Hub : Genes

Dpysl5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Dpysl5 0.04 0.03 6.9e-05 0.05 0.04 0.04 0.05 1.5e-05 4.7e-05 4.4e-05 2.9e-05
2 IC gene expression Dpysl5 0.24 0.15 2.0e-09 0.18 0.21 0.21 0.21 6.1e-08 3.0e-09 4.7e-09 4.3e-09
3 Liver gene expression Dpysl5 0.34 0.16 0.0e+00 0.32 0.32 0.32 0.32 8.2e-36 2.0e-36 1.8e-36 1.4e-36
4 Eye gene expression Dpysl5 0.86 0.05 1.4e-09 0.25 0.26 0.24 0.28 9.3e-05 7.5e-05 1.4e-04 2.8e-05
5 OFC gene expression Dpysl5 0.36 0.16 1.9e-09 0.31 0.32 0.33 0.34 3.7e-08 2.3e-08 1.6e-08 6.4e-09
6 NAcc mRNA stability Dpysl5 0.05 0.03 9.3e-11 0.06 0.07 0.06 0.06 6.4e-09 1.5e-10 5.3e-10 1.1e-09
7 Liver mRNA stability Dpysl5 0.08 0.07 9.7e-08 0.06 0.05 0.05 0.05 1.0e-06 1.5e-06 1.4e-06 1.6e-06
8 PL mRNA stability Dpysl5 0.05 0.03 1.4e-06 0.06 0.05 0.06 0.06 6.4e-07 3.3e-06 8.3e-07 1.0e-06
9 pVTA mRNA stability Dpysl5 0.03 0.02 4.4e-03 0.01 0.02 0.04 0.01 2.5e-02 7.8e-03 6.7e-04 2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density3.35.77.42.22.32.7-2.02.6-2.61.9-2.7-2.3
Area under the delay curve0.10.21.4-0.00.10.30.10.1-0.2-0.2-0.1-1.2
BMI with tail1.03.46.6-2.4-2.0-1.61.9-1.81.4-2.61.20.9
BMI without tail1.23.65.8-2.3-2.1-1.82.1-2.01.7-2.41.60.2
Body weight2.611.413.8-3.7-3.4-3.43.7-3.43.3-3.33.33.0
Weight adjusted by age0.10.10.50.50.00.2-0.70.2-0.2-0.3-0.50.4
Bone surface1.22.33.91.21.21.9-0.91.6-1.80.6-2.0-1.8
Bone volume1.52.74.11.31.62.0-1.01.9-1.91.3-2.0-1.6
Breakpoint value in progressive ratio session0.80.91.80.51.00.7-0.61.2-1.00.7-1.3-1.2
Number of licking bursts0.40.71.7-1.3-0.9-0.30.9-0.70.3-1.30.2-0.6
Context. condit. distance diff. score0.10.10.30.20.40.2-0.50.3-0.20.6-0.00.4
Locomotion velocity, session 10.30.40.9-0.9-0.7-0.10.8-0.50.3-0.90.4-0.2
Locomotion distance, session 10.81.02.20.70.81.5-0.51.0-1.20.7-1.2-0.8
Locomotion velocity, session 20.30.41.1-0.5-0.4-0.50.5-0.60.5-0.10.81.1
Locomotion distance, session 20.00.10.20.0-0.20.00.4-0.20.1-0.30.10.5
Locomotion velocity, session 30.60.71.61.00.60.8-1.30.8-0.90.1-1.1-0.6
Locomotion distance, session 30.30.30.70.60.20.8-0.50.4-0.7-0.3-0.8-0.6
Stereotopy head waving bouts, day 32.22.63.21.61.81.4-1.71.8-1.71.6-1.8-0.9
Stereotopy head waving duration, day 30.30.40.70.40.80.3-0.70.8-0.60.9-0.70.1
Locomotion velocity, session 70.50.61.30.50.50.8-0.20.7-0.9-0.1-1.1-1.1
Locomotion distance, session 70.30.41.3-0.7-0.6-0.10.9-0.20.1-1.1-0.3-0.5
Stereotopy head waving bouts, day 70.10.10.70.1-0.0-0.0-0.5-0.1-0.0-0.00.00.9
Stereotopy head waving duration, day 70.50.61.81.10.80.6-1.40.6-0.70.7-0.6-0.1
Locomotion velocity, session 80.30.40.60.60.70.6-0.80.7-0.60.7-0.5-0.5
Locomotion distance, session 80.20.30.60.50.60.7-0.50.7-0.60.6-0.6-0.4
Degree of sensitization distance1.11.22.2-1.5-1.0-1.11.4-0.91.0-0.90.90.6
Degree of sensitization stereotypy0.40.41.6-0.3-0.6-0.6-0.0-0.70.6-0.50.71.2
Conditioned locomotion3.94.57.12.22.02.0-2.32.1-2.01.8-1.9-2.7
Cocaine response after cond. corrected0.30.40.90.10.50.7-0.10.8-0.70.4-0.9-0.8
Cocaine response after cond. not corrected0.91.11.70.71.01.3-0.81.1-1.20.9-1.2-1.0
Cocaine response before conditioning2.02.44.12.01.71.6-2.01.3-1.51.8-0.8-0.8
Saline control response0.91.22.11.31.21.0-1.51.2-1.01.2-1.0-0.3
Bone: connectivity density2.94.66.72.02.02.4-1.82.3-2.41.4-2.6-2.2
Bone: cortical apparent density0.30.31.10.10.40.7-0.30.6-0.60.2-0.7-1.0
Bone: cortical area0.10.20.50.00.20.70.00.4-0.6-0.2-0.7-0.6
Bone: cortical porosity2.02.23.41.81.61.5-1.81.4-1.41.7-1.1-0.1
Bone: cortical porosity1.82.02.71.61.61.5-1.51.4-1.41.6-1.2-0.4
Bone: cortical thickness0.10.20.5-0.4-0.5-0.10.5-0.50.3-0.70.3-0.2
Bone: cortical thickness0.91.12.70.80.81.2-0.61.0-1.20.4-1.3-1.6
Bone: cortical tissue density0.20.20.7-0.10.30.5-0.10.5-0.50.1-0.6-0.8
Condit. Reinf. active minus inactive responses1.31.42.2-1.5-1.3-1.11.3-1.11.1-1.50.90.5
Condit. Reinf. active-inactive response ratio1.21.21.9-1.3-1.2-1.21.4-1.11.1-1.30.90.3
Condit. Reinf. active responses0.10.10.4-0.3-0.10.20.2-0.0-0.1-0.4-0.2-0.6
Condit. Reinf. inactive responses1.11.32.21.01.21.5-1.11.2-1.31.0-1.1-0.8
Incentive salience index mean0.10.10.4-0.6-0.3-0.20.6-0.10.1-0.5-0.10.1
Condit. Reinf. lever presses0.50.71.10.61.00.9-0.41.0-0.91.0-0.9-0.0
Condit. Reinf. active minus inactive responses3.44.48.32.51.72.2-2.91.7-2.11.0-1.9-2.3
Condit. Reinf. active-inactive response ratio1.21.34.61.40.91.2-2.10.8-1.10.7-0.8-0.7
Condit. Reinf. active responses2.73.75.72.31.52.0-2.31.6-2.00.7-2.0-2.4
Condit. Reinf. inactive responses1.11.43.91.10.91.2-0.51.2-1.30.3-1.5-2.0
Condit. Reinf. lever presses2.12.94.52.11.51.8-2.01.4-1.61.2-1.4-2.1
Condit. Reinf. lever reinforcers received2.53.55.62.31.51.9-2.41.5-1.90.7-1.8-2.3
Conditioned reinforcement - actives3.25.58.22.52.61.9-2.42.5-2.02.9-1.9-2.2
Conditioned reinforcement - inactives3.04.56.71.62.52.0-1.82.4-2.22.6-2.0-1.8
Conditioned locomotion1.11.52.81.51.40.8-1.41.3-1.01.7-1.0-0.5
Patch foraging indifference point 0 sec0.91.77.7-1.1-1.0-1.00.9-0.91.0-1.00.62.8
Patch foraging indifference point AUC0.60.93.9-0.10.31.2-0.20.6-1.1-0.4-1.1-2.0
Delay disc. indifference point, 0s delay2.62.94.5-1.8-1.6-1.82.1-1.71.8-1.12.01.1
Delay disc. indifference point, 16s delay0.10.10.60.3-0.10.3-0.3-0.0-0.1-0.4-0.1-0.8
Delay disc. indifference point, 2s delay0.20.20.4-0.5-0.5-0.40.5-0.50.4-0.50.60.1
Delay disc. indifference point, 24s delay1.11.22.11.21.31.2-1.01.1-1.01.4-0.7-0.8
Delay disc. indifference point, 4s delay0.20.20.9-0.4-0.2-0.00.5-0.10.0-0.50.1-0.9
Delay disc. indifference point, 8s delay0.10.10.50.20.10.2-0.10.1-0.10.1-0.1-0.7
Indifference point function ln k0.40.82.41.21.00.4-0.90.8-0.41.5-0.30.6
Indifference point function log k0.40.82.41.21.00.4-0.90.8-0.41.5-0.30.6
Patch foraging total patch changes 0 sec1.01.88.2-1.2-1.0-1.01.0-1.00.9-1.10.72.9
Patch foraging total patch changes 12 sec1.72.13.2-1.7-1.4-1.31.6-1.41.2-1.51.21.8
Patch foraging total patch changes 18 sec0.60.92.3-1.2-1.0-0.50.9-0.70.5-1.50.21.0
Patch foraging total patch changes 24 sec1.01.62.4-1.3-1.4-1.21.2-1.41.2-1.51.21.2
Patch foraging total patch changes 6 sec0.91.33.6-1.4-1.3-0.71.0-1.20.7-1.90.51.1
Patch foraging time to switch 0 sec0.10.20.4-0.4-0.4-0.50.2-0.40.3-0.60.20.3
Patch foraging water rate 0 sec0.30.61.31.10.80.5-0.80.5-0.41.1-0.20.9
Patch foraging water rate 12 sec0.30.71.7-0.1-0.7-1.00.5-0.91.2-0.21.30.6
Patch foraging water rate 18 sec0.30.51.21.00.3-0.3-0.4-0.20.41.10.90.9
Patch foraging water rate 24 sec0.91.32.4-0.6-0.9-1.60.8-1.11.4-0.51.51.3
Patch foraging water rate 6 sec0.40.61.80.1-0.4-0.80.4-0.71.00.41.41.0
Seeking ratio, delayed vs. immediate footshock0.00.00.10.0-0.2-0.1-0.0-0.30.1-0.30.20.3
Distance traveled before self-admin0.10.20.70.60.10.3-0.2-0.00.00.50.4-0.8
Distance traveled after self-admin1.62.03.0-1.4-1.5-1.31.7-1.51.6-1.11.70.6
Extensor digitorum longus weight3.814.917.24.13.74.1-4.13.9-4.12.8-4.1-3.8
Bone: elastic displacement1.21.42.01.01.31.0-0.91.4-1.01.4-1.3-1.1
Bone: elastic work0.91.22.40.81.01.2-0.71.2-1.00.8-1.4-1.6
Bone: endosteal estimation0.30.71.50.40.81.0-0.11.0-1.10.5-1.2-1.0
Bone: endosteal perimeter0.10.20.50.10.30.60.10.5-0.60.1-0.7-0.7
Epididymis fat weight16.456.263.9-7.7-7.8-8.07.6-7.77.7-7.37.26.2
Delta time in closed arm before/after self-admin0.20.20.9-0.6-0.2-0.20.2-0.10.0-0.6-0.30.9
Delta time in open arm before/after self-admin0.10.10.30.10.20.2-0.20.3-0.30.1-0.4-0.6
Diff in mean of infusions in LGA sessions0.10.10.3-0.3-0.10.00.20.2-0.1-0.2-0.50.4
Delay discount exponential model param0.30.31.8-0.3-0.4-0.60.3-0.40.5-0.10.41.3
Extinction: sum of active levers before priming0.30.30.6-0.10.80.3-0.20.7-0.60.6-0.50.6
Active lever presses in extinction session 61.11.11.81.01.30.8-1.01.2-1.01.3-1.0-0.6
Bone: final force0.00.10.1-0.30.00.30.30.1-0.3-0.2-0.3-0.3
Bone: final moment0.10.10.3-0.30.10.40.30.2-0.3-0.2-0.4-0.5
Food consumed during 24 hour testing period0.10.10.70.1-0.10.4-0.20.1-0.3-0.3-0.3-0.8
Glucose0.40.71.4-0.9-1.0-0.70.8-0.80.7-1.20.50.8
Heart weight2.74.26.0-2.1-1.8-2.12.3-2.12.1-1.12.52.1
Delay discount hyperbolic model param0.20.21.20.0-0.2-0.40.0-0.20.30.10.31.1
Intermittent access intake day 1-15 change0.30.61.61.10.80.7-0.80.7-0.61.3-0.4-0.4
Intermittent access intake escalation0.10.20.80.70.40.4-0.40.3-0.20.9-0.1-0.3
Intermittent access intake escalation 20.10.10.30.40.00.3-0.20.1-0.10.20.0-0.6
Intermitt. access day 1 inactive lever presses0.41.52.21.21.31.2-1.51.2-1.31.2-1.2-0.8
Intermitt. access day 15 inactive lever presses2.24.56.81.61.92.6-2.02.1-2.51.3-2.5-2.3
Intermitt. access escalation Index1.82.65.8-2.0-1.9-1.21.6-1.61.1-2.40.81.2
Intermittent access day 1 total infusions3.35.36.12.42.42.3-2.52.4-2.32.1-2.3-2.1
Intermittent access day 15 total infusions2.13.14.52.01.91.7-1.81.8-1.72.1-1.5-1.3
Intermittent access terminal intake (last 3 days)3.34.35.52.32.22.1-2.22.1-2.02.3-1.8-1.8
Intermittent access total infusions3.74.46.42.32.41.8-2.32.2-1.92.5-1.8-1.4
Intermittent access day 1 locomotion1.92.43.41.51.91.5-1.61.7-1.61.7-1.5-0.3
Intermittent access day 15 total locomotion0.20.40.70.50.60.5-0.70.7-0.60.6-0.7-0.8
Intermittent access total locomotion0.81.02.30.81.30.6-1.01.1-0.81.5-0.9-0.2
Intermittent access standard deviation0.92.02.71.31.61.5-1.41.6-1.41.6-1.4-0.3
Left kidney weight0.10.42.30.00.4-0.10.10.10.00.90.21.5
Right kidney weight0.41.94.9-1.3-0.9-1.41.5-1.21.4-0.11.62.2
Cocaine induced anxiety0.10.10.3-0.10.30.3-0.10.4-0.50.2-0.5-0.0
Post-drug Anxiety1.71.82.5-1.6-1.4-1.21.6-1.41.3-1.31.31.1
Baseline Anxiety3.23.74.6-1.8-2.1-1.92.0-2.12.1-2.01.91.0
Tail length0.20.71.6-0.6-0.6-0.91.0-0.91.0-0.01.30.8
Length with tail1.14.99.1-1.8-1.7-2.42.3-2.02.5-0.72.73.0
Length without tail0.62.08.7-1.1-0.7-1.31.3-0.91.3-0.21.22.9
Times rat made contact with spout1.31.52.11.21.11.3-1.31.2-1.30.7-1.5-1.3
Lifetime Intake3.94.87.32.32.51.8-2.32.4-2.02.7-2.0-1.3
Liver weight, left3.35.46.7-2.4-2.2-2.62.6-2.42.5-1.82.61.8
Liver weight, right7.913.918.7-3.6-3.3-4.13.9-3.84.0-2.34.33.9
Locomotor activity0.81.22.9-1.7-0.8-1.01.3-0.80.8-1.00.71.4
Locomotor testing distance0.10.20.7-0.8-0.1-0.10.20.1-0.2-0.7-0.60.2
Locomotor testing rearing0.50.92.40.51.10.7-1.01.2-1.10.6-1.50.2
Locomotion in novel chamber0.10.10.30.0-0.2-0.4-0.0-0.20.2-0.30.2-0.6
Locomotion in novel chamber post-restriction2.94.76.1-2.2-2.1-2.52.0-2.12.2-2.11.92.4
Fecal boli incidents, locomotor time 10.71.02.91.31.20.8-1.01.0-0.81.7-0.5-0.2
Change in fecal boli incidents, locomotor task4.24.25.4-2.3-2.1-2.12.3-2.02.1-2.01.91.2
Time >=10cm from walls, locomotor time 10.10.10.50.20.2-0.10.0-0.00.20.70.4-0.5
Bouts of movement, locomotor time 10.91.01.61.00.51.2-1.30.7-1.1-0.2-1.1-1.2
Total resting periods, locomotor time 11.11.32.31.10.61.4-1.30.8-1.2-0.2-1.3-1.5
Rest time, locomotor task time 10.10.10.30.0-0.4-0.10.1-0.30.2-0.50.1-0.2
Distance moved, locomotor task time 10.60.91.5-1.1-0.7-1.11.2-0.81.0-0.21.10.9
Vertical activity count, locomotor time 10.20.40.8-0.7-0.5-0.70.9-0.60.7-0.30.80.3
Time >=10cm from walls, locomotor time 20.60.81.80.91.10.8-0.70.9-0.81.3-0.4-1.1
Bouts of movement, locomotor time 20.10.20.5-0.3-0.7-0.20.1-0.60.4-0.70.50.5
Total resting periods, locomotor time 20.10.10.60.0-0.50.1-0.2-0.40.1-0.70.10.3
Rest time, locomotor task time 20.60.81.40.90.51.2-1.00.8-1.00.1-1.2-0.7
Distance moved, locomotor task time 20.50.61.2-0.9-0.5-1.01.1-0.70.9-0.11.10.1
Vertical activity count, locomotor time 20.20.20.6-0.4-0.1-0.70.6-0.40.50.30.80.1
Light reinforcement 11.33.25.51.51.62.3-1.91.9-2.20.9-2.40.0
Light reinforcement 21.82.84.51.71.42.1-1.71.7-1.91.1-1.8-1.5
Bone: marrow area0.30.71.50.40.81.0-0.11.0-1.10.5-1.2-1.0
Bone: maximum diameter0.40.71.80.30.61.1-0.10.9-1.10.0-1.3-0.9
Bone: maximum force0.10.10.3-0.00.20.5-0.00.3-0.40.1-0.4-0.2
Bone: maximum moment0.10.20.40.10.30.6-0.00.4-0.50.1-0.6-0.5
Mean time between licks in bursts1.33.24.1-1.7-1.8-2.02.0-1.92.0-1.32.01.3
Mean num. licks in bursts0.71.12.51.61.10.7-1.21.0-0.71.4-0.7-0.1
Cd content in liver0.10.10.9-0.3-0.0-0.10.20.1-0.0-0.0-0.21.0
Co content in liver5.46.37.62.52.62.8-2.32.6-2.72.7-2.5-1.9
Cu content in liver0.20.20.50.30.60.5-0.30.4-0.40.7-0.2-0.3
Fe content in liver1.21.52.60.71.61.3-0.91.4-1.31.6-1.2-0.3
K content in liver0.10.10.4-0.6-0.10.50.50.0-0.3-0.1-0.3-0.0
Mg content in liver0.40.42.0-0.80.10.50.60.2-0.40.3-0.41.4
Mn content in liver0.40.41.8-0.8-0.4-0.20.6-0.1-0.0-0.7-0.51.3
Na content in liver1.01.12.51.01.21.2-0.81.0-1.01.6-0.6-0.9
Rb content in liver0.20.31.2-0.9-0.2-0.20.6-0.10.1-0.3-0.01.1
Se content in liver0.40.42.5-0.8-0.3-0.40.4-0.30.2-0.20.21.6
Sr content in liver0.10.10.30.2-0.1-0.10.1-0.20.30.30.4-0.5
Zn content in liver1.21.33.3-1.3-0.9-0.81.5-1.01.0-0.51.01.8
Bone: minimum diameter0.30.51.3-1.0-0.7-0.51.1-0.60.4-0.80.20.6
Time in familiar zone, hab. session 11.01.01.7-1.3-0.9-1.01.3-0.80.8-0.90.81.1
Time in novel zone, hab. session 10.30.30.6-0.1-0.5-0.7-0.1-0.50.6-0.40.40.8
Total zone transitions, hab. session 10.10.20.20.50.40.4-0.50.5-0.40.3-0.40.1
Total locomotion distance, hab. session 10.20.30.90.30.80.5-0.20.7-0.50.9-0.5-0.4
Locomotion velocity, hab. session 10.91.31.70.81.31.2-0.81.3-1.21.3-1.1-1.2
Time in familiar zone, hab. session 20.10.10.4-0.4-0.3-0.1-0.0-0.20.1-0.7-0.10.3
Time in novel zone, hab. session 20.30.30.5-0.4-0.3-0.70.7-0.50.60.00.70.4
Total zone transitions, hab. session 20.00.10.3-0.1-0.20.20.2-0.0-0.1-0.5-0.20.2
Total locomotion distance, hab. session 20.10.10.3-0.0-0.30.4-0.0-0.0-0.2-0.6-0.3-0.3
Locomotion velocity, hab. session 20.10.10.30.2-0.10.6-0.20.1-0.4-0.4-0.5-0.5
Novel to familiar place preference ratio1.01.12.3-0.8-0.9-1.10.9-1.01.1-0.61.11.5
Novelty place preference1.51.62.9-1.0-1.2-1.41.1-1.31.4-0.81.31.7
Time in novel zone, NPP test1.61.83.6-1.0-1.2-1.51.1-1.31.4-0.81.41.9
Total zone transitions, NPP test1.11.62.51.31.31.6-1.21.3-1.41.1-1.3-0.7
Total locomotion distance, NPP test1.52.12.91.41.51.7-1.61.5-1.61.2-1.5-0.8
Locomotion velocity, NPP test2.43.34.61.71.82.2-1.92.0-2.01.5-2.0-1.3
Intraocular pressure6.18.811.1-3.3-2.9-3.33.1-2.83.0-2.52.82.8
Delta distance traveled before/after self-admin2.22.43.8-1.7-1.7-1.51.6-1.61.4-1.91.30.6
Delta ambulatory time before/after self-admin0.60.71.4-1.1-0.8-0.61.0-0.80.6-1.20.50.6
Parametrial fat weight14.133.144.3-5.7-6.7-5.45.8-6.45.8-6.55.63.2
Pavlov. Cond. lever latency0.81.11.7-0.7-1.0-1.30.8-1.21.3-0.71.30.6
Pavlov. Cond. magazine entry latency0.10.10.4-0.30.00.1-0.00.1-0.2-0.2-0.20.6
Pavlov. Cond. change in total contacts0.00.00.1-0.10.20.10.10.2-0.20.3-0.10.4
Pavlov. Cond. index score0.20.30.6-0.00.50.6-0.20.6-0.70.2-0.70.3
Pavlov. Cond. latency score0.20.20.6-0.00.40.6-0.20.6-0.70.1-0.80.3
Pavlov. Cond. lever contacts0.60.71.10.50.91.0-0.51.0-1.00.7-1.0-0.2
Pavlov. Cond. magazine entry number0.10.10.3-0.0-0.3-0.50.3-0.40.6-0.00.6-0.1
Pavlov. Cond. intertrial magazine entries1.61.92.61.31.51.4-1.21.4-1.31.6-1.2-1.4
Pavlov. Cond. lever-magazine prob. diff.0.60.71.20.40.91.0-0.61.0-1.10.6-1.1-0.2
Pavlov. Cond. response bias0.70.91.40.71.01.1-0.81.1-1.20.9-1.1-0.4
Pavlov. Cond. lever latency1.62.15.5-1.7-1.1-1.51.5-1.11.4-0.81.12.3
Pavlov. Cond. magazine entry latency0.50.64.10.70.10.6-0.40.2-0.5-0.3-0.4-2.0
Pavlov. Cond. change in total contacts0.71.24.81.10.50.9-1.20.7-0.9-0.0-0.9-2.2
Pavlov. Cond. index score1.31.86.21.50.81.3-1.30.9-1.20.4-1.0-2.5
Pavlov. Cond. latency score1.41.96.31.60.91.4-1.30.9-1.20.5-1.1-2.5
Pavlov. Cond. lever contacts1.01.43.41.40.91.2-1.30.8-1.10.6-0.9-1.8
Pavlov. Cond. magazine entry number0.40.53.7-0.40.1-0.50.2-0.00.30.50.31.9
Pavlov. Cond. intertrial magazine entries3.35.07.5-2.2-2.1-2.42.1-2.22.3-1.72.22.7
Pavlov. Cond. lever-magazine prob. diff.0.91.25.51.10.51.1-1.00.6-0.90.1-0.8-2.4
Pavlov. Cond. response bias1.72.37.21.61.11.6-1.51.1-1.40.7-1.1-2.7
Time in closed arm before self-admin0.50.61.2-0.8-0.7-1.10.8-0.60.9-0.50.60.9
Time in closed arm after self-admin0.91.02.1-1.1-1.0-1.40.9-0.71.1-1.20.60.6
Time in open arm before self-admin0.00.00.20.2-0.00.3-0.2-0.0-0.1-0.3-0.10.4
Time in open arm after self-admin0.70.81.30.70.81.1-0.80.8-1.10.6-0.9-0.8
Bone: periosteal estimation0.40.91.80.50.91.2-0.21.1-1.20.5-1.3-1.0
Bone: periosteal perimeter0.10.20.60.20.30.8-0.00.4-0.70.1-0.7-0.6
Bone: post-yield work1.31.92.81.51.61.3-1.41.5-1.41.7-1.30.0
Progressive ratio test 1 active lever presses2.22.74.41.62.01.3-1.71.8-1.52.1-1.5-1.0
Progressive ratio test 1 breakpoint2.22.74.61.62.01.3-1.71.8-1.52.1-1.5-0.9
Progressive ratio test 1 inactive lever presses3.95.77.72.22.72.2-2.42.5-2.32.8-2.2-2.1
Progressive ratio test 2 active lever presses1.41.64.21.51.60.8-1.31.3-0.92.0-0.7-0.7
Progressive ratio test 2 breakpoint1.21.43.81.41.50.7-1.21.2-0.82.0-0.6-0.6
Progressive ratio test 2 inactive lever presses2.03.34.91.82.11.6-1.81.9-1.72.2-1.5-1.5
Incentive Sensitization - Responses0.50.72.31.01.10.7-0.70.8-0.71.5-0.40.1
Incentive Sensitization - Breakpoint0.40.51.60.90.90.6-0.50.6-0.51.3-0.20.2
Sum of active levers in priming session hrs 5-60.20.20.5-0.6-0.10.30.4-0.0-0.3-0.7-0.3-0.5
Progressive ratio0.00.00.1-0.3-0.1-0.40.2-0.10.1-0.20.00.2
Food seeking constrained by brief footshock6.37.714.22.93.52.4-2.73.0-2.63.8-2.30.1
Seeking ratio, punishment vs. effort0.71.02.01.11.21.1-1.01.1-0.91.4-0.7-0.2
Retroperitoneal fat weight26.2111.9139.2-11.1-11.6-10.810.7-11.110.6-11.89.57.4
Reaction time number correct0.30.61.11.00.61.0-0.90.7-0.80.4-0.8-0.7
Reaction time mean minus median0.10.31.90.40.1-0.0-0.40.2-0.0-0.0-0.2-1.4
Reaction time mean minus median AUC0.00.10.3-0.1-0.3-0.30.1-0.10.3-0.30.1-0.5
Reaction time num false alarms0.71.02.7-1.1-1.1-0.60.9-0.80.5-1.60.21.4
Reaction time num false alarms AUC0.71.12.8-1.2-1.1-0.51.0-0.90.5-1.70.21.5
Reaction time trials correct on left0.30.61.11.00.61.0-0.90.7-0.80.4-0.8-0.7
Reaction time trials on left0.40.71.01.00.71.0-0.90.7-0.90.4-0.8-0.8
Reaction time mean0.60.91.9-0.9-0.8-1.21.1-0.91.2-0.21.4-0.1
Reaction time mean AUC0.50.71.6-0.8-0.7-1.11.0-0.81.1-0.11.3-0.0
Median of all reaction times0.81.22.4-1.1-0.8-1.21.4-1.01.3-0.11.50.4
Reaction time omissions0.00.10.2-0.4-0.1-0.10.20.1-0.1-0.4-0.2-0.3
Reaction time false alarm rate1.21.73.2-1.6-1.4-1.01.4-1.10.9-1.80.51.6
Reaction time premature initiation rate0.20.20.8-0.2-0.4-0.40.1-0.50.4-0.40.50.9
Reaction time premature initiations0.00.10.20.3-0.00.1-0.3-0.1-0.0-0.10.00.4
Std. dev. reaction times0.20.41.4-0.2-0.5-0.70.4-0.40.6-0.40.6-1.2
Reaction time trials completed0.40.71.01.00.71.0-0.90.7-0.90.4-0.8-0.8
Reaction time trials AUC0.40.81.41.20.71.1-1.10.8-1.00.5-0.9-0.8
Run reversals in cocaine runway, females0.20.20.60.70.30.1-0.30.20.00.80.2-0.4
Run reversals in cocaine runway, males0.40.40.80.90.70.4-0.70.6-0.40.9-0.3-0.4
Latency to leave start box in cocaine runway0.91.02.31.00.91.1-0.80.9-0.90.9-0.9-1.5
Latency to leave start box in cocaine runway, F0.20.20.60.30.40.6-0.20.4-0.50.3-0.5-0.8
Latency to leave start box in cocaine runway, M0.70.61.41.20.60.6-0.90.6-0.50.9-0.4-1.2
Std. dev. time between licks in bursts0.60.81.6-1.2-0.9-0.71.1-0.90.6-1.10.60.3
Total sessions with >9 infusions1.82.24.11.51.81.0-1.61.7-1.32.0-1.3-0.3
Short access day 1 total inactive lever presses6.07.89.72.13.12.8-2.53.1-3.02.8-2.9-2.7
Short access day 10 total inactive lever presses1.12.73.71.51.61.9-1.81.7-1.91.1-1.9-1.2
Short access day 1 total infusions4.66.07.72.22.82.2-2.52.7-2.52.5-2.6-2.1
Short access day 10 total infusions3.13.96.32.02.41.7-1.92.2-1.82.5-1.7-1.3
Short access total infusions2.02.64.21.52.01.2-1.61.9-1.52.1-1.5-0.9
Short access day 1 locomotion3.74.66.42.32.21.9-2.52.2-2.11.9-2.1-1.9
Short access day 10 total locomotion1.22.23.71.81.61.5-1.91.5-1.51.5-1.30.3
Short access total locomotion0.60.81.70.91.10.5-1.00.9-0.61.3-0.60.3
One hour access (0.3 mA shock)2.52.94.41.91.81.5-1.81.7-1.42.1-1.3-1.6
Compulsive drug intake1.92.33.0-1.7-1.6-1.31.7-1.41.3-1.61.21.6
One hour access (shock baseline)3.45.27.52.62.42.0-2.42.2-1.92.7-1.7-2.4
Social response proportion0.10.10.2-0.2-0.0-0.30.4-0.10.40.40.40.3
Social responses0.20.21.0-0.5-0.4-0.20.4-0.50.3-0.20.41.0
Social time0.20.31.3-0.2-0.1-0.40.3-0.30.40.30.61.1
Soleus weight4.011.714.03.73.43.7-3.33.5-3.62.9-3.5-3.1
Bone: stiffness0.00.00.1-0.2-0.20.2-0.2-0.3-0.1-0.40.20.3
Tibialis anterior weight2.79.111.33.32.63.4-3.12.9-3.31.7-3.3-3.2
Time to tail flick, vehicle, before self-admin0.30.31.0-0.2-0.5-1.00.3-0.50.8-0.00.60.2
Time to tail flick, vehicle, after self-admin2.73.65.0-1.8-2.2-2.21.8-1.92.2-2.01.60.8
Time to tail flick, test, before self-admin0.10.10.50.20.40.0-0.30.3-0.30.5-0.3-0.7
Time to tail flick, test, after self-admin0.70.72.01.10.80.4-0.80.8-0.41.4-0.5-0.6
Delta time to tail flick, vehicle, before/after SA0.40.41.5-0.6-0.8-0.40.6-0.50.4-1.20.10.1
Delta time to tail flick, test, before/after SA1.92.03.01.61.51.5-1.31.5-1.31.7-1.2-0.8
Tibia length2.46.610.6-2.6-2.1-2.72.8-2.42.6-1.42.83.3
Ambulatory time before self-admin0.10.20.40.60.30.4-0.30.1-0.10.60.3-0.6
Ambulatory time after self-admin1.11.32.4-1.1-1.0-0.91.3-1.21.2-0.71.60.8
Bone: tissue strength0.60.61.0-0.5-0.9-0.80.7-1.01.0-0.81.0-0.2
Total heroin consumption2.42.83.51.41.71.7-1.61.9-1.81.4-1.8-1.5
Bone: trabecular number2.74.45.61.92.12.4-1.52.3-2.31.9-2.3-2.2
Bone: trabecular spacing2.53.36.9-1.5-1.4-1.91.3-1.91.9-0.92.22.6
Bone: trabecular thickness0.50.61.30.30.70.9-0.01.0-0.90.7-1.1-0.6
Bone: trabecular tissue density0.30.51.00.50.70.8-0.80.6-0.70.6-0.5-1.0
Water consumed over 24 hours0.30.31.8-0.1-0.10.6-0.10.1-0.4-0.7-0.5-1.3
Number of responses in last shaping day0.70.81.30.61.10.5-0.61.0-0.71.0-0.7-1.1