.1	11.3	2.6	2.9	3.3	3.4	-3.1	1.7	-3.3	-3.3	-3.2
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.0	-0.5	-0.5	-0.2	-1.0	0.3	-0.0	0.8	0.6	0.2
Time to tail flick, vehicle, after self-admin	2.7	3.6	5.0	-2.2	-1.9	-1.8	-2.2	1.8	-2.0	2.2	1.6	0.8
Time to tail flick, test, before self-admin	0.1	0.1	0.5	0.4	0.3	0.2	0.0	-0.3	0.5	-0.3	-0.3	-0.7
Time to tail flick, test, after self-admin	0.7	0.7	2.0	0.8	0.8	1.1	0.4	-0.8	1.4	-0.4	-0.5	-0.6
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.5	-0.8	-0.5	-0.6	-0.4	0.6	-1.2	0.4	0.1	0.1
Delta time to tail flick, test, before/after SA	1.9	2.0	3.0	1.5	1.5	1.6	1.5	-1.3	1.7	-1.3	-1.2	-0.8
Tibia length	2.4	6.6	10.6	-2.1	-2.4	-2.6	-2.7	2.8	-1.4	2.6	2.8	3.3
Ambulatory time before self-admin	0.1	0.2	0.4	0.3	0.1	0.6	0.4	-0.3	0.6	-0.1	0.3	-0.6
Ambulatory time after self-admin	1.1	1.3	2.4	-1.0	-1.2	-1.1	-0.9	1.3	-0.7	1.2	1.6	0.8
Bone: tissue strength	0.6	0.6	1.0	-0.9	-1.0	-0.5	-0.8	0.7	-0.8	1.0	1.0	-0.2
Total heroin consumption	2.4	2.8	3.5	1.7	1.9	1.4	1.7	-1.6	1.4	-1.8	-1.8	-1.5
Total infusions	0.1	0.1	0.3	-0.2	-0.3	-0.2	-0.3	0.4	0.1	0.3	0.3	0.6
Bone: trabecular number	2.7	4.4	5.6	2.1	2.3	1.9	2.4	-1.5	1.9	-2.3	-2.3	-2.2
Bone: trabecular spacing	2.5	3.3	6.9	-1.4	-1.9	-1.5	-1.9	1.3	-0.9	1.9	2.2	2.6
Bone: trabecular thickness	0.5	0.6	1.3	0.7	1.0	0.3	0.9	-0.0	0.7	-0.9	-1.1	-0.6
Bone: trabecular tissue density	0.3	0.5	1.0	0.7	0.6	0.5	0.8	-0.8	0.6	-0.7	-0.5	-1.0
Water consumed over 24 hours	0.3	0.3	1.8	-0.1	0.1	-0.1	0.6	-0.1	-0.7	-0.4	-0.5	-1.3
Number of responses in last shaping day	0.7	0.8	1.3	1.1	1.0	0.6	0.5	-0.6	1.0	-0.7	-0.7	-1.1